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GnRH Antagonist

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https://www.readbyqxmd.com/read/29040622/neurokinin-b-regulates-gonadotropin-secretion-ovarian-follicle-growth-and-the-timing-of-ovulation-in-healthy-women
#1
Karolina Skorupskaite, Jyothis T George, Johannes D Veldhuis, Richard A Anderson
Context: Neurokinin B (NKB) is obligate for human puberty, but its role in adult female gonadotropin secretion and ovarian follicle growth is unknown. Objective: To investigate antagonism of NKB on pulsatile GnRH/LH secretion and ovarian follicle development in normal women. Design: Open investigation of the effects of a neurokinin-3 receptor antagonist (NK3Ra) vs no treatment control cycle. Setting: Clinical Research Facility...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29040589/corifollitropin-alfa-followed-by-highly-purified-hmg-versus-recombinant-fsh-in-young-poor-ovarian-responders-a-multicentre-randomized-controlled-clinical-trial
#2
Panagiotis Drakopoulos, Thi Ngoc Lan Vuong, Ngoc Anh Vu Ho, Alberto Vaiarelli, Manh Tuong Ho, Christophe Blockeel, Michel Camus, Anh Tuan Lam, Arne van de Vijver, Peter Humaidan, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: Does administration of corifollitropin alfa followed by highly purified (hp) HMG result in higher ongoing pregnancy rates compared with daily recombinant FSH (rFSH) in young poor responders? SUMMARY ANSWER: Corifollitropin alfa followed by hp-HMG does not increase ongoing pregnancy rates compared with rFSH in young poor responders, although more supernumerary cryopreserved embryos were obtained with corifollitropin alfa and hp-HMG. WHAT IS KNOWN ALREADY: Poor ovarian response remains one of the main therapeutic challenges in women undergoing ovarian stimulation, given that very low live birth rates of 6% have been reported in this particular group of infertile patients...
September 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29037085/luteal-phase-serum-progesterone-levels-after-gnrh-agonist-trigger-how-low-is-still-high-enough-for-an-ongoing-pregnancy
#3
B Lawrenz, S Samir, L Melado, F Ruiz, H M Fatemi
In the past years, individualization of assisted reproductive technique (ART)-treatment is increasingly common to customize the treatment protocol to the patient's specific conditions. The use of GnRH-agonist for final oocyte maturation in a gonadotropin-releasing hormone (GnRH)-antagonist protocol is the best approach to reduce the risk for ovarian hyperstimulation in high responder patients. However, due to severe luteolysis, the reproductive outcome with this approach in combination with the use of vaginal progesterone as luteal phase support, was poor...
October 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29020783/-corifollitropin-alfa-in-women-stimulated-for-the-first-time-in-in%C3%A2-vitro-fertilization-programme
#4
N Vraná-Mardešićová, J Vobořil, L Melicharová, L Jelínková, Š Vilímová, T Mardešić
OBJECTIVES: To compare results after stimulation with corifollitropin alfa (Elonva) in unselected group of women entering for the first time in in vitro fertilization programme (IVF) with results from Phase III randomized trials with selected groups of women. DESIGN: Prospective study. SETTING: Sanatorium Pronatal, Praha. METHODS: 40 unselected women with adequat ovarian reserve entering for the first time in IVF programme were stimulated with corifollitropin alfa and GnRH antagonists...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29019791/the-influence-of-dopaminergic-system-inhibition-on-biosynthesis-of-gonadotrophin-releasing-hormone-gnrh-and-gnrh-receptor-in-anoestrous-sheep-hierarchical-role-of-kisspeptin-and-rfamide-related-peptide-3-rfrp-3
#5
M Ciechanowska, M Łapot, E Paruszewska, W Radawiec, F Przekop
This study aimed to explain how prolonged inhibition of central dopaminergic activity affects the cellular processes governing gonadotrophin-releasing hormone (GnRH) and LH secretion in anoestrous sheep. For this purpose, the study included two experimental approaches: first, we investigated the effect of infusion of sulpiride, a dopaminergic D2 receptor antagonist (D2R), on GnRH and GnRH receptor (GnRHR) biosynthesis in the hypothalamus and on GnRHR in the anterior pituitary using an immunoassay. This analysis was supplemented by analysis of plasma LH levels by radioimmunoassay...
October 12, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28989921/gonadotropin-releasing-hormone-antagonist-administration-for-treatment-of-early-type-severe-ovarian-hyperstimulation-syndrome-a-case-series
#6
Dayong Lee, Se Jeong Kim, Yeon Hee Hong, Seul Ki Kim, Byung Chul Jee
OBJECTIVE: To report an efficacy of gonadotropin releasing hormone (GnRH) antagonist administration after freezing of all embryos for treatment of early type ovarian hyperstimulation syndrome (OHSS). METHODS: In 10 women who developed fulminant early type OHSS after freezing of all embryos, GnRH antagonist (cetrorelix 0.25 mg per day) was started at the time of hospitalization and continued for 2 to 4 days. Fluid therapy and drainage of ascites was performed as usual...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28977601/kisspeptin-and-neurokinin-b-signaling-network-underlies-the-pubertal-increase-in-gnrh-release-in-female-rhesus-monkeys
#7
James P Garcia, Kathryn A Guerriero, Kim L Keen, Brian P Kenealy, Stephanie B Seminara, Ei Terasawa
Loss-of-function or inactivating mutations in the genes coding for kisspeptin and its receptor (KISS1R) or neurokinin B (NKB) and the NKB receptor (NK3R) in humans result in a delay in or the absence of puberty. However, precise mechanisms of kisspeptin and NKB signaling in the regulation of the pubertal increase in gonadotropin-releasing hormone (GnRH) release in primates are unknown. In this study, we conducted a series of experiments infusing agonists and antagonists of kisspeptin and NKB into the stalk-median eminence, where GnRH, kisspeptin, and NKB neuroterminal fibers are concentrated, and measuring GnRH release in prepubertal and pubertal female rhesus monkeys...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28971491/plumbagin-improves-the-efficacy-of-androgen-deprivation-therapy-in-prostate-cancer-a-pre-clinical-study
#8
Parisa Abedinpour, Véronique T Baron, Adrian Chrastina, Gaelle Rondeau, Jennifer Pelayo, John Welsh, Per Borgström
BACKGROUND: Plumbagin is a candidate drug for the treatment of prostate cancer. Previous observations indicated that it may improve the efficacy of androgen deprivation therapy (ADT). This study evaluates the effectiveness of treatment with combinations of plumbagin and alternative strategies for ADT in mouse models of prostate cancer to support its clinical use. METHODS: Plumbagin was administered per oral in a new sesame oil formulation. Standard toxicology studies were performed in rats...
October 2, 2017: Prostate
https://www.readbyqxmd.com/read/28970135/pregnancy-outcomes-after-controlled-ovarian-hyperstimulation-in-women-with-endometriosis-associated-infertility-gnrh-agonist-versus-gnrh-antagonist
#9
Kamila Kolanska, Jonathan Cohen, Sofiane Bendifallah, Lise Selleret, Jean-Marie Antoine, Nathalie Chabbert-Buffet, Emile Darai, Emmanuelle Mathieu d'Argent
BACKGROUND OR OBJECTIVE: Endometriosis is common in women referred for infertility. In vitro fertilization provides good results but the choice of the best controlled ovarian hyperstimulation protocol remains a subject of debate. The objective of this retrospective study was to compare pregnancy outcomes in women with endometriosis-associated infertility after COH with a long agonist protocol or a six-week oral contraception-antagonist protocol. MATERIAL AND METHODS: Retrospective analysis of a prospective database identified 284 COH cycles - 165 with GnRH-agonist protocol (GnRH-agonist group) and 119 with GnRH-antagonist protocol (GnRH-antagonist group) - in 218 women, with endometriosis from January 2013 to October 2015...
September 29, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28969562/ovarian-stimulation-in-poor-responders-have-we-made-progress
#10
Robert Roman, Naiha Mussarat, Laura Detti
BACKGROUND: Poor ovarian responders (POR) pose a challenge to a physicians' ability to choose a stimulation protocol that maximizes the number of oocytes harvested and their chances of conception with multiple protocols aimed at improving pregnancy rates in this poor prognosis population. The Bologna criteria standardized the diagnosis of POR and allows for a more homogenous patient population in clinical trials. METHODS: A structured review of the literature, which encompasses research on Bologna-defined POR, identified several proposed protocols to optimize pregnancy rates in poor responders...
October 2, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28965551/modified-natural-cycle-in-in%C3%A2-vitro-fertilization
#11
REVIEW
Jacqueline R Ho, Richard J Paulson
The first live birth after IVF was achieved in a purely natural cycle. Because early attempts at IVF were associated with low efficiency, ovarian stimulation was added to achieve a greater margin for error in oocyte retrieval, fertilization, and thus, overall pregnancy success. As technology improved, the intuitive appeal of the natural cycle led investigators to once again attempt IVF without antecedent gonadotropin stimulation. Triggering of ovulation with hCG was added to allow for accurate scheduling of oocyte retrieval and thus increased oocyte yield...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28965278/the-value-of-delaying-hcg-administration-to-enable-maturation-of-medium-sized-follicles-in-patients-undergoing-superovulation-for-ivf-icsi
#12
Awoniyi O Awonuga, Karen Wheeler, Mili Thakur, Roohi Jeelani, Michael P Diamond, Elizabeth E Puscheck
PURPOSE: The purpose of the study is to determine whether continued stimulation of mature follicles to allow "catch up" growth of medium-sized follicles in assisted reproductive technology compromises the clinical pregnancy (CPR) and live birth (LBR) rates in IVF/ICSI cycles. METHODS: This retrospective cohort study reviewed 200 first IVF ± ICSI cycles out of a total of 340 cycles with complete data. Women underwent stimulation protocols with gonadotropins (Gn) and GnRH antagonist...
September 30, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28964731/time-and-dose-related-effects-of-a-gonadotropin-releasing-hormone-agonist-and-dopamine-antagonist-on-reproduction-in-the-northern-leopard-frog-lithobates-pipiens
#13
Maria Vu, Bradley Weiler, Vance L Trudeau
Gonadotropin-releasing hormone (GnRH) stimulates luteinizing hormone release to control ovulation and spermiation in vertebrates. Dopamine (DA) has a clear inhibitory role in the control of reproduction in numerous teleosts, and emerging evidence suggests that similar mechanisms may exist in amphibians. The interactions between GnRH and DA on spawning success and pituitary gene expression in the Northern leopard frog (Lithobates pipiens) were therefore investigated. Frogs were injected during the natural breeding season with a GnRH agonist [GnRH-A; (Des-Gly(10), D-Ala(6), Pro-NHEt(9))-LHRH; 0...
December 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28960452/fertility-treatment-outcomes-after-follicle-tracking-with-standard-2-dimensional-sonography-versus-3-dimensional-sonography-based-automated-volume-count-prospective-study
#14
Avital Wertheimer, Ran Nagar, Galia Oron, Israel Meizner, Benjamin Fisch, Avi Ben-Haroush
OBJECTIVES: The use of sonography-based Automated Volume Count (SonoAVC; GE Healthcare, Kretz, Zipf, Austria) leads to substantially lower intraobserver and interobserver variability with a considerable advantage in time gain for both the physician and patient. It offers the possibility of continuous training and standardization of follicular monitoring. Manual and automated follicular measurements during in vitro fertilization (IVF) are reported to be comparable during gonadotropin-releasing hormone (GnRH) agonist treatment...
September 29, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28960413/an-efficient-synthesis-of-deuterium-labeled-degarelix-acetate-a-third-generation-gonadotropin-releasing-hormone-receptor-antagonist
#15
Yu Huang, Jingshun Chen, Baomin Liu, Hua Wang, Lu Zhang, Zhengbang Chen, Yinsheng Zhang
Degarelix acetate, a third-generation gonadotropin-releasing hormone (GnRH) receptor antagonist, shows great potential in the treatment of many androgen-related diseases. To support clinical studies of degarelix acetate, deuterium-labeled degarelix is highly desired for use as an internal standard. Using D2 O/D3 PO4 as a deuterium source, 2-amino-3-(naphthalen-2-yl)propanoic acid was converted to deuterated degarelix acetate in 13 steps and in 14% overall yield.
September 29, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28957685/dual-trigger-of-final-oocyte-maturation-with-a-combination-of-gnrh-agonist-and-hcg-versus-a-hcg-alone-trigger-in-gnrh-antagonist-cycle-for-in-vitro-fertilization-a-systematic-review-and-meta-analysis
#16
REVIEW
Nan Ding, Xingchen Liu, Qiliang Jian, Zhongzhen Liang, Fang Wang
OBJECTIVE: Increasing evidence indicates that a dual trigger (a gonadotrophin-releasing hormone agonist [GnRH-a] with a human chorionic gonadotrophin [hCG] trigger) is the best choice for final oocyte maturation in the GnRH antagonist (GnRH-ant) cycle. However, this conclusion remains controversial. Therefore, we performed this meta-analysis to systematically evaluate the efficacy of a GnRH-a combined with a standard hCG trigger in comparison with hCG alone for final oocyte maturation in the GnRH-ant cycle for in vitro fertilization...
September 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28942696/gnrh-antagonist-does-not-prevent-premature-luteinization-and-ovulation-in-stimulated-cycles-with-gonadotropins-for-ivf-two-case-reports
#17
Pieraldo Inaudi, Valeria Barra, Francesca Letizia Vellucci, Cristina Regini, Stefano Luisi
The use of GnRH antagonists (GnRHant) is increasing in the ovarian stimulation protocol. Among several other benefits, GnRHant should prevent a premature luteinization and premature ovulation, the first described either as a 'reassuringly rare event' or 'frequent event', while the second as occurring more frequently in women with decreased ovarian reserve, advanced age and poor ovarian response. Two cases of associated premature luteinization and premature ovulation, during treatment with gonadotropins and GnRHant in IVF cycles, are here reported...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28934084/outcome-of-icsi-with-motile-testicular-spermatozoa-obtained-through-microscopically-assisted-testicular-sperm-extraction-in-relation-to-the-ovarian-response
#18
E Erdem, M Karacan, A Usta, A Arvas, Z Cebi, T Camlibel
INTRODUCTION: To determine the relationship between AFC, basal FSH level, woman's age, the number of oocytes retrieved and the outcome of ICSI with testicular spermatozoa obtained with microscopically assisted testicular sperm extraction. MATERIAL AND METHODS: In this retrospective cohort study, a total of 340 couples who underwent ICSI treatment with testicular sperm were enrolled. Women aged?40years and the first cycles of couples were included. ICSI was performed with motile testicular spermatozoa obtained from 89 men with obstructive azoospermia and 251 men with nonobstructive azoospermia...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28911172/androgens-mediate-sex-dependent-gonadotropin-expression-during-late-prenatal-development-in-the-mouse
#19
Michael J Kreisman, Christopher I Song, Kathleen Yip, Bryony V Natale, David R Natale, Kellie M Breen
Central organization of the hypothalamic-pituitary-gonadal axis is initiated during fetal life. At this critical time, gonadal hormones mediate sex-specific development of the hypothalamic-pituitary axis, which then dictates reproductive physiology and behavior in adulthood. Although studies have investigated the effects of prenatal androgens on central factors influencing gonadotropin-releasing hormone (GnRH) release, the impact of fetal androgens on gonadotrope function has been overlooked. In the current study, we demonstrated that gonadotropin gene expression and protein production were robustly elevated in female mice compared with males during late fetal development and that this sex difference was dependent on fetal androgens...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28903472/gnrh-antagonist-versus-long-agonist-protocols-in-ivf-a-systematic-review-and-meta-analysis-accounting-for-patient-type
#20
C B Lambalk, F R Banga, J A Huirne, M Toftager, A Pinborg, R Homburg, F van der Veen, M van Wely
BACKGROUND: Most reviews of IVF ovarian stimulation protocols have insufficiently accounted for various patient populations, such as ovulatory women, women with polycystic ovary syndrome (PCOS) or women with poor ovarian response, and have included studies in which the agonist or antagonist was not the only variable between the compared study arms. OBJECTIVE AND RATIONALE: The aim of the current study was to compare GnRH antagonist protocols versus standard long agonist protocols in couples undergoing IVF or ICSI, while accounting for various patient populations and treatment schedules...
September 1, 2017: Human Reproduction Update
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