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https://www.readbyqxmd.com/read/29448255/intrathecal-administration-of-cxcl1-enhances-potassium-currents-in-microglial-cells
#1
Alexandru-Florian Deftu, Violeta Ristoiu, Marc Rene Suter
The functioning of microglial cells inside the central nervous system depends on their ion channels expression. Microglia are capable of synthesizing different cytokines and chemokines, including CXCL1, and responding to their action via specific receptors. In this study, we explore the effect of intrathecal injection of CXCL1 on potassium currents, expressed in CX3CR1-Green Fluorescent Protein labeled microglia in transgenic mice. The results showed that CXCL1 hyperpolarized the cells by enhancing inward rectifying potassium currents and increasing the membrane area, suggesting an activating effect on microglia...
February 15, 2018: Pharmacology
https://www.readbyqxmd.com/read/29446734/cx3cl1-cx3cr1-axis-as-the-therapeutic-potential-in-renal-diseases-friend-or-foe
#2
Quan Zhuang, Ke Cheng, Yingzi Ming
The fractalkine receptor chemokine (C-X3-C motif) receptor 1 (CX3CR1) and its highly selective ligand CX3CL1 mediate chemotaxis and adhesion of immune cells, which are involved in the pathogenesis and progression of numerous inflammatory disorders and malignancies. The CX3CL1/CX3CR1 axis has recently drawn attention as a potential therapeutic target because it is involved in the ontogeny, homeostatic migration, or colonization of renal phagocytes. We performed a Medline/PubMed search to detect recently published studies that explored the relationship between the CX3CL1/CX3CR1 axis and renal diseases and disorders, including diabetic nephropathy, renal allograft rejection, infectious renal diseases, IgA nephropathy, fibrotic kidney disease, lupus nephritis and glomerulonephritis, acute kidney injury and renal carcinoma...
February 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29443058/two-photon-intravital-imaging-of-leukocytes-during-the-immune-response-in-lipopolysaccharide-treated-mouse-liver
#3
Sang A Park, Young Ho Choe, Sung Hwan Lee, Young-Min Hyun
Sepsis is a type of severe infection that can cause organ failure and tissue damage. Although the mortality and morbidity rates associated with sepsis are extremely high, no direct treatment or organ-related mechanism has been examined in detail in real time. The liver is the key organ that manages toxins and infections in the human body. Herein, we aimed to perform intravital imaging of mouse liver after induction of endotoxemia in order to track the motility of immune cells, such as neutrophils and liver capsular macrophages (LCMs)...
February 6, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29434374/reactive-oxygen-species-regulate-axonal-regeneration-through-the-release-of-exosomal-nadph-oxidase-2-complexes-into-injured-axons
#4
Arnau Hervera, Francesco De Virgiliis, Ilaria Palmisano, Luming Zhou, Elena Tantardini, Guiping Kong, Thomas Hutson, Matt C Danzi, Rotem Ben-Tov Perry, Celio X C Santos, Alexander N Kapustin, Roland A Fleck, José Antonio Del Río, Thomas Carroll, Vance Lemmon, John L Bixby, Ajay M Shah, Mike Fainzilber, Simone Di Giovanni
Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by the inflammatory response after injury. Here we show that ROS, which promote axonal dieback and degeneration after injury, are also required for axonal regeneration and functional recovery after spinal injury. We find that ROS production in the injured sciatic nerve and dorsal root ganglia requires CX3CR1-dependent recruitment of inflammatory cells. Next, exosomes containing functional NADPH oxidase 2 complexes are released from macrophages and incorporated into injured axons via endocytosis...
February 12, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29433150/cx3cr1-cx3cl1-axis-mediates-platelet-leukocyte-adhesion-to-arterial-endothelium-in-younger-patients-with-a-history-of-idiopathic-deep-vein-thrombosis
#5
Elena Furio, Maria Jose García-Fuster, Josep Redon, Patrice Marques, Rebeca Ortega, Maria Jesus Sanz, Laura Piqueras
Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) with a history of idiopathic DVT and without known cardiovascular risk factors and 23 aged-matched control subjects (age: 34 ± 7.8 years). Flow cytometry was used to evaluate peripheral markers of platelet activation, leukocyte immunophenotypes and CX3CR1/CX3CL1 expression in both groups...
February 12, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29431866/monocyte-subsets-and-their-phenotypes-during-treatment-with-bcr-abl1-tyrosine-kinase-inhibitors-for-philadelphia-chromosome-positive-leukemia
#6
Takaaki Konuma, Chisato Kohara, Eri Watanabe, Motoko Mizukami, Etsuko Nagai, Susumu Tanoue, Masamichi Isobe, Koji Jimbo, Seiko Kato, Nobuhiro Ohno, Satoshi Takahashi, Arinobu Tojo
BCR-ABL1 tyrosine kinase inhibitors (TKIs) are effective agents in the treatment of Philadelphia chromosome-positive leukemia. However, vascular events have developed in some patients receiving each TKI. The perturbation of circulating monocyte subsets and their expressions of chemokine and scavenger receptors are associated with the development of cardiovascular events. Here, we examined the subsets of circulating monocytes and their phenotypes in 51 patients treated with imatinib, nilotinib, and dasatinib, and 11 healthy subjects in our institute...
February 12, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29415879/the-homozygous-cx3cr1-m280-mutation-impairs-human-monocyte-survival
#7
Amanda L Collar, Muthulekha Swamydas, Morgan O'Hayre, Md Sanaullah Sajib, Kevin W Hoffman, Satya P Singh, Ahmad Mourad, Melissa D Johnson, Elise Mn Ferre, Joshua M Farber, Jean K Lim, Constantinos M Mikelis, J Silvio Gutkind, Michail S Lionakis
Several reports have demonstrated that mouse Cx3cr1 signaling promotes monocyte/macrophage survival. In agreement, we previously found that, in a mouse model of systemic candidiasis, genetic deficiency of Cx3cr1 resulted in increased mortality and impaired tissue fungal clearance associated with decreased macrophage survival. We translated this finding by showing that the dysfunctional CX3CR1 variant CX3CR1-M280 was associated with increased risk and worse outcome of human systemic candidiasis. However, the impact of this mutation on human monocyte/macrophage survival is poorly understood...
February 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29401617/rev-erbs-agonism-suppresses-osteoclastogenesis-and-prevents-ovariectomy-induced-bone-loss-partially-via-fabp4-upregulation
#8
Chao Song, Peng Tan, Zheng Zhang, Wei Wu, Yonghui Dong, Liming Zhao, Huiyong Liu, Hanfeng Guan, Feng Li
REV-ERBs (REV-ERBα and REV-ERBβ) are transcription repressors and circadian regulators. Previous investigations have shown that REV-ERBs repress the expression of target genes, including MMP9 and CX3CR1, in macrophages. Because MMP9 and CX3CR1 reportedly participate in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis, we inferred that REV-ERBs might play a role in osteoclastogenesis. In the present study, we found that the REV-ERBα level decreased significantly during RANKL-induced osteoclast differentiation from primary bone marrow-derived macrophages (BMMs)...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29386201/cd301b-mgl2-mononuclear-phagocytes-orchestrate-autoimmune-cardiac-valve-inflammation-and-fibrosis
#9
Lee A Meier, Jennifer L Auger, Brianna J Engelson, Hannah M Cowan, Elise R Breed, Mayra I Gonzalez-Torres, Joshua D Boyer, Mayank Verma, Aubyn Marath, Bryce A Binstadt
Background -Valvular heart disease (VHD) is common and affects the mitral valve (MV) most frequently. Despite the prevalence of mitral valve disease (MVD), the cellular and molecular pathways that initiate and perpetuate it are not well understood. Methods -K/B.g7 T cell receptor (TCR) transgenic mice spontaneously develop systemic autoantibody-associated autoimmunity, leading to fully-penetrant fibro-inflammatory MVD and arthritis. We used multiparameter flow cytometry, intracellular cytokine staining, and immunofluorescent staining to characterize the cells in inflamed K/B...
January 31, 2018: Circulation
https://www.readbyqxmd.com/read/29382353/laquinimod-attenuates-inflammation-by-modulating-macrophage-functions-in-traumatic-brain-injury-mouse-model
#10
Atsuko Katsumoto, Aline S Miranda, Oleg Butovsky, Antônio L Teixeira, Richard M Ransohoff, Bruce T Lamb
BACKGROUND: Traumatic brain injury (TBI) is a critical public health and socio-economic problem worldwide. A growing body of evidence supports the involvement of inflammatory events in TBI. It has been reported that resident microglia and infiltrating monocytes promote an inflammatory reaction that leads to neuronal death and eventually behavioral and cognitive impairment. Currently, there is no effective treatment for TBI and the development of new therapeutic strategies is a scientific goal of highest priority...
January 30, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29368003/the-role-of-angiotensin-ii-at1-receptor-signaling-in-regulating-retinal-microglial-activation
#11
Joanna A Phipps, Kirstan A Vessey, Alice Brandli, Nupur Nag, Mai X Tran, Andrew I Jobling, Erica L Fletcher
Purpose: This study explored whether the proangiogenic factor Angiotensin II (AngII) had a direct effect on the activation state of microglia via the Angiotensin type 1 receptor (AT1-R). Methods: Microglial dynamic activity was investigated in live retinal flatmounts from adult Cx3Cr1+/GFP mice under control, AngII (5 μM) or AngII (5 μM) + candesartan (0.227 μM) conditions. The effects of intravitreal administration of AngII (10 mM) were also investigated at 24 hours, with retinae processed for immunocytochemistry, flow cytometry, or inflammatory quantitative PCR arrays...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29365775/cx3cr1-cd11c-leukocytes-control-the-repair-of-arterial-endothelium
#12
Per Fogelstrand, Ulf Yrlid, Maricris Holm, Malin Lindbom, Malin Levin, Jan Borén
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365463/influence-of-short-term-intensive-atorvastatin-therapy-on-lymphocyte-and-monocyte-subpopulations-and-ccr2-ccr5-cx3cr1-and-tlr4-expression-in-blood-of-patients-with-stable-angina
#13
Anastasiia Filatova, Galina Kuznetsova, Alexandra Shchinova, Anna Osokina, Alexandra Potekhina, Nataliya Ruleva, Nataliya Radukhina, Elena Noeva, Sergey Provatorov, Tatiana Arefieva, Tamila Matrynyuk
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29361745/microglia-and-aging-the-role-of-the-trem2-dap12-and-cx3cl1-cx3cr1-axes
#14
REVIEW
Carmen Mecca, Ileana Giambanco, Rosario Donato, Cataldo Arcuri
Depending on the species, microglial cells represent 5-20% of glial cells in the adult brain. As the innate immune effector of the brain, microglia are involved in several functions: regulation of inflammation, synaptic connectivity, programmed cell death, wiring and circuitry formation, phagocytosis of cell debris, and synaptic pruning and sculpting of postnatal neural circuits. Moreover, microglia contribute to some neurodevelopmental disorders such as Nasu-Hakola disease (NHD), and to aged-associated neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and others...
January 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29360187/altered-proportion-of-ccr2-and-cx3cr1-circulating-monocytes-in-neovascular-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy
#15
Yousif Subhi, Marie Krogh Nielsen, Christopher Rue Molbech, Torben Lykke Sørensen
BACKGROUND: We investigated the expression of chemokine receptors CCR2 and CX3CR1 on circulating monocyte subsets in patients with neovascular age-related macular degeneration and patients with polypoidal choroidal vasculopathy. METHODS: We recruited patients with neovascular age-related macular degeneration, patients with polypoidal choroidal vasculopathy, and age-matched healthy controls for this prospective case-control study. All participants underwent comprehensive clinical examination and imaging...
January 23, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29356931/cx3cl1-cx3cr1-axis-contributes-to-angiotensin-ii-induced-vascular-smooth-muscle-cell-proliferation-and-inflammatory-cytokine-production
#16
Chengsheng Li, Jin He, Xiaoyi Zhong, Hua Gan, Yunfeng Xia
Angiotensin II (Ang II) dysregulation has been determined in many diseases. The CX3CL1/CX3CR1 axis, which has a key role in cardiovascular diseases, is involved in the proliferation and inflammatory cytokine production of vascular smooth muscle cells (VSMCs). In this study, we aim to explore whether Ang II has a role in the expression of CX3CL1/CX3CR1, thus contributing to the proliferation and pro-inflammatory status of VSMCs. Cultured mouse aortic VSMCs were stimulated with 100 nmol/L of Ang II, and the expression of CX3CR1 was assessed by western blot...
January 22, 2018: Inflammation
https://www.readbyqxmd.com/read/29350446/differential-gene-expression-in-trigeminal-ganglia-of-male-and-female-rats-following-chronic-constriction-of-the-infraorbital-nerve
#17
O A Korczeniewska, S Husain, J Khan, E Eliav, P Soteropoulos, R Benoliel
BACKGROUND: The mechanisms underlying sex-based differences in pain and analgesia are poorly understood. In this study, we investigated gene expression changes in trigeminal ganglia (TG) of male and female rats exposed to infraorbital nerve chronic constriction injury (IoN-CCI). METHODS: Somatosensory assessments were performed prior to IoN-CCI and at selected time points postsurgery. Selected gene expression changes were examined with real-time quantitative polymerase chain reaction (RT-PCR) in ipsilateral TG at 21 days postsurgery...
January 19, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29326275/cx3cr1-mononuclear-phagocytes-control-immunity-to-intestinal-fungi
#18
Irina Leonardi, Xin Li, Alexa Semon, Dalin Li, Itai Doron, Gregory Putzel, Agnieszka Bar, Daniel Prieto, Maria Rescigno, Dermot P B McGovern, Jesus Pla, Iliyan D Iliev
Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1+ mononuclear phagocytes (MNPs) as being essential for the initiation of innate and adaptive immune responses to intestinal fungi. CX3CR1+ MNPs express antifungal receptors and activate antifungal responses in a Syk-dependent manner...
January 12, 2018: Science
https://www.readbyqxmd.com/read/29323156/ischemia-induced-neuronal-cell-death-is-mediated-by-chemokine-receptor-cx3cr1
#19
Jinkun Wang, Yan Gan, Pengcheng Han, Junxiang Yin, Qingwei Liu, Soha Ghanian, Feng Gao, Guanghui Gong, Zhiwei Tang
The chemokine fractalkine (CX3CL1) and its receptor CX3CR1 play a fundamental role in the pathophysiology of stroke. Previous studies have focused on a paracrine interaction between neurons that produce fractalkine and microglia that express CX3CR1 receptors in the central nervous system. Recent findings have demonstrated the functional expression of CX3CR1 receptors by hippocampal neurons, suggesting their involvement in neuroprotective and neurodegenerative actions. To elucidate the roles of neuronal CX3CR1 in neurodegeneration induced by ischemic stroke, a mouse model of permanent middle cerebral artery occlusion (pMCAO) was employed...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311541/yolk-sac-macrophage-progenitors-traffic-to-the-embryo-during-defined-stages-of-development
#20
C Stremmel, R Schuchert, F Wagner, R Thaler, T Weinberger, R Pick, E Mass, H C Ishikawa-Ankerhold, A Margraf, S Hutter, R Vagnozzi, S Klapproth, J Frampton, S Yona, C Scheiermann, J D Molkentin, U Jeschke, M Moser, M Sperandio, S Massberg, F Geissmann, C Schulz
Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo...
January 8, 2018: Nature Communications
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