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https://www.readbyqxmd.com/read/29790491/advancements-in-microfluidic-technologies-for-isolation-and-early-detection-of-circulating-cancer-related-biomarkers
#1
REVIEW
Ankit Rana, Yuqian Zhang, Leyla Esfandiari
Early stage detection of cancer is essential for the improved long-term survival of patients. Currently, costly, extensively complex and invasive procedures, such as surgical tissue biopsies, are used for cancer screening. Thus, over the past few decades, advancements in microfluidics and lab-on-a-chip approaches have been made to develop minimally invasive and miniaturized platforms to identify and segregate circulating cancer biomarkers such as exosomes, circulating tumor cells (CTCs) and cell-free DNA (cfDNA) from body fluids...
May 23, 2018: Analyst
https://www.readbyqxmd.com/read/29783081/recent-technological-advancements-in-tuberculosis-diagnostics-a-review
#2
REVIEW
Shagun Gupta, Vipan Kakkar
Early diagnosis and on-time effective treatment are indispensable for Tuberculosis (TB) control - a life threatening infectious communicable disease. The conventional techniques for diagnosing TB normally take two to three weeks. This delay in diagnosis and further increase in detection complexity due to the emerging risks of XDR-TB (Extensively drug Resistant-TB) and MDR-TB (Multidrug Resistant-TB) are evoking interest of researchers in the field of developing rapid TB detection techniques such as biosensing and other point-of-care (POC) techniques...
May 11, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29766658/ampli-a-construction-set-for-paperfluidic-systems
#3
Elizabeth A Phillips, Anna K Young, Nikolas Albarran, Jonah Butler, Kaira Lujan, Kimberly Hamad-Schifferli, Jose Gomez-Marquez
The design and fabrication of reconfigurable, modular paperfluidics driven by a prefabricated reusable block library, asynchronous modular paperfluidic linear instrument-free (Ampli) block, are reported. The blocks are inspired by the plug-and-play modularity of electronic breadboards that lower prototyping barriers in circuit design. The resulting biochemical breadboard is a paperfluidic construction set that can be functionalized with chemical, biological, and electrical elements. Ampli blocks can form standard paperfluidic devices without any external instrumentation...
May 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29755211/microfluidic-diatomite-analytical-devices-for-illicit-drug-sensing-with-ppb-level-sensitivity
#4
Xianming Kong, Xinyuan Chong, Kenny Squire, Alan X Wang
The escalating research interests in porous media microfluidics, such as microfluidic paper-based analytical devices, have fostered a new spectrum of biomedical devices for point-of-care (POC) diagnosis and biosensing. In this paper, we report microfluidic diatomite analytical devices (μDADs), which consist of highly porous photonic crystal biosilica channels, as an innovative lab-on-a-chip platform to detect illicit drugs. The μDADs in this work are fabricated by spin-coating and tape-stripping diatomaceous earth on regular glass slides with cross section of 400×30µm2 ...
April 15, 2018: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/29745370/moo-3-nano-si-heterostructure-based-highly-sensitive-and-acetone-selective-sensor-prototype-a-key-to-non-invasive-detection-of-diabetes
#5
Priyanka Dwivedi, Saakshi Dhanekar, Samaresh Das
This paper presents the development of an extremely sensitive and selective acetone sensor prototype which can be used as a platform for non-invasive diabetes detection through exhaled human breath. The miniaturized sensors were produced in high yield with the use of standard microfabrication processes. The sensors were based on a heterostructure composed of MoO3 and nano-porous silicon (NPS). Features like acetone selective, enhanced sensor response and 0.5 ppm detection limit were observed upon introduction of MoO3 on the NPS...
July 6, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29744764/analytical-performance-of-a-platform-for-point-of-care-crp-testing-in-adults-consulting-for-lower-respiratory-tract-infection-in-primary-care
#6
Veerle Matheeussen, Viviane Van Hoof, Katherine Loens, Christine Lammens, Anouk Vanderstraeten, Samuel Coenen, Chris C Butler, Paul Little, Theo J M Verheij, Herman Goossens, Margareta Ieven
C-reactive protein (CRP) is a biomarker widely used for disease severity assessment and treatment of inflammatory conditions. Point-of-care testing (POCT) devices should ideally be rapid and provide similar results to standard tests done in laboratories. Two thousand nine hundred twenty-two serum samples were obtained from adult patients presenting to primary care with symptoms of lower respiratory infection in a European diagnostic study. The analytic performance of the CRP QuikRead POCT device (Orion Diagnostica) was evaluated by comparing results with a central laboratory method (Dimension Vista, Siemens), with both tests performed in a laboratory setting...
May 10, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29733891/-connecting-worlds-a-view-on-microfluidics-for-a-wider-application
#7
REVIEW
Ana C Fernandes, Krist V Gernaey, Ulrich Krühne
From its birth, microfluidics has been referenced as a revolutionary technology and the solution to long standing technological and sociological issues, such as detection of dilute compounds and personalized healthcare. Microfluidics has for example been envisioned as: (1) being capable of miniaturizing industrial production plants, thereby increasing their automation and operational safety at low cost; (2) being able to identify rare diseases by running bioanalytics directly on the patient's skin; (3) allowing health diagnostics in point-of-care sites through cheap lab-on-a-chip devices...
May 4, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29727750/discrimination-of-single-nucleotide-mismatches-using-a-scalable-flexible-and-transparent-three-dimensional-nanostructure-based-plasmonic-mirna-sensor-with-high-sensitivity
#8
Hee-Kyung Na, Jung-Sub Wi, Hye Young Son, Jong G Ok, Yong-Min Huh, Tae Geol Lee
Localized surface plasmon resonance (LSPR) biosensors have attracted much interest due to their capacity for multiplexing, miniaturization, and high performance, which offers the potential for their integration into lab-on-a-chip platforms for point-of-care (POC) diagnostics. The need for microRNA (miRNA)-sensing platforms is particularly urgent because miRNAs are key regulators and biomarkers in numerous pathological processes and diseases. Unfortunately, however, development of such miRNA-sensing platforms has not yet been achieved...
April 22, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29677997/the-perspective-of-nurses-on-nursing-information-system-a-case-study-in-a-developing-country
#9
Masoumeh Sarbaz, Khalil Kimiafar, Elham Nazari
The purpose of this study was to investigate the effect of nursing information system (NIS) on clinical performance from the perspective of nurses in an academic hospital affiliated to Mashhad University of Medical Sciences in Iran. This descriptive cross-sectional study was conducted in 2016. We collected data targeting nurses with over three years' experience in using the NIS (120 nurses). NIS had caused improvement in "accuracy the consistency of drug, lab tests and radiology requests", "increasing the speed of the automated extracting of minimum data set for decision making and care trends" with the means of 4...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29658031/fully-automated-on-site-isolation-of-cfdna-from-whole-blood-for-cancer-therapy-monitoring
#10
Chi-Ju Kim, Juhee Park, Vijaya Sunkara, Tae-Hyeong Kim, Yongjin Lee, Kyusang Lee, Mi-Hyun Kim, Yoon-Kyoung Cho
The potential utility of circulating tumour DNA (ctDNA) in patient blood for cancer diagnostics and real-time monitoring of disease progression is highly recognized. However, the lack of automated and efficient methods for cell-free DNA (cfDNA) isolation from peripheral blood has remained a challenge for broader acceptance of liquid biopsy in general clinical settings. Here, we demonstrate a lab-on-a-disc system equipped with newly developed, electromagnetically actuated, and reversible diaphragm valves that allows fully automated and rapid (<30 min) isolation of cfDNA from whole blood (>3 ml) to achieve high detection sensitivity by minimizing the degradation of fragile ctDNA as well as contamination of wild-type DNA from abundant blood cells...
May 1, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29619901/inflammatory-biomarkers-to-guide-diagnostic-and-therapeutic-decisions-in-children-presenting-with-fever-without-apparent-source
#11
Giulia Trippella, Luisa Galli, Maurizio de Martino, Elena Chiappini
A systematic review of literature from 2011 to 2016 was performed, in order to evaluate the diagnostic performance of inflammatory biomarkers in children with fever without apparent source and their usefulness in clinical decision-making. Data source was the Pubmed database. Thirteen studies were included, analysing the following biomarkers: erythrocyte sedimentation rate, white blood count, absolute neutrophil count, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) and the Lab-score (a combination of CRP, PCT and urine dipstick)...
April 5, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29605138/equipment-free-nucleic-acid-extraction-and-amplification-on-a-simple-paper-disc-for-point-of-care-diagnosis-of-rotavirus-a
#12
Xin Ye, Jin Xu, Lijuan Lu, Xinxin Li, Xueen Fang, Jilie Kong
The use of paper-based methods for clinical diagnostics is a rapidly expanding research topic attracting a great deal of interest. Some groups have attempted to realize an integrated nucleic acid test on a single microfluidic paper chip, including extraction, amplification, and readout functions. However, these studies were not able to overcome complex modification and fabrication requirements, long turn-around times, or the need for sophisticated equipment like pumps, thermal cyclers, or centrifuges. Here, we report an extremely simple paper-based test for the point-of-care diagnosis of rotavirus A, one of the most common pathogens that causes pediatric gastroenteritis...
August 14, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29544519/noninvasive-hematocrit-assessment-for-cardiovascular-magnetic-resonance-extracellular-volume-quantification-using-a-point-of-care-device-and-synthetic-derivation
#13
Sean Robison, Gauri Rani Karur, Rachel M Wald, Paaladinesh Thavendiranathan, Andrew M Crean, Kate Hanneman
BACKGROUND: Calculation of cardiovascular magnetic resonance (CMR) extracellular volume (ECV) requires input of hematocrit, which may not be readily available. The purpose of this study was to evaluate the diagnostic accuracy of ECV calculated using various noninvasive measures of hematocrit compared to ECV calculated with input of laboratory hematocrit as the reference standard. METHODS: One hundred twenty three subjects (47.7 ± 14.1 years; 42% male) were prospectively recruited for CMR T1 mapping between August 2016 and April 2017...
March 15, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29517791/an-ultrafast-one-step-assay-for-the-visual-detection-of-rna-virus
#14
Cuiping Ma, Hao Jing, Pansong Zhang, Lingzhi Han, Meiling Zhang, Fuxin Wang, Shuyan Niu, Chao Shi
A one-step, rapid, and visual method was developed for the detection of RNA viruses and a few copies of the Zika RNA virus were directly detected within 25 min by naked-eye observation. This method will prove to be promising for point-of-care testing in out-of-lab and inconvenient settings.
March 28, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29511216/direct-detection-of-unamplified-pathogen-rna-in-blood-lysate-using-an-integrated-lab-in-a-stick-device-and-ultrabright-sers-nanorattles
#15
Hoan T Ngo, Elizabeth Freedman, Ren Abelard Odion, Pietro Strobbia, Agampodi Swarnapali De Silva Indrasekara, Priya Vohra, Steve M Taylor, Tuan Vo-Dinh
Direct detection of genetic biomarkers in body fluid lysate without target amplification will revolutionize nucleic acid-based diagnostics. However, the low concentration of target sequences makes this goal challenging. We report a method for direct detection of pathogen RNA in blood lysate using a bioassay using surface-enhanced Raman spectroscopy (SERS)-based detection integrated in a "lab-in-a-stick" portable device. Two levels of signal enhancement were employed to achieve the sensitivity required for direct detection...
March 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29507828/human-anti-hiv-igm-detection-by-the-oraquick-advance-%C3%A2-rapid-hiv-1-2-antibody-test
#16
Geraldine Guillon, Graham Yearwood, Casey Snipes, Daniel Boschi, Michael R Reed
The Centers for Disease Control and Prevention (CDC) and many public health jurisdictions continue to advocate for the most sensitive rapid HIV test that is available. Currently, the recommendation is to utilize tests that can detect HIV infection biomarkers within 30 days of infection, when initial immune responses are mounted. The infected patient's IgM response is often used to detect acute infection within a 20-25 days window after infection. This requirement applies to lab-based testing with automated analyzers and rapid, point of care (POC) testing used for screening in a non-clinical setting...
2018: PeerJ
https://www.readbyqxmd.com/read/29480958/controllable-assembly-of-enzymes-for-multiplexed-lab-on-a-chip-bioassays-with-a-tunable-detection-range
#17
Yunlei Xianyu, Jing Wu, Yiping Chen, Wenshu Zheng, Mengxia Xie, Xingyu Jiang
Multiplexed analysis of molecules with different concentrations requires assays with a tunable detection range. A strategy is outlined that uses click chemistry to assemble horseradish peroxidase in a controlled fashion to generate enzyme assemblies as probes for multiplexed bioassays. This controllable assembly of enzymes on detection antibodies allows for lab-on-a-chip immunoassays with a tunable detection range from pg mL-1 to μg mL-1 . Simultaneous, multiplexed bioassays of clinically relevant inflammatory biomarkers in serum are demonstrated in one lab-on-a-chip format, with a limit of detection of 0...
February 26, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29447855/rpa-using-a-multiplexed-cartridge-for-low-cost-point-of-care-diagnostics-in-the-field
#18
Luck Tosan Ereku, Ruth E Mackay, Pascal Craw, Angel Naveenathayalan, Thomas Stead, Manorharanehru Branavan, Wamadeva Balachandran
A point of care device utilising Lab-on-a-Chip technologies that is applicable for biological pathogens was designed, fabricated and tested showing sample in to answer out capabilities. The purpose of the design was to develop a cartridge with the capability to perform nucleic acid extraction and purification from a sample using a chitosan membrane at an acidic pH. Waste was stored within the cartridge with the use of sodium polyacrylate to solidify or gelate the sample in a single chamber. Nucleic acid elution was conducted using the RPA amplification reagents (alkaline pH)...
April 15, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29428590/quantitative-and-ultrasensitive-detection-of-multiplex-cardiac-biomarkers-in-lateral-flow-assay-with-core-shell-sers-nanotags
#19
Di Zhang, Li Huang, Bing Liu, Haibin Ni, Liangdong Sun, Enben Su, Hongyuan Chen, Zhongze Gu, Xiangwei Zhao
Rapid and sensitive quantification of multiplex proteins in a wide concentration range is challenging in high throughput analysis. Herein, we proposed a lateral flow assay (LFA) based on core-shell surface enhanced Raman scattering (SERS) nanotags for multiplex and quantitative detection of cardiac biomarkers for the early diagnosis of acute myocardial infarction (AMI). In practice, Raman dyes (RDs) were embedded into the interior-gap of silver core and gold shell nanoparticles (NPs) to form SERS nanotags as labels instead of gold colloids and three test lines were employed in the strip for the detection of three cardiac biomarkers, Myo, cTnI, and CK-MB, respectively...
May 30, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29409776/the-validation-of-simplified-eeg-derived-from-the-bispectral-index-monitor-in-post-cardiac-arrest-patients
#20
Jolien Haesen, Ward Eertmans, Cornelia Genbrugge, Ingrid Meex, Jelle Demeestere, Margot Vander Laenen, Willem Boer, Dieter Mesotten, Jo Dens, Frank Jans, Ludovic Ernon, Cathy De Deyne
AIMS: We aimed to validate retrospectively the accuracy of simplified electroencephalography (EEG) monitoring derived from the bispectral index (BIS) monitor in post-cardiac arrest (CA) patients. METHODS: Successfully resuscitated CA patients were transferred to the Catherization Lab followed by percutaneous coronary intervention when indicated. On arrival at the coronary care unit, bilateral BIS monitoring was started and continued up to 72 h. Raw simplified EEG tracings were extracted from the BIS monitor at a time point coinciding with the registration of standard EEG monitoring...
May 2018: Resuscitation
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