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https://www.readbyqxmd.com/read/28802749/enhanced-fluorescence-detection-of-proteins-using-zno-nanowires-integrated-inside-microfluidic-chips
#1
Lingxia Guo, Yuchen Shi, Xiangfei Liu, Zhitao Han, Zhenjie Zhao, Yong Chen, Wenhui Xie, Xin Li
Nanostructure-enhanced detection is promising for a number of applications such as early cancer diagnosis, environmental monitoring and mine safety, among which nanostructures integrated microfluidic chips offers unique advantage of ultra-low quantitative analyses. Here, dense ZnO nanowires of varied diameter and length were obtained by changing the content of polyethyleneimine (PEI) and growth time via simple hydrothermal growth in microfluidic channels for protein detection. We showed that this approach was superiorly efficient compared to the conventional hydrothermal method due to the flow-induced replenishment of nutrient and the effect of shear stress...
August 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28801286/-value-of-detection-of-serum-glypican-3-level-in-diagnosis-and-therapeutic-effect-evaluation-of-primary-hepatocellular-carcinoma
#2
Yuan-Yuan Wang, Chen-Jie Zhou, Jing Li, Ling Zhou, Ming-Song Li, Bing Xiao
OBJECTIVE: To explore the clinical value of detecting serum glypican-3 in the diagnosis and therapeutic effect evaluation of primary hepatocellular carcinoma (PHC). METHODS: Using sandwich ELISA, we detected serum glypican-3 levels in 60 patients with PHC, 60 with metastatic liver cancer, 50 with liver cirrhosis, 50 with chronic viral hepatitis, 20 with hepatic cyst, 20 with fatty liver, 20 with hepatic hemangioma and 20 with drug-induced hepatitis as well as in 40 healthy subjects (control)...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28798939/orphan-nuclear-receptor-tr3-nur77-is-a-specific-therapeutic-target-for-hepatic-cancers
#3
Yingling Zeng, Xiaoguang Ye, Degui Liao, Shizhang Huang, Huinan Mao, Dezheng Zhao, Huiyan Zeng
OBJECTIVE: Although great success has been achieved in cancer treatment, current cancer therapies, including anti-tumorigenesis and anti-angiogenesis, still face the problems of insufficient efficacy, resistance and intrinsic refractoriness, in addition to their toxic side effects. There is a demand to identify additional targets that can be blocked to turn off the downstream effects of most, if not all, pathways. Our previous studies suggest that orphan nuclear receptor TR3 (human) / Nur77 (mouse) is such a target...
June 2017: Journal of Clinical & Experimental Oncology
https://www.readbyqxmd.com/read/28797106/the-risks-of-hepatocellular-carcinoma-development-after-hcv-eradication-are-similar-between-patients-treated-with-peg-interferon-plus-ribavirin-and-direct-acting-antiviral-therapy
#4
Yuko Nagaoki, Michio Imamura, Hiroshi Aikata, Kana Daijo, Yuji Teraoka, Fumi Honda, Yuki Nakamura, Masahiro Hatooka, Reona Morio, Kei Morio, Hiromi Kan, Hatsue Fujino, Tomoki Kobayashi, Keiichi Masaki, Atsushi Ono, Takashi Nakahara, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Yoshiiku Kawakami, C Nelson Hayes, Daiki Miki, Hidenori Ochi, Kazuaki Chayama
The risk of hepatocellular carcinoma (HCC) development is reduced following viral elimination by interferon therapy in chronic hepatitis C patients. However, the risk in patients treated with interferon-free direct-acting antivirals (DAAs) is unknown. We evaluated chronic hepatitis C patients who achieved viral eradication by pegylated-interferon plus ribavirin (PEG-IFN/RBV, n = 244) or daclatasvir plus asunaprevir (DCV/ASV, n = 154) therapy. None of the patients had prior history of HCC or antiviral therapy...
2017: PloS One
https://www.readbyqxmd.com/read/28796412/clinical-significance-of-half-lives-of-the-tumor-markers-alpha-fetoprotein-and-des-%C3%AE-carboxy-prothrombin-after-hepatectomy-for-hepatocellular-carcinoma
#5
Masayo Tsukamoto, Hidetoshi Nitta, Katsunori Imai, Takaaki Higashi, Nakagawa Shigeki, Hirohisa Okabe, Kota Arima, Takayoshi Kaida, Katsunobu Taki, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba
AIM: The prognostic significance of the half-lives (HLs) of alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) in patients undergoing hepatectomy for hepatocellular carcinoma (HCC) is unclear. We evaluated the HLs of AFP and DCP in a cohort of such patients. METHODS: This study included data on 202 patients with HCC who underwent curative hepatectomy and had preoperative AFP concentrations ≥ 100 ng/mL or DCP ≥ 200 mAU/mL. We calculated the HLs of AFP and DCP from their values just before and one month after hepatectomy...
August 10, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28795996/initial-alpha-fetoprotein-response-predicts-prognosis-in-hepatitis-b-related-solitary-hcc-patients-after-radiofrequency-ablation
#6
Su Jong Yu, Jee Hye Kwon, Won Kim, Jung-Hwan Yoon, Jeong Min Lee, Jae Young Lee, Eun Ju Cho, Jeong-Hoon Lee, Hwi Young Kim, Yong Jin Jung, Yoon Jun Kim
BACKGROUND: Radiofrequency ablation (RFA) is effective for early-stage hepatocellular carcinoma but recurrence is problem. GOALS: To identify prognostic factors including alpha-fetoprotein (AFP) for overall survival and intrahepatic recurrence after RFA. PATIENTS AND METHODS: Not only naïve but also previously treated patients with solitary hepatitis B virus-related hepatocellular carcinoma <5 cm were prospectively enrolled and a ≥50% decrease from baseline to 1 month after RFA was defined as an initial AFP response...
August 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28792511/aldehyde-dehydrogenase-1-aldh1-isoform-expression-and-potential-clinical-implications-in-hepatocellular-carcinoma
#7
Cheng-Kun Yang, Xiang-Kun Wang, Xi-Wen Liao, Chuang-Ye Han, Ting-Dong Yu, Wei Qin, Guang-Zhi Zhu, Hao Su, Long Yu, Xiao-Guang Liu, Si-Cong Lu, Zhi-Wei Chen, Zhen Liu, Ke-Tuan Huang, Zheng-Tao Liu, Yu Liang, Jian-Lu Huang, Kai-Yin Xiao, Min-Hao Peng, Cheryl Ann Winkle, Stephen J O'Brien, Tao Peng
Hepatocellular carcinoma (HCC) is one of the most prevalent and life-threatening malignancies worldwide. There are few diagnostic and prognostic biomarkers and druggable targets for HCC. Aldehyde dehydrogenase 1 (ALDH1) is a marker of stem cells in a variety of cancers, but the mRNA levels and prognostic value of ALDH1 isoforms in HCC patients remain unknown. In the present study, gene ontology annotation of the ALDH1 family was performed using the Database for Annotation, Visualization and Integrated Discovery (DAVID), and the gene pathway analsis was performed using GeneMANIA software...
2017: PloS One
https://www.readbyqxmd.com/read/28792091/the-combination-of-mir-122-overexpression-and-let-7f-silencing-induce-hepatic-differentiation-of-adipose-tissue-derived-stem-cells
#8
Nahid Davoodian, Abbas S Lotfi, Masoud Soleimani, Hori Ghaneialvar
Human adipose tissue-derived stem cells (hADSCs) have been considered as a promising source for cell therapy of liver diseases due to their accessibility, abundance and expression of hepatocyte markers. Currently, the important role of certain microRNAs (miRNAs) has been reported during hepatic differentiation of stem cells. However, the combination effect of miRNAs on hepatic differentiation of these cells needs to be more investigated. The present study seeks to determine whether the combination of miRNAs can enhance hepatic differentiation of hADSCs in the absence of any other stimulation...
August 9, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28790549/genetic-counseling-and-prenatal-diagnosis-of-triploidy-during-the-second-trimester-of-pregnancy
#9
Milenko Kolarski, Begzudin Ahmetovic, Maja Beres, Radomir Topic, Vedran Nikic, Ivana Kavecan, Semin Sabic
INTRODUCTION: Triploidy is a lethal chromosomal numeric abnormality, characterized on extra haploid set of chromosomes. It occurs in 2 to 3% of conceptuses and accounts for approximately 20% of chromosomally abnormal first-trimester miscarriages. As such, triploidy is estimated to occur in 1 of 3,500 pregnancies at 12 weeks', 1 in 30,000 at 16 weeks', and 1 in 250,000 at 20 weeks' gestation. CASE REPORT: We present a case of second-trimester triploidy diagnosed prenataly at our center...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28781800/clinicopathological-and-prognostic-characteristics-in-patients-with-afp-secreting-gastric-carcinoma
#10
Yakup Bozkaya, Nebi Serkan Demirci, Alican Kurtipek, Gökmen Umut Erdem, Nuriye Yildirim Ozdemir, Nurullah Zengin
The aim of the present study was to determine whether there are any clinicopathological or prognostic differences between patients with α-fetoprotein-secreting gastric carcinoma (AFP-SGC) and non-AFP-SGC. Pathological parameters, clinical parameters, and treatment efficacy were compared in patients with AFP-SGC and non-AFP-SGC. In total, 362 patients (53 with AFP-SGC and 309 with non-AFP-SGC) were included in the present study. Patients with AFP-SGC had significantly higher levels of lymphovascular invasion, perineural invasion (PNI), rate of liver metastasis, and stage IV cancer compared with patients with non-AFP-SGC (P<0...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28770990/multiplex-immunochips-for-high-accuracy-detection-of-afp-l3-based-on-surface-enhanced-raman-scattering-implications-for-early-liver-cancer-diagnosis
#11
Hao Ma, Xiaoying Sun, Lei Chen, Weina Cheng, Xiao Xia Han, Bing Zhao, Chengyan He
α-Fetoprotein (AFP) is an important tumor biomarker. In particular, the overexpression of AFP-L3 is associated with hepatocellular carcinoma (HCC). Accordingly, several hospitals have begun to employ the ratio of AFP-L3 to the total AFP level (AFP-L3%) as new diagnostic evidence for HCC owing to its high diagnostic accuracy. However, current methods of detection for AFP and AFP-L3 are time-consuming, require multiple samples, and lack in sensitivity and specificity. Herein, we present a novel concept for the early diagnosis of HCC based on the combination of Raman frequency shift and intensity change, and developed surface-enhanced Raman scattering (SERS)-based immunochips via AFP-L3%...
August 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28770532/validation-of-a-simple-scoring-system-to-predict-sorafenib-effectiveness-in-patients-with-hepatocellular-carcinoma
#12
Giovan Giuseppe Di Costanzo, Andrea Casadei Gardini, Giorgia Marisi, Francesco Giuseppe Foschi, Mario Scartozzi, Rocco Granata, Luca Faloppi, Stefano Cascinu, Nicola Silvestris, Oronzo Brunetti, Vincenzo Ostilio Palmieri, Giorgio Ercolani, Raffaella Tortora
BACKGROUND: Sorafenib is recommended for the treatment of advanced-stage hepatocellular carcinoma (HCC). Nonetheless, it is expensive, effective in few patients, and may cause significant adverse effects. Therefore, accurate selection of patients is needed. In a previous study, we constructed a simple scoring system to predict patients' outcomes based on the occurrence of sorafenib adverse effects. OBJECTIVE: The present study aimed to validate this scoring system in a real-life cohort of HCC patients...
August 3, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28767284/commutability-of-reference-materials-for-%C3%AE-fetoprotein-in-human-serum
#13
Yuhong Yue, Shunli Zhang, Zhenzhen Xu, Xi Chen, Qingtao Wang
CONTEXT: - Reliable quantification of α-fetoprotein (AFP) is critical for clinical diagnosis. Accuracy in AFP analysis relies on traceability to reference materials with confirmed commutability. OBJECTIVE: - To assess the commutability of the reference materials for AFP. We screened for appropriate reference materials for the calibration of clinical AFP analysis and for application in an external quality assessment scheme. The feasibility of using water to dilute a reference material from the World Health Organization was also evaluated...
August 2, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28765910/evi5-is-a-novel-independent-prognostic-predictor-in-hepatocellular-carcinoma-after-radical-hepatectomy
#14
Jintian Tang, Jianghua Ou, Chunyan Xu, Chao Yi, Feng Xue, Lin Xu, Fenju Lai, Jianjun Tang, Shengping Li, Tiebang Kang, Wei Ding, Boqing Wang
The present study explored the correlation of ecotropic viral integration site 5 (EVI5) expression with clinicopathological features and prognosis in hepatocellular carcinoma (HCC). A total of 205 HCC patients were included retrospectively. Quantitative real-time polymerase chain reaction (RT-qPCR) and western blotting were performed to detect the profile of EVI5 expression in HCC cell lines and fresh tissues. Archived paraffin-embedded specimens were investigated for EVI5 expression by immunohistochemistry (IHC)...
August 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28764583/expression-and-significance-of-aquaporin-2-and-serum-hormones-in-placenta-of-patients-with-preeclampsia
#15
Yurong Zhao, Li Lin, Ailuan Lai
To evaluate the relationship between serum hormone or aquaporin-2 (AQP-2) and preeclampsia, patients with severe preeclampsia (A group), mild preeclampsia (B group), chronic hypertension (C group) and normal pregnant women (D group) were recruited and analysed. The AQP-2 level in placenta tissues was detected and the correlations of AQP-2 with serum hormone levels were analysed using linear correlation regression analysis. The differences of alpha foetal protein (AFP) and human chorionic gonadotropin (HCG) levels during mid-pregnancy, as well as the levels of AFP, HCG, unconjugated oestriol and progesterone during late pregnancy were significant among A, B, C and D groups (p < ...
August 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28762703/aafp-news-afp-edition
#16
(no author information available yet)
No abstract text is available yet for this article.
July 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28762692/aafp-news-afp-edition
#17
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28759960/low-expression-of-nek2-is-associated-with-hepatocellular-carcinoma-progression-and-poor-prognosis
#18
Luoqin Fu, Suxia Liu, Huiju Wang, Yingyu Ma, Li Li, Xianglei He, Xiaozhou Mou, Xiangmin Tong, Zhiming Hu, Guoqing Ru
BACKGROUND: NIMA-related kinase 2 (NEK2), a serine/threonine kinase, is located in the centrosome and is a member of cell cycle regulation related protein kinase (CCRK) family. Aberrant expression of NEK2 is linked with carcinogenesis and progression of various tumors. OBJECTIVE: To investigate the expression level of NEK2 and its relationship with clinicopathological factors in hepatocellular carcinoma (HCC). METHODS: Immunohistochemistry was used to measure the expression of NEK2 in 310 patients' specimen tissues and 197 adjacent normal liver tissues of HCC cases, and the subsequent prognostic value for each sample was estimated...
July 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28759952/expression-and-genetic-polymorphism-of-necroptosis-related-protein-ripk1-is-correlated-with-severe-hepatic-ischemia-reperfusion-injury-and-prognosis-after-hepatectomy-in-hepatocellular-carcinoma-patients
#19
Chen Yao, Gang Li, Ming Cai, Yeyong Qian, Liqin Wang, Li Xiao, Friedrich Thaiss, Bingyi Shi
OBJECTIVES: The goal of our study was to assess the prognostic impact of the necroptosis relative protein RIPK1 genetic polymorphism in ischemia-reperfusion injury and survival after hepatectomy in hepatocellular carcinoma (HCC) patients. METHODS: In this study, expression of RIPK1 and its genetic polymorphism(rs2272990) were examined in plasma of 44 HCC patients. All these patients were undergoing partial hepatectomy. The prognostic values of RIPK1 genetic polymorphism for tumor development and survival, and ischemia-reperfusion injury after hepatectomy were further determined...
July 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28759869/shell-encoded-au-nanoparticles-with-tunable-electroactivity-for-specific-dual-disease-biomarkers-detection
#20
Yuan Zhao, Yaxin Yang, Yali Sun, Linyan Cui, Fangjie Zheng, Jiru Zhang, Qijun Song, Chuanlai Xu
The exploration of electroactive labelling with tailorable and strong differential pulse voltammetry (DPV) responses is of great importance in accurate and sensitive screening of a panel of biomarkers related to cancer. Herein, shell-encoded gold nanoparticles (Au NPs) are fabricated and give rise to shell species-dominated DPV peak potentials. Two independent DPV peaks appear at -0.08V for Au@Cu2O core-shell NPs and 0.26V for Au@Ag core-shell NPs. Shell-encoded Au NPs drastically exhibit shell thickness-tunable amplified peak currents...
July 26, 2017: Biosensors & Bioelectronics
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