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parotid cancer

Akira Nishikado, Ryo Kawata, Shin-Ichi Haginomori, Tetsuya Terada, Masaaki Higashino, Yoshitaka Kurisu, Yoshinobu Hirose
BACKGROUND: This study investigated the clinical outcomes of patients with parotid carcinoma at a single institution during an 18-year period, with the focus on diagnosis, treatment, and survival. METHODS: The subjects were 171 patients with parotid carcinoma treated at our department during the 18-year period from September 1999 to August 2017. There were 19 patients in stage I, 65 patients in stage II, 22 patients in stage III, and 65 patients in stage IV. The symptoms, preoperative diagnosis, node metastasis, survival rate, prognostic factors, and immunohistological findings were investigated...
March 21, 2018: International Journal of Clinical Oncology
Karthik Rajasekaran, Vanessa Stubbs, Jinbo Chen, Pratyusha Yalamanchi, Steven Cannady, Jason Brant, Jason Newman
OBJECTIVE: To describe the demographics, tumor characteristics, and prognostic features of mucoepidermoid carcinoma of the parotid gland. MATERIALS AND METHODS: A retrospective study of the National Cancer Database was reviewed for all mucoepidermoid carcinomas of the parotid gland between 2004 and 2012). Patient demographics and tumor characteristics were abstracted and analyzed. Univariate and multivariate Cox multivariate regression models were used to identify predictors of survival...
March 14, 2018: American Journal of Otolaryngology
Hubert S Gabryś, Florian Buettner, Florian Sterzing, Henrik Hauswald, Mark Bangert
Purpose: The purpose of this study is to investigate whether machine learning with dosiomic, radiomic, and demographic features allows for xerostomia risk assessment more precise than normal tissue complication probability (NTCP) models based on the mean radiation dose to parotid glands. Material and methods: A cohort of 153 head-and-neck cancer patients was used to model xerostomia at 0-6 months (early), 6-15 months (late), 15-24 months (long-term), and at any time (a longitudinal model) after radiotherapy...
2018: Frontiers in Oncology
Enzo Emanuelli, Andrea Ciorba, Daniele Borsetto, Diego Cazzador, Samantha Sarcognato, Filippo Marino, Stefano Fusetti, Chiara Bianchini, Francesco Stomeo, Stefano Pelucchi
PURPOSE: Most primary tumors spreading metastasis to the parotid gland are usually located in the head and neck region, nonetheless, rarely, parotid gland can also be the target of metastatic localization site of distant primary tumors. The purpose of this study was to describe a clinical series of metastasis to the parotid gland from distant primary tumors (non Head & Neck). METHODS: The clinical databases of parotid tumors in two academic centers have been analyzed and 11 cases of parotid metastatic cancers from distant primary tumors were found...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Nir Hirshoren, Olivia Ruskin, Lachlan J McDowell, Matthew Magarey, Stephen Kleid, Benjamin J Dixon
Objectives Extent of parotidectomy and neck dissection for metastatic cutaneous squamous cell carcinoma (cSCC) to the parotid is debated. We describe our experience, analyzing outcomes (overall survival and regional recurrence) associated with surgical extent and adjuvant treatment. Study Design A retrospective cohort study of parotidectomy with or without neck dissection for metastatic cSCC. Setting A tertiary referral cancer center in Australia. Subjects and Methods The study group consisted of patients with metastatic cSCC involving the parotid gland who underwent a curative-intent parotidectomy (superficial or total), with or without neck dissection, between 2003 and 2014...
March 1, 2018: Otolaryngology—Head and Neck Surgery
Thomas J W Klein Nulent, Matthijs H Valstar, Bart de Keizer, Stefan M Willems, Laura A Smit, Abrahim Al-Mamgani, Ludwig E Smeele, Robert J J van Es, Remco de Bree, Wouter V Vogel
OBJECTIVES: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is used for detection and (re)staging of prostate cancer. However, healthy salivary, seromucous, and lacrimal glands also have high PSMA-ligand uptake. This study aimed to describe physiologic PSMA-ligand uptake distribution characteristics in the head and neck to aid in PSMA PET/CT interpretation and to identify possible new clinical applications for PSMA-ligand imaging. STUDY DESIGN: Thirty consecutive patients who underwent PSMA PET/CT for prostate cancer were evaluated...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Donika Plyku, Esther Mena, Steven P Rowe, Martin A Lodge, Zsolt Szabo, Steve Y Cho, Martin G Pomper, George Sgouros, Robert F Hobbs
PURPOSE: Prostate-specific membrane antigen (PSMA), a type-II integral membrane protein highly expressed in prostate cancer, has been extensively used as a target for imaging and therapy. Among the available PET radiotracers, the low molecular weight agents that bind to PSMA are proving particularly effective. We present the dosimetry results for18 F-DCFPyL in nine patients with metastatic prostate cancer. METHODS: Nine patients were imaged using sequential PET/CT scans at approximately 1, 12, 35 and 70 min, and a final PET/CT scan at approximately 120 min after intravenous administration of 321 ± 8 MBq (8...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Hiroaki Watanabe, Takuya Odagiri, Yasuyuki Asai
CONTEXT: Acute suppurative sialadenitis (hereafter referred to as sialadenitis) is accompanied by pain and fever and can diminish the quality of life (QOL) in end-stage cancer patients; however, its incidence is not clear. OBJECTIVES: We conducted this study to elucidate the incidence of sialadenitis in end-stage cancer patients. METHODS: Retrospective review, observational study based on patients' medical records SUBJECTS: 726 consecutive cancer patients who died on the palliative care unit of our hospital between April 2012 and November 2016 were included...
February 14, 2018: Journal of Pain and Symptom Management
B J Rocca, A Gini, C Calandra, A Ginori, F Crivelli
Malignancies of the parotid gland are relatively uncommon, accounting for only 3-6% of all head and neck cancers. Most of them are primary neoplasms, metastases are uncommon. Renal cell carcinoma (RCC) represents 3% of adult malignancies, the clear cell type comprises up to 70% of all RCC. RCC has an unpredictable behavior and the unique potential to metastasize to nearly every organ in the body. Though not as frequent, metastatic RCC to the head and neck has been identified in the thyroid, salivary glands, skull base, sinuses, pharynx, tonsils, tongue, lip and skin...
December 2017: Pathologica
Shaohuan Lin, Junhong Lv, Panli Peng, Changqing Cai, Jianming Deng, Haihong Deng, Xuejun Li, Xinyue Tang
Bufadienolides are a type of cardiotonic steroids isolated from the skin and parotid venom glands of the toad Bufo bufo gargarizans Cantor, and exhibit wide-spectrum anticancer activities. However, the effects and mechanisms of bufadienolides on esophageal squamous cell carcinoma (ESCC) cells remain unknown. In the present study, the anticancer activities of two bufadienolides, bufotalin and bufalin, were examined in vitro and in vivo . The results demonstrated that bufotalin and bufalin effectively inhibited the viability of ESCC cells, with half-maximal inhibitory concentration (IC50 ) values of 0...
February 2018: Oncology Letters
Nusrat Begum, Anne Thieme, Nina Eberhardt, Robert Tauber, Ambros J Beer, Gerhard Glatting, Matthias Eiber, Peter Kletting
Aim: To simulate the effect of PSMA positive total tumor volume (TTV) on the tumor and organs at risk (OARs) biologically effective doses (BEDs) in patients with metastatic castration resistant prostate cancer (mCRPC) in 177Lu-PSMA radioligand therapy. Methods: A physiologically-based pharmacokinetic model was fitted to data of 13 patients treated with 177Lu-PSMA I&T. The tumor, kidneys and salivary glands BEDs were simulated for TTVs of 0.1-10 l. The activity and peptide amounts leading to an optimal tumor-to-kidneys BED ratio were also investigated...
February 1, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Ming-Hui Mao, Jie Zhang, Jian-Guo Zhang
No abstract text is available yet for this article.
January 2018: Brachytherapy
Hsiao-Fei Lee, Jen-Hong Lan, Pei-Ju Chao, Hui-Min Ting, Hui-Chun Chen, Hsuan-Chih Hsu, Tsair-Fwu Lee
Background: Patients treated with radiotherapy are at risk of developing a second cancer during their lifetime, which can directly impact treatment decision-making and patient management. The aim of this study was to qualify and compare the secondary cancer risk (SCR) after intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) in nasopharyngeal carcinoma (NPC) patients. Patients and methods: We analyzed the treatment plans of a cohort of 10 NPC patients originally treated with IMRT or VMAT...
2018: Cancer Management and Research
Terufumi Kawamoto, Keiji Nihei, Yujiro Nakajima, Satoshi Kito, Keisuke Sasai, Katsuyuki Karasawa
OBJECTIVE: In the treatment of head-neck cancer, parotid-sparing intensity-modulated radiotherapy (IMRT) could reduce the incidence of xerostomia. When the parotid glands cannot be sufficiently spared because of the widespread tumor, contralateral superficial lobe parotid-sparing (CSLPS)-IMRT could be used to reduce marginal recurrence, however the success of this approach remains to be determined. The primary purpose of this study was to compare the incidence of xerostomia between three-dimensional conformal radiotherapy (3D-CRT) and CSLPS-IMRT for oropharyngeal and hypopharyngeal cancer...
January 31, 2018: Auris, Nasus, Larynx
Yuliang Jiang, Zhe Ji, Fuxin Guo, Ran Peng, Haitao Sun, Jinghong Fan, Shuhua Wei, Weiyan Li, Kai Liu, Jinghua Lei, Junjie Wang
BACKGROUND: For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-planar template (3D-PNCT) for computed tomography (CT)-guided radioactive125 I seed (RIS) implantation in recurrent cancer of the head and neck. METHODS: Between January 2016 and December 2016, forty-two patients with local recurrent malignant tumors of the head and neck received 3D-PNCT-assisted RIS implantation...
February 3, 2018: Radiation Oncology
Richard P Baum, Thomas Langbein, Aviral Singh, Mostafa Shahinfar, Christiane Schuchardt, Gerd Fabian Volk, Harshad Kulkarni
The dose-limiting salivary gland toxicity of 225Ac-labelled PSMA for treatment of metastatic, castration-resistant prostate cancer remains unresolved. Suppressing the metabolism of the gland by intraparenchymal injections of botulinum toxin appears to be a promising method to reduce off-target uptake. A 68Ga-PSMA PET/CT scan performed 45 days after injection of 80 units of botulinum toxin A into the right parotid gland in a 63-year-old patient showed a decrease in the SUVmean in the right parotid gland of up to 64% as compared with baseline...
February 2018: Nuclear Medicine and Molecular Imaging
Stanley K Woo, Chad Freeman, Brock J Debenham
Introduction Advanced-stage oropharyngeal cancer can be treated with primary chemoradiation (CRT) or primary surgery with adjuvant radiotherapy, both with similar survival outcomes. Though primary CRT prescribes a higher dose, adjuvant radiation requires irradiating the surgical bed, which may increase the high dose planned target volume (PTV). We hypothesize that the integral dose to the neck and dose to critical structures will be lower with primary CRT than adjuvant radiotherapy. Methods We selected the last 18 patients who underwent surgery and adjuvant radiotherapy at one institution between July 2015 and August 2016 with American Joint Committee on Cancer (AJCC) stage III or IVA oropharyngeal squamous cell cancer...
November 17, 2017: Curēus
Karim Mashhour, Maha Kamaleldin, Wedad Hashem
Purpose: The aim of this study was to dosimetrically evaluate and compare double arc RapidArc (RA) with conventional IMRT (7 fields) plans for irradiation of locally advanced head and neck cancers (LAHNC), focusing on target coverage and doses received by organs at risk (OAR). Methods: Computed tomography scans of 20 patients with LAHNC were obtained. Contouring of the target volumes and OAR was done. Two plans were made for each patient, one using IMRT and the other double arc RA, and calculated doses to planning target volume (PTV) and OAR were compared...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Valerio Nardone, Paolo Tini, Christophe Nioche, Maria Antonietta Mazzei, Tommaso Carfagno, Giuseppe Battaglia, Pierpaolo Pastina, Roberta Grassi, Lucio Sebaste, Luigi Pirtoli
PURPOSE: Image texture analysis (TA) is a heterogeneity quantifying approach that cannot be appreciated by the naked eye, and early evidence suggests that TA has great potential in the field of oncology. The aim of this study is to evaluate parotid gland texture analysis (TA) combined with formal dosimetry as a factor for predicting severe late xerostomia in patients undergoing radiation therapy for head and neck cancers. METHODS: We performed a retrospective analysis of patients treated at our Radiation Oncology Unit between January 2010 and December 2015, and selected the patients whose normal dose constraints for the parotid gland (mean dose < 26 Gy for the bilateral gland) could not be satisfied due to the presence of positive nodes close to the parotid glands...
January 24, 2018: La Radiologia Medica
Phillip Huyett, Umamaheswar Duvvuri, Robert L Ferris, Jonas T Johnson, Barry M Schaitkin, Seungwon Kim
Objectives To investigate the clinical predictors and survival implications of perineural invasion (PNI) in parotid gland malignancies. Study Design Case series with chart review. Setting Tertiary care medical center. Subjects and Methods Patients with parotid gland malignancies treated surgically from 2000 to 2015 were retrospectively identified in the Head and Neck Cancer Registry at a single institution. Data points were extracted from the medical record and original pathology reports. Results In total, 186 patients with parotid gland malignancies were identified with a mean follow-up of 5...
January 1, 2018: Otolaryngology—Head and Neck Surgery
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