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https://www.readbyqxmd.com/read/28420603/the-coags-uncomplicated-app-fulfilling-educational-gaps-around-diagnosis-and-laboratory-testing-of-coagulation-disorders
#1
Craig Kessler, Ellinor I Peerschke, Meera B Chitlur, Roshni Kulkarni, Natalia Holot, David L Cooper
BACKGROUND: Patients with coagulation disorders may present to a variety of physician specialties; however, accurate and efficient diagnosis can be challenging for physicians not specialized in hematology, due to identified gaps in knowledge around appropriate laboratory assays and interpretation of test results. Coags Uncomplicated was developed to fill this unmet educational need by increasing practical knowledge of coagulation disorders among nonexpert physicians and other health care professionals (HCPs) in a point-of-care (POC) setting...
April 18, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28397461/analytical-and-clinical-validation-of-a-point-of-care-cardiac-troponin-t-test-with-an-improved-detection-limit
#2
Carsten Jungbauer, Julian Hupf, Evangelos Giannitsis, Johann Frick, Anna Slagman, Christoph Ehret, Nicolas Herbert, Christine Jung, Rainer Zerback, Thomas Bertsch, Michael Christ
BACKGROUND: The point-of-care test Roche CARDIAC POC Troponin T (PoC TnT) is an improved assay which has been developed for the Roche cobas h 232 system. METHODS: We performed a multicentre evaluation (four sites) to assess the analytical performance of the PoC TnT assay and to compare it with the central laboratory Elecsys® troponin T high sensitive (lab cTnT-hs) assay. RESULTS: The relative mean differences found in method comparisons of PoC TnT vs...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28386077/an-assay-system-for-point-of-care-diagnosis-of-tuberculosis-using-commercially-manufactured-pcb-technology
#3
Daniel Evans, Konstantinos I Papadimitriou, Louise Greathead, Nikolaos Vasilakis, Panagiotis Pantelidis, Peter Kelleher, Hywel Morgan, Themistoklis Prodromakis
Rapid advances in clinical technologies, detection sensitivity and analytical throughput have delivered a significant expansion in our knowledge of prognostic and diagnostic biomarkers in many common infectious diseases, such as Tuberculosis (TB). During the last decade, a significant number of approaches to TB diagnosis have been attempted at Point-of-Care (PoC), exploiting a large variation of techniques and materials. In this work, we describe an electronics-based Enzyme-Linked ImmunoSorbent Assay (eELISA), using a Lab-on-a-Printed Circuit Board (LoPCB) approach, for TB diagnosis based on cytokine detection...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28362329/bench-top-fabrication-of-an-all-pdms-microfluidic-electrochemical-cell-sensor-integrating-micro-nanostructured-electrodes
#4
Sokunthearath Saem, Yujie Zhu, Helen Luu, Jose Moran-Mirabal
In recent years, efforts in the development of lab-on-a-chip (LoC) devices for point-of-care (PoC) applications have increased to bring affordable, portable, and sensitive diagnostics to the patients' bedside. To reach this goal, research has shifted from using traditional microfabrication methods to more versatile, rapid, and low-cost options. This work focuses on the benchtop fabrication of a highly sensitive, fully transparent, and flexible poly (dimethylsiloxane) (PDMS) microfluidic (μF) electrochemical cell sensor...
March 31, 2017: Sensors
https://www.readbyqxmd.com/read/28213975/lab-in-a-tube-real-time-molecular-point-of-care-diagnostics-for-influenza-a-and-b-using-the-cobas%C3%A2-liat%C3%A2-system
#5
Willem Jg Melchers, Judith Kuijpers, Joanna Sickler, Janette Rahamat-Langendoen
BACKGROUND: Rapid diagnosis of influenza A and B is important for direct treatment decisions in patient care and for the reduction of in-hospital transmissions. The new real-time PCR based molecular point-of-care (POC) assay, the cobas(®) Influenza A/B test on the cobas(®) Liat® System (cobas(®) Liat® Influenza A/B assay), generated a PCR result in less than 20 minutes, was evaluated for the detection of influenza A and B. METHOD OF THE STUDY: 121 retrospectively collected respiratory specimens, previously analyzed with a routine influenza A/B test (Diagenode) were tested using the cobas(®) Liat® Influenza A/B assay...
February 18, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28167769/multifunctional-inexpensive-and-reusable-nanoparticle-printed-biochip-for-cell-manipulation-and-diagnosis
#6
Rahim Esfandyarpour, Matthew J DiDonato, Yuxin Yang, Naside Gozde Durmus, James S Harris, Ronald W Davis
Isolation and characterization of rare cells and molecules from a heterogeneous population is of critical importance in diagnosis of common lethal diseases such as malaria, tuberculosis, HIV, and cancer. For the developing world, point-of-care (POC) diagnostics design must account for limited funds, modest public health infrastructure, and low power availability. To address these challenges, here we integrate microfluidics, electronics, and inkjet printing to build an ultra-low-cost, rapid, and miniaturized lab-on-a-chip (LOC) platform...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28102419/towards-encoded-particles-for-highly-multiplexed-colorimetric-point-of-care-autoantibody-detection
#7
Gustav Svedberg, Yunjin Jeong, Hunjong Na, Jisung Jang, Peter Nilsson, Sunghoon Kwon, Jesper Gantelius, Helene Andersson Svahn
Highly multiplexed point of care tests could improve diagnostic accuracy and differential diagnostic capacity in for instance emergency medicine and low resource environments. Available technology platforms for POC biomarker detection are typically simplex or low-plexed, whereas common lab-based microarray systems allow for the simultaneous detection of thousands of DNA or protein biomarkers. In this study, we demonstrate a novel suspension particle array platform that utilizes 900 μm bricks for POC amenable colorimetric biomarker detection with an encoding capacity of over two million...
January 19, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28073898/two-stage-isothermal-enzymatic-amplification-for-concurrent-multiplex-molecular-detection
#8
Jinzhao Song, Changchun Liu, Michael G Mauk, Shelley C Rankin, James B Lok, Robert M Greenberg, Haim H Bau
BACKGROUND: The wide array of pathogens responsible for infectious diseases makes it difficult to identify causative pathogens with single-plex tests. Although multiplex PCR detects multiple targets, it is restricted to centralized laboratories, which delays test results or makes multiplexing unavailable, depriving healthcare providers of critical, real-time information. METHODS: To address the need for point-of-care (POC) highly multiplexed tests, we propose the 2-stage, nested-like, rapid (<40 min) isothermal amplification assay, dubbed rapid amplification (RAMP)...
March 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28050904/paper-based-analytical-biosensor-chip-designed-from-graphene-nanoplatelet-amphiphilic-diblock-co-polymer-composite-for-cortisol-detection-in-human-saliva
#9
Muhammad S Khan, Santosh K Misra, Zhen Wang, Enrique Daza, Aaron S Schwartz-Duval, Joseph M Kus, Debanjan Pan, Dipanjan Pan
Cortisol has been identified as a biomarker in saliva to monitor psychological stress. In this work, we report a label-free paper-based electrical biosensor chip to quantify salivary cortisol at a point-of-care (POC) level. A high specificity of the sensor chip to detect cortisol with a detection limit of 3 pg/mL was achieved by conjugating anticortisol antibody (anti-CAB) on top of gold (Au) microelectrodes using 3,3'-dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) as a self-assembled monolayer (SAM) agent...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/27725740/microfluidics-based-point-of-care-test-for-serodiagnosis-of-lyme-disease
#10
Samiksha Nayak, Archana Sridhara, Rita Melo, Luciana Richer, Natalie H Chee, Jiyoon Kim, Vincent Linder, David Steinmiller, Samuel K Sia, Maria Gomes-Solecki
Currently, diagnostic testing for Lyme disease is done by determination of the serologic responses to Borrelia burgdorferi antigens, with the exception of the early localized phase of disease where diagnosis must be done clinically. Here, we describe the use of microfluidics technology to develop a multiplexed rapid lab-on-a-chip point of care (POC) assay for the serologic diagnosis of human Lyme disease. Following ELISA screening of 12 candidate antigens, we tested 8 on a microfluidic diagnostic system, called mChip-Ld, using a set of 60 serological samples...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27602780/nanoscale-electrochemical-sensor-arrays-redox-cycling-amplification-in-dual-electrode-systems
#11
Bernhard Wolfrum, Enno Kätelhön, Alexey Yakushenko, Kay J Krause, Nouran Adly, Martin Hüske, Philipp Rinklin
Micro- and nanofabriation technologies have a tremendous potential for the development of powerful sensor array platforms for electrochemical detection. The ability to integrate electrochemical sensor arrays with microfluidic devices nowadays provides possibilities for advanced lab-on-a-chip technology for the detection or quantification of multiple targets in a high-throughput approach. In particular, this is interesting for applications outside of analytical laboratories, such as point-of-care (POC) or on-site water screening where cost, measurement time, and the size of individual sensor devices are important factors to be considered...
September 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27536736/validation-of-the-genexpert%C3%A2-ct-ng-assay-for-use-with-male-pharyngeal-and-rectal-swabs
#12
R Geiger, D M Smith, S J Little, S R Mehta
OBJECTIVES: The GeneXpert(®) CT/NG (Cepheid, Sunnyvale, CA) assay is a point-of-care (POC) molecular diagnostic assay designed to rapidly test for the presence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC). However, the test is only approved for vaginal swabs, urine, and endocervical swabs. Here, we performed an evaluation of the GeneXpert(®) CT/NG assay to detect the presence of CT and GC on male pharyngeal and rectal swabs. METHODS: Men who have sex with men participating in an HIV and Sexually Transmitted Infection (STI) screening program providing consent were enrolled into the study...
2016: Austin Journal of HIV/AIDS Research
https://www.readbyqxmd.com/read/27508527/validation-of-the-accutrend-plus-point-of-care-triglyceride-analyzer-in-horses-ponies-and-donkeys
#13
Michaela C Pongratz, Hannah K Junge, Barbara Riond, Colin C Schwarzwald
OBJECTIVE: To assess the accuracy and reliability of a point-of-care (POC) triglyceride analyzer and to establish reference intervals for blood ([TRIG]POC/WB ) and plasma triglyceride concentrations ([TRIG]POC/PL ) in horses, ponies, and donkeys. DESIGN: Prospective study. SETTING: University teaching hospital. ANIMALS: 120 adult healthy equids (78 horses and ponies, 42 donkeys) and 79 equids suffering from hypertriglyceridemia (73 horses and ponies, 6 donkeys)...
September 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27429695/comparison-of-result-times-between-urine-and-whole-blood-point-of-care-pregnancy-testing
#14
Michael Gottlieb, Kristopher Wnek, Jordan Moskoff, Errick Christian, John Bailitz
INTRODUCTION: Point-of-care (POC) pregnancy testing is commonly performed in the emergency department (ED). One prior study demonstrated equivalent accuracy between urine and whole blood for one common brand of POC pregnancy testing. Our study sought to determine the difference in result times when comparing whole blood versus urine for the same brand of POC pregnancy testing. METHODS: We conducted a prospective, observational study at an urban, academic, tertiary care hospital comparing the turnaround time between order and result for urine and whole blood pregnancy tests collected according to standard protocol without intervention from the investigators...
July 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27406947/thirty-five-years-of-cd4-t-cell-counting-in-hiv-infection-from-flow-cytometry-in-the-lab-to-point-of-care-testing-in-the-field
#15
REVIEW
L Kestens, F Mandy
CD4 T-cell counting was introduced in clinical laboratories shortly after the discovery of the human immune deficiency virus (HIV) in the early eighties. In western clinical laboratories, improvements in the CD4 T-cell counting methods were mainly driven by progress in the field of flow cytometry and immunology. In contrast, the development of dedicated CD4 T-cell counting technologies were needs driven. When antiretroviral treatment (ART) was made available on a large scale by international Acquired Immune Deficiency Syndrome (AIDS) relief programs to HIV+ patients living in low income countries in 2003, there was a distinct need for simplified and affordable CD4 T-cell counting technologies...
July 12, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27380817/programmable-bio-nanochip-platform-a-point-of-care-biosensor-system-with-the-capacity-to-learn
#16
Michael P McRae, Glennon Simmons, Jorge Wong, John T McDevitt
The combination of point-of-care (POC) medical microdevices and machine learning has the potential transform the practice of medicine. In this area, scalable lab-on-a-chip (LOC) devices have many advantages over standard laboratory methods, including faster analysis, reduced cost, lower power consumption, and higher levels of integration and automation. Despite significant advances in LOC technologies over the years, several remaining obstacles are preventing clinical implementation and market penetration of these novel medical microdevices...
July 19, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27314345/spr-and-spr-imaging-recent-trends-in-developing-nanodevices-for-detection-and-real-time-monitoring-of-biomolecular-events
#17
REVIEW
Mihaela Puiu, Camelia Bala
In this paper we review the underlying principles of the surface plasmon resonance (SPR) technique, particularly emphasizing its advantages along with its limitations regarding the ability to discriminate between the specific binding response and the interfering effects from biological samples. While SPR sensors were developed almost three decades, SPR detection is not yet able to reduce the time-consuming steps of the analysis, and is hardly amenable for miniaturized, portable platforms required in point-of-care (POC) testing...
2016: Sensors
https://www.readbyqxmd.com/read/27304061/use-of-rapid-point-of-care-assays-by-private-practitioners-in-chennai-india-priorities-for-tuberculosis-diagnostic-testing
#18
Liza Bronner Murrison, Ramya Ananthakrishnan, Sumanya Sukumar, Sheela Augustine, Nalini Krishnan, Madhukar Pai, David W Dowdy
SETTING: Private practitioners are frequently the first point of healthcare contact for patients with tuberculosis (TB) in India. As new molecular tests are developed for point-of-care (POC) diagnosis of TB, it is imperative to understand these individuals' practices and preferences for POC testing. OBJECTIVE: To evaluate rapid testing practices and identify priorities for novel POC TB tests among private practitioners in Chennai. DESIGN: We conducted a cross-sectional survey of 228 practitioners practicing in the private sector from January 2014 to February 2015 who saw at least one TB patient in the previous year...
2016: PloS One
https://www.readbyqxmd.com/read/27179566/microfluidic-integrated-dna-nanobiosensors
#19
REVIEW
M I Haque Ansari, Shabir Hassan, Ahsanulhaq Qurashi, Firdous Ahmad Khanday
Over the last few decades, an increased demand has emerged for integrating biosensors with microfluidic- and nanofluidic-based lab-on-chip (LOC) devices for point-of-care (POC) diagnostics, in the medical industry and environmental monitoring of pathogenic threat agents. Such a merger of microfluidics with biosensing technologies allows for the precise control of volumes, as low as one nanolitre and the integration of various types of bioassays on a single miniaturized platform. This integration offers several favorable advantages, such as low reagent consumption, automation of sample preparation, reduction in processing time, low cost analysis, minimal handling of hazardous materials, high detection accuracy, portability and disposability...
November 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27103879/correction-of-point-of-care-inr-results-in-warfarin-patients
#20
Christopher Richter, James Taylor, Jonathan Shuster
BACKGROUND: The measurement of international normalization ratio (INR) may be done by venous blood draw and use of a standard lab, or by fingerstick, using a point of care (POC) device such as the CoaguChek XS(®) (Roche Diagnostics), and the CoaguChek XS(®) has been validated to meet the International Organization for Standardization (ISO) performance requirements. OVERVIEW: The goal of this study was to determine a correction factor for Coaguchek XS INR levels to a predicted venipuncture (VP) INR level...
March 2016: Point of Care
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