keyword
MENU ▼
Read by QxMD icon Read
search

Coronary physiology

keyword
https://www.readbyqxmd.com/read/29155799/risk-of-prevalent-and-incident-dementia-associated-with-insulin-like-growth-factor-and-insulin-like-growth-factor-binding-protein-3
#1
O P Almeida, G J Hankey, B B Yeap, S A Paul Chubb, J Gollege, L Flicker
Insulin-like growth factor 1 (IGF-1) influences cell proliferation and survival. In the extracellular environment, IGF-1 circulates bound to proteins (IGF-binding proteins; IGFBP), some of which have physiological effects that seem independent of IGF-1, including the brain (for example, IGFBP-3). We completed a systematic review of the association between dementia and IGF-1 and IGFBP-3, and a cross-sectional and longitudinal study designed to investigate if lower plasma concentration of these proteins increased the risk of prevalent and incident dementia...
July 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29155383/efficacy-of-optical-coherence-tomography-derived-morphometric-assessment-in-predicting-the-physiological-significance-of-coronary-stenosis-head-to-head-comparison-with-intravascular-ultrasound
#2
Eisuke Usui, Taishi Yonetsu, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Rikuta Hamaya, Yoshinori Kanno, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
AIMS: This study aimed to investigate the diagnostic efficacy of optical coherence tomography (OCT) in identifying functional significance via fractional flow reserve (FFR) compared with that of intravascular ultrasound (IVUS). METHODS AND RESULTS: We investigated 203 de novo intermediate coronary lesions of 186 patients who underwent frequency-domain OCT, IVUS and FFR measurements. Diagnostic efficacy of the minimal lumen area (MLA) obtained by OCT (OCT-MLA) and IVUS (IVUS-MLA) in predicting an FFR<0...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29155072/a-protocol-to-study-ex-vivo-mouse-working-heart-at-human-like-heart-rate
#3
Han-Zhong Feng, Jian-Ping Jin
Genetically modified mice are widely used as experimental models to study human heart function and diseases. However, the fast rate of normal mouse heart at 400-600bpm limits its capacity of assessing kinetic parameters that are important for the physiology and pathophysiology of human heart that beats at a much slower rate (75-180bpm). To extend the value of mouse models, we established a protocol to study ex vivo mouse working hearts at a human-like heart rate. In the presence of 300μM lidocaine to lower pacemaker and conductive activities and prevent arrhythmia, a stable rate of 120-130bpm at 37°C is achieved for ex vivo mouse working hearts...
November 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29146670/three-vessel-assessment-of-coronary-microvascular-dysfunction-in-patients-with-clinical-suspicion-of-ischemia-prospective-observational-study-with-the-index-of-microcirculatory-resistance
#4
Yuhei Kobayashi, Joo Myung Lee, William F Fearon, Jang Hoon Lee, Takeshi Nishi, Dong-Hyun Choi, Frederik M Zimmermann, Ji-Hyun Jung, Hyun-Jung Lee, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Bon-Kwon Koo
BACKGROUND: Difficulty directly visualizing the coronary microvasculature as opposed to the epicardial coronary artery makes its assessment challenging. The goal of this study is to measure the index of microcirculatory resistance (IMR) in all 3 major coronary vessels to identify the clinical and angiographic predictors of an abnormal IMR. METHODS AND RESULTS: Ninety-three patients who underwent coronary physiological assessment in all 3 major coronary vessels were prospectively enrolled (59...
November 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29137693/another-chance-at-life-jordanian-patients-experience-of-going-through-a-myocardial-infarction
#5
Ali Ahmad Ammouri, Joy Kabasindi Kamanyire, Ahmad H Abu Raddaha, Susan Achora, Arwa Atef Obeidat
BACKGROUND AND PURPOSE: Myocardial infarction (MI) is a life-threatening health condition that has physical, spiritual, emotional, and social changes. Understanding feelings and thoughts of patients who suffered MI attacks is essential to recovery. Among Jordanian patients who suffered an acute attack of MI, the aim of the study was to describe the experiences and the varied meanings that they assign to their experiences. METHODS: A qualitative hermeneutic phenomenological research design was used...
November 1, 2017: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29130961/endothelial-cell-derived-microparticles-from-patients-with-obstructive-sleep-apnea-hypoxia-syndrome-and-coronary-artery-disease-increase-aortic-endothelial-cell-dysfunction
#6
Lixin Jia, Jingyao Fan, Wei Cui, Sa Liu, Na Li, Wayne Bond Lau, Xinliang Ma, Jie Du, Shaoping Nie, Yongxiang Wei
BACKGROUND/AIMS: Obstructive sleep apnea hypoxia syndrome (OSAHS) is an independent risk factor for coronary artery disease (CAD). Treatment of OSAHS improves clinical outcome in some CAD patients, but the relationship between OSAHS and CAD is complex. Microparticles (MPs) are shed by the plasma membrane by either physiologic or pathologic stimulation. In the current study, we investigated the role of MPs in the context of OSAHS. METHODS AND RESULTS: 54 patients with both suspected coronary artery stenosis and OSAHS were recruited and underwent both coronary arteriography and polysomnography...
November 1, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29121932/hemodynamics-analysis-of-the-serial-stenotic-coronary-arteries
#7
Xin Liu, Changnong Peng, Yufa Xia, Zhifan Gao, Pengcheng Xu, Xiaoqing Wang, Zhanchao Xian, Youbing Yin, Liqun Jiao, Defeng Wang, Lin Shi, Wenhua Huang, Xin Liu, Heye Zhang
Coronary arterial stenoses, particularly serial stenoses in a single branch, are responsible for complex hemodynamic properties of the coronary arterial trees, and the uncertain prognosis of invasive intervention. Critical information of the blood flow redistribution in the stenotic arterial segments is required for the adequate treatment planning. Therefore, in this study, an image based non-invasive functional assessment is performed to investigate the hemodynamic significances of serial stenoses. Twenty patient-specific coronary arterial trees with different combinations of stenoses were reconstructed from the computer tomography angiography for the evaluation of the hemodynamics...
November 9, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29121234/optimizing-percutaneous-coronary-interventions-heart-team-syntax-ii-score-physiology-and-imaging-guidance-modern-stents-and-guideline-based-medication
#8
Thomas F Lüscher
No abstract text is available yet for this article.
November 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29113999/index-of-microcirculatory-resistance-at-the-time-of-primary-percutaneous-coronary-intervention-predicts-early-cardiac-complications-insights-from-the-oxami-oxford-study-in-acute-myocardial-infarction-cohort
#9
Gregor Fahrni, Mathias Wolfrum, Giovanni Luigi De Maria, Florim Cuculi, Sam Dawkins, Mohammad Alkhalil, Niket Patel, John C Forfar, Bernard D Prendergast, Robin P Choudhury, Keith M Channon, Adrian P Banning, Rajesh K Kharbanda
BACKGROUND: Early risk stratification after primary percutaneous coronary intervention (PPCI) for ST-segment-elevation myocardial infarction is currently challenging. Identification of a low-risk group may improve triage of patients to alternative clinical pathways and support early hospital discharge. Our aim was to assess whether the index of microcirculatory resistance (IMR) at the time of PPCI can identify patients at low risk of early major cardiac complications and to compare its performance against guideline-recommended risk scores...
November 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29113864/observations-from-a-real-time-ifr-ffr-hybrid-approach-in-patients-with-severe-aortic-stenosis-and-coronary-artery-disease-undergoing-tavi
#10
Roberto Scarsini, Gabriele Pesarini, Mattia Lunardi, Anna Piccoli, Claudia Zanetti, Rosaria Cantone, Michele Bellamoli, Valeria Ferrero, Leonardo Gottin, Giuseppe Faggian, Flavio Ribichini
BACKGROUND: The complexity of coronary physiology in presence of severe aortic stenosis (AS) raises concerns about the reliability of pressure-derived indexes in this clinical setting. Furthermore, neither fractional flow reserve (FFR) nor instantaneous wave-free period (iFR) has been validated in AS. Combining iFR and FFR in a tailored decision-making strategy may help to increase simplicity, accuracy and safety of physiology-guided revascularization in AS. METHODS: In this prospective observational study iFR and FFR were measured before and after TAVI during the same procedure in patients with severe AS and concomitant coronary artery disease (CAD)...
October 3, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29110409/coronary-microvascular-kv1-channels-as-regulatory-sensors-of-intracellular-pyridine-nucleotide-redox-potential
#11
Marc M Dwenger, Vahagn Ohanyan, Manuel F Navedo, Matthew A Nystoriak
Smooth muscle voltage-gated potassium (Kv) channels are important regulators of microvascular tone and tissue perfusion. Recent studies indicate that Kv1 channels represent a key component of the physiological coupling between coronary blood flow and myocardial oxygen demand. While the mechanisms by which metabolic changes in the heart are transduced to alter coronary Kv1 channel gating and promote vasodilation are unclear, a growing body of evidence underscores a pivotal role of Kv1 channels in sensing the cellular redox status...
November 7, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29105325/coronary-resting-gradients-for-hemodynamic-lesion-assessment-the-future-of-coronary-physiology
#12
EDITORIAL
Evan Shlofmitz, Allen Jeremias
Coronary resting gradient measurements with cut-off values of ≤0.87 and ≥0.93 portend a high degree of certainty with respect to appropriateness of coronary revascularization Less agreement exists in patients in the so called indeterminate "gray zone" Pressure-bounded coronary flow reserve may aid in our understanding of the underlying physiologic principles and facilitate the clinical assessment of these lesions.
November 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29104545/the-adenosine-hypothesis-revisited-modulation-of-coupling-between-myocardial-perfusion-and-arterial-compliance
#13
Geoffrey P Dobson, Aryadi Arsyad, Hayley L Letson
For over four decades the thoracic aortic ring model has become one of the most widely used methods to study vascular reactivity and electromechanical coupling. A question that is rarely asked, however, is what function does a drug-mediated relaxation (or contraction) in this model serve in the intact system? The physiological significance of adenosine relaxation in rings isolated from large elastic conduit arteries from a wide range of species remains largely unknown. We propose that adenosine relaxation increases aortic compliance in acute stress states and facilitates ventricular-arterial (VA) coupling, and thereby links compliance and coronary artery perfusion to myocardial energy metabolism...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29103734/relationship-between-optical-coherence-tomography-derived-morphological-criteria-and-functional-relevance-as-determined-by-fractional-flow-reserve
#14
Eisuke Usui, Taishi Yonetsu, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Tadashi Fukuda, Hiroaki Ohya, Yohei Sumino, Rikuta Hamaya, Yoshinori Kanno, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
BACKGROUND: Although several previous studies have indicated that optical coherence tomography (OCT)-derived minimal lumen area (MLA) correlates with fractional flow reserve (FFR) severity, other morphologic criteria for functionally significant coronary stenosis assessed by FFR have not been fully elucidated. This study aimed to identify OCT-based morphological predictors of physiologically significant ischemia assessed by FFR in angiographically intermediate coronary lesions. METHODS: We investigated 194 de novo intermediate coronary lesions in 178 patients with stable angina pectoris who underwent OCT imaging and FFR measurement...
November 2, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29102035/impact-of-hypothyroidism-on-occurrence-and-outcome-of-acute-coronary-syndrome-from-the-national-inpatient-sample
#15
Rashmi Dhital, Sijan Basnet, Dilli Ram Poudel
Thyroid hormones have a profound effect on cardiovascular physiology. We utilized a large national inpatient database in the United States (National Inpatient Sample) to study hypothyroidism in relation to the prevalence of coronary heart disease (CHD) and its impact on outcomes (mortality, the length of stay, and hospitalization cost) in the acute coronary syndrome (ACS) subgroup of CHD patients. We found that although hypothyroidism has an increased association with CHD (odds ratio [OR] 1.11, 95% confidence interval [CI] 1...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29095792/important-role-of-endothelial-caveolin-1-in-the-protective-role-of-edh-against-no-mediated-nitrative-stress-in-microcirculation-in-mice
#16
Hiroki Saito, Shigeo Godo, Saori Sato, Akiyo Ito, Yosuke Ikumi, Shuhei Tanaka, Tomoaki Ida, Shigemoto Fujii, Takaaki Akaike, Hiroaki Shimokawa
AIMS: Nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in maintaining cardiovascular homeostasis. We have previously demonstrated that endothelial NO synthase (eNOS) plays diverse roles depending on vessel size, as a NO generating system in conduit arteries and an EDH-mediated system in resistance arteries, for which caveolin-1(Cav-1) is involved. However, the physiological role of endothelial Cav-1 in microvessels remains to be elucidated. METHODS AND RESULTS: We newly generated endothelium-specific Cav-1-knockout (eCav-1-KO) mice...
October 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29092125/significant-drop-in-right-atrial-pressure-does-not-influence-fractional-flow-reserve-coronary-assessment
#17
Roberto Scarsini, Gabriele Pesarini, Fausto Castriota, Corrado Vassanelli, Flavio Ribichini
The effect of a highly elevated level of right atrial filling pressure on fractional flow reserve (FFR) measurement remains unclear. Transcatheter tricuspid valve intervention, a recently introduced option for inoperable or high-risk patients, represents a unique model of in-vivo physiology to investigate the eventual influence of central venous pressure on coronary FFR measurements. The case is reported of a patient with a degenerated tricuspid surgical bioprosthesis who underwent transcatheter tricuspid valve-in-valve replacement and concomitant coronary functional assessment with FFR...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29089640/acute-and-long-term-cardioprotective-effects-of-the-traditional-chinese-medicine-mlc901-against-myocardial-ischemia-reperfusion-injury-in-mice
#18
Anne Vincent, Aurélie Covinhes, Christian Barrère, Laura Gallot, Soulit Thoumala, Christophe Piot, Catherine Heurteaux, Michel Lazdunski, Joël Nargeot, Stéphanie Barrère-Lemaire
MLC901, a traditional Chinese medicine containing a cocktail of active molecules, both reduces cerebral infarction and improves recovery in patients with ischemic stroke. The aim of this study was to evaluate the acute and long-term benefits of MLC901 in ischemic and reperfused mouse hearts. Ex vivo, under physiological conditions, MLC901 did not show any modification in heart rate and contraction amplitude. However, upon an ischemic insult, MLC901 administration during reperfusion, improved coronary flow in perfused hearts...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29081845/the-effects-of-aerobic-and-anaerobic-exercises-on-circulating-soluble-klotho-and-igf-i-in-young-and-elderly-adults-and-in-cad-patients
#19
REVIEW
Moran S Saghiv, D Ben Sira, E Goldhammer, M Sagiv
Different studies support the notion that chronic aerobic exercises training can influence the circulating levels of soluble-Klotho (s-Klotho) and insulin-like growth factor 1 (IGF-I). The effects of s-Klotho include improving the quality of life, alleviating the negative impact of age on the body's work capacity, and possibly increasing longevity. This review provides an overview of the latest findings in this field of research in humans. The different modes of dynamic exercise and their impact on circulating levels of s-Klotho and IGF-I in young adult athletes, untrained young adults, trained healthy older adults, untrained healthy older adults, and coronary artery disease (CAD) patients are reviewed and discussed...
January 2017: J Circ Biomark
https://www.readbyqxmd.com/read/29077507/multi-ethnic-meta-analysis-identifies-rai1-as-a-possible-obstructive-sleep-apnea-related-quantitative-trait-locus-in-men
#20
Han Chen, Brian E Cade, Kevin J Gleason, Andrew C Bjonnes, Adrienne M Stilp, Tamar Sofer, Matthew P Conomos, Sonia Ancoli-Israel, Raanan Arens, Ali Azarbarzin, Graeme I Bell, Jennifer E Below, Sung Chun, Daniel S Evans, Ralf Ewert, Alexis C Frazier-Wood, Sina A Gharib, José Haba-Rubio, Erika W Hagen, Raphael Heinzer, David R Hillman, W Craig Johnson, Zoltan Kutalik, Jacqueline M Lane, Emma K Larkin, Seung Ku Lee, Jingjing Liang, Jose S Loredo, Sutapa Mukherjee, Lyle J Palmer, George J Papanicolaou, Thomas Penzel, Paul E Peppard, Wendy S Post, Alberto R Ramos, Ken Rice, Jerome I Rotter, Scott A Sands, Neomi A Shah, Chol Shin, Katie L Stone, Beate Stubbe, Jae-Hoon Sul, Mehdi Tafti, Kent D Taylor, Alexander Teumer, Timothy A Thornton, Gregory J Tranah, Chaolong Wang, Heming Wang, Simon C Warby, D Andrew Wellman, Phyllis C Zee, Craig L Hanis, Cathy C Laurie, Daniel J Gottlieb, Sanjay R Patel, Xiaofeng Zhu, Shamil R Sunyaev, Richa Saxena, Xihong Lin, Susan Redline
Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups and a large proportion of the heritability remains unexplained. The apnea hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Since OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multi-ethnic samples...
October 27, 2017: American Journal of Respiratory Cell and Molecular Biology
keyword
keyword
22430
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"