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CXCR2

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https://www.readbyqxmd.com/read/29344240/cxcl5-as-an-autocrine-or-paracrine-cytokine-is-associated-with-proliferation-and-migration-of-hepatoblastoma-hepg2-cells
#1
Yang Yang, Jie Hou, Mingliang Shao, Wei Zhang, Yaling Qi, Shengnan E, Shuqiu Wang, Hongyu Sui, Dexin Meng, Baixin Wang, Mingfu Wang, Yang Han, Yu Cao, Xiaoqing Huang, Yue Li, Pengxia Zhang, Weiqun Wang
C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. Increasing evidence has indicated that CXCL5 is involved in the tumorigenesis of various malignancies. The present investigation demonstrated that CXCL5 was expressed in both hepatoblastoma HepG2 cells and liver stellate LX-2 cells, and CXCL5's receptor C-X-C chemokine receptor type 2 (CXCR2) was expressed in HepG2 cells by reverse transcription-polymerase chain reaction (RT-PCR), western blotting and ELISA assays...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29338773/chemokine-ligand-receptor-interactions-critically-regulate-cutaneous-wound-healing
#2
Erich Bünemann, Norman-Philipp Hoff, Bettina Alexandra Buhren, Ulrike Wiesner, Stephan Meller, Edwin Bölke, Anja Müller-Homey, Robert Kubitza, Thomas Ruzicka, Albert Zlotnik, Bernhard Homey, Peter Arne Gerber
BACKGROUND: Wound healing represents a dynamic process involving directional migration of different cell types. Chemokines, a family of chemoattractive proteins, have been suggested to be key players in cell-to-cell communication and essential for directed migration of structural cells. Today, the role of the chemokine network in cutaneous wound healing is not fully understood. Unraveling the chemokine-driven communication pathways in this complex process could possibly lead to new therapeutic strategies in wound healing disorders...
January 16, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29332242/selective-ikk2-inhibitor-imd0354-disrupts-nf-%C3%AE%C2%BAb-signaling-to-suppress-corneal-inflammation-and-angiogenesis
#3
Anton Lennikov, Pierfrancesco Mirabelli, Anthony Mukwaya, Mira Schaupper, Muthukumar Thangavelu, Mieszko Lachota, Zaheer Ali, Lasse Jensen, Neil Lagali
Corneal neovascularization is a sight-threatening condition caused by angiogenesis in the normally avascular cornea. Neovascularization of the cornea is often associated with an inflammatory response, thus targeting VEGF-A alone yields only a limited efficacy. The NF-κB signaling pathway plays important roles in inflammation and angiogenesis. Here, we study consequences of the inhibition of NF-κB activation through selective blockade of the IKK complex IκB kinase β (IKK2) using the compound IMD0354, focusing on the effects of inflammation and pathological angiogenesis in the cornea...
January 13, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29312644/systematic-review-and-meta-analysis-of-the-prognostic-value-of-cxcr2-in-solid-tumor-patients
#4
Yong Yang, Baoyang Luo, Yong An, Han Sun, Huihua Cai, Donglin Sun
CXC chemokine receptor-2 (CXCR2) expression is associated with the prognosis of multiple cancers. We performed a meta-analysis to determine the association between the CXCR2 expression in tumor tissue and patient prognosis. We compiled related literature from PubMed, Embase, and Web of Science (last updated July 31, 2017). A total of 4012 patients with solid tumors from 21 studies were included to evaluate the association between CXCR2 and overall survival, recurrence-free survival, or disease-free survival...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29309879/anti-nociceptive-role-of-cxcl1-in-a-murine-model-of-peripheral-nerve-injury-induced-neuropathic-pain
#5
Ling Cao, Jennifer T Malon
Both spinal cord infiltrating CD4+ T lymphocytes and microglial CD40 contribute to the maintenance of neuropathic pain-like behaviors induced by spinal nerve L5 transection (L5Tx), a murine model of neuropathic pain. Here, we sought to investigate the involvement of multiple chemokines in microglial CD40-mediated and CD4+ T lymphocytes-mediated L5Tx-induced sensory hypersensitivity. Spinal cord chemokine expression in CD4 knockout (KO), CD40 KO, and wild type (WT) BALB/c mice was determined at the protein level via multiplex assays and at the RNA level via quantitative real-time PCR...
January 5, 2018: Neuroscience
https://www.readbyqxmd.com/read/29290145/glycosaminoglycan-interactions-fine-tune-chemokine-mediated-neutrophil-trafficking-structural-insights-and-molecular-mechanisms
#6
Krishna Rajarathnam, Krishna Mohan Sepuru, Prem Raj B Joseph, Kirti V Sawant, Aaron J Brown
Circulating neutrophils, rapidly recruited in response to microbial infection, form the first line in host defense. Humans express ~50 chemokines, of which a subset of seven chemokines, characterized by the conserved "Glu-Leu-Arg" motif, mediate neutrophil recruitment. Neutrophil-activating chemokines (NACs) share similar structures, exist as monomers and dimers, activate the CXCR2 receptor on neutrophils, and interact with tissue glycosaminoglycans (GAGs). Considering cellular assays have shown that NACs have similar CXCR2 activity, the question has been and remains, why do humans express so many NACs? In this review, we make the case that NACs are not redundant and that distinct GAG interactions determine chemokine-specific in vivo functions...
November 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29288512/pretreatment-of-probiotic-bifico-ameliorates-colitis-associated-cancer-in-mice-transcriptome-and-gut-flora-profiling
#7
Huan Song, Weiyi Wang, Bo Shen, Hao Jia, Zhaoyuan Hou, Ping Chen, Yunwei Sun
Individuals with inflammatory bowel disease (IBD) are at a high risk for developing colitis-associated cancer (CAC). Strategies to block the process from IBD to CAC should be considered. In the experiment, we aim to explore the chemopreventive efficacy of the probiotic cocktail Bifico and its potential mechanism in azoxymethane (AOM) and dextran sodium sulphate (DSS) induced colitis-associated cancer in mice. Oral pretreatment of Bifico was adopted to evaluate its protective effect. The colorectums of thirty-five C57BL/6 mice were collected and examined for degree of inflammation and tumorigenesis...
December 30, 2017: Cancer Science
https://www.readbyqxmd.com/read/29285315/cxcl8-derived-from-tumor-associated-macrophages-and-esophageal-squamous-cell-carcinomas-contributes-to-tumor-progression-by-promoting-migration-and-invasion-of-cancer-cells
#8
Masayoshi Hosono, Yu-Ichiro Koma, Nobuhisa Takase, Naoki Urakawa, Nobuhide Higashino, Kazuki Suemune, Himiko Kodaira, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Tumor-associated macrophages (TAMs) are involved in tumor progression and poor prognosis in several malignancies. We previously demonstrated the interaction between high numbers of infiltrating TAMs and poor prognosis in esophageal squamous cell carcinomas (ESCCs). To investigate the significance of TAMs in ESCC, we conducted a cDNA microarray analysis of peripheral blood monocytes (PBMo)-derived macrophages and PBMo-derived macrophages stimulated with conditioned media of TE-series ESCC cell lines (TAM-like PBMo-derived macrophages)...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29276973/molecular-and-functional-characterization-of-tumor-induced-factor-tif-hamster-homolog-of-cxcl3-gro%C3%AE-displays-tumor-suppressive-activity
#9
Lili Jin, Zhou-Fang Li, Da-Kui Wang, Meina Sun, Wei Qi, Qiang Ma, Li Zhang, Chun Chu, Elaine Y M Chan, Susanna S T Lee, Helen Wise, Ka-Fai To, Ying Shi, Naiming Zhou, Wing-Tai Cheung
Previously our lab has created a mouse ovarian xenograft model of copy number variation (CNV)-mediated G protein-coupled receptor (GPCR) MAS-driven tumorigenesis, and RNA profiling identified a putative chemokine tumor-induced factor (Tif). Sequence analysis and chemotactic study suggested that Tif was likely to be a hamster homolog of human GROγ (CXCL3) [IJC 125 (2009): 1316-1327]. In the present study, we report the molecular and functional characterization of the Tif gene. Genomic study of CHO-K1 cells indicated that Tif gene consisted of 4 exons, characterized with an antisense B1 element which is embedded in the fourth exon...
December 22, 2017: Cytokine
https://www.readbyqxmd.com/read/29229683/mesenchymal-stem-cells-promote-endothelial-progenitor-cell-migration-vascularization-and-bone-repair-in-tissue-engineered-constructs-via-activating-cxcr2-src-pkl-vav2-rac1
#10
Zhilin Li, Aijun Yang, Xiaolong Yin, Shiwu Dong, Fei Luo, Ce Dou, Xu Lan, Zhao Xie, Tianyong Hou, Jianzhong Xu, Junchao Xing
Tissue-engineered constructs (TECs) hold great promise for treating large bone defects. Incorporated mesenchymal stem cells (MSCs) can facilitate the vascularization of TECs. Nevertheless, the underlying mechanism remains ambiguous. Here we analyzed the roles of C-X-C chemokine receptor 2 (CXCR2) and its downstream signal pathways in MSC-induced endothelial progenitor cell (EPC) migration. Transwell assays and immunofluorescence staining were performed for cell migration analysis in vitro and in vivo, respectively...
December 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29224778/rapid-mobilization-reveals-a-highly-engraftable-hematopoietic-stem-cell
#11
Jonathan Hoggatt, Pratibha Singh, Tiffany A Tate, Bin-Kuan Chou, Shruti R Datari, Seiji Fukuda, Liqiong Liu, Peter V Kharchenko, Amir Schajnovitz, Ninib Baryawno, Francois E Mercier, Joseph Boyer, Jason Gardner, Dwight M Morrow, David T Scadden, Louis M Pelus
Hematopoietic stem cell transplantation is a potential curative therapy for malignant and nonmalignant diseases. Improving the efficiency of stem cell collection and the quality of the cells acquired can broaden the donor pool and improve patient outcomes. We developed a rapid stem cell mobilization regimen utilizing a unique CXCR2 agonist, GROβ, and the CXCR4 antagonist AMD3100. A single injection of both agents resulted in stem cell mobilization peaking within 15 min that was equivalent in magnitude to a standard multi-day regimen of granulocyte colony-stimulating factor (G-CSF)...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29207576/glycosaminoglycan-mediated-downstream-signaling-of-cxcl8-binding-to-endothelial-cells
#12
Rupert Derler, Bernd Gesslbauer, Corinna Weber, Elisabeth Strutzmann, Ingrid Miller, Andreas Kungl
The recruitment of leukocytes, mediated by endothelium bound chemokine gradients, is a vital process in inflammation. The highly negatively charged, unbranched polysaccharide family of glycosaminoglycans (GAGs), such as heparan sulfate and chondroitin sulfate mediate chemokine immobilization. Specifically the binding of CXCL8 (interleukin 8) to GAGs on endothelial cell surfaces is known to regulate neutrophil recruitment. Currently, it is not clear if binding of CXCL8 to GAGs leads to endothelial downstream signaling in addition to the typical CXCR1/CXCR2 (C-X-C motif chemokine receptor 1 and 2)-mediated signaling which activates neutrophils...
December 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29200871/the-clinical-significance-of-cxcl5-in-non-small-cell-lung-cancer
#13
Kongju Wu, Shengnan Yu, Qian Liu, Xianguang Bai, Xinhua Zheng, Kongming Wu
As a CXC-type chemokine, ENA78/CXCL5 is an important attractant for granulocytes by binding to its receptor CXCR2. Recent studies proved that CXCL5/CXCR2 axis plays an oncogenic role in many human cancers. However, the exact clinical significance of CXCL5 in lung cancer has not been well defined. Here, we found that the serum protein expression of CXCL5 was significantly increased in non-small cell lung cancer (NSCLC) compared with that in healthy volunteers. Immunohistochemistry staining revealed that CXCL5 protein was higher in various lung cancer tissues compared with normal tissues...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29197248/the-role-of-il-8-cxcr2-signaling-in-microcystin-lr-triggered-endothelial-cell-activation-and-increased-vascular-permeability
#14
Limei Chen, Xiaoying Liu, Zhifang Pan, Shunmei Liu, Huirong Han, Chunling Zhao, Xuexi Tang
Microcystins are a family of cyclic heptapeptide toxins naturally produced by freshwater cyanobacteria. Microcystin-LR (MCLR) is believed to be the most toxic and common one with various pathological effects on human and mammals. However, the effects of MCLR on endothelial cells and vascular homeostasis have been largely unknown. We explored the mRNA and protein expression changes of several pro-inflammatory mediators in human umbilical vein endothelial cells (HUVECs) and C57BC/6 mice exposed to MCLR. Tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), especially interleukin-8 (IL-8) were remarkably upregulated both in endothelial cells and in serum...
November 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/29196437/targeting-both-tumour-associated-cxcr2-neutrophils-and-ccr2-macrophages-disrupts-myeloid-recruitment-and-improves-chemotherapeutic-responses-in-pancreatic-ductal-adenocarcinoma
#15
Timothy M Nywening, Brian A Belt, Darren R Cullinan, Roheena Z Panni, Booyeon J Han, Dominic E Sanford, Ryan C Jacobs, Jian Ye, Ankit A Patel, William E Gillanders, Ryan C Fields, David G DeNardo, William G Hawkins, Peter Goedegebuure, David C Linehan
OBJECTIVE: Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive tumour microenvironment (TME). Targeting tumour-associated CXCR2+neutrophils (TAN) or tumour-associated CCR2+ macrophages (TAM) alone improves antitumour immunity in preclinical models. However, a compensatory influx of an alternative myeloid subset may result in a persistent immunosuppressive TME and promote therapeutic resistance...
December 1, 2017: Gut
https://www.readbyqxmd.com/read/29179487/parp-1-promotes-tumor-recurrence-after-warm-ischemic-liver-graft-transplantation-via-neutrophil-recruitment-and-polarization
#16
Shuai Wang, Fa-Ji Yang, Xun Wang, Yuan Zhou, Bo Dai, Bing Han, Hu-Cheng Ma, Yi-Tao Ding, Xiao-Lei Shi
Poly (ADP-ribose) polymerase 1 (PARP-1) is a crucial contributor to exacerbate ischemia and reperfusion (IR) injury and cancer process. However, there is little research into whether PARP-1 affects the hepatocellular carcinoma (HCC) recurrence after liver transplantation. In this study, we investigated the influence of PARP-1 on hepatic neutrophil mobilizing and phenotype shifting which may lead to HCC recurrence after liver transplantation. We found that rats received the grafts with warm ischemic injury had higher risk of HCC recurrence, which was markedly prevented by pharmacological inhibition of PARP-1 after liver transplantation...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29169181/inflammatory-cytokine-il-8-cxcl8-promotes-tumour-escape-from-hepatocyte-induced-dormancy
#17
Ahmad S Khazali, Amanda M Clark, Alan Wells
BACKGROUND: Breast cancers can recur after a long latency period following 'successful' primary treatments. Chronic inflammation significantly correlates with reduced diseased-free survival in breast cancer patients and could be a point of intervention to prevent recurrence. Liver is among the main sites of breast cancer recurrence. Thus, we hypothesise that inflammatory signals from hepatic stellate cells, the major inflammatory regulators in the sinusoid, could stimulate dormant cancer cells to emerge...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29168180/cxcr2-is-critical-for-bacterial-control-and-development-of-joint-damage-and-pain-in-staphylococcus-aureus-induced-septic-arthritis-in-mouse
#18
Daiane Boff, Vivian L S Oliveira, Celso M Queiroz Junior, Tarcília A Silva, Marcelo Allegretti, Waldiceu A Verri, Paul Proost, Mauro M Teixeira, Flavio A Amaral
Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrophils have an important function in controlling bacterial burden. This work aimed to study the role of CXCR2 in the control of infection, hypernociception and tissue damage in S. aureus-induced septic arthritis in mice...
November 22, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29167025/decrease-of-galectin-3-in-keratinocytes-a-potential-diagnostic-marker-and-a-critical-contributor-to-the-pathogenesis-of-psoriasis
#19
Zhen-Rui Shi, Guo-Zhen Tan, Cui-Xiang Cao, Yan-Fang Han, Zhen Meng, Xiao-Yong Man, Ze-Xin Jiang, Yu-Ping Zhang, Ning-Ning Dang, Kai-Hua Wei, Ding-Fang Bu, Fu-Tong Liu, Liangchun Wang
Psoriasis-specific proteins dysregulated in keratinocytes and involved in the pathophysiological process of psoriasis remains elusive. We report here that epidermal galectin-3 expression is significantly downregulated in lesional skin, but not in non-lesional skin in psoriasis patients, nor in a group of diseases known as psoriasiform dermatitis clinically and histologically similar to psoriasis. The deficiency of epidermal galectin-3 is sufficient to promote development of psoriatic lesions, as evidenced by more severe skin inflammation in galectin-3 knockout (gal3(-/-)) mice, compared to wild-type mice, after imiquimod treatment, and in skin from gal3(-/-) mice grafted onto wildtype mice...
November 20, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29163477/genes-critical-for-developing-periodontitis-lessons-from-mouse-models
#20
REVIEW
Teun J de Vries, Stefano Andreotta, Bruno G Loos, Elena A Nicu
Since the etiology of periodontitis in humans is not fully understood, genetic mouse models may pinpoint indispensable genes for optimal immunological protection of the periodontium against tissue destruction. This review describes the current knowledge of genes that are involved for a proper maintenance of a healthy periodontium in mice. Null mutations of genes required for leukocyte cell-cell recognition and extravasation (e.g., Icam-1, P-selectin, Beta2-integrin/Cd18), for pathogen recognition and killing (e...
2017: Frontiers in Immunology
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