keyword
MENU ▼
Read by QxMD icon Read
search

parotid cancer

keyword
https://www.readbyqxmd.com/read/28712533/dose-volume-toxicity-modeling-for-de-intensified-chemo-radiation-therapy-for-hpv-positive-oropharynx-cancer
#1
Panayiotis Mavroidis, Alex Price, David Fried, Mark Kostich, Robert Amdur, William Mendenhall, Chihray Liu, Shiva Das, Lawrence B Marks, Bhishamjit Chera
BACKGROUND AND PURPOSE: The aim is to determine the radiobiological parameters of four popular normal tissue complication probability (NTCP) models that describe the dose-response relations of salivary glands and pharyngeal constrictors to the severity of patient reported xerostomia and dysphagia, respectively 6 and 12months post chemo-radiotherapy, furthermore, to evaluate the goodness-of-fit of the NTCP models for different combinations of glands and constrictors. MATERIAL AND METHODS: Forty-three patients were treated on a prospective multi-institutional phase II study (ClinicalTrials...
July 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28709149/uptake-of-psma-ligands-in-normal-tissues-is-dependent-on-tumor-load-in-patients-with-prostate-cancer
#2
Florian C Gaertner, Khalil Halabi, Hojjat Ahmadzadehfar, Stefan Kürpig, Elisabeth Eppard, Charalambos Kotsikopoulos, Nikolaos Liakos, Ralph A Bundschuh, Holger Strunk, Markus Essler
Radioligand therapy (RLT) with Lu-177-labeled PSMA-ligands is a new therapy option for prostate cancer. Biodistribution in normal tissues is of interest for therapy planning. We evaluated if the biodistribution of Ga-68-PSMA-11 is influenced by tumor load. RESULTS: In patients with high tumor load, SUVmean was reduced to 61.5% in the lacrimal glands, to 56.6% in the parotid glands, to 63.7% in the submandibular glands, to 61.3% in the sublingual glands and to 55.4% in the kidneys (p < 0...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28693242/bufalin-sensitizes-human-bladder-carcinoma-cells-to-trail-mediated-apoptosis
#3
Kyung-Hwa Kang, Min Ho Han, Jin-Woo Jeong, Cheol Park, Sang-Hyup Lee, Hai Woong Lee, Sang Hoon Hong, Yung Hyun Choi, Su Hyun Hong
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily, has garnered interest as it is relatively non-toxic to normal cells, but selectively induces apoptotic cell death in multiple types of transformed or malignant cells. Bufalin is the major digoxin-like immunoreactive component of Sum Su, which is obtained from the skin and parotid venom gland of the toad. Bufalin is known to inhibit cell proliferation and induce apoptosis in a variety of cancer cells. The present study investigated whether bufalin promoted TRAIL-induced apoptotic cell death...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28688689/characterization-treatment-and-outcomes-of-salivary-ductal-carcinoma-using-the-national-cancer-database
#4
Virginia Osborn, Babak Givi, Anna Lee, Niki Sheth, Dylan Roden, David Schwartz, David Schreiber
OBJECTIVES: To analyze clinical, treatment and outcome data for patients with salivary ductal carcinoma in a large population-based sample. MATERIALS AND METHODS: The National Cancer Database was queried to identify patients diagnosed with salivary ductal carcinoma between 2004 and 2013. Kaplan Meier and Cox regression analysis were used to assess overall survival (OS) and identify impact of specific variables on OS. RESULTS: A total of 495 patients were identified...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28679448/simultaneous-integrated-boost-therapy-of-carcinoma-of-the-hypopharynx-larynx-with-and-without-flattening-filter-a-treatment-planning-and-dosimetry-study
#5
Barbara Dobler, Tina Obermeier, Matthias G Hautmann, Amine Khemissi, Oliver Koelbl
BACKGROUND: The aim of this study was to investigate if the flattening filter free (FFF) irradiation mode of a linear accelerator (linac) is advantageous as compared to the flat beam (FF) irradiation mode in intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) for carcinoma of the hypopharynx / larynx. METHODS: Four treatment plans were created for each of 10 patients for an Elekta Synergy linac with Agility collimating device, a dual arc VMAT and a nine field step and shoot IMRT each with and without flattening filter...
July 5, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28675085/impact-of-adjuvant-radiotherapy-for-malignant-salivary-gland-tumors
#6
Joseph Safdieh, Babak Givi, Virginia Osborn, Ariel Lederman, David Schwartz, David Schreiber
Objective Using the National Cancer Database (NCDB), we investigated the characteristics, outcomes, and benefits of adjuvant therapy for patients diagnosed with malignant salivary gland tumors between 2004 and 2012. Study Design Retrospective analysis. Setting NCDB. Subject and Methods The cases of patients diagnosed with a nonmetastatic major salivary gland tumor who underwent resection between 2004 and 2012 were abstracted from the NCDB. Patients were further included if they had pT1-4NX-1M0 high-grade disease or pT3-4NX-0M0 or pT1-4N1M0 low-grade disease...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28671024/prospective-pilot-study-comparing-the-need-for-adaptive-radiotherapy-in-unresected-bulky-disease-and-in-postoperative-patients-with-head-and-neck-cancer
#7
Omar Mahmoud, Isildinha M Reis, Michael M Samuels, Nagy Elsayyad, Elizabeth Bossart, Joseph Both, Ehsan ELGhoneimy, Magda Moustafa, Mohamed AbdAllah, Cristiane Takita
BACKGROUND: Adaptive radiotherapy is being used in few institutions in patients with head and neck cancer having bulky disease using periodic computed tomography imaging accounting for volumetric changes in tumor volume and/or weight loss. Limited data are available on ART in the postoperative setting. We aim to identify parameters that would predict the need for ART in patients with head and neck cancer and whether ART should be applied in postoperative setting. MATERIALS AND METHODS: Twenty patients with stage III-IV head and neck cancer were prospectively accrued...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28655435/primary-epithelial-salivary-gland-tumours-in-children-and-adolescents
#8
M Gontarz, G Wyszyńska-Pawelec, J Zapała
Primary epithelial tumours of the salivary glands are very rare in paediatric patients. The aim of this study was to evaluate the clinical course, treatment, and outcomes of these uncommon neoplasms based on the authors' experience and the recent literature. The medical charts of 12 female patients and seven male patients with primary epithelial salivary gland tumours were reviewed. All were under 19 years of age and underwent surgical treatment between 1994 and 2016. The results of this group of paediatric patients were compared with those of 621 adult patients...
June 24, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28640094/effects-of-first-radioiodine-ablation-on-functions-of-salivary-glands-in-patients-with-differentiated-thyroid-cancer
#9
Arun Upadhyaya, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Pingping Zhou, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan
The aim of this study was to evaluate the effects of the first radioactive iodine (I) therapy on functions of salivary glands in patients with differentiated thyroid carcinoma (DTC).There were 36 consented patients with DTC enrolled in this study, who received 3.7 GBq (100mCi) I for ablation after total thyroidectomy. Salivary gland function was assessed using salivary gland scintigraphy in two phases, one 4 hours before and the other 6 months after I therapy (both under thyrotropin stimulation condition)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28628803/mucoepidermoid-carcinoma-associated-expression-of-muc5ac-muc5b-and-mucin-type-carbohydrate-antigen-sialyl-tn-in-the-parotid-gland
#10
Johannes H Matse, Wiresh K Bharos, Enno C I Veerman, Elisabeth Bloemena, Jan G M Bolscher
OBJECTIVES: The aberrant expression of mucins and mucin-type carbohydrates has been described in many types of cancer, including mucoepidermoid carcinoma (MEC), a malignant salivary gland tumor. In this study, we examined the aberrant expression patterns of mucins (MUC1, MUC4, MUC5AC and MUC5B), simple mucin-type carbohydrate antigens (Tn, sialyl-Tn and T) and mature carbohydrate antigens (Lewis(a) and sulfo-Lewis(a) antigens) in MEC originating from the parotid gland, which normally does not secrete mucins...
June 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28613198/lu-177-psma-617-prostate-specific-membrane-antigen-inhibitor-therapy-in-patients-with-castration-resistant-prostate-cancer-stability-bio-distribution-and-dosimetry
#11
Levent Kabasakal, Türkay Toklu, Nami Yeyin, Emre Demirci, Mohammad Abuqbeitah, Meltem Ocak, Aslan Aygün, Emre Karayel, Hüseyin Pehlivanoğlu, Nalan Alan Selçuk
OBJECTIVE: The aim of the study was to estimate the radiation-absorbed doses and to study the in vivo and in vitro stability as well as pharmacokinetic characteristics of lutetium-177 (Lu-177) prostate-specific membrane antigen (PSMA)-617. METHODS: For this purpose, 7 patients who underwent Lu-177-PSMA therapy were included into the study. The injected Lu-177-PSMA-617 activity ranged from 3.6 to 7.4 GBq with a mean of 5.2±1.8 GBq. The stability of radiotracer in saline was calculated up to 48 h...
June 1, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28588778/rexin-g-%C3%A2-a-tumor-targeted-retrovector-for-malignant-peripheral-nerve-sheath-tumor-a-case-report
#12
Seth Kim, Noah Federman, Erlinda M Gordon, Frederick L Hall, Sant P Chawla
Soft tissue sarcoma is a rare neoplasm of mesenchymal origin, accounting for only ~1% of all adult cancers and consisting of 75 histological subtypes. In the present report, the unique case of a 14 year-old female with metastatic malignant peripheral nerve sheath tumor (formerly, malignant melanotic schwannoma) of the parotid gland, who experienced a durable response and sustained tumor control with Rexin-G(®), a tumor-targeted retroviral expression vector encoding an anti-cyclin G1 construct, is described...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28555505/comparison-of-dose-distribution-for-head-and-neck-cancer-patients-with-and-without-dose-painting-escalation-during-radiotherapy-realized-with-tomotherapy-unit
#13
COMPARATIVE STUDY
Malgorzata Skorska, Tomasz Piotrowski, Adam Ryczkowski
OBJECTIVE: To determine and quantify the percentage dose increase to organs at risk (OARs) with multiple-level dose painting (DP) for patients with head and neck cancer in comparison with standard regimen. METHODS: 12 patients who had undergone fluorine-18 fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT scan were retrospectively enrolled. Two treatment plans-one using DP escalation and one without-were optimized for each patient base on PET/CT data...
July 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28541247/lymphoid-tissue-neoplasms-in-the-neck-region-epidemiological-and-clinical-analysis-over-15-years
#14
Anna Rzepakowska, Klaudyna Zwierzyńska, Ewa Osuch-Wójcikiewicz, Kazimierz Niemczyk
AIM: Epidemiological and clinical analysis of lymphoid tissue neoplasms in the neck region over a 15-year period. MATERIAL: There was performed retrospective analysis of 97 patients, aged 17 to 88 years, mean age of 60.3 years. The analysis included data from subjective study, physical examination, image and histopathological studies Results: Almost all cases were lymphoid neoplasms - 95 patients (98%). B cell lymphoma was the most commonly diagnosed lymphoma - 74 cases (76%), followed by Hodgkin's lymphoma- 19 cases (20%)...
June 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28530137/intravoxel-incoherent-motion-magnetic-resonance-imaging-of-the-normal-appearing-parotid-glands-in-patients-with-differentiated-thyroid-cancer-after-radioiodine-therapy
#15
Jie Shen, Xiao-Quan Xu, Guo-Yi Su, Hao Hu, Hai-Bin Shi, Wei Liu, Fei-Yun Wu
Background Radiation damage to the salivary gland is a common complication of radioiodine therapy (RIT) in the patients with differentiated thyroid cancer (DTC). Purpose To investigate the feasibility of using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) to detect radiation-induced changes of normal-appearing parotid glands in the patients after RIT for DTC. Material and Methods We prospectively enrolled 20 patients with RIT-induced sialoadenitis and 20 healthy control (HC) participants...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28529250/impact-of-jaw-position-accuracy-on-dose-variation-in-volumetric-modulated-arc-therapy-using-jaw-tracking
#16
Fumiyasu Matsubayashi, Yuki Koizumi, Ryo Takahashi, Minoru Yoshioka, Tomoharu Sato
The technique of jaw tracking can be used in volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT). In this technique, jaw tracks apertures of the multi leaf collimator (MLC) during irradiation. It is reported that dose variation is occurred by the changing accuracy of MLC position in VMAT and IMRT. Though jaw moves dynamically in the irradiation by using this technique, the influence of the jaw position accuracy on dose variation is not examined. The purpose of this study is to verify the influence of jaw position accuracy on dose variation in VMAT using jaw tracking...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28508845/dosimetric-comparison-of-head-and-neck-cancer-patients-planned-with-multivendor-volumetric-modulated-arc-therapy-technology
#17
Murugesan Kathirvel, Vellaiyan Subramani, V S Subramanian, Shanmugam Thirumalai Swamy, Gandhi Arun, Subramanian Kala
AIM: Purpose of this study is to dosimetrically compare head and neck (H and N) cancer patients planned with multivendor volumetric modulated arc therapy (VMAT) technology. VMAT treatment planning can be done using biological (treatment planning system [TPSB]: Monaco) or physical (TPSP: Eclipse)-based cost function optimization techniques. Planning and dosimetric comparisons were done in both techniques for H and N cases. MATERIALS AND METHODS: Twenty H and N patients were retrospectively selected for this study...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28502238/parotid-gland-mean-dose-as-a-xerostomia-predictor-in-low-dose-domains
#18
Hubert Szymon Gabryś, Florian Buettner, Florian Sterzing, Henrik Hauswald, Mark Bangert
PURPOSE: Xerostomia is a common side effect of radiotherapy resulting from excessive irradiation of salivary glands. Typically, xerostomia is modeled by the mean dose-response characteristic of parotid glands and prevented by mean dose constraints to either contralateral or both parotid glands. The aim of this study was to investigate whether normal tissue complication probability (NTCP) models based on the mean radiation dose to parotid glands are suitable for the prediction of xerostomia in a highly conformal low-dose regime of modern intensity-modulated radiotherapy (IMRT) techniques...
May 13, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28495444/comparing-the-rtog-eortc-and-lent-soma-scoring-systems-for-the-evaluation-of-late-skin-toxicity-after-125-i-seed-brachytherapy-for-parotid-gland-cancer
#19
Ming-Hui Mao, Zhien Feng, Hua Li, Li-Zheng Qin, Jian-Hua Li, Xin Huang, Ru-Dong Xing, Jie Zhang, Jian-Guo Zhang, Zheng-Xue Han
PURPOSE: The Radiation Therapy Oncology Group (RTOG) and Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic (LENT-SOMA) scoring systems were compared for grading late skin effects after iodine-125 seed brachytherapy in parotid gland cancer patients. METHODS AND MATERIALS: A total of 109 patients diagnosed with parotid gland carcinoma were treated postoperatively with iodine-125 seed brachytherapy at a dose of 100-120 Gy. After 6-24 months of followup, telangiectasia, skin pigmentation, atrophy, fibrosis, and ulceration were scored according to both RTOG and LENT-SOMA scale criteria...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28485299/increase-in-the-incidence-of-parotid-gland-tumors-in-the-years-2005-2014
#20
Grażyna Stryjewska-Makuch, Bogdan Kolebacz, Małgorzata A Janik, Agnieszka Wolnik
INTRODUCTION: Salivary gland tumours account for 3-6% of tumours of the head and neck. About 80% of salivary gland tumors occur in parotid glands, 10-17% of which are malignant The aim of the study was to assess whether there is an upward trend in cancer incidence within the parotid glands, with particular emphasis on cancers. MATERIALS AND METHODS: 322 patients underwent surgery and 328 parotid gland tumours were removed in the years 2005-2014 at the Department of Laryngology and Laryngological Oncology of the Upper Silesian Medical Centre in Katowice-Ochojec...
April 30, 2017: Otolaryngologia Polska
keyword
keyword
22436
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"