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https://www.readbyqxmd.com/read/29189595/fast-and-sensitive-automated-point-of-care-urine-dips
#1
Laurie Malia, Kaitlin Strumph, Sharon Smith, John Brancato, Stephanie T Johnson, Henry Chicaiza
OBJECTIVE: Point-of-care (POC) urine dipstick is a highly used test in the pediatric emergency department (PED) owing to its fast turn-around time and inexpensive cost. Past studies have shown hand-held urine dipsticks and automated urinalysis in children younger than 48 months to be sensitive predictors for urinary tract infection (UTI). It is hypothesized that POC dip testing is as accurate as laboratory urinalysis in the diagnosis of UTI. METHODS: A retrospective chart review was conducted on patients (aged birth through 18 years) presenting to a PED between January 2015 and December 2015...
November 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29131592/a-paper-plastic-hybrid-microfluidic-device-for-smartphone-based-colorimetric-analysis-of-urine
#2
M Jalal Uddin, Gyeong Jun Jin, Joon Sub Shim
In this work, a disposable paper-plastic hybrid microfluidic lab-on-a-chip (LOC) has been developed and successfully applied for the colorimetric measurement of urine by the smartphone-based optical platform using an "UrineAnalysis" Android app. The developed device was cost-effectively implemented as a stand-alone hybrid LOC by incorporating the paper-based conventional reagent test strip inside the plastic-based LOC microchannel. The LOC device quantitatively investigated the small volume (40 µL) of urine analytes for the colorimetric reaction of glucose, protein, pH and red blood cell (RBC) in integration with the finger-actuating micro pump...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29129601/on-chip-signal-amplification-of-magnetic-bead-based-immunoassay-by-aviating-magnetic-bead-chains
#3
Uddin M Jalal, Gyeong Jun Jin, Kyu Shik Eom, Min Ho Kim, Joon S Shim
In this work, a Lab-on-a-Chip (LOC) platform is used to electromagnetically actuate magnetic bead chains for an enhanced immunoassay. Custom-made electromagnets generate a magnetic field to form, rotate, lift and lower the magnetic bead chains (MBCs). The cost-effective, disposable LOC platform was made with a polymer substrate and an on-chip electrochemical sensor patterned via the screen-printing process. The movement of the MBCs is controlled to improve the electrochemical signal up to 230% when detecting beta-type human chorionic gonadotropin (β-hCG)...
November 6, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29095669/the-anatomy-of-a-nonfaradaic-electrochemical-biosensor
#4
Hunter Stevenson, Nandhinee Radha Shanmugam, Anjan Paneer Selvam, Shalini Prasad
Point-of-care (POC) testing has revolutionized diagnostic healthcare, bringing medical results directly and immediately to the patient. With faster diagnostics, more immediate clinical management decisions can be made. POC tests most often use a dipstick or swab format to detect the presence of a pathogen, disease, or other relevant biomarker. In these formats, the POC tests eliminate the need for complex lab equipment and trained personnel to collect, process, and analyze sample data for simple diagnostics...
November 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29068663/portable-gmr-handheld-platform-for-the-detection-of-influenza-a-virus
#5
Kai Wu, Todd Klein, Venkatramana D Krishna, Diqing Su, Andres M Perez, Jian-Ping Wang
Influenza A virus (IAV) is a common respiratory pathogen infecting many hosts including humans, pigs (swine influenza virus or SIV), and birds (avian influenza virus or AIV). Monitoring swine and avian influenza viruses in the wild, farms, and live poultry markets is of great significance for human and veterinary public health. A portable, sensitive, and quantitative immunoassay device will be of high demand especially in the rural and resource-limited areas. We report herein our Z-Lab point-of-care (POC) device for sensitive and specific detection of swine influenza viruses with minimum sample handling and laboratory skill requirements...
October 25, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29060835/phonequant-a-smartphone-based-quantitative-immunoassay-analyser
#6
Malay Ilesh Shah, Jayaraj Joseph, Ujwal Sriharsha Sanne, Mohanasankar Sivaprakasam
There is a vital need for portable and cost-effective point-of-care (PoC) testing technologies that provide reliable and rapid results. Lateral Flow Immunoassays (LFIA) are suitable PoC diagnostic tools with the potential for use in a wide variety of field applications ranging from uses in clinical diagnostics to aiding law enforcement. Quick and reliable diagnosis of non-communicable diseases (NCD) like diabetes is vital especially in developing countries like India where the burden of these diseases is very high and is increasing day by day...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28918967/accuracy-of-bedside-point-of-care-testing-in-critical-emergency-department-patients
#7
Braden W McIntosh, Jerina Vasek, Maria Taylor, Deborah Le Blanc, Henry C Thode, Adam J Singer
BACKGROUND: Point-of-care (POC) testing reduces laboratory turn-around having the potential to improve timely diagnosis and management. We compared the accuracy of nurse performed POC and core laboratory testing and determined whether deviations between the two were clinically meaningful. METHODS: We performed a prospective, observational study on a convenience sample of 50 critical care ED patients in whom a POC chemistry and hematocrit was ordered. Blood samples were divided into 2 aliquots; one sample was tested by the treating nurse using a handheld POC device and the other sample was tested in the core laboratory...
September 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28906279/the-value-of-point-of-care-cd4-and-laboratory-viral-load-in-tailoring-antiretroviral-therapy-monitoring-strategies-to-resource-limitations
#8
Emily P Hyle, Ilesh V Jani, Katherine L Rosettie, Robin Wood, Benjamin Osher, Stephen Resch, Pamela P Pei, Paolo Maggiore, Kenneth A Freedberg, Trevor Peter, Robert A Parker, Rochelle P Walensky
OBJECTIVE: To examine the clinical and economic value of point-of-care CD4 (POC-CD4) or viral load monitoring compared with current practices in Mozambique, a country representative of the diverse resource limitations encountered by HIV treatment programs in sub-Saharan Africa. DESIGN/METHODS: We use the Cost-Effectiveness of Preventing AIDS Complications-International model to examine the clinical impact, cost (2014 US$), and incremental cost-effectiveness ratio [$/year of life saved (YLS)] of ART monitoring strategies in Mozambique...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28877177/an-in-vitro-diagnostic-certified-point-of-care-single-nucleotide-test-for-il28b-polymorphisms
#9
Darragh Duffy, Estelle Mottez, Shaun Ainsworth, Tan-Phuc Buivan, Aurelie Baudin, Muriel Vray, Ben Reed, Arnaud Fontanet, Alexandra Rohel, Ventzislava Petrov-Sanchez, Laurent Abel, Ioannis Theodorou, Gino Miele, Stanislas Pol, Matthew L Albert
Numerous genetic polymorphisms have been identified as associated with disease or treatment outcome, but the routine implementation of genotyping into actionable medical care remains limited. Point-of-care (PoC) technologies enable rapid and real-time treatment decisions, with great potential for extending molecular diagnostic approaches to settings with limited medical infrastructure (e.g., CLIA certified diagnostic laboratories). With respect to resource-limited settings, there is a need for simple devices to implement biomarker guided treatment strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28810994/comparison-of-point-of-care-versus-laboratory-troponin-testing-in-an-emergency-department-setting
#10
Michael Juliano, Courtney Wason
BACKGROUND: There have been concerns regarding troponin results accuracy between point-of-care (POC) testing preformed in an emergency department (ED) setting and laboratory testing. The purpose of this study was to compare the results of cardiac troponin I testing as concerns POC testing and laboratory analysis as a way to show that these results are interchangeable. METHODS: A retrospective chart review was performed from October 2012 through September 2013 to identify all patients who presented to the ED that received both a POC and laboratory troponin associated with the same blood draw...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28692541/the-value-of-point-of-care-cd4-and-laboratory-viral-load-in-tailoring-art-monitoring-strategies-to-resource-limitations
#11
Emily P Hyle, Ilesh V Jani, Katherine L Rosettie, Robin Wood, Benjamin Osher, Stephen Resch, Pamela P Pei, Paolo Maggiore, Kenneth A Freedberg, Trevor Peter, Robert A Parker, Rochelle P Walensky
OBJECTIVE: To examine the clinical and economic value of point-of-care CD4 (POC-CD4) or viral load (VL) monitoring compared to current practices in Mozambique, a country representative of the diverse resource limitations encountered by HIV treatment programs in sub-Saharan Africa. DESIGN/METHODS: We use the CEPAC-I model to examine the clinical impact, cost (2014 US$), and incremental cost-effectiveness ratio (ICER, $/year of life saved [YLS]) of ART monitoring strategies in Mozambique...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28637514/performance-of-point-of-care-international-normalized-ratio-measurement-to-diagnose-trauma-induced-coagulopathy
#12
Thomas Mistral, Yvonnick Boué, Jean-Luc Bosson, Pauline Manhes, Jules Greze, Julien Brun, Pierre Albaladejo, Jean-François Payen, Pierre Bouzat
BACKGROUND: Trauma-induced coagulopathy (TIC) is a common feature after severe trauma. Detection of TIC is based upon classic coagulation tests including international normalized ratio (INR) value. Point-of-care (POC) devices have been developed to rapidly measure INR at the bedside on whole blood. The aim of the study was to test the precision of the Coagucheck® XS Pro device for INR measurement at hospital admission after severe trauma. METHODS: We conducted a prospective observational study in a French level I trauma center...
June 21, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28573279/an-automated-and-portable-microfluidic-chemiluminescence-immunoassay-for-quantitative-detection-of-biomarkers
#13
Binfeng Hu, Juanjuan Li, Lei Mou, Yong Liu, Jinqi Deng, Wei Qian, Jiashu Sun, Ruitao Cha, Xingyu Jiang
Microfluidic platforms capable of automated, rapid, sensitive, and quantitative detection of biomarkers from patient samples could make a major impact on clinical or point-of-care (POC) diagnosis. In this work, we realize an automated diagnostic platform composed of two main components: (1) a disposable, self-contained, and integrated microfluidic chip and (2) a portable instrument that carries out completely automated operations. To demonstrate its potential for real-world application, we use injection molding for mass fabrication of the main components of disposable microfluidic chips...
June 27, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28496152/rapid-self-driven-liquid-mixing-on-open-surface-microfluidic-platforms
#14
Jared M Morrissette, Pallab Sinha Mahapatra, Aritra Ghosh, Ranjan Ganguly, Constantine M Megaridis
Self-driven surface micromixers (SDSM) relying on patterned-wettability technology provide an elegant solution for low-cost, point-of-care (POC) devices and lab-on-a-chip (LOC) applications. We present a SDSM fabricated by strategically patterning three wettable wedge-shaped tracks onto a non-wettable, flat surface. This SDSM operates by harnessing the wettability contrast and the geometry of the patterns to promote mixing of small liquid volumes (µL droplets) through a combination of coalescence and Laplace pressure-driven flow...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28452329/label-free-sno-sub-2-sub-nanowire-fet-biosensor-for-protein-detection
#15
Markus Hubertus Jakob, Bo Dong, Sebastian Gutsch, Claire Chatelle, Abinaya Krishnaraja, Wilfried Weber, Margit Zacharias
Novel tin oxide field-effect-transistors (SnO<sub>2</sub> NW-FET) for pH and protein detection applicable in the healthcare sector are reported. With the presented SnO<sub>2</sub> NW-FET the proof-of-concept of a bio-sensing device is demonstrated using the carrier transport control of the FET channel by a (bio-) liquid modulated gate. Ultra-thin Al<sub>2</sub>O<sub>3</sub> fabricated by a low temperature atomic layer deposition (ALD) process represents a sensitive layer to H<sup>+</sup> ions safeguarding the nanowire at the same time...
April 28, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28435491/agreement-between-serum-assays-performed-in-ed-point-of-care-and-hospital-central-laboratories
#16
Meir Dashevsky, Steven L Bernstein, Carol L Barsky, Richard A Taylor
INTRODUCTION: Point-of-care (POC) testing allows for more time-sensitive diagnosis and treatment in the emergency department (ED) than sending blood samples to the hospital central laboratory (CL). However, many ED patients have blood sent to both, either out of clinical custom, or because clinicians do not trust the POC values. The objective of this study was to examine the level of agreement between POC and CL values in a large cohort of ED patients. METHODS: In an urban, Level I ED that sees approximately 120,000 patients/year, all patients seen between March 1, 2013, and October 1, 2014, who had blood sent to POC and CL labs had levels of agreement measured between serum sodium, potassium, blood urea nitrogen (BUN), creatinine, and hematocrit...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28420603/the-coags-uncomplicated-app-fulfilling-educational-gaps-around-diagnosis-and-laboratory-testing-of-coagulation-disorders
#17
Craig Kessler, Ellinor I Peerschke, Meera B Chitlur, Roshni Kulkarni, Natalia Holot, David L Cooper
BACKGROUND: Patients with coagulation disorders may present to a variety of physician specialties; however, accurate and efficient diagnosis can be challenging for physicians not specialized in hematology, due to identified gaps in knowledge around appropriate laboratory assays and interpretation of test results. Coags Uncomplicated was developed to fill this unmet educational need by increasing practical knowledge of coagulation disorders among nonexpert physicians and other health care professionals (HCPs) in a point-of-care (POC) setting...
April 18, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28397461/analytical-and-clinical-validation-of-a-point-of-care-cardiac-troponin-t-test-with-an-improved-detection-limit
#18
Carsten Jungbauer, Julian Hupf, Evangelos Giannitsis, Johann Frick, Anna Slagman, Christoph Ehret, Nicolas Herbert, Christine Jung, Rainer Zerback, Thomas Bertsch, Michael Christ
BACKGROUND: The point-of-care test Roche CARDIAC POC Troponin T (PoC TnT) is an improved assay which has been developed for the Roche cobas h 232 system. METHODS: We performed a multicentre evaluation (four sites) to assess the analytical performance of the PoC TnT assay and to compare it with the central laboratory Elecsys® troponin T high sensitive (lab cTnT-hs) assay. RESULTS: The relative mean differences found in method comparisons of PoC TnT vs...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28386077/an-assay-system-for-point-of-care-diagnosis-of-tuberculosis-using-commercially-manufactured-pcb-technology
#19
Daniel Evans, Konstantinos I Papadimitriou, Louise Greathead, Nikolaos Vasilakis, Panagiotis Pantelidis, Peter Kelleher, Hywel Morgan, Themistoklis Prodromakis
Rapid advances in clinical technologies, detection sensitivity and analytical throughput have delivered a significant expansion in our knowledge of prognostic and diagnostic biomarkers in many common infectious diseases, such as Tuberculosis (TB). During the last decade, a significant number of approaches to TB diagnosis have been attempted at Point-of-Care (PoC), exploiting a large variation of techniques and materials. In this work, we describe an electronics-based Enzyme-Linked ImmunoSorbent Assay (eELISA), using a Lab-on-a-Printed Circuit Board (LoPCB) approach, for TB diagnosis based on cytokine detection...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28362329/bench-top-fabrication-of-an-all-pdms-microfluidic-electrochemical-cell-sensor-integrating-micro-nanostructured-electrodes
#20
Sokunthearath Saem, Yujie Zhu, Helen Luu, Jose Moran-Mirabal
In recent years, efforts in the development of lab-on-a-chip (LoC) devices for point-of-care (PoC) applications have increased to bring affordable, portable, and sensitive diagnostics to the patients' bedside. To reach this goal, research has shifted from using traditional microfabrication methods to more versatile, rapid, and low-cost options. This work focuses on the benchtop fabrication of a highly sensitive, fully transparent, and flexible poly (dimethylsiloxane) (PDMS) microfluidic (μF) electrochemical cell sensor...
March 31, 2017: Sensors
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