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https://www.readbyqxmd.com/read/29928570/bioinformatic-screening-for-key-mirnas-and-genes-associated-with-myocardial-infarction
#1
Ke Wu, Qiang Zhao, Zhengmei Li, Nannan Li, Qiang Xiao, Xiuchang Li, Quanming Zhao
Despite significant advances in understanding of the causes of and treatment of myocardial infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was to identify miRNA and genes potentially associated with MI. mRNA and miRNA expression datasets were downloaded from the Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo/). Interactions between miRNA and the expression and function of target genes were analyzed, and a protein-protein interaction network was constructed...
June 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29926064/-roles-of-cx3cr1-in-mediation-of-post-incision-induced-mechanical-pain-hypersensitivity-effects-of-acupuncture-combined-anesthesia
#2
Chao Li, Wei Mao, Yun-Ke Huang, Zhi-Qi Zhao, Ning Lyu
Post-incision pain often occurs after surgery and is emergent to be treated in clinic. It hinders the rehabilitation of patients and easily leads to various types of postoperative complications. Acupuncture-combined anesthesia (ACA) is the combination of traditional acupuncture and modern anesthesia, which means acupuncture is applied at acupoints with general anesthesia. It was testified that ACA strengthened the analgesic effect and reduced the occurrence of postoperative pain, but its mechanism was not clear...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29917067/adhesive-interactions-between-mononuclear-phagocytes-and-intestinal-epithelium-perturb-normal-epithelial-differentiation-and-serve-as-a-therapeutic-target-in-inflammatory-bowel-disease
#3
Sozaburo Ihara, Yoshihiro Hirata, Yohko Hikiba, Aya Yamashita, Mayo Tsuboi, Masahiro Hata, Mitsuru Konishi, Nobumi Suzuki, Kosuke Sakitani, Hiroto Kinoshita, Yoku Hayakawa, Hayato Nakagawa, Hideaki Ijichi, Keisuke Tateishi, Kazuhiko Koike
Background and Aims: Disturbance of intestinal homeostasis is associated with the development of inflammatory bowel disease (IBD), and TGF-β signaling impairment in mononuclear phagocytes (MPs) causes murine colitis with goblet cell depletion. Here, we examined an organoid-MP co-culture system to study the role of MPs in intestinal epithelial differentiation and homeostasis. Methods: Intestinal organoids were co-cultured with lamina propria leukocytes and bone marrow-derived dendritic cells (BMDCs) from CD11c-cre Tgfbr2fl/fl mice...
June 16, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29911608/increased-c-fiber-response-induced-by-experimental-disc-herniation-is-associated-with-upregulation-of-fractalkine-and-its-receptor-in-nucleus-pulposus-and-dorsal-root-ganglion
#4
D P Jacobsen, A Moen, F Haugen, J Gjerstad
Aims Lumbar radicular pain following intervertebral disc herniation may be caused by a local inflammatory response induced by nucleus pulposus (NP) cells. Here in an animal model mimicking the clinical situation following disc herniation we investigated the effect of NP on the spinal nociceptive signaling and local gene expression. Methods In anaesthetized Lewis rats, extracellular single unit recordings of spinal nociceptive activity and qPCR were used to explore the effect of NP application onto the dorsal nerve roots (L3-L5)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909495/the-neuro-immune-regulators-niregs-promote-tissue-resilience-a-vital-component-of-the-host-s-defense-strategy-against-neuroinflammation
#5
REVIEW
Yosra Bedoui, Jim W Neal, Philippe Gasque
An effective protective inflammatory response in the brain is crucial for the clearance of pathogens (e.g. microbes, amyloid fibrils, prionSC ) and should be closely regulated. However, the CNS seems to have limited tissue resilience to withstand the detrimental effects of uncontrolled inflammation compromising functional recovery and tissue repair. Newly described neuro-immune-regulators (NIREGs) are functionally related proteins regulating the severity and duration of the host inflammatory response. NIREGs such as CD200, CD47 and CX3CL1 are vital for increasing tissue resilience and are constitutively expressed by neurons...
June 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29909020/diet-modifies-colonic-microbiota-and-cd4-t-cell-repertoire-to-induce-flares-of-colitis-in-mice-with-myeloid-cell-expression-of-interleukin-23
#6
Lili Chen, Zhengxiang He, Alina Cornelia Iuga, Sebastião N Martins Filho, Jeremiah J Faith, Jose C Clemente, Madhura Deshpande, Anitha Jayaprakash, Jean-Frederic Colombel, Juan J Lafaille, Ravi Sachidanandam, Glaucia C Furtado, Sergio A Lira
BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. METHODS: All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29877129/longitudinal-mri-analysis-and-histological-characterization-after-spinal-cord-injury-in-two-mouse-strains-with-different-functional-recovery-gliosis-as-a-key-factor
#7
Harun Najib Noristani, Guillaume Patrick Saint-Martin, Maida Cardoso, Rahima Sidiboulenouar, Mathias Catteau, Christophe Coillot, Christophe Goze-Bac, Florence Evelyne Perrin
Spinal cord injuries (SCI) are disastrous neuropathologies causing permanent disabilities. The availability of different strains of mice is valuable for studying the pathophysiological mechanisms involved in SCI. However, strain differences have a profound effect on spontaneous functional recovery after SCI. CX3CR1+/eGFP and Aldh1l1-EGFP mice that express green fluorescent protein in microglia/monocytes and astrocytes respectively are particularly useful to study glial reactivity. Whereas CX3CR1+/eGFP mice have C57BL/6 background, Aldh1l1-EGFP are in Swiss Webster background...
June 7, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29872403/circulating-endothelial-progenitor-cells-present-an-inflammatory-phenotype-and-function-in-patients-with-alcoholic-liver-cirrhosis
#8
Savneet Kaur, Rashi Sehgal, Saggere M Shastry, Geoffrey McCaughan, Helen M McGuire, Barbara Fazekas St de Groth, Shiv Sarin, Nirupma Trehanpati, Devanshi Seth
Background and Aim: Endothelial progenitor cells (EPCs) have been implicated in liver injury and repair. However, the phenotype and potential of these heterogenous EPCs remain elusive. In particular, their involvement in the pathogenesis of alcoholic liver cirrhosis (ALC) remains unclear. The current study extensively characterized the phenotype and functions of EPCs to understand their role in ALC pathogenesis. Methods: Circulating EPCs were identified as CD34+CD133+CD31+ cells by flow cytometer in ALC patients ( n = 7) and healthy controls (HC, n = 7)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29870777/central-fractalkine-stimulates-central-prostaglandin-e-2-production-and-induces-systemic-inflammatory-responses
#9
Clarissa M D Mota, José Antunes-Rodrigues, Luiz G S Branco
Fractalkine (FKN; CX3CL1) belongs to gamma-chemokine family and binds to CX3CR1 receptors. Currently, the mechanisms involving FKN-induced inflammatory mediators are research targets in an attempt to study immune diseases mechanisms. Besides, FKN seems to modulate inflammation in the nervous system by inducing the secretion of pro-inflammatory mediators such as prostaglandin E2 (PGE2 ). PGE2 is a classic and important mediator of fever that activates warm-responsive neurons in the anteroventral preoptic region of the hypothalamus (AVPO)...
June 2, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29869839/pro-inflammatory-cx3cr1-cd59-tl1a-il-23-monocytes-are-expanded-in-patients-with-ankylosing-spondylitis-and-modulate-ilc3-immune-functions
#10
Francesco Ciccia, Giuliana Guggino, Michael Zeng, Ranjeny Thomas, Vidya Ranganathan, Arifur Rahman, Riccardo Alessandro, Aroldo Rizzo, Laura Saieva, Federica Macaluso, Sergio Peralta, Diana Di Liberto, Francesco Dieli, Paola Cipriani, Roberto Giacomelli, Dominique Baeten, Nigil Haroon
OBJECTIVE: Gut derived ILC3 have been demonstrated to participate in AS pathogenesis. CX3CR1+ mononuclear phagocytes (MNP) have been demonstrated to modulate ILC3 function in the gut. The aim of this study was to study the role of pro-inflammatory CX3CR1+ CD59+ MNP in modulating ILC3 function in AS patients. METHODS: MNP subsets in blood were analysed by flow cytometry in AS patients and controls. Tissue presence of CX3CR1+ CD59+ cells was confirmed by confocal microscopy...
June 5, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29863495/renal-immune-surveillance-and-dipeptidase-1-contribute-to-contrast-induced-acute-kidney-injury
#11
Arthur Lau, Hyunjae Chung, Takanori Komada, Jaye M Platnich, Christina F Sandall, Saurav Roy Choudhury, Justin Chun, Victor Naumenko, Bas Gj Surewaard, Michelle C Nelson, Annegret Ulke-Lemée, Paul L Beck, Hallgrimur Benediktsson, Anthony M Jevnikar, Sarah L Snelgrove, Michael J Hickey, Donna L Senger, Matthew T James, Justin A Macdonald, Paul Kubes, Craig N Jenne, Daniel A Muruve
Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3-deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI (CI-AKI). Unexpectedly, contrast agents directly induced tubular epithelial cell death in vitro that was not dependent on Nlrp3. Rather, contrast agents activated the canonical Nlrp3 inflammasome in macrophages. Intravital microscopy revealed diatrizoate (DTA) uptake within minutes in perivascular CX3CR1+ resident phagocytes in the kidney...
June 4, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29850876/immunohistochemical-and-molecular-investigations-show-alteration-in-the-inflammatory-profile-of-multiple-system-atrophy-brain
#12
Aoife P Kiely, Christina E Murray, Sandrine C Foti, Bridget C Benson, Robert Courtney, Catherine Strand, Tammaryn Lashley, Janice L Holton
Multiple system atrophy (MSA) is an adult-onset neurodegenerative disease characterized by aggregation of α-synuclein in oligodendrocytes to form glial cytoplasmic inclusions. According to the distribution of neurodegeneration, MSA is subtyped as striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA), or as combination of these 2 (mixed MSA). In the current study, we aimed to investigate regional microglial populations and gene expression in the 3 different MSA subtypes. Microscopy with microglial marker Iba-1 combined with either proinflammatory marker CD68 or anti-inflammatory marker Arginase-1 was analyzed in control, SND, and OPCA cases (n = 5) using paraffin embedded sections...
April 23, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29844029/diverse-inflammatory-response-after-cerebral-microbleeds-includes-coordinated-microglial-migration-and-proliferation
#13
Sung Ji Ahn, Josef Anrather, Nozomi Nishimura, Chris B Schaffer
BACKGROUND AND PURPOSE: Cerebral microbleeds are linked to cognitive decline, but it remains unclear how they impair neuronal function. Infarction is not typically observed near microbleeds, suggesting more subtle mechanisms, such as inflammation, may play a role. Because of their small size and largely asymptomatic nature, real-time detection and study of spontaneous cerebral microbleeds in humans and animal models are difficult. METHODS: We used in vivo 2-photon microscopy through a chronic cranial window in adult mice to follow the inflammatory response after a cortical microhemorrhage of ≈100 µm diameter, induced by rupturing a targeted cortical arteriole with a laser...
May 29, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29794822/zidovudine-based-treatments-inhibit-the-glycosylation-of-adam17-and-reduce-cd163-shedding-from-monocytes
#14
Song Chen, Xiaoyu Wang, Haipeng Zhu, Qin Tang, Wei DU, Huanhuan Cao, Chunhui Lai, Weizhong Guo, Linchun Fu, Wei Lu
BACKGROUND: sCD163, a biomarker of monocyte-macrophage activation, has been identified as a predictor of all-cause mortality in treated HIV-infected individuals. Nevertheless, little is known about whether different antiretroviral drugs differentially regulate sCD163 levels and monocyte activation. METHODS: A total of 123 patients receiving zidovudine (ZDV)-based (n = 55) or tenofovir disoproxil fumarate (TDF)-based (n = 68) antiretroviral regimens were enrolled, and their viral loads, CD4 counts, as well as plasma sCD163 and sCD14 levels were quantified...
May 23, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29787933/thd-tricluster-a-robust-triclustering-technique-and-its-application-in-condition-specific-change-analysis-in-hiv-1-progression-data
#15
Tulika Kakati, Hasin A Ahmed, Dhruba K Bhattacharyya, Jugal K Kalita
Developing a cost-effective and robust triclustering algorithm that can identify triclusters of high biological significance in the gene-sample-time (GST) domain is a challenging task. Most existing triclustering algorithms can detect shifting and scaling patterns in isolation, they are not able to handle co-occurring shifting-and-scaling patterns. This paper makes an attempt to address this issue. It introduces a robust triclustering algorithm called THD-Tricluster to identify triclusters over the GST domain...
May 7, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29785023/hiv-vaccine-candidate-activation-of-hypoxia-and-the-inflammasome-in-cd14-monocytes-is-associated-with-a-decreased-risk-of-siv-mac251-acquisition
#16
Monica Vaccari, Slim Fourati, Shari N Gordon, Dallas R Brown, Massimilano Bissa, Luca Schifanella, Isabela Silva de Castro, Melvin N Doster, Veronica Galli, Maria Omsland, Dai Fujikawa, Giacomo Gorini, Namal P M Liyanage, Hung V Trinh, Katherine M McKinnon, Kathryn E Foulds, Brandon F Keele, Mario Roederer, Richard A Koup, Xiaoying Shen, Georgia D Tomaras, Marcus P Wong, Karissa J Munoz, Johannes S Gach, Donald N Forthal, David C Montefiori, David J Venzon, Barbara K Felber, Margherita Rosati, George N Pavlakis, Mangala Rao, Rafick-Pierre Sekaly, Genoveffa Franchini
Qualitative differences in the innate and adaptive responses elicited by different HIV vaccine candidates have not been thoroughly investigated. We tested the ability of the Aventis Pasteur live recombinant canarypox vector (ALVAC)-SIV, DNA-SIV and Ad26-SIV vaccine prime modalities together with two ALVAC-SIV + gp120 protein boosts to reduce the risk of SIVmac251 acquisition in rhesus macaques. We found that the DNA and ALVAC prime regimens were effective, but the Ad26 prime was not. The activation of hypoxia and the inflammasome in CD14+ CD16- monocytes, gut-homing CCR5-negative CD4+ T helper 2 (TH 2) cells and antibodies to variable region 2 correlated with a decreased risk of SIVmac251 acquisition...
May 21, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29750189/repopulating-retinal-microglia-restore-endogenous-organization-and-function-under-cx3cl1-cx3cr1-regulation
#17
Yikui Zhang, Lian Zhao, Xu Wang, Wenxin Ma, Adam Lazere, Hao-Hua Qian, Jun Zhang, Mones Abu-Asab, Robert N Fariss, Jerome E Roger, Wai T Wong
Microglia have been discovered to undergo repopulation following ablation. However, the functionality of repopulated microglia and the mechanisms regulating microglia repopulation are unknown. We examined microglial homeostasis in the adult mouse retina, a specialized neural compartment containing regular arrays of microglia in discrete synaptic laminae that can be directly visualized. Using in vivo imaging and cell-fate mapping techniques, we discovered that repopulation originated from residual microglia proliferating in the central inner retina that subsequently spread by centrifugal migration to fully recapitulate pre-existing microglial distributions and morphologies...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29743615/human-intestinal-pro-inflammatory-cd11c-high-ccr2-cx3cr1-macrophages-but-not-their-tolerogenic-cd11c-ccr2-cx3cr1-counterparts-are-expanded-in-inflammatory-bowel-disease
#18
D Bernardo, A C Marin, S Fernández-Tomé, A Montalban-Arques, A Carrasco, E Tristán, L Ortega-Moreno, I Mora-Gutiérrez, A Díaz-Guerra, R Caminero-Fernández, P Miranda, F Casals, M Caldas, M Jiménez, S Casabona, F De la Morena, M Esteve, C Santander, M Chaparro, J P Gisbert
Although macrophages (Mϕ) maintain intestinal immune homoeostasis, there is not much available information about their subset composition, phenotype and function in the human setting. Human intestinal Mϕ (CD45+ HLA-DR+ CD14+ CD64+ ) can be divided into subsets based on the expression of CD11c, CCR2 and CX3CR1. Monocyte-like cells can be identified as CD11chigh CCR2+ CX3CR1+ cells, a phenotype also shared by circulating CD14+ monocytes. On the contrary, their Mϕ-like tissue-resident counterparts display a CD11c- CCR2- CX3CR1- phenotype...
May 9, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29743344/cx3cr1-does-not-universally-mediate-microglia-neuron-crosstalk-during-synaptic-plasticity
#19
Patrick Miller-Rhodes
No abstract text is available yet for this article.
May 9, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29739975/prismplus-a-mouse-line-expressing-distinct-fluorophores-in-four-different-brain-cell-types
#20
Janak Gaire, Heui Chang Lee, Ray Ward, Seth Currlin, Andrew J Woolley, Jason E Coleman, Justin C Williams, Kevin J Otto
To screen the complex central nervous system (CNS) injury responses, we created a quadruple-labelled 'PrismPlus' mouse line with a genetically encoded distinct fluorescent tag in oligodendrocytes, microglia, neurons, and astrocytes. Cx3cr1-gfp and Prism mice originally developed by Jung et al., 2000 and Dougherty et al., 2012, respectively, were cross-bred. First, we confirmed the presence of fluorophores in appropriate cell types in PrismPlus mice. PrismPlus mice were then used to examine the cellular responses to brain implanted micro-devices...
May 8, 2018: Scientific Reports
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