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Point of care labs

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https://www.readbyqxmd.com/read/28102419/towards-encoded-particles-for-highly-multiplexed-colorimetric-point-of-care-autoantibody-detection
#1
Gustav Svedberg, Yunjin Jeong, Hunjong Na, Jisung Jang, Peter Nilsson, Sunghoon Kwon, Jesper Gantelius, Helene Andersson Svahn
Highly multiplexed point of care tests could improve diagnostic accuracy and differential diagnostic capacity in for instance emergency medicine and low resource environments. Available technology platforms for POC biomarker detection are typically simplex or low-plexed, whereas common lab-based microarray systems allow for the simultaneous detection of thousands of DNA or protein biomarkers. In this study, we demonstrate a novel suspension particle array platform that utilizes 900 μm bricks for POC amenable colorimetric biomarker detection with an encoding capacity of over two million...
January 19, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28073898/two-stage-isothermal-enzymatic-amplification-for-concurrent-multiplex-molecular-detection
#2
Jinzhao Song, Changchun Liu, Michael G Mauk, Shelley C Rankin, James B Lok, Robert M Greenberg, Haim H Bau
BACKGROUND: The wide array of pathogens responsible for infectious diseases makes it difficult to identify causative pathogens with single-plex tests. Although multiplex PCR detects multiple targets, it is restricted to centralized laboratories, which delays test results or makes multiplexing unavailable, depriving healthcare providers of critical, real-time information. METHODS: To address the need for point-of-care (POC) highly multiplexed tests, we propose the 2-stage, nested-like, rapid (<40 min) isothermal amplification assay, dubbed rapid amplification (RAMP)...
January 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28050904/paper-based-analytical-biosensor-chip-designed-from-graphene-nanoplatelet-amphiphilic-di-block-co-polymer-composite-for-cortisol-detection-in-human-saliva
#3
Muhammad Khan, Santosh K Misra, Zhen Wang, Enrique A Daza, Aaron Schwartz-Duval, Joseph Kus, Debanjan Pan, Dipanjan Pan
Cortisol has been identified as a biomarker in saliva to monitor psychological stress. In this work, we report label-free paper-based electrical biosensor chip to quantify salivary cortisol at a point-of-care (POC) level. A high specificity of the sensor chip to detect cortisol with detection limit of 3 pg/mL was achieved by conjugating anti-cortisol antibody (anti-CAB) on top of gold (Au) microelectrodes using 3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) - as self-assembled monolayer (SAM) agent...
January 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28048668/tu-ab-202-01-multi-institutional-validation-study-of-commercially-available-deformable-image-registration-software-for-thoracic-images
#4
N Kadoya, Y Nakajima, M Saito, Y Miyabe, M Kurooka, S Kito, M Sasaki, Y Fujita, K Arai, K Tani, M Yagi, A Wakita, N Tohyama, K Jingu
PURPOSE: The purpose of this study was to assess the accuracy of commercially available deformable image registration (DIR) software for thoracic images on multi-institution. Furthermore, we determined the variation in the DIR accuracy among institutions due to different DIR algorithms and DIR procedures. METHODS: Thoracic four-dimensional (4D) CT images of ten patients with esophagus or lung cancer were used. Datasets for these patients were provided by DIR-lab (dir-lab...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28007038/semi-quantitative-method-for-staphylococci-magnetic-detection-in-raw-milk
#5
Carla Margarida Duarte, Carla Carneiro, Susana Cardoso, Paulo Peixeiro Freitas, Ricardo Bexiga
Bovine mastitis is the most costly disease for dairy farmers, hence, control measures to prevent it are crucial for dairy farm sustainability. Staphylococcus aureus is considered a major mastitis pathogen because of its impact on milk quality and low cure rates. Prevention of S. aureus mastitis includes segregation of infected animals, whilst treatment of such animals should be performed for a longer time to improve cure rates. This makes identification of S. aureus infected quarters and animals of significant importance...
December 23, 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27987361/analytical-evaluation-of-point-of-care-procalcitonin-pct-and-clinical-performances-in-an-unselected-population-as-compared-with-central-lab-pct-assay
#6
Anne Marie Dupuy, Quentin Chevrier, Yan Olejnik, Anne Sophie Bargnoux, Stéphanie Badiou, Jean Paul Cristol
No abstract text is available yet for this article.
December 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27958721/fast-size-selective-clog-free-isolation-of-rare-cancer-cells-from-whole-blood-at-a-liquid-liquid-interface
#7
Tae-Hyeong Kim, Minji Lim, Juhee Park, Jung Min Oh, Hyeongeun Kim, Hyunjin Jeong, Sun Ju Lee, Hee Chul Park, Sungmok Jung, Byung Chul Kim, Kyusang Lee, Mi-Hyun Kim, Do Youn Park, Gwang Ha Kim, Yoon-Kyoung Cho
Circulating tumor cells (CTCs) have great potential to provide minimally invasive ways for the early detection of cancer metastasis and for the response monitoring of various cancer treatments. Despite the clinical importance and progress of CTC-based cancer diagnostics, most of the current methods of enriching CTCs are difficult to implement in general hospital settings due to complex and time-consuming protocols. Among existing technologies, size-based isolation methods provide antibody-independent, relatively simple, and high throughput protocols...
December 13, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27897004/identifying-genetic-associations-with-variability-in-metabolic-health-and-blood-count-laboratory-values-diving-into-the-quantitative-traits-by-leveraging-longitudinal-data-from-an-ehr
#8
Shefali S Verma, Anastasia M Lucas, Daniel R Lavage, Joseph B Leader, Raghu Metpally, Sarathbabu Krishnamurthy, Frederick Dewey, Ingrid Borecki, Alexander Lopez, John Overton, John Penn, Jeffrey Reid, Sarah A Pendergrass, Gerda Breitwieser, Marylyn D Ritchie
A wide range of patient health data is recorded in Electronic Health Records (EHR). This data includes diagnosis, surgical procedures, clinical laboratory measurements, and medication information. Together this information reflects the patient's medical history. Many studies have efficiently used this data from the EHR to find associations that are clinically relevant, either by utilizing International Classification of Diseases, version 9 (ICD-9) codes or laboratory measurements, or by designing phenotype algorithms to extract case and control status with accuracy from the EHR...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896755/the-application-of-multiplex-biomarker-techniques-for-improved-stratification-and-treatment-of-schizophrenia-patients
#9
Johann Steiner, Paul C Guest, Hassan Rahmoune, Daniel Martins-de-Souza
In the case of major psychiatric disorders such as schizophrenia, shortcomings in the conversion of scientific discoveries into newer and safer treatment options has led to a loss of confidence and precipitated a crisis for large pharmaceutical companies. This chapter describes how incorporation of multiplex biomarker approaches into the clinical pipeline can lead to better patient characterization, delivery of novel treatment approaches and help to renew efforts in this important area. The development of specific biomarker test panels for disease prediction should facilitate early intervention strategies, which may help to slow disease development or progression...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27810632/satisfaction-and-self-confidence-with-nursing-clinical-simulation-novice-learners-medium-fidelity-and-community-settings
#10
Jaclynn Lubbers, Carol Rossman
BACKGROUND: Simulation is fast becoming a normative pedagogy for a portion of clinical time in undergraduate nursing programs in the U.S. Studies have shown positive outcomes in increasing self-confidence and satisfaction with simulation. The questions remain as to which fidelity of simulation best matches which learners, how early can simulation begin with novice students, and in which contexts can simulation be best used for these early learners. This study was undertaken to find out if novice students were able to demonstrate increased satisfaction and self-confidence with medium fidelity simulation in community based roles, as these students have no knowledge of acute care skills at this point in their learning...
January 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27775960/quality-of-sleep-and-coexistent-psychopathology-have-significant-impact-on-fatigue-burden-in-patients-with-inflammatory-bowel-disease
#11
Jana G Hashash, Claudia Ramos-Rivers, Ada Youk, Wai Kan Chiu, Kyle Duff, Miguel Regueiro, David G Binion, Ioannis Koutroubakis, Ashley Vachon, David Benhayon, Michael A Dunn, Eva M Szigethy
BACKGROUND: Fatigue is common in inflammatory bowel disease (IBD) patients and is associated with factors such as psychopathology, sleep quality, and disease activity. GOAL: To investigate the combined role of all the above factors in the burden of fatigue among IBD patients. STUDY: We conducted an observational study of adult patients enrolled in an IBD clinical research registry at a tertiary care clinic. Fatigue burden was defined by Item 1 of the Short-form IBD Questionnaire (SIBDQ), which is scored on a 7-point Likert scale...
October 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27756517/lab-on-a-chip-technologies-for-genodermatoses-recent-progress-and-future-perspectives
#12
REVIEW
Cui Hongzhou, Guo Shuping, Wang Wenju, Li Li, Wei Lulu, Deng Linjun, Li Jingmin, Ren Xiaoli, Bai Li
In recent years, molecular biology has proven to be a great asset in our understanding of mechanisms in genodermatoses. However, bench to bedside translation research lags far behind. Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Sample preparation, microfluidic reactions, and continuous monitoring systems can be integrated on a small chip. These advantages have attracted attention in various fields of clinical application including diagnosis of inherited skin diseases...
February 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27748042/in-situ-simulation-in-emergency-medicine-moving-beyond-the-simulation-lab
#13
Andrew Petrosoniak, Marc Auerbach, Ambrose H Wong, Christopher M Hicks
In situ simulation (ISS), a point of care training strategy that occurs within the patient care environment involving actual healthcare team members, provides additional benefits to centre-based simulation. ISS can serve several roles within emergency medicine (EM): improves provider/team performance, identifies and mitigates threats to patient safety and improves systems and infrastructure. The effective use of ISS fosters inter-professional team training and a culture of safety essential for high performance EM teams and resilient systems...
October 17, 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/27725740/microfluidics-based-point-of-care-test-for-serodiagnosis-of-lyme-disease
#14
Samiksha Nayak, Archana Sridhara, Rita Melo, Luciana Richer, Natalie H Chee, Jiyoon Kim, Vincent Linder, David Steinmiller, Samuel K Sia, Maria Gomes-Solecki
Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid lab-on-a-chip point of care (POC) assay for the serologic diagnosis of human Lyme disease. Following ELISA screening of 12 candidate antigens, we tested 8 on a microfluidic diagnostic system, called mChip-Ld, using a set of 60 serological samples...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27714026/multiplex-snp-genotyping-in-whole-blood-using-an-integrated-microfluidic-lab-on-a-chip
#15
L Zhang, Q Cai, R S Wiederkehr, M Fauvart, P Fiorini, B Majeed, M Tsukuda, T Matsuno, T Stakenborg
Pharmacogenetics has often been touted as a cornerstone for precision medicine as detailed knowledge of a specific genetic makeup may allow for accurate predictions of a patient's individual drug response. Still, the widespread use of genetic tests is limited as they remain expensive and cumbersome, requiring sophisticated tools and highly trained personnel. In order for pharmacogenetics to reach its full potential, more cost-effective and easily accessible genotyping methods are desired. To meet these challenges, we present a silicon-based integrated microsystem for the detection of multiple single nucleotide polymorphisms (SNPs) directly from human blood...
October 5, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27713988/magnetic-adhesive-based-valves-for-microfluidic-devices-used-in-low-resource-settings
#16
Jason C Harper, Jenna M Andrews, Candice Ben, Andrew C Hunt, Jaclyn K Murton, Bryan D Carson, George D Bachand, Julie A Lovchik, William D Arndt, Melissa R Finley, Thayne L Edwards
Since the introduction of micro total analytical systems (μTASs), significant advances have been made toward development of lab-on-a-chip platforms capable of performing complex biological assays that can revolutionize public health, among other applications. However, use of these platforms in low-resource environments (e.g. developing countries) has yet to be realized as the majority of technologies used to control microfluidic flow rely on off-device hardware with non-negligible size, cost, power requirements and skill/training to operate...
October 18, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27682838/a-non-enzymatic-urine-glucose-sensor-with-2-d-photonic-crystal-hydrogel
#17
Zequn Yan, Min Xue, Qian He, Wei Lu, Zihui Meng, Dan Yan, Lili Qiu, Lijun Zhou, Yingjie Yu
A novel polymerized crystalline colloidal array (PCCA) sensing material for the detection of urine glucose was developed by embedding a two-dimensional (2-D) polystyrene crystalline colloidal array (CCA) in 3-acrylamidophenylboronic acid (3-APBA)-functionalized hydrogel. After adjusting the cross-linker concentration, this material showed significant sensitivity for glucose under lab conditions, the particle spacing of the PCCA changed from 917 to 824 nm (93 nm) within 3 min as the glucose concentration increased from 0 to 10 mM, and the structural color of the PCCA changed from red through orange, to green, and finally, to cyan...
November 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27660018/sample-to-answer-on-molecular-diagnosis-of-bacterial-infection-using-integrated-lab-on-a-disc
#18
J F C Loo, H C Kwok, C C H Leung, S Y Wu, I L G Law, Y K Cheung, Y Y Cheung, M L Chin, P Kwan, M Hui, S K Kong, H P Ho
Sepsis by bacterial infection causes high mortality in patients in intensive care unit (ICU). Rapid identification of bacterial infection is essential to ensure early appropriate administration of antibiotics to save lives of patients, yet the present benchtop molecular diagnosis is time-consuming and labor-intensive, which limits the treatment efficiency especially when the number of samples to be tested is extensive. Therefore, we hereby report a microfluidic platform lab-on-a-disc (LOAD) to provide a sample-to-answer solution...
September 2, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27602780/nanoscale-electrochemical-sensor-arrays-redox-cycling-amplification-in-dual-electrode-systems
#19
Bernhard Wolfrum, Enno Kätelhön, Alexey Yakushenko, Kay J Krause, Nouran Adly, Martin Hüske, Philipp Rinklin
Micro- and nanofabriation technologies have a tremendous potential for the development of powerful sensor array platforms for electrochemical detection. The ability to integrate electrochemical sensor arrays with microfluidic devices nowadays provides possibilities for advanced lab-on-a-chip technology for the detection or quantification of multiple targets in a high-throughput approach. In particular, this is interesting for applications outside of analytical laboratories, such as point-of-care (POC) or on-site water screening where cost, measurement time, and the size of individual sensor devices are important factors to be considered...
September 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27602307/guiding-empiric-treatment-for-serious-bacterial-infections-via-point-of-care-formula-see-text-lactamase-characterization
#20
Akilan Palanisami, Shazia Khan, Sultan Sibel Erdem, Tayyaba Hasan
Fever is one of the most common symptoms of illness in infants and represents a clinical challenge due to the potential for serious bacterial infection. As delayed treatment for these infections has been correlated with increased morbidity and mortality, broad-spectrum [Formula: see text]-lactam antibiotics are often prescribed while waiting for microbiological lab results (1-3 days). However, the spread of antibiotic resistance via the [Formula: see text]-lactamase enzyme, which can destroy [Formula: see text]-lactam antibiotics, has confounded this paradigm; empiric antibiotic regimens are increasingly unable to cover all potential bacterial pathogens, leaving some infants effectively untreated until the pathogen is characterized...
2016: IEEE Journal of Translational Engineering in Health and Medicine
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