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https://www.readbyqxmd.com/read/28211941/upfront-window-vincristine-irinotecan-treatment-of-high-risk-hepatoblastoma-a-report-from-the-children-s-oncology-group-ahep0731-study-committee
#1
Howard M Katzenstein, Wayne L Furman, Marcio H Malogolowkin, Mark D Krailo, M Beth McCarville, Alexander J Towbin, Greg M Tiao, Milton J Finegold, Sarangarajan Ranganathan, Stephen P Dunn, Max R Langham, Eugene D McGahren, Carlos Rodriguez-Galindo, Rebecka L Meyers
BACKGROUND: The identification of new therapies for high-risk (HR) hepatoblastoma is challenging. Children's Oncology Group study AHEP0731 included a HR stratum to explore the efficacy of novel agents. Herein, the authors report the response rate to the combination of vincristine (V) and irinotecan (I) and the outcome of patients with high-risk hepatoblastoma. METHODS: Patients with newly diagnosed metastatic hepatoblastoma or those with a serum α-fetoprotein (AFP) level <100 ng/mL were eligible...
February 17, 2017: Cancer
https://www.readbyqxmd.com/read/28211917/concentration-dependent-oligomerization-of-an-alpha-helical-antifreeze-polypeptide-makes-it-hyperactive
#2
Sheikh Mahatabuddin, Yuichi Hanada, Yoshiyuki Nishimiya, Ai Miura, Hidemasa Kondo, Peter L Davies, Sakae Tsuda
A supersoluble 40-residue type I antifreeze protein (AFP) was discovered in a righteye flounder, the barfin plaice (bp). Unlike all other AFPs characterized to date, bpAFP transitions from moderately-active to hyperactive with increasing concentration. At sub-mM concentrations, bpAFP bound to pyramidal planes of ice to shape it into a bi-pyramidal hexagonal trapezohedron, similarly to the other moderately-active AFPs. At mM concentrations, bpAFP uniquely underwent further binding to the whole ice crystal surface including the basal planes...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209416/efficacy-of-an-anal-fistula-plug-for-fistulas-in-ano-in-children
#3
Katsunori Kouchi, Ayao Takenouchi, Aki Matsuoka, Kiyoaki Yabe, Mashahiro Korai, Chikako Nakata
BACKGROUND: In children, perianal abscesses have a good prognosis and often heal with age. However, some perianal abscesses are refractory to treatment and remain as fistulas-in-ano. Treatment with a Surgisis Anal Fistula Plug® has been reported as a new method of treatment for fistulas. In adults, the plug has been reported to cause little pain and have a high cure rate, but there have been no reported cases of its use in children. PURPOSE: This study was designed to analyze the efficacy of the plug for closure of refractory fistulas in children...
February 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28208001/predictive-factors-for-complete-response-and-recurrence-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#4
Shin Ok Jeong, Eui Bae Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Sang Gyune Kim, Sang Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Dong Erk Goo, Su Yeon Park
Background/Aims: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Methods: Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS). Results: Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43...
February 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28207681/significance-of-glypican-3-gpc3-expression-in-hepatocellular-cancer-diagnosis
#5
Bin Sun, Zhi Huang, Bi Wang, Yanglong Yu, Shihai Lin, Lei Luo, Yuzhu Wang, Zheng Huang
BACKGROUND Primary hepatocellular carcinoma (HCC) is a malignant tumor that is common China. Early diagnosis is of great significance for improving treatment efficiency. GPC3 level is closely related to HCC occurrence. This study investigated GPC3 expression in HCC patient serum and tissue, and assessed the significance of GPC3 combined AFP detection in HCC diagnosis. MATERIAL AND METHODS A total of 76 HCC patients in our hospital were enrolled. Immunohistochemistry was applied to test GPC3 expression in cancer tissue and para-carcinoma tissue...
February 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28206673/the-immune-system-as-a-new-possible-cell-target-for-afp-464-in-a-spontaneous-mammary-cancer-mouse-model
#6
Mariana A Callero, Cristina E Rodriguez, Aldana Sólimo, Elisa Bal de Kier Joffé, Andrea I Loaiza Perez
Aminoflavone (AFP 464, NSC 710464), an antitumor agent which recently entered phase II clinical trials, acts against estrogen-positive breast cancer (ER +). AFP 464, which has a unique mechanism of action by activating aryl hydrocarbon receptor (AhR) signaling pathway, decreased tumor size and growth rate in the estrogen dependent, Tamoxifen-sensitive spontaneous M05 mouse model. Considering that AhR has recently emerged as a physiological regulator of the innate and adaptive immune responses, we investigated whether AFP 464 modulates the immune response in our mouse model...
February 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28198625/curcumin-attenuates-n-nitrosodiethylamine-induced-liver-injury-in-mice-by-utilizing-the-method-of-metabonomics
#7
Peiyu Qiu, Jiachen Sun, Shuli Man, He Yang, Long Ma, Peng Yu, Wenyuan Gao
N-Nitrosodiethylamine (DEN) as one of food additives existed in cheddar cheese, processed meats, beer, water and so forth. It possessed a potent hepatocarcinogen in animals and humans. Curcumin as a natural dietary compound decreased DEN-induced hepatocarcinogenesis in this research. According to the histopathological examination macroof liver tissues, and biomarker detection in serum and livers, it demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level and COX-2/PGE2 pathway...
February 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28198497/nested-polymerase-chain-reaction-technique-for-the-detection-of-gpc3-and-afp-mrna-in-liver-cancer-micrometastases
#8
J Luo, K Yang, Y G Wen
The incidence of liver cancer has gradually risen to a high level in China, and tumor metastasis occurs via multiple pathways. Alpha fetal protein (AFP) is the main biomarker of liver cancer micrometastases. A recent study showed that glypican-3 (GPC3), which is abundant in hepatoma cells, has promising specificity and could be used to determine the presence of malignant cells. The nested polymerase chain reaction (PCR) technique is superior in experimental sensitivity. Using rat models of liver cancer in the current study, we utilized nested PCR to detect Gpc3 and Afp mRNA to determine their relationship with liver cancer micrometastases...
February 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28194604/hepatocellular-carcinoma-biology-predicts-survival-outcome-after-liver-transplantation-in-the-usa
#9
Mohamed Abd El-Fattah
PURPOSE: The aim of this study is to evaluate the clinicopathologic prognostic factors of cancer-specific survival (CSS) in hepatocellular carcinoma (HCC) patients who underwent liver transplantation (LT) stratified by tumor size. METHODS: From the Surveillance, Epidemiology, and End Results (SEER) 18 registries (2004-2012), we retrieved data of 570 patients who underwent LT for a solitary primary HCC lesion ≤5 cm. A two multivariable Cox models were constructed to identify prognostic factors of CSS in a two different tumor sizes (2 cm cutoff)...
February 14, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28194091/establishment-and-characterization-of-a-novel-highly-aggressive-gallbladder-cancer-cell-line-tj-gbc2
#10
Zhong-Yan Liu, Guo-Li Xu, Hui-Hong Tao, Yao-Qin Yang, Yue-Zu Fan
BACKGROUND: Human gallbladder cancer (GBC) is an aggressive malignant neoplasm with a poor prognosis. The development of ideal tools for example tumor cell lines for investigating biological behavior, metastatic mechanism and potential treatment in GBCs is essential. In present study, we established and characterized a GBC cell line derived from primary tumor. METHODS: Primary culture method was used to establish this cell line from a primary GBC. Light and electron microscopes, flow cytometry, chromosome analysis, heterotransplantation and immunohistochemistry were used to characterize the epidemic tumor characteristics and phenotypes of this cell line...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28188748/association-between-high-avidity-t-cell-receptors-induced-by-alpha-fetoprotein-derived-peptides-and-anti-tumor-effects-in-patients-with-hepatocellular-carcinoma
#11
Hidetoshi Nakagawa, Eishiro Mizukoshi, Eiji Kobayashi, Toshikatsu Tamai, Hiroshi Hamana, Tatsuhiko Ozawa, Hiroyuki Kishi, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Atsushi Muraguchi, Shuichi Kaneko
BACKGROUND & AIMS: Levels of alpha fetoprotein (AFP) are measured for surveillance and diagnosis of hepatocellular carcinoma (HCC). We performed a phase 1 trial to evaluate the safety and efficacy of AFP-derived peptides as an anti-tumor vaccine for patients with advanced HCC, and characterized induction of AFP-specific T-cell receptors (TCRs). METHODS: We performed a prospective study, of 15 patients with HCC seen at Kanazawa University Hospital in Japan from March 2010 through March 2012...
February 7, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28188039/inflammation-factors-in-hepatoblastoma-and-their-clinical-significance-as-diagnostic-and-prognostic-biomarkers
#12
Fei Guo, Qin Ru, Junjie Zhang, Shen He, Jiekai Yu, Shu Zheng, Jiaxiang Wang
PURPOSE: The aims of this study were to identify inflammation factors in hepatoblastoma tissue that correlated with different clinical characteristics, and to explore the probability as predictive biomarkers for diagnosis and prognosis. METHODS: SELDI-TOF-MS was performed to screen protein peaks that were significantly highly expressed in tumor tissue compared with adjacent liver tissue. After removing proteins larger than 30kDa, the targeted peaks were separated by solid phase extraction and tricine-SDS-PAGE...
February 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28187493/recurrence-of-hepatocellular-carcinoma-after-liver-transplantation-is-there-a-place-for-resection
#13
Elena Fernandez-Sevilla, Marc-Antoine Allard, Jasmijn Selten, Nicolas Golse, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Castaing Denis, René Adam
INTRODUCTION: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is widely considered as a terminal condition. Therefore, the role of surgery is uncertain in this case. The purpose of this study was to identify the prognostic factors of survival after post-LT HCC recurrence and evaluate the impact of surgery in this setting. PATIENTS AND METHODS: All patients transplanted for HCC between 1991 and 2013 in a single institution and who further developed a post-LT recurrence were included in this study...
February 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28187301/the-preparation-of-dual-functional-hybrid-nanoflower-and-its-application-in-the-ultrasensitive-detection-of-disease-related-biomarker
#14
Yucheng Liu, Jinyang Chen, Mingyuan Du, Xinxin Wang, Xinghu Ji, Zhike He
In this work, dual-functional streptavidin (SA)-horseradish peroxidase (HRP) hybrid nanoflowers, integrating the functions of biological recognition and signal amplification, were prepared through facile one-pot green synthesis method. The prepared SA-HRP-Cu3(PO4)2 hybrid nanoflowers loaded abundant HRP and simultaneously exhibited enhanced catalytic activity, stability, and durability compared with free enzyme, which fits greatly well with the requirement of signal tag for bioassay. Besides, due to the general SA-biotin linking interaction, the SA-HRP-Cu3(PO4)2 hybrid nanoflowers possess universal capture ability to the biotinylated antibody...
February 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28186970/high-expression-of-gfat1-predicts-unfavorable-prognosis-in-patients-with-hepatocellular-carcinoma
#15
Lili Li, Miaomiao Shao, Peike Peng, Caiting Yang, Shushu Song, Fangfang Duan, Dongwei Jia, Mingming Zhang, Junjie Zhao, Ran Zhao, Weicheng Wu, Lan Wang, Can Li, Hao Wu, Jie Zhang, Xin Wu, Yuanyuan Ruan, Jianxin Gu
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. As a branch of glucose metabolism, hexosamine biosynthesis pathway (HBP) has been reported to play a critical role in the insulin resistance and progression of cancer. Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting enzyme of the HBP; nevertheless, the prognostic value of GFAT1 in HCC remains elusive. In this study, we found that high expression of GFAT1 was significantly associated with serum alpha-fetoprotein (AFP), serum alanine aminotransferase (ALT), tumor size, tumor encapsulation, T stage and TNM stage...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28186128/ultrasensitive-label-free-electrochemical-immunosensor-based-on-multifunctionalized-graphene-nanocomposites-for-the-detection-of-alpha-fetoprotein
#16
Yaoguang Wang, Yong Zhang, Dan Wu, Hongmin Ma, Xuehui Pang, Dawei Fan, Qin Wei, Bin Du
In this work, a novel label-free electrochemical immunosensor was developed for the quantitative detection of alpha fetoprotein (AFP). Multifunctionalized graphene nanocomposites (TB-Au-Fe3O4-rGO) were applied to modify the electrode to achieve the amplification of electrochemical signal. TB-Au-Fe3O4-rGO includes the advantages of graphene, ferroferric oxide nanoparticles (Fe3O4 NPs), gold nanoparticles (Au NPs) and toluidine blue (TB). As a kind of redox probe, TB can produce the electrochemical signal. Graphene owns large specific surface area, high electrical conductivity and good adsorption property to load a large number of TB...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185302/patterns-and-challenges-of-treatment-sequencing-in-patients-with-hepatocellular-carcinoma-experience-from-a-referral-center
#17
Martha M Kirstein, Nora Schweitzer, Theresa Winter, Katerina Lappas, Nathalie Graen, Isabell Kunstmann, Torsten Voigtländer, Tanja Reineke-Plaaß, Michael P Manns, Frank Lehner, Thomas Rodt, Arndt Vogel
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers. Several local and systemic therapies are available for patients with HCC depending on the stage of the disease. In clinical practice, treatment decision-making and sequencing may be very heterogeneous. METHODS: In this study, we retrospectively analyzed treatment algorithms in 2,101 patients with HCC treated from 2000 to 2015 at Hannover Medical School, Germany. RESULTS: Transarterial chemoembolization (TACE) was the most common initial treatment (n = 545; 25...
February 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28182592/transmission-behaviors-and-prevalence-of-chlamydia-and-gonorrhea-among-adult-film-performers
#18
Marjan Javanbakht, M Claire Dillavou, Robert W Rigg, Peter R Kerndt, Pamina M Gorbach
BACKGROUND: Adult film work involves multiple sex partners, unprotected intercourse and frequent oral/rectal contact. Data on sexual networks and sexual behaviors of adult film performers (AFP) are limited. METHODS: From August 2012 to May 2013, AFPs in Los Angeles, CA, seeking care at 2 clinics that provide sexually transmitted infections (STIs) testing to performers were offered urogenital, pharyngeal, and rectal chlamydia/gonorrhea testing. Participants were 18 years or older and performed in at least 1 adult film scene within the past year...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178643/elevated-serum-visfatin-levels-are-associated-with-poor-prognosis-of-hepatocellular-carcinoma
#19
Yifan Sun, Shengbo Zhu, Zhitong Wu, Yiyong Huang, Chunming Liu, Shifu Tang, Lili Wei
Visfatin is considered a pro-inflammatory adipocytokine, and it is commonly increased in obesity-related diseases. This study aimed to evaluate the levels of serum visfatin in patients with hepatocellular carcinoma (HCC) and its diagnostic and predictive value in detecting HCC. Fasting serum levels of visfatin of 135 HCC patients, 115 chronic hepatitis B (CHB) patients, 129 liver cirrhosis (LC) patients, and 149 healthy controls were determined via enzyme-linked immunosorbent assay. Meanwhile, serum alpha fetal protein (AFP) and interleukin-6 (IL-6) were also assayed...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28169483/the-prognostic-significance-of-albi-albumin-bilirubin-t-score-in-patient-who-underwent-hepatic-resection-for-hepatocellular-carcinoma
#20
Norifumi Harimoto, Tomoharu Yoshizumi, Kazuhito Sakata, Akihisa Nagatsu, Takashi Motomura, Shinji Itoh, Noboru Harada, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: In recent years, the establishment of new staging systems for hepatocellular carcinoma (HCC) has been reported worldwide. Albumin-bilirubin (ALBI) with TNM stage of Liver Cancer Study Group of Japan was called as ALBI-T score. STUDY DESIGN: Patient data were retrospectively collected for 357 consecutive patients who had undergone hepatic resection for HCC with curative intent between January 2004 and December 2015. The overall survival and recurrence-free survival were compared by the Kaplan-Meier method, by different staging system: the Japan integrated staging (JIS), modified JIS and ALBI-T...
February 7, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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