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https://www.readbyqxmd.com/read/28714317/prospective-observational-study-to-determine-the-accuracy-of-first-trimester-serum-biomarkers-and-uterine-artery-dopplers-in-combination-with-maternal-characteristics-and-arteriography-for-the-prediction-of-women-at-risk-of-preeclampsia-and-other-adverse-pregnancy
#1
Rebecca Allen, Joseph Aquilina
OBJECTIVES: To assess the efficacy of biomarkers, arteriography and uterine artery Dopplers for predicting hypertensive disease of pregnancy, small for gestational age and stillbirth. METHODS: This was a prospective first trimester study. Ultrasound was used to assess uterine artery Doppler. Maternal arteriography performed and serum taken for measurement of placental growth factor (PlGF), alpha fetoprotein (AFP), pregnancy associated plasma protein (PAPP-A) and beta human chorionic gonadotrophin (β-hCG) levels...
July 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28712944/a-fe3o4-au-basedpseudo-homogeneous-electrochemical-immunosensor-for-afp-measurement-using-afp-antibody-gnps-hrp-as-detection-probe
#2
Yulin Yuan, Shanshan Li, Yewei Xue, Jintao Liang, Lijie Cui, Qingbo Li, Sufang Zhou, Yong Huang, Guiyin Li, Yongxiang Zhao
In this study, a Fe3O4@Au-based pseudo-homogeneous electrochemical immunosensor was prepared for detection of alpha fetoprotein (AFP), a well-known hepatocellular carcinoma biomarker. The primary antibody (Ab1) was immobilized on Fe3O4@Au NPs as the capture probe. Horseradish peroxidase (HRP) and secondary antibody (Ab2) were conjugated on gold nanoparticles (GNPs) through electrostatic adsorption to form signal-amplifying labels. In the presence of AFP, a sandwich immunocomplex was formed via specific recognition of antigen-antibody in a Fe3O4@Au-basedpseudo-homogeneousreaction system...
July 13, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28712469/subcortical-contributions-to-motor-speech-phylogenetic-developmental-clinical
#3
REVIEW
W Ziegler, H Ackermann
Vocal learning is an exclusively human trait among primates. However, songbirds demonstrate behavioral features resembling human speech learning. Two circuits have a preeminent role in this human behavior; namely, the corticostriatal and the cerebrocerebellar motor loops. While the striatal contribution can be traced back to the avian anterior forebrain pathway (AFP), the sensorimotor adaptation functions of the cerebellum appear to be human specific in acoustic communication. This review contributes to an ongoing discussion on how birdsong translates into human speech...
July 13, 2017: Trends in Neurosciences
https://www.readbyqxmd.com/read/28710882/mid-trimester-preterm-premature-rupture-of-membranes-pprom-etiology-diagnosis-classification-international-recommendations-of-treatment-options-and-outcome
#4
REVIEW
Michael Tchirikov, Natalia Schlabritz-Loutsevitch, James Maher, Jörg Buchmann, Yuri Naberezhnev, Andreas S Winarno, Gregor Seliger
Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal membranes prior to 28 weeks of gestation, complicates approximately 0.4%-0.7% of all pregnancies. This condition is associated with a very high neonatal mortality rate as well as an increased risk of long- and short-term severe neonatal morbidity. The causes of the mid-trimester PPROM are multifactorial. Altered membrane morphology including marked swelling and disruption of the collagen network which is seen with PPROM can be triggered by bacterial products or/and pro-inflammatory cytokines...
July 15, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28710474/persistent-circulation-of-coxsackievirus-a6-of-genotype-d3-in-mainland-of-china-between-2008-and-2015
#5
Yang Song, Yong Zhang, Tianjiao Ji, Xinrui Gu, Qian Yang, Shuangli Zhu, Wen Xu, Yi Xu, Yong Shi, Xueyong Huang, Qi Li, Hong Deng, Xianjun Wang, Dongmei Yan, Wei Yu, Shuang Wang, Deshan Yu, Wenbo Xu
A total of 807 entire VP1 sequences of Coxsackievirus A6 (CV-A6) from mainland of China from 1992 to 2015, including 520 in this study and 287 from the GenBank database, were analysed to provide a basic framework of molecular epidemiological characteristics of CV-A6 in China. Sixty-five VP1 sequences including 46 representative CV-A6 isolates from 807 Chinese strains and 19 international strains from GenBank were used for describing the genotypes and sub-genotypes. The results revealed that CV-A6 strains can be categorised into 4 genotypes designated as A, B, C, and D according to previous data and can be further subdivided into B1-B2, C1-C2, and D1-D3 sub-genotypes...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702132/measuring-levels-of-osteopontin-as-potential-biomarker-for-hepatocellular-carcinoma-in-syrian-patients
#6
Sara Al-Zoubi, Ahmad Wassouf, Almoutassem Billah Zetoune
AIM: This study aims to evaluate plasma osteopontin (OPN) levels as a potential biomarker for hepatocellular carcinoma (HCC). BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein that is associated with tumorigenesis and metastasis. METHODS: We measured plasma levels of OPN in 26 HCC patients, 27 patients with chronic liver diseases (CLD), and 15 healthy control individuals using a standardized ELISA kit. RESULTS: The mean plasma OPN level was significantly higher in the HCC group than the CLD group or the normal control group (p-value =0...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28700355/identification-of-cd14-as-a-potential-biomarker-of-hepatocellular-carcinoma-using-itraq-quantitative-proteomics
#7
Jiao Guo, Rui Jing, Jian-Hong Zhong, Xin Dong, Yun-Xi Li, Yin-Kun Liu, Tian-Ren Huang, Chun-Yan Zhang
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors without effective diagnostic biomarkers. This study intended to dynamically analyze serum proteomics in different pathological stages of liver diseases, and discover potential diagnostic biomarkers for early HCC. Patients with hepatitis B virus (HBV) infection, liver cirrhosis (LC), or HCC together with healthy controls (HC) were enrolled. Proteins differentially expressed between groups were screened using isobaric tagging for relative and absolute quantitation (iTRAQ), and promising HCC biomarker candidates were subjected to bioinformatics analysis, including K-means clustering, gene ontology (GO) and string network analysis...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28696046/survival-impacts-of-lymphocyte-infiltration-into-the-tumor-of-hepatocellular-carcinoma-in-hbv-positive-or-non-b-non-c-patients-who-underwent-curative-resection
#8
Shigeki Nakagawa, Naoki Umezaki, Takanobu Yamao, Takayoshi Kaida, Hirohisa Okabe, Kosuke Mima, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Takatoshi Ishiko, Akira Chikamoto, Hideo Baba
AIM: The prognostic value of lymphocyte infiltration into hepatocellular carcinoma (HCC) is still controversial, and it has not been reported in HBV- and non-B non-C HCC. The aim of this study is to assess the prognostic significance of lymphocyte infiltrate in tumor for the patients of HBV positive and non-B non-C (NBNC) HCC patients. METHODS: This study investigated 145 HBV positive or NBNC patients who underwent hepatectomy for HCC between January 2001 and May 2009...
July 11, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28695992/optimal-radiotherapy-target-volumes-in-intracranial-nongerminomatous-germ-cell-tumors-long-term-institutional-experience-with-chemotherapy-surgery-and-dose-and-field-adapted-radiotherapy
#9
William G Breen, Miran J Blanchard, Amulya Nageswara Rao, David J Daniels, Jan C Buckner, Nadia N Issa Laack
PURPOSE: To evaluate patterns of failure after multimodality treatment of nongerminomatous germ cell tumors (NGGCTs). MATERIALS AND METHODS: We retrospectively reviewed records of 3,440 patients diagnosed with primary intracranial NGGCT between 1988 and 2014. RESULTS: Thirty-four patients received induction chemotherapy followed by radiation with or without surgery. Median follow-up was 11.1 years (0.8-23.3). Outcomes were significantly improved in these 34 patients (5-year overall survival [OS]: 88% versus 50%, P = 0...
July 11, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28693887/novel-1-2-4-triazole-derivatives-as-antitumor-agents-against-hepatocellular-carcinoma
#10
Rasha R Radwan, Nashwa H Zaher, Marwa G El-Gazzar
Fifteen novel 1,2,3-triazole derivatives were prepared in series of synthetic steps starting from 4-amino-5-hydrazino-4H-1,2,4-triazole-3-thiol 1. The structures of the obtained compounds were verified through micoanalytical and spectral data. All the compounds were screened for their anticancer activity against liver human cancer cell lines (HEPG2) using Doxorubicin as standard. The most promising triazolothiadiazine derivative 12 was further tested for its degree of toxicity by estimating the median lethal dose (LD 50) and its antitumor activity through inhibiting the angiogenesis and progression of tumor against diethylnitrosamine (DENA)/CCl4 induced hepatocellular carcinoma (HCC) in rats...
July 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28693284/%C3%AE-human-chorionic-gonadotropin-secreting-intracranial-germ-cell-tumor-associated-with-high-testosterone-in-an-adult-man-a-case-report
#11
Wen-Ping Yang, Hung-Yu Chien, Yi-Chun Lin
A 38-year-old male patient presented with general weakness, polydipsia and a body weight loss of 10 kg in two years. Hypopituitarism with central hypothyroidism and central adrenal insufficiency were noted at Taipei City Hospital (Taipei, Taiwan). However, hypogonadotropic hypergonadism was also observed. The patient was diagnosed with an intracranial β-human chorionic gonadotropin (β-hCG) secreting germ-cell tumor, and brain magnetic resonance imaging revealed that the tumor involved the pineal gland, stalk, posterior pituitary gland, right basal ganglion, hypothalamus, corpus callosum and posterior hippocampus...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693249/hepatocyte-selection-medium-enriched-hepatocellular-carcinoma-cells-are-positive-for-%C3%AE-fetoprotein-and-cd44
#12
Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Tissues surrounding hepatocellular carcinomas (HCCs) lack glucose. Hepatocyte selection medium (HSM) is deficient in glucose and is supplemented with galactose. HCC cells were cultured in HSM to investigate the stem cell markers α-fetoprotein (AFP) and cluster of differentiation 44 (CD44). HCC cells (HLF and PLC/PRF/5 cells) were cultured in HSM. Viable cell numbers were determined on days 0 and 7 following culture in HSM. RNA was isolated and subjected to reverse transcription-quantitative PCR (RT-qPCR) to analyze the mRNA expression levels of AFP and CD44...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693208/efficacy-and-safety-of-sox-chemotherapy-with-or-without-surgery-in-afp-producing-advanced-gastric-cancer
#13
Zhu Li, Xu Hou, Juan Chen, Huidong Sun, Yuetang Mi, Yongling Sui, Yuhong Li, Jiaping Xie, Yingli Qiao, Xiaofeng Lei, Xiaoshuang Che, Jun Liu
The present study investigated the clinical efficacy of S-1 plus oxaliplatin (SOX) regimen, with or without surgery in α-fetoprotein-producing gastric cancer (APGC) with liver metastasis. A total of 24 patients with APGC treated at the Liaocheng People's Hospital between January 2011 and December 2013 were retrospectively reviewed. Clinical efficacy and patient safety were compared between the two groups. The median progression-free survival (PFS) and overall survival (OS) in the SOX group were 6.5 [95% confidence interval (CI), 4...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691252/peptide-backbone-circularization-enhances-antifreeze-protein-thermostability
#14
Corey A Stevens, Joanna Semrau, Dragos Chiriac, Morgan Litschko, Robert L Campbell, David N Langelaan, Steven P Smith, Peter L Davies, John S Allingham
Antifreeze proteins (AFPs) are a class of ice-binding proteins that promote survival of a variety of cold-adapted organisms by decreasing the freezing temperature of bodily fluids. A growing number of biomedical, agricultural and commercial products, such as organs, foods, and industrial fluids, have benefited from the ability of AFPs to control ice crystal growth and prevent ice recrystallization at subzero temperatures. One limitation of AFP use in these latter contexts is their tendency to denature and irreversibly lose activity at the elevated temperatures of certain industrial processing or large-scale AFP production...
July 10, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28691129/preponderance-of-enterovirus-c-in-rd-l20b-cell-culture-negative-stool-samples-from-children-diagnosed-with-acute-flaccid-paralysis-in-nigeria
#15
J A Adeniji, A O Oragwa, U E George, U I Ibok, T O C Faleye, M O Adewumi
Recently, a reverse transcriptase semi-nested polymerase chain reaction (RT-snPCR) assay was recommended by the WHO for direct detection of enteroviruses in clinical specimens. In this study, we use this assay and a modification thereof to screen acute flaccid paralysis (AFP) samples that had previously tested negative for enteroviruses by the RD-L20B algorithm. Thirty paired stool suspensions collected in 2015 as part of the national AFP surveillance program in different states of Nigeria were analyzed in this study...
July 10, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28687477/prognostic-factors-and-predictors-of-sorafenib-benefit-in-patients-with-hepatocellular-carcinoma-analysis-of-two-phase-3-studies
#16
Jordi Bruix, Ann-Lii Cheng, Gerold Meinhardt, Keiko Nakajima, Yoriko De Sanctis, Josep Llovet
BACKGROUND AND AIMS: Sorafenib, an oral multikinase inhibitor, significantly prolonged overall survival (OS) versus placebo in patients with unresectable hepatocellular carcinoma (HCC) in two phase 3 studies, SHARP (Sorafenib HCC Assessment Randomized Protocol) and Asia-Pacific (AP). To assess prognostic factors for HCC and predictive factors of sorafenib benefit, we conducted a pooled exploratory analysis from these placebo-controlled phase 3 studies. METHODS: To identify potential prognostic factors for OS, univariate and multivariate (MV) analyses were performed for baseline variables by Cox proportional hazards model...
July 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28685553/application-of-oxaliplatin-in-combination-with-epirubicin-in-transcatheter-arterial-chemoembolization-in-the-treatment-of-primary-liver-carcinoma
#17
G Chang, L L Xie, W Y Li, F F Xia, P C Huang, Q R Liu, C D Zhang, T J Zhang, H F Li
Many cases of liver carcinoma miss the opportunity of surgical treatment because of hidden onset and delayed diagnosis. In recent years, interventional treatment has gradually become a non-surgical method for treating liver carcinoma. To discuss the effects of oxaliplatin in combination with epirubicin in the treatment and its influence on prognosis, this study randomly selected 218 advanced primary liver carcinoma patients from Binzhou People’s Hospital, Binzhou, China and divided them into a control group (n=109) and an observation group (n=109)...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28679433/long-term-survival-of-hepatocellular-carcinoma-after-percutaneous-radiofrequency-ablation-guided-by-ultrasound
#18
Weimin Zhang, Erping Luo, Jianhe Gan, Xiaomin Song, Zuowei Bao, Huiping Zhang, Minhua Chen
BACKGROUND: The risk factors for recurrence and death after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) remain poorly known. This study was aimed to study the 10-year overall survival (OS) of HCC treated by ultrasound (US)-guided RFA and the risk factors for recurrence and death. METHODS: Between June 2005 and June 2016, 1000 patients with HCC treated by US-guided RFA at 4 hospitals in China; among them, 525 patients met the criteria for radical ablation and 410 had high AFP levels before RFA treatment...
July 5, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28672190/a-novel-signal-on-photoelectrochemical-immunosensor-for-detection-of-alpha-fetoprotein-by-in-situ-releasing-electron-donor
#19
Jiexia Chen, Guang-Chao Zhao
A signal-on photoelectrochemical (PEC) immunosensor was constructed for detecting tumor marker in this work. α-fetoprotein (AFP) was chosen as a model analyte to investigate the prepared procedure and the analytical performance of the exploited sensor. In order to construct the sensor, CdSe QDs were used as photoactive material, biotin conjugated AFP antibody (Bio-anti-AFP) as detecting probe, streptavidin (SA) as signal capturing unit, biotin functionalized apoferritin encapsulated ascorbic acid (Bio-APOAA) as amplification unit, which were assembled onto the electrodes...
June 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28671377/afp-news-afp-edition
#20
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2017: American Family Physician
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