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https://www.readbyqxmd.com/read/29040419/high-rates-of-human-fecal-carriage-of-mcr-1-positive-multi-drug-resistant-enterobacteriaceae-isolates-emerge-in-china-in-association-with-successful-plasmid-families
#1
Lan-Lan Zhong, Hang T T Phan, Cong Shen, Karina Doris-Vihta, Anna E Sheppard, Xi Huang, Kun-Jiao Zeng, Hong-Yu Li, Xue-Fei Zhang, Sandip Patil, Derrick W Crook, A Sarah Walker, Yong Xing, Jia-Lin Lin, Lian-Qiang Feng, Yohei Doi, Yong Xia, Nicole Stoesser, Guo-Bao Tian
Objectives: mcr-1-mediated colistin resistance in Enterobacteriaceae is concerning, as colistin is used in treating multidrug-resistant Enterobacteriaceae infections. Rates of human mcr-1 gastrointestinal carriage have historically been low. We identified trends in human fecal mcr-1-positivity rates and colonization with mcr-1-positive+third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae in Guangzhou, China, and investigated the genetic contexts of mcr-1 in a subset of mcr-1-positive+3GC-R strains...
October 10, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29038441/distinct-mechanisms-of-acquisition-of-mcr-1-bearing-plasmid-by-salmonella-strains-recovered-from-animals-and-food-samples
#2
Mingquan Cui, Jinfei Zhang, Chunping Zhang, Ruichao Li, Edward Wai-Chi Chan, Chenbin Wu, Congming Wu, Sheng Chen
Since the report of its discovery in E. coli in late 2015, the plasmid-mediated colistin resistance gene, mcr-1, has been detected in various bacterial species in clinical setting and various environmental niches. However, the transmission mechanisms of this gene in Salmonella is less defined. In this study, we conducted a comprehensive study to characterize the genetic features of mcr-1-positive Salmonella strains isolated from animals and foods. Our data revealed that Salmonella recovered from animals and food specimens exhibited highly different PFGE patterns, and acquired mcr-1-encoding plasmids via different mechanism...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28830739/molecular-bases-for-multidrug-resistance-in-yersinia-pseudotuberculosis
#3
Nicolas Cabanel, Marc Galimand, Christiane Bouchier, Margarita Chesnokova, Valery Klimov, Elisabeth Carniel
The enteropathogen Yersinia pseudotuberculosis causes gastrointestinal infections in humans. Although this species is usually susceptible to antibiotics active against Gram-negative bacteria, we identified three multidrug resistant (MDR) strains of Y. pseudotuberculosis that were isolated from the environment in Russia and from a patient in France. The resistance traits of the two Russian isolates were transferable at high frequencies (≈2×10(-1)/donor CFU) to Y. pseudotuberculosis. In contrast no transfer of the antibiotic resistances carried by the French strain was observed...
August 16, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28818900/genome-sequence-of-an-australian-monophasic-salmonella-enterica-subsp-enterica-typhimurium-isolate-tw-stm6-carrying-a-large-plasmid-with-multiple-antimicrobial-resistance-genes
#4
Mike L Dyall-Smith, Yuhong Liu, Helen Billman-Jacobe
We report the genome sequence of a monophasic Salmonella enterica subsp. enterica Typhimurium strain (TW-Stm6) isolated in Australia that is similar to epidemic multidrug-resistant strains from Europe and elsewhere. This strain carries additional antibiotic and heavy-metal resistance genes on a large (275-kb) IncHI2 plasmid.
August 17, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28797324/novel-mcr-3-variant-encoding-mobile-colistin-resistance-in-an-st131-escherichia-coli-isolate-from-bloodstream-infection-denmark-2014
#5
Louise Roer, Frank Hansen, Marc Stegger, Ute Wolff Sönksen, Henrik Hasman, Anette M Hammerum
A novel variant of the plasmid-borne colistin resistance gene mcr-3 was detected on an IncHI2 plasmid in an ST131 CTX-M-55-producing Escherichia coli isolate from a Danish patient with bloodstream infection in 2014. The discovery of novel plasmid-borne genes conferring resistance to colistin is of special interest since colistin has reemerged as an important drug in the treatment of infections with multidrug-resistant Gram-negative bacteria.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28771073/co-occurrence-of-3-different-resistance-plasmids-in-a-multi-drug-resistant-cronobacter-sakazakii-isolate-causing-neonatal-infections
#6
Lining Shi, Quanhui Liang, Zhe Zhan, Jiao Feng, Yachao Zhao, Yong Chen, Mei Huang, Yigang Tong, Weili Wu, Weijun Chen, Xiaojun Li, Zhe Yin, Jinglin Wang, Dongsheng Zhou
Cronobacter sakazakii 505108 was isolated from a sputum specimen of a neonate with severe pneumonia. C. sakazakii 505108 co-harbors 3 resistance plasmids of the IncHI2, IncX3, and IncFIB incomparability groups, respectively. These 3 plasmids have acquired several accessory modules, which carry an extremely large number of resistance genes, especially including those involved in resistance to carbapenems, aminoglycoside, tetracyclines, and phenicols and sulphonamide/trimethoprim. These plasmid-borne antibiotic resistance genes were associated with insertion sequences, integrons, and transposons, indicating that the assembly and mobilization of the corresponding accessory modules with complex chimera structures are facilitated by transposition and/or homologous recombination...
August 3, 2017: Virulence
https://www.readbyqxmd.com/read/28757017/characterization-of-ndm-5-positive-extensively-resistant-escherichia-coli-isolates-from-dairy-cows
#7
Tao He, Ruicheng Wei, Lili Zhang, Lichang Sun, Maoda Pang, Ran Wang, Yang Wang
The aim of this study was to investigate the prevalence of blaNDM-5 gene in Escherichia coli isolates from dairy cows and to characterize the molecular traits of the blaNDM-5-positive isolates. A total of 169 cows were sampled (169 feces and 169 raw milk samples) in three dairy farms in Jiangsu Province and 203 E. coli isolates were recovered. Among these strains, three isolates carried blaNDM-5 gene, including one co-harboring mcr-1, which belonged to sequence type 446 and the other two belonged to ST2. Susceptibility testing revealed that the three blaNDM-5-positive isolates showed extensive resistance to antimicrobials...
August 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28739785/emergence-of-mcr-1-in-raoultella-ornithinolytica-and-escherichia-coli-isolates-from-retail-vegetables-in-china
#8
Juan Luo, Xu Yao, Luchao Lv, Yohei Doi, Xiuyu Huang, Sicheng Huang, Jian-Hua Liu
The presence of mcr-1 among Enterobacteriaceae isolates collected from retail vegetables in China between 2015 and 2016 was investigated. Two Raoultella ornithinolytica and seven Escherichia coli strains recovered from lettuce and tomato samples were identified as MCR-1-producers. Similar to isolates from animals and humans, the mcr-1 gene was located on the IncHI2/ST3, IncI2, or IncX4 plasmids. The presence of MCR-1-producing organisms in ready-to-eat food samples represents a serious risk for human health...
October 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28655818/novel-plasmid-mediated-colistin-resistance-gene-mcr-3-in-escherichia-coli
#9
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, Timothy R Walsh, Jianzhong Shen, Yang Wang
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the GenBank database. Here, we characterized a third mobile colistin resistance gene, mcr-3 The gene coexisted with 18 additional resistance determinants in the 261-kb IncHI2-type plasmid pWJ1 from porcine Escherichia colimcr-3 showed 45...
June 27, 2017: MBio
https://www.readbyqxmd.com/read/28643490/characterization-of-extended-spectrum-%C3%AE-lactamase-genes-of-shigella-flexneri-isolates-with-fosfomycin-resistance-from-patients-in-china
#10
Yanyan Liu, Yue Cheng, Haifei Yang, Lifen Hu, Jun Cheng, Ying Ye, Jiabin Li
BACKGROUND: The emergence of fosfomycin resistance and extended-spectrum β-lactamase (ESBL) genes is a serious threat to public health and a new challenge in shigellosis treatment. The purpose of this study was to identify fosfomycin resistance and characterize β-lactamase genes in fos-carrying isolates of Shigella flexneri from patients in China. METHODS: A total of 263 S. flexneri isolates were collected from 34 hospitals in the Anhui Province of China during September 2012-September 2015 and screened for fosA3, fosA, and fosC2 by PCR amplification and sequencing...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28642846/decreased-fitness-and-virulence-in-st10-escherichia-coli-harboring-blandm-5-and-mcr-1-against-a-st4981-strain-with-blandm-5
#11
Yawei Zhang, Kang Liao, Hua Gao, Qi Wang, Xiaojuan Wang, Henan Li, Ruobing Wang, Hui Wang
Although coexistence of blaNDM-5 and mcr-1 in Escherichia coli has been reported, little is known about the fitness and virulence of such strains. Three carbapenem-resistant Escherichia coli (GZ1, GZ2, and GZ3) successively isolated from one patient in 2015 were investigated for microbiological fitness and virulence. GZ1 and GZ2 were also resistant to colistin. To verify the association between plasmids and fitness, growth kinetics of the transconjugants were performed. We also analyzed genomic sequences of GZ2 and GZ3 using PacBio sequencing...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28390961/sequencing-and-comparative-genomics-analysis-of-the-inchi2-plasmids-pt5282-mpha-and-p112298-cata-and-the-inchi5-plasmid-pynkp001-dfra
#12
Quanhui Liang, Zhe Yin, Yachao Zhao, Liqi Liang, Jiao Feng, Zhe Zhan, Hui Wang, Yajun Song, Yigang Tong, Weili Wu, Weijun Chen, Jinglin Wang, Lingxiao Jiang, Dongsheng Zhou
Incompatibility group IncHI plasmids are important vectors of antibiotic resistance in Enterobacteriaceae. In this study, a scheme for typing IncHI into five separately clustering subgroups, including previously designated IncHI1-3 as well as IncHI4-5, was proposed based on sequenced IncHI plasmids. The complete nucleotide sequences of the IncHI2 plasmids pT5282-mphA and p112298-catA and the IncHI5 plasmid pYNKP001-dfrA from clinical Enterobacter cloacae, Citrobacter freundii and Raoultella ornithinolytica isolates, respectively, were determined and were compared with IncHI2 and IncHI5 reference plasmids...
June 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28379732/prevalence-of-plasmid-mediated-fosfomycin-resistance-gene-fosa3-among-ctx-m-producing-escherichia-coli-isolates-from-chickens-in-china
#13
Wei Jiang, Shuai Men, Linghan Kong, Suzhen Ma, Yongqiang Yang, Yongxiang Wang, Qiwu Yuan, Guangyang Cheng, Wencheng Zou, Hongning Wang
The aim of this study was to investigate the prevalence of fosfomycin resistance gene fosA3 and characterize plasmids harboring fosA3 among CTX-M-producing Escherichia coli from chickens in China. A total of 234 CTX-M-producing E. coli isolates collected from chickens from 2014 to 2016 were screened for the presence of plasmid-mediated fosfomycin resistance genes (fosA, fosA3, and fosC2). Clonal relatedness of fosA3-positive isolates was determined by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST)...
April 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28348875/short-term-evolution-of-shiga-toxin-producing-escherichia-coli-o157-h7-between-two-food-borne-outbreaks
#14
Lauren A Cowley, Timothy J Dallman, Stephen Fitzgerald, Neil Irvine, Paul J Rooney, Sean P McAteer, Martin Day, Neil T Perry, James L Bono, Claire Jenkins, David L Gally
Shiga toxin-producing Escherichia coli (STEC) O157:H7 is a public health threat and outbreaks occur worldwide. Here, we investigate genomic differences between related STEC O157:H7 that caused two outbreaks, eight weeks apart, at the same restaurant. Short-read genome sequencing divided the outbreak strains into two sub-clusters separated by only three single-nucleotide polymorphisms in the core genome while traditional typing identified them as separate phage types, PT8 and PT54. Isolates did not cluster with local strains but with those associated with foreign travel to the Middle East/North Africa...
September 2016: Microbial Genomics
https://www.readbyqxmd.com/read/28293682/genome-sequence-of-the-thermotolerant-foodborne-pathogen-salmonella-enterica-serovar-senftenberg-atcc-43845-and-phylogenetic-analysis-of-loci-encoding-increased-protein-quality-control-mechanisms
#15
Scott V Nguyen, Gregory P Harhay, James L Bono, Timothy P L Smith, Dayna M Harhay
Salmonella enterica subsp. enterica bacteria are important foodborne pathogens with major economic impact. Some isolates exhibit increased heat tolerance, a concern for food safety. Analysis of a finished-quality genome sequence of an isolate commonly used in heat resistance studies, S. enterica subsp. enterica serovar Senftenberg 775W (ATCC 43845), demonstrated an interesting observation that this strain contains not just one, but two horizontally acquired thermotolerance locus homologs. These two loci reside on a large 341...
January 2017: MSystems
https://www.readbyqxmd.com/read/28261566/efflux-pump-overexpression-contributes-to-tigecycline-heteroresistance-in-salmonella-enterica-serovar-typhimurium
#16
Yi Chen, Daxing Hu, Qijing Zhang, Xiao-Ping Liao, Ya-Hong Liu, Jian Sun
Bacterial heteroresistance has been identified in several combinations of bacteria and antibiotics, and it complicated the therapeutic strategies. Tigecycline is being used as one of the optimal options for the treatment of infections caused by multidrug-resistant Salmonella. This study investigated whether heterorresistance to tigecycline exists in a Salmonella enterica serovar Typhimurium strain harboring the oqxAB-bearing IncHI2 plasmid pHXY0908. MIC and population analyses were performed to evaluate population-wide susceptibility to tigecycline...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28242598/research-progress-on-the-plasmid-mediated-colistin-resistance-gene-mcr-1
#17
REVIEW
Ling-xian Yi, Yi-yun Liu, Ren-jie Wu, Zi-sen Liang, Jian-Hua Liu
mcr-1, the first plasmid-mediated colistin-resistance gene, can mediate polymyxin resistance and be transferred horizontally via plasmids. Many studies have confirmed its distribution via epidemic plasmids (IncI2, IncX4, IncHI2, etc.), as well as mobile genetic elements, among Enterobacteriaceae isolated from animals, humans, and the environment in 35 countries. These studies provide the basis of understanding the complicated mechanism of colistin resistance mediated by MCR-1 and its global dissemination and epidemic properties, and also enrich antimicrobial resistance mechanisms...
February 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28238801/chromosomal-location-of-the-fosa3-and-blactx-m-genes-in-proteus-mirabilis-and-clonal-spread-of-escherichia-coli-st117-carrying-fosa3-positive-inchi2-st3-or-f2-a-b-plasmids-in-a-chicken-farm
#18
Dandan He, Lanping Liu, Baowei Guo, Shengjun Wu, Xiaojie Chen, Jing Wang, Zhenling Zeng, Jian-Hua Liu
The aim of this study was to investigate the spread and location of the fosA3 gene among Enterobacteriaceae from diseased broiler chickens. Twenty-nine Escherichia coli and seven Proteus mirabilis isolates recovered from one chicken farm were screened for the presence of plasmid-mediated fosfomycin resistance genes by PCR. The clonal relatedness of fosA3-positive isolates, the transferability and location of fosA3, and the genetic context of the fosA3 gene were determined. Seven P. mirabilis isolates with three different pulsed-field gel electrophoresis (PFGE) patterns and five E...
April 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28193662/prevalence-and-molecular-characterization-of-mcr-1-positive-salmonella-strains-recovered-from-clinical-specimens-in-china
#19
Mingquan Cui, Jinfei Zhang, Zhen Gu, Ruichao Li, Edward Wai-Chi Chan, Meiyin Yan, Congming Wu, Xuebin Xu, Sheng Chen
The recently discovered colistin resistance element, mcr-1, adds to the list of antimicrobial resistance genes that rapidly erode the antimicrobial efficacy of not only the commonly used antibiotics but also the last-line agents of carbapenems and colistin. This study investigated the prevalence of the mobile colistin resistance determinant mcr-1 in Salmonella strains recovered from clinical settings in China and the transmission potential of mcr-1-bearing mobile elements harbored by such isolates. The mcr-1 gene was recoverable in 1...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28125687/high-heterogeneity-of-escherichia-coli-sequence-types-harbouring-esbl-ampc-genes-on-inci1-plasmids-in-the-colombian-poultry-chain
#20
Luis Ricardo Castellanos, Pilar Donado-Godoy, Maribel León, Viviana Clavijo, Alejandra Arevalo, Johan F Bernal, Arjen J Timmerman, Dik J Mevius, Jaap A Wagenaar, Joost Hordijk
BACKGROUND: Escherichia coli producing ESBL/AmpC enzymes are unwanted in animal production chains as they may pose a risk to human and animal health. Molecular characterization of plasmids and strains carrying genes that encode these enzymes is essential to understand their local and global spread. OBJECTIVES: To investigate the diversity of genes, plasmids and strains in ESBL/AmpC-producing E. coli from the Colombian poultry chain isolated within the Colombian Integrated Program for Antimicrobial Resistance Surveillance (Coipars)...
2017: PloS One
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