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https://www.readbyqxmd.com/read/27729867/targeting-heat-shock-proteins-mitigates-ventilator-induced-diaphragm-muscle-dysfunction-in-an-age-dependent-manner
#1
Hannah Ogilvie, Nicola Cacciani, Hazem Akkad, Lars Larsson
Intensive care unit (ICU) patients are often overtly subjected to mechanical ventilation and immobilization, which leads to impaired limb and respiratory muscle function. The latter, termed ventilator-induced diaphragm dysfunction (VIDD) has recently been related to compromised heat shock protein (Hsp) activation. The administration of a pharmacological drug BGP-15 acting as a Hsp chaperone co-inducer has been found to partially alleviate VIDD in young rats. Considering that the mean age in the ICU is increasing, we aimed to explore whether the beneficial functional effects are also present in old rats...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27488897/the-chaperone-co-inducer-bgp-15-alleviates-ventilation-induced-diaphragm-dysfunction
#2
Heba Salah, Meishan Li, Nicola Cacciani, Stefano Gastaldello, Hannah Ogilvie, Hazem Akkad, Arvind Venkat Namuduri, Valeria Morbidoni, Konstantin A Artemenko, Gabor Balogh, Vicente Martinez-Redondo, Paulo Jannig, Yvette Hedström, Barry Dworkin, Jonas Bergquist, Jorge Ruas, Laszlo Vigh, Leonardo Salviati, Lars Larsson
Ventilation-induced diaphragm dysfunction (VIDD) is a marked decline in diaphragm function in response to mechanical ventilation, which has negative consequences for individual patients' quality of life and for the health care system, but specific treatment strategies are still lacking. We used an experimental intensive care unit (ICU) model, allowing time-resolved studies of diaphragm structure and function in response to long-term mechanical ventilation and the effects of a pharmacological intervention (the chaperone co-inducer BGP-15)...
August 3, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27457930/leaky-ryanodine-receptors-contribute-to-diaphragmatic-weakness-during-mechanical-ventilation
#3
Stefan Matecki, Haikel Dridi, Boris Jung, Nathalie Saint, Steven R Reiken, Valérie Scheuermann, Ségolène Mrozek, Gaetano Santulli, Alisa Umanskaya, Basil J Petrof, Samir Jaber, Andrew R Marks, Alain Lacampagne
Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understood. Here, we show in human subjects and a mouse model of VIDD that MV is associated with rapid remodeling of the sarcoplasmic reticulum (SR) Ca(2+) release channel/ryanodine receptor (RyR1) in the diaphragm...
August 9, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27055225/inhibition-of-src-and-forkhead-box-o1-signaling-by-induced-pluripotent-stem-cell-therapy-attenuates-hyperoxia-augmented-ventilator-induced-diaphragm-dysfunction
#4
Li-Fu Li, Yuh-Lih Chang, Ning-Hung Chen, Chien-Ying Wang, Gwo-Jyh Chang, Meng-Chih Lin, Chih-Hao Chang, Chung-Chi Huang, Jen-Hua Chuang, Yi-Pin Yang, Shih-Hwa Chiou, Yung-Yang Liu
Mechanical ventilation (MV) with hyperoxia is required for providing life support to patients with acute lung injury (ALI). However, MV may cause diaphragm weakness through muscle injury and atrophy, an effect termed ventilator-induced diaphragm dysfunction (VIDD). Src protein tyrosine kinase and class O of forkhead box 1 (FoxO1) mediate acute inflammatory responses and muscle protein degradation induced by oxidative stress. Induced pluripotent stem cells (iPSCs) have been reported to improve hyperoxia-augmented ALI; however, the mechanisms regulating the interactions among VIDD, hyperoxia, and iPSCs are unclear...
July 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27030815/dysfunction-of-respiratory-muscles-in-critically-ill-patients-on-the-intensive-care-unit
#5
REVIEW
David Berger, Stefan Bloechlinger, Stephan von Haehling, Wolfram Doehner, Jukka Takala, Werner J Z'Graggen, Joerg C Schefold
Muscular weakness and muscle wasting may often be observed in critically ill patients on intensive care units (ICUs) and may present as failure to wean from mechanical ventilation. Importantly, mounting data demonstrate that mechanical ventilation itself may induce progressive dysfunction of the main respiratory muscle, i.e. the diaphragm. The respective condition was termed 'ventilator-induced diaphragmatic dysfunction' (VIDD) and should be distinguished from peripheral muscular weakness as observed in 'ICU-acquired weakness (ICU-AW)'...
September 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/26948253/effect-of-theophylline-on-ventilator-induced-diaphragmatic-dysfunction
#6
Won-Young Kim, So Hee Park, Won Young Kim, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Chae-Man Lim
PURPOSE: To evaluate the effect of theophylline in patients with ventilator-induced diaphragmatic dysfunction (VIDD). MATERIALS AND METHODS: Patients who required mechanical ventilation at least 72 hours, met the criteria for a spontaneous breathing trial, and had evidence of VIDD by ultrasonography were included in the study. RESULTS: Of the 40 patients, 21 received theophylline and 19 did not. Clinical characteristics were similar in the 2 groups...
June 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/26639081/the-course-of-diaphragm-atrophy-in-ventilated-patients-assessed-with-ultrasound-a-longitudinal-cohort-study
#7
Tom Schepens, Walter Verbrugghe, Karolien Dams, Bob Corthouts, Paul M Parizel, Philippe G Jorens
INTRODUCTION: Mechanical ventilation and the effect of respiratory muscle unloading on the diaphragm cause ventilator-induced diaphragmatic dysfunction (VIDD). Atrophy of the diaphragmatic muscle is a major part of VIDD, and has a rapid onset in most animal models. We wanted to assess the clinical evolution and risk factors for VIDD in an adult intensive care unit (ICU) by measuring diaphragm thickness using ultrasound. METHOD: We performed a single-centre observational cohort study, including 54 mechanically ventilated patients...
December 7, 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26627540/ventilator-induced-diaphragmatic-dysfunction-what-have-we-learned
#8
REVIEW
Basil J Petrof, Sabah N Hussain
PURPOSE OF REVIEW: The purpose of the review is to summarize and discuss recent research regarding the role of mechanical ventilation in producing weakness and atrophy of the diaphragm in critically ill patients, an entity termed ventilator-induced diaphragmatic dysfunction (VIDD). RECENT FINDINGS: Severe weakness of the diaphragm is frequent in mechanically ventilated patients, in whom it contributes to poor outcomes including increased mortality. Significant progress has been made in identifying the molecular mechanisms responsible for VIDD in animal models, and there is accumulating evidence for occurrence of the same cellular processes in the diaphragms of human patients undergoing prolonged mechanical ventilation...
February 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/26472866/cervical-spinal-cord-injury-exacerbates-ventilator-induced-diaphragm-dysfunction
#9
Ashley J Smuder, Elisa J Gonzalez-Rothi, Oh Sung Kwon, Aaron B Morton, Kurt J Sollanek, Scott K Powers, David D Fuller
Cervical spinal cord injury (SCI) can dramatically impair diaphragm muscle function and often necessitates mechanical ventilation (MV) to maintain adequate pulmonary gas exchange. MV is a life-saving intervention. However, prolonged MV results in atrophy and impaired function of the diaphragm. Since cervical SCI can also trigger diaphragm atrophy, it may create preconditions that exacerbate ventilator-induced diaphragm dysfunction (VIDD). Currently, no drug therapy or clinical standard of care exists to prevent or minimize diaphragm dysfunction following SCI...
January 15, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/25828754/relationship-between-autophagy-and-ventilator-induced-diaphragmatic-dysfunction
#10
Ilan Azuelos, Boris Jung, Martin Picard, Feng Liang, Tong Li, Christian Lemaire, Christian Giordano, Sabah Hussain, Basil J Petrof
BACKGROUND: Mechanical ventilation (MV) is associated with atrophy and weakness of the diaphragm muscle, a condition termed ventilator-induced diaphragmatic dysfunction (VIDD). Autophagy is a lysosomally mediated proteolytic process that can be activated by oxidative stress, which has the potential to either mitigate or exacerbate VIDD. The primary goals of this study were to (1) determine the effects of MV on autophagy in the diaphragm and (2) evaluate the impact of antioxidant therapy on autophagy induction and MV-induced diaphragmatic weakness...
June 2015: Anesthesiology
https://www.readbyqxmd.com/read/25571991/role-of-intrinsic-aerobic-capacity-and-ventilator-induced-diaphragm-dysfunction
#11
Kurt J Sollanek, Ashley J Smuder, Michael P Wiggs, Aaron B Morton, Lauren G Koch, Steven L Britton, Scott K Powers
Prolonged mechanical ventilation (MV) leads to rapid diaphragmatic atrophy and contractile dysfunction, which is collectively termed "ventilator-induced diaphragm dysfunction" (VIDD). Interestingly, endurance exercise training prior to MV has been shown to protect against VIDD. Further, recent evidence reveals that sedentary animals selectively bred to possess a high aerobic capacity possess a similar skeletal muscle phenotype to muscles from endurance trained animals. Therefore, we tested the hypothesis that animals with a high intrinsic aerobic capacity would naturally be afforded protection against VIDD...
April 1, 2015: Journal of Applied Physiology
https://www.readbyqxmd.com/read/25496650/-consequences-of-mechanical-ventilation-on-diaphragmatic-function
#12
REVIEW
B Jung, D Gleeton, A Daurat, M Conseil, M Mahul, G Rao, S Matecki, A Lacampagne, S Jaber
INTRODUCTION: Mechanical ventilation is associated with ventilator-induced diaphragmatic dysfunction (VIDD) in animal models and also in humans. BACKGROUND: The main pathophysiological pathways implicated in VIDD seems to be related to muscle inactivity but may also be the consequence of high tidal volumes. Systemic insults from side effects of medication, infection, malnutrition and hypoperfusion also play a part. The diaphragm is caught in the cross-fire of ventilation-induced and systemic-induced dysfunctions...
April 2015: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/25286450/the-jak-stat-pathway-is-critical-in-ventilator-induced-diaphragm-dysfunction
#13
Huibin Tang, Ira J Smith, Sabah N A Hussain, Peter Goldberg, Myung Lee, Sista Sugiarto, Guillermo L Godinez, Baljit K Singh, Donald G Payan, Thomas A Rando, Todd M Kinsella, Joseph B Shrager
Mechanical ventilation (MV) is one of the lynchpins of modern intensive-care medicine and is life saving in many critically ill patients. Continuous ventilator support, however, results in ventilation-induced diaphragm dysfunction (VIDD) that likely prolongs patients' need for MV and thereby leads to major associated complications and avoidable intensive care unit (ICU) deaths. Oxidative stress is a key pathogenic event in the development of VIDD, but its regulation remains largely undefined. We report here that the JAK-STAT pathway is activated in MV in the human diaphragm, as evidenced by significantly increased phosphorylation of JAK and STAT...
2014: Molecular Medicine
https://www.readbyqxmd.com/read/24681580/inhibition-of-the-ubiquitin-proteasome-pathway-does-not-protect-against-ventilator-induced-accelerated-proteolysis-or-atrophy-in-the-diaphragm
#14
Ashley J Smuder, W Bradley Nelson, Matthew B Hudson, Andreas N Kavazis, Scott K Powers
BACKGROUND: Mechanical ventilation (MV) is a life-saving intervention in patients with acute respiratory failure. However, prolonged MV results in ventilator-induced diaphragm dysfunction (VIDD), a condition characterized by both diaphragm fiber atrophy and contractile dysfunction. Previous work has shown that calpain, caspase-3, and the ubiquitin-proteasome pathway (UPP) are all activated in the diaphragm during prolonged MV. However, although it is established that both calpain and caspase-3 are important contributors to VIDD, the role that the UPP plays in the development of VIDD remains unknown...
July 2014: Anesthesiology
https://www.readbyqxmd.com/read/24475293/recovery-of-diaphragm-function-following-mechanical-ventilation-in-a-rodent-model
#15
Christian S Bruells, Ingmar Bergs, Rolf Rossaint, Jun Du, Christian Bleilevens, Andreas Goetzenich, Joachim Weis, Michael P Wiggs, Scott K Powers, Marc Hein
BACKGROUND: Mechanical ventilation (MV) induces diaphragmatic muscle fiber atrophy and contractile dysfunction (ventilator induced diaphragmatic dysfunction, VIDD). It is unknown how rapidly diaphragm muscle recovers from VIDD once spontaneous breathing is restored. We hypothesized that following extubation, the return to voluntary breathing would restore diaphragm muscle fiber size and contractile function using an established rodent model. METHODS: Following 12 hours of MV, animals were either euthanized or, after full wake up, extubated and returned to voluntary breathing for 12 hours or 24 hours...
2014: PloS One
https://www.readbyqxmd.com/read/24306096/-ventilator-induced-diaphragm-dysfunction-clinically-relevant-problem
#16
REVIEW
C S Bruells, G Marx, R Rossaint
Mechanical ventilation is a life-saving intervention for patients with respiratory failure or during deep sedation. During continuous mandatory ventilation the diaphragm remains inactive, which activates pathophysiological cascades leading to a loss of contractile force and muscle mass (collectively referred to as ventilator-induced diaphragm dysfunction, VIDD). In contrast to peripheral skeletal muscles this process is rapid and develops after as little as 12 h and has a profound influence on weaning patients from mechanical ventilation as well as increased incidences of morbidity and mortality...
January 2014: Der Anaesthesist
https://www.readbyqxmd.com/read/24137680/negative-pressure-ventilation-and-positive-pressure-ventilation-promote-comparable-levels-of-ventilator-induced-diaphragmatic-dysfunction-in-rats
#17
COMPARATIVE STUDY
Christian S Bruells, Ashley J Smuder, Lucy K Reiss, Matthew B Hudson, William Bradley Nelson, Michael P Wiggs, Kurt J Sollanek, Rolf Rossaint, Stefan Uhlig, Scott K Powers
BACKGROUND: Mechanical ventilation is a life-saving intervention for patients with respiratory failure. Unfortunately, a major complication associated with prolonged mechanical ventilation is ventilator-induced diaphragmatic atrophy and contractile dysfunction, termed ventilator-induced diaphragmatic dysfunction (VIDD). Emerging evidence suggests that positive pressure ventilation (PPV) promotes lung damage (ventilator-induced lung injury [VILI]), resulting in the release of signaling molecules that foster atrophic signaling in the diaphragm and the resultant VIDD...
September 2013: Anesthesiology
https://www.readbyqxmd.com/read/23950950/prolonged-mechanical-ventilation-alters-the-expression-pattern-of-angio-neogenetic-factors-in-a-pre-clinical-rat-model
#18
Christian S Bruells, Karen Maes, Rolf Rossaint, Debby Thomas, Nele Cielen, Christian Bleilevens, Ingmar Bergs, Ursina Loetscher, Agnes Dreier, Ghislaine Gayan-Ramirez, Brad J Behnke, Joachim Weis
OBJECTIVE: Mechanical ventilation (MV) is a life saving intervention for patients with respiratory failure. Even after 6 hours of MV, diaphragm atrophy and dysfunction (collectively referred to as ventilator-induced diaphragmatic dysfunction, VIDD) occurs in concert with a blunted blood flow and oxygen delivery. The regulation of hypoxia sensitive factors (i.e. hypoxia inducible factor 1α, 2α (HIF-1α,-2α), vascular endothelial growth factor (VEGF)) and angio-neogenetic factors (angiopoietin 1-3, Ang) might contribute to reactive and compensatory alterations in diaphragm muscle...
2013: PloS One
https://www.readbyqxmd.com/read/23842681/ventilator-induced-diaphragm-dysfunction-cause-and-effect
#19
REVIEW
Scott K Powers, Michael P Wiggs, Kurt J Sollanek, Ashley J Smuder
Mechanical ventilation (MV) is used clinically to maintain gas exchange in patients that require assistance in maintaining adequate alveolar ventilation. Common indications for MV include respiratory failure, heart failure, drug overdose, and surgery. Although MV can be a life-saving intervention for patients suffering from respiratory failure, prolonged MV can promote diaphragmatic atrophy and contractile dysfunction, which is referred to as ventilator-induced diaphragm dysfunction (VIDD). This is significant because VIDD is thought to contribute to problems in weaning patients from the ventilator...
September 2013: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/23838714/negative-pressure-ventilation-and-positive-pressure-ventilation-promote-comparable-levels-of-ventilator-induced-diaphragmatic-dysfunction-in-rats
#20
COMPARATIVE STUDY
Christian S Bruells, Ashley J Smuder, Lucy K Reiss, Matthew B Hudson, William Bradley Nelson, Michael P Wiggs, Kurt J Sollanek, Rolf Rossaint, Stefan Uhlig, Scott K Powers
BACKGROUND: Mechanical ventilation is a life-saving intervention for patients with respiratory failure. Unfortunately, a major complication associated with prolonged mechanical ventilation is ventilator-induced diaphragmatic atrophy and contractile dysfunction, termed ventilator-induced diaphragmatic dysfunction (VIDD). Emerging evidence suggests that positive pressure ventilation (PPV) promotes lung damage (ventilator-induced lung injury [VILI]), resulting in the release of signaling molecules that foster atrophic signaling in the diaphragm and the resultant VIDD...
September 2013: Anesthesiology
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