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CX3CL1

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https://www.readbyqxmd.com/read/27896922/-epigallocatechin-3-gallate-antihyperalgesic-effect-associates-with-reduced-cx3cl1-chemokine-expression-in-spinal-cord
#1
Marc Bosch-Mola, Judit Homs, Beltrán Álvarez-Pérez, Teresa Puig, Francisco Reina, Enrique Verdú, Pere Boadas-Vaello
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation in animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during neuropathic pain development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia in chronic constriction injured mice. To this end, Balb/c mice were subjected to a chronic constriction injury of sciatic nerve (CCI) and treated with EGCG or vehicle once a day during the first week following surgery...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27895167/pgi2-controls-pulmonary-nk-cells-that-prevent-airway-sensitization-to-house-dust-mite-allergen
#2
Bryan Simons, Maria E Ferrini, Sophia Carvalho, David J P Bassett, Zeina Jaffar, Kevan Roberts
In allergic asthma, inhalation of airborne allergens such as the house dust mite (HDM) effectively activates both innate and adaptive immunity in the lung mucosa. To determine the role of the eicosanoid PGI2 and its receptor IP during allergic airway sensitization, HDM responses in mice lacking a functional IP receptor (i.e., PGI2 IP receptor-deficient [IP(-/-)]) were compared with wild type (WT) mice. Surprisingly, IP(-/-) mice had increased numbers of pulmonary CD3(-)NK1.1(+)Ly49b(+) NK cells producing IFN-γ that was inversely associated with the number of type 2 innate lymphoid cells (ILC2s) expressing IL-33Rα and IL-13 compared with WT animals...
November 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27893098/vitreal-cytokine-profile-differences-between-eyes-with-epiretinal-membranes-or-macular-holes
#3
Souska Zandi, Christoph Tappeiner, Isabel B Pfister, Alain Despont, Robert Rieben, Justus G Garweg
Purpose: Cytokines play an important role in cell signaling in inflammatory and repair processes, also within the posterior segment of the eye. These molecules are thus implicated in the pathophysiology of several vitreoretinal diseases. In the present study, we compared vitreal cytokine profiles in patients with idiopathic epiretinal membranes (ERMs) and idiopathic full-thickness macular holes (MHs) without epiretinal membranes. Methods: Native vitreal humor was collected during elective pars plana vitrectomy for the treatment of macular pathologies (group 1: ERM; group 2: MH) from patients without any other ocular or systemic disease...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27891323/reduced-cx3cl1-secretion-contributes-to-the-susceptibility-of-oral-leukoplakia-associated-fibroblasts-to-candida-albicans
#4
Ran Cheng, Duo Li, Xueke Shi, Qinghong Gao, Changlei Wei, Xiaoyu Li, Yan Li, Hongmei Zhou
Candida leukoplakia (OLK) is a kind of oral leukoplakia combined with chronic candidal infection, which plays an important role in the malignant transformation of OLK. However, little is known about the etiology, including susceptibility of leukoplakia to candidal adhesion, invasion and infection. Some antimicrobial peptides secreted by oral epithelial cells or fibroblasts potentially have antifungal activities against Candida albicans (C. albicans). In this study, we established three co-culture models to simulate different C...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27873479/cytokine-and-chemokine-tear-levels-in-patients-with-uveitis
#5
Ester Carreño, Alejandro Portero, José M Herreras, Carmen García-Vázquez, Scott M Whitcup, Michael E Stern, Margarita Calonge, Amalia Enríquez-de-Salamanca
PURPOSE: To determine whether the levels of cytokines and chemokines in tears differ in uveitis patients and healthy subjects. METHODS: Ninety-two uveitis patients (mean age 46.4 years) and 157 control healthy subjects (mean age 49.5 years) were recruited. Subjects with ocular surface diseases such as dry eye were excluded from the study. Using multiplex bead-based assays, tears (4 μl) were analysed for the concentration of interleukin (IL)-1β, IL-1RA, IL-2, IL-6, IL-7, IL-8/CXCL8, IL-10, IL-12p70, IL-15, IL-17A, IL-23, epidermal growth factor (EGF), fractalkine/CX3CL1, interferon-γ, IP-10/CXCL10, monocyte chemo-attractant protein (MCP)-1/CCL2, tumour necrosis factor-α, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, TGF-β2 and TGF-β3...
November 22, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27846745/a-disintegrin-and-metalloproteinase-adam-10-as-a-predictive-factor-for-tocilizumab-effectiveness-in-rheumatoid-arthritis
#6
Takeo Isozaki, Shinichiro Nishimi, Airi Nishimi, Mayu Saito, Yusuke Miwa, Yoichi Toyoshima, Katsunori Inagaki, Tsuyoshi Kasama
OBJECTIVES: A disintegrin and metalloproteinase (ADAM)-10 is expressed in rheumatoid arthritis (RA). In this study, we focused on ADAM-10 as predictive factor for treatment with biologics in RA. METHODS: The levels of ADAM-10 and fractalkine/CX3CL1 in RA and healthy controls serum were measured with enzyme-linked immunosorbent assays. Fifteen patients were treated with adalimumab (ADA), and 20 patients were treated with tocilizumab (TCZ). RESULTS: ADAM-10 positively correlated with fractalkine/CX3CL1 in the sera of RA patients and was present at a significantly higher level compared to that in normal serum (487±80 pg/ml and 85±33 pg/ml, respectively, p < 0...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27837169/ccr2-regulates-inflammatory-cell-accumulation-in-the-lung-and-tissue-injury-following-ozone-exposure
#7
Mary Francis, Angela Groves, Richard Sun, Jessica A Cervelli, Hyejeong Choi, Jeffrey D Laskin, Debra L Laskin
Ozone-induced lung injury is associated with an accumulation of activated macrophages in the lung. Chemokine receptor CCR2 mediates the migration of inflammatory monocytes/macrophages to sites of tissue injury. It is also required for monocyte egress from the bone marrow. In the present studies, we analyzed the role of CCR2 in inflammatory cell trafficking to the lung in response to ozone. Treatment of mice with ozone (0.8 ppm, 3 h) resulted in increases in pro-inflammatory CCR2(+) macrophages in the lung at 24 h, as well as pro-inflammatory CD11b(+)Ly6C(Hi) and iNOS(+) macrophages at 24 h and 48 h...
November 11, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27821234/-expression-and-function-of-fractalkine-and-its-receptor-in-5xfad-mouse
#8
L Q Chu, Y Lu, B Karen, J Xu, Q Liu, Quan Zhou
Objective: To detect the expression and the function of Fractalkine(CX3CL1) and its receptor CX3CR1 in neurodegenerative changes of the retina. Methods: Twelve 5XFAD mouse and twelve wild type mouse were enrolled. Frozen sections were prepared for histopathological tests. Immunofluorescence study for Amyloid β, CX3CL1 and CX3CR1 was carried out. Co-expression study for CX3CR1/CD11b or CX3CR1/CD68 was carried out. Total protein and total mRNA from the eyes of both 5XFAD and wild type mouse were extracted. The expression of mRNA and protein of CX3CL1 and CX3CR1 in the eyes were determined by reverse transcription-polymerase chain reaction (RT-PCR) and Western blots test, respectively...
November 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27752937/fractalkine-in-obstructive-sleep-apnea-patients
#9
Gulgun Cetintas Afsar, Ozlem Oruc, Sema Sarac, Özgür Bilgin Topçuoğlu, Cuneyt Salturk, Fatma Merve Tepetam, Ismet Bulut
BACKGROUND: Obstructive sleep apnea (OSA) is the most common sleep disorder affecting 2-4 % of the adult population. In addition to several potential mechanisms, inflammation is one of the suggested etiological factors in OSA. Fractalkine/CX3CL1 which is detected in activated or stressed endothelium, smooth muscle cells, skeletal muscle cells, macrophages, neurons, and hepatocytes is an inflammatory marker and attracts attention of sleep specialists in OSA pathogenesis. In this study, we had two goals...
October 17, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27748636/influence-of-5-amino-3-methyl-4-isoxazolecarbohydrazide-on-selective-gene-expression-in-caco-2-cultured-cells
#10
Paulina Płoszaj, Andrzej Regiec, Stanisław Ryng, Agnieszka Piwowar, Marian L Kruzel
The 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide (HIX) is a synthetic isoxazole derivative with a potential for development as an anti-inflammatory drug candidate. The goal of this study was to explore in vitro autoimmune and inflammatory gene modulation by HIX in human Caco-2 cultured cells. The effect of low dose of HIX was tested on the expression level of RNA in 24h Caco-2 cultures using the QIAGEN Th17 for Autoimmunity & Inflammation RT(2) Profiler PCR Array. We choose the PCR technology as the most reliable and sensitive gene expression profiling method for analyzing specific gene regulatory networks...
October 17, 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27692539/macrophage-monocyte-specific-deletion-of-ras-homolog-gene-family-member-a-rhoa-downregulates-fractalkine-receptor-and-inhibits-chronic-rejection-of-mouse-cardiac-allografts
#11
Yianzhu Liu, Wenhao Chen, Chenglin Wu, Laurie J Minze, Jacek Z Kubiak, Xian C Li, Malgorzata Kloc, Rafik M Ghobrial
BACKGROUND: The cellular and molecular mechanisms of chronic rejection of transplanted organs remain obscure; however, macrophages are known to play a critical role in the injury and repair of allografts. Among multiple factors influencing macrophage infiltration to allografts, the fractalkine chemokine (C-X3-C motif) ligand 1(CX3CL1)/chemokine (C-X3-C motif) receptor 1 (CX3CR1) signaling pathway and actin cytoskeleton, which is regulated by a small guanosine-5׳-triphosphatase Ras homolog gene family member A (RhoA), are of the utmost importance...
August 20, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27687148/cathepsin-s-contributes-to-microglia-mediated-olfactory-dysfunction-through-the-regulation-of-cx3cl1-cx3cr1-axis-in-a-niemann-pick-disease-type-c1-model
#12
Yoojin Seo, Hyung-Sik Kim, Insung Kang, Soon Won Choi, Tae-Hoon Shin, Ji-Hee Shin, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Myung Geun Kook, Kyung-Sun Kang
Microglia can aggravate olfactory dysfunction by mediating neuronal death in the olfactory bulb (OB) of a murine model of Niemann-Pick disease type C1 (NPC1), a fatal neurodegenerative disorder accompanied by lipid trafficking defects. In this study, we focused on the crosstalk between neurons and microglia to elucidate the mechanisms underlying extensive microgliosis in the NPC1-affected brain. Microglia in the OB of NPC1 mice strongly expressed CX3C chemokine receptor 1 (Cx3cr1), a specific receptor for the neural chemokine C-X3-C motif ligand 1 (Cx3cl1)...
December 2016: Glia
https://www.readbyqxmd.com/read/27658415/assessment-of-serum-cx3cl1-fractalkine-level-in-han-chinese-girls-with-anorexia-nervosa-and-its-correlation-with-nutritional-status-a-preliminary-cross-sectional-study
#13
Shengkang Zhang, Hanfeng Tang, Cai Gong, Jiang Liu, Jindong Chen
The chemokine (C-X3-C motif) ligand 1 (CX3CL1), also named fractalkine (FKN), has been implicated in psychiatric disorders and functions as a novel adipocytokine. However, no attention has been paid to the role of FKN in anorexia nervosa (AN). The current study was performed to explore FKN levels in AN to determine its role in the involvement of AN. A total of 96 girls aged 11-18 years with AN (n=34), healthy controls (HC; n=32) and simple obesity (OB, n=30) were enrolled in the cross-sectional study. Blood samples were collected during the fasting state...
September 22, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27646532/spinal-microglial-activation-in-a-murine-surgical-model-of-knee-osteoarthritis
#14
P B Tran, R E Miller, S Ishihara, R J Miller, A M Malfait
OBJECTIVE: Microgliosis, the activation of microglial cells, is thought to contribute to synaptic transmission in the dorsal horn and thereby promote chronic pain. The primary aim of this study was to document the temporal profile of dorsal horn microgliosis after destabilization of the medial meniscus (DMM) in wild type (WT) and Adamts5 null mice. Since neuronal fractalkine (CX3CL1) contributes to microgliosis, we assessed its release from dorsal root ganglia (DRG) cultures after DMM...
September 16, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27639555/microglial-cx3cr1-promotes-adult-neurogenesis-by-inhibiting-sirt-1-p65-signaling-independent-of-cx3cl1
#15
Sabine Sellner, Ricardo Paricio-Montesinos, Alena Spieß, Annette Masuch, Daniel Erny, Laura A Harsan, Dominik V Elverfeldt, Marius Schwabenland, Knut Biber, Ori Staszewski, Sergio Lira, Steffen Jung, Marco Prinz, Thomas Blank
Homo and heterozygote cx3cr1 mutant mice, which harbor a green fluorescent protein (EGFP) in their cx3cr1 loci, represent a widely used animal model to study microglia and peripheral myeloid cells. Here we report that microglia in the dentate gyrus (DG) of cx3cr1 (-/-) mice displayed elevated microglial sirtuin 1 (SIRT1) expression levels and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) p65 activation, despite unaltered morphology when compared to cx3cr1 (+/-) or cx3cr1 (+/+) controls...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27607600/association-study-between-promoter-polymorphisms-of-adam17-and-progression-of-sepsis
#16
Yiming Shao, Junbing He, Feng Chen, Yujie Cai, Jianghao Zhao, Yao Lin, Zihan Yin, Hua Tao, Xin Shao, Pengru Huang, Mingkang Yin, Wenying Zhang, Zhou Liu, Lili Cui
BACKGROUND: A disintegrin and metalloproteinase 17 (ADAM17) has been confirmed to play a significant role in the pathogenesis of sepsis. However, little is known about the clinical relevance of ADAM17 polymorphisms to sepsis onset and development. METHODS: This study analyzed the associations of five ADAM17 promoter polymorphisms (rs55790676, rs12692386, rs11684747, rs1524668 and rs11689958) with sepsis (370 sepsis cases and 400 controls). Genotyping was performed using pyrosequencing and polymerase chain reaction-length polymorphism method...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27579490/involvement-of-cx3cl1-in-the-migration-of-osteoclast-precursors-across-osteoblast-layer-stimulated-by-interleukin-1%C3%A3
#17
Tsuyoshi Matsuura, Shizuko Ichinose, Masako Akiyama, Yuki Kasahara, Noriko Tachikawa, Ken-Ichi Nakahama
The trigger for bone remodeling is bone resorption by osteoclasts. Osteoclast differentiation only occurs on the old bone, which needs to be repaired under physiological conditions. However, uncontrolled bone resorption is often observed in pro-inflammatory bone diseases, such as rheumatoid arthritis. Mature osteoclasts are multinuclear cells that differentiate from monocyte/macrophage lineage cells by cell fusion. Although Osteoclast precursors should migrate across osteoblast layer to reach bone matrix before maturation, the underlying mechanisms have not yet been elucidated in detail...
August 31, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27571927/atezolizumab-in-combination-with-bevacizumab-enhances-antigen-specific-t-cell-migration-in-metastatic-renal-cell-carcinoma
#18
Jeffrey J Wallin, Johanna C Bendell, Roel Funke, Mario Sznol, Konstanty Korski, Suzanne Jones, Genevive Hernandez, James Mier, Xian He, F Stephen Hodi, Mitchell Denker, Vincent Leveque, Marta Cañamero, Galina Babitski, Hartmut Koeppen, James Ziai, Neeraj Sharma, Fabien Gaire, Daniel S Chen, Daniel Waterkamp, Priti S Hegde, David F McDermott
Anti-tumour immune activation by checkpoint inhibitors leads to durable responses in a variety of cancers, but combination approaches are required to extend this benefit beyond a subset of patients. In preclinical models tumour-derived VEGF limits immune cell activity while anti-VEGF augments intra-tumoral T-cell infiltration, potentially through vascular normalization and endothelial cell activation. This study investigates how VEGF blockade with bevacizumab could potentiate PD-L1 checkpoint inhibition with atezolizumab in mRCC...
August 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27569723/combination-of-mass-cytometry-and-imaging-analysis-reveals%C3%A2-origin-location-and-functional-repopulation-of%C3%A2-liver%C3%A2-myeloid-cells-in-mice
#19
Bruna Araujo David, Rafael Machado Rezende, Maísa Mota Antunes, Mônica Morais Santos, Maria Alice Freitas Lopes, Ariane Barros Diniz, Rafaela Vaz Sousa Pereira, Sarah Cozzer Marchesi, Débora Moreira Alvarenga, Brenda Naemi Nakagaki, Alan Moreira Araújo, Daniela Silva Dos Reis, Renata Monti Rocha, Pedro Elias Marques, Woo-Yong Lee, Justin Deniset, Pei Xiong Liew, Stephen Rubino, Laura Cox, Vanessa Pinho, Thiago Mattar Cunha, Gabriel Rocha Fernandes, André Gustavo Oliveira, Mauro Martins Teixeira, Paul Kubes, Gustavo Batista Menezes
BACKGROUND & AIMS: Resident macrophages are derived from yolk sac precursors and seed the liver during embryogenesis. Native cells may be replaced by bone marrow precursors during extensive injuries, irradiation, and infections. We investigated the liver populations of myeloid immune cells and their location, as well as the dynamics of phagocyte repopulation after full depletion. The effects on liver function due to the substitution of original phagocytes by bone marrow-derived surrogates were also examined...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27549131/fractalkine-shedding-is-mediated-by-p38-and-the-adam10-protease-under-pro-inflammatory-conditions-in-human-astrocytes
#20
Sinead A O'Sullivan, Fabrizio Gasparini, Anis K Mir, Kumlesh K Dev
BACKGROUND: The fractalkine (CX3CR1) ligand is expressed in astrocytes and reported to be neuroprotective. When cleaved from the membrane, soluble fractalkine (sCX3CL1) activates the receptor CX3CR1. Although somewhat controversial, CX3CR1 is reported to be expressed in neurons and microglia. The membrane-bound form of CX3CL1 additionally acts as an adhesion molecule for microglia and infiltrating white blood cells. Much research has been done on the role of fractalkine in neuronal cells; however, little is known about the regulation of the CX3CL1 ligand in astrocytes...
2016: Journal of Neuroinflammation
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