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https://www.readbyqxmd.com/read/29145693/early-erythropoiesis-stimulating-agents-in-preterm-or-low-birth-weight-infants
#1
REVIEW
Arne Ohlsson, Sanjay M Aher
BACKGROUND: Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising enterocolitis (NEC). Darbepoetin (Darbe) and EPO are currently available ESAs. OBJECTIVES: To assess the effectiveness and safety of ESAs (erythropoietin (EPO) and/or Darbe) initiated early (before eight days after birth) compared with placebo or no intervention in reducing red blood cell (RBC) transfusions, adverse neurological outcomes, and feeding intolerance including necrotising enterocolitis (NEC) in preterm and/or low birth weight infants...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29125714/prognostic-awareness-and-communication-preferences-among-caregivers-of-patients-with-malignant-glioma
#2
A J Applebaum, K Buda, M Kryza-Lacombe, J B Buthorn, R Walker, K M Shaffer, T A D'Agostino, E L Diamond
OBJECTIVE: Malignant glioma is a devastating neuro-oncologic disease with almost invariably poor prognosis, yet many families facing malignant glioma have poor prognostic awareness (PA), or the awareness of the patient's incurable disease and shortened life-expectancy. Accurate PA is associated with favorable medical outcomes at the end-of-life for patients and psychosocial outcomes for informal caregivers (ICs) through bereavement. To date, however, no study has specifically examined PA among MG ICs and the information they receive that shapes their awareness...
November 10, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29125266/decision-making-in-very-severe-traumatic-brain-injury-glasgow-coma-scale-3-5-a-literature-review-of-acute-neurosurgical-management-of-the-most-severely-threatened-brain-trauma-patients
#3
Jeroen van Dijck, Florence Reith, Inge van Erp, Thomas van Essen, Andrew Maas, Wilco C Peul, Godard de Ruiter
BACKGROUND: Patients presenting with an early GCS score of 3-5 after blunt or penetrating skull-brain assaults are categorized as having sustained a very severe Traumatic Brain Injury (vs-TBI). This category is often overlooked in literature. Impact on patients and families lives however is huge and the question "whether to surgically treat or not" frequently poses a dilemma to treating physicians. Little is known about mortality and outcome, compared to what is known for the group of severe TBI patients (s-TBI) (GCS 3- 8)...
November 10, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29124391/implementing-a-digital-real-time-hydrocephalus-and-shunt-registry-to-evaluate-contemporary-pattern-of-care-and-surgical-outcome-in-pediatric-hydrocephalus
#4
Hans Christoph Bock, Maximilian Kanzler, Ulrich-Wilhelm Thomale, Hans Christoph Ludwig
OBJECTIVE: Treatment monitoring and outcome evaluation in pediatric hydrocephalus require gapless documentation regarding surgical and clinical follow-up data beginning from day 1 of treatment in order to apply high quality of care. Endoscopic procedures, shunt insertion and revision surgeries, and individual modifications of valve hardware or pressure settings during follow-up as well as established outcome measurements are highly relevant for complete illustration of the patient's hydrocephalus histories...
November 9, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29121852/an-informatics-approach-to-interprofessional-management-of-low-back-pain-a-feasibility-study-using-the-omaha-system
#5
Robin R Austin, Karen A Monsen, Craig Schulz
BACKGROUND: Low back pain (LBP) is a complex health care issue that often involves multiple providers across various care settings. Health information technology (HIT) holds promise to improve care delivery by providing infrastructure for communication, clinical documentation, and management of patient data. Standardized terminology is essential for interoperability and enables evaluation of clinical data generated by documentation in an electronic health record (EHR). OBJECTIVE: The purpose of this study was to demonstrate the feasibility of mapping evidence-based practice for conservative management of low back pain to the Omaha System and foster inter-professional communication and collaboration among diverse practitioners and patients...
October 6, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29120861/preventing-relapse-to-smoking-with-transcranial-magnetic-stimulation-feasibility-and-potential-efficacy
#6
Christine E Sheffer, Warren K Bickel, Thomas H Brandon, Christopher T Franck, Darwin Deen, Luana Panissidi, Syed Amir Abdali, Jami C Pittman, Sara E Lunden, Neelam Prashad, Ria Malhotra, Antonio Mantovani
Many smokers attempt to quit every year, but 90% relapse within 12 months. Converging evidence suggests relapse is associated with insufficient activation of the prefrontal cortex. Delay discounting rate reflects relative activity in brain regions associated with relapse. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (LDLPFC) increases cortical excitability and reduces delay discounting rates, but little is known about feasibility, tolerability, and potential efficacy for smoking cessation...
November 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29119260/can-positive-affect-attenuate-persistent-pain-state-of-the-art-and-clinical-implications
#7
REVIEW
Marjolein M Hanssen, Madelon L Peters, Jantine J Boselie, Ann Meulders
PURPOSE OF REVIEW: Pain is an intense experience that can place a heavy burden on peoples' lives. The identification of psychosocial risk factors led to the development of effective pain treatments. However, effect sizes are modest. Accumulating evidence suggests that enhancing protective factors might also impact on (well-being despite) pain. Recent findings on positive affect (interventions) towards pain-related outcomes will be reviewed, and new avenues for treatment of persistent pain will be discussed...
November 9, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29114077/the-ubiquitin-e3-ligase-traf6-exacerbates-ischemic-stroke-by-ubiquitinating-and-activating-rac1
#8
Tao Li, Juan-Juan Qin, Xia Yang, Yan-Xiao Ji, Fangliang Guo, Wen-Lin Cheng, Xiaolin Wu, Fu-Han Gong, Ying Hong, Xue-Yong Zhu, Jun Gong, Zhihua Wang, Zan Huang, Zhi-Gang She, Hongliang Li
Stroke is one of the leading causes of morbidity and mortality worldwide. Inflammation, oxidative stress, apoptosis, and excitotoxicity contribute to neuronal death during ischemic stroke; however, the mechanisms underlying these complicated pathophysiological processes remain to be fully elucidated. Here, we found that the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) was markedly increased after cerebral ischemia/reperfusion (I/R) in mice. TRAF6 ablation in male mice decreased the infarct volume and neurological deficit scores, and decreased pro-inflammatory signaling, oxidative stress and neuronal death after cerebral I/R, whereas transgenic overexpression of TRAF6 in male mice exhibited opposite effects...
November 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29099872/a-pilot-randomized-controlled-trial-of-ekg-for-neonatal-resuscitation
#9
Anup Katheria, Kathy Arnell, Melissa Brown, Kasim Hassen, Mauricio Maldonado, Wade Rich, Neil Finer
BACKGROUND: The seventh edition of the American Academy of Pediatrics Neonatal Resuscitation Program recommends the use of a cardiac monitor in infants that need resuscitation. Previous trials have shown that EKG heart rate is available before pulse rate from a pulse oximeter. To date no trial has looked at how the availability of electrocardiogram (EKG) affects clinical interventions in the delivery room. OBJECTIVE: To determine whether the availability of an EKG heart rate value and tracing to the clinical team has an effect on physiologic measures and related interventions during the stabilization of preterm infants...
2017: PloS One
https://www.readbyqxmd.com/read/29098879/regulation-of-circulating-chromogranin-b-levels-in-heart-failure
#10
Felix M Heidrich, Carolin Melz, Mimi S Buechau, Christian Pfluecke, Silvio Quick, Uwe Speiser, David M Poitz, Antje Augstein, Tobias Ruf, Nadine K Wäßnig, Akram Youssef, Ruth H Strasser, Stephan Wiedemann
BACKGROUND: Chromogranin B (CGB) regulates B-type natriuretic peptide (BNP) production. Circulating CGB levels are elevated in heart failure (HF) animal models and HF patients, but also increase in healthy individuals in response to physical activity. Therefore, CGB seems to integrate information from myocardial stress and systemic neuro-endocrine activation. Substantial gaps remain in our understanding of CGB regulation in HF. METHODS AND RESULTS: We conducted a retrospective registry study including 372 patients...
November 3, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29098418/bilateral-carotid-cavernous-sinus-fistula-a-case-report-and-review-of-the-literature
#11
REVIEW
Gavin Docherty, Maryam Eslami, Kailun Jiang, Jason S Barton
Carotid cavernous fistula (CCF) is an abnormal vascular shunt from the carotid artery to the cavernous sinus. They are commonly classified based on hemodynamics, etiology or anatomically. Hemodynamic classification refers to whether the fistula is high or low flow. Etiology is commonly secondary to trauma or can occur spontaneously in the setting of aneurysm or medical conditions predisposing to arterial wall defects. Bilateral carotid cavernous fistulas are rare. We present a case of bilateral CCF secondary to trauma...
November 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29091053/multiscale-network-representation-of-physiological-time-series-for-early-prediction-of-sepsis
#12
Supreeth Prajwal Shashikumar, Qiao Li, Gari D Clifford, Shamim Nemati
Sepsis, a dysregulated immune-mediated host response to infection, is the leading cause of morbidity and mortality in critically ill patients. Indices of heart rate variability and complexity (such as entropy) have been proposed as surrogate markers of Neuro-immune system dysregulation with diseases such as sepsis. However, these indices only provide an average, one dimensional description of complex neuro-physiological interactions. We propose a novel multiscale network construction and analysis method for multivariate physiological time series, and demonstrate its utility for early prediction of sepsis...
November 1, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29088984/strengthening-the-role-and-functions-of-nursing-staff-in-inpatient-stroke-rehabilitation-developing-a-complex-intervention-using-the-behaviour-change-wheel
#13
Mia Ingerslev Loft, Bente Martinsen, Bente Appel Esbensen, Lone L Mathiesen, Helle K Iversen, Ingrid Poulsen
PURPOSE: Over the past two decades, attempts have been made to describe the nurse's role and functions in the inpatient stroke rehabilitation; however, the nursing contribution is neither clear nor well-defined. Previous studies have highlighted the need for research aimed at developing interventions in the neuro-nursing area. The objective of this paper was to describe the development of a nursing intervention aimed at optimising the inpatient rehabilitation of stroke patients by strengthening the role and functions of nursing staff...
2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29069871/leptomeningeal-disease-current-diagnostic-and-therapeutic-strategies
#14
REVIEW
Gautam Nayar, Tiffany Ejikeme, Pakawat Chongsathidkiet, Aladine A Elsamadicy, Kimberly L Blackwell, Jeffrey M Clarke, Shivanand P Lad, Peter E Fecci
Leptomeningeal disease has become increasingly prevalent as novel therapeutic interventions extend the survival of cancer patients. Although a majority of leptomeningeal spread occurs secondary to breast cancer, lung cancer, and melanoma, a wide variety of malignancies have been reported as primary sources. Symptoms on presentation are equally diverse, often involving a combination of neurological deficits with the possibility of obstructive hydrocephalus. Diagnosis is definitively made via cerebrospinal fluid cytology for malignant cells, but neuro-imaging with high quality T1-weighted magnetic resonance imaging can aid diagnosis and localization...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29067867/comparison-of-transcutaneous-electrical-nerve-stimulation-tens-and-functional-electrical-stimulation-fes-for-spasticity-in-spinal-cord-injury-a-pilot-randomized-cross-over-trial
#15
Anjali Sivaramakrishnan, John M Solomon, Natarajan Manikandan
OBJECTIVE: Spasticity following spinal cord injury (SCI) can impair function and affect quality of life. This study compared the effects of transcutaneous electrical nerve stimulation (TENS) and functional electrical stimulation (FES) on lower limb spasticity in patients with SCI. DESIGN: Double blind randomized crossover design. SETTING: Neuro-rehabilitation unit, Manipal University, India. PARTICIPANTS: Ten participants (age: 39 ± 13...
October 25, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29060073/research-on-the-synchronous-detection-of-neuronal-signals-under-a-nerve-stimulation-system-control
#16
Yu Zhang, Shengwei Xu, Lili Yang, Guihua Xiao, Song Zhang, Fei Gao, Ziyue Li, Mixia Wang, Yilin Song, Xinxia Cai
Deep brain stimulation (DBS) provides a recognized research intervention for neurological disease currently. However, there is a lack of traditional electrical stimulator to observe neuronal firing activity synchronously. The aim of the present study was to realize concurrent detection of neuronal signals better under a nerve stimulation system control. Herein, we designed an integrated software, which could control not only neuro-stimulator but also detection instrument at the same time. Moreover, the actual stimulation signals applied to the experiment object could be collected back to data acquisition card and in consistent with the electrophysiological signals...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054956/indirect-carotid-cavernous-fistula-mimicking-ocular-myasthenia
#17
Lakshmi Leishangthem, Sudhakar Reddy Satti
71-year-old woman with progressive left-sided, monocular diplopia and ptosis. Her symptoms mimicked ocular myasthenia, but she had an indirect carotid cavernous fistula (CCF). She was diagnosed with monocular myasthenia gravis (negative acetylcholinesterase antibody) after a positive ice test and started on Mestinon and underwent a thymectomy complicated by a brachial plexus injury. Months later, she developed left-sided proptosis and ocular bruit. She was urgently referred to neuro-interventional surgery and was diagnosed with an indirect high-flow left CCF, which was treated with Onyx liquid and platinum coil embolisation...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29052102/changes-in-cerebellar-functional-connectivity-and-autonomic-regulation-in-cancer-patients-treated-with-the-neuro-emotional-technique-for-traumatic-stress-symptoms
#18
Daniel A Monti, Anna Tobia, Marie Stoner, Nancy Wintering, Michael Matthews, Chris J Conklin, Feroze B Mohamed, Inna Chervoneva, Andrew B Newberg
PURPOSE: A growing number of research studies have implicated the cerebellum in emotional processing and regulation, especially with regard to negative emotional memories. However, there currently are no studies showing functional changes in the cerebellum as a result of treatment for traumatic stress symptoms. The Neuro Emotional Technique (NET) is an intervention designed to help improve symptoms related to traumatic stress using an integrative approach that combines emotional, cognitive, and motor processing, with a particular focus on autonomic nervous system regulation...
October 19, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29032220/electodiagnostic-and-advanced-neuro-imaging-characterization-for-successful-treatment-of-a-spinal-extradural-arachnoid-cyst
#19
Tomoko Tanaka, Raja S Boddepalli, Douglas C Miller, Zongxian Cao, Vivek Sindhwani, Joan R Coates, Raghav Govindarajan, N Scott Litofsky
BACKGROUND: Spinal extradural arachnoid cysts (SEAC) are relatively uncommon. However, several large cysts have presented with spinal cord compression requiring surgical intervention. CASE DESCRIPTION: We report a patient with progressively enlarging SEAC causing worsening right S1 radiculopathy and gastrocnemius muscle atrophy. Electromyography (EMG) and nerve conduction studies (NCS) revealed an S1 motor radiculopathy. Serial magnetic resonance imaging (MRI) findings confirmed enlargement of the small cyst originating from the sacral thecal sac on the right while two smaller cyst on the left remained stable...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29018076/protocol-for-a-prospective-interventional-trial-to-develop-a-diagnostic-index-test-for-stroke-as-a-cause-of-vertigo-dizziness-and-imbalance-in-the-emergency-room-emvert-study
#20
Ken Möhwald, Stanislavs Bardins, Hans-Helge Müller, Klaus Jahn, Andreas Zwergal
INTRODUCTION: Identifying stroke as a cause of acute vertigo, dizziness and imbalance in the emergency room is still a clinical challenge. Many patients are admitted to stroke units, but only a minority will have strokes. This imposes a heavy financial burden on the healthcare system. The aim of this study is to develop a diagnostic index test to identify patients with a high risk of having a stroke as the cause of acute vertigo and imbalance. METHODS AND ANALYSIS: Patients with acute onset of vertigo, dizziness, postural imbalance or double vision within the last 24 hours lasting for at least 10 min are eligible to be included in the study...
October 10, 2017: BMJ Open
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