Zhiyuan Wang, Renfeng Liu, Youjun Liu, Yuqi Zhao, Yuhao Wang, Botao Lu, Hui Li, Cheng Ju, Weidong Wu, Xinlin Gao, Hailiang Xu, Shixiang Cheng, Yulin Cao, Shuaijun Jia, Chunping Hu, Lei Zhu, Dingjun Hao
Spinal cord organoids are of significant value in the research of spinal cord-related diseases by simulating disease states, thereby facilitating the development of novel therapies. However, the complexity of spinal cord structure and physiological functions, along with the lack of human-derived inducing components, presents challenges in the in vitro construction of human spinal cord organoids. Here, we introduce a novel human decellularized placenta-derived extracellular matrix hydrogel (DPECMH) and, combined with a new induction protocol, successfully construct human spinal cord organoids...
April 9, 2024: ACS Biomaterials Science & Engineering