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https://www.readbyqxmd.com/read/28430080/generation-and-characterization-of-inhibitory-antibodies-specific-to-guinea-pig-cxcr1-and-cxcr2
#1
Kento Tanaka, Chigusa Yoshimura, Tetsuo Shiina, Tomoko Terauchi, Tomomi Yoshitomi, Kazuki Hirahara
CXCR1 and CXCR2 are chemokine receptors that have different selectivity of chemokine ligands, but the distinct role of each receptor is not clearly understood. This is due to the absence of specific inhibitors in guinea pigs, which are the appropriate species for investigation of CXCR1 and CXCR2 because of their functional similarity to humans. In this study, we generated and evaluated monoclonal antibodies that specifically bound to guinea pig CXCR1 (gpCXCR1) and guinea pig CXCR2 (gpCXCR2) for acquisition of specific inhibitors...
April 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28430079/monoclonal-antibody-abcr1-against-guinea-pig-cxcr1-and-monoclonal-antibody-abcr2-against-guinea-pig-cxcr2
#2
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28429504/induced-pluripotent-stem-cells-reduce-neutrophil-chemotaxis-via-activating-grk2-in-endotoxin-induced-acute-lung-injury
#3
Vincent Yi-Fong Su, Shih-Hwa Chiou, Chi-Shiuan Lin, Wei-Chih Chen, Wen-Kuang Yu, Yen-Wen Chen, Cheng-Yu Chen, Kuang-Yao Yang
BACKGROUND AND OBJECTIVE: We investigated the effect of induced pluripotent stem cells (iPSCs) in moderating neutrophil chemotaxis in endotoxin-induced acute lung injury (ALI). METHODS: Male C57BL/6 mice at 8-12 weeks of age were studied. Murine iPSCs were delivered through the tail veins of mice 4 h after intratracheal instillation of endotoxin. Lung histopathological findings, neutrophil counts in peripheral blood and bronchoalveolar lavage fluid (BALF), bone marrow (BM) cell distribution, expression of chemokine receptors and regulatory signalling pathways were analysed after 24 h...
April 21, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28423567/cxcr1-2-pathways-in-paclitaxel-induced-neuropathic-pain
#4
Brandolini Laura, Benedetti Elisabetta, Ruffini Pier Adelchi, Russo Roberto, Cristiano Loredana, Antonosante Andrea, d'Angelo Michele, Castelli Vanessa, Giordano Antonio, Allegretti Marcello, Cimini Annamaria
Chemotherapy-induced peripheral neuropathy (CIPN) is a type of neuropathic pain that represents a frequent and serious consequence of chemotherapy agents. Over the last years, significant progress has been achieved in elucidating the underlying pathogenesis of CIPN. The interference of taxanes with microtubule has been proposed as a mechanism that leads to altered axonal transport and to permanent neurological damages. The inflammatory process activated by chemotherapeutic agents has been considered as a potential trigger of nociceptive process in CIPN...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423359/epithelial-mesenchymal-transition-induced-by-gro-%C3%AE-cxcr2-promotes-bladder-cancer-recurrence-after-intravesical-chemotherapy
#5
Lu Chen, Xiu-Wu Pan, Hai Huang, Yi Gao, Qi-Wei Yang, Lin-Hui Wang, Xin-Gang Cui, Dan-Feng Xu
Non-muscle invasive bladder cancers (NMIBC) are typically treated by transurethral resection with intravesical chemotherapy. However, the post-therapeutic incidence of tumor recurrence and progression to muscle invasive disease is high, and the underlying mechanism(s) remains unknown. In this study, we observed that recurrent bladder cancer cells exhibit a mesenchymal phenotype, which is initiated by the autocrine GRO-α signaling. Mechanically, the chemotherapeutic drug epidoxorubicin induces GRO-α expression in primary bladder cancer cells at G1/S phase via p38-dependent activation of NF-κB...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420714/pancreatic-islet-inflammation-an-emerging-role-for-chemokines
#6
J Jason Collier, Tim E Sparer, Michael D Karlstad, Susan J Burke
Both Type 1 and Type 2 diabetes exhibit features of inflammation associated with alterations in pancreatic islet function and mass. These immunological disruptions, if unresolved, contribute to the overall pathogenesis of disease onset. This review presents the emerging role of pancreatic islet chemokine production as a critical factor regulating immune cell entry into pancreatic tissue as well as an important facilitator of changes in tissue resident leukocyte activity. Signaling through two specific chemokine receptors (i...
April 18, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28418782/knockdown-of-il-8-provoked-premature-senescence-of-placenta-derived-mesenchymal-stem-cells
#7
Juan-Juan Li, Feng-Xia Ma, You-Wei Wang, Fang Chen, Shi-Hong Lu, Ying Chi, Wen-Jing Du, Bao-Quan Song, Liang-Ding Hu, Hu Chen, Zhong-Chao Han
Mesenchymal stem cells (MSCs) have shown promise for use in cell therapy, and due to their tumor tropism can serve as vehicles for delivering therapeutic agents to tumor sites. Because interleukin-8 (IL-8) is known to mediate the protumor effect of MSCs, elimination of IL-8 secretion by MSCs may enhance their safety for use in cancer gene therapy. However, little is known concerning the effect of endogenously secreted IL-8 on MSCs. We performed studies using placenta-derived MSCs (PMSCs) to determine whether knockdown of IL-8 would influence their biological activity...
April 18, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28416308/implantation-of-endothelial-cells-with-mesenchymal-stem-cells-accelerates-dental-pulp-tissue-regeneration-healing-in-pulpotomized-rat-molars
#8
Yukiko Sueyama, Tomoatsu Kaneko, Takafumi Ito, Reika Kaneko, Takashi Okiji
INTRODUCTION: This study aimed to examine whether the implantation of mesenchymal stem cells (MSCs) with endothelial cells (ECs) accelerates pulp tissue regeneration/healing and induces dentin bridge formation in a rat model of molar coronal pulp regeneration. METHODS: The maxillary first molars of Wistar rats were subjected to pulpotomy. Then, pulp chambers were implanted with biodegradable hydrogel-made scaffolds carrying MSCs together or without dermal microvascular ECs, and the cavities were sealed with mineral trioxide aggregate...
April 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28415830/triptolide-mitigates-radiation-induced-pneumonitis-via-inhibition-of-alveolar-macrophages-and-related-inflammatory-molecules
#9
Chun Chen, Shanmin Yang, Mei Zhang, Zhenhuan Zhang, Steven B Zhang, Bing Wu, Jinsheng Hong, Weijian Zhang, Jianhua Lin, Paul Okunieff, Lurong Zhang
Ionizing radiation-induced pulmonary injury is a major limitation of radiotherapy for thoracic tumors. We have demonstrated that triptolide (TPL) could alleviate IR-induced pneumonia and pulmonary fibrosis. In this study, we explored the underlying mechanism by which TPL mitigates the effects of radiotoxicity. The results showed that:(1) Alveolar macrophages (AMs) were the primary inflammatory cells infiltrating irradiated lung tissues and were maintained at a high level for at least 17 days, which TPL could reduce by inhibiting of the production of macrophage inflammatory protein-2 (MIP-2) and its receptor CXCR2...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415702/overexpression-of-cxcr2-predicts-poor-prognosis-in-patients-with-colorectal-cancer
#10
Jingkun Zhao, Baochi Ou, Hao Feng, Puxiongzhi Wang, Shuai Yin, Congcong Zhu, Shenjie Wang, Chun Chen, Minhua Zheng, Yaping Zong, Jing Sun, Aiguo Lu
Colorectal cancer is a heterogeneous disease. Although many risk factors are used to predict colorectal cancer patients' prognosis after surgical resection, new prognostic factors are still needed to be defined to promote predictive efficacy of prognosis and further guide therapies. Herein, we identified the prognostic significance of CXCR2 in colorectal cancer patients. We retrospectively analysed 134 patients with colorectal cancer who underwent minimally invasive surgery between 2010 and 2011. The overall cohort was divided into a training set (n = 78) and a validation set (n = 56)...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415590/multiple-anti-tumor-effects-of-reparixin-on-thyroid-cancer
#11
Federica Liotti, Maria De Pizzol, Marcello Allegretti, Nella Prevete, Rosa Marina Melillo
BACKGROUND: Expression of IL-8 and its receptors CXCR1 and CXCR2 is a common occurrence in human epithelial thyroid cancer (TC). In human TC samples, IL-8 expression is associated with tumor progression. IL-8 enhances proliferation, survival, motility, and leads to the maintenance of stemness features and tumor-initiating ability of TC cells. Here, we studied the effects of Reparixin (formerly Repertaxin), a small molecular weight CXCR1 and CXCR2 inhibitor, on the malignant phenotype of various TC cell lines...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28393868/corrigendum-cxcr2-deficient-mice-display-macrophage-dependent-exaggerated-acute-inflammatory-responses
#12
Douglas P Dyer, Kenneth Pallas, Laura Medina-Ruiz, Fabian Schuette, Gillian J Wilson, Gerard J Graham
No abstract text is available yet for this article.
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389721/chemokines-in-neuron-glial-cell-interaction-and-pathogenesis-of-neuropathic-pain
#13
REVIEW
Zhi-Jun Zhang, Bao-Chun Jiang, Yong-Jing Gao
Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly debilitating chronic pain state and is often resistant to currently available treatments. It has become clear that neuroinflammation, mainly mediated by proinflammatory cytokines and chemokines, plays an important role in the establishment and maintenance of neuropathic pain. Chemokines were originally identified as regulators of peripheral immune cell trafficking and were also expressed in neurons and glial cells in the central nervous system...
April 7, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28387853/cxcl8-antagonist-improves-diabetic-nephropathy-in-male-mice-of-diabetes-and-attenuates-high-glucose-induced-mesangial-injury
#14
Siyuan Cui, Yujie Zhu, Jianling Du, Muhammad Noman Khan, Bing Wang, Jing Wei, Jya-Wei Cheng, John R Gordon, Yutian Mu, Fang Li
Inflammation is recognized as a crucial contribution to diabetic nephropathy (DN). CXCL8 binds to its CXC chemokine receptors (CXCR1 and CXCR2) for recruiting neutrophils infiltration and initiates tissue inflammation. Therefore, we explored the effect of CXCR1 and CXCR2 inhibition on diabetic nephropathy. This was achieved by CXCL8 (3-72) K11R/G31P (G31P), an antagonist of CXCL8, which has exhibited therapeutic efficacy in inflammatory diseases and malignancies. In this study, we found renal leukocytes accumulation and rapid increases of CXCL8 occurred in HFD/STZ-induced diabetic mice...
April 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/28387445/stimulation-of-oral-fibroblast-chemokine-receptors-identifies-ccr3-and-ccr4-as-potential-wound-healing-targets
#15
Jeroen Kees Buskermolen, Sanne Roffel, Susan Gibbs
The focus of this study was to determine which chemokine receptors are present on oral fibroblasts and whether these receptors influence proliferation, migration and/or the release of wound healing mediators. This information may provide insight into the superior wound healing characteristics of the oral mucosa. The gingiva fibroblasts expressed 12 different chemokine receptors (CCR3, CCR4, CCR6, CCR9, CCR10, CXCR1, CXCR2, CXCR4, CXCR5, CXCR7, CX3CR1 and XCR1), as analyzed by flow cytometry. Fourteen corresponding chemokines (CCL5, CCL15, CCL20, CCL22, CCL25, CCL27, CCL28, CXCL1, CXCL8, CXCL11, CXCL12, CXCL13, CX3CL1 and XCL1) were used to study the activation of these receptors on gingiva fibroblasts...
April 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28385810/regulation-of-p53-mediated-changes-in-the-upa-fibrinolytic-system-and-in-lung-injury-by-loss-of-surfactant-protein-c-expression-in-alveolar-epithelial-cells
#16
Bijesh Puthusseri, Amarnath S Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shetty
Pulmonary surfactant protein-C (SP-C) expression by type II alveolar epithelial cells (AECs) is markedly reduced in diverse types of lung injuries and is often associated with AEC apoptosis. It is unclear whether loss of SP-C contributes to the increased p53 and urokinase-type plasminogen activator (uPA) system cross talk and apoptosis of AECs. We therefore inhibited SP-C expression in human and murine AECs using lentivirus vector expressing shRNA and tested p53 and downstream changes in uPA-fibrinolytic system...
April 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28385737/lack-of-stat6-attenuates-inflammation-and-drives-protection-against-early-steps-of-colitis-associated-colon-cancer
#17
Sonia A Leon-Cabrera, Emmanuel Molina-Guzman, Yael G Delgado-Ramirez, Armando Vázquez-Sandoval, Yadira Ledesma-Soto, Carlos G Pérez-Plasencia, Yolanda I Chirino, Norma L Delgado-Buenrostro, Miriam Rodríguez-Sosa, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Emma B Gutierrez-Cirlos, Luis E Arias-Romero, Luis I Terrazas
Colitis-associated colon cancer (CAC) is one of the most common malignant neoplasms and a leading cause of death. The immunologic factors associated with CAC development are not completely understood. Signal transducer and activator of transcription 6 (STAT6) is part of an important signaling pathway for modulating intestinal immune function and homeostasis. However, the role of STAT6 in colon cancer progression is unclear. Following CAC induction in wild-type (WT) and STAT6-deficient mice (STAT6(-/-)), we found that 70% of STAT6(-/-) mice were tumor-free after 8 weeks, whereas 100% of WT mice developed tumors...
April 6, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28368308/chemokine-cxcl7-heterodimers-structural-insights-cxcr2-receptor-function-and-glycosaminoglycan-interactions
#18
Aaron J Brown, Prem Raj B Joseph, Kirti V Sawant, Krishna Rajarathnam
Chemokines mediate diverse fundamental biological processes, including combating infection. Multiple chemokines are expressed at the site of infection; thus chemokine synergy by heterodimer formation may play a role in determining function. Chemokine function involves interactions with G-protein-coupled receptors and sulfated glycosaminoglycans (GAG). However, very little is known regarding heterodimer structural features and receptor and GAG interactions. Solution nuclear magnetic resonance (NMR) and molecular dynamics characterization of platelet-derived chemokine CXCL7 heterodimerization with chemokines CXCL1, CXCL4, and CXCL8 indicated that packing interactions promote CXCL7-CXCL1 and CXCL7-CXCL4 heterodimers, and electrostatic repulsive interactions disfavor the CXCL7-CXCL8 heterodimer...
April 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28356111/tumor-derived-cxcl5-promotes-human-colorectal-cancer-metastasis-through-activation-of-the-erk-elk-1-snail-and-akt-gsk3%C3%AE-%C3%AE-catenin-pathways
#19
Jingkun Zhao, Baochi Ou, Dingpei Han, Puxiongzhi Wang, Yaping Zong, Congcong Zhu, Di Liu, Minhua Zheng, Jing Sun, Hao Feng, Aiguo Lu
BACKGROUND: Metastasis is a major cause of death in human colorectal cancer patients. However, the contribution of chemokines in the tumor microenvironment to tumor metastasis is not fully understood. METHODS: Herein, we examinined several chemokines in colorectal cancer patients using chemokine ELISA array. Immunohistochemistry was used to detect expression of CXCL5 in colorectal cancer patients tissues. Human HCT116 and SW480 cell lines stably transfected with CXCL5, shCXCL5 and shCXCR2 lentivirus plasmids were used in our in vitro study...
March 29, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28341702/nras-destines-tumor-cells-to-the-lungs
#20
Anastasios D Giannou, Antonia Marazioti, Nikolaos I Kanellakis, Ioanna Giopanou, Ioannis Lilis, Dimitra E Zazara, Giannoula Ntaliarda, Danai Kati, Vasileios Armenis, Georgia A Giotopoulou, Anthi C Krontira, Marina Lianou, Theodora Agalioti, Malamati Vreka, Maria Papageorgopoulou, Sotirios Fouzas, Dimitrios Kardamakis, Ioannis Psallidas, Magda Spella, Georgios T Stathopoulos
The lungs are frequently affected by cancer metastasis. Although NRAS mutations have been associated with metastatic potential, their exact role in lung homing is incompletely understood. We cross-examined the genotype of various tumor cells with their ability for automatic pulmonary dissemination, modulated NRAS expression using RNA interference and NRAS overexpression, identified NRAS signaling partners by microarray, and validated them using Cxcr1- and Cxcr2-deficient mice. Mouse models of spontaneous lung metastasis revealed that mutant or overexpressed NRAS promotes lung colonization by regulating interleukin-8-related chemokine expression, thereby initiating interactions between tumor cells, the pulmonary vasculature, and myeloid cells...
March 24, 2017: EMBO Molecular Medicine
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