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Host-pathogen interaction

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https://www.readbyqxmd.com/read/29666630/the-interactomic-analysis-reveals-pathogenic-protein-networks-in-phomopsis-longicolla-underlying-seed-decay-of-soybean
#1
Shuxian Li, Bryan Musungu, David Lightfoot, Pingsheng Ji
Phomopsis longicolla T. W. Hobbs (syn. Diaporthe longicolla ) is the primary cause of Phomopsis seed decay (PSD) in soybean, Glycine max (L.) Merrill. This disease results in poor seed quality and is one of the most economically important seed diseases in soybean. The objectives of this study were to infer protein-protein interactions (PPI) and to identify conserved global networks and pathogenicity subnetworks in P. longicolla including orthologous pathways for cell signaling and pathogenesis. The interlog method used in the study identified 215,255 unique PPIs among 3,868 proteins...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29666211/drivers-of-persistent-infection-pathogen-induced-extracellular-vesicles
#2
REVIEW
Michael J Cipriano, Stephen L Hajduk
Extracellular vesicles (EVs) are produced by invading pathogens and also by host cells in response to infection. The origin, composition, and function of EVs made during infection are diverse and provide effective vehicles for localized and broad dissimilation of effector molecules in the infected host. Extracellular pathogens use EVs to communicate with each other by sensing the host environment contributing to social motility, tissue tropism, and persistence of infection. Pathogen-derived EVs can also interact with host cells to influence the adhesive properties of host membranes and to alter immune recognition and response...
April 17, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/29666193/lmo1656-is-a-secreted-virulence-factor-of-listeria-monocytogenes-that-interacts-with-the-sortin-nexin-6-bar-complex
#3
Daryl Jason David, Alessandro Pagliuso, Lilliana Radoshevich, Marie-Anne Nahori, Pascale Cossart
Listeria monocytogenes (Lm) is a facultative intracellular bacterial pathogen, the causative agent of listeriosis, a rare but fatal disease.  During infection, Lm can traverse several physiological barriers; it can cross the intestine and placenta, and in immunocompromised individuals, the blood-brain barrier. With the recent plethora of sequenced genomes available for Lm, it is clear that the complete repertoire of genes used by Lm to interact with its host remains to be fully explored.  Recently, we focused on secreted Lm proteins, since they are likely to interact with host cell components...
April 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29665966/beyond-r-0-maximisation-on-pathogen-evolution-and-environmental-dimensions
#4
REVIEW
Sébastien Lion, Johan A J Metz
A widespread tenet is that evolution of pathogens maximises their basic reproduction ratio, R0 . The breakdown of this principle is typically discussed as exception. Here, we argue that a radically different stance is needed, based on evolutionarily stable strategy (ESS) arguments that take account of the 'dimension of the environmental feedback loop'. The R0 maximisation paradigm requires this feedback loop to be one-dimensional, which notably excludes pathogen diversification. By contrast, almost all realistic ecological ingredients of host-pathogen interactions (density-dependent mortality, multiple infections, limited cross-immunity, multiple transmission routes, host heterogeneity, and spatial structure) will lead to multidimensional feedbacks...
April 14, 2018: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29665882/effects-of-antibiotic-resistance-ar-and-microbiota-shifts-on-campylobacter-jejuni-mediated-diseases
#5
Phillip T Brooks, Linda S Mansfield
Campylobacter jejuni is an important zoonotic pathogen recently designated a serious antimicrobial resistant (AR) threat. While most patients with C. jejuni experience hemorrhagic colitis, serious autoimmune conditions can follow including inflammatory bowel disease (IBD) and the acute neuropathy Guillain Barré Syndrome (GBS). This review examines inter-relationships among factors mediating C. jejuni diarrheal versus autoimmune disease especially AR C. jejuni and microbiome shifts. Because both susceptible and AR C...
December 2017: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29664319/accessories-make-the-outfit-accessory-chromosomes-and-other-dispensable-dna-regions-in-plant-pathogenic-fungi
#6
Stefania Bertazzoni, Angela Williams, Darcy A B Jones, Robert A Syme, Kar-Chun Tan, James Kyawzwar Hane
Fungal pathogen genomes can often be divided into core and accessory regions. Accessory regions may be comprised of either accessory regions (ARs) within core chromosomes (CCs), or wholly-dispensable (accessory) chromosomes (ACs). Fungal ACs and ARs typically accumulate mutations and structural rearrangements more rapidly over time than CCs, and many harbour genes relevant to host-pathogen interactions. These regions are of particular interest in plant pathology and include host-specific virulence factors and secondary metabolite synthesis gene clusters...
April 17, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29662839/the-saposin-like-protein-apld-displays-pore-forming-activity-and-participates-in-defense-against-bacterial-infection-during-a-multicellular-stage-of-dictyostelium-discoideum
#7
Ranjani Dhakshinamoorthy, Moritz Bitzhenner, Pierre Cosson, Thierry Soldati, Matthias Leippe
Due to their archaic life style and microbivor behavior, amoebae may represent a source of antimicrobial peptides and proteins. The amoebic protozoon Dictyostelium discoideum has been a model organism in cell biology for decades and has recently also been used for research on host-pathogen interactions and the evolution of innate immunity. In the genome of D. discoideum , genes can be identified that potentially allow the synthesis of a variety of antimicrobial proteins. However, at the protein level only very few antimicrobial proteins have been characterized that may interact directly with bacteria and help in fighting infection of D...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29662485/our-environment-shapes-us-the-importance-of-environment-and-sex-differences-in-regulation-of-autoantibody-production
#8
REVIEW
Michael Edwards, Rujuan Dai, S Ansar Ahmed
Consequential differences exist between the male and female immune systems' ability to respond to pathogens, environmental insults or self-antigens, and subsequent effects on immunoregulation. In general, females when compared with their male counterparts, respond to pathogenic stimuli and vaccines more robustly, with heightened production of antibodies, pro-inflammatory cytokines, and chemokines. While the precise reasons for sex differences in immune response to different stimuli are not yet well understood, females are more resistant to infectious diseases and much more likely to develop autoimmune diseases...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29662478/balb-c-and-c57bl-6-mice-cytokine-responses-to-trypanosoma-cruzi-infection-are-independent-of-parasite-strain-infectivity
#9
Bianca L Ferreira, Éden R Ferreira, Marlon V de Brito, Bruno R Salu, Maria L V Oliva, Renato A Mortara, Cristina M Orikaza
Trypanosoma cruzi is the etiologic agent of Chagas' disease, which affects 6-7 million people worldwide. Different strains of T. cruzi present specific genotypic and phenotypic characteristics that affect the host-pathogen interactions, and thus, the parasite has been classified into six groups (TcI to TcVI). T. cruzi infection presents two clinical phases, acute and chronic, both with distinct characteristics and important participation by the immune system. However, the specific contributions of parasite and host factors in the disease phases are not yet fully understood...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29660363/comparison-analysis-of-micrornas-in-response-to-dengue-virus-type-2-infection-between-the-vero-cell-adapted-strain-and-its-source-the-clinical-c6-36-isolated-strain
#10
Jiajia Yang, Yao Lin, Liming Jiang, Juemin Xi, Xiaodan Wang, Jiaoqiong Guan, Junying Chen, Yue Pan, Jia Luo, Chao Ye, Qiangming Sun
To elucidate the differences in microRNAs during dengue virus infection between Vero cell-adapted strain (DENV-2-Vero) and its source, the clinical C6/36 isolated strain (DENV-2-C6/36), a comparison analysis was performed in Vero cells by high throughput sequencing. The results showed that the expression of 16 known and 3 novel miRNAs exhibited marked differences. 5 known miRNAs were up-regulated in DENV-2-C6/36 group, while 11 known microRNAs were down-regulated in DENV-2-Vero group. The GO enrichment and KEGG pathway analysis showed that there was a distinct difference in regulating viral replication between two strains...
April 13, 2018: Virus Research
https://www.readbyqxmd.com/read/29660236/oxylipins-from-both-pathogen-and-host-antagonize-ja-mediated-defense-via-the-9-lipoxygenase-pathway-in-fusarium-vertcillioides-infection-of-maize
#11
Paola Battilani, Alessandra Lanubile, Valeria Scala, Massimo Reverberi, Rossella Gregori, Claudia Falavigna, Chiara Dall'Asta, Yong-Soon Park, John Bennett, Eli J Borrego, Michael V Kolomiets
Oxylipins are a newly emerging group of signals that serve either defense roles or promote virulence. To identify specific host and fungal genes and oxylipins governing the interactions between maize and Fusarium verticillioides, maize wild-type and lipoxygenase3 (lox3) mutant were inoculated with either F. verticillioides wild-type or linoleate-diol-synthase 1-deleted mutant (ΔFvlds1D). Results showed that lox3 mutants were more resistant to F. verticillioides. The reduced colonization on lox3 was associated with reduced fumonisin production and with a stronger and earlier induction of ZmLOX4, ZmLOX5, and ZmLOX12...
April 16, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29660235/inhibition-of-ossweet11-function-in-mesophyll-cells-improves-resistance-of-rice-to-sheath-blight-disease
#12
Yue Gao, Chong Zhang, Xiao Han, Zi Yuan Wang, Lai Ma, De Peng Yuan, Jing Ni Wu, Xiao Feng Zhu, Jing Miao Liu, Dao Pin Li, Yi Bing Hu, Yuan Hu Xuan
Pathogen-host interaction is a complicated process; pathogens mainly infect host plants to acquire nutrients, especially sugars. Rhizoctonia solani, the causative agent of sheath blight disease, is a major pathogen of rice. However, it is not known, as to how this pathogen obtains sugar from rice plants. In this study, we found that the rice sugar transporter, OsSWEET11 is involved in the pathogenesis of sheath blight disease. qRT-PCR and β-d-glucuronidase expression analyses showed that R. solani infection significantly enhanced OsSWEET11 expression in leaves among the clade III SWEET members...
April 16, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29659479/oral-dysbiotic-communities-and-their-implications-in-systemic-diseases
#13
REVIEW
Preethi Sudhakara, Abishek Gupta, Anshumouli Bhardwaj, Aruni Wilson
The human body supports the growth of a wide array of microbial communities in various niches such as the oral cavity, gastro-intestinal and urogenital tracts, and on the surface of the skin. These host associated microbial communities include yet-un-cultivable bacteria and are influenced by various factors. Together, these communities of bacteria are referred to as the human microbiome. Human oral microbiome consists of both symbionts and pathobionts. Deviation from symbiosis among the bacterial community leads to “dysbiosis”, a state of community disturbance...
April 16, 2018: Dentistry journal
https://www.readbyqxmd.com/read/29658778/shrangesim-simulation-of-single-nucleotide-polymorphism-clusters-in-next-generation-sequencing-data
#14
Markus Boenn
Genomic variations are in the focus of research to uncover mechanisms of host-pathogen interactions and diseases such as cancer. Nowadays, next-generation sequencing (NGS) data are analyzed through dedicated pipelines to detect them. Surrogate NGS data in conjunction with genomic variations help to evaluate pipelines and validate their outcomes, fostering selection of proper tools for a given scientific question. I describe how existing approaches for simulating NGS data in conjunction with genomic variations fail to model local enrichments of single nucleotide polymorphisms (SNPs), so called SNP clusters...
April 16, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29656244/human-organoid-cultures-transformative-new-tools-for-human-virus-studies
#15
REVIEW
Sasirekha Ramani, Sue E Crawford, Sarah E Blutt, Mary K Estes
Studies of human infectious diseases have been limited by the paucity of functional models that mimic normal human physiology and pathophysiology. Recent advances in the development of multicellular, physiologically active organotypic cultures produced from embryonic and pluripotent stem cells, as well as from stem cells isolated from biopsies and surgical specimens are allowing unprecedented new studies and discoveries about host-microbe interactions. Here, we summarize recent developments in the use of organoids for studying human viral pathogens, including intestinal infections with human rotavirus, norovirus, enteroviruses and adenoviruses (intestinal organoids and enteroids), neuronal infections with Zika virus (cerebral organoids) and respiratory infections with respiratory syncytial virus in (lung bud organoids)...
April 12, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29655887/engineering-riboswitch-in-l-major-from-prediction-to-conceptualization
#16
Pruthvi Raj Bejugam, Shailza Singh
Post-transcriptional gene regulation is a vital process to regulate expression of the key genes in the eukaryotic cell. Such processes are essential for pathogens which reside inside the host cell. One such pathogen is Leishmania major, which causes cutaneous leishmaniasis. The parasite lives inside the macrophages of mammalian host (mostly human). Inside the macrophage, Leishmania genes show complex host-pathogen interaction regulating a plethora of gene expression. Till date, most of the studies have shown this kind of regulation with respect to the host macrophages...
April 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29655789/interleukin-enhanced-binding-factor-2-interacts-with-nlrp3-to-inhibit-the-nlrp3-inflammasome-activation
#17
Jing Jin, Aixin Li, Wenbiao Wang, Jianguo Wu
The activation of the NLRP3 inflammasome is a key process of host immune response that establishes the first line of defense against pathogen infections and cellular stresses, whereas excessive inflammasome activation may damage the hosts, and thus it must be precisely controlled. However, the mechanism underlying the repression of the NLRP3 inflammasome activation remains largely unknown. In this study, by establishing and using a reconstructed NLRP3 inflammasome activation system, we reveal that the NLRP3 inflammasome activation, pro-caspase-1 cleavage, and pro-interleukin-1β (pro-IL-1β) activation are repressed by the interleukin-enhanced binding factor 2 (ILF2)...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29652486/biochemistry-and-molecular-biology-of-flaviviruses
#18
Nicholas J Barrows, Rafael K Campos, Kuo-Chieh Liao, K Reddisiva Prasanth, Ruben Soto-Acosta, Shih-Chia Yeh, Geraldine Schott-Lerner, Julien Pompon, October M Sessions, Shelton S Bradrick, Mariano A Garcia-Blanco
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. Most of these pathogens are transmitted by mosquitos, and not surprisingly, as the earth warms and human populations grow and move, their geographic reach is increasing. Flaviviruses are simple RNA-protein machines that carry out protein synthesis, genome replication, and virion packaging in close association with cellular lipid membranes...
April 13, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29651410/analysis-of-micrornas-expression-profiles-in-madin-darby-bovine-kidney-cells-infected-with-caprine-parainfluenza-virus-type-3
#19
Jizong Li, Li Mao, Wenliang Li, Fei Hao, Chunyan Zhong, Xing Zhu, Xinqin Ji, Leilei Yang, Wenwen Zhang, Maojun Liu, Jieyuan Jiang
Caprine parainfluenza virus type 3 (CPIV3) is a newly emerging pathogenic respiratory agent infecting both young and adult goats, and it was identified in eastern China in 2013. Cellular microRNAs (miRNAs) have been reported to be important modulators of the intricate virus-host interactions. In order to elucidate the role of miRNAs in madin-darby bovine kidney (MDBK) cells during CPIV3 infection. In this study, we performed high-throughput sequencing technology to analyze small RNA libraries in CPIV3-infected and mock-infected MDBK cells...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29651194/river-networks-as-ecological-corridors-a-coherent-ecohydrological-perspective
#20
Andrea Rinaldo, Marino Gatto, Ignacio Rodriguez-Iturbe
This paper draws together several lines of argument to suggest that an ecohydrological framework, i.e. laboratory, field and theoretical approaches focused on hydrologic controls on biota, has contributed substantially to our understanding of the function of river networks as ecological corridors. Such function proves relevant to: the spatial ecology of species; population dynamics and biological invasions; the spread of waterborne disease. As examples, we describe metacommunity predictions of fish diversity patterns in the Mississippi-Missouri basin, geomorphic controls imposed by the fluvial landscape on elevational gradients of species' richness, the zebra mussel invasion of the same Mississippi-Missouri river system, and the spread of proliferative kidney disease in salmonid fish...
February 2018: Advances in Water Resources
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