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Reproductive endocrinology

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https://www.readbyqxmd.com/read/28621340/reproductive-endocrinology-elagolix-in-endometriosis
#1
Conor A Bradley
No abstract text is available yet for this article.
June 9, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28620497/painful-ovulation-in-a-46-xx-sry-ve-adult-male-with-sox9-duplication
#2
Nandini Shankara Narayana, Anne-Maree Kean, Lisa Ewans, Thomas Ohnesorg, Katie L Ayers, Geoff Watson, Arthur Vasilaras, Andrew H Sinclair, Stephen M Twigg, David J Handelsman
46,XX disorders of sexual development (DSDs) occur rarely and result from disruptions of the genetic pathways underlying gonadal development and differentiation. We present a case of a young phenotypic male with 46,XX SRY-negative ovotesticular DSD resulting from a duplication upstream of SOX9 presenting with a painful testicular mass resulting from ovulation into an ovotestis. We present a literature review of ovulation in phenotypic men and discuss the role of SRY and SOX9 in testicular development, including the role of SOX9 upstream enhancer region duplication in female-to-male sex reversal...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28601151/effect-of-season-and-age-on-scrotal-circumference-testicular-parameters-and-endocrinological-profiles-in-mithun-bulls
#3
P Perumal, N Savino, C T R Sangma, S Chang, T Z T Sangtam, M H Khan, G Singh, Brijesh Kumar, D Yadav, N Srivastava
Mithun is a domesticated free-range bovine species primarily used as a meat animal and is a pride of North Eastern Hilly regions of India. The present study was conducted to measure the effect of seasons on scrotal & testicular biometrics and endocrinological profiles for different age groups at different seasons in mithun bulls. A total of 30 mithun males were selected from the mithun breeding farm, ICAR-NRC on Mithun, Medziphema, Nagaland, India and were equally distributed into five groups based on their age...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28579417/lesbian-gay-bisexual-transgender-content-on-reproductive-endocrinology-and-infertility-clinic-websites
#4
Harold Y Wu, Ophelia Yin, Brent Monseur, Jessica Selter, Lillian J Collins, Brandyn D Lau, Mindy S Christianson
OBJECTIVE: To assess geographical distribution and practice characteristics of fertility clinics inclusive of lesbian, gay, bisexual, and transgender (LGBT) patients. DESIGN: Cross-sectional analysis. SETTING: Not applicable. PATIENT(S): None. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Prevalence and geographical distribution of fertility clinic websites with LGBT-specific content, indicated by keywords and home page cues specific to the LGBT patient population...
June 1, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28575556/-endocrinology-of-cancer-and-age-early-and-late-stages-of-ontogenesis
#5
L M Berstein
Processes important for hormone-mediated carcinogenesis are present on different, even very early, ontogenesis stages. Early shifts in hormone-metabolic status often display opposite correlations with the risk of most common age-associated non-communicable pathologies (namely, hormone-dependent cancers and cardiovascular diseases). Additional known contradiction is the raise of reproductive system tumors incidence in the age associated with lower production of mitogenic hormones. Consequently, one should take into account production of steroids in target tissues themselves, recognize the importance of progenotoxic effect, which, apart from mitogenic function, is characteristic for estrogens and their derivatives, as well as the role of endocrine-genotoxic switchings forming so called basic triad, which is born under the influence of age-associated endocrine shifts and environmental factors...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28549062/reproductive-endocrinology-cycling-through-the-menstrual-cycle-an-out-of-body-experience
#6
Donald E Ingber
No abstract text is available yet for this article.
July 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28532840/effect-of-breed-plane-of-nutrition-and-age-on-growth-scrotal-development-metabolite-concentrations-and-on-systemic-gonadotropin-and-testosterone-concentrations-following-a-gnrh-challenge-in-young-dairy-bulls
#7
C J Byrne, S Fair, A M English, C Urh, H Sauerwein, M A Crowe, P Lonergan, D A Kenny
The onset of puberty in the bull is regulated by the timing of early GnRH pulsatility release from the hypothalamus, which has been demonstrated to be affected by plane of nutrition during calf-hood. The aim of this study was to determine the effect of plane of nutrition on growth rate, scrotal development, metabolite concentrations and exogenous gonadotrophin (GnRH) induced release of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (TT) in pre-pubertal bulls of two contrasting dairy breeds...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28497815/reproductive-endocrinology-puberty-timing-and-cancer-risk
#8
David Holmes
No abstract text is available yet for this article.
July 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28492802/gonadotrophic-prolactin-corticosterone-and-gonadal-hormones-levels-over-15-months-in-giant-amazon-river-turtles-podocnemis-expansa-schweigger-1812-testudines-podocnemididae-in-captive-conditions
#9
G E Freneau, V A Sá, C R Franci, D Vieira, B N Freneau
In order to achieve successful captive breeding the Podocnemis expansa, it is necessary to study their reproductive endocrinology. The purpose of this research was to evaluate and characterize plasma concentrations in gonadotrophic, gonadic, corticosterone and prolactin hormones from Giant Amazon Turtles under captive conditions. Blood samples were collected over a 15 month period. The samples were assayed by the use of radioimmunoassay, prolactin, corticosterone, LH, FSH, testosterone, 17β-estradiol and progesterone...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28488742/feminization-of-the-fat-distribution-pattern-of-children-and-adolescents-in-a-recent-german-population
#10
Christiane Scheffler, Melanie Dammhahn
OBJECTIVES: During the early 1990s, the economic and political situation in eastern Germany changed overnight. Here, we use the rare chance of an experiment-like setting in humans and aim to test whether the rapid change of environmental conditions in eastern Germany in the 1990s led to a change in the sex-specific fat distribution pattern, an endocrine-influenced phenotypic marker. METHODS: Based on a cross-sectional data set of 6- to 18-year-old girls and boys measured between 1982-1991 and 1997-2012, we calculated a skinfold ratio of triceps to subscapular and percentage of body fat...
May 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28458884/urinary-profiles-of-progestin-and-androgen-metabolites-in-female-polar-bears-during-parturient-and-non-parturient-cycles
#11
Katrina K Knott, Gabriela F Mastromonaco, Megan A Owen, Andrew J Kouba
Due to the environmental and anthropogenic impacts that continue to threaten the reproductive success of polar bears, a more detailed understanding of their reproductive cycle is needed. Captive populations of polar bears provide an excellent opportunity to learn more about the reproductive physiology of the species. Progestin (P4) and androgen (T) metabolites in urine, and their ratio (P4:T), were examined during 11 reproductive cycles of captive female polar bears (n = 4) to characterize the steroid hormone profile during pregnancy and determine possible variations related to reproductive failure...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28458460/childbirth-and-fertility-preservation-in-childhood-and-adolescent-cancer-patients-a-second-national-survey-of-japanese-pediatric-endocrinologists
#12
Yoko Miyoshi, Tohru Yorifuji, Reiko Horikawa, Ikuko Takahashi, Keisuke Nagasaki, Hiroyuki Ishiguro, Ikuma Fujiwara, Junko Ito, Mari Oba, Hiroyuki Fujisaki, Masashi Kato, Chikako Shimizu, Tomoyasu Kato, Kimikazu Matsumoto, Haruhiko Sago, Tetsuya Takimoto, Hiroshi Okada, Nao Suzuki, Susumu Yokoya, Tsutomu Ogata, Keiichi Ozono
Although existing guidelines recommend long-term follow-up of childhood cancer survivors (CCSs), their fertility has not been fully investigated in Japan. To address this issue, we organized a working panel consisting of medical specialists in foundation hospitals. We conducted questionnaire surveys targeting pediatric endocrinologists regarding reproduction in pediatric and adolescent cancer patients in collaboration with the CCS committee of the Japanese Society for Pediatric Endocrinology (JSPE). The first questionnaire was sent to 178 directors or councilors of the JSPE, and the second was sent to those who had provided answers on their experience with childbirth or fertility preservation...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28429778/reproductive-endocrinology-potential-new-therapy-for-hot-flushes
#13
Claire Greenhill
No abstract text is available yet for this article.
June 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28390569/infertility-prevention-and-management
#14
REVIEW
Emily C Somers, Wendy Marder
Infertility and subfertility, menstrual irregularities, and decreased parity may occur in women with autoimmune diseases due to multiple factors, including underlying inflammatory disease, gonadotoxic medications, and psychosocial issues related to living with chronic disease. Awareness of these factors, as well as validation and support of patients confronting reproductive challenges, is important for providing comprehensive care to these women. An understanding of the expanding options for fertility preservation strategies during gonadotoxic medications is essential...
May 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28379417/subcutaneous-injection-of-testosterone-is-an-effective-and-preferred-alternative-to-intramuscular-injection-demonstration-in-female-to-male-transgender-patients
#15
Daniel I Spratt, India Stewart, Clara Savage, Wendy Craig, Norman P Spack, Donald Walt Chandler, Lindsey V Spratt, Toni Eimicke, Jerrold S Olshan
Context: Testosterone is commonly administered intramuscularly (IM) to treat hypogonadal males and female-to-male transgender (FTM) patients. However, these injections can involve significant discomfort and may require arrangements for administration by others. Objective: We assessed whether T could be administered effectively and safely by the subcutaneously (SC) as an alternative to IM injections. Design: Retrospective cohort study. Setting: Outpatient Reproductive Endocrinology Clinic at an academic medical center...
April 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28368518/functional-hypothalamic-amenorrhea-an-endocrine-society-clinical-practice-guideline
#16
Catherine M Gordon, Kathryn E Ackerman, Sarah L Berga, Jay R Kaplan, George Mastorakos, Madhusmita Misra, M Hassan Murad, Nanette F Santoro, Michelle P Warren
Cosponsoring Associations: The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28367299/low-dose-urinary-human-chorionic-gonadotropin-is-effective-for-oocyte-maturation-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles-independent-of-body-mass-index
#17
Luis R Hoyos, Sana Khan, Jing Dai, Manvinder Singh, Michael P Diamond, Elizabeth E Puscheck, Awoniyi O Awonuga
BACKGROUND: Currently, there is no agreement on the optimal urinary derived human chorionic gonadotropin (u-hCG) dose requirement for initiating final oocyte maturation prior to oocyte collection in in vitro fertilization (IVF), but doses that range from 2500- 15000 IU have been used. We intended to determine whether low dose u-hCG was effective for oocyte maturation in IVF/intracytoplasmic sperm injection (ICSI) cycles independent of body mass index (BMI). MATERIALS AND METHODS: We retrospectively evaluated a cohort of 295 women who underwent their first IVF/ICSI cycles between January 2003 and December 2010 at the Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI, USA...
April 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28345754/second-to-fourth-digit-ratio-2d-4d-is-unrelated-to-measures-of-somatic-reproductive-effort-among-young-men-from-cebu-the-philippines
#18
Alexander V Georgiev, Calen P Ryan, Lee T Gettler, Thomas W McDade, Christopher W Kuzawa
OBJECTIVES: A low second-to-fourth (2D:4D) digit ratio, a retrospective marker of high prenatal androgens, predicts increased investment in costly sexually dimorphic traits in men in some studies, although results are mixed. Here we test the hypothesis that the association of low 2D:4D ratios with increased muscularity and decreased adiposity depends on current testosterone (T) levels, such that digit ratio will be a particularly strong predictor of outcomes among men exhibiting a mating-effort-oriented endocrinological profile (high T)...
March 27, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28342856/reproductive-endocrinology-of-vitamin-d
#19
Mette Lorenzen, Ida Marie Boisen, Li Juel Mortensen, Beate Lanske, Anders Juul, Martin Blomberg Jensen
Vitamin D is a versatile hormone with several functions beyond its well-established role in maintenance of skeletal health and calcium homeostasis. The effects of vitamin D are mediated by the vitamin D receptor, which is expressed together with the vitamin D metabolizing enzymes in the reproductive tissues. The reproductive organs are therefore responsive to and able to metabolize vitamin D locally. The exact role remains to be clarified but several studies have suggested a link between vitamin D and production/release of reproductive hormones into circulation, which will be the main focus of this review...
March 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28326513/manual-vs-computer-assisted-sperm-analysis-can-casa-replace-manual-assessment-of-human-semen-in-clinical-practice
#20
Joanna Talarczyk-Desole, Anna Berger, Grażyna Taszarek-Hauke, Jan Hauke, Leszek Pawelczyk, Piotr Jedrzejczak
OBJECTIVES: The aim of the study was to check the quality of computer-assisted sperm analysis (CASA) system in comparison to the reference manual method as well as standardization of the computer-assisted semen assessment. MATERIAL AND METHODS: The study was conducted between January and June 2015 at the Andrology Laboratory of the Division of Infertility and Reproductive Endocrinology, Poznań University of Medical Sciences, Poland. The study group consisted of 230 men who gave sperm samples for the first time in our center as part of an infertility investigation...
2017: Ginekologia Polska
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