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https://www.readbyqxmd.com/read/29443707/pulmonary-impairment-and-risk-assessment-in-a-diacetyl-exposed-population-microwave-popcorn-workers
#1
Robert M Park, Stephen J Gilbert, Christine Whittaker
OBJECTIVES: The butter flavoring additive, diacetyl (DA), can cause bronchiolitis obliterans (BO) by inhalation. A risk assessment was performed using data from a microwave popcorn manufacturing plant. METHODS: Current employees' medical history and pulmonary function tests together with air sampling over a 2.7 yr period were used to analyze FEV1 and FEV1/FVC. The exposure responses for declining pulmonary function and for possible early onset of BO were estimated using multiple regression methods...
February 13, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29438684/post-infectious-bronchiolitis-obliterans-in-children-is-general-quality-of-life-the-right-measure
#2
David Gozal
No abstract text is available yet for this article.
February 10, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29438170/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-dipnech-syndrome-and-carcinoid-tumors-with-without-nech-a-clinicopathologic-radiologic-and-immunomolecular-comparison-study
#3
Maria Cecilia Mengoli, Giulio Rossi, Alberto Cavazza, Renato Franco, Federica Zito Marino, Mario Migaldi, Letizia Gnetti, Enrico Maria Silini, Luca Ampollini, Marcello Tiseo, Filippo Lococo, Ludovic Fournel, Paolo Spagnolo, Vincent Cottin, Thomas V Colby
The diagnostic criteria of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) are not well defined, and DIPNECH can be mistaken for carcinoids associated with neuroendocrine cell hyperplasia (NECH). In this study, we compared clinical, radiologic, histologic, immunohistochemical, and molecular features of DIPNECH and isolated carcinoids with/without NECH. The study population included 151 cases (77 female patients and 74 male patients), 19 with DIPNECH and 132 with carcinoids with/without NECH...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29436781/rsv-prophylaxis-guideline-changes-and-outcomes-in-children-with-congenital-heart-disease
#4
Adam S Walpert, Ian D Thomas, Merlin C Lowe, Michael D Seckeler
OBJECTIVE: The aim of this study was to compare inpatient outcomes and costs for children with respiratory syncytial virus and congenital heart disease before and after the change in management guidelines for respiratory syncytial virus prophylaxis. DESIGN: Hospital discharge data from the Vizient (formerly University HealthSystem Consortium) were queried from October 2012 to June 2014 (Era 1) and July 2014 to April 2016 (Era 2) for patients aged <24 months with an any International Classification of Disease (ICD)-9 or ICD-10 code for congenital heart disease (745-747...
February 13, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29433429/the-management-of-children-with-bronchiolitis-in-the-australasian-hospital-setting-development-of-a-clinical-practice-guideline
#5
Sharon O'Brien, Sally Wilson, Fenella J Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley, Stuart R Dalziel
BACKGROUND: Bronchiolitis is the commonest respiratory infection in children less than 12 months and cause of hospitalisation in infants under 6 months of age in Australasia. Unfortunately there is substantial variation in management, despite high levels of supporting evidence. This paper reports on the process, strengths and challenges of the hybrid approach used to develop the first Australasian management guideline relevant to the local population. METHOD: An adaption of the nine steps recommended by the National Health and Medical Research Council (NHMRC) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology were utilised...
February 12, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29430425/clinical-outcomes-of-lung-transplantation-experience-at-asan-medical-center
#6
Yong Ho Jeong, Sehoon Choi, Seung-Il Park, Dong Kwan Kim
Background: Lung transplantation is a life-saving procedure in patients with end-stage lung disease, and is increasingly performed in Korea. Methods: We retrospectively evaluated the outcomes of patients who received a lung transplant at Asan Medical Center between January 2008 and December 2016. Thirteen of 54 patients experienced multiorgan transplantation; the remaining 41 who received only lung grafts were included. Results: The mean age of the lung transplant recipients was 44...
February 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29424432/human-metapneumovirus-in-hospitalized-children-less-than-five-years-of-age-in-pakistan
#7
Mohammad Tahir Yousafzai, Romesa Ibrahim, Rozina Thobani, Fatima Aziz, Asad Ali
BACKGROUND: Acute respiratory infection (ARI) is the second leading cause of death in children less than five years of age worldwide. Human Metapneumovirus (hMPV) is associated with around 5-7% of the total pneumonia admissions in children. The aim of this study was to determine the magnitude of hMPV associated hospitalizations among children, in Karachi, Pakistan. METHODOLOGY: A three years prospective study was conducted at the Aga Khan University Hospital (AKUH), from August 2009 to June 2012...
February 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29422903/autoantibodies-in-chronic-obstructive-pulmonary-disease
#8
REVIEW
Lifang Wen, Susanne Krauss-Etschmann, Frank Petersen, Xinhua Yu
Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death worldwide, is characterized by irreversible airflow limitation based on obstructive bronchiolitis, emphysema, and chronic pulmonary inflammation. Inhaled toxic gases and particles, e.g., cigarette smoke, are major etiologic factors for COPD, while the pathogenesis of the disease is only partially understood. Over the past decade, an increasing body of evidence has been accumulated for a link between COPD and autoimmunity. Studies with clinical samples have demonstrated that autoantibodies are present in sera of COPD patients and some of these antibodies correlate with specific disease phenotypes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29417689/efficacy-of-high-dose-steroids-for-bronchiolitis-obliterans-syndrome-post-pediatric-hematopoietic-stem-cell-transplantation
#9
Ehud Even-Or, Hasan Ghandourah, Muhammad Ali, Joerg Krueger, Neil B Sweezey, Tal Schechter
BOS is the pulmonary manifestation of cGvHD post-allogeneic HSCT. Survival and treatment of this often fatal complication have not improved over the last 20 years and there is no clear standard of care. For the past 10 years, BOS was treated in our center with monthly cycles of HDPS. We reviewed the outcomes of patients with post-HSCT BOS who met the diagnostic criteria for BOS as per the NIH consensus and were treated with at least one cycle of methylprednisolone at a dose of 10-30 mg/kg/d×3 d. We collected demographic and clinical data, responses to treatment and results of pulmonary function tests at several time points...
February 7, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29412352/angiostrongylus-spp-in-the-americas-geographical-and-chronological-distribution-of-definitive-hosts-versus-disease-reports
#10
Romina Valente, Maria Del Rosario Robles, Graciela T Navone, Julia I Diaz
BACKGROUND: Angiostrongyliasis is an infection caused by nematode worms of the genus Angiostrongylus. The adult worms inhabit the pulmonary arteries, heart, bronchioles of the lung, or mesenteric arteries of the caecum of definitive host. Of a total of 23 species of Angiostrongylus cited worldwide, only nine were registered in the American Continent. Two species, A. cantonensis and A. costaricensis, are considered zoonoses when the larvae accidentally parasitise man. OBJECTIVES: In the present study, geographical and chronological distribution of definitive hosts of Angiostrongylus in the Americas is analysed in order to observe their relationship with disease reports...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29410056/evaluation-of-monoclonal-antibodies-that-detect-conserved-proteins-from-respiratory-syncytial-virus-metapneumovirus-and-adenovirus-in-human-samples
#11
Liliana A González, Yaneisi Vázquez, Jorge E Mora, Christian E Palavecino, Pablo Bertrand, Marcela Ferrés, Ana M Contreras, Andrea A Beckhaus, Claudia A Riedel, Susan M Bueno
Human Respiratory Syncytial Virus (hRSV), human Metapneumovirus (hMPV) and Adenovirus (ADV), are three of the most prevalent viruses responsible for pneumonia and bronchiolitis in children and elderly worldwide, accounting for a high number of hospitalizations annually. Diagnosis of these viruses is required to take clinical actions that allow an appropriate patient management. Thereby, new strategies to design fast diagnostic methods are highly required. In the present work, six monoclonal antibodies (mAbs, two for each virus) specific for conserved proteins from hRSV, hMPV and ADV were generated and evaluated through different immunological techniques, based on detection of purified protein, viral particles and human samples...
January 31, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29406777/evaluating-for-bronchiolitis-obliterans-with-low-attenuation-ct-3d-reconstructions
#12
Deborah R Liptzin, Emily M DeBoer, Roger H Giller, Miranda E Kroehl, Jason P Weinman
No abstract text is available yet for this article.
February 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29402263/effect-of-the-2015-earthquake-on-pediatric-inpatient-pattern-at-a-tertiary-care-hospital-in-nepal
#13
Bishnu Rath Giri, Ram Hari Chapagain, Samana Sharma, Sandeep Shrestha, Sunita Ghimire, P Ravi Shankar
BACKGROUND: Earthquakes impact child health in many ways. Diseases occurring immediately following an earthquake have been studied in field based hospitals but studies on the inpatient disease pattern among children without trauma in a permanent hospital setup is lacking. METHODS: We examined the diagnoses of all children without trauma, admitted to Kanti Children's Hospital, Kathmandu for fifteen-week duration (from 4th week to end of the 18th week) following the 7...
February 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29401325/safety-and-immunogenicity-of-3-formulations-of-an-investigational-respiratory-syncytial-virus-vaccine-in-non-pregnant-women-results-from-two-phase-ii-trials
#14
Jiri Beran, Jason D Lickliter, Tino F Schwarz, Casey Johnson, Laurence Chu, Joseph B Domachowske, Pierre Van Damme, Kanchanamala Withanage, Laurence A Fissette, Marie-Pierre David, Koen Maleux, Alexander C Schmidt, Marta Picciolato, Ilse Dieussaert
Background: Respiratory syncytial virus (RSV) causes bronchiolitis and pneumonia in neonates and infants. RSV vaccination during pregnancy could boost pre-existing neutralizing antibody titers, providing passive protection to newborns. Methods: Two observer-blind, controlled studies (RSV F-020 [NCT02360475], RSV F-024 [NCT02753413]) evaluated immunogenicity and safety of an investigational RSV vaccine in healthy, non-pregnant 18-45-year-old women. Both studies used licensed Tdap vaccine as control...
February 1, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29397088/management-of-acute-cough-by-zataria-multiflora-boiss-as-an-alternative-treatment
#15
REVIEW
Mohaddese Mahboubi
Cough, as a defensive reflux mechanism, removes foreign objects and secretions from bronchi and bronchioles of airways. Zataria multiflora is a popular plant for treatment of cough in Iranian traditional medicine. The aim of this review was to evaluate the potency of Z. multiflora as an alternative treatment in management of acute cough and its possible mechanisms of action. Here the authors compiled information about Z. multiflora in the treatment of cough from all accessible resources and books. The results of this investigation showed that there were five clinical studies that evaluated the efficacy of Z...
January 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29395853/bronchiolitis-obliterans-organizing-pneumonia-after-stereotactic-ablative-radiation-therapy-for-lung-cancer-a-case-report
#16
G Fanetti, F Bazzani, A Ferrari, D Alterio, S M Donghi, F A Pounou Kamga, R Orecchia, B A Jereczek-Fossa
Bronchiolitis obliterans organizing pneumonia is an interstitial lung disease rarely occurring after radiotherapy probably due to an activation of autoimmune processes. Most cases have been described after postoperative radiotherapy for breast cancer. Corticosteroids represent the main treatment, prognosis is generally favorable. We described a case of bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for a recurrent lung cancer. Antibiotics and steroids were administered to solve the clinical picture...
January 26, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29394414/ultrafine-particulate-matter-combined-with-ozone-exacerbates-lung-injury-in-mature-adult-rats-with-cardiovascular-disease
#17
Emily M Wong, William F Walby, Dennis W Wilson, Fern Tablin, Edward S Schelegle
BACKGROUND: Particulate matter (PM) and ozone (O3) are dominant air pollutants that contribute to development and exacerbation of multiple cardiopulmonary diseases. Mature adults with cardiovascular disease (CVD) are particularly susceptible to air pollution-related cardiopulmonary morbidities and mortalities. OBJECTIVES: The aim was to investigate the biologic potency of ultrafine particulate matter (UFPM) combined with O3 in the lungs of mature adult normotensive and spontaneously hypertensive Wistar-Kyoto rats...
January 31, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29394301/issues-identified-by-postdischarge-contact-after-pediatric-hospitalization-a-multisite-study
#18
Kris P Rehm, Mark S Brittan, John R Stephens, Pradeep Mummidi, Michael J Steiner, James C Gay, Soleh Al Ayubi, Nitin Gujral, Vandna Mittal, Kelly Dunn, Vincent Chiang, Matt Hall, Kevin Blaine, Margaret O'Neill, Sarah McBride, Jayne Rogers, Jay G Berry
BACKGROUND: Many hospitals are considering contacting hospitalized patients soon after discharge to help with issues that arise. OBJECTIVE: To (1) describe the prevalence of contactidentified postdischarge issues (PDI) and (2) assess characteristics of children with the highest likelihood of having a PDI. DESIGN, SETTING, PATIENTS: A retrospective analysis of hospital-initiated follow-up contact for 12,986 children discharged from January 2012 to July 2015 from 4 US children's hospitals...
February 2, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29394172/the-emerging-spectrum-of-exposure-related-bronchiolitis
#19
Silpa D Krefft, Carlyne D Cool, Cecile S Rose
PURPOSE OF REVIEW: Exposure-related bronchiolitis is increasingly recognized as an important but challenging clinical diagnosis. Acute and chronic inhalational exposures are associated with variable clinical presentations and a spectrum of histopathologic abnormalities affecting the small airways. This review provides an overview of the histologic patterns and occupational settings for exposure-related bronchiolitis, along with recent advances in disease diagnosis and management. RECENT FINDINGS: The entire histopathologic spectrum of bronchiolitis (constrictive, obliterative, proliferative, lymphocytic, respiratory) has been reported in exposure-related bronchiolitis...
February 1, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29389687/tocilizumab-cannot-prevent-the-development-of-bronchiolitis-obliterans-in-patients-with-castleman-disease-associated-paraneoplastic-pemphigus
#20
Liyang Gu, Shuang Ye
No abstract text is available yet for this article.
February 1, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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