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https://www.readbyqxmd.com/read/28944659/t2-weighted-mr-imaging-of-hepatic-tumor-guided-by-spio-loaded-nanostructured-lipid-carriers-and-ferritin-reporter-genes
#1
Chenying Lu, Jiansong Ji, Xiuliang Zhu, Peifeng Tang, Qian Zhang, Nannan Zhang, Zuhua Wang, Xiaojuan Wang, Weiqian Chen, Jingbo Hu, Yongzhong Du, Risheng Yu
Nowadays, there is a high demand for supersensitive contrast agents for the early diagnostics of hepatocarcinoma. It has been recognized that accurate imaging information is able to be achieved by constructing hepatic tumor specific targeting probes, though it still faces challenges. Here, A AGKGTPSLETTP peptide (A54) functionalized superparamagnetic iron oxide (SPIO)-loaded nanostructured lipid carrier (A54-SNLC), which can be specifically uptaken by hepatoma carcinoma cell (Bel-7402) and exhibited ultralow imaging signal intensity with varied Fe concentration on T2-weighted imaging (T2WI), was first prepared as an effective gene carrier...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28943903/high-expression-of-gp73-in-primary-hepatocellular-carcinoma-and-its-function-in-the-assessment-of-transcatheter-arterial-chemoembolization
#2
Ning Ai, Wei Liu, Zhi-Gang Li, Hong Ji, Bo Li, Guang Yang
Golgi glycoprotein 73 (GP73) is a type II Golgi transmembrane protein and a potential novel marker for the diagnosis of primary hepatocellular carcinoma (PHC). However, its reliability as a serum marker for the diagnosis of PHC following transcatheter arterial chemoembolization (TACE) remains unknown. The aim of the present study was to evaluate the diagnostic value of serum GP73 levels in patients with PHC, to determine its diagnostic accuracy in patients with PHC following TACE. Reverse transcription-quantitative polymerase chain reaction analysis was used to measure GP73 expression in PHC and adjacent para-carcinomatous liver tissue in 40 patients with PHC, and 15 normal liver samples from benign hepatic tumors...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28941728/preoperative-prediction-of-microvascular-invasion-in-hepatocellular-carcinoma-using-quantitative-image-analysis
#3
Jian Zheng, Jayasree Chakraborty, William C Chapman, Scott Gerst, Mithat Gonen, Linda M Pak, William R Jarnagin, Ronald P DeMatteo, Richard Kg Do, Amber L Simpson, Peter J Allen, Vinod P Balachandran, Michael I D'Angelica, T Peter Kingham, Neeta Vachharajani
BACKGROUND: Microvascular invasion (MVI) is a significant risk factor for early recurrence after resection or transplantation for hepatocellular carcinoma (HCC). Knowledge of MVI status would help guide treatment recommendations but is generally identified after surgery. This study aims to predict MVI preoperatively using quantitative image analysis. STUDY DESIGN: From 2 institutions, 120 patients submitted to resection of HCC from 2003 to 2015 were included. The largest tumor from preoperative CT was subjected to quantitative image analysis, which uses an automated computer algorithm to capture regional variation in CT enhancement patterns...
September 20, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28939487/plasma-heat-shock-protein-90alpha-as-a-biomarker-for-the-diagnosis-of-liver-cancer-an-official-large-scale-and-multicenter-clinical-trial
#4
Yan Fu, Xiao Xu, Dongsheng Huang, Dawei Cui, Lisheng Liu, Junwei Liu, Zenglei He, Jingjing Liu, Shusen Zheng, Yongzhang Luo
More sensitive biomarker is urgently needed to reduce the mortality caused by the worldwide prevalent liver cancer. This study aims to assess whether quantitative measurement of heat shock protein 90alpha (Hsp90α) in plasma can improve the diagnosis accuracy and monitor treatment response of liver cancer patients. We analyzed the data from an official (registered at ClinicalTrial.gov: NCT02324127), large-scale (1647 enrollments), and multicenter (three independent hospitals) clinical trial, which quantitatively measured plasma Hsp90α by ELISA for patients with liver cancer, patients with at-risk liver diseases (including hepatitis, liver cirrhosis, focal nodular hyperplasia), and healthy individuals...
September 12, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28939160/hepatocellular-carcinoma-with-neuroendocrine-differentiation-a-case-report
#5
Jiajie G Lu, M Aabid Farukhi, Donna Mayeda, Samuel W French
Hepatocellular carcinoma with neuroendocrine differentiation, where tumor cells stain for both hepatocellular and neuroendocrine markers, is extremely rare. We report a case of a 65-year-old man who presented with a 14-cm rapidly growing mass in the right lobe of his liver with local extension into the gallbladder and portal vein. Serum AFP was 4625ng/mL. Liver biopsy showed a poorly differentiated neoplasm with cells showing nuclear pleomorphism, high nuclear/cytoplasmic ratio, and numerous mitoses. The tumor cells stain for AFP, glutamine synthase, arginase, and glypican-3...
September 19, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28938566/screening-differential-circular-rna-expression-profiles-reveals-hsa_circ_0004018-is-associated-with-hepatocellular-carcinoma
#6
Liyun Fu, Ting Yao, Qingqing Chen, Xiaoyan Mo, Yaoren Hu, Junming Guo
Circular RNAs (circRNAs) have been emerged as an indispensable part of endogenous RNA network. However, the expression significance of circRNAs in hepatocellular carcinoma (HCC) is rarely revealed. The aim of this study was to determine the circRNA expression profile in HCC, and to investigate their clinical significances and relevant mechanisms for cancer progression. The global circRNA expression profile in HCC was measured by circRNA microarray. Levels of one representative circRNAs, hsa_circ_0004018, were confirmed by real-time reverse transcription-polymerase chain reaction...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936355/theoretical-and-experimental-study-of-the-antifreeze-protein-afp752-trehalose-and-dimethyl-sulfoxide-cryoprotection-mechanism-correlation-with-cryopreserved-cell-viability
#7
Irena Kratochvílová, Martin Golan, Karel Pomeisl, Jan Richter, Silvia Sedláková, Jakub Šebera, Júlia Mičová, Martin Falk, Iva Falková, David Řeha, K Wade Elliott, Krisztina Varga, Shelby E Follett, Daniel Šimek
In this work the physico-chemical properties of selected cryoprotectants (antifreeze protein TrxA-AFP752, trehalose and dimethyl sulfoxide) were correlated with their impact on the constitution of ice and influence on frozen/thawed cell viability. The freezing processes and states of investigated materials solutions were described and explained from a fundamental point of view using ab-initio modelling (molecular dynamics, DFT), Raman spectroscopy, Differential Scanning Calorimetry and X-Ray Diffraction. For the first time, in this work we correlated the microscopic view (modelling) with the description of the frozen solution states and put these results in the context of human skin fibroblast viability after freezing and thawing...
2017: RSC Advances
https://www.readbyqxmd.com/read/28928842/significant-response-to-ramucirumab-monotherapy-in-chemotherapy-resistant-recurrent-alpha-fetoprotein-producing-gastric-cancer-a-case-report
#8
Yasuhiro Arakawa, Miho Tamura, Keisuke Aiba, Kazuhiko Morikawa, Daisuke Aizawa, Masahiro Ikegami, Masami Yuda, Katsunori Nishikawa
Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) is a relatively rare type of gastric cancer characterized by a high incidence of liver and lymph node metastases, and a poor prognosis. Few advanced AFPGC cases treated successfully with conventional chemotherapy have been reported thus far. Although the development of molecular-targeted therapy has improved the prognosis of various types of cancer, there are currently no tailored therapies for AFPGC. In the present report, the case of a chemotherapy-resistant recurrent AFPGC patient who exhibited a significant response to ramucirumab monotherapy is presented...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928396/balance-between-hydration-enthalpy-and-entropy-is-important-for-ice-binding-surfaces-in-antifreeze-proteins
#9
Michael Schauperl, Maren Podewitz, Teresa S Ortner, Franz Waibl, Alexander Thoeny, Thomas Loerting, Klaus R Liedl
Antifreeze Proteins (AFPs) inhibit the growth of an ice crystal by binding to it. The detailed binding mechanism is, however, still not fully understood. We investigated three AFPs using Molecular Dynamics simulations in combination with Grid Inhomogeneous Solvation Theory, exploring their hydration thermodynamics. The observed enthalpic and entropic differences between the ice-binding sites and the inactive surface reveal key properties essential for proteins in order to bind ice: While entropic contributions are similar for all sites, the enthalpic gain for all ice-binding sites is lower than for the rest of the protein surface...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927298/prognostic-value-of-perfusion-ct-in-hepatocellular-carcinoma-treatment-with-sorafenib-comparison-with-mrecist-in-longitudinal-follow-up
#10
Sascha Kaufmann, Wolfgang M Thaiss, Maximilian Schulze, Michael Bitzer, Ulrich Lauer, Konstantin Nikolaou, Marius Horger
Background Targeted therapies are of increasing clinical importance and classic radiologic therapy response-criteria often fail to detect early therapeutic response or failure. For hepatocellular carcinoma (HCC), this is of major importance as therapeutic options are limited. Purpose To investigate the impact of sorafenib-treatment on intralesional perfusion using perfusion computed tomography (PCT) in HCC and to correlate the observed changes with mRECIST and the course of serum alpha-fetoprotein (AFP) for identification of their prognostic value...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28926899/-the-quantitative-analysis-of-mr-dynamic-contrast-enhangced-imaging-on-efficacy-and-prognosis-of-transcatheter-arterial-chemoembolization-on-hepatocellular-carcinoma
#11
X H Ma, S Wang, X M Zhao, H Ouyang, M Wang, Y J Zhu, Z Zhu, C W Zhou
Objective: To investigate the prognostic value of quantitative parameters of dynamic contrast-enhangced MR (DCE-MR) on short-term efficacy of transcatheter arterial chemoembolization (TACE) on hepatocellular carcinoma(HCC). Methods: 79 patients with HCC underwent non-enhanced MR imaging and DCE on a 3.0T MR scanner before and one month after TACE. The quantitative parameters were measured on the maximal tumor region, including maximal tumor diameter(MTD), ADC, K(trans,) K(ep) and V(e) value before and after TACE...
September 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28925670/aafp-news-afp-edition
#12
(no author information available yet)
No abstract text is available yet for this article.
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925653/aafp-news-afp-edition
#13
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925640/aafp-news-afp-edition
#14
(no author information available yet)
No abstract text is available yet for this article.
September 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28922374/fractional-laser-exposure-induces-neutrophil-infiltration-n1-phenotype-into-the-tumor-and-stimulates-systemic-anti-tumor-immune-response
#15
Masayoshi Kawakubo, Shadmehr Demehri, Dieter Manstein
BACKGROUND: Ablative fractional photothermolysis (aFP) using a CO2 laser generates multiple small diameter tissue lesions within the irradiation field. aFP is commonly used for a wide variety of dermatological indications, including treatment of photodamaged skin and dyschromia, drug delivery and modification of scars due to acne, surgical procedures and burns. In this study we explore the utility of aFP for treating oncological indications, including induction of local tumor regression and inducing anti-tumor immunity, which is in marked contrast to current indications of aFP...
2017: PloS One
https://www.readbyqxmd.com/read/28921586/down-syndrome-maternal-serum-markers-in-oocyte-donation-and-other-assisted-reproductive-technologies
#16
Aurore Bonnin, Françoise Muller, Marie-Victoire Senat, Corinne Sault, Armelle Galland, Joëlle Taieb, Sophie Dreux, Jean Bouyer, Alexandra Benachi
OBJECTIVE: Because maternal serum markers (PAPP-A, hCGβ, and AFP) used for Down syndrome (DS) screening have been described as predictors of obstetrical complications and because assisted reproductive technology (ART) pregnancies are known to be at increased risk for obstetrical complications, it is unclear whether or not correction factors should be applied to the calculated risk of DS. The purpose of this study was to evaluate DS maternal serum markers in oocyte donation (OD) and ART pregnancies in comparison with natural pregnancies...
September 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28920172/hepatocellular-carcinoma-screening-utilising-serum-alpha-fetoprotein-measurement-and-abdominal-ultrasound-is-more-effective-than-ultrasound-alone-in-patients-with-non-viral-cirrhosis
#17
Thomas Worland, Benjamin Harrison, Leighton Delmenico, Damian Dowling
PURPOSE: This study is aimed to determine the performance of alpha-fetoprotein (AFP) as part of hepatocellular carcinoma (HCC) screening in a non-viral cirrhosis population. METHODS: A retrospective audit was conducted of patients with non-viral cirrhosis over a 13 year period managed at a single centre. All patients were investigated routinely for evidence of viral hepatitis; patients with positive results were excluded from analysis. Cirrhosis was defined on basis of clinical, biochemical, and radiological investigations and examinations...
September 17, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28917768/gold-nanoparticle-labeling-with-tyramide-signal-amplification-for-highly-sensitive-detection-of-alpha-fetoprotein-in-human-serum-by-icp-ms
#18
Xiaoting Li, Beibei Chen, Man He, Guangyang Xiao, Bin Hu
In this work, we developed an immunoassay based on tyramide signal amplification (TSA) and gold nanoparticles (Au NPs) labeling for highly sensitive detection of alpha fetoprotein (AFP) by inductively coupled plasma mass spectrometry (ICP-MS). AFP was captured by anti-AFP1 coating on the 96-well plate and labeled by anti-AFP2-horseradish peroxidase (HRP), in which the HRP can catalyze the deposition of biotinylated tyramine on the nearby protein. Then the streptavidin (SA)-Au NPs was labeled on the deposited biotinylated tyramine as the intensive signal probe for ICP-MS measurement...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28915507/ambient-fine-particulate-matters-induce-cell-death-and-inflammatory-response-by-influencing-mitochondria-function-in-human-corneal-epithelial-cells
#19
Eun-Jung Park, Jae-Byoung Chae, Jungmook Lyu, Cheolho Yoon, Sanghwa Kim, Changjoo Yeom, Younghun Kim, Jaerak Chang
Ambient fine particulate matter (AFP) is a main risk factor for the cornea as ultraviolet light. However, the mechanism of corneal damage following exposure to AFP has been poorly understood. In this study, we first confirmed that AFP can penetrate the cornea of mice, considering that two-dimensional cell culture systems are limited in reflecting the situation in vivo. Then, we investigated the toxic mechanism using human corneal epithelial (HCET) cells. At 24h after exposure, AFP located within the autophagosome-like vacuoles, and cell proliferation was clearly inhibited in all the tested concentration...
September 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/28904728/evaluation-of-the-acute-flaccid-paralysis-afp-surveillance-system-gokwe-north-district-zimbabwe-2015-a-descriptive-cross-sectional-study
#20
Annamercy Makoni, Milton Chemhuru, Notion Gombe, Gerald Shambira, Tsitsi Juru, Donewell Bangure, Mufuta Tshimanga
INTRODUCTION: AFP surveillance was adopted globally as a key strategy for monitoring the progress of the polio eradication initiative. Gokwe North district with an estimated 119 655 children <15 years detected 2 cases, 4 cases and 1 case of AFP in 2012, 2013 and 2014 respectively against a target of 5 cases per year. We therefore set out to evaluate the system and find out why it was failing to detect at least 5 cases per year. METHODS: A descriptive cross sectional study was carried out...
2017: Pan African Medical Journal
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