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Point of care

Nadia A Lustenberger, Birgit Prodinger, Delgerjargal Dorjbal, Sara Rubinelli, Klaus Schmitt, Anke Scheel-Sailer
PURPOSE: To illustrate how routinely written narrative admission and discharge reports of a rehabilitation program for eight youths with chronic neurological health conditions can be transformed to the International Classification of Functioning, Disability and Health. METHODS: First, a qualitative content analysis was conducted by building meaningful units with text segments assigned of the reports to the five elements of the Rehab-Cycle(®): goal; assessment; assignment; intervention; evaluation...
September 23, 2017: Disability and Rehabilitation
Min Su Kim, Soon Ho Kweon, Seongyeon Cho, Seong Soo A An, Moon Il Kim, Junsang Doh, Jinwoo Lee
Development of facile and sensitive bioassay is important for many point-of-care applications. In this study, we fulfilled such demand by synthesizing Pt-decorated magnetic nanozymes and developing a bioassay based on unique properties of the newly synthesized nanozymes. Fe3O4-Pt/Core-Shell nanoparticles (MPt/CS NPs) with various compositions were synthesized and characterized. Fe3O4 NP itself is a good nanozyme with catalytic activity superior to natural enzymes, but catalytic activity can be further improved by incorporating Pt to the outer layers of the Fe3O4 NPs and building heterogeneous nanostructures...
September 25, 2017: ACS Applied Materials & Interfaces
Kyung Sook Hong, Hee Jung Yi, Ryung-Ah Lee, Kwang Ho Kim, Soon Sup Chung
Fournier's gangrene is a gas-forming, necrotising soft tissue infection affecting the perineum. It spreads rapidly along the deep fascial planes and is associated with a high mortality rate. With a growing elderly population with comorbidities, the frequency of severe cases of Fournier's gangrene is expected to increase. We retrospectively reviewed 20 patients diagnosed with Fournier's gangrene at our institution from 2003 to 2014 and analysed data. Thirteen patients had diabetes mellitus, two had been diagnosed with liver cirrhosis, and four were chronic alcoholics...
September 25, 2017: International Wound Journal
Rajiv Sharma, Sarah Tinkler, Arnab Mitra, Sudeshna Pal, Raven Susu-Mago, Miron Stano
Medicaid and uninsured patients are disadvantaged in access to care and are disproportionately Black and Hispanic. Using a national audit of primary care physicians, we examine the relationship between state Medicaid fees for primary care services and access for Medicaid, Medicare, uninsured, and privately insured patients who differ by race/ethnicity and sex. We found that states with higher Medicaid fees had higher probabilities of appointment offers and shorter wait times for Medicaid patients, and lower probabilities of appointment offers and longer wait times for uninsured patients...
September 24, 2017: Health Economics
J M Burgette, J S Preisser, M Weinberger, R S King, R G Rozier
The objective of the study was to examine the mediating effect of child dental use on the effectiveness of North Carolina Early Head Start (EHS) in improving oral health-related quality of life (OHRQoL). In total, 479 parents of children enrolled in EHS and 699 parents of Medicaid-matched children were interviewed at baseline when children were approximately 10 mo old and 24 mo later. In this quasi-experimental study, mediation analysis was performed using the counterfactual framework analysis, which employed 2 logit models with random effects: 1) for the mediator as a function of the treatment and covariates and 2) for the outcome as a function of the treatment, mediator, and covariates...
October 2017: JDR Clinical and Translational Research
Stuart Farquharson, Kathryn Dana, Chetan Shende, Zachary Gladding, Jenelle Newcomb, Jessica Dascher, Ismene L Petrakis, Albert J Arias
Buprenorphine is becoming the medication of choice to help patients withdraw from opioid addiction. However, treatment is compromised by the inability of physicians to assess patient usage during scheduled examinations. Here we describe the development of a point-of-care (POC) analyzer that can rapidly measure both illicit and treatment drugs in patient saliva, ideally in the physician's office, and with a degree of accuracy similar to chromatography. The analyzer employs a relatively simple supported liquid extraction to isolate the drugs from the saliva and surface-enhanced Raman spectroscopy (SERS) to detect the drugs...
June 2017: Journal of Analytical & Bioanalytical Techniques
Jeffrey J Cies, Wayne S Moore, Adela Enache, Arun Chopra
OBJECTIVE: This study aims to describe the population pharmacokinetics and pharmacodynamic target attainment of meropenem in critically ill children. METHODS: The study involved a retrospective medical record review from a 189-bed, freestanding children's tertiary care teaching hospital of patients ages 1 to 9 years who received meropenem with concurrent therapeutic drug monitoring. RESULTS: There were 9 patients ages 1 to 9 years (mean age, 3...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Haowei Jiang, Alex Sun, A G Venkatesh, Drew A Hall
Portable and easy-to-use point-of-care (POC) diagnostic devices hold high promise for dramatically improving public health and wellness. In this paper, we present a mobile health (mHealth) immunoassay platform based on audio jack embedded devices, such as smartphones and laptops, that uses electrochemical impedance spectroscopy (EIS) to detect binding of target biomolecules. Compared to other biomolecular detection tools, this platform is intended to be used as a plug-and-play peripheral that reuses existing hardware in the mobile device and does not require an external battery, thereby improving upon its convenience and portability...
February 1, 2017: IEEE Sensors Journal
Seiichi Kobayashi, Hanagama Masakazu, Masaru Yanai
Objective To evaluate the effectiveness of an early detection program for chronic obstructive pulmonary disease (COPD) in a primary care setting in Japan. Methods Participants of ≥40 years of age who regularly visited a general practitioner's clinic due to chronic disease were asked to complete a COPD screening questionnaire (COPD Population Screener; COPD-PS) and undergo simplified spirometry using a handheld spirometric device. Patients who showed possible COPD were referred to a respiratory specialist and underwent a detailed examination that included spirometry and chest radiography...
September 25, 2017: Internal Medicine
Darragh Duffy, Vincent Rouilly, Cecile Braudeau, Véronique Corbière, Raouf Djebali, Marie-Noelle Ungeheuer, Regis Josien, Sam LaBrie, Olivier Lantz, Delphine Louis, Eva Martinez-Caceres, Francoise Mascart, Jose G Ruiz de Morales, Catherine Ottone, Lydia Redjah, Nina Salabert-Le Guen, Alain Savenay, Manfred Schmolz, Antoine Toubert, Matthew L Albert
Functional immune responses are increasingly important for clinical studies, providing in depth biomarker information to assess immunotherapy or vaccination. Incorporating functional immune assays into routine clinical practice has remained limited due to challenges in standardizing sample preparation. We recently described the use of a whole blood syringe-based system, TruCulture®, which permits point-of-care standardized immune stimulation. Here, we report on a multi-center clinical study in seven FOCIS Centers of Excellence to directly compare TruCulture to conventional PBMC methods...
September 21, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
E Mill-Ferreyra, V Cameno-Carrillo, H Saúl-Gordo, M C Camí-Lavado
INTRODUCTION: Many patients are affected by various conditions, which make it impossible to calculate body mass index (BMI) by measuring weight and height. For this reason, the purpose of this study was to develop a mathematical tool that allows the approximate calculation of the brachial circumference for diagnosis and follow-up. The formula proposed for both sexes is: brachial circumference (cm)×30/32. Results≥28 must be added 2 points. MATERIAL AND METHODS: Prospective, descriptive, observational study performed in a primary care clinic, including 224 men and 248 women...
September 21, 2017: Semergen
Yihua Bruce Yu, Marc B Taraban, Weizhen Wang, Katharine T Briggs
Biopharmaceuticals and small-molecule drugs have different approval pathways but the same quality control (QC) paradigm, where the quality of released but untested units is inferred from that of tested but destroyed units. This inference-based QC will likely miss rare prerelease defects, and defects emerging after product release. The likelihood for such defects is heightened for biopharmaceuticals due to their complexity, which makes manufacturing errors more likely, and fragility, which makes postrelease damage more likely...
September 21, 2017: Trends in Biotechnology
Sean Robinson Smith, Ashish Khanna, Eric M Wisotzky
Lung cancer is the number one cause of cancer-related death worldwide, and is often detected in the later stages. Use of low-dose chest computed tomography in at-risk patients provides earlier detection and is being adopted as the standard screening tool, replacing less precise methods of radiography and sputum cytology. In the past, late detection of disease meant that rehabilitation interventions attempted to salvage function and to improve aerobic capacity to the point where patients could tolerate the sometimes-extensive oncologic treatment, including lobectomy or pneumonectomy...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
M J Spittal, S Forsyth, R Borschmann, J T Young, S A Kinner
AIM: People released from prison are at higher risk of mortality from potentially preventable causes than their peers in the general population. Because most studies of this phenomenon are reliant on registry data, there is little health and behavioural information available on those at risk, hampering the development of targeted, evidence-based preventive responses. Our aim was to identify modifiable risk and protective factors for external cause and cause-specific mortality after release from prison...
September 25, 2017: Epidemiology and Psychiatric Sciences
Serena Cheng, Nadia I Awad, Kathleen C Toomey, Zinasia Gibson, Venai Chari, Luigi Brunetti
Background The Food and Drug Administration issued a drug safety alert highlighting the potential association of docetaxel infusion with signs and symptoms of alcohol intoxication. This concern is significant because patients treated with docetaxel often have comorbidities and are prescribed concomitant centrally active medications. As a result, these patients may be at risk for iatrogenic events. Objective The objective of this study was to identify a correlation with docetaxel infusion and saliva ethanol concentration using a point-of-care ethanol test...
January 1, 2017: Journal of Oncology Pharmacy Practice
Menne Bartelsman, Kelsey Vaughan, Martijn S van Rooijen, Henry J C de Vries, Maria Xiridou
OBJECTIVE: Point-of-care (POC) management may avert ongoing transmissions occurring between testing and treatment or due to loss to follow-up. We modelled the impact of POC management of anogenital gonorrhoea (with light microscopic evaluation of Gram stained smears) among men who have sex with men (MSM) on gonorrhoea prevalence and testing and treatment costs. METHODS: Data concerning costs and sexual behaviour were collected from the STI clinic of Amsterdam. With a deterministic model for gonorrhoea transmission, we calculated the prevalence of gonorrhoea in MSM in Amsterdam and the numbers of consultations at our clinic over 5 years, in three testing scenarios: POC for symptomatic MSM only (currently routine), POC for all MSM and no POC for MSM...
September 23, 2017: Sexually Transmitted Infections
Jiantong Dong, Tongbo Wu, Yu Xiao, Lu Chen, Lei Xu, Mengyuan Li, Meiping Zhao
Nucleoside triphosphates (NTPs) play important roles in living organisms. However, no fluorescent assays are currently available to simply and rapidly detect multiple NTPs with satisfactory selectivity, sensitivity and low cost. Here we demonstrate for the first time a target-triggered in-vitro transcription machinery for ultra-selective, sensitive and instant fluorescence detection of multiple NTPs. The machinery assembles RNA polymerase, DNA template and non-target NTPs to convert the target NTP into equivalent RNA signal sequences which are monitored by the fluorescence enhancement of molecular beacon...
September 19, 2017: Biosensors & Bioelectronics
Indu Sarangadharan, Abiral Regmi, Yen-Wen Chen, Chen-Pin Hsu, Pei-Chi Chen, Wen-Hsin Chang, Geng-Yen Lee, Jen-Inn Chyi, Shu-Chu Shiesh, Gwo-Bin Lee, Yu-Lin Wang
In this study, we report the development of a high sensitivity assay for the detection of cardiac troponin I using electrical double layer gated high field AlGaN/GaN HEMT biosensor. The unique gating mechanism overcomes the drawback of charge screening seen in traditional FET based biosensors, allowing detection of target proteins in physiological solutions without sample processing steps. Troponin I specific antibody and aptamer are used as receptors. The tests carried out using purified protein solution and clinical serum samples depict high sensitivity, specificity and wide dynamic range (0...
September 14, 2017: Biosensors & Bioelectronics
Frederico Castro Costa Póvoa, Pablo Cardinal-Fernandez, Israel Silva Maia, Maycon Moura Reboredo, Bruno Valle Pinheiro
PURPOSE: We evaluated the effect of antibiotics administered via the respiratory tract to prevent the ventilator-associated pneumonia (VAP) in mechanically ventilated (MV) patients. METHODS: We searched relevant articles for trials that evaluated the impact of prophylactic antibiotics administered through the respiratory tract on the occurrence of VAP. The end-point was the occurrence of VAP in MV patients. RESULTS: We included 6 comparative trials involving 1158 patients (632 received prophylactic antibiotic)...
September 18, 2017: Journal of Critical Care
Boh Boi Wong, Yiong Huak Chan, Mabel Qi He Leow, Yi Lu, Yap Seng Chong, Serena Siew Lin Koh, Hong-Gu He
BACKGROUND: The effects of cold cabbage leaves and cold gel packs on breast engorgement management have been inconclusive. No studies have compared the effects of these methods on breast engorgement using a rigorous design. OBJECTIVES: To examine the effectiveness of cold cabbage leaves and cold gel packs application on pain, hardness, and temperature due to breast engorgement, the duration of breastfeeding and satisfaction. DESIGN: A randomised controlled three-group pre-test and repeated post-test study...
August 31, 2017: International Journal of Nursing Studies
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