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https://www.readbyqxmd.com/read/27725740/microfluidics-based-point-of-care-test-for-serodiagnosis-of-lyme-disease
#1
Samiksha Nayak, Archana Sridhara, Rita Melo, Luciana Richer, Natalie H Chee, Jiyoon Kim, Vincent Linder, David Steinmiller, Samuel K Sia, Maria Gomes-Solecki
Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid lab-on-a-chip point of care (POC) assay for the serologic diagnosis of human Lyme disease. Following ELISA screening of 12 candidate antigens, we tested 8 on a microfluidic diagnostic system, called mChip-Ld, using a set of 60 serological samples...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27602780/nanoscale-electrochemical-sensor-arrays-redox-cycling-amplification-in-dual-electrode-systems
#2
Bernhard Wolfrum, Enno Kätelhön, Alexey Yakushenko, Kay J Krause, Nouran Adly, Martin Hüske, Philipp Rinklin
Micro- and nanofabriation technologies have a tremendous potential for the development of powerful sensor array platforms for electrochemical detection. The ability to integrate electrochemical sensor arrays with microfluidic devices nowadays provides possibilities for advanced lab-on-a-chip technology for the detection or quantification of multiple targets in a high-throughput approach. In particular, this is interesting for applications outside of analytical laboratories, such as point-of-care (POC) or on-site water screening where cost, measurement time, and the size of individual sensor devices are important factors to be considered...
September 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27536736/validation-of-the-genexpert%C3%A2-ct-ng-assay-for-use-with-male-pharyngeal-and-rectal-swabs
#3
R Geiger, D M Smith, S J Little, S R Mehta
OBJECTIVES: The GeneXpert(®) CT/NG (Cepheid, Sunnyvale, CA) assay is a point-of-care (POC) molecular diagnostic assay designed to rapidly test for the presence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC). However, the test is only approved for vaginal swabs, urine, and endocervical swabs. Here, we performed an evaluation of the GeneXpert(®) CT/NG assay to detect the presence of CT and GC on male pharyngeal and rectal swabs. METHODS: Men who have sex with men participating in an HIV and Sexually Transmitted Infection (STI) screening program providing consent were enrolled into the study...
2016: Austin Journal of HIV/AIDS Research
https://www.readbyqxmd.com/read/27508527/validation-of-the-accutrend-plus-point-of-care-triglyceride-analyzer-in-horses-ponies-and-donkeys
#4
Michaela C Pongratz, Hannah K Junge, Barbara Riond, Colin C Schwarzwald
OBJECTIVE: To assess the accuracy and reliability of a point-of-care (POC) triglyceride analyzer and to establish reference intervals for blood ([TRIG]POC/WB ) and plasma triglyceride concentrations ([TRIG]POC/PL ) in horses, ponies, and donkeys. DESIGN: Prospective study. SETTING: University teaching hospital. ANIMALS: 120 adult healthy equids (78 horses and ponies, 42 donkeys) and 79 equids suffering from hypertriglyceridemia (73 horses and ponies, 6 donkeys)...
September 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27429695/comparison-of-result-times-between-urine-and-whole-blood-point-of-care-pregnancy-testing
#5
Michael Gottlieb, Kristopher Wnek, Jordan Moskoff, Errick Christian, John Bailitz
INTRODUCTION: Point-of-care (POC) pregnancy testing is commonly performed in the emergency department (ED). One prior study demonstrated equivalent accuracy between urine and whole blood for one common brand of POC pregnancy testing. Our study sought to determine the difference in result times when comparing whole blood versus urine for the same brand of POC pregnancy testing. METHODS: We conducted a prospective, observational study at an urban, academic, tertiary care hospital comparing the turnaround time between order and result for urine and whole blood pregnancy tests collected according to standard protocol without intervention from the investigators...
July 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27406947/thirty-five-years-of-cd4-t-cell-counting-in-hiv-infection-from-flow-cytometry-in-the-lab-to-point-of-care-testing-in-the-field
#6
L Kestens, F Mandy
CD4 T-cell counting was introduced in clinical laboratories shortly after the discovery of the human immune deficiency virus (HIV) in the early eighties. In western clinical laboratories, improvements in the CD4 T-cell counting methods were mainly driven by progress in the field of flow cytometry and immunology. In contrast, the development of dedicated CD4 T-cell counting technologies were needs driven. When antiretroviral treatment was made available on a large scale by international Acquired Immune Deficiency Syndrome (AIDS) relief programs to HIV+ patients living in low income countries in 2003, there was a distinct need for simplified and affordable CD4 T-cell counting technologies...
July 12, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27380817/programmable-bio-nanochip-platform-a-point-of-care-biosensor-system-with-the-capacity-to-learn
#7
Michael P McRae, Glennon Simmons, Jorge Wong, John T McDevitt
The combination of point-of-care (POC) medical microdevices and machine learning has the potential transform the practice of medicine. In this area, scalable lab-on-a-chip (LOC) devices have many advantages over standard laboratory methods, including faster analysis, reduced cost, lower power consumption, and higher levels of integration and automation. Despite significant advances in LOC technologies over the years, several remaining obstacles are preventing clinical implementation and market penetration of these novel medical microdevices...
July 19, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27314345/spr-and-spr-imaging-recent-trends-in-developing-nanodevices-for-detection-and-real-time-monitoring-of-biomolecular-events
#8
REVIEW
Mihaela Puiu, Camelia Bala
In this paper we review the underlying principles of the surface plasmon resonance (SPR) technique, particularly emphasizing its advantages along with its limitations regarding the ability to discriminate between the specific binding response and the interfering effects from biological samples. While SPR sensors were developed almost three decades, SPR detection is not yet able to reduce the time-consuming steps of the analysis, and is hardly amenable for miniaturized, portable platforms required in point-of-care (POC) testing...
2016: Sensors
https://www.readbyqxmd.com/read/27304061/use-of-rapid-point-of-care-assays-by-private-practitioners-in-chennai-india-priorities-for-tuberculosis-diagnostic-testing
#9
Liza Bronner Murrison, Ramya Ananthakrishnan, Sumanya Sukumar, Sheela Augustine, Nalini Krishnan, Madhukar Pai, David W Dowdy
SETTING: Private practitioners are frequently the first point of healthcare contact for patients with tuberculosis (TB) in India. As new molecular tests are developed for point-of-care (POC) diagnosis of TB, it is imperative to understand these individuals' practices and preferences for POC testing. OBJECTIVE: To evaluate rapid testing practices and identify priorities for novel POC TB tests among private practitioners in Chennai. DESIGN: We conducted a cross-sectional survey of 228 practitioners practicing in the private sector from January 2014 to February 2015 who saw at least one TB patient in the previous year...
2016: PloS One
https://www.readbyqxmd.com/read/27179566/microfluidic-integrated-dna-nanobiosensors
#10
REVIEW
M I Haque Ansari, Shabir Hassan, Ahsanulhaq Qurashi, Firdous Ahmad Khanday
Over the last few decades, an increased demand has emerged for integrating biosensors with microfluidic- and nanofluidic-based lab-on-chip (LOC) devices for point-of-care (POC) diagnostics, in the medical industry and environmental monitoring of pathogenic threat agents. Such a merger of microfluidics with biosensing technologies allows for the precise control of volumes, as low as one nanolitre and the integration of various types of bioassays on a single miniaturized platform. This integration offers several favorable advantages, such as low reagent consumption, automation of sample preparation, reduction in processing time, low cost analysis, minimal handling of hazardous materials, high detection accuracy, portability and disposability...
November 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27103879/correction-of-point-of-care-inr-results-in-warfarin-patients
#11
Christopher Richter, James Taylor, Jonathan Shuster
BACKGROUND: The measurement of international normalization ratio (INR) may be done by venous blood draw and use of a standard lab, or by fingerstick, using a point of care (POC) device such as the CoaguChek XS(®) (Roche Diagnostics), and the CoaguChek XS(®) has been validated to meet the International Organization for Standardization (ISO) performance requirements. OVERVIEW: The goal of this study was to determine a correction factor for Coaguchek XS INR levels to a predicted venipuncture (VP) INR level...
March 2016: Point of Care
https://www.readbyqxmd.com/read/27083239/point-of-care-devices-for-physiological-measurements-in-field-conditions-a-smorgasbord-of-instruments-and-validation-procedures
#12
Caroline Lindholm, Jordi Altimiras
Point-of-care (POC) devices provide quick diagnostic results that increase the efficiency of patient care. Many POC devices are currently available to measure metabolites, blood gases, hormones, disease biomarkers or pathogens in samples as diverse as blood, urine, feces or exhaled breath. This diversity is potentially very useful for the comparative physiologist in field studies if proper validation studies are carried out to justify the accuracy of the devices in non-human species under different conditions...
April 12, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/26998819/outcome-at-30-days-for-low-risk-chest-pain-patients-assessed-using-an-accelerated-diagnostic-pathway-in-the-emergency-department
#13
Robert Meek, George Braitberg, Louise Cullen, Martin Than, Andis Graudins, Deirdre Glynn
OBJECTIVES: Primary: to determine incidence of 30 day major adverse cardiac events (MACE) in patients discharged from the ED following assessment using an accelerated diagnostic pathway (ADP). Secondary: to determine incidence of 30 day MACE for all ADP patients. METHODS: Monash Health ED patients thought at low risk for acute myocardial infarction (AMI) or hospital admission are assessed using an ADP, based on arrival and 90 min point-of-care (POC) cardiac troponin I and myoglobin concentration...
June 2016: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/26946282/transforming-the-blood-glucose-meter-into-a-general-healthcare-meter-for-in-vitro-diagnostics-in-mobile-health
#14
Tian Lan, Jingjing Zhang, Yi Lu
Recent advances in mobile network and smartphones have provided an enormous opportunity for transforming in vitro diagnostics (IVD) from central labs to home or other points of care (POC). A major challenge to achieving the goal is a long time and high costs associated with developing POC IVD devices in mobile Health (mHealth). Instead of developing a new POC device for every new IVD target, we and others are taking advantage of decades of research, development, engineering and continuous improvement of the blood glucose meter (BGM), including those already integrated with smartphones, and transforming the BGM into a general healthcare meter for POC IVDs of a wide range of biomarkers, therapeutic drugs and other analytical targets...
May 2016: Biotechnology Advances
https://www.readbyqxmd.com/read/26652014/point-of-care-testing-in-india-missed-opportunities-to-realize-the-true-potential-of-point-of-care-testing-programs
#15
Nora Engel, Gayatri Ganesh, Mamata Patil, Vijayashree Yellappa, Caroline Vadnais, Nitika Pant Pai, Madhukar Pai
BACKGROUND: The core objective of any point-of-care (POC) testing program is to ensure that testing will result in an actionable management decision (e.g. referral, confirmatory test, treatment), within the same clinical encounter (e.g. POC continuum). This can but does not have to involve rapid tests. Most studies on POC testing focus on one specific test and disease in a particular healthcare setting. This paper describes the actors, technologies and practices involved in diagnosing major diseases in five Indian settings - the home, community, clinics, peripheral laboratories and hospitals...
2015: BMC Health Services Research
https://www.readbyqxmd.com/read/26599482/integration-of-an-optical-cmos-sensor-with-a-microfluidic-channel-allows-a-sensitive-readout-for-biological-assays-in-point-of-care-tests
#16
Bieke Van Dorst, Monica Brivio, Elfried Van Der Sar, Marko Blom, Simon Reuvekamp, Simone Tanzi, Roelf Groenhuis, Adewole Adojutelegan, Erik-Jan Lous, Filip Frederix, Lieven J Stuyver
In this manuscript, a microfluidic detection module, which allows a sensitive readout of biological assays in point-of-care (POC) tests, is presented. The proposed detection module consists of a microfluidic flow cell with an integrated Complementary Metal-Oxide-Semiconductor (CMOS)-based single photon counting optical sensor. Due to the integrated sensor-based readout, the detection module could be implemented as the core technology in stand-alone POC tests, for use in mobile or rural settings. The performance of the detection module was demonstrated in three assays: a peptide, a protein and an antibody detection assay...
April 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/26593219/dose-dependent-response-of-personal-glucose-meters-to-nicotinamide-coenzymes-applications-to-point-of-care-diagnostics-of-many-non-glucose-targets-in-a-single-step
#17
Jingjing Zhang, Yu Xiang, Miao Wang, Ananda Basu, Yi Lu
We report a discovery that personal glucose meters (PGMs) can give a dose-dependent response to nicotinamide coenzymes, such as the reduced form of nicotinamide adenine dinucleotide (NADH). We have developed methods that take advantage of this discovery to perform one-step homogeneous assays of many non-glucose targets that are difficult to recognize by DNAzymes, aptamers, or antibodies, and without the need for conjugation and multiple steps of sample dilution, separation, or fluid manipulation. The methods are based on the target-induced consumption or production of NADH through cascade enzymatic reactions...
January 11, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/26578003/microfluidic-emulation-of-mechanical-circulatory-support-device-shear-mediated-platelet-activation
#18
Annalisa Dimasi, Marco Rasponi, Jawaad Sheriff, Wei-Che Chiu, Danny Bluestein, Phat L Tran, Marvin J Slepian, Alberto Redaelli
Thrombosis of ventricular assist devices (VADs) compromises their performance, with associated risks of systemic embolization, stroke, pump stop and possible death. Anti-thrombotic (AT) drugs, utilized to limit thrombosis, are largely dosed empirically, with limited testing of their efficacy. Further, such testing, if performed, typically examines efficacy under static conditions, which is not reflective of actual shear-mediated flow. Here we adopted our previously developed Device Thrombogenicity Emulation methodology to design microfluidic platforms able to emulate representative shear stress profiles of mechanical circulatory support (MCS) devices...
December 2015: Biomedical Microdevices
https://www.readbyqxmd.com/read/26562630/self-powered-switch-controlled-nucleic-acid-extraction-system
#19
Kyungsup Han, Yong-Jin Yoon, Yong Shin, Mi Kyoung Park
Over the past few decades, lab-on-a-chip (LOC) technologies have played a great role in revolutionizing the way in vitro medical diagnostics are conducted and transforming bulky and expensive laboratory instruments and labour-intensive tests into easy to use, cost-effective miniaturized systems with faster analysis time, which can be used for near-patient or point-of-care (POC) tests. Fluidic pumps and valves are among the key components for LOC systems; however, they often require on-line electrical power or batteries and make the whole system bulky and complex, therefore limiting its application to POC testing especially in low-resource setting...
January 7, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/26368287/a-point-of-care-immunosensor-for-human-chorionic-gonadotropin-in-clinical-urine-samples-using-a-cuneated-polysilicon-nanogap-lab-on-chip
#20
S R Balakrishnan, U Hashim, Subash C B Gopinath, P Poopalan, H R Ramayya, M Iqbal Omar, R Haarindraprasad, P Veeradasan
Human chorionic gonadotropin (hCG), a glycoprotein hormone secreted from the placenta, is a key molecule that indicates pregnancy. Here, we have designed a cost-effective, label-free, in situ point-of-care (POC) immunosensor to estimate hCG using a cuneated 25 nm polysilicon nanogap electrode. A tiny chip with the dimensions of 20.5 × 12.5 mm was fabricated using conventional lithography and size expansion techniques. Furthermore, the sensing surface was functionalized by (3-aminopropyl)triethoxysilane and quantitatively measured the variations in hCG levels from clinically obtained human urine samples...
2015: PloS One
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