keyword
MENU ▼
Read by QxMD icon Read
search

Aging and immunity

keyword
https://www.readbyqxmd.com/read/29792776/prevalence-of-inadequate-immunity-to-measles-mumps-rubella-and-varicella-in-mlb-and-nba-athletes
#1
Justin J Conway, Brett G Toresdahl, Daphne I Ling, Nicole T Boniquit, Lisa R Callahan, James J Kinderknecht
BACKGROUND: Multiple outbreaks of vaccine-preventable viral diseases have occurred in professional sports in recent years. Currently, there is no established protocol for vaccination or immunity screening for professional athletes. HYPOTHESIS: There are significant differences in the prevalence of inadequate immunity dependent on age, sport, country of birth, and participation in collegiate sports. STUDY DESIGN: Cross-sectional cohort study...
May 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29792549/analysis-of-the-effects-of-individual-and-community-level-predictors-on-migrant-children-s-primary-immunization-in-yiwu-city-east-china
#2
Yu Hu, Yaping Chen, Liang Hui, Ying Wang
BACKGROUND: To evaluate the effects of a wide range of individual- and community-level factors on migrant children's primary immunization. METHODS: Migrant children aged 13-24 months (born from 1 June 2013 to 31 May 2014) were surveyed in Yiwu city, in June 2015. Social-demographic factors and vaccination records were collected. Five factors at community-level including community wealth, distance to the nearest immunization clinic, maternal education, antenatal clinic (ANC) visits, and hospital delivery were constructed...
May 24, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29792546/application-of-a-mixture-model-to-assess-the-effect-of-measles-mumps-rubella-vaccine-on-the-mumps-epidemic-in-children-from-kindergarten-to-early-school-age-in-jiangsu-province-china
#3
Lei Zhang, Zhiguo Wang, Ying Hu, Xiuying Deng, Hongxiong Guo, Xiang Sun, Fenyang Tang, Minghao Zhou, Yuanbao Liu
A single dose of the measles-mumps-rubella (MMR) vaccine has been applied in routine immunizations for children in China; however, the Immunoglobulin G (IgG) antibody level of mumps in children from kindergarten to early school age with MMR vaccine immunization history has not been elucidated. This study aimed to describe the immunity profile of children from kindergarten to early school age to identify the susceptible population. In Jiangsu Province, a cross-sectional survey of 4- to 8-year-old children who were vaccinated with at least one dose of MMR vaccine was conducted...
May 24, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29791435/immunogenicity-and-efficacy-following-sequential-parenterally-administered-doses-of-salmonella-enteritidis-cops-flic-glycoconjugates-in-infant-and-adult-mice
#4
Scott M Baliban, Brittany Curtis, Deanna Toema, Sharon M Tennant, Myron M Levine, Marcela F Pasetti, Raphael Simon
In sub-Saharan Africa, invasive nontyphoidal Salmonella (iNTS) infections with serovars S. Enteritidis, S. Typhimurium and I 4,[5],12:i:- are widespread in children < 5 years old. Development of an efficacious vaccine would provide an important public health tool to prevent iNTS disease in this population. Glycoconjugates of S. Enteritidis core and O-polysaccharide (COPS) coupled to the homologous serovar phase 1 flagellin protein (FliC) were previously shown to be immunogenic and protected adult mice against death following challenge with a virulent Malian S...
May 23, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29791169/-epicardial-fat-and-osteoprotegerin-does-a-mutual-relation-exist-pilot-study
#5
Markéta Sovová, Eliška Sovová, Jana Zapletalová, Markéta Kaletová, David Stejskal, Milan Sova, Michal Konečný, Vlastimil Procházka, Drahomíra Vrzalová, Lea Zarivnijová
INTRODUCTION: Epicardial fat (EPI) plays important role in development of metabolic and cardiovascular diseases. According to population studies EPI represents independent risk factor of cardiovascular diseases (CVD) and also for neoplasms. Osteoprotegerin (OPG) is a glycoprotein which have role in regulation of immune and cardiovascular systems. High serum levels of OPG are connected with high cardiovascular risk. The aim of our study was to evaluate possible correlation between EPI and OPG level in asymptomatic relatives of patients with CVD...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29790933/the-impact-of-rotavirus-vaccines-on-genotype-diversity-a-comprehensive-analysis-of-2-decades-of-australian-surveillance-data
#6
Susie Roczo-Farkas, Carl D Kirkwood, Daniel Cowley, Graeme L Barnes, Ruth F Bishop, Nada Bogdanovic-Sakran, Karen Boniface, Celeste M Donato, Julie E Bines
Background: Introduction of rotavirus vaccines into national immunization programs (NIPs) could result in strain selection due to vaccine-induced selective pressure. This study describes the distribution and diversity of rotavirus genotypes before and after rotavirus vaccine introduction into the Australian NIP. State-based vaccine selection facilitated a unique comparison of diversity in RotaTeq and Rotarix vaccine states. Methods: From 1995 to 2015, the Australian Rotavirus Surveillance Program conducted genotypic analysis on 13051 rotavirus-positive samples from children <5 years of age, hospitalized with acute gastroenteritis...
May 22, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29790925/effectiveness-of-13-valent-pneumococcal-conjugate-vaccine-against-hospitalization-for-community-acquired-pneumonia-in-older-us-adults-a-test-negative-design
#7
John M McLaughlin, Qin Jiang, Raul E Isturiz, Heather L Sings, David L Swerdlow, Bradford D Gessner, Ruth M Carrico, Paula Peyrani, Timothy L Wiemken, William A Mattingly, Julio A Ramirez, Luis Jodar
Background: Following universal recommendation for use of 13-valent pneumococcal conjugate vaccine (PCV13) in US adults aged ≥65 years in September 2014, we conducted the first real-world evaluation of PCV13 vaccine effectiveness (VE) against hospitalized vaccine-type community-acquired pneumonia (CAP) in this population. Methods: Using a test-negative design, we identified cases and controls from a population-based surveillance study of adults in Louisville, Kentucky, who were hospitalized with CAP...
May 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29789880/distinctive-cd8-t-cell-and-mhc-class-i-signatures-in-polycythemia-vera-patients
#8
Elsa M Cardoso, André J Esgalhado, Luís Patrão, Mónica Santos, Vasco Pinto Neves, Jorge Martinez, Maria Assunção Vaz Patto, Helena Silva, Fernando A Arosa
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by overproduction of red blood cells. We have performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2 m-associated and β2 m-free MHC class I heavy chains, also known as closed and open conformers, respectively, in PV patients and age-matched controls (CTR). We show that the peripheral CD3+ CD8+ T cell pool in PV patients is clearly divided into two discrete populations, a more granular CD3+ CD8high T cell population enriched in effector-memory CD45RA+ T cells (CD8+ TEMRA) when compared to CTR (P < 0...
May 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29789242/-what-have-you-heard-about-the-herd-does-education-about-local-influenza-vaccination-coverage-and-herd-immunity-affect-willingness-to-vaccinate
#9
Jacqueline Logan, Dawn Nederhoff, Brandon Koch, Bridget Griffith, Julian Wolfson, Fareed A Awan, Nicole E Basta
BACKGROUND: Vaccination protects individuals directly and communities indirectly by reducing transmission. We aimed to determine whether information about herd immunity and local vaccination coverage could change an individual's vaccination plans and concern about influenza. METHODS: We surveyed Minnesota residents ≥18 years during the 2016 Minnesota State Fair. Participants were asked to identify the definition of herd immunity, to report their history of and plans to receive influenza vaccine, to report their concern about influenza, and to estimate the reported influenza vaccination coverage in their county...
May 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29789020/influenza-vaccination-of-cancer-patients-during-pd-1-blockade-induces-serological-protection-but-may-raise-the-risk-for-immune-related-adverse-events
#10
Heinz Läubli, Catharina Balmelli, Lukas Kaufmann, Michal Stanczak, Mohammedyaseen Syedbasha, Dominik Vogt, Astrid Hertig, Beat Müller, Oliver Gautschi, Frank Stenner, Alfred Zippelius, Adrian Egli, Sacha I Rothschild
BACKGROUND: Immune checkpoint inhibiting antibodies were introduced into routine clinical practice for cancer patients. Checkpoint blockade has led to durable remissions in some patients, but may also induce immune-related adverse events (irAEs). Lung cancer patients show an increased risk for complications, when infected with influenza viruses. Therefore, vaccination is recommended. However, the efficacy and safety of influenza vaccination during checkpoint blockade and its influence on irAEs is unclear...
May 22, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29788474/umbilical-cord-blood-transplantation-corrects-very-early-onset-inflammatory-bowel-disease-in-chinese-patients-with-il10ra-associated-immune-deficiency
#11
Kaiyue Peng, Xiaowen Qian, Zhiheng Huang, Junping Lu, Yuhuan Wang, Ying Zhou, Huijun Wang, Bingbing Wu, Ying Wang, Lingli Chen, Xiaowen Zhai, Ying Huang
Background: Hematopoietic stem cell transplantation is considered the only curative therapy for very early-onset inflammatory bowel disease with specific immune defects, such as interleukin-10 receptor deficiency. We performed reduced-intensity conditioning before umbilical cord blood transplantation in patients with interleukin-10 receptor-A deficiency. Methods: We enrolled 9 very early-onset inflammatory bowel disease patients with typical manifestations. We diagnosed the patients with interleukin-10 receptor-A deficiency by whole-exome sequencing...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788443/pediatric-infectious-diseases-meets-the-future
#12
Janet R Gilsdorf, Paul Spearman, Janet A Englund, Tina Q Tan, Kristina A Bryant
Pediatric infectious diseases physicians are dedicated to the diagnosis, prevention, and management of infections in children. As such, we play large, and important, roles in the clinical care of children from birth to late adolescence and in infection prevention, antimicrobial stewardship, research pertaining to infections, public health, international and global health, and advocacy for children's health. Furthermore, we are critical to the education of future physicians (in general), pediatricians, and infectious diseases doctors...
May 19, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29788140/immune-unreactive-urinary-albumin-as-a-predictor-of-cardiovascular-events-the-hortega-study
#13
Fernando Martínez, Gernot Pichler, Adrian Ruiz, Juan C Martín-Escudero, Felipe J Chaves, Veronica Gonzalez-Albert, Maria Tellez-Plaza, Hiddo J L Heerspink, Dick D E Zeeuw, Josep Redon
Background: We aimed to determine if immune-unreactive albumin excretion (IURAE) is associated with cardiovascular (CV) events in a representative sample of a general population from Spain. Methods: We included 1297 subjects (mean age ± standard error 48.0 ± 0.2 years, 48% females), who participated in the Hortega Follow-Up Study. The primary endpoint was incidence of fatal and non-fatal CV events. Urinary albumin excretion (UAE) was measured in spot voided urine, frozen at -80°C, by immunonephelometry [immune-reactive albumin excretion (IRAE)] and by high-performance liquid chromatography (HPLC) [total albumin excretion (AE)]...
May 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29786876/temporal-and-long-term-gut-microbiota-variation-in-allergic-disease-a-prospective-study-from-infancy-to-school-age
#14
Kotryna Simonyté Sjödin, Marie-Louise Hammarström, Patrik Rydén, Andreas Sjödin, Olle Hernell, Lars Engstrand, Christina E West
BACKGROUND: Compositional changes of the early life gut microbiota have been implicated in IgE-associated allergic disease but there is lack of longitudinal studies. We examined gut microbiota development from infancy to school age in relation to onset of IgE-associated allergic diseases. At 8 years of age, we also examined the relationship between gut microbiota and T-cell regulation, estimated as responses to polyclonal T-cell activation. METHODS: Stool samples were collected from 93 children at 4, 6 and 13 months, and 8 years of age...
May 22, 2018: Allergy
https://www.readbyqxmd.com/read/29786801/-epilepsy-incidens-prevalens-and-causes
#15
Lars Forsgren, Heléne Sundelin, Olafur Sveinsson
Epilepsy affects people in all ages with the highest incidence in small children, particularly before age one year, and in elderly aged 65 years and older. In Sweden, between 4500-5000 persons develop epilepsy annually. Based on studies from North America and Europe, including the Nordic countries, the number of people with active epilepsy in Sweden is between 60000-70000. The lifetime risk for epilepsy up to age 85 years is 4-5 %, i.e. approximately every 25th person. The new epilepsy classification divides etiology into the following groups: structural, genetic, infectious, metabolic, immune and unknown...
May 21, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29786580/-iron-deficiency-reduces-systemic-inflammation-in-obese-women
#16
Vadim M Nedoborenko, Anna V Lavrenko, Tatyana V Mamontova, Lyudmyla E Vesnina, Igor P Kaidashev
OBJECTIVE: Introduction: Iron plays an important role in the functioning of immunological monitoring due to its stimulating and differentiating effect on the immune system. Obesity is accompanied by chronic low grade inflammation and may be accompanied by a change in the concentration of iron in the blood serum. The aim of the study was to determine the level of systemic inflammation in iron deficiency anemia in patients with obesity. PATIENTS AND METHODS: Materials and methods: 40 women with iron deficiency anemia (30 with obesity and 10 without obesity) and 10 with obesity of a similar age (control group) participated in the study...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786143/impact-of-commensal-flora-on-periodontal-immune-response-to-lipopolysaccharide
#17
Daiki Fukuhara, Koichiro Irie, Yoko Uchida, Kota Kataoka, Kentaro Akiyama, Daisuke Ekuni, Takaaki Tomofuji, Manabu Morita
BACKGROUND: Commensal flora are involved in the appropriate development of the mature immune system. However, it is unclear how commensal flora contribute to immune responses against periodontal pathogens, including the response to lipopolysaccharide (LPS). The purpose of this study was to evaluate the expression of immune responses after topical application of LPS in germ-free (GF) and specific-pathogen-free (SPF) mice. METHODS: GF and SPF mice at 8 weeks of age were randomly divided into four groups each: a baseline group (n = 4/group) and three experimental groups (n = 6/group)...
May 22, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29786142/the-bone-marrow-is-not-only-a-primary-lymphoid-organ-the-critical-role-for-t-lymphocyte-migration-and-housing-of-long-term-memory-plasma-cells
#18
REVIEW
Reinhard Pabst
In immunology and anatomy textbooks the bone marrow is described as a typical "primary lymphoid organ" producing lymphoid cells independent of antigens. The hematopoietic bone marrow is largely age-dependent organ with great anatomical and functional differences among various species. There are estimates that about 12 % of all lymphoid cells in the human body are found in the bone marrow at any given time (2 % in the peripheral blood). Enormous numbers of T lymphocytes migrate to the bone marrow and partly return later to the blood...
May 22, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29786070/selective-elimination-of-senescent-cells-by-mitochondrial-targeting-is-regulated-by-ant2
#19
Sona Hubackova, Eliska Davidova, Katerina Rohlenova, Jan Stursa, Lukas Werner, Ladislav Andera, LanFeng Dong, Mikkel G Terp, Zdenek Hodny, Henrik J Ditzel, Jakub Rohlena, Jiri Neuzil
Cellular senescence is a form of cell cycle arrest that limits the proliferative potential of cells, including tumour cells. However, inability of immune cells to subsequently eliminate senescent cells from the organism may lead to tissue damage, inflammation, enhanced carcinogenesis and development of age-related diseases. We found that the anticancer agent mitochondria-targeted tamoxifen (MitoTam), unlike conventional anticancer agents, kills cancer cells without inducing senescence in vitro and in vivo. Surprisingly, it also selectively eliminates both malignant and non-cancerous senescent cells...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29784862/antibodies-to-icam1-binding-pfemp1-dbl%C3%AE-are-biomarkers-of-protective-immunity-to-malaria-in-a-cohort-of-young-children-from-papua-new-guinea
#20
Sofonias K Tessema, Digjaya Utama, Olga Chesnokov, Anthony N Hodder, Clara S Lin, G L Abby Harrison, Jakob S Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S Hansen, Andrew V Oleinikov, Ivo Mueller, Alyssa E Barry
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to Intercellular Adhesion Molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline antibody levels to the ICAM1-binding PfEMP1 domain, DBLβ3PF11_0521 , in comparison to four control antigens including NTS-DBLα and CIDR1 domains from another group A variant and a group B/C variant...
May 21, 2018: Infection and Immunity
keyword
keyword
22420
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"