keyword
https://read.qxmd.com/read/38537205/18f-fet-pet-ct-in-calcifying-pseudoneoplasm-of-the-neuraxis-first-case
#1
JOURNAL ARTICLE
Demetrio Aricò, Giulia Giacoppo, Michelangelo Bambaci, Lorenza Marino, Andrea Girlando, Giuseppe Sortino, Giorgia Leone, Bethania Fernandes, Marco Alì, Laura Evangelista, Alberto Romano
A 66-year-old man has been treated in a psychiatric department for 4-5 years for a depressive syndrome, which is associated with poor motor initiative, confusional state, and dysosmia. Dynamic 18F-FET PET/CT showed only faint uptake of radiotracer just above the background on the left frontal calcific lesion. The time-activity curve of the neoplasms showed a descending pattern. After a left fronto-orbitary minicraniotomy surgery, histology examination concluded for a rare calcifying pseudoneoplasm of the neuraxis (CAPNON)...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537188/multimodal-ultrasonography-evaluation-in-thyroid-nodule-characterization-what-is-the-ideal-algorithm
#2
JOURNAL ARTICLE
Başak Erdemli Gürsel, Barış Çağlar, Rıfat Özpar, Özlem Saraydaroğlu, Gökhan Gökalp, Naile Bolca Topal
AIMS: The aim of this study is to investigate the diagnostic performances of Ultrasonography (US), Shear-wave Elastography (SWE), and Superb Microvascular Imaging (SMI) findings in the diagnosis of malignant thyroid nodules (MTNs) and to determine the US algorithm with the best diagnostic performance. MATERIAL AND METHODS: Eighty-one nodules in 77 patients who had underwent multimodal US with biopsy results, were evaluated. Echogenicity, nodule components, contours, presence and type of calcification, and size were analyzed with US...
March 27, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38535261/surface-treatment-of-dental-mini-sized-implants-and-screws-a-systematic-review-with-meta-analysis
#3
REVIEW
Ana Luísa Figueiredo, Raquel Travassos, Catarina Nunes, Madalena Prata Ribeiro, Mariana Santos, Flavia Iaculli, Anabela Baptista Paula, Carlos Miguel Marto, Francisco Caramelo, Inês Francisco, Francisco Vale
Miniscrews are devices that allow for absolute skeletal anchorage. However, their use has a higher failure rate (10-30%) than dental implants (10%). To overcome these flaws, chemical and/or mechanical treatment of the surface of miniscrews has been suggested. There is no consensus in the current literature about which of these methods is the gold standard; thus, our objective was to carry out a systematic review and meta-analysis of the literature on surface treatments of miniscrews. The review protocol was registered (PROSPERO CRD42023408011) and is in accordance with the PRISMA guidelines...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535084/novel-biomarkers-in-evaluating-cardiac-function-in-patients-on-hemodialysis-a-pilot-prospective-observational-cohort-study
#4
JOURNAL ARTICLE
Lazar Chisavu, Viviana Mihaela Ivan, Adelina Mihaescu, Flavia Chisavu, Oana Schiller, Luciana Marc, Flaviu Bob, Adalbert Schiller
Chronic kidney disease patients treated by hemodialysis present a high cardiovascular morbidity and mortality. There is an imperative need for novel biomarkers for identifying these patients and to offer possible therapeutically interventions. We performed a prospective observational cohort study on 77 patients in the period of October 2021-October 2023. We measured serum plasma levels of interleukin 1-beta, galectin 3, human suppression of tumorigenicity factor 2, bone morphogenetic protein 2 and fibroblastic growth factor 23 at the inclusion site...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534844/sporopollenin-capsules-as-biomimetic-templates-for-the-synthesis-of-hydroxyapatite-and-%C3%AE-tcp
#5
JOURNAL ARTICLE
Arianna De Mori, Daniel Quizon, Hannah Dalton, Berzah Yavuzyegit, Guido Cerri, Milan Antonijevic, Marta Roldo
Pollen grains, with their resilient sporopollenin exine and defined morphologies, have been explored as bio-templates for the synthesis of calcium phosphate minerals, particularly hydroxyapatite (HAp) and β-tricalcium phosphate (TCP). Various pollen morphologies from different plant species (black alder, dandelion, lamb's quarters, ragweed, and stargazer lily) were evaluated. Pollen grains underwent acid washing to remove allergenic material and facilitate subsequent calcification. Ragweed and lamb's quarter pollen grains were chosen as templates for calcium phosphate salts deposition due to their distinct morphologies...
March 4, 2024: Biomimetics
https://read.qxmd.com/read/38534325/indoxyl-sulfate-induced-valve-endothelial-cell-endothelial-to-mesenchymal-transition-and-calcification-in-an-integrin-linked-kinase-dependent-manner
#6
JOURNAL ARTICLE
Maria Delgado-Marin, Sandra Sánchez-Esteban, Alberto Cook-Calvete, Sara Jorquera-Ortega, Carlos Zaragoza, Marta Saura
Calcific Aortic Valve Disease (CAVD) is a significant concern for cardiovascular health and is closely associated with chronic kidney disease (CKD). Aortic valve endothelial cells (VECs) play a significant role in the onset and progression of CAVD. Previous research has suggested that uremic toxins, particularly indoxyl sulfate (IS), induce vascular calcification and endothelial dysfunction, but the effect of IS on valve endothelial cells (VECs) and its contribution to CAVD is unclear. Our results show that IS reduced human VEC viability and increased pro-calcific markers RUNX2 and alkaline phosphatase (ALP) expression...
March 8, 2024: Cells
https://read.qxmd.com/read/38533488/a-unique-late-onset-intraocular-lens-opacification-23%C3%A2-years-after-implantation-a-clinical-and-laboratory-case-report
#7
Panos S Gartaganis, Panagiota D Natsi, Sotirios P Gartaganis, Petros G Koutsoukos, Horst Helbig
We report an unusual, rare case of opacification of the hydrophilic acrylic intraocular lens (IOL) 23 years after the initial surgery with significant visual deterioration. Opacification of the hydrophilic acrylic IOL was primarily due to the formation of folds on the surface of the lens material, and less so due to calcium phosphate deposits. Calcification opacification can be attributed to recent events, as evidenced by deposits of dicalcium phosphate dihydrate (CaHPO4 2H2 O) and octacalcium phosphate (Ca8 H2 (PO4 )6 5H2 O), both of which are transient calcium phosphate phases, converting hydrolytically to the thermodynamically most stable hydroxyapatite (Ca10 (PO4 )6 (OH)2 )...
2024: Therapeutic Advances in Ophthalmology
https://read.qxmd.com/read/38531147/mob-cbam-a-dual-channel-attention-based-deep-learning-generalizable-model-for-breast-cancer-molecular-subtypes-prediction-using-mammograms
#8
JOURNAL ARTICLE
Iqra Nissar, Shahzad Alam, Sarfaraz Masood, Mohammad Kashif
BACKGROUND AND OBJECTIVE: Deep Learning models have emerged as a significant tool in generating efficient solutions for complex problems including cancer detection, as they can analyze large amounts of data with high efficiency and performance. Recent medical studies highlight the significance of molecular subtype detection in breast cancer, aiding the development of personalized treatment plans as different subtypes of cancer respond better to different therapies. METHODS: In this work, we propose a novel lightweight dual-channel attention-based deep learning model MOB-CBAM that utilizes the backbone of MobileNet-V3 architecture with a Convolutional Block Attention Module to make highly accurate and precise predictions about breast cancer...
March 10, 2024: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/38530954/differences-in-plasma-fatty-acid-composition-related-to-chronic-pancreatitis-a-pilot-study
#9
JOURNAL ARTICLE
Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate
OBJECTIVES: Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP. MATERIALS AND METHODS: Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22)...
March 13, 2024: Pancreas
https://read.qxmd.com/read/38530430/quantitative-susceptibility-mapping-for-detection-of-kidney-stones-hemorrhage-differentiation-and-cyst-classification-in-adpkd
#10
JOURNAL ARTICLE
Karl Schumacher, Martin R Prince, Jon D Blumenfeld, Hanna Rennert, Zhongxiu Hu, Hreedi Dev, Yi Wang, Alexey V Dimov
BACKGROUND AND PURPOSE: The objective is to demonstrate feasibility of quantitative susceptibility mapping (QSM) in autosomal dominant polycystic kidney disease (ADPKD) patients and to compare imaging findings with traditional T1/T2w magnetic resonance imaging (MRI). METHODS: Thirty-three consecutive patients (11 male, 22 female) diagnosed with ADPKD were initially selected. QSM images were reconstructed from the multiecho gradient echo data and compared to co-registered T2w, T1w, and CT images...
March 26, 2024: Abdominal Radiology
https://read.qxmd.com/read/38530406/opportunistic-identification-of-vertebral-compression-fractures-on-ct-scans-of-the-chest-and-abdomen-using-an-ai-algorithm-in-a-real-life-setting
#11
JOURNAL ARTICLE
Magnus Grønlund Bendtsen, Mette Friberg Hitz
This study evaluated the performance of a vertebral fracture detection algorithm (HealthVCF) in a real-life setting and assessed the impact on treatment and diagnostic workflow. HealthVCF was used to identify moderate and severe vertebral compression fractures (VCF) at a Danish hospital. Around 10,000 CT scans were processed by the HealthVCF and CT scans positive for VCF formed both the baseline and 6-months follow-up cohort. To determine performance of the algorithm 1000 CT scans were evaluated by specialized radiographers to determine performance of the algorithm...
March 26, 2024: Calcified Tissue International
https://read.qxmd.com/read/38530180/virtual-noncontrast-ct-for-coronary-artery-calcification-scoring-using-photon-counting-ct
#12
EDITORIAL
Hajime Sakuma
No abstract text is available yet for this article.
March 2024: Radiology
https://read.qxmd.com/read/38530015/hypomethylation-of-the-lncrna-h19-promoter-accelerates-osteogenic-differentiation-of-vascular-smooth-muscle-cells-by-activating-the-erk1-2-pathways
#13
JOURNAL ARTICLE
Taoxia Wang, Meijuan Cheng, Jingjing Jin, Yaling Bai, Dongxue Zhang, Shenglei Zhang, Jinsheng Xu
OBJECTIVE: Vascular calcification is a common chronic kidney disease complication. This study aimed to investigate the function of long non-coding RNA (LncRNA) H19 in vascular calcification to explore new therapeutic strategies. METHODS: We induced osteogenic differentiation and calcification of vascular smooth muscle cells (VSMCs) using β-glycerophosphate. Then, we detected the LncRNA H19 promoter methylation status and Erk1/2 pathways using methylation-specific polymerase chain reaction and western blotting, respectively...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38529825/diamond-burr-debridement-of-calcific-band-keratopathy-in-24-eyes-of-22-horses
#14
JOURNAL ARTICLE
Sophie Jugant, Alain Regnier, Jean-Yves Douet
PURPOSE: To evaluate the safety and effectiveness of diamond burr debridement (DBD) for the treatment of calcific band keratopathy (CBK) in horses. METHODS: Medical records from horses with CBK were reviewed over a period of 4 years. Diagnosis of CBK was based on slit-lamp examination findings, and DBD was performed on standing sedated horses. Follow-up was obtained by clinical reevaluation of the treated eyes or a telephone survey with the referring veterinarian...
March 26, 2024: Veterinary Ophthalmology
https://read.qxmd.com/read/38529637/acurate-neo2-versus-sapien-3-ultra-transcatheter-heart-valve-in-severe-aortic-valve-calcification-a-propensity-matched-analysis
#15
JOURNAL ARTICLE
Clemens Eckel, Won-Keun Kim, Dagmar Sötemann, Christina Grothusen, Vedat Tiyerili, Guido Dohmen, Matthias Renker, Efstratios I Charitos, Christian W Hamm, Yeong-Hoon Choi, Albrecht Elsässer, Helge Möllmann, Johannes Blumenstein
BACKGROUND: Comparative data on transcatheter self-expanding ACURATE neo2 (NEO2) and balloon-expandable SAPIEN 3 Ultra prostheses in technically challenging anatomy of severe aortic valve calcified aortic annuli are scarce. METHODS: A total of 1987 patients with severe native aortic stenosis treated with the self-expanding NEO2 (n=1457) or balloon-expandable SAPIEN 3 Ultra (n=530) from January 2017 to April 2023 were evaluated. The primary end point was procedural outcome according to the Valve Academic Research Consortium 3 definitions...
March 26, 2024: Circulation. Cardiovascular Interventions
https://read.qxmd.com/read/38529436/penile-calciphylaxis-a-successfully-treated-case
#16
Narine Misakyan, Amer Abu-Shanab, Shazia Shah
Penile calciphylaxis is a rare presentation of calcific uremic arteriolopathy and can be a life-threatening condition usually seen in patients with end-stage renal failure with hemodialysis. The clear etiopathogenesis of calciphylaxis is not fully understood, but it is postulated to be characterized by the accumulation of calcium in the microvessels of adipose tissue and skin, which leads to ischemia and necrosis, causing painful ulcerations, and could potentially be complicated by sepsis and mortality...
February 2024: Curēus
https://read.qxmd.com/read/38529394/ultrasound-guided-fine-needle-aspiration-thyroglobulin-in-the-diagnosis-of-lymph-node-metastasis-of-differentiated-papillary-thyroid-carcinoma-and-its-influencing-factors
#17
JOURNAL ARTICLE
Xuejiao Su, Lei Shang, Can Yue, Buyun Ma
BACKGROUND: Ultrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear. METHOD: In this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC, encompassing 333 lymph nodes. We analyze the optimal cutoff value and diagnostic efficacy of FNA-Tg, while also evaluating the potential influence of various factors on FNA-Tg...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529115/recent-advances-in-the-therapeutic-management-of-calcium-pyrophosphate-deposition-disease
#18
REVIEW
Paraskevi V Voulgari, Aliki I Venetsanopoulou, Alexandros A Drosos
Calcium pyrophosphate deposition (CPPD) disease is a form of crystal-induced arthropathy that arises from the accumulation of calcium pyrophosphate crystals within joints and soft tissues. This process leads to inflammation and damage to the affected joints. It can present asymptomatically or as acute or chronic inflammatory arthritis. Risk factors and comorbidities, including prior joint injury, osteoarthritis, hereditary or familial predisposition, and metabolic diseases, should be evaluated in CPPD cases...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38529079/automated-plaque-detection-and-agatston-score-estimation-on-non-contrast-ct-scans-a-multicenter-study
#19
Andrew M Nguyen, Jianfei Liu, Tejas Sudharshan Mathai, Peter C Grayson, Ronald M Summers
Coronary artery calcification (CAC) is a strong and independent predictor of cardiovascular disease (CVD). However, manual assessment of CAC often requires radiological expertise, time, and invasive imaging techniques. The purpose of this multicenter study is to validate an automated cardiac plaque detection model using a 3D multiclass nnU-Net for gated and non-gated non-contrast chest CT volumes. CT scans were performed at three tertiary care hospitals and collected as three datasets, respectively. Heart, aorta, and lung segmentations were determined using TotalSegmentator, while plaques in the coronary arteries and heart valves were manually labeled for 801 volumes...
February 14, 2024: ArXiv
https://read.qxmd.com/read/38529036/clinical-presentation-and-diagnosis-of-adult-onset-leukoencephalopathy-with-axonal-spheroids-and-pigmented-glia-a-literature-analysis-of-case-studies
#20
JOURNAL ARTICLE
Spyros Papapetropoulos, Jeffrey M Gelfand, Takuya Konno, Takeshi Ikeuchi, Angela Pontius, Andreas Meier, Farid Foroutan, Zbigniew K Wszolek
INTRODUCTION: Because adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, rapidly progressive, debilitating, and ultimately fatal neurodegenerative disease, a rapid and accurate diagnosis is critical. This analysis examined the frequency of initial misdiagnosis of ALSP via comprehensive review of peer-reviewed published cases. METHODS: Data were extracted from a MEDLINE search via PubMed (January 1, 1980, through March 22, 2022) from eligible published case reports/series for patients with an ALSP diagnosis that had been confirmed by testing for the colony-stimulating factor-1 receptor gene ( CSF1R ) mutation...
2024: Frontiers in Neurology
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