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https://www.readbyqxmd.com/read/28214369/diagnostic-accuracy-of-history-physical-exam-laboratory-tests-and-point-of-care-ultrasound-for-pediatric-acute-appendicitis-in-the-emergency-department-a-systematic-review-and-meta-analysis
#1
Roshanak Benabbas, Mark Hanna, Jay Shah, Richard Sinert
BACKGROUND: Acute appendicitis (AA) is the most common surgical emergency in children. Accurate and timely diagnosis is crucial but challenging due to atypical presentations and the inherent difficulty of obtaining a reliable history and physical examination in younger children. OBJECTIVES: To determine the utility of history, physical exam, laboratory tests, Pediatric Appendicitis Score (PAS) and Emergency Department-Point-of-Care Ultrasound (ED-POCUS) in the diagnosis of AA in ED pediatric patients...
February 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28213975/lab-in-a-tube-real-time-molecular-point-of-care-diagnostics-for-influenza-a-and-b-using-the-cobas%C3%A2-liat%C3%A2-system
#2
Willem Jg Melchers, Judith Kuijpers, Joanna Sickler, Janette Rahamat-Langendoen
BACKGROUND: Rapid diagnosis of influenza A and B is important for direct treatment decisions in patient care and for the reduction of in-hospital transmissions. The new real-time PCR based molecular point-of-care (POC) assay, the cobas(®) Influenza A/B test on the cobas(®) Liat® System (cobas(®) Liat® Influenza A/B assay), generated a PCR result in less than 20 minutes, was evaluated for the detection of influenza A and B. METHOD OF THE STUDY: 121 retrospectively collected respiratory specimens, previously analyzed with a routine influenza A/B test (Diagenode) were tested using the cobas(®) Liat® Influenza A/B assay...
February 18, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28211993/recent-lab-on-chip-developments-for-novel-drug-discovery
#3
REVIEW
Nauman Khalid, Isao Kobayashi, Mitsutoshi Nakajima
Microelectromechanical systems (MEMS) and micro total analysis systems (μTAS) revolutionized the biochemical and electronic industries, and this miniaturization process became a key driver for many markets. Now, it is a driving force for innovations in life sciences, diagnostics, analytical sciences, and chemistry, which are called 'lab-on-a-chip, (LOC)' devices. The use of these devices allows the development of fast, portable, and easy-to-use systems with a high level of functional integration for applications such as point-of-care diagnostics, forensics, the analysis of biomolecules, environmental or food analysis, and drug development...
February 17, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28167769/multifunctional-inexpensive-and-reusable-nanoparticle-printed-biochip-for-cell-manipulation-and-diagnosis
#4
Rahim Esfandyarpour, Matthew J DiDonato, Yuxin Yang, Naside Gozde Durmus, James S Harris, Ronald W Davis
Isolation and characterization of rare cells and molecules from a heterogeneous population is of critical importance in diagnosis of common lethal diseases such as malaria, tuberculosis, HIV, and cancer. For the developing world, point-of-care (POC) diagnostics design must account for limited funds, modest public health infrastructure, and low power availability. To address these challenges, here we integrate microfluidics, electronics, and inkjet printing to build an ultra-low-cost, rapid, and miniaturized lab-on-a-chip (LOC) platform...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28153714/validation-of-two-point-of-care-tests-against-standard-lab-measures-of-no-in-saliva-and-in-serum
#5
Ashwin Modi, Evangelia Morou-Bermudez, Jose Vergara, Rakesh Patel, Alexandria Nichols, Kaumudi Joshipura
No abstract text is available yet for this article.
January 30, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28152853/oncologists-opinions-and-experiences-with-electronic-release-of-radiology-and-pathology-results-to-patients
#6
Farnoosh Sheikhi, Eben Lloyd Rosenthal, Christopher Sharp, Mark K Buyyounouski, Steve Asch
: 162 Background: There is an emerging standard to provide patients rapid electronic access to elements of their medical records,; this practice is controversial among practicing oncologists. Previous studies have primarily reported on patient access to physician notes and lab tests in primary care. In oncology, the emotional import and complexity of the results may be greater, particularly for staging imaging and biopsies. We report the opinions and experiences of oncologists after enabling patient access to radiology and pathology results for four months during which time finalized results were released upon physician action or after seven days...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28148254/building-trust-and-rapport-early-in-the-new-doctor-patient-relationship-a-longitudinal-qualitative-study
#7
Bich N Dang, Robert A Westbrook, Sarah M Njue, Thomas P Giordano
BACKGROUND: New patients are a particularly vulnerable population because they are at high risk of missing a subsequent visit or dropping out of care completely. However, few data exist on what new patients value in the beginning of a relationship with a new provider. Persons with HIV infection may be an ideal population to study the drivers of a positive initial patient-provider relationship, as it is a chronic and serious condition that requires a reliable, ongoing relationship with a provider...
February 2, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28102419/towards-encoded-particles-for-highly-multiplexed-colorimetric-point-of-care-autoantibody-detection
#8
Gustav Svedberg, Yunjin Jeong, Hunjong Na, Jisung Jang, Peter Nilsson, Sunghoon Kwon, Jesper Gantelius, Helene Andersson Svahn
Highly multiplexed point of care tests could improve diagnostic accuracy and differential diagnostic capacity in for instance emergency medicine and low resource environments. Available technology platforms for POC biomarker detection are typically simplex or low-plexed, whereas common lab-based microarray systems allow for the simultaneous detection of thousands of DNA or protein biomarkers. In this study, we demonstrate a novel suspension particle array platform that utilizes 900 μm bricks for POC amenable colorimetric biomarker detection with an encoding capacity of over two million...
January 19, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28073898/two-stage-isothermal-enzymatic-amplification-for-concurrent-multiplex-molecular-detection
#9
Jinzhao Song, Changchun Liu, Michael G Mauk, Shelley C Rankin, James B Lok, Robert M Greenberg, Haim H Bau
BACKGROUND: The wide array of pathogens responsible for infectious diseases makes it difficult to identify causative pathogens with single-plex tests. Although multiplex PCR detects multiple targets, it is restricted to centralized laboratories, which delays test results or makes multiplexing unavailable, depriving healthcare providers of critical, real-time information. METHODS: To address the need for point-of-care (POC) highly multiplexed tests, we propose the 2-stage, nested-like, rapid (<40 min) isothermal amplification assay, dubbed rapid amplification (RAMP)...
January 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28050904/paper-based-analytical-biosensor-chip-designed-from-graphene-nanoplatelet-amphiphilic-diblock-co-polymer-composite-for-cortisol-detection-in-human-saliva
#10
Muhammad S Khan, Santosh K Misra, Zhen Wang, Enrique Daza, Aaron S Schwartz-Duval, Joseph M Kus, Debanjan Pan, Dipanjan Pan
Cortisol has been identified as a biomarker in saliva to monitor psychological stress. In this work, we report a label-free paper-based electrical biosensor chip to quantify salivary cortisol at a point-of-care (POC) level. A high specificity of the sensor chip to detect cortisol with a detection limit of 3 pg/mL was achieved by conjugating anticortisol antibody (anti-CAB) on top of gold (Au) microelectrodes using 3,3'-dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) as a self-assembled monolayer (SAM) agent...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28048668/tu-ab-202-01-multi-institutional-validation-study-of-commercially-available-deformable-image-registration-software-for-thoracic-images
#11
N Kadoya, Y Nakajima, M Saito, Y Miyabe, M Kurooka, S Kito, M Sasaki, Y Fujita, K Arai, K Tani, M Yagi, A Wakita, N Tohyama, K Jingu
PURPOSE: The purpose of this study was to assess the accuracy of commercially available deformable image registration (DIR) software for thoracic images on multi-institution. Furthermore, we determined the variation in the DIR accuracy among institutions due to different DIR algorithms and DIR procedures. METHODS: Thoracic four-dimensional (4D) CT images of ten patients with esophagus or lung cancer were used. Datasets for these patients were provided by DIR-lab (dir-lab...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28007038/semi-quantitative-method-for-staphylococci-magnetic-detection-in-raw-milk
#12
Carla Margarida Duarte, Carla Carneiro, Susana Cardoso, Paulo Peixeiro Freitas, Ricardo Bexiga
Bovine mastitis is the most costly disease for dairy farmers, hence, control measures to prevent it are crucial for dairy farm sustainability. Staphylococcus aureus is considered a major mastitis pathogen because of its impact on milk quality and low cure rates. Prevention of S. aureus mastitis includes segregation of infected animals, whilst treatment of such animals should be performed for a longer time to improve cure rates. This makes identification of S. aureus infected quarters and animals of significant importance...
December 23, 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27987361/analytical-evaluation-of-point-of-care-procalcitonin-pct-and-clinical-performances-in-an-unselected-population-as-compared-with-central-lab-pct-assay
#13
Anne Marie Dupuy, Quentin Chevrier, Yan Olejnik, Anne Sophie Bargnoux, Stéphanie Badiou, Jean Paul Cristol
No abstract text is available yet for this article.
December 17, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27958721/fast-size-selective-clog-free-isolation-of-rare-cancer-cells-from-whole-blood-at-a-liquid-liquid-interface
#14
Tae-Hyeong Kim, Minji Lim, Juhee Park, Jung Min Oh, Hyeongeun Kim, Hyunjin Jeong, Sun Ju Lee, Hee Chul Park, Sungmok Jung, Byung Chul Kim, Kyusang Lee, Mi-Hyun Kim, Do Youn Park, Gwang Ha Kim, Yoon-Kyoung Cho
Circulating tumor cells (CTCs) have great potential to provide minimally invasive ways for the early detection of cancer metastasis and for the response monitoring of various cancer treatments. Despite the clinical importance and progress of CTC-based cancer diagnostics, most of the current methods of enriching CTCs are difficult to implement in general hospital settings due to complex and time-consuming protocols. Among existing technologies, size-based isolation methods provide antibody-independent, relatively simple, and high throughput protocols...
December 13, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27897004/identifying-genetic-associations-with-variability-in-metabolic-health-and-blood-count-laboratory-values-diving-into-the-quantitative-traits-by-leveraging-longitudinal-data-from-an-ehr
#15
Shefali S Verma, Anastasia M Lucas, Daniel R Lavage, Joseph B Leader, Raghu Metpally, Sarathbabu Krishnamurthy, Frederick Dewey, Ingrid Borecki, Alexander Lopez, John Overton, John Penn, Jeffrey Reid, Sarah A Pendergrass, Gerda Breitwieser, Marylyn D Ritchie
A wide range of patient health data is recorded in Electronic Health Records (EHR). This data includes diagnosis, surgical procedures, clinical laboratory measurements, and medication information. Together this information reflects the patient's medical history. Many studies have efficiently used this data from the EHR to find associations that are clinically relevant, either by utilizing International Classification of Diseases, version 9 (ICD-9) codes or laboratory measurements, or by designing phenotype algorithms to extract case and control status with accuracy from the EHR...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896755/the-application-of-multiplex-biomarker-techniques-for-improved-stratification-and-treatment-of-schizophrenia-patients
#16
Johann Steiner, Paul C Guest, Hassan Rahmoune, Daniel Martins-de-Souza
In the case of major psychiatric disorders such as schizophrenia, shortcomings in the conversion of scientific discoveries into newer and safer treatment options has led to a loss of confidence and precipitated a crisis for large pharmaceutical companies. This chapter describes how incorporation of multiplex biomarker approaches into the clinical pipeline can lead to better patient characterization, delivery of novel treatment approaches and help to renew efforts in this important area. The development of specific biomarker test panels for disease prediction should facilitate early intervention strategies, which may help to slow disease development or progression...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27810632/satisfaction-and-self-confidence-with-nursing-clinical-simulation-novice-learners-medium-fidelity-and-community-settings
#17
Jaclynn Lubbers, Carol Rossman
BACKGROUND: Simulation is fast becoming a normative pedagogy for a portion of clinical time in undergraduate nursing programs in the U.S. Studies have shown positive outcomes in increasing self-confidence and satisfaction with simulation. The questions remain as to which fidelity of simulation best matches which learners, how early can simulation begin with novice students, and in which contexts can simulation be best used for these early learners. This study was undertaken to find out if novice students were able to demonstrate increased satisfaction and self-confidence with medium fidelity simulation in community based roles, as these students have no knowledge of acute care skills at this point in their learning...
January 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27775960/quality-of-sleep-and-coexistent-psychopathology-have-significant-impact-on-fatigue-burden-in-patients-with-inflammatory-bowel-disease
#18
Jana G Hashash, Claudia Ramos-Rivers, Ada Youk, Wai Kan Chiu, Kyle Duff, Miguel Regueiro, David G Binion, Ioannis Koutroubakis, Ashley Vachon, David Benhayon, Michael A Dunn, Eva M Szigethy
BACKGROUND: Fatigue is common in inflammatory bowel disease (IBD) patients and is associated with factors such as psychopathology, sleep quality, and disease activity. GOAL: To investigate the combined role of all the above factors in the burden of fatigue among IBD patients. STUDY: We conducted an observational study of adult patients enrolled in an IBD clinical research registry at a tertiary care clinic. Fatigue burden was defined by Item 1 of the Short-form IBD Questionnaire (SIBDQ), which is scored on a 7-point Likert scale...
October 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27756517/lab-on-a-chip-technologies-for-genodermatoses-recent-progress-and-future-perspectives
#19
REVIEW
Cui Hongzhou, Guo Shuping, Wang Wenju, Li Li, Wei Lulu, Deng Linjun, Li Jingmin, Ren Xiaoli, Bai Li
In recent years, molecular biology has proven to be a great asset in our understanding of mechanisms in genodermatoses. However, bench to bedside translation research lags far behind. Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Sample preparation, microfluidic reactions, and continuous monitoring systems can be integrated on a small chip. These advantages have attracted attention in various fields of clinical application including diagnosis of inherited skin diseases...
February 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27748042/in-situ-simulation-in-emergency-medicine-moving-beyond-the-simulation-lab
#20
Andrew Petrosoniak, Marc Auerbach, Ambrose H Wong, Christopher M Hicks
In situ simulation (ISS), a point of care training strategy that occurs within the patient care environment involving actual healthcare team members, provides additional benefits to centre-based simulation. ISS can serve several roles within emergency medicine (EM): improves provider/team performance, identifies and mitigates threats to patient safety and improves systems and infrastructure. The effective use of ISS fosters inter-professional team training and a culture of safety essential for high performance EM teams and resilient systems...
February 2017: Emergency Medicine Australasia: EMA
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