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High response to COH

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https://www.readbyqxmd.com/read/27488698/growth-hormone-co-treatment-within-a-gnrh-agonist-long-protocol-improves-implantation-and-pregnancy-rates-in-patients-undergoing-ivf-et
#1
Xiao-Fang Du, Xin-Hong Yang, Jing Li, Mengmeng Hao, Yi-Hong Guo
OBJECTIVE: The efficacy of growth hormone (GH) co-treatment within a GnRH agonist long regimen, in women with a normal ovarian response to controlled ovarian hyperstimulation (COH), for IVF was assessed. METHODS: This retrospective clinical trial was performed in a private-assisted reproduction centre. The study involved 1114 patients who responded normally to high-dose gonadotropin treatment. The study group of 556 patients was given in a daily subcutaneous injection of 4...
October 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27126581/gonadotrophin-releasing-hormone-antagonists-for-assisted-reproductive-technology
#2
REVIEW
Hesham G Al-Inany, Mohamed A Youssef, Reuben Olugbenga Ayeleke, Julie Brown, Wai Sun Lam, Frank J Broekmans
BACKGROUND: Gonadotrophin-releasing hormone (GnRH) antagonists can be used to prevent a luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH) without the hypo-oestrogenic side-effects, flare-up, or long down-regulation period associated with agonists. The antagonists directly and rapidly inhibit gonadotrophin release within several hours through competitive binding to pituitary GnRH receptors. This property allows their use at any time during the follicular phase...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26634938/premature-progesterone-elevation-does-not-affect-pregnancy-outcome-in-high-responder-patients-undergoing-short-interval-coasting-in-ivf-cycles
#3
Mustafa Acet, Lebriz Hale Aktün, Serdar Başaranoğlu, Betül Yorgunlar, Tuba Acet, Aysegul Deregözü
BACKGROUND We aimed to present the relationship between premature progesterone elevation (PPE) and clinical outcomes in high-responder patients who had a coasting period of <4 days in length due to their high risk of developing ovarian hyperstimulation syndrome (OHSS) and who were treated with a long-acting gonadotropin-releasing hormone agonist (GnRH-agonist) protocol in in vitro fertilization-embryo transfer (IVF-ET) cycles. MATERIAL AND METHODS This retrospective study was conducted at the University Hospital Assisted Reproductive Technology Center...
2015: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/26536862/a-simplified-universal-approach-to-coh-protocol-for-ivf-ultrashort-flare-gnrh-agonist-gnrh-antagonist-protocol-with-tailored-mode-and-timing-of-final-follicular-maturation
#4
Raoul Orvieto
Recently, several new promising modifications have been introduced to clinical practice that may simplify and optimize IVF outcome. In the present opinion paper we present a simplified approach to controlled ovarian hyperstimulation protocol (COH), which combines the benefits of the ultrashort flare GnRH agonist/GnRH antagonist protocol and the personalized tailored mode and timing of ovulation triggering, aiming to improve IVF outcome while eliminating of severe OHSS.In patients at risk to develop severe ovarian hyperstimulation syndrome (OHSS), GnRH agonist (GnRHa) trigger if offered for final follicular maturation...
November 4, 2015: Journal of Ovarian Research
https://www.readbyqxmd.com/read/26357853/optimal-cutoff-value-of-basal-anti-mullerian-hormone-in-iranian-infertile-women-for-prediction-of-ovarian-hyper-stimulation-syndrome-and-poor-response-to-stimulation
#5
Malek Mansour Aghssa, Azam Manshadi Tarafdari, Ensieh Shahrokh Tehraninejad, Mohammad Ezzati, Maryam Bagheri, Zahra Panahi, Saeed Mahdavi, Mehrshad Abbasi
AIM: We intended to establish the threshold of Anti-Mullerian Hormone (AMH) for detection of Ovarian Hyper-Stimulation Syndrome (OHSS) and poor response to treatment in Iranian infertile women. METHODS: Pre-stimulation menstrual cycle day-3 hormonal indices including basal AMH values were measured in 105 infertile women aged 32.5 ± 4.3 years. Patients underwent long GnRH agonist Controlled Ovarian Hyperstimulation (COH) in a referral infertility center (Tehran, Iran)...
2015: Reproductive Health
https://www.readbyqxmd.com/read/26158904/can-highly-sensitive-antim%C3%A3-llerian-hormone-testing-predict-failed-response-to-ovarian-stimulation
#6
Heather R Burks, Lauren Ross, Neisha Opper, Erika Paulson, Frank Z Stanczyk, Karine Chung
OBJECTIVE: To determine whether a newer commercially available antimüllerian hormone (AMH) enzyme-linked immunosorbent assay (picoAMH ELISA, AnshLabs) with a lower threshold of detection is predictive of successful ovarian stimulation in a population of women with diminished ovarian reserve (DOR). DESIGN: Retrospective case-control study. SETTING: University-based IVF program. PATIENT(S): Cases were patients whose first IVF cycle was cancelled for lack of ovarian response (<3 follicles; n = 24)...
September 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/26151992/detection-of-a-microgonadotropinoma-by-magnetic-resonance-imaging-performed-because-of-excellent-response-to-controlled-ovarian-hyperstimulation-despite-elevated-day-3-fsh
#7
J H Check, W Dowland
PURPOSE: To determine if a better response than anticipated to controlled ovarian stimulation in a woman assumed to have diminished oocyte reserve based on an increased day 3 serum follicle stimulating hormone (FSH) level, could be related to a gonadotropinoma. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) with and without gadolinium contrast was used in a woman who made 21 mature oocytes despite a history of day 3 serum FSH as high as 20 mIU/mL. RESULTS: A pituitary microgonadotropinoma was detected...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25932224/could-pretreatment-with-oral-contraceptives-before-pituitary-down-regulation-reduce-the-incidence-of-ovarian-hyperstimulation-syndrome-in-the-ivf-icsi-procedure
#8
Lan Wang, Yiqing Zhao, Xiyuan Dong, Kai Huang, Rui Wang, Licheng Ji, Ya Wang, Hanwang Zhang
The long gonadotrophin releasing-hormone agonists (GnRH-a) protocol of pituitary down regulation was widely used in controlled ovarian hyperstimulation (COH). Some clinicians prefer to use one cycle of oral contraceptives (OC) pretreatment before the traditional long GnRH-a protocol. This study was aimed to investigate whether such pretreatment could reduce the incidence of ovarian hyperstimulation syndrome (OHSS) for patients with different ovarian responses in IVF/ICSI treatment. Participants undergoing IVF/ICSI treatment with long GnRH-a protocol of pituitary down regulation in luteal phase were recruited by their potential risk of OHSS into one group of suspected high responders (227 participants) and the other group of suspected normal responders (665 participants)...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25790842/amh-and-amhr2-polymorphisms-and-amh-serum-level-can-predict-assisted-reproduction-outcomes-a-cross-sectional-study
#9
Carla Peluso, Fernando L A Fonseca, Guilherme G Gastaldo, Denise M Christofolini, Emerson Barchi Cordts, Caio P Barbosa, Bianca Bianco
BACKGROUND: In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult to predict. The standard protocol of ovarian hyperstimulation can result in satisfactory response; however, an unsatisfactory response necessitates FSH dose adjustment or results in ovarian hyperstimulation syndrome (OHSS). Polymorphisms in AMH and AMHR2 genes appear to affect hormone biological activities, thus affecting follicle recruitment and development, leading to infertility...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/25753867/the-comparison-of-microdose-flare-up-and-multiple-dose-antagonist-protocols-based-on-hcg-day-estradiol-e2-progesterone-p-and-p-e2-ratio-among-poor-responder-patients-in-icsi-et-cycles
#10
COMPARATIVE STUDY
M N Cicek, I Kahyaoglu, S Kahyaoglu
OBJECTIVE: Elevated progesterone levels surpassing exact treshold values impede endometrial receptivity and decrease clinical pregnancy rates in different responder patients during assisted reproductive techniques. A progesterone (P): estradiol (E2) ratio of > 1 on the day of hCG administration has also been suggested to be a manifestation of low ovarian reserve. The clinical significance of P/E2 ratio on the day of hCG administration was investigated among poor responder patients...
February 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25673088/stimulatory-effect-of-sesamin-on-hepatic-cytochrome-p450-activities-in-atlantic-salmon-salmo-salar-l-is-not-directly-associated-with-expression-of-genes-related-to-xenobiotic-metabolism
#11
Vladimir Zlabek, AnnaLotta Schiller Vestergren, Sofia Trattner, Liane Wagner, Jana Pickova, Galia Zamaratskaia
1. This study examined hepatic cytochrome P450 (CYP450) response to dietary sesamin in combination with different n-6/n-3 fatty acid ratios in fish diet. Over a period of 4 months, fish were fed seven different experimental diets an n-6/n-3 FA ratio of either 0.5 or 1.0 in combination with two sesamin levels: low sesamin = 1.16 g/kg feed and high sesamin = 5.8 g/kg feed. Control diets did not contain sesamin. 2. The CYP450-associated activities of ethoxyresorufin O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylation (BFCOD), pentoxyresorufin O-depentylase (PROD), coumarin hydroxylase (COH), methoxyresorufin O-deethylase (MROD) and p-nitrophenol hydroxylase (PNPH) were significantly induced by dietary sesamin in a dose-related manner...
2015: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/25373014/a-pharmacogenetic-driven-approach-for-controlled-ovarian-hyperstimulation-by-fsh-treatment
#12
COMPARATIVE STUDY
R Colognato, R Aiello, F Dulcetti, A M Ruggeri, S De Toffol, L Marcato, A M Irollo, C Criscuolo, M F Gangale, F Maggi, G Simoni
AIM: The aim of this study was to develop a pharmacogenetic- (PGx) driven approach for a controlled ovarian hyperstimulation (COH) treatment protocol used for in vitro fertilization procedures. The enrolled patients were genotyped for a single nucleotide polymorphism (SNP) N680S, within the FSHR. METHODS: Seventy-eight women, who had previously received at least two COH cycles without positive fertilization with FSH and AMH values <10 mUI/mL and >0.3 ng/mL respectively were enrolled...
December 2014: Minerva Ginecologica
https://www.readbyqxmd.com/read/25242975/association-between-serum-estradiol-level-on-the-hcg-administration-day-and-ivf-icsi-outcome
#13
Mustafa Kara, Tayfun Kutlu, Kenan Sofuoglu, Belgin Devranoglu, Tansel Cetinkaya
BACKGROUND: Estradiol (E2) is required for follicular development and play an important role in embryo implantation. OBJECTIVE: The aim of this study was to assess the impact of serum E2 levels on the day of hCG administration in IVF-ICSI patients who are performed controlled ovarian hyperstimulation (COH). MATERIALS AND METHODS: A total of 203 women who were undergone one time IVF cyclus were evaluated in this cross sectional study. All the patients were treated either with long protocol or with microdose flare protocol...
January 2012: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25150465/monitoring-of-stimulated-cycles-in-assisted-reproduction-ivf-and-icsi
#14
REVIEW
Irene Kwan, Siladitya Bhattacharya, Angela Kang, Andrea Woolner
BACKGROUND: Traditional monitoring of ovarian hyperstimulation during in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) treatment has included transvaginal ultrasonography (TVUS) plus serum estradiol levels to ensure safe practice by reducing the incidence and severity of ovarian hyperstimulation syndrome (OHSS) whilst achieving the good ovarian response needed for assisted reproduction treatment. The need for combined monitoring (using TVUS and serum estradiol) during ovarian stimulation in assisted reproduction is controversial...
August 24, 2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25134304/failure-to-improve-a-thin-endometrium-in-the-late-proliferative-phase-with-uterine-infusion-of-granulocyte-colony-stimulating-factor
#15
J H Check, R Cohen, J K Choe
PURPOSE: To determine if the treatment with uterine infusion of granulocyte colony-stimulating factor (G-CSF) can improve endometrial thickness in an infertile woman with a double uterus, who consistently showed a thin endometrium in the late proliferative phase either in controlled ovarian hyperstimulation (COH) IVF-ET cycles or with graduated estrogen/sildenafil protocols for frozen embryo transfer (ET). MATERIALS AND METHODS: A single uterine infusion of G-CSF was performed in the late proliferative phase in a woman who only attained a five-mm thickness despite a high dose vaginal and oral estradiol regimen plus sildenafil...
2014: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25104928/hypnotic-induction-is-followed-by-state-like-changes-in-the-organization-of-eeg-functional-connectivity-in-the-theta-and-beta-frequency-bands-in-high-hypnotically-susceptible-individuals
#16
Graham A Jamieson, Adrian P Burgess
Altered state theories of hypnosis posit that a qualitatively distinct state of mental processing, which emerges in those with high hypnotic susceptibility following a hypnotic induction, enables the generation of anomalous experiences in response to specific hypnotic suggestions. If so then such a state should be observable as a discrete pattern of changes to functional connectivity (shared information) between brain regions following a hypnotic induction in high but not low hypnotically susceptible participants...
2014: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/24700398/-mild-vs-long-protocol-for-controlled-ovarian-hyperstimulation-in-patients-with-expected-poor-ovarian-responsiveness-undergoing-in-vitro-fertilization-ivf-a-large-prospective-randomized-trial
#17
RANDOMIZED CONTROLLED TRIAL
Alberto Revelli, Alessandra Chiadò, Paola Dalmasso, Veronica Stabile, Francesca Evangelista, Gemma Basso, Chiara Benedetto
BACKGROUND: This large prospective, randomized study was designed to compare the "mild" protocol with clomiphene citrate, low-dose gonadotropins and a GnRH-antagonist (CC/Gn/GnRH-ant protocol) with the "long" protocol with a GnRH-agonist and high-dose Gn for the controlled ovarian hyperstimulation (COH) of patients with expected poor ovarian responsiveness undergoing IVF. MATERIALS AND METHODS: A total of 695 women with clinical, endocrine and ultrasound characteristics suggesting a low ovarian reserve and a poor responsiveness to COH were recruited and randomly assigned to receive the CC/Gn/GnRH-ant "mild" protocol (mild group, n = 355) or the "long" protocol with high-dose Gn (long group, n = 340)...
July 2014: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/24670307/follicle-stimulating-hormone-receptor-fshr-alternative-skipping-of-exon-2-or-3-affects-ovarian-response-to-fsh
#18
Cengiz Karakaya, Ozlem Guzeloglu-Kayisli, Rebecca J Hobbs, Tsilya Gerasimova, Asli Uyar, Mehmet Erdem, Mesut Oktem, Ahmet Erdem, Seyhan Gumuslu, Deniz Ercan, Denny Sakkas, Pierre Comizzoli, Emre Seli, Maria D Lalioti
Genes critical for fertility are highly conserved in mammals. Interspecies DNA sequence variation, resulting in amino acid substitutions and post-transcriptional modifications, including alternative splicing, are a result of evolution and speciation. The mammalian follicle-stimulating hormone receptor (FSHR) gene encodes distinct species-specific forms by alternative splicing. Skipping of exon 2 of the human FSHR was reported in women of North American origin and correlated with low response to ovarian stimulation with exogenous follicle-stimulating hormone (FSH)...
July 2014: Molecular Human Reproduction
https://www.readbyqxmd.com/read/24526354/low-testosterone-levels-in-women-with-diminished-ovarian-reserve-impair-embryo-implantation-rate-a-retrospective-case-control-study
#19
Qun Lu, Huan Shen, Yang Li, Chunfang Zhang, Cong Wang, Xi Chen, Rong Liang, Lihui Wei
OBJECTIVE: To investigate the association of basal testosterone (T) levels with the outcome of in vitro fertilization (IVF) in women with diminished ovarian reserve (DOR). METHODS: Complete clinical data on the first 223 IVF cycles in women with DOR were retrospectively analyzed. The associations of basal follicle stimulating hormone, luteinizing hormone, estradiol, and T levels with ovarian response and IVF outcome were studied. RESULTS: Basal T levels were significantly different between pregnant and non-pregnant women...
April 2014: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/24454387/discrepancies-between-antimullerian-hormone-and-follicle-stimulating-hormone-in-assisted-reproduction
#20
Munawar Hussain, David Cahill, Valentine Akande, Uma Gordon
Data from 107 women undergoing their first IVF/ICSI were analyzed. Relationships between antimullerian hormone (AMH) and follicle stimulating hormone (FSH) were analyzed after dividing patients into four groups according to AMH/FSH levels. Concordance was noted in 57% of women (both AMH/FSH either normal or abnormal) while 43%of women had discordant values (AMH/FSH one hormone normal and the other abnormal). Group 1 (AMH and FSH in normal range) and group 2 (normal AMH and high FSH) were younger compared to group 3 (low AMH and normal FSH) and group 4 (both AMH/FSH abnormal)...
2013: Obstetrics and Gynecology International
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