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https://www.readbyqxmd.com/read/28918967/accuracy-of-bedside-point-of-care-testing-in-critical-emergency-department-patients
#1
Braden W McIntosh, Jerina Vasek, Maria Taylor, Deborah Le Blanc, Henry C Thode, Adam J Singer
BACKGROUND: Point-of-care (POC) testing reduces laboratory turn-around having the potential to improve timely diagnosis and management. We compared the accuracy of nurse performed POC and core laboratory testing and determined whether deviations between the two were clinically meaningful. METHODS: We performed a prospective, observational study on a convenience sample of 50 critical care ED patients in whom a POC chemistry and hematocrit was ordered. Blood samples were divided into 2 aliquots; one sample was tested by the treating nurse using a handheld POC device and the other sample was tested in the core laboratory...
September 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28906279/the-value-of-point-of-care-cd4-and-laboratory-viral-load-in-tailoring-antiretroviral-therapy-monitoring-strategies-to-resource-limitations
#2
Emily P Hyle, Ilesh V Jani, Katherine L Rosettie, Robin Wood, Benjamin Osher, Stephen Resch, Pamela P Pei, Paolo Maggiore, Kenneth A Freedberg, Trevor Peter, Robert A Parker, Rochelle P Walensky
OBJECTIVE: To examine the clinical and economic value of point-of-care CD4 (POC-CD4) or viral load monitoring compared with current practices in Mozambique, a country representative of the diverse resource limitations encountered by HIV treatment programs in sub-Saharan Africa. DESIGN/METHODS: We use the Cost-Effectiveness of Preventing AIDS Complications-International model to examine the clinical impact, cost (2014 US$), and incremental cost-effectiveness ratio [$/year of life saved (YLS)] of ART monitoring strategies in Mozambique...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28900664/-prehospital-care-for-stroke-patients
#3
REVIEW
C H Nolte, H J Audebert
The effectiveness of thrombolysis or mechanical recanalization for acute stroke is higher, the sooner these therapies are started. Therefore, acute stroke patients need to be evaluated by qualified staff for these therapies as soon as possible. Lay persons need to identify the typical symptoms of stroke as an emergency and act accordingly by calling the emergency medical system (EMS). The EMS team reassesses the symptoms and prompts cerebral imaging. Cerebral imaging is performed ideally in hospitals with a stroke unit where subsequent (stroke) treatments occur...
September 12, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28889209/micro-bead-injection-spectroscopy-for-label-free-automated-determination-of-immunoglobulin-g-in-human-serum
#4
Inês I Ramos, Luís M Magalhães, Luisa Barreiros, Salette Reis, José L F C Lima, Marcela A Segundo
Immunoglobulin G (IgG) represents the major fraction of antibodies in healthy adult human serum, and deviations from physiological levels are a generic marker of disease corresponding to different pathologies. Therefore, screening methods for IgG evaluation are a valuable aid to diagnostics. The present work proposes a rapid, automatic, and miniaturized method based on UV-vis micro-bead injection spectroscopy (μ-BIS) for the real-time determination of human serum IgG with label-free detection. Relying on attachment of IgG in rec-protein G immobilized in Sepharose 4B, a bioaffinity column is automatically assembled, where IgG is selectively retained and determined by on-column optical density measurement...
September 9, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28877177/an-in-vitro-diagnostic-certified-point-of-care-single-nucleotide-test-for-il28b-polymorphisms
#5
Darragh Duffy, Estelle Mottez, Shaun Ainsworth, Tan-Phuc Buivan, Aurelie Baudin, Muriel Vray, Ben Reed, Arnaud Fontanet, Alexandra Rohel, Ventzislava Petrov-Sanchez, Laurent Abel, Ioannis Theodorou, Gino Miele, Stanislas Pol, Matthew L Albert
Numerous genetic polymorphisms have been identified as associated with disease or treatment outcome, but the routine implementation of genotyping into actionable medical care remains limited. Point-of-care (PoC) technologies enable rapid and real-time treatment decisions, with great potential for extending molecular diagnostic approaches to settings with limited medical infrastructure (e.g., CLIA certified diagnostic laboratories). With respect to resource-limited settings, there is a need for simple devices to implement biomarker guided treatment strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28875696/surface-enhanced-raman-spectroscopy-based-sandwich-immunoassays-for-multiplexed-detection-of-zika-and-dengue-viral-biomarkers
#6
Maria Sánchez-Purrà, Marc Carré-Camps, Helena de Puig, Irene Bosch, Lee Gehrke, Kimberly Hamad-Schifferli
Zika and dengue are mosquito-borne diseases that present similar nonspecific symptoms but possess dramatically different outcomes. The first line of defense in epidemic outbreaks are rapid point-of-care diagnostics. Because many outbreaks occur in areas that are resource poor, assays that are easy to use, inexpensive, and require no power have become invaluable in patient treatment, quarantining, and surveillance. Paper-based sandwich immunoassays such as lateral flow assays (LFAs) are attractive as point-of-care solutions as they have the potential for wider deployability than lab-based assays such as PCR...
September 6, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28872829/guest-responsive-metal-organic-frameworks-as-scaffolds-for-separation-and-sensing-applications
#7
Avishek Karmakar, Partha Samanta, Aamod V Desai, Sujit K Ghosh
Metal-organic frameworks (MOFs) have evolved to be next-generation utility materials because of their serviceability in a wide variety of applications. Built from organic ligands with multiple binding sites in conjunction with metal ions/clusters, these materials have found profound advantages over their other congeners in the domain of porous materials. The plethora of applications that these materials encompass has motivated material chemists to develop such novel materials, and the catalogue of MOFs is thus ever-escalating...
September 5, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28866597/a-surface-acoustic-wave-pumped-lensless-microfluidic-imaging-system-for-flowing-cell-detection-and-counting
#8
Xiwei Huang, Umar Farooq, Jin Chen, Yakun Ge, Haijun Gao, Jiangtao Su, Xiang Wang, Shurong Dong, Ji-Kui Luo
The future point-of-care diagnostics requires miniaturizing the existing bulky and expensive bioanalysis instruments, where lab-on-CMOS-chip-based technology can provide a promising solution. In this paper, we presented a surface acoustic wave (SAW) pumped lensless microfluidic imaging system for flowing cell detection and counting. Different from the previous lensless systems, which employ external bulky syringe pump for cell driven, the developed system directly integrates the SAW pump on the CMOS image sensor chip to drive the cell-containing microfluid...
August 29, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28814583/does-use-of-point-of-care-testing-improve-cost-effectiveness-of-the-nhs-health-check-programme-in-the-primary-care-setting-a-cost-minimisation-analysis
#9
Austen El-Osta, Maria Woringer, Elena Pizzo, Talitha Verhoef, Claire Dickie, Melody Z Ni, Jeremy R Huddy, Michael Soljak, George B Hanna, Azeem Majeed
OBJECTIVE: To determine if use of point of care testing (POCT) is less costly than laboratory testing to the National Health Service (NHS) in delivering the NHS Health Check (NHSHC) programme in the primary care setting. DESIGN: Observational study and theoretical mathematical model with microcosting approach. SETTING: We collected data on NHSHC delivered at nine general practices (seven using POCT; two not using POCT). PARTICIPANTS: We recruited nine general practices offering NHSHC and a pathology services laboratory in the same area...
August 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28813013/recent-advances-in-electrospun-nanofiber-interfaces-for-biosensing-devices
#10
REVIEW
Eleni Sapountzi, Mohamed Braiek, Jean-François Chateaux, Nicole Jaffrezic-Renault, Florence Lagarde
Electrospinning has emerged as a very powerful method combining efficiency, versatility and low cost to elaborate scalable ordered and complex nanofibrous assemblies from a rich variety of polymers. Electrospun nanofibers have demonstrated high potential for a wide spectrum of applications, including drug delivery, tissue engineering, energy conversion and storage, or physical and chemical sensors. The number of works related to biosensing devices integrating electrospun nanofibers has also increased substantially over the last decade...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28810994/comparison-of-point-of-care-versus-laboratory-troponin-testing-in-an-emergency-department-setting
#11
Michael Juliano, Courtney Wason
BACKGROUND: There have been concerns regarding troponin results accuracy between point-of-care (POC) testing preformed in an emergency department (ED) setting and laboratory testing. The purpose of this study was to compare the results of cardiac troponin I testing as concerns POC testing and laboratory analysis as a way to show that these results are interchangeable. METHODS: A retrospective chart review was performed from October 2012 through September 2013 to identify all patients who presented to the ED that received both a POC and laboratory troponin associated with the same blood draw...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28809203/clinical-simulation-a-protocol-for-evaluation-of-mobile-technology
#12
Carey Mather, Sanne Jensen, Elizabeth Cummings
For mobile technology to be accepted at point of care in healthcare environments there is a need to demonstrate benefits whilst ameliorating the risks and challenges. To provide a standardised approach to evaluation of mobile technology a simulation protocol was developed to provide guidance for its use in healthcare environments. Simulated conditions provide the opportunity to assess intended and unintended consequences and identify potential workarounds when using technology. The protocol can also be used to demonstrate the importance of the development of digital professionalism by end-users prior to students entering the clinical practice setting...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28798855/printed-microfluidic-filter-for-heparinized-blood
#13
Stanley E R Bilatto, Nouran Y Adly, Daniel S Correa, Bernhard Wolfrum, Andreas Offenhäusser, Alexey Yakushenko
A simple lab-on-a-chip method for blood plasma separation was developed by combining stereolithographic 3D printing with inkjet printing, creating a completely sealed microfluidic device. In some approaches, one dilutes the blood sample before separation, reducing the concentration of a target analyte and increasing a contamination risk. In this work, a single drop (8 μl) of heparinized whole blood could be efficiently filtered using a capillary effect without any external driving forces and without dilution...
May 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28790334/single-microfluidic-electrochemical-sensor-system-for-simultaneous-multi-pulmonary-hypertension-biomarker-analyses
#14
GeonHui Lee, JuKyung Lee, JeongHoon Kim, Hak Soo Choi, Jonghan Kim, SangHoon Lee, HeaYeon Lee
Miniaturized microfluidic biosensors have recently been advanced for portable point-of-care diagnostics by integrating lab-on-a-chip technology and electrochemical analysis. However, the design of a small, integrated, and reliable biosensor for multiple and simultaneous electrochemical analyses in a single device remains a challenge. Here, we present a simultaneous microfluidic electrochemical biosensing system to detect multiple biomarkers of pulmonary hypertension diseases in a single device. The miniaturized biosensor, which is composed of five chambers, is precisely and individually controlled using in-house-built pneumatic microvalves to manipulate the flow pathway...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782924/high-signal-to-background-ratio-detection-of-cancer-cells-with-activatable-strategy-based-on-target-induced-self-assembly-of-split-aptamers
#15
Baoyin Yuan, Yuqiong Sun, Qiuping Guo, Jin Huang, Xiaohai Yang, Yuanyuan Chen, Xiaohong Wen, Xiangxian Meng, Jianbo Liu, Kemin Wang
Highly sensitive detection of cancer cells with high signal-to-background ratio (SBR) is still urgently needed. Here, a self-assembling activatable probe (SAAP) based on split aptamers was developed to meet this purpose. The SAAP is formed with quenched fluorescence; only when target cells are present would the split aptamers self-assemble together and thus activate fluorescence by intramolecular and intermolecular fluorescence quenching strategies. As proof of concept, a split aptamer pair stemming from an intact aptamer, ZY11, developed by our lab was selected to construct SAAP...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28766343/isothermal-point-mutation-detection-toward-a-first-pass-screening-strategy-for-multidrug-resistant-tuberculosis
#16
Benjamin Y C Ng, Eugene J H Wee, Kyra Woods, Will Anderson, Fiach Antaw, Hennes Z H Tsang, Nicholas P West, Matt Trau
Point mutations in DNA are useful biomarkers that can provide critical classification of disease for accurate diagnosis and to inform clinical decisions. Conventional approaches to detect point mutations are usually based on technologies such as real-time polymerase chain reaction (PCR) or DNA sequencing, which are typically slow and require expensive lab-based equipment. While rapid isothermal strategies such as recombinase polymerase amplification (RPA) have been proposed, they tend to suffer from poor specificity in discriminating point mutations...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28751783/a-facile-and-flexible-method-for-on-demand-directional-speed-tunability-in-the-miniaturised-lab-on-a-disc
#17
Ming K Tan, Ariba Siddiqi, Leslie Y Yeo
The Miniaturised Lab-on-a-Disc (miniLOAD) platform, which utilises surface acoustic waves (SAWs) to drive the rotation of thin millimeter-scale discs on which microchannels can be fabricated and hence microfluidic operations can be performed, offers the possibility of miniaturising its larger counterpart, the Lab-on-a-CD, for true portability in point-of-care applications. A significant limitation of the original miniLOAD concept, however, is that it does not allow for flexible control over the disc rotation direction and speed without manual adjustment of the disc's position, or the use of multiple devices to alter the SAW frequency...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28750335/ironphone-mobile-device-coupled-point-of-care-diagnostics-for-assessment-of-iron-status-by-quantification-of-serum-ferritin
#18
Balaji Srinivasan, Dakota O'Dell, Julia L Finkelstein, Seoho Lee, David Erickson, Saurabh Mehta
Iron deficiency (ID) is an urgent public health problem that has devastating effects on maternal and child health. However, due to poor access and affordability, screening and diagnosis for ID is often limited to proxy hemoglobin measurements alone. Here, we report the development and validation of ironPhone, a mobile-device coupled portable diagnostics for quantification of serum ferritin concentrations, an iron status biomarker, within a few minutes, from a drop of fingerprick blood. The ironPhone diagnostic platform comprises of a smartphone accessory, an app, and a disposable lateral flow immunoassay test strip to quantify serum ferritin...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28748430/inicu-integrated-neonatal-care-unit-capturing-neonatal-journey-in-an-intelligent-data-way
#19
Harpreet Singh, Gautam Yadav, Raghuram Mallaiah, Preetha Joshi, Vinay Joshi, Ravneet Kaur, Suneyna Bansal, Samir K Brahmachari
Neonatal period represents first 28 days of life, which is the most vulnerable time for a child's survival especially for the preterm babies. High neonatal mortality is a prominent and persistent problem across the globe. Non-availability of trained staff and infrastructure are the major recognized hurdles in the quality care of these neonates. Hourly progress growth charts and reports are still maintained manually by nurses along with continuous calculation of drug dosage and nutrition as per the changing weight of the baby...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28730699/elevated-cardiac-troponin-t-in-cirrhotic-patients-with-emergency-care-admissions-is-associated-with-mortality
#20
Mayada Elnegouly, Katrin Umgelter, Wajima Safi, Alexander Hapfelmeier, Roland M Schmid, Andreas Umgelter
BACKGROUND & AIMS: Mortality of cirrhotic patients after emergency care admission is high and prognostic factors can help in prioritizing patients. The aim of our study was to assess the association between levels of cardiac Troponin T (cTnT) and one-year mortality in patients with liver cirrhosis without known cardiac disease, who were admitted to the emergency department (ED). METHODS: All patients with cirrhosis presented to the ED from October 2009 until August 2015 who had an initial cTnT value measured with the first lab-panel were retrospectively analyzed with a follow-up of 365 days...
July 20, 2017: Journal of Gastroenterology and Hepatology
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