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https://www.readbyqxmd.com/read/29308452/the-role-of-microsystems-integration-towards-point-of-care-clozapine-treatment-monitoring-in-schizophrenia
#1
Thomas E Winkler, Florence O Stevenson, Eunkyoung Kim, Mijeong Kang, Gregory F Payne, Deanna L Kelly, Reza Ghodssi
We present a perspective on microsystems integration aspects for concurrent cellular and molecular sensing in a lab-on-a-chip device. While of interest for a range of applications, very few - narrowly focused - examples of such devices can be found in the literature. Here, we approach the challenge from a systems level, considering sensor integration both in parallel and in series. Our study is specifically geared toward schizophrenia treatment, where concurrent blood monitoring of the antipsychotic clozapine and white blood cells could lead to improved treatment outcomes...
March 2018: IEEE Sensors Letters
https://www.readbyqxmd.com/read/29305096/automated-real-time-detection-of-drug-resistant-mycobacterium-tuberculosis-on-a-lab-on-a-disc-by-recombinase-polymerase-amplification
#2
I L G Law, J F C Loo, H C Kwok, H Y Yeung, C C H Leung, M Hui, S Y Wu, H S Chan, Y W Kwan, H P Ho, S K Kong
With the emergence of multi- and extensive-drug (MDR/XDR) resistant Mycobacterium tuberculosis (M. tb), tuberculosis (TB) persists as one of the world's leading causes of death. Recently, isothermal DNA amplification methods received much attention due to their ease of translation onto portable point-of-care (POC) devices for TB diagnosis. In this study, we aimed to devise a simple yet robust detection method for M. tb. Amongst the numerous up-and-coming isothermal techniques, Recombinase Polymerase Amplification (RPA) was chosen for a real-time detection of TB with or without MDR...
January 2, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29302660/acoustofluidic-devices-controlled-by-cell-phones
#3
Hunter Bachman, Po-Hsun Huang, Shuaiguo Zhao, Shujie Yang, Peiran Zhang, Hai Fu, Tony Jun Huang
Acoustofluidic devices have continuously demonstrated their potential to impact medical diagnostics and lab-on-a-chip applications. To bring these technologies to real-world applications, they must be made more accessible to end users. Herein, we report on the effort to provide an easy-to-use and portable system for controlling sharp-edge-based acoustofluidic devices. With the use of a cell phone and a modified Bluetooth® speaker, on-demand and hands-free pumping and mixing are achieved. Additionally, a novel design for a sharp-edge-based acoustofluidic device is proposed that combines both pumping and mixing functions into a single device, thus removing the need for external equipment typically needed to accomplish these two tasks...
January 5, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29289308/creasensor-simple-technology-for-creatinine-detection-in-plasma
#4
Francesco Dal Dosso, Deborah Decrop, Elena Pérez-Ruiz, Devin Daems, Hannah Agten, Osamah Al-Ghezi, Olivier Bollen, Jolien Breukers, Florian De Rop, Maria Katsafadou, Jens Lepoudre, Linye Lyu, Pieter Piron, Robbe Saesen, Shoera Sels, Rani Soenen, Ellen Staljanssens, Jehan Taraporewalla, Tadej Kokalj, Dragana Spasic, Jeroen Lammertyn
The lab-on-a-chip (LOC) field has witnessed an excess of new technology concepts, especially for the point-of-care (POC) applications. However, only few concepts reached the POC market often because of challenging integration with pumping and detection systems as well as with complex biological assays. Recently, a new technology termed SIMPLE was introduced as a promising POC platform due to its features of being self-powered, autonomous in liquid manipulations, cost-effective and amenable to mass production...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29258285/point-of-care-diagnostics-recent-advances-and-trends
#5
EDITORIAL
Sandeep Kumar Vashist
Recent years have witnessed tremendous advances in point-of-care diagnostics (POCD), which are a result of continuous developments in biosensors, microfluidic, bioanalytical platforms, assay formats, lab-on-a-chip technologies, and complementary technologies. This special issue targets the critical advances in POCD and provides guided insights and directions for future research.
December 18, 2017: Biosensors
https://www.readbyqxmd.com/read/29226448/better-measurement-for-performance-improvement-in-low-and-middle-income-countries-the-primary-health-care-performance-initiative-phcpi-experience-of-conceptual-framework-development-and-indicator-selection
#6
Jeremy Veillard, Krycia Cowling, Asaf Bitton, Hannah Ratcliffe, Meredith Kimball, Shannon Barkley, Laure Mercereau, Ethan Wong, Chelsea Taylor, Lisa R Hirschhorn, Hong Wang
Policy Points: Strengthening accountability through better measurement and reporting is vital to ensure progress in improving quality primary health care (PHC) systems and achieving universal health coverage (UHC). The Primary Health Care Performance Initiative (PHCPI) provides national decision makers and global stakeholders with opportunities to benchmark and accelerate performance improvement through better performance measurement. Results from the initial PHC performance assessments in low- and middle-income countries (LMICs) are helping guide PHC reforms and investments and improve the PHCPI's instruments and indicators...
December 2017: Milbank Quarterly
https://www.readbyqxmd.com/read/29204476/data-documenting-the-performance-of-the-pt-inr-line-correction-method-for-reconciling-inr-discrepancies-between-central-laboratory-coagulation-analyzers-using-different-thromboplastins-during-the-evaluation-of-a-portable-coagulometer
#7
Wendy S Baker, Kathleen J Albright, Heidi Spratt, Megan Berman, Peggy A Mann, Jaime Unabia, John R Petersen
The data presented here was produced as part of an evaluation of the performance of the CoaguChek XS point-of-care coagulation analyzer, which is discussed in the research article "POCT PT INR - Is it adequate for Patient Care? A Comparison of the Roche Coaguchek XS vs. Stago Star vs. Siemens BCS in Patients Routinely Seen in an Anticoagulation Clinic" (Baker et al., in press) [1]. An effort to reconcile discrepancies in the patient INR result distributions from different central lab instruments (Stago Star and Siemens BCS) with the PT/INR line method is described (Poller et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29199733/a-robust-portable-and-backflow-free-micromixing-device-based-on-both-capillary-and-vacuum-driven-flows
#8
Yaguang Zhai, Anyang Wang, Domin Koh, Philip Schneider, Kwang W Oh
In capillary- or vacuum-driven microfluidics, surge backflow events are common when merging or pumping two similar or dissimilar liquids together if a pressure difference exists between them. In this work, a robust, portable micromixing device that is insensitive to backflow was designed, fabricated and characterised. A capillary-driven pressure balancing bypass connected between two inlet ports diminished the initial pressure difference caused by capillarity and gravity present in each liquid at the two inlet ports...
December 4, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29190713/operational-evaluation-of-rapid-diagnostic-testing-for-ebola-virus-disease-in-guinean-laboratories
#9
Amanda VanSteelandt, Josephine Aho, Kristyn Franklin, Jacques Likofata, Jean Baptiste Kamgang, Sakoba Keita, Lamine Koivogui, N'Faly Magassouba, Lise D Martel, Anicet George Dahourou
BACKGROUND: Rapid Diagnostic Tests (RDTs) for Ebola Virus Disease (EVD) at the point of care have the potential to increase access and acceptability of EVD testing and the speed of patient isolation and secure burials for suspect cases. A pilot program for EVD RDTs in high risk areas of Guinea was introduced in October 2015. This paper presents concordance data between EVD RDTs and PCR testing in the field as well as an assessment of the acceptability, feasibility, and quality assurance of the RDT program...
2017: PloS One
https://www.readbyqxmd.com/read/29189595/fast-and-sensitive-automated-point-of-care-urine-dips
#10
Laurie Malia, Kaitlin Strumph, Sharon Smith, John Brancato, Stephanie T Johnson, Henry Chicaiza
OBJECTIVE: Point-of-care (POC) urine dipstick is a highly used test in the pediatric emergency department (PED) owing to its fast turn-around time and inexpensive cost. Past studies have shown hand-held urine dipsticks and automated urinalysis in children younger than 48 months to be sensitive predictors for urinary tract infection (UTI). It is hypothesized that POC dip testing is as accurate as laboratory urinalysis in the diagnosis of UTI. METHODS: A retrospective chart review was conducted on patients (aged birth through 18 years) presenting to a PED between January 2015 and December 2015...
November 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29182641/treatment-eligibility-and-retention-in-clinical-hiv-care-a-regression-discontinuity-study-in-south-africa
#11
Jacob Bor, Matthew P Fox, Sydney Rosen, Atheendar Venkataramani, Frank Tanser, Deenan Pillay, Till Bärnighausen
BACKGROUND: Loss to follow-up is high among HIV patients not yet receiving antiretroviral therapy (ART). Clinical trials have demonstrated the clinical efficacy of early ART; however, these trials may miss an important real-world consequence of providing ART at diagnosis: its impact on retention in care. METHODS AND FINDINGS: We examined the effect of immediate (versus deferred) ART on retention in care using a regression discontinuity design. The analysis included all patients (N = 11,306) entering clinical HIV care with a first CD4 count between 12 August 2011 and 31 December 2012 in a public-sector HIV care and treatment program in rural South Africa...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29134742/innovative-technologies-for-point-of-care-testing-of-viral-hepatitis%C3%A2-in-low-resource-and-decentralized-settings
#12
Léa Duchesne, Karine Lacombe
According to the Global Burden of Diseases, chronic viral hepatitis B and C are one of the most challenging global health conditions that rank among the first causes of morbidity and mortality worldwide. Low and middle income countries are particularly affected by the health burden associated with HBV or HCV infection. One major gap in efficiently addressing the issue of viral hepatitis is universal screening. However, the costs and chronic lack of human resources for using traditional screening strategies based on serology and molecular biology preclude any scaling-up...
November 13, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29134112/a-review-on-zno-based-electrical-biosensors-for-cardiac-biomarker-detection
#13
REVIEW
Nandhinee R Shanmugam, Sriram Muthukumar, Shalini Prasad
Over the past few decades zinc oxide (ZnO)-based thin films and nanostructures have shown unprecedented performance in a wide range of applications. In particular, owing to high isoelectric point, biocompatibility and other multifunctional characteristics, ZnO has extensively been studied as a transduction material for biosensor development. The fascinating properties of ZnO help retain biological activity of the immobilized biomolecule and help in achieving enhanced sensing performance. As a consequence of recent advancements in this multidisciplinary field, diagnostic biosensors are expanding beyond traditional clinical labs to point-of-care and home settings...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29131592/a-paper-plastic-hybrid-microfluidic-device-for-smartphone-based-colorimetric-analysis-of-urine
#14
M Jalal Uddin, Gyeong Jun Jin, Joon Sub Shim
In this work, a disposable paper-plastic hybrid microfluidic lab-on-a-chip (LOC) has been developed and successfully applied for the colorimetric measurement of urine by the smartphone-based optical platform using an "UrineAnalysis" Android app. The developed device was cost-effectively implemented as a stand-alone hybrid LOC by incorporating the paper-based conventional reagent test strip inside the plastic-based LOC microchannel. The LOC device quantitatively investigated the small volume (40 µL) of urine analytes for the colorimetric reaction of glucose, protein, pH and red blood cell (RBC) in integration with the finger-actuating micro pump...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29129601/on-chip-signal-amplification-of-magnetic-bead-based-immunoassay-by-aviating-magnetic-bead-chains
#15
Uddin M Jalal, Gyeong Jun Jin, Kyu Shik Eom, Min Ho Kim, Joon S Shim
In this work, a Lab-on-a-Chip (LOC) platform is used to electromagnetically actuate magnetic bead chains for an enhanced immunoassay. Custom-made electromagnets generate a magnetic field to form, rotate, lift and lower the magnetic bead chains (MBCs). The cost-effective, disposable LOC platform was made with a polymer substrate and an on-chip electrochemical sensor patterned via the screen-printing process. The movement of the MBCs is controlled to improve the electrochemical signal up to 230% when detecting beta-type human chorionic gonadotropin (β-hCG)...
November 6, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29127692/coagulation-measurement-from-whole-blood-using-vibrating-optical-fiber-in-a-disposable-cartridge
#16
Yusuf Samet Yaraş, Ali Bars Gündüz, Gökhan Sağlam, Selim Ölçer, Fehmi Civitçi, İbrahim Baris, Göksenin Yaralioğlu, Hakan Urey
In clinics, blood coagulation time measurements are performed using mechanical measurements with blood plasma. Such measurements are challenging to do in a lab-on-a-chip (LoC) system using a small volume of whole blood. Existing LoC systems use indirect measurement principles employing optical or electrochemical methods. We developed an LoC system using mechanical measurements with a small volume of whole blood without requiring sample preparation. The measurement is performed in a microfluidic channel where two fibers are placed inline with a small gap in between...
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29095669/the-anatomy-of-a-nonfaradaic-electrochemical-biosensor
#17
Hunter Stevenson, Nandhinee Radha Shanmugam, Anjan Paneer Selvam, Shalini Prasad
Point-of-care (POC) testing has revolutionized diagnostic healthcare, bringing medical results directly and immediately to the patient. With faster diagnostics, more immediate clinical management decisions can be made. POC tests most often use a dipstick or swab format to detect the presence of a pathogen, disease, or other relevant biomarker. In these formats, the POC tests eliminate the need for complex lab equipment and trained personnel to collect, process, and analyze sample data for simple diagnostics...
November 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29089550/microgel-assisted-lab-on-fiber-optrode
#18
A Aliberti, A Ricciardi, M Giaquinto, A Micco, E Bobeico, V La Ferrara, M Ruvo, A Cutolo, A Cusano
Precision medicine is continuously demanding for novel point of care systems, potentially exploitable also for in-vivo analysis. Biosensing probes based on Lab-On-Fiber Technology have been recently developed to meet these challenges. However, devices exploiting standard label-free approaches (based on ligand/target molecule interaction) suffer from low sensitivity in all cases where the detection of small molecules at low concentrations is needed. Here we report on a platform developed through the combination of Lab-On-Fiber probes with microgels, which are directly integrated onto the resonant plasmonic nanostructure realized on the fiber tip...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29077390/lab-on-chip-devices-gaining-ground-losing-size
#19
Veronica C Romao, Sofia A M Martins, Jose Germano, Filipe A Cardoso, Susana Cardoso, Paulo P Freitas
Portable analytical devices are notably gaining relevance in the panorama of urgent testing. Such devices have the potential to play an important role as easy-to-handle tools in critical situations. Epidemic infectious disease agents (e.g., Ebola virus, Coronavirus, Zika virus) could be controlled more easily by testing travelers on-site at the country borders to prevent outbreaks from spreading. The increasing incidence of hospital-acquired infections caused by antibiotic resistant pathogens could be minimized by point-of-care microbial analysis as well as rapid screening tests of bacteria resistance...
October 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29068663/portable-gmr-handheld-platform-for-the-detection-of-influenza-a-virus
#20
Kai Wu, Todd Klein, Venkatramana D Krishna, Diqing Su, Andres M Perez, Jian-Ping Wang
Influenza A virus (IAV) is a common respiratory pathogen infecting many hosts including humans, pigs (swine influenza virus or SIV), and birds (avian influenza virus or AIV). Monitoring swine and avian influenza viruses in the wild, farms, and live poultry markets is of great significance for human and veterinary public health. A portable, sensitive, and quantitative immunoassay device will be of high demand especially in the rural and resource-limited areas. We report herein our Z-Lab point-of-care (POC) device for sensitive and specific detection of swine influenza viruses with minimum sample handling and laboratory skill requirements...
October 25, 2017: ACS Sensors
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