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Lingual nerve

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https://www.readbyqxmd.com/read/29133390/recovery-of-taste-organs-and-sensory-function-after-severe-loss-from-hedgehog-smoothened-inhibition-with-cancer-drug-sonidegib
#1
Archana Kumari, Alexandre N Ermilov, Marina Grachtchouk, Andrzej A Dlugosz, Benjamin L Allen, Robert M Bradley, Charlotte M Mistretta
Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector Smoothened (SMO). We tested the potential for molecular, cellular, and functional recovery in mice from the severe disruption of taste-organ biology and taste sensation that follows HH/SMO signaling inhibition. Sonidegib treatment led to rapid loss of taste buds (TB) in both fungiform and circumvallate papillae, including disruption of TB progenitor-cell proliferation and differentiation...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29089549/mesiolingual-root-rotation-for-horizontal-mandibular-third-molar-extraction-position-classification-and-surgical-simulation
#2
Zhou-Xi Ye, Chi Yang
Extracting horizontal mandibular 3rd molars face considerable difficulty due to the large bone and adjacent tooth resistances. This study aims at evaluating the effectiveness of a novel method-mesiolingual root rotation to extract wisdom teeth of this type. In this study, 73 horizontal teeth extracted using piezosurgery were reviewed and classified based on impaction depth: position I, II, III refers to the highest portion of the crown on a level with upper 1/3, middle 1/3, lower 1/3 of the 2rd molar's root...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29079941/anatomic-study-of-the-position-of-the-mandibular-canal-and-corresponding-mandibular-third-molar-on-cone-beam-computed-tomography-images
#3
Liqun Gu, Chao Zhu, Kejia Chen, Xianchu Liu, Zhangui Tang
PURPOSE: The positional relationship between the mandibular canal and corresponding third molars is a key anatomic factor of inferior alveolar nerve (IAN) injury. The aim of the present study is to classify the anatomic three-dimensional relationship between the mandibular third molar and the mandibular canal on cone-beam computed tomography (CBCT) images. METHODS: This study used CBCT images to classify the positional relationship between the mandibular canal and corresponding third molars...
October 27, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29074859/the-characteristics-of-adjacent-anatomy-of-mandibular-third-molar-germs-a-cbct-study-to-assess-the-risk-of-extraction
#4
Rui Sun, Yu Cai, Yi Yuan, Ji-Hong Zhao
This study aims to investigate the characteristics of adjacent anatomy of mandibular third molar germs (MTMGs). Three hundred Chinese patients aged 12 to 17 years old who received cone-beam computed tomography (CBCT) were enrolled. The continuity of cortical outline of inferior alveolar canals (IACs) in the region of MTMGs, the integrity of lingual bone cortex and the relationship between hard tissue part of MTMGs and IACs were investigated by observing CBCT data via the NNT viewer software. The age, degree of dental development, gender and location were recorded as variables...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29061470/injury-to-the-inferior-alveolar-and-lingual-nerves-in-successful-and-failed-coronectomies-systematic-review
#5
REVIEW
M Dalle Carbonare, A Zavattini, M Duncan, M Williams, A Moody
The aim of this systematic review was to evaluate the incidence of damage to the inferior alveolar (IAN) and dental nerves in successful coronectomies, and to compare the results with coronectomies that failed. To the best of our knowledge no such analyses have been reported. Between January 1990 and October 2016 we surveyed published papers to find those that examined clinical outcomes after coronectomy. Fourteen met the criteria for final inclusion. Of 2087 coronectomies, 152 failed (7%). Successful procedures were associated with a low overall incidence of injury to the IAN (0...
October 20, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29038638/a-self-retaining-lingual-flap-guarding-device-during-surgical-removal-of-impacted-mandibular-third-molar
#6
Yuvaraj Vaithilingam, T S Balaji, Nithin Jude Joseph, Varsha Murthy, Suresh Kumar
INTRODUCTION: Lingual nerve damage is one of the common complications following mandibular third molar surgery. On considering the impact of lingual nerve damage on the patient's quality of life, it is necessary to exercise caution to minimize its occurrence. MATERIAL AND METHODS: Although many lingual retractors are available, in this article we describe an indigenously designed lingual retractor for use in mandibular third molar surgery. CONCLUSION: The indigenous lingual retractor described in this article provides advantages like clear access and excellent retention unlike conventional retractors...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29035699/risk-factors-for-complications-of-intraoral-removal-of-submandibular-sialoliths
#7
Sung Hwa Dong, Seok Hyun Kim, Jeon Gang Doo, Ah Ra Jung, Young Chan Lee, Young-Gyu Eun
PURPOSE: Intraoral removal of submandibular sialoliths is a surgical technique for the treatment of sialolithiasis and is reported to have excellent outcomes. The aim of this study was to determine the risk factors leading to complications of this procedure. PATIENTS AND METHODS: The medical records of 200 patients who had undergone intraoral removal of sialoliths from January 2006 through June 2015 were retrospectively reviewed. A telephone survey was used to check postoperative symptoms...
September 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29023985/interaction-between-calcitonin-gene-related-peptide-immunoreactive-neurons-and-satellite-cells-via-p2y12-r-in-the-trigeminal-ganglion-is-involved-in-neuropathic-tongue-pain-in-rats
#8
Shiori Sugawara, Shinji Okada, Ayano Katagiri, Hiroto Saito, Tatsuro Suzuki, Hiroki Komiya, Kohei Kanno, Kinuyo Ohara, Toshimitsu Iinuma, Akira Toyofuku, Koichi Iwata
The P2Y12 receptor expressed in satellite cells of the trigeminal ganglion is thought to contribute to neuropathic pain. The functional interaction between neurons and satellite cells via P2Y12 receptors and phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) underlying neuropathic pain in the tongue was evaluated in this study. Expression of P2Y12 receptor was enhanced in pERK1/2-immunoreactive cells encircling trigeminal ganglion neurons after lingual nerve crush. The administration to lingual nerve crush rats of a selective P2Y12 receptor antagonist, MRS2395, attenuated tongue hypersensitivity to mechanical and heat stimulation and suppressed the increase in the relative numbers of calcitonin gene-related peptide (CGRP)-immunoreactive neurons and neurons encircled by pERK1/2-immunoreactive cells...
October 11, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28993238/thalamo-insular-pathway-conveying-orofacial-muscle-proprioception-in-the-rat
#9
Fumihiko Sato, Yume Uemura, Chiharu Kanno, Yumi Tsutsumi, Akiko Tomita, Ayaka Oka, Takafumi Kato, Katsuro Uchino, Jumpei Murakami, Tahsinul Haque, Yoshihisa Tachibana, Atsushi Yoshida
Little is known about how proprioceptive signals arising from muscles reach to higher brain regions such as the cerebral cortex. We have recently shown that a particular thalamic region, the caudo-ventromedial edge (VPMcvm) of ventral posteromedial thalamic nucleus (VPM), receives the proprioceptive signals from jaw-closing muscle spindles (JCMSs) in rats. In this study, we further addressed how the orofacial thalamic inputs from the JCMSs were transmitted from the thalamus (VPMcvm) to the cerebral cortex in rats...
December 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28981824/thirst-increases-chorda-tympani-responses-to-sodium-chloride
#10
Thomas G Mast, Joseph M Breza, Robert J Contreras
In nature, water is present as a low-salt solution, thus we hypothesized that thirst would increase taste responses to low-salt solutions. We investigated the effect of thirst on the 2 different salt detection mechanisms present in the rat chorda tympani (CT) nerve. The first mechanism is dependent upon the epithelial sodium channel (ENaC), is blocked by benzamil, and is specific to the cation sodium. The second mechanism, while undefined, is independent of ENaC, and detects multiple cations. We expected thirst to increase benzamil-sensitive sodium responses due to mechanistically increasing the benzamil-sensitive ENaC...
October 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28947684/-oral-anatomy
#11
Shinichi Abe
With regard to oral cavity, it is known that jaw bone morphology greatly changes with tooth loss. Therefore, it is necessary to consider the muscles attached to the jaw bone and the surrounding vessels and nerves, in connection with the jaw bone morphology after tooth loss. As an example, the height of the mandibular bone decreases to the position of the mylohyoid line after tooth loss. By this marked morphological change in the alveolar area, the lingual nerve and the lingual artery branches running in the sublingual area on the mandibular inner surface becomes located in the area almost the same as the alveolar crest...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28872502/lingual-short-split-a-bilateral-sagittal-split-osteotomy-technique-modification
#12
Eduardo Sant'Ana, Denis Pimenta E Souza, Astrid Buysse Temprano, Elio H Shinohara, Paulo Esteves Pinto Faria
The technique of sagittal split osteotomy of the mandibular ramus is an established technique that has been evolving over the years, with significant improvements regarding stability, better bone contact between the segments, and possibilities of osteosynthesis. However, paresthesia is common in the postoperatory, sometimes permanent, and undesirable fractures in the subcondylar region can occur leading to longer operative time and extraoral scars. The short lingual split technique is an easy technique that simplifies the horizontal osteotomy of the ramus and decreases the risk of undesirable fractures with a neurosensitive recovery of patients in a much shorter time because of minor trauma and nerve manipulation during the execution...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28834578/phenotypic-change-in-trigeminal-ganglion-neurons-associated-with-satellite-cell-activation-via-extracellular-signal-regulated-kinase-phosphorylation-is-involved-in-lingual-neuropathic-pain
#13
Lou Mikuzuki, Hiroto Saito, Ayano Katagiri, Shinji Okada, Shiori Sugawara, Asako Kubo, Kinuyo Ohara, Jun Lee, Akira Toyofuku, Koichi Iwata
Iatrogenic trigeminal nerve injuries remain a common and complex clinical problem. Satellite glial cell (SGC) activation, associated phosphorylation of extracellular signal-regulated kinase (ERK), and neuropeptide expression in the trigeminal ganglion (TG) are known to be involved in trigeminal neuropathic pain related to trigeminal nerve injury. However, the involvement of these molecules in orofacial neuropathic pain mechanisms is still unknown. Phosphorylation of ERK1/2 in lingual nerve crush (LNC) rats was observed in SGCs...
August 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28811811/transient-hypoglossal-nerve-palsy-after-transoral-intubation-for-general-anesthesia
#14
Young Jin Choi, Jin Hee Lee, Young Duck Shin
Hypoglossal nerve palsy induces palsy in the ipsilateral lingual muscles, resulting in tongue deviation and articulation disorder. It is a rare condition that may stem from a variety of causes. Therefore, it is important to consider the possible causes of hypoglossal nerve palsy related to surgery or anesthesia, including intubation, the surgical positions, and mask ventilation during recovery.
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28763879/-study-of-fraction-amplitude-of-low-frequency-fluctuation-on-resting-state-functional-magnetic-resonance-imaging-in-adultperipheral-facial-paralysis
#15
Y J Zhu, G L Ma, T B Song, L Du, R C Guo, S L Sun, H Li, L G Sun
Objective: To analysis the change of brain functional activity in the left and right peripheral facial paralysis by using resting-state functional magnetic resonance imaging (R-fMRI) of fraction amplitude of low frequency fluctuation(fALFF) measurement technique, and research the abnormal brain region with different side patients whether there are differences. Methods: A total of 43 patients with peripheral facial paralysis patients (patient groups, divided into left / right two subgroups) and 21 healthy volunteers (control group) in this study...
July 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28724864/anatomic-and-histological-study-of-lingual-nerve-and-its-clinical-implications
#16
Yoshiaki Shimoo, Masahito Yamamoto, Masashi Suzuki, Masato Yamauchi, Akihiro Kaketa, Masaaki Kasahara, Masamitsu Serikawa, Kei Kitamura, Satoru Matsunaga, Shinichi Abe
Although the risk of injuring the lingual nerve in the mandibular molar area during dental treatment is high, it can be repaired by nerve grafting. However, from the perspective of clinical dentistry, the pathway and histomorphometric characteristics of this nerve remain to be documented in detail. The purpose of the present study was to morphologically elucidate the pathway of the lingual nerve to clarify its significance in a clinical setting. A histomorphometric analysis was also performed in consideration of nerve grafting...
2017: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/28717288/cone-beam-computed-tomographic-analysis-of-the-course-and-position-of-mandibular-canal
#17
Hooman Khorshidi, Saeed Raoofi, Janan Ghapanchi, Shoaleh Shahidi, Maryam Paknahad
PURPOSE: Estimation of the relative position of infra alveolar nerve (IAN) canal and its relation to the mandibular anatomical landmarks can be clinically useful in minimizing the risk of surgery complications such as neurosensory disturbances that may occur after invasive mandibular surgical procedures. The purpose of the present study was to investigate the anatomic location and radiographic course of the mandibular canal compared to anatomic landmarks on CBCT and to discuss its clinical significance and also to determine the possible correlations between the mandibular position and the age of the patients...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28716800/relationship-between-vascular-resistance-and-sympathetic-nerve-fiber-density-in-arterial-vessels-in-children-with-sleep-disordered-breathing
#18
Anna Kontos, Kurt Lushington, James Martin, Quenten Schwarz, Ryan Green, David Wabnitz, Xiangjun Xu, Elke M Sokoya, Scott Willoughby, Mathias Baumert, Antonio Ferrante, Melissa La Forgia, Declan Kennedy
BACKGROUND: Sleep disordered breathing in children is associated with increased blood flow velocity and sympathetic overactivity. Sympathetic overactivity results in peripheral vasoconstriction and reduced systemic vascular compliance, which increases blood flow velocity during systole. Augmented blood flow velocity is recognized to promote vascular remodeling. Importantly, increased vascular sympathetic nerve fiber density and innervation in early life plays a key role in the development of early-onset hypertension in animal models...
July 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28669486/method-of-osteotomy-fixation-and-need-for-removal-following-bimaxillary-orthognathic-osseous-genioplasty-and-intranasal-surgery-a-retrospective-cohort-study
#19
J C Posnick, E Choi, A Chavda
The purpose of this study was to determine the incidence and causes of fixation hardware removal after bimaxillary orthognathic, osseous genioplasty, and intranasal surgery. A retrospective study was performed, involving subjects with a bimaxillary developmental dentofacial deformity (DFD) and symptomatic chronic obstructive nasal breathing. At a minimum, subjects underwent Le Fort I osteotomy, bilateral sagittal ramus osteotomies (SROs), septoplasty, inferior turbinate reduction, and osseous genioplasty. The primary outcome variable studied was fixation hardware removal...
October 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28637999/a-morphological-study-of-the-foramina-of-the-mandible-in-the-japanese-macaque-by-cone-beam-computed-tomography
#20
Masataka Sunohara, Yoko Miwa, Iwao Sato
The mandibular canal (MC) contains vessels and nerves in the mandible of the Japanese macaque (JM). The inferior alveolar nerves and vessels of the mandible insert from the mandibular foramen and then run through the MC, the mental foramen and spinal foramen to the outside of the mandible. However, the detailed morphological properties of multiple canals, such as the accessory canal (AC) of the mandible, are unknown in JMs. The purpose of this study was to describe the multiple canals of JMs and to determine the location and analyse the measurements of the JM mandible...
2017: Okajimas Folia Anatomica Japonica
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