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Tom van den Ende, Sarvi Sharifi, Sandra M A van der Salm, Anne-Fleur van Rootselaar
Background: Autosomal dominant familial cortical myoclonic tremor and epilepsy (FCMTE) is characterized by distal tremulous myoclonus, generalized seizures, and signs of cortical reflex myoclonus. FCMTE has been described in over 100 pedigrees worldwide, under several different names and acronyms. Pathological changes have been located in the cerebellum. This systematic review discusses the clinical spectrum, treatment, pathophysiology, and genetic findings. Methods: We carried out a PubMed search, using a combination of the following search terms: cortical tremor, myoclonus, epilepsy, benign course, adult onset, familial, and autosomal dominant; this resulted in a total of 77 studies (761 patients; 126 pedigrees) fulfilling the inclusion and exclusion criteria...
2018: Tremor and Other Hyperkinetic Movements
Anne-Fleur van Rootselaar, Alexander J Groffen, Boukje de Vries, Petra M C Callenbach, Gijs W E Santen, Stephany Koelewijn, Lisanne S Vijfhuizen, Arthur Buijink, Marina A J Tijssen, Arn M J M van den Maagdenberg
OBJECTIVE: To identify the causative gene in a large Dutch family with familial cortical myoclonic tremor and epilepsy (FCMTE). METHODS: We performed exome sequencing for 3 patients of our FCMTE family. Next, we performed knock-down (shRNA) and rescue experiments by overexpressing wild-type and mutant human δ-catenin (CTNND2) proteins in cortical mouse neurons and compared the results with morphologic abnormalities in the postmortem FCMTE brain. RESULTS: We identified a missense mutation, p...
December 5, 2017: Neurology
Riaan van Coller, Anne-Fleur van Rootselaar, Clara Schutte, C H van der Meyden
AIM: The aims of this study were to report the index case of a South African family with cortical myoclonic tremor and epilepsy, to describe the pedigree with the clinical findings and results of additional investigations, and to report the unique follow-up evaluation of affected and unaffected family members after 30 years. METHODS: The index case led to evaluation of the clinical files of patients from 1978/1979 and clinical assessment and investigation of patients from this cohort as well as newly identified family members...
May 2017: Parkinsonism & related Disorders
Lehong Gao, Liping Li, Jing Ye, Xilin Zhu, Ning Shen, Xiating Zhang, Dequan Wang, Yu Gao, Hua Lin, Yuping Wang, Ying Liu
PURPOSE: Familial cortical myoclonic tremor with epilepsy (FCMTE) is an epileptic syndrome with autosomal dominant inheritance, of which four genetic subtypes (FCMTE1-4) have been reported. In the present study, we described the clinical and neurophysiologic features of a newly diagnosed Chinese FCMTE family, and investigated the genetic cause for this disease. METHODS: Clinical information was obtained from affected and normal individuals of an FCMTE family comprising 41 members...
October 2016: Seizure: the Journal of the British Epilepsy Association
A W G Buijink, M Broersma, A M M van der Stouwe, S Sharifi, M A J Tijssen, J D Speelman, N M Maurits, A F van Rootselaar
Essential tremor (ET) presumably has a cerebellar origin. Imaging studies showed various cerebellar and also cortical structural changes. A number of pathology studies indicated cerebellar Purkinje cell pathology. ET is a heterogeneous disorder, possibly indicating different underlying disease mechanisms. Familial cortical myoclonic tremor with epilepsy (FCMTE), with evident Purkinje cell degeneration, can be an ET mimic. Here, we investigate whole brain and, more specifically, cerebellar morphological changes in hereditary ET, FCMTE, and healthy controls...
December 2016: Cerebellum
Zhi-Dong Cen, Fei Xie, Dan-Ning Lou, Xing-Jiao Lu, Zhi-Yuan Ouyang, Ling Liu, Jin Cao, Dan Li, Hou-Min Yin, Zhong-Jin Wang, Jian-Feng Xiao, Wei Luo
Familial cortical myoclonic tremor with epilepsy (FCMTE) is an autosomal dominant epilepsy syndrome. Four loci, including 8q24 (FCMTE1), 2p11.1-q12.2 (FCMTE2), 5p15.31-p15.1 (FCMTE3), and 3q26.32-3q28 (FCMTE4) were previously reported. Herein, we report a new FCMTE1 pedigree from Chinese population with its clinical and genetic study results. Whole genome scan was performed to identify the causative gene region and copy number variants. Whole-exome sequencing was used to identify the causative gene. There were twelve affected members alive in this FCMTE1 pedigree...
October 2015: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Caixia Liu, Wei Sun, Qiuhui Chen, Jia Li, Guohua Hu
AIM: In this study, we genotyped eight microsatellite markers on chromosome 5 and performed linkage analyses. We aimed to establish the pathogenic gene loci in this familial cortical myoclonic tremor with epilepsy (FCMTE) pedigree. MATERIALS AND METHODS: Reliable clinical information was obtained on the Chinese family members. Our study performed linkage analysis across these loci to identify and further characterize the pathogenic gene locus underlying FCMTE in Chinese patients...
March 2015: Neurology India
Pu Wang, Cheng Luo, Li Dong, Yi Bin, Shi Ma, Dezhong Yao, Fuqiang Guo, Zhenglin Yang
PURPOSE: To investigate localized cerebral function abnormalities in patients with familial cortical myoclonic tremor and epilepsy (FCMTE) using resting-state functional magnetic resonance imaging (fMRI). METHODS: Seven patients with FCMTE from a Chinese family, seven patients with essential tremor (ET), and ten healthy controls were recruited. Amplitude of low-frequency fluctuation (ALFF) analysis was utilized to reveal the potential functional changes in patients with FCMTE...
April 15, 2015: Journal of the Neurological Sciences
Jose Felix Martí-Massó, Alberto Bergareche, Vladimir Makarov, Javier Ruiz-Martinez, Ana Gorostidi, Adolfo López de Munain, Juan Jose Poza, Pasquale Striano, Joseph D Buxbaum, Coro Paisán-Ruiz
UNLABELLED: Familial cortical myoclonic tremor and epilepsy is a phenotypically and genetically heterogeneous autosomal dominant disorder characterized by the presence of cortical myoclonic tremor and epilepsy that is often accompanied by additional neurological features. Despite the numerous familial studies performed and the number of loci identified, there is no gene associated with this syndrome. It is expected that through the application of novel genomic technologies, such as whole exome sequencing and whole genome sequencing, a substantial number of novel genes will come to light in the coming years...
December 2013: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Laura Licchetta, Tommaso Pippucci, Francesca Bisulli, Gaetano Cantalupo, Pamela Magini, Lara Alvisi, Sara Baldassari, Paolo Martinelli, Ilaria Naldi, Nicola Vanni, Rocco Liguori, Marco Seri, Paolo Tinuper
PURPOSE: We describe the clinical, neurophysiologic, and genetic features of a new, large family with familial cortical myoclonic tremor and epilepsy (FCMTE). METHODS: Reliable clinical information was obtained on the 127 members. Thirty-one collaborative individuals were assessed by a detailed clinical interview and a complete neurologic examination. A polygraphic study was conducted in 15 patients, back-averaging analysis and somatosensory evoked potentials with C-reflex study in four...
July 2013: Epilepsia
Arthur W G Buijink, Matthan W A Caan, Marina A J Tijssen, Johannes M Hoogduin, Natasha M Maurits, Anne-Fleur van Rootselaar
Pathophysiology of tremor generation remains uncertain in 'familial cortical myoclonic tremor with epilepsy' (FCMTE) and essential tremor (ET). In both disorders, imaging and pathological studies suggest involvement of the cerebellum and its projection areas. MR diffusion tensor imaging allows estimation of white matter tissue composition, and therefore is well suited to quantify structural changes in vivo. This study aimed to compare cerebellar fiber density between FCMTE and ET patients and healthy controls...
April 2013: Cerebellum
C Depienne, E Magnin, D Bouteiller, G Stevanin, C Saint-Martin, M Vidailhet, E Apartis, E Hirsch, E LeGuern, P Labauge, L Rumbach
BACKGROUND: Familial cortical myoclonic tremor with epilepsy (FCMTE) is defined by autosomal dominant adult-onset cortical myoclonus (CM) and seizures in 40% of patients. Two loci, 8q23.3-q24.11 (FAME1/FCMTE1) and 2p11.1-q12.2 (FAME2/FCMTE2), were previously reported without an identified gene. Unlinked families argue for a third mutated gene. METHODS: A genome-wide scan was performed in a large FCMTE family using Linkage-12 microarrays (Illumina). Refinement of the locus on 5p was performed by genotyping 13 polymorphic microsatellite markers in the 45 available family members...
June 15, 2010: Neurology
E Magnin, M Vidailhet, C Depienne, C Saint-Martin, D Bouteiller, E LeGuern, E Apartis, L Rumbach, P Labauge
INTRODUCTION: Familial cortical myoclonic tremor with epilepsy (FCMTE) is defined by an autosomal-dominant inheritance, adult onset of myoclonus of the extremities, infrequent epileptic seizures, a non-progressive course, polyspikes on electroencephalography (EEG), photosensitivity, giant somatosensory-evoked potentials (SEP), enhancement of C-reflex and a premyoclonus spike detected by jerk-locked EEG back-averaging. Two genes yet to be identified are mapped to 8q23.3-q24.1 and 2p11...
October 2009: Revue Neurologique
Antonio Suppa, Alfredo Berardelli, Francesco Brancati, Massimo Marianetti, Giuseppe Barrano, Concetta Mina, Antonio Pizzuti, Giulio Sideri
We studied the clinical, neuropsychological, neurophysiologic, and genetic features of an Italian family with familial cortical myoclonic tremor with epilepsy (FCMTE). Clinically affected members of the family had limb and voice tremor, seizures, and myoclonus involving the eyelids during blinking. Neuropsychological testing disclosed visuospatial impairment, possibly due to temporal lobe dysfunction. Neurophysiologic findings suggested increased primary motor cortex excitability with normal sensorimotor integration...
May 2009: Epilepsia
L J Bour, A F van Rootselaar, J H T M Koelman, M A J Tijssen
In the present study, eye movements are recorded in two patient groups with an autosomal dominantly inherited cerebellar disorder, i.e. spinocerebellar ataxia type 6 (SCA6) and familial cortical myoclonic tremor with epilepsy (FCMTE). In SCA6 and FCMTE patients striking similarities with the extensive Purkinje cell changes in the cerebellar cortex were described, but the two disorders have a distinctive clinical picture. SCA6 is a late-onset cerebellar syndrome, with relatively minimal brain stem and cerebral cortex symptoms...
September 2008: Brain: a Journal of Neurology
Anne-Fleur van Rootselaar, Natasha M Maurits, Remco Renken, Johannes H T M Koelman, Johannes M Hoogduin, Klaus L Leenders, Marina A J Tijssen
OBJECTIVE: To apply and validate the use of electromyogram (EMG) recorded during functional magnetic resonance imaging (fMRI) in patients with movement disorders, to directly relate involuntary movements to brain activity. METHODS: Eight "familial cortical myoclonic tremor with epilepsy" (FCMTE) patients, with tremor-like cortical myoclonus and cerebellar Purkinje cell degeneration, and nine healthy controls performed hand posture and movement in an on/off fashion (block design)...
December 2008: Human Brain Mapping
Anne-Fleur van Rootselaar, Sandra M A van der Salm, Lo J Bour, Mark J Edwards, Peter Brown, Eleonora Aronica, Johanna M Rozemuller-Kwakkel, Peter J Koehler, Johannes H T M Koelman, John C Rothwell, Marina A J Tijssen
Cortical hyperexcitability is a feature of "familial cortical myoclonic tremor with epilepsy" (FCMTE). However, neuropathological investigations in a single FCMTE patient showed isolated cerebellar pathology. Pathological investigations in a second FCMTE patient, reported here, confirmed cerebellar Purkinje cell degeneration and a normal sensorimotor cortex. Subsequently, we sought to explore the nature of cerebellar and motor system pathophysiology in FCMTE. Eye movement recordings and transcranial magnetic stimulation performed in six related FCMTE patients showed impaired saccades and smooth pursuit and downbeat nystagmus upon hyperventilation, as in patients with spinocerebellar ataxia type 6...
December 2007: Movement Disorders: Official Journal of the Movement Disorder Society
W Regragui, A Gerdelat-Mas, M Simonetta-Moreau
For 15 years, 50 Japanese and European families with cortical myoclonic tremor and epilepsy were reported in the literature under various names. More recently, the acronym familial cortical myoclonic tremor with epilepsy (FCMTE) has been proposed for this new clinical entity based on both clinical and electrophysiological criteria: irregular postural myoclonic tremor of the distal limbs, familial history of epilepsy, autosomal dominant inheritance, and a rather benign outcome. The diagnosis is confirmed by electrophysiological features favoring cortical reflex myoclonus (enhanced C reflex at rest, giant somatosensory evoked potentials (SEPs), premyoclonus cortical spikes detected by the jerk-locked back-averaging method), and a good response to antiepileptic drugs...
September 2006: Neurophysiologie Clinique, Clinical Neurophysiology
Anne-Fleur van Rootselaar, Natasha M Maurits, Johannes H T M Koelman, Johannes H van der Hoeven, Lo J Bour, Klaus L Leenders, Peter Brown, Marina A J Tijssen
Familial cortical myoclonic tremor with epilepsy (FCMTE) is characterized by a distal kinetic tremor, infrequent epileptic attacks, and autosomal dominant inheritance. The tremor is thought to originate from the motor cortex. In our patient group, a premovement cortical spike could not be established on electroencephalogram (EEG) back-averaging. Corticomuscular and intermuscular coherence analysis can demonstrate a cortical common drive to muscles. We carried out coherence analysis of electromyography (EMG) of forearm muscles and EEG of contralateral motor cortex in 7 FCMTE patients, 8 essential tremor (ET) patients, and 7 healthy controls...
February 2006: Movement Disorders: Official Journal of the Movement Disorder Society
Anne-Fleur van Rootselaar, Ivo N van Schaik, Arn M J M van den Maagdenberg, Johannes H T M Koelman, Petra M C Callenbach, Marina A J Tijssen
Fifty Japanese and European families with cortical myoclonic tremor and epilepsy have been reported under various names. Unfamiliarity with the syndrome often leads to an initial misdiagnosis of essential tremor or progressive myoclonus epilepsy. A detailed overview of the literature is lacking and is the scope of this study. Disease characteristics are adult onset, distal action tremor and myoclonus, epileptic seizures, autosomal dominant inheritance, benign course, effectiveness of antiepileptic drugs, and possibly cognitive decline...
June 2005: Movement Disorders: Official Journal of the Movement Disorder Society
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