keyword
MENU ▼
Read by QxMD icon Read
search

CXCR2

keyword
https://www.readbyqxmd.com/read/27914596/characterization-of-inflammatory-markers-associated-with-systemic-lupus-erythematosus-patients-undergoing-treatment
#1
Rodolfo Pessato Timóteo, Douglas Cobo Micheli, Reginaldo Botelho Teodoro, Marlene Freire, Dernival Bertoncello, Eddie Fernando Candido Murta, Beatriz Martins Tavares-Murta
OBJECTIVE: To characterize the inflammatory profiles of patients with systemic lupus erythematosus receiving standard treatment compared to healthy controls. PATIENTS AND METHODS: Peripheral venous blood was collected from systemic lupus erythematosus patients (n=14) and controls (n=18) at enrollment. Blood samples were used for quantification, by flow cytometry, of CD11b (integrin) and Chemokine receptor CXCR2 expression surface antigen in neutrophils and lymphocytes, while cytokines were assayed in serum samples...
November 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27886237/lukmf-is-the-major-secreted-leukocidin-of-bovine-staphylococcus-aureus-and-is-produced-in-vivo-during-bovine-mastitis
#2
Manouk Vrieling, Eveline M Boerhout, Glenn F van Wigcheren, Kirsten J Koymans, Tanja G Mols-Vorstermans, Carla J C de Haas, Piet C Aerts, Ineke J J M Daemen, Kok P M van Kessel, Ad P Koets, Victor P M G Rutten, Piet J M Nuijten, Jos A G van Strijp, Lindert Benedictus
Staphylococcus aureus is a major human and animal pathogen and a common cause of mastitis in cattle. S. aureus secretes several leukocidins that target bovine neutrophils, crucial effector cells in the defence against bacterial pathogens. In this study, we investigated the role of staphylococcal leukocidins in the pathogenesis of bovine S. aureus disease. We show that LukAB, in contrast to the γ-hemolysins, LukED, and LukMF', was unable to kill bovine neutrophils, and identified CXCR2 as a bovine receptor for HlgAB and LukED...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27879294/cxcr2-is-involved-in-pulmonary-intravascular-macrophage-accumulation-and-angiogenesis-in-a-rat-model-of-hepatopulmonary-syndrome
#3
Xujiong Li, Yunxia Chen, Yongli Chang, Shufen Li, Zhongfu Zhao, HuiYing Zhang
Hepatopulmonary syndrome (HPS) is a lung complication in various liver diseases, with high incidence, poor prognosis and no effective non-surgical treatments in patients with hepatocirrhosis. Therefore, assessing HPS pathogenesis to explore proper therapy strategies is clinically relevant. In this study, male Sprague-Dawley rats underwent sham operation or common bile duct ligation (CBDL). Two weeks post-surgery, the following groups were setup for 2 weeks of treatment: Sham + normal saline, CBDL + CXCR2 antagonist SB225002, CBDL + TNF-α antagonist PTX, and CBDL + normal saline groups...
November 22, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27871915/inhibition-of-siglec-1-by-lentivirus-mediated-small-interfering-rna-attenuates-atherogenesis-in-apoe-deficient-mice
#4
Yi-Song Xiong, Ai-Lin Wu, Dong Mu, Juan Yu, Ping Zeng, Yi Sun, Jie Xiong
BACKGROUND: Siglec-1 is highly expressed on circulating monocytes and plaque macrophages in atherosclerotic patients, but the exact role of Siglec-1 in atherosclerosis has not been elucidated. METHODS: Lentiviral vector containing small interfering RNA targeting Siglec-1 (Lv-shSiglec-1) or control vector (Lv-shNC) were injected intravenously into 6-week old Apoe(-/-) mice. Then onset of atherosclerosis was observed. RESULTS: Siglec-1 was highly expressed in aortic plaques and it can be down-regulated by Lv-shSiglec-1 injection...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27826243/genetic-ablation-of-cxcr2-protects-against-cigarette-smoke-induced-lung-inflammation-and-injury
#5
Chad A Lerner, Wei Lei, Isaac K Sundar, Irfan Rahman
Antagonism of CXCR2 receptors, predominately located on neutrophils and critical for their immunomodulatory activity, is an attractive pharmacological therapeutic approach aimed at reducing the potentially damaging effects of heightened neutrophil influx into the lung. The role CXCR2 in lung inflammation in response to cigarette smoke (CS) inhalation using the mutant mouse approach is not known. We hypothesized that genetic ablation of CXCR2 would protect mice against CS-induced inflammation and DNA damage response...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27823622/main-pathways-of-action-of-brazilian-red-propolis-on-the-modulation-of-neutrophils-migration-in-the-inflammatory-process
#6
Bruno Bueno-Silva, Marcelo Franchin, Claudiney de Freitas Alves, Carina Denny, David Fernando Colón, Thiago Mattar Cunha, Severino Matias Alencar, Marcelo Henrique Napimoga, Pedro Luiz Rosalen
BACKGROUND: Brazilian propolis is popularly used as treatment for different diseases including the ones with inflammatory origin. Brazilian red propolis chemical profile and its anti-inflammatory properties were recently described however, its mechanism of action has not been investigated yet. AIM: Elucidate Brazilian red propolis major pathways of action on the modulation of neutrophil migration during the inflammatory process. METHODS: The ethanolic extract of propolis (EEP) activity was investigated for neutrophil migration into the peritoneal cavity, intravital microscopy (rolling and adhesion of leukocytes), quantification of cytokines TNF-α, IL-1β and chemokines CXCL1/KC, CXCL2/MIP-2, neutrophil chemotaxis induced by CXCL2/MIP-2, calcium influx and CXCR2 expression on neutrophils...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27820602/an-interferon-%C3%AE-resistant-and-nlrp3-inflammasome-independent-subtype-of-eae-with-neuronal-damage
#7
Makoto Inoue, Po-Han Chen, Stephen Siecinski, Qi-Jing Li, Chunlei Liu, Lawrence Steinman, Simon G Gregory, Eric Benner, Mari L Shinohara
Inflammation induced by innate immunity influences the development of T cell-mediated autoimmunity in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). We found that strong activation of innate immunity induced Nod-like receptor protein 3 (NLRP3) inflammasome-independent and interferon-β (IFNβ)-resistant EAE (termed type B EAE), whereas EAE induced by weak activation of innate immunity requires the NLRP3 inflammasome and is sensitive to IFNβ treatment. Instead, an alternative inflammatory mechanism, including membrane-bound lymphotoxin-β receptor (LTβR) and CXC chemokine receptor 2 (CXCR2), is involved in type B EAE development, and type B EAE is ameliorated by antagonizing these receptors...
November 7, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27815178/the-inflammatory-chemokine-cxcl18b-exerts-neutrophil-specific-chemotaxis-via-the-promiscuous-chemokine-receptor-cxcr2-in-zebrafish
#8
Vincenzo Torraca, Natasja A Otto, Aidin Tavakoli-Tameh, Annemarie H Meijer
Cxcl18b is a chemokine found in zebrafish and in other piscine and amphibian species. Cxcl18b is a reliable inflammatory marker; however, its function is yet to be elucidated. Here, we found that Cxcl18b is chemotactic towards neutrophils, similarly to Cxcl8a/Interleukin-8, the best characterised neutrophil chemoattractant in humans and teleosts. Like Cxcl8a, Cxcl18b-dependent recruitment required the chemokine receptor Cxcr2, while it was unaffected by depletion of the other two neutrophil receptors cxcr1 and cxcr4b...
February 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27807540/mir-940-suppresses-tumor-cell-invasion-and-migration-via-regulation-of-cxcr2-in-hepatocellular-carcinoma
#9
Dong Ding, Yaodong Zhang, Renjie Yang, Xing Wang, Guwei Ji, Liqun Huo, Zicheng Shao, Xiangcheng Li
Aim. To investigate the expression of miR-940 in the hepatocellular carcinoma (HCC) and its impact on function and biological mechanism in the HCC cells. Methods. Quantitative RT-PCR analysis was used to quantify miR-940 expression in 46 cases of tissues and cells. Transfection of HCC cell lines was performed by miR-940 mimics; the abilities of invasion and migration were assessed through Transwell array. Western blot represents the alteration in expression of CXCR2 by miR-940 mimics. Results. miR-940 expression was decreased significantly in the HCC tissues and the relevant cell lines...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27807194/therapeutic-targeting-of-the-g-csf-receptor-reduces-neutrophil-trafficking-and-joint-inflammation-in-antibody-mediated-inflammatory-arthritis
#10
Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Gabrielle L Goldberg, Nicholas J Wilson, Karen Scalzo-Inguanti, Charley Mackenzie-Kludas, Kate E Lawlor, Ian P Wicks, Lorena E Brown, Adriana Baz Morelli, Con Panousis, Michael J Wilson, Andrew D Nash, Brent S McKenzie, Arna E Andrews
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. G-CSF- and G-CSF receptor-deficient mice are profoundly protected in several models of rheumatoid arthritis, and Ab blockade of G-CSF also protects against disease. To further investigate the actions of blocking G-CSF/G-CSF receptor signaling in inflammatory disease, and as a prelude to human studies of the same approach, we developed a neutralizing mAb to the murine G-CSF receptor, which potently antagonizes binding of murine G-CSF and thereby inhibits STAT3 phosphorylation and G-CSF receptor signaling...
November 2, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27802348/major-neutrophilia-observed-in-acute-phase-of-human-leptospirosis-is-not-associated-with-increased-expression-of-granulocyte-cell-activation-markers
#11
Loic Raffray, Claude Giry, David Vandroux, Barbara Kuli, Andry Randrianjohany, Anne-Marie Pequin, Frédéric Renou, Marie-Christine Jaffar-Bandjee, Philippe Gasque
It has long been known that pathogenic Leptospira can mobilize the immune system but the specific contribution of neutrophils to control the infectious challenge remains to be clarified. We herein analyzed the phenotype of circulating neutrophils of patients with leptospirosis and healthy controls for the expression of toll-like receptor (TLR) type 2 (TLR2, to sense the leptospiral LPS) and several activation markers: interleukin 8 chemokine receptor CD182 (CXCR2), CD11b of the integrin/opsonin complement receptor type 3 (CR3) and CD15 (ligand of the selectin)...
2016: PloS One
https://www.readbyqxmd.com/read/27799249/myeloid-derived-suppressor-cell-subset-accumulation-in-renal-cell-carcinoma-parenchyma-is-associated-with-intratumoral-expression-of-il-1%C3%AE-il-8-cxcl5-and-mip-1%C3%AE
#12
Yana G Najjar, Patricia A Rayman, Xuefei Jia, Paul G Pavicic, Brian I Rini, Charles S Tannenbaum, Jennifer Ko, Samuel Haywood, Peter A Cohen, Thomas Hamilton, Claudia M Diaz Montero, James H Finke
PURPOSE: Little is known about the association between MDSC subsets and various chemokines in patients with RCC, or the factors that draw MDSC into tumor parenchyma. EXPERIMENTAL DESIGN: We analyzed PMN-MDSC, M-MDSC and I-MDSC from the parenchyma and peripheral blood of 48 RCC patients, isolated at nephrectomy. We analyzed levels of IL-1β, IL-8, CXCL5, Mip-1α, MCP-1 and Rantes. Furthermore, we performed experiments in a Renca murine model to assess therapeutic synergy between CXCL2 and anti-PD1, and to elucidate the impact of IL-1β blockade on MDSC...
October 31, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27768123/milk-fat-globule-egf-factor-8-suppresses-the-aberrant-immune-response-of-systemic-lupus-erythematosus-derived-neutrophils-and-associated-tissue-damage
#13
Wei Huang, Jiyuan Wu, Huiqin Yang, Yin Xiong, Rui Jiang, Tianpen Cui, Duyun Ye
Abnormal features of the systemic lupus erythematosus (SLE)-derived neutrophils, promoted aberrant immune response, have inspired new studies of the induction of autoimmunity and the development of organ damage in SLE. In this study, we explore the effect of milk fat globule-EGF factor 8 (MFG-E8) on the aberrant nitrification features in pristane-induced lupus. SLE patients and mice with pristane-induced lupus develop autoantibodies associated with MFG-E8 overproduction. However, the deletion of MFG-E8 leads to uncontrolled early pulmonary and peritoneal inflammation and tissue damage in mice with pristane-induced lupus...
October 21, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27748886/cxcl5-promotes-the-proliferation-and-migration-of-glioma-cells-in-autocrine-and-paracrine-dependent-manners
#14
Zhijie Dai, Jun Wu, Fenghua Chen, Quan Cheng, Mingyu Zhang, Ying Wang, Yong Guo, Tao Song
CXCL5 and its receptor CXCR2 have been found to be involved in tumorigenesis and cancer progression. Recent studies have shown that CXCR2 is upregulated in glioma tissues, and associated with poor prognosis and recurrence. However, the role of CXCL5/CXCR2 signaling in mediating the malignant phenotypes of glioma cells, as well as the underlying mechanism, still remains unclear. In the present study, we found that CXCL5 was upregulated in glioma tissues compared to that noted in normal brain tissues. High CXCL5 levels were significantly associated with higher tumor grade, advanced clinical stage, and shorter survival time of glioma patients...
October 10, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27742769/the-chemokine-cxcr2-antagonist-azd5069-preserves-neutrophil-mediated-host-immunity-in-non-human-primates
#15
Mohib Uddin, Catherine Betts, Ian Robinson, Anna Malmgren, Charles Humfrey
No abstract text is available yet for this article.
October 14, 2016: Haematologica
https://www.readbyqxmd.com/read/27742059/cxcl1-chemokine-c-x-c-motif-receptor-2-signaling-stimulates-the-recruitment-of-bone-marrow-derived-mesenchymal-cells-into-diffuse-type-gastric-cancer-stroma
#16
Hiroaki Kasashima, Masakazu Yashiro, Hirohisa Nakamae, Kisyu Kitayama, Go Masuda, Haruhito Kinoshita, Tatsunari Fukuoka, Tsuyoshi Hasegawa, Takahiko Nakane, Masayuki Hino, Kosei Hirakawa, Masaichi Ohira
Tumor stromal cells play a critical role in the progression of diffuse-type gastric cancer (DGC). The aim of this study was to clarify where tumor stromal cells originate from and which factor(s) recruits them into the tumor stroma. Immunodeficient mice with bone marrow transplantation from the cytomegalovirus enhancer/chicken β-actin promoter-enhanced green fluorescent protein mice were used for the in vivo experiments. An in vitro study analyzed the chemotaxis-stimulating factor from DGC cells using bone marrow-derived mesenchymal cells (BM-MCs)...
October 8, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27737879/cxcr2-dependent-accumulation-of-tumor-associated-neutrophils-regulates-t-cell-immunity-in-pancreatic-ductal-adenocarcinoma
#17
Timothy Chao, Emma E Furth, Robert H Vonderheide
Tumor-associated neutrophils are increasingly recognized for their ability to promote tumor progression, mediate resistance to therapy, and regulate immunosuppression. Evidence from various murine models has shown that the chemokine receptor CXCR2 attracts neutrophil into tumors and, therefore, represents a tractable therapeutic target. Here, we report prominent expression of a neutrophil gene signature in a subset of human pancreatic adenocarcinoma (PDA). CXCL5 was the most prominently expressed CXCR2 ligand in human PDA, and its expression was higher in PDA than in any other common tumor represented in The Cancer Genome Atlas...
November 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27727017/defocused-low-energy-shock-wave-activates-adipose-tissue-derived-stem-cells-in-vitro-via-multiple-signaling-pathways
#18
Lina Xu, Yong Zhao, Muwen Wang, Wei Song, Bo Li, Wei Liu, Xunbo Jin, Haiyang Zhang
BACKGROUND AIMS: We found defocused low-energy shock wave (DLSW) could be applied in regenerative medicine by activating mesenchymal stromal cells. However, the possible signaling pathways that participated in this process remain unknown. In the present study, DLSW was applied in cultured rat adipose tissue-derived stem cells (ADSCs) to explore its effect on ADSCs and the activated signaling pathways. METHODS: After treating with DLSW, the cellular morphology and cytoskeleton of ADSCs were observed...
October 7, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27723802/nf-%C3%AE%C2%BAb-mediated-ccl20-reigns-dominantly-in-cxcr2-driven-ovarian-cancer-progression
#19
Rosa Mistica C Ignacio, Syeda M Kabir, Eun-Sook Lee, Samuel E Adunyah, Deok-Soo Son
Ovarian cancer is an inflammation-associated malignancy with a high mortality rate. CXCR2 expressing ovarian cancers are aggressive with poorer outcomes. We previously demonstrated that CXCR2-driven ovarian cancer progression potentiated NF-κB activation through EGFR-transactivated Akt. Here, we identified the chemokine signature involved in CXCR2-driven ovarian cancer progression using a mouse peritoneal xenograft model for ovarian cancer spreading with CXCR2-negative (SKA) and positive (SKCXCR2) cells generated previously from parental SKOV-3 cells...
2016: PloS One
https://www.readbyqxmd.com/read/27721403/cxcl2-mif-cxcr2-signaling-promotes-the-recruitment-of-myeloid-derived-suppressor-cells-and-is-correlated-with-prognosis-in-bladder-cancer
#20
H Zhang, Y-L Ye, M-X Li, S-B Ye, W-R Huang, T-T Cai, J He, J-Y Peng, T-H Duan, J Cui, X-S Zhang, F-J Zhou, R-F Wang, J Li
The accumulation of myeloid-derived suppressor cells (MDSCs) has been observed in solid tumors and is correlated with tumor progression; however, the underlying mechanism is still poorly understood. In this study, we identified a mechanism by which tumor cells induce MDSC accumulation and expansion in the bladder cancer (BC) microenvironment via CXCL2/MIF-CXCR2 signaling. Elevated expression of CXCL2 and MIF and an increased number of CD33(+) MDSCs were detected in BC tissues, and these increases were significantly associated with advanced disease stage and poor patient prognosis (P<0...
October 10, 2016: Oncogene
keyword
keyword
22435
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"