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Myastenia gravis

V I Kravchenko, A A Chumak, K M Loganovsky, I S Diagil, V F Kuzmenko
A clinical case of the rituximab («Rituksim», «Mabthera») use to treat a man affected by the Chornobyl NPP acci dent with malignant resistant form of myasthenia gravis in conjunction with chronic mixed infection by Toxoplasma, Epstein Barr virus, Cytomegalovirus and Herpes simplex virus is described. In the dynamics of two year's observa tion the clinical efficacy of monoclonal antibodies was shown as the main symptoms stabilization and reducing doses of glucocorticoid and anticholinergic therapy. The positive effect was marked in the nearest and remote peri ods...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
Cuneyd Sevinc, Muhsin Balaban, Orkunt Ozkaptan, Ugur Yucetas, Tahir Karadeniz
OBJECTIVE: To evaluate the treatment modalities of total ureteral avulsion and to clarify the risk factors of this serious complication. METHODS: This study retrospectively analyzed the data of 3 patients with complete ureteral avulsion during ureteroscopy. Of the three patients, two had distal ureteral complete avulsion, and one total ureteral avulsion on both ends. Ureteroneocystostomy (UNC) was immediately performed after distal ureteral avulsion cases. Ileal ureter substition was performed on the same session after the total ureteral avulsion in both ends...
July 4, 2016: Archivio Italiano di Urologia, Andrologia
Funda Özel, Ali Aydın Altunkan, Mustafa Azizoğlu
Myasthenia gravis (MG) is an autoimmune disease caused by the development of antibodies against the nicotinic acetylcholine receptor. There is hypersensitivity against non-depolarizing muscle relaxants in these patients. Sugammadex eliminates the effects of steroid non-depolarizing muscle relaxants, such as rocuronium and vecuronium, by selectively encapsulating their molecules. In this case report, we present a case of recurarization and respiratory failure after the use of sugammadex and rocuronium in a patient with preoperatively undiagnosed myasthenia gravis...
April 2016: Turkish Journal of Anaesthesiology and Reanimation
Burak Derkus, Yavuz Emre Arslan, Kaan C Emregul, Emel Emregul
In the present study, we describe the sonochemical isolation of nano-sized spherical hydroxyapatite (nHA) from egg shell and application towards thrombin aptasensing. In addition to the sonochemical method, two conventional methods present in literature were carried out to perform a comparative study. Various analysis methods including Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Energy-Dispersive Analysis of X-Rays (EDAX), and Thermal Gravimetric Analysis (TGA) have been applied for the characterization of nHA and its nanocomposite with marine-derived collagen isolated from Rhizostoma pulmo jellyfish...
September 1, 2016: Talanta
Clara Sangüesa Gómez, Bryan Josué Flores Robles, Clara Méndez Perles, Carmen Barbadillo, Hildegarda Godoy, José Luis Andréu
The association of dermatomyositis with myasthenia gravis (MG) is uncommon, having been reported so far in only 26 cases. We report the case of a 69 year-old man diagnosed with MG two years ago and currently treated with piridostigmyne. The patient developed acute proximal weakness, shoulder pain and elevated creatine-kinase (CK). He also developed generalized facial erythema and Gottron's papules. Laboratory tests showed positive antinuclear and anti-Mi2 antibodies. Further analysis confirmed CK levels above 1000 U/l...
July 2015: Reumatología Clinica
João Moreira-Pinto, Aníbal Ferreira, Alice Miranda, Carla Rolanda, Jorge Correia-Pinto
BACKGROUND: Video-assisted thoracoscopic surgery thymectomy has been used in the treatment of Myastenia Gravis and thymomas (coexisting or not). In natural orifice transluminal endoscopic surgery, new approaches to the thorax are emerging as alternatives to the classic transthoracic endoscopic surgery. The aim of this study was to assess the feasibility and reliability of hybrid endoscopic thymectomy (HET) using a combined transthoracic and transesophageal approach. METHODS: Twelve consecutive in vivo experiments were undertaken in the porcine model (4 acute and 8 survival)...
September 2014: Surgical Endoscopy
Hironori Ishibashi, Kenichi Okubo
The successful key of video-assisted thoracoscopic surgery (VATS) for mediastinal tumor should be appropriate surgical approach according to the site of tumor and relationship between large vessels and tumor. We retrospectively reviewed VATS for mediastinal tumor for 2 years. Thirty-three patients underwent surgery for mediastinal tumor, 19 patients by VATS;12 thymo-thymomectomies (2 myastenia gravis with thymoma), 4 neurinomas, 3 cystic tumors. Thymoma is the most frequent mediastinal tumor and thymo-thymomectomy for thymoma and extended thymectomy for myasthenia gravis is usually recommended...
October 2012: Kyobu Geka. the Japanese Journal of Thoracic Surgery
F Aysal, S Baybas, H H Selçuk, V Sozmen, M Ozturk, H Kucukoglu, N H Urer
No abstract text is available yet for this article.
May 2013: Clinical Neurology and Neurosurgery
Andreea-Madalina Stefanescu, E Ungureanu, Alina Tugui, Sanziana-Luminita Gradinaru
The authors present a case of ocular myastenia, suspected by an ophthalmologist and confirmed as diagnosis by a neurologist. There are discussion regarding the latest possibilities of treatment.
2011: Oftalmologia
Istrate Bogdan, Vîlciu Crisanda
Myasthenia Gravis is an organ-specific autoimmune disorder generaly thought to be caused by an antibody-mediated attack against the skeletal muscle nicotinic acetylcholine receptor (AChR) at the neuromuscular junction. Not infrequently there may be other diseases accompanying myasthenia, that can give different neuro-ophtalmological manifestations or neurological syndromes with autoimmune substrate. By these autoimmmune diseases we note:Autoimmune thyroiditis, Systemic lupus erythematous, Dermatomyositis, i...
2011: Oftalmologia
F Mignini, M Sabbatini, V D'Andrea, C Cavallotti
Human thymus of healthy subjects and patients affected by thymoma-associated Myastenia Gravis were studied in order to visualize and compare the morphological distributive pattern of four neuropeptides: vasoactive intestinal peptide, substance P, neuropeptide Y, and neurotensin. Based on our observations, we formulated hypotheses on their relations in neuro-immunomodulation under physiological and pathophysiological conditions. Immuno-histochemical staining for neuropeptides was performed and morphological and morphometrical analyses were conducted on healthy and diseased thymus...
May 2011: Peptides
Changyuan Sun, Fanping Meng, Yingxin Li, Quanxin Jin, Honghua Li, Fangfang Li
BACKGROUND: The binding of anti-acetylcholine receptor antibodies (AChRAb) to the main immunogenic region (MIR) of AChR alpha-subunit in the neuromuscular junction is the major pathogenesis of myasthenia gravis (MG). METHODS: A synthetic peptide of 10 amino acids corresponding to the MIR of human AChR was coupled with cellulose beads to make an antigen-specific immunoadsorbent (hMIR10-CB). RESULTS: The hMIR10-CB could remove AChRAb in MG sera by 40...
April 2010: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
J Tvrdon, J Schützner, J Pit'ha
The authors highlight disadvantages of the unilateral videothoracic approach in thymectomy procedures. They present a case-review of a young female patient, indicated for the procedure for myastenia gravis. In these patients, the primary objective is to remove all the thymus tissue and the surrounding adipose tissue within the anterior mediastinum, which, using the above approach cannot always be guaranteed. Considering the number of patients indicated for the procedure based on the above diagnosis, it is inevitable to perform the procedures in specialized centres, experienced with these conditions...
May 2009: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Lars Bergljung
Sir Geoffrey Keynes (1887 - 1982), was a pioneer in the surgery of breast cancer and thymic deseases, n.b. in patients suffering from myastenia gravis. He strongly disapproved of the longstanding dogma of so called radical mastectomy in breast cancer, and advocated a more limited surgical approach, followed by radiation therapy. This was done more than fifty years before breastconserving surgery has become the therapy of choice and against considerable opposition from the surgical establishment of his days...
2005: Svensk Medicinhistorisk Tidskrift
V N Zakutniaia, A S Ametov, B M Gekht, D V Sidnev, A G Sanadze, A N Ivanova
The article covers clinical and ophthalmologic characteristics of oculomotor disturbances in myastenic patients with endocrine ophtalmopathy, and differential diagnostic signs and peculiarities of endocrine ophtalmopathy in patients with a combination of the two diseases.
2006: Klinicheskaia Meditsina
Vincenzo Triggiani, Edoardo Guastamacchia, Ivan Lolli, Giuseppe Troccoli, Francesco Resta, Carlo Sabbà, Nadia Ruggieri, Emilio Tafaro
There are few cases described in the world literature reporting an association of thymoma (with myasthenia gravis or not) with hyperparathyroidism. In these cases the hyperparathyroidism was due to the presence of an adenoma or hyperplasic parathyroid tissue either in the cervical region or in an ectopic intrathymic location.(12345) In other cases the syndrome of hypercalcemia was due to the secretion of parathyroid-related protein (PTHRP) (6) or parathyroid hormone (PTH) (7) by the thymoma itself. We report the first case, at the best of our knowledge, of a wide invasive malignant thymoma (type B3), associated with myasthenia gravis and hyperparathyroidism caused by parathyroid adenoma...
2006: Immunopharmacology and Immunotoxicology
R Petkov, N Kŭtev, V Mladenovski, G Todorov, N Gavrilov, A Atanasov, N Goranov
OBJECTIVE: Thymectomy is considered an effective therapeutic option for patients with myasthenia gravis (MG). We reviewed our 25-years experience with surgical treatment of MG with respect to long-term results and factors affecting outcome. METHODS: Between 1978 and 2002, we performed 232 thymectomies for MG. Fifteen patients were lost to follow-up; the remaining 217 form the object of our study. 32 patients (28.4%) had thymoma. Myasthenia was graded according to a modified Osserman classification: 51 patients (23...
2004: Khirurgiia
Y Solak, O Dikbas, K Altundag, N Guler, Y Ozisik
Malignant thymomas are associated with numerous autoimmune disorders including myasthenia gravis. Myastenia gravis is characterized by antibodies against the acetylcholine receptors located on the neuromuscular junction of the skeletal muscle. We present a case with malignant thymoma who developed myasthenia crisis while he was treated with cisplatin chemotherapy.
June 2004: Journal of Experimental & Clinical Cancer Research: CR
Onder Arslan, Mutlu Arat, Ibrahim Tek, Erol Ayyildiz, Osman Ilhan
BACKGROUND: The number of therapeutic procedures is increasing steadily year by year with growing collaboration of departments other than Hematology. In the aim to demonstrate our single center activity we analyzed our data since four years. METHODS: Between years 1998 and 2001, 658 therapeutic plasma exchange (TPE) procedures were performed on 158 patients. Median age and male/female ratio were 37 (range, 15-87) and 80/78, respectively. Main indications were myastenia gravis (n=55, 34%), TTP (n=13, 8...
June 2004: Transfusion and Apheresis Science
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