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https://www.readbyqxmd.com/read/28719898/role-of-mir-155-signal-pathway-in-regulating-podocyte-injury-induced-by-tgf-%C3%AE-1
#1
Xu Lin, Xintng Zhen, Haiting Huang, Haohao Wu, Yanwu You, Pengwei Guo, Xiangjun Gu, Fafen Yang
BACKGROUND/AIMS: Transforming growth factor beta 1 (TGF-β1) plays a critical role in the pathogenesis of glomerulosclerosis. The purpose of this study was to examine the effects of inhibition of miR-155 on podocyte injury induced by TGF-β1 and to determine further molecular mediators involved in the effects of miR-155. METHODS: Conditionally immortalized podocytes were cultured in vitro and they were divided into four groups: control; TGF-β1 treatment; TGF-β1 with miR-155 knockdown [using antisense oligonucleotides against miR-155 (ASO-miR-155)] and TGF-β1 with negative control antisense oligonucleotides (ASO-NC)...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28719840/environmental-and-human-health-challenges-of-industrial-livestock-and-poultry-farming-in-china-and-their-mitigation
#2
REVIEW
Yuanan Hu, Hefa Cheng, Shu Tao
Driven by the growing demand for food products of animal origin, industrial livestock and poultry production has become increasingly popular and is on the track of becoming an important source of environmental pollution in China. Although concentrated animal feeding operations (CAFOs) have higher production efficiency and profitability with less resource consumption compared to the traditional family-based and "free range" farming, they bring significant environmental pollution concerns and pose public health risks...
July 15, 2017: Environment International
https://www.readbyqxmd.com/read/28719641/inversion-of-the-imprinting-control-region-of-the-peg3-domain
#3
Joomyeong Kim, Hongzhi He, Hana Kim
The imprinting of the mouse Peg3 domain is controlled through a 4-kb genomic region encompassing the bidirectional promoter and 1st exons of Peg3 and Usp29. In the current study, this ICR was inverted to test its orientation dependency for the transcriptional and imprinting control of the Peg3 domain. The inversion resulted in the exchange of promoters and 1st exons between Peg3 and Usp29. Paternal transmission of this inversion caused 10-fold down-regulation of Peg3 and 2-fold up-regulation of Usp29 in neonatal heads, consistent with its original promoter strength in each direction...
2017: PloS One
https://www.readbyqxmd.com/read/28719613/visual-detection-of-brucella-in-bovine-biological-samples-using-dna-activated-gold-nanoparticles
#4
Dheeraj Pal, Nongthombam Boby, Satish Kumar, Gurpreet Kaur, Syed Atif Ali, Julien Reboud, Sameer Shrivastava, Praveen K Gupta, Jonathan M Cooper, Pallab Chaudhuri
Brucellosis is a bacterial disease, which, although affecting cattle primarily, has been associated with human infections, making its detection an important challenge. The existing gold standard diagnosis relies on the culture of bacteria which is a lengthy and costly process, taking up to 45 days. New technologies based on molecular diagnosis have been proposed, either through dip-stick, immunological assays, which have limited specificity, or using nucleic acid tests, which enable to identify the pathogen, but are impractical for use in the field, where most of the reservoir cases are located...
2017: PloS One
https://www.readbyqxmd.com/read/28719576/laser-induced-plasmonic-colours-on-metals
#5
Jean-Michel Guay, Antonino Calà Lesina, Guillaume Côté, Martin Charron, Daniel Poitras, Lora Ramunno, Pierre Berini, Arnaud Weck
Plasmonic resonances in metallic nanoparticles have been used since antiquity to colour glasses. The use of metal nanostructures for surface colourization has attracted considerable interest following recent developments in plasmonics. However, current top-down colourization methods are not ideally suited to large-scale industrial applications. Here we use a bottom-up approach where picosecond laser pulses can produce a full palette of non-iridescent colours on silver, gold, copper and aluminium. We demonstrate the process on silver coins weighing up to 5 kg and bearing large topographic variations (∼1...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719348/trim59-is-a-key-regulator-of-growth-and-migration-inrenal-cell-carcinoma
#6
S-H Hu, M-J Zhao, W-X Wang, C-W Xu, G-D Wang
Renal cell carcinoma (RCC) is the most common renal neoplasms and metastatic is common. Previous data have shown that the tripartite motif (TRIM) family proteinswere implicated in human tumoriogenesis. In this study, we aimed to investigate the role of TRIM59 in the cell growth and migration in RCC. The expression of TRIM59 in human RCC tissues was initially examined by qRT-PCR. Alentivirus-based shRNA against TRIM59 (Lv-shTRIM59) was constructed. The effects of TRIM59 knockdown on cell proliferation were examined by in vitro MTT assay, colony formation assay and in vivo a mouse xenograft model of RCC...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28719347/regulatory-effects-of-the-novel-synthesized-indole-3-carbaldehyde-on-expression-of-cell-cycle-genes-a-study-on-cyclin-d-and-p21-expression-by-acute-promylocytic-leukemia-cell-line-nb4
#7
M N Karimabad, M Mahmoodi, A Jafarzadeh, A Darekordi, M R Hajizadeh, H Khorramdelazad, A R Sayadi, S Khanamani Falahati-Pour, G Hassanshahi
A large variety of heterocycles are known to date and among these, indole and pyran rings are of particular interest. The present investigation was aimed to investigate the effects of novel Indole-3-carbaldehyde derivative (NI-3-CD) analogue on growth inhibition of cells and its regulatory effects on expression of cell cycle genes in acute promylocytic leukemia (APL) cell line. NB4 cells were cultured in presence of RPMI1640 medium contained various concentrations of NI-3-CD and basal compound of indole (I3C) (15...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28719216/exploring-ultimate-water-capillary-evaporation-in-nanoscale-conduits
#8
Yinxiao Li, Mohammad Amin Alibakhshi, Yihong Zhao, Chuanhua Duan
Capillary evaporation in nanoscale conduits is an efficient heat/mass transfer strategy that has been widely utilized by both nature and mankind. Despite its broad impact, the ultimate transport limits of capillary evaporation in nanoscale conduits, governed by the evaporation/condensation kinetics at the liquid-vapor interface, have remained poorly understood. Here we report experimental study of the kinetic limits of water capillary evaporation in 2-D nanochannels using a novel hybrid channel design. Our results show that the kinetic-limited evaporation fluxes break down the limits predicated by the classical Hertz-Knudsen equation by an order of magnitude, reaching values up to 37...
July 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28719195/fluorinated-boronic-acid-appended-pyridinium-salts-and-19f-nmr-spectroscopy-for-diol-sensing
#9
Jörg Axthelm, Sven H C Askes, Martin Elstner, Upendar Reddy Gandra, Helmar Görls, Peter Bellstedt, Alexander Schiller
The identification and discrimination of diols is of fundamental importance in medical diagnostics, such as measuring the contents of glucose in the urine of diabetes patients. Diol sensors are often based on fluorophore-appended boronic acids, but these severely lack discrimination power and their response is one-dimensional. As an alternative strategy, we present the use of fluorinated boronic acid-appended pyridinium salts in combination with 19F NMR spectroscopy. A pool of 59 (bio)analytes was screened, containing monosaccharides, phosphorylated and N-acetylated sugars, polyols, carboxylic acids, nucleotides and amines...
July 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28719183/streptomyces-virginiae-ppdc-is-a-new-type-of-phenylpyruvate-decarboxylase-composed-of-two-subunits
#10
Xiaoshu Xu, Chao Wang, Jun Chen, Sheng Yang
Streptomyces virginiae phenylpyruvate decarboxylase (PPDC) has not been identified before. Two putative branched-chain α-keto acid dehydrogenase subunit genes bkdC and bkdD from S. virginiae are similar to halves of other PPDC coding sequences. We cloned and characterized them biochemically in this work. The two proteins formed a stable complex attested by pull-down assay, consistent with the finding that their soluble expression was obtained only when they were coexpressed in Escherichia coli. The subunits were redesignated as SvPPDCα and SvPPDCβ, because the SvPPDCα/β complex catalyzed the conversion of phenylpyruvate to phenylacetaldehyde, reflecting the nature of the enzyme...
July 18, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28719035/melatonin-inhibits-nucleus-pulposus-np-cell-proliferation-and-extracellular-matrix-ecm-remodeling-via-the-melatonin-membrane-receptors-mediated-pi3k-akt-pathway
#11
Zheng Li, Xingye Li, Chong Chen, Matthew T V Chan, William Ka Kei Wu, Jianxiong Shen
Pinealectomy in vertebrates accelerated intervertebral disc degeneration (IDD). However, the potential mechanisms, particularly, melatonin's role is still to be clarified. In this study, for first time, melatonin membrane receptors of MT1 and MT2 were found to be present in the human intervertebral disc tissues and nucleus pulposus (NP) cells, respectively. Melatonin treatment significantly inhibited NP cell proliferation in dose- dependent manner. Accordingly, melatonin down-regulated gene expression of cyclin D1, PCNA, matrix metallopeptidases-3 and -9 and upregulated gene expression of collagen type II alpha 1 chain and aggrecan in NP cells...
July 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28718979/in-situ-two-step-photoreduced-sers-materials-for-on-chip-single-molecule-spectroscopy-with-high-reproducibility
#12
Wenjie Yan, Longkun Yang, Jianing Chen, Yaqi Wu, Peijie Wang, Zhipeng Li
A method is developed to synthesize surface-enhanced Raman scattering (SERS) materials capable of single-molecule detection, integrated with a microfluidic system. Using a focused laser, silver nanoparticle aggregates as SERS monitors are fabricated in a microfluidic channel through photochemical reduction. After washing out the monitor, the aggregates are irradiated again by the same laser. This key step leads to full reduction of the residual reactants, which generates numerous small silver nanoparticles on the former nanoaggregates...
July 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28718918/a-rapid-confirmatory-test-for-body-fluid-identification
#13
Stephanie T Young, Joshua R Moore, Clifton P Bishop
We have developed a technique that allows investigators to confirm the presence of blood, semen, and/or saliva in a crime scene sample. It is a confirmatory test where multiple samples can be processed in less than an hour, and it is potentially portable, permitting samples to be processed at the crime scene. Samples at a scene giving a positive result can be further processed while those failing to do so may be ignored. There is a large and growing backlog of DNA evidence in the USA, slowing down the criminal justice system...
July 18, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28718911/clear-cell-renal-cell-carcinoma-validation-of-who-isup-grading
#14
Julien Dagher, Brett Delahunt, Nathalie Rioux-Leclercq, Lars Egevad, John R Srigley, Geoffrey Coughlin, Nigel Dunglinson, Troy Gianduzzo, Boon Kua, Greg Malone, Ben Martin, John Preston, Morgan Pokorny, Simon Wood, John Yaxley, Hemamali Samaratunga
AIM: In 2012, the International Society of Urological Pathology (ISUP) introduced a novel grading system for clear cell and papillary renal cell carcinoma (RCC) based upon increasing nucleolar prominence in grades 1 to 3, with the presence of extreme nuclear pleomorphism and/or tumour giant cells and/or sarcomatoid and/or rhabdoid differentiation as criteria for grade 4. This system is now incorporated in the latest World Health Organization renal tumour classification, being designated WHO/ISUP grading...
July 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28718821/tick-haller-s-organ-a-new-paradigm-for-arthropod-olfaction-how-ticks-differ-from-insects
#15
Ann L Carr, Robert D Mitchell Iii, Anirudh Dhammi, Brooke W Bissinger, Daniel E Sonenshine, R Michael Roe
Ticks are the vector of many human and animal diseases; and host detection is critical to this process. Ticks have a unique sensory structure located exclusively on the 1st pairs of legs; the fore-tarsal Haller's organ, not found in any other animals, presumed to function like the insect antennae in chemosensation but morphologically very different. The mechanism of tick chemoreception is unknown. Utilizing next-generation sequencing and comparative transcriptomics between the 1st and 4th legs (the latter without the Haller's organ), we characterized 1st leg specific and putative Haller's organ specific transcripts from adult American dog ticks, Dermacentor variabilis...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718747/the-role-of-temporal-disparity-on-audiovisual-integration-in-low-vision-individuals
#16
Stefano Targher, Rocco Micciolo, Valeria Occelli, Massimiliano Zampini
Recent findings have shown that sounds improve visual detection in low vision individuals when the audiovisual stimuli pairs of stimuli are presented simultaneously and from the same spatial position. The present study purports to investigate the temporal aspects of the audiovisual enhancement effect previously reported. Low vision participants were asked to detect the presence of a visual stimulus (yes/no task) presented either alone or together with an auditory stimulus at different stimulus onset asynchronies (SOAs)...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28718726/effects-of-the-notch1-signaling-pathway-on-human-lung-cancer-a549-cells
#17
Yun Zeng, Bijian Yin, Xinwei Wang, Guohao Xia, Zhengjie Shen, Wenzhe Gu, Mianhua Wu
PURPOSE: To evaluate the effects of the Notch1 signaling pathway on human lung cancer A549 cells. MATERIALS AND METHODS: A549 cells were transfected with recombinant plasmids. Cell proliferation was detected by MTT assay. A tumor-bearing mouse model was established for intratumoral gene injection. Apoptosis-related factors were detected by immunohistochemical assay. Caspase-8, caspase-3, caspase-9, PI3K, pAkt and pSTAT3 expressions were detected by Western blotting...
July 18, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28718698/pegging-down-risk-factors-for-peg-asparaginase-hepatotoxicity-in-patients-with-acute-lymphoblastic-leukemia-%C3%A2
#18
Caitlin R Rausch, Bernard L Marini, Lydia L Benitez, Allison Elias, Patrick W Burke, Dale Bixby, Anthony J Perissinotti
Asparaginase is commonly de-emphasized/omitted in adult acute lymphoblastic leukemia regimens due to poor tolerability, including hepatotoxicity (HTX). Adult patients (n = 100) given induction therapy containing pegylated asparaginase (PEG) from January 2008 to February 2016 were evaluated for HTX. Sixteen patients met criteria for HTX (direct bilirubin >3 g/dL). A multivariable model identified body surface area >2m(2) (OR 7.40; 95% CI: 1.73-31.61, p = .007), albumin <3 mg/dL (OR 4.62; 95% CI: 1...
July 18, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28718684/role-of-gsk-3%C3%AE-in-regulation-of-canonical-wnt-%C3%AE-catenin-signaling-and-pi3-k-akt-oncogenic-pathway-in-colon-cancer
#19
Shelly Jain, Preety Ghanghas, Chandan Rana, S N Sanyal
Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive agents because of their ability in blocking cellular proliferation, and thereby tumor development, and also by promoting apoptosis. GSK-3β, a serine threonine kinase and a negative regulator of the oncogenic Wnt/β-catenin signaling pathway, plays a critical role in the regulation of oncogenesis. Celecoxib and etoricoxib, the two cyclooxygenase-2 (COX-2) selective NSAIDs, and Diclofenac, a preferential COX-2 inhibitory NSAID, had shown uniformly the chemopreventive and anti-neoplastic effects in the early stage of colon cancer by promoting apoptosis as well as an over-expression of GSK-3β while down-regulating the PI3-K/Akt oncogenic pathway...
July 18, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28718472/unveiling-the-irreversible-performance-degradation-of-organo-inorganic-halide-perovskite-films-and-solar-cells-during-heating-and-cooling-processes
#20
Abdullah Al Mamun, Tanzila Tasnim Ava, Hye Ryung Byun, Hyeon Jun Jeong, Mun Seok Jeong, Loi Nguyen, Christine Gausin, Gon Namkoong
While organo-inorganic halide perovskite solar cells show great potential to meet future energy needs, their thermal instability raises serious questions about their commercialization viability. At present, the stability of perovskite solar cells has been studied under various environmental conditions including humidity and temperature. Nonetheless, understanding of the performance of CH3NH3PbI3-xClx perovskite solar cells is limited. This study reports the irreversible performance degradation of CH3NH3PbI3-xClx perovskite solar cells during the heating and cooling processes under AM 1...
July 18, 2017: Physical Chemistry Chemical Physics: PCCP
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