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https://www.readbyqxmd.com/read/28328090/bronchiolitis-score-of-sant-joan-de-d%C3%A3-u-brosjod-score-validation-and-usefulness
#1
Mònica Balaguer, Carme Alejandre, David Vila, Elisabeth Esteban, Josep L Carrasco, Francisco José Cambra, Iolanda Jordan
OBJECTIVE: To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff. PATIENTS AND METHODS: Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed using Cronbach's α. To determine inter-rater reliability, the concordance correlation coefficient estimated as an intraclass correlation coefficient (CCC) and limits of agreement estimated as the 90% total deviation index (TDI) were estimated...
April 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28325776/noninvasive-respiratory-support-during-pediatric-ground-transport-implementation-of-a-safe-and-feasible-procedure
#2
Nuria Millán, Carme Alejandre, Aina Martinez-Planas, Josep Caritg, Elisabeth Esteban, Martí Pons-Òdena
BACKGROUND: The purpose of this work was to determine the safety and feasibility of noninvasive support in children with acute respiratory failure (ARF) during interhospital ground transport. METHODS: This was a prospective, single-center observational clinical study in the pediatric transport unit of a tertiary-care pediatric hospital. We included all subjects with ARF transported from November 2010 to March 2013. A specific noninvasive support protocol was used for all cases...
March 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28320035/srage-is-elevated-in-the-lungs-of-premature-infants-receiving-mechanical-ventilation
#3
Henry J Rozycki, Jennifer Bradley, Simon Karam
Background Soluble receptor for advanced glycation end-products (sRAGE), a soluble isoform of the RAGE receptor, is elevated in lungs from patients with acute conditions such as acute respiratory distress syndrome and bronchiolitis. This study investigated whether sRAGE is present in ventilated infants. Methods Tracheal aspirates from the first week or the fifth week of life were obtained from intubated very low birth weight subjects and analyzed by Western blot. Immunohistochemistry analysis for sRAGE was performed on paraffin-embedded lung autopsy slides from 19 other infants...
March 20, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28314803/omega-3-polyunsaturated-fatty-acids-accelerate-airway-repair-by-activating-ffa4-in-club-cells
#4
Kyoung-Pil Lee, Soo-Jin Park, Saeromi Kang, Jung-Min Koh, Koichi Sato, Hae Young Chung, Fumikazu Okajima, Dong-Soon Im
A GPCR named FFA4 (also known as GPR120) was found to act as a GPCR for omega-3 polyunsaturated fatty acids. Its expression has been reported in lung epithelial club cells. The authors investigated whether supplementation of the omega-3 fatty acids benefits lung health. Omacor® (7.75 mg kg-1), clinically prescribed preparation of omega-3 fatty acids and FFA4-knockout mice were utilized in a naphthalene-induced mouse model of acute airway injury (one injection of 30 mg kg-1, i.p.). Naphthalene injection induced complete destruction of bronchiolar epithelial cells within a day...
March 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28306146/the-relationship-between-nasopharyngeal-ccl5-and-microbiota-on-disease-severity-among-infants-with-bronchiolitis
#5
Kohei Hasegawa, Jonathan M Mansbach, Nadim J Ajami, Joseph F Petrosino, Robert J Freishtat, Stephen J Teach, Pedro A Piedra, Carlos A Camargo
Emerging evidence suggests that the airway microbiota plays an important role in viral bronchiolitis pathobiology. However, little is known about the combined role of airway microbiota and CCL5 in infants with bronchiolitis. In this multicenter prospective cohort study of 1,005 infants (age <1 year) hospitalized for bronchiolitis during 2011-2014, we observed statistically-significant interactions between nasopharyngeal airway CCL5 levels and microbiota profiles with regard to the risk of both intensive care use (Pinteraction =0...
March 17, 2017: Allergy
https://www.readbyqxmd.com/read/28301570/human-metapnuemovirus-infections-in-hospitalized-children-and-comparison-with-other-respiratory-viruses-2005-2014-prospective-study
#6
María Luz García-García, Cristina Calvo, Cristina Rey, Beatriz Díaz, Maria Del Mar Molinero, Francisco Pozo, Inmaculada Casas
BACKGROUND: Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV infections with respiratory syncytial virus (HRSV), rhinovirus (HRV), adenovirus and human bocavirus infections in the same population...
2017: PloS One
https://www.readbyqxmd.com/read/28299359/aifm1-mutation-presenting-with-fatal-encephalomyopathy-and-mitochondrial-disease-in-an-infant
#7
Sarah U Morton, Sanjay P Prabhu, Hart G W Lidov, Jiahai Shi, Irina Anselm, Catherine A Brownstein, Matthew N Bainbridge, Alan H Beggs, Sara O Vargas, Pankaj B Agrawal
Apoptosis-inducing factor mitochondrion-associated 1 (AIFM1), encoded by the gene AIFM1, has roles in electron transport, apoptosis, ferredoxin metabolism, reactive oxygen species generation, and immune system regulation. Here we describe a patient with a novel AIFM1 variant presenting unusually early in life with mitochondrial disease, rapid deterioration, and death. Autopsy, at the age of 4 mo, revealed features of mitochondrial encephalopathy, myopathy, and involvement of peripheral nerves with axonal degeneration...
March 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28296181/-white-out-after-lung-transplantation-a-multicentre-cohort-description-of-late-acute-graft-failure
#8
Stijn E Verleden, Jens Gottlieb, Adriana Dubbeldam, Geert M Verleden, Hendrik Suhling, Tobias Welte, Robin Vos, Mark Greer
Graft failure represents a leading cause of mortality following organ transplantation. Acute late-onset graft failure has not been widely reported. This paper describes the demographics, CT imaging pathology findings and treatment of patients presenting with the latter. A retrospective review of lung transplant recipients at 2 large-volume centres was performed. Acute late-onset graft failure was defined as sudden onset of bilateral infiltrates with an oxygenation index <200 without identifiable cause or concurrent extra-pulmonary organ failure...
March 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28292850/clinical-outcomes-of-bronchiolitis-after-implementation-of-a-general-ward-high-flow-nasal-cannula-guideline
#9
Jeffrey Riese, Timothy Porter, Jamie Fierce, Alison Riese, Troy Richardson, Brian K Alverson
OBJECTIVE: The goal of this study was to assess the association of the introduction of a ward's high-flow nasal cannula (HFNC) guideline with clinical outcomes of infants with bronchiolitis. METHODS: We conducted a retrospective, pre-post intervention study with an interrupted time series analysis of infants admitted with bronchiolitis between 2010 and 2014 at an urban, tertiary care children's hospital. Patients admitted in the 24 months before and after initiation of a guideline for HFNC use on the general wards were compared...
March 14, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28292849/chasing-the-latest-rabbit-high-flow-nasal-cannula-and-bronchiolitis
#10
Brent A Mothner, Ricardo A Quinonez
No abstract text is available yet for this article.
March 14, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28286262/intravenous-magnesium-sulfate-for-bronchiolitis-a-randomized-trial
#11
Khalid Alansari, Rafah Sayyed, Bruce L Davidson, Shahaza Al Jawala, Mohamed Ghadier
BACKGROUND: To determine if intravenous magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in bronchiolitis patients when added to supportive care METHODS: We compared a single dose of 100 mg/kg intravenous magnesium sulfate versus placebo for acute bronchiolitis. Patients received bronchodilator therapy, nebulized hypertonic saline, and 5 days of dexamethasone if there was eczema and/or a family history of asthma. Time to medical readiness for discharge was the primary efficacy outcome...
March 9, 2017: Chest
https://www.readbyqxmd.com/read/28285184/the-impact-of-temperature-and-relative-humidity-on-spatiotemporal-patterns-of-infant-bronchiolitis-epidemics-in-the-contiguous-united-states
#12
Chantel Sloan, Matthew Heaton, Sorah Kang, Candace Berrett, Pingsheng Wu, Tebeb Gebretsadik, Nicholas Sicignano, Amber Evans, Rees Lee, Tina Hartert
Infant bronchiolitis is primarily due to infection by respiratory syncytial virus (RSV), which is highly seasonal. The goal of the study is to understand how circulation of RSV is impacted by fluctuations in temperature and humidity in order to inform prevention efforts. Using data from the Military Health System (MHS) Data Repository (MDR), we calculated rates of infant bronchiolitis for the contiguous US from July 2004 to June 2013. Monthly temperature and relative humidity were extracted from the National Climate Data Center...
March 9, 2017: Health & Place
https://www.readbyqxmd.com/read/28284475/morning-salivary-cortisol-in-young-children-reference-values-and-the-effects-of-age-sex-and-acute-bronchiolitis
#13
Leif Bjarte Rolfsjord, Egil Bakkeheim, Teresa Løvold Berents, Johan Alm, Håvard Ove Skjerven, Kai-Håkon Carlsen, Petter Mowinckel, Ann-Christine Sjöbeck, Karin Cecilie Lødrup Carlsen
OBJECTIVE: To identify morning salivary cortisol reference values in infancy and at 2 years of age and to investigate the influence of age, sex and acute bronchiolitis. STUDY DESIGN: In this South-East Norwegian cohort study, 308 children hospitalized with moderate to severe acute bronchiolitis in infancy in 2010-2011 were compared with 223 healthy controls included in 2012 by measuring morning salivary cortisol levels at inclusion and at 2 years of age. Samples were collected shortly after awakening after 6 am...
March 8, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28273842/immunological-features-of-respiratory-syncytial-virus-caused-pneumonia-implications-for-vaccine-design
#14
REVIEW
Emma Rey-Jurado, Alexis M Kalergis
The human respiratory syncytial virus (hRSV) is the causative agent for high rates of hospitalizations due to viral bronchiolitis and pneumonia worldwide. Such a disease is characterized by an infection of epithelial cells of the distal airways that leads to inflammation and subsequently to respiratory failure. Upon infection, different pattern recognition receptors recognize the virus and trigger the innate immune response against the hRSV. Further, T cell immunity plays an important role for virus clearance...
March 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28273385/effect-of-aerosolized-antipseudomonals-on-pseudomonas-positivity-and-bronchiolitis-obliterans-syndrome-after-lung-transplantation
#15
Cody A Moore, Joseph M Pilewski, Raman Venkataraman, Keven M Robinson, Matthew R Morrell, Stephen R Wisniewski, Adriana Zeevi, John F McDyer, Christopher R Ensor
PURPOSE: To describe the effects of aerosolized antipseudomonals (AAP) on Pseudomonas (PS) culture positivity, bronchiolitis obliterans syndrome (BOS), and acute cellular rejection (ACR) in lung transplant recipients (LTRs). METHODS: Single-center, retrospective cohort study of adult LTRs treated with either AAP for ≥28 days vs no AAP therapy or AAP therapy <28 days, indexed to a matched median date post lung transplantation (LT). Primary outcome was freedom from PS positivity by positive bronchoalveolar lavage (BAL) or bronchial wash at 1 year...
March 8, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28272490/distribution-analysis-via-mass-spectrometry-imaging-of-ephedrine-in-the-lungs-of-rats-orally-administered-the-japanese-kampo-medicine-maoto
#16
Takashi Matsumoto, Hirotaka Kushida, Shoko Matsushita, Yoshiyuki Oyama, Takafumi Suda, Junko Watanabe, Yoshio Kase, Mitsutoshi Setou
Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine (EPD), the main ingredient in maoto, is also clinically used to treat respiratory diseases. However, the pharmacokinetics and distribution of EPD in the lungs after the administration of maoto have not been demonstrated. This study aimed to determine the concentrations, distribution, and pharmacokinetics of EPD and its precursor methylephedrine (MEPD) in the lungs of rats orally administered maoto (1 and 4 g/kg)...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28269092/detection-of-crackle-events-using-a-multi-feature-approach
#17
L Mendes, I M Vogiatzis, E Perantoni, E Kaimakamis, I Chouvarda, N Maglaveras, J Henriques, P Carvalho, R P Paiva
The automatic detection of adventitious lung sounds is a valuable tool to monitor respiratory diseases like chronic obstructive pulmonary disease. Crackles are adventitious and explosive respiratory sounds that are usually associated with the inflammation or infection of the small bronchi, bronchioles and alveoli. In this study a multi-feature approach is proposed for the detection of events, in the frame space, that contain one or more crackles. The performance of thirty-five features was tested. These features include thirty-one features usually used in the context of Music Information Retrieval, a wavelet based feature as well as the Teager energy and the entropy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268160/primary-sj%C3%A3-gren-s-syndrome-and-bronchiolitis-an-unusual-association
#18
Lourdes Medina-Paz, José Luis Che-Morales, Hirian Alonso Moshe Barrera-Pérez, Arturo Cortes-Telles
Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects the exocrine glands. It has been reported that the association between SS and respiratory involvement occurs in 11% and 45% of cases, and can be the initial manifestation of the disease. The diagnosis is based on the integration of clinical, immunological and histopathological criteria. This paper examines a 58-year-old man with SS, severe dyspnea and recurrent exacerbations associated with bronchiolitis-bronchiectasis. The absence of anti-Ro and anti-La antibodies associated with severe bronchiolitis is a clinical presentation that is poorly characterized in this group of patients; moreover, how to treat them remains unclear...
March 3, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28267794/the-interdependencies-of-viral-load-the-innate-immune-response-and-clinical-outcome-in-children-presenting-to-the-emergency-department-with-respiratory-syncytial-virus-associated-bronchiolitis
#19
Felipe-Andrés Piedra, Minghua Mei, Vasanthi Avadhanula, Reena Mehta, Letisha Aideyan, Roberto P Garofalo, Pedro A Piedra
Respiratory syncytial virus (RSV) causes significant infant morbidity and mortality. For decades severe RSV-induced disease was thought to result from an uncontrolled host response to viral replication, but recent work suggests that a strong innate immune response early in infection is protective. To shed light on host-virus interactions and the viral determinants of disease, copy numbers of five RSV genes (NS1, NS2, N, G, F) were measured by quantitative real-time polymerase chain reaction (qPCR) in nasal wash samples from children with RSV-associated bronchiolitis...
2017: PloS One
https://www.readbyqxmd.com/read/28267558/rapid-detection-of-donor-cell-free-dna-in-lung-transplant-recipients-with-rejections-using-donor-recipient-hla-mismatch
#20
Jun Zou, Brian Duffy, Michael Slade, Andrew Lee Young, Nancy Steward, Ramsey Hachem, T Mohanakumar
Fiberoptic bronchoscopy and transbronchial lung biopsy are currently the gold standard for detection of acute rejection following human lung transplantation (LTx). However, these surveillance procedures are expensive and invasive. Up to now, there are few new methods that have demonstrated clinical utility for detecting early stages of rejection following human lung transplantation. We optimized and technically validated a novel method to quantify donor-derived circulating cell free DNA (DcfDNA) that can be used as an early biomarker for lung allograft rejection...
March 4, 2017: Human Immunology
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