Natan Roberto de Barros, Ankit Gangrade, Ahmad Elsebahy, RunRun Chen, Fatemeh Zehtabi, Menekse Ermis, Natashya Falcone, Reihaneh Haghniaz, Safoora Khosravi, Alejandro Gomez, Shuyi Huang, Marvin Mecwan, Danial Khorsandi, Junmin Lee, Yangzhi Zhu, Bingbing Li, HanJun Kim, Finosh G Thankam, Ali Khademhosseini
Enterocutaneous fistula (ECF) is a severe medical condition where an abnormal connection forms between the gastrointestinal tract and skin. ECFs are, in most cases, a result of surgical complications such as missed enterotomies or anastomotic leaks. The constant leakage of enteric and fecal contents from the fistula site leads to skin breakdown and increases the risk of infection. Despite advances in surgical techniques and postoperative management, ECF accounts for significant mortality rates, estimated between 15-20%, and causes debilitating morbidity...
January 2024: Acta Biomaterialia