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CXCR2

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https://www.readbyqxmd.com/read/28063617/corrigendum-to-lipocalin-2-mediates-non-alcoholic-steatohepatitis-by-promoting-neutrophil-macrophage-crosstalk-via-the-induction-of-cxcr2
#1
Dewei Ye, Kangmin Yang, Shufei Zang, Zhuofeng Lin, Hau-Tak Chau, Yudong Wang, Jialiang Zhang, Junping Shi, Aimin Xu, Shaoqiang Lin, Yu Wang
No abstract text is available yet for this article.
January 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28058861/downregulation-of-transgelin-blocks-interleukin-8-utilization-and-suppresses-vasculogenic-mimicry-in-breast-cancer-cells
#2
Anastasia R Aikins, MiJung Kim, Bernardo Raymundo, Chan-Wha Kim
Vasculogenic mimicry (VM) is a non-classical mechanism recently described in many tumors, whereby cancer cells, rather than endothelial cells, form blood vessels. Transgelin is an actin-binding protein that has been implicated in multiple stages of cancer development. In this study, we investigated the role of transgelin in VM and assessed its effect on the expression of endothelial and angiogenesis-related genes during VM in MDA-MB-231 breast cancer cells. We confirmed the ability of MDA-MB-231 cells to undergo VM through a tube formation assay...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28013312/mycobacteria-manipulate-g-protein-coupled-receptors-to-increase-mucosal-rac1-expression-in-the-lungs
#3
Nader Alaridah, Nataliya Lutay, Erik Tenland, Anna Rönnholm, Oskar Hallgren, Manoj Puthia, Gunilla Westergren-Thorsson, Gabriela Godaly
Mycobacterium bovis bacille Calmette-Guérin (BCG) is currently the only approved vaccine against tuberculosis (TB). BCG mimics M. tuberculosis (Mtb) in its persistence in the body and is used as a benchmark to compare new vaccine candidates. BCG was originally designed for mucosal vaccination, but comprehensive knowledge about its interaction with epithelium is currently lacking. We used primary airway epithelial cells (AECs) and a murine model to investigate the initial events of mucosal BCG interactions...
December 24, 2016: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28011398/glycosaminoglycans-are-important-mediators-of-neutrophilic-inflammation-in-vivo
#4
Martha Gschwandtner, Elisabeth Strutzmann, Mauro M Teixeira, Hans J Anders, Maria Diedrichs-Möhring, Tanja Gerlza, Gerhild Wildner, Remo C Russo, Tiziana Adage, Andreas J Kungl
The pro-inflammatory chemokine interleukin-8 (CXCL8) exerts its function by establishing a chemotactic gradient in infected or damaged tissues to guide neutrophil granulocytes to the site of inflammation via its G protein-coupled receptors (GPCRs) CXCR1 and CXCR2 located on neutrophils. Endothelial glycosaminoglycans (GAGs) have been proposed to support the chemotactic gradient formation and thus the inflammatory response by presenting the chemokine to approaching leukocytes. In this study, we show that neutrophil transmigration in vitro can be reduced by adding soluble GAGs and that this process is specific with respect to the nature of the glycan...
December 20, 2016: Cytokine
https://www.readbyqxmd.com/read/28000523/cxcr2-inhibition-in-pancreatic-cancer-opportunities-for-immunotherapy
#5
Jennifer P Morton, Owen J Sansom
No abstract text is available yet for this article.
January 2017: Immunotherapy
https://www.readbyqxmd.com/read/27999173/rac-signal-adaptation-controls-neutrophil-mobilization-from-the-bone-marrow
#6
Carlo Cosimo Campa, Giulia Germena, Elisa Ciraolo, Francesca Copperi, Anna Sapienza, Irene Franco, Alessandra Ghigo, Annalisa Camporeale, Augusta Di Savino, Miriam Martini, Alessia Perino, Remco T A Megens, Angela R M Kurz, Christoph Scheiermann, Markus Sperandio, Andrea Gamba, Emilio Hirsch
Mobilization of neutrophils from the bone marrow determines neutrophil blood counts and thus is medically important. Balanced neutrophil mobilization from the bone marrow depends on the retention-promoting chemokine CXCL12 and its receptor CXCR4 and the egression-promoting chemokine CXCL2 and its receptor CXCR2. Both pathways activate the small guanosine triphosphatase Rac, leaving the role of this signaling event in neutrophil retention and egression ambiguous. On the assumption that active Rac determines persistent directional cell migration, we generated a mathematical model to link chemokine-mediated Rac modulation to neutrophil egression time...
December 20, 2016: Science Signaling
https://www.readbyqxmd.com/read/27995997/tiarp-attenuates-autoantibody-mediated-arthritis-via-the-suppression-of-neutrophil-migration-by-reducing-cxcl2-cxcr2-and-il-6-expression
#7
Asuka Inoue, Isao Matsumoto, Yuki Tanaka, Naoto Umeda, Chinatsu Takai, Hoshimi Kawaguchi, Hiroshi Ebe, Hiroto Yoshida, Yoshihiro Matsumoto, Seiji Segawa, Satoru Takahashi, Takayuki Sumida
TNFα-induced adipose-related protein (TIARP) is a six-transmembrane protein expressed on macrophages, neutrophils and synoviocytes. We reported recently that mice deficient in TIARP (TIARP(-/-)) spontaneously develop arthritis and are highly susceptible to collagen-induced arthritis (CIA) with enhanced interleukin (IL)-6 production. However, the effects of TIARP on neutrophils and fibroblast-like synoviocytes (FLS) have not been elucidated. We analyzed the roles of TIARP in K/BxN serum transfer model using TIARP(-/-) mice...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974825/low-expression-of-cxcr1-2-on-neutrophils-predicts-poor-survival-in-patients-with-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#8
Ruonan Xu, Chunmei Bao, Huihuang Huang, Fang Lin, Yue Yuan, Siyu Wang, Lei Jin, Tao Yang, Ming Shi, Zheng Zhang, Fu-Sheng Wang
Polymorphonuclear neutrophils (PMNs) and proinflammatory cytokines have been implicated in the pathogenesis of acute-on-chronic liver failure (ACLF). But the utility of CXC chemokine receptor expression on PMNs as a biomarker for prediction of disease severity is still uncertain. In this study, we investigated the dynamic expression of CXCR1 and CXCR2 on neutrophils, and found that patients with hepatitis B virus-related ACLF displayed low expression of CXCR1 and CXCR2 on peripheral neutrophils compared with healthy subjects and patients with chronic hepatitis B...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27966653/the-accessory-proteins-reep5-and-reep6-refine-cxcr1-mediated-cellular-responses-and-lung-cancer-progression
#9
Cho Rong Park, Dong-Joo You, Sumi Park, Sunam Mander, Da-Eun Jang, Su-Cheong Yeom, Seong-Hyun Oh, Curie Ahn, Sang Heon Lee, Jae Young Seong, Jong-Ik Hwang
Some G-protein-coupled receptors have been reported to require accessory proteins with specificity for proper functional expression. In this study, we found that CXCR1 interacted with REEP5 and REEP6, but CXCR2 did not. Overexpression of REEP5 and REEP6 enhanced IL-8-stimulated cellular responses through CXCR1, whereas depletion of the proteins led to the downregulation of the responses. Although REEPs enhanced the expression of a subset of GPCRs, in the absence of REEP5 and REEP6, CXCR1 was expressed in the plasma membrane, but receptor internalization and intracellular clustering of β-arrestin2 following IL-8 treatment were impaired, suggesting that REEP5 and REEP6 might be involved in the ligand-stimulated endocytosis of CXCR1 rather than membrane expression, which resulted in strong cellular responses...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27965576/functional-genomics-identifies-tis21-dependent-mechanisms-and-putative-cancer-drug-targets-underlying-medulloblastoma-shh-type-development
#10
Giulia Gentile, Manuela Ceccarelli, Laura Micheli, Felice Tirone, Sebastiano Cavallaro
We have recently generated a novel medulloblastoma (MB) mouse model with activation of the Shh pathway and lacking the MB suppressor Tis21 (Patched1(+/-)/Tis21(KO) ). Its main phenotype is a defect of migration of the cerebellar granule precursor cells (GCPs). By genomic analysis of GCPs in vivo, we identified as drug target and major responsible of this defect the down-regulation of the promigratory chemokine Cxcl3. Consequently, the GCPs remain longer in the cerebellum proliferative area, and the MB frequency is enhanced...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27965453/staphylococcus-aureus-leukocidin-luked-and-hiv-1-gp120-target-different-sequence-determinants-on-ccr5
#11
Kayan Tam, Megan Schultz, Tamara Reyes-Robles, Bénédicte Vanwalscappel, Joshua Horton, Francis Alonzo, Beili Wu, Nathaniel R Landau, Victor J Torres
: Leukocidin ED (LukED) is a bicomponent pore-forming toxin produced by Staphylococcus aureus that lyses host cells by targeting the chemokine receptors CC chemokine receptor type 5 (CCR5), CXCR1, CXCR2, and DARC. In addition to its role as a receptor for LukED, CCR5 is the major coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and has been extensively studied. To compare how LukED and HIV-1 target CCR5, we analyzed their respective abilities to use CCR5/CCR2b chimeras to mediate cytotoxicity and virus entry...
December 13, 2016: MBio
https://www.readbyqxmd.com/read/27959418/cxcl7-promotes-proliferation-and-invasion-of-cholangiocarcinoma-cells
#12
Qian Guo, Zhixiang Jian, Baoqing Jia, Liang Chang
CXCL7 is an important chemoattractant cytokine, which signals through binding to its receptor CXCR2. Recent studies have demonstrated that the CXCL7/CXCR2 signaling plays a promoting role in several common malignancies, including lung, renal, colon, and breast cancer. However, the regulatory role of CXCL7, in cholangiocarcinoma, as well as the underlying mechanism, has not been previously reported. Herein, we found more positive expression of CXCL7 in cholangiocarcinoma tissues compared to adjacent non-tumor tissues...
December 12, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27958346/clinical-association-of-chemokine-c-x-c-motif-ligand-1-cxcl1-with-interstitial-pneumonia-with-autoimmune-features-ipaf
#13
Minrui Liang, Zhixing Jiang, Qiong Huang, Lei Liu, Yu Xue, Xiaoxia Zhu, Yiyun Yu, Weiguo Wan, Haihua Yang, Hejian Zou
The term "interstitial pneumonia with autoimmune features" (IPAF) has been recently proposed. We here investigate the clinical characteristics of IPAF and evaluate the clinical implications of CXCL1-CXCR2 axis in IPAF. An increased plasma level of CXCL1 was exhibited in IPAF compared to idiopathic interstitial pneumonia (IIP), chronic obstructive pulmonary disease (COPD), and healthy controls. Additionally, plasma CXCL1 levels were clinically associated with diffusing capacity of the lungs for carbon monoxide (DLCO), erythrocyte sedimentation rate (ESR), and involved parenchyma extension in IPAF...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27956697/epithelial-hypoxia-inducible-factor-2%C3%AE-facilitates-the-progression-of-colon-tumors-through-recruiting-neutrophils
#14
Daniel Triner, Xiang Xue, Andrew J Schwartz, Inkyung Jung, Justin A Colacino, Yatrik M Shah
Inflammation is a significant risk factor for colon cancer. Recent work has demonstrated essential roles for several infiltrating immune populations in the metaplastic progression following inflammation. Hypoxia and stabilization of hypoxia-inducible factors (HIFs) are hallmark features of inflammation and solid tumors. Previously, we demonstrated an important role for tumor epithelial HIF-2α in colon tumors, however, the function of epithelial HIF-2α as a critical link in the progression of inflammation to cancer has not been elucidated...
December 12, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27914596/characterization-of-inflammatory-markers-associated-with-systemic-lupus-erythematosus-patients-undergoing-treatment
#15
Rodolfo Pessato Timóteo, Douglas Cobo Micheli, Reginaldo Botelho Teodoro, Marlene Freire, Dernival Bertoncello, Eddie Fernando Candido Murta, Beatriz Martins Tavares-Murta
OBJECTIVE: To characterize the inflammatory profiles of patients with systemic lupus erythematosus receiving standard treatment compared to healthy controls. PATIENTS AND METHODS: Peripheral venous blood was collected from systemic lupus erythematosus patients (n=14) and controls (n=18) at enrollment. Blood samples were used for quantification, by flow cytometry, of CD11b (integrin) and Chemokine receptor CXCR2 expression surface antigen in neutrophils and lymphocytes, while cytokines were assayed in serum samples...
November 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27886237/lukmf-is-the-major-secreted-leukocidin-of-bovine-staphylococcus-aureus-and-is-produced-in-vivo-during-bovine-mastitis
#16
Manouk Vrieling, Eveline M Boerhout, Glenn F van Wigcheren, Kirsten J Koymans, Tanja G Mols-Vorstermans, Carla J C de Haas, Piet C Aerts, Ineke J J M Daemen, Kok P M van Kessel, Ad P Koets, Victor P M G Rutten, Piet J M Nuijten, Jos A G van Strijp, Lindert Benedictus
Staphylococcus aureus is a major human and animal pathogen and a common cause of mastitis in cattle. S. aureus secretes several leukocidins that target bovine neutrophils, crucial effector cells in the defence against bacterial pathogens. In this study, we investigated the role of staphylococcal leukocidins in the pathogenesis of bovine S. aureus disease. We show that LukAB, in contrast to the γ-hemolysins, LukED, and LukMF', was unable to kill bovine neutrophils, and identified CXCR2 as a bovine receptor for HlgAB and LukED...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27879294/cxcr2-is-involved-in-pulmonary-intravascular-macrophage-accumulation-and-angiogenesis-in-a-rat-model-of-hepatopulmonary-syndrome
#17
Xujiong Li, Yunxia Chen, Yongli Chang, Shufen Li, Zhongfu Zhao, Huiying Zhang
Hepatopulmonary syndrome (HPS) is a lung complication in various liver diseases, with high incidence, poor prognosis and no effective non-surgical treatments in patients with hepatocirrhosis. Therefore, assessing HPS pathogenesis to explore proper therapy strategies is clinically relevant. In the present study, male Sprague-Dawley rats underwent sham operation or common bile duct ligation (CBDL). Two weeks post-surgery, the following groups were set up for 2 weeks of treatment: sham + normal saline, CBDL + CXCR2 antagonist SB225002, CBDL + tumour necrosis factor α (TNF-α) antagonist PTX and CBDL + normal saline groups...
January 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27871915/inhibition-of-siglec-1-by-lentivirus-mediated-small-interfering-rna-attenuates-atherogenesis-in-apoe-deficient-mice
#18
Yi-Song Xiong, Ai-Lin Wu, Dong Mu, Juan Yu, Ping Zeng, Yi Sun, Jie Xiong
BACKGROUND: Siglec-1 is highly expressed on circulating monocytes and plaque macrophages in atherosclerotic patients, but the exact role of Siglec-1 in atherosclerosis has not been elucidated. METHODS: Lentiviral vector containing small interfering RNA targeting Siglec-1 (Lv-shSiglec-1) or control vector (Lv-shNC) were injected intravenously into 6-week old Apoe(-/-) mice. Then onset of atherosclerosis was observed. RESULTS: Siglec-1 was highly expressed in aortic plaques and it can be down-regulated by Lv-shSiglec-1 injection...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27826243/genetic-ablation-of-cxcr2-protects-against-cigarette-smoke-induced-lung-inflammation-and-injury
#19
Chad A Lerner, Wei Lei, Isaac K Sundar, Irfan Rahman
Antagonism of CXCR2 receptors, predominately located on neutrophils and critical for their immunomodulatory activity, is an attractive pharmacological therapeutic approach aimed at reducing the potentially damaging effects of heightened neutrophil influx into the lung. The role CXCR2 in lung inflammation in response to cigarette smoke (CS) inhalation using the mutant mouse approach is not known. We hypothesized that genetic ablation of CXCR2 would protect mice against CS-induced inflammation and DNA damage response...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27823622/main-pathways-of-action-of-brazilian-red-propolis-on-the-modulation-of-neutrophils-migration-in-the-inflammatory-process
#20
Bruno Bueno-Silva, Marcelo Franchin, Claudiney de Freitas Alves, Carina Denny, David Fernando Colón, Thiago Mattar Cunha, Severino Matias Alencar, Marcelo Henrique Napimoga, Pedro Luiz Rosalen
BACKGROUND: Brazilian propolis is popularly used as treatment for different diseases including the ones with inflammatory origin. Brazilian red propolis chemical profile and its anti-inflammatory properties were recently described however, its mechanism of action has not been investigated yet. AIM: Elucidate Brazilian red propolis major pathways of action on the modulation of neutrophil migration during the inflammatory process. METHODS: The ethanolic extract of propolis (EEP) activity was investigated for neutrophil migration into the peritoneal cavity, intravital microscopy (rolling and adhesion of leukocytes), quantification of cytokines TNF-α, IL-1β and chemokines CXCL1/KC, CXCL2/MIP-2, neutrophil chemotaxis induced by CXCL2/MIP-2, calcium influx and CXCR2 expression on neutrophils...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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