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https://www.readbyqxmd.com/read/27899097/antinociception-of-petroleum-ether-fraction-derived-from-crude-methanol-extract-of-melastoma-malabathricum-leaves-and-its-possible-mechanisms-of-action-in-animal-models
#1
Z A Zakaria, E S Jaios, M H Omar, S Abd Rahman, S S A Hamid, S M Ching, L K Teh, M Z Salleh, S Deny, M Taher
BACKGROUND: Melastoma malabathricum L. (family Melastomaceae) has been traditionally used as remedies against various ailments including those related to pain. The methanol extract of M. malabathricum leaves has been proven to show antinociceptive activity. Thus, the present study aimed to determine the most effective fraction among the petroleum ether- (PEMM), ethyl acetate- (EAMM) and aqueous- (AQMM) fractions obtained through successive fractionation of crude, dried methanol extract of M...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27886112/synthesis-characterization-and-anti-inflammatory-activities-of-methyl-salicylate-derivatives-bearing-piperazine-moiety
#2
Jingfen Li, Yong Yin, Lisheng Wang, Pengyun Liang, Menghua Li, Xu Liu, Lichuan Wu, Hua Yang
In this study, a new series of 16 methyl salicylate derivatives bearing a piperazine moiety were synthesized and characterized. The in vivo anti-inflammatory activities of target compounds were investigated against xylol-induced ear edema and carrageenan-induced paw edema in mice. The results showed that all synthesized compounds exhibited potent anti-inflammatory activities. Especially, the anti-inflammatory activities of compounds M15 and M16 were higher than that of aspirin and even equal to that of indomethacin at the same dose...
November 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27781667/peripheral-snap-fit-locking-mechanisms-and-smooth-surface-finish-of-tibial-trays-reduce-backside-wear-in-fixed-bearing-total-knee-arthroplasty
#3
Łukasz Łapaj, Adrian Mróz, Paweł Kokoszka, Jacek Markuszewski, Justyna Wendland, Celina Helak-Łapaj, Jacek Kruczyński
Background and purpose - Severe backside wear, observed in older generations of total knee replacements (TKRs), led to redesign of locking mechanisms to reduce micromotions between tibial tray and inlay. Since little is known about whether this effectively reduces backside wear in modern designs, we examined backside damage in retrievals of various contemporary fixed-bearing TKRs. Patients and methods - A consecutive series of 102 inlays with a peripheral (Stryker Triathlon, Stryker Scorpio, DePuy PFC Sigma, Aesculap Search Evolution) or dovetail locking mechanism (Zimmer NexGen, Smith and Nephew Genesis II) was examined...
October 26, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27730265/retreat-and-extinction-of-the-late-pleistocene-cave-bear-ursus-spelaeus-sensu-lato
#4
Mateusz Baca, Danijela Popović, Krzysztof Stefaniak, Adrian Marciszak, Mikołaj Urbanowski, Adam Nadachowski, Paweł Mackiewicz
The cave bear (Ursus spelaeus sensu lato) is a typical representative of Pleistocene megafauna which became extinct at the end of the Last Glacial. Detailed knowledge of cave bear extinction could explain this spectacular ecological transformation. The paper provides a report on the youngest remains of the cave bear dated to 20,930 ± 140 (14)C years before present (BP). Ancient DNA analyses proved its affiliation to the Ursus ingressus haplotype. Using this record and 205 other dates, we determined, following eight approaches, the extinction time of this mammal at 26,100-24,300 cal...
December 2016: Die Naturwissenschaften
https://www.readbyqxmd.com/read/27595449/antibodies-to-hbv-surface-antigen-in-relation-to-interferon-%C3%AE-3-in-hemodialysis-patients
#5
Alicja E Grzegorzewska, Monika K Świderska, Adrianna Mostowska, Wojciech Warchoł, Paweł P Jagodziński
AIM: To investigate circulating IFN-λ3 and IFNL3 polymorphisms in hemodialysis (HD) patients differing in HBV surface antigen antibody (anti-HBs) production. METHODS: The study included 106 HBV-vaccinated HD patients (88 developed anti-HBs) and 36 HBV-infected HD subjects (27 developed anti-HBs). Plasma IFN-λ3 (enzyme-linked immunosorbent assay) and rs12979860 (C>T) and rs8099917 (T>G) in IFNL3 (high-resolution melting curve analysis) were analyzed with regard to the association with anti-HBs production in response to HBV vaccination or infection...
September 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27592511/cancer-pain-relief-achieved-by-disrupting-tumor-driven-semaphorin-3a-signaling-in-mice
#6
Takehiko Maeda, Daisuke Yamada, Kohichi Kawahara
Cancer-induced bone pain (CIBP) is the most common pain arising from cancer and is inadequately managed with current standard therapeutics. While the etiology of CIBP remains to be fully elucidated, increasing evidence suggests that CIBP is uniquely complex. We tested whether semaphorin 3A (Sema3A) signals were involved in the development of CIBP in mice. The mouse model employed for CIBP - mice inoculated with Lewis lung carcinoma (LLC) cells injected into the femur intramedullary space - showed progressive decline in the weight bearing of the ipsilateral hind limb...
October 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27543078/family-planning-knowledge-attitudes-and-practices-in-refugee-and-migrant-pregnant-and-post-partum-women-on-the-thailand-myanmar-border-a-mixed-methods-study
#7
Patricia Salisbury, Layla Hall, Sibylla Kulkus, Moo Kho Paw, Nay Win Tun, Aung Myat Min, Kesinee Chotivanich, Somjet Srikanok, Pranee Ontuwong, Supachai Sirinonthachai, François Nosten, Shawn Somerset, Rose McGready
BACKGROUND: Lack of data in marginalized populations on knowledge, attitudes and practices (KAP) hampers efforts to improve modern contraceptive practice. A mixed methods study to better understand family planning KAP amongst refugee and migrant women on the Thailand-Myanmar border was conducted as part of an ongoing effort to improve reproductive health, particularly maternal mortality, through Shoklo Malaria Research Unit (SMRU) antenatal and birthing services. METHODS: Cross-sectional surveys and focus group discussions (FGDs) in currently pregnant women; and in-depth interviews (IDIs) in selected post-partum women with three children or more; were conducted...
2016: Reproductive Health
https://www.readbyqxmd.com/read/27501482/robust-anti-nociceptive-effects-of-monoacylglycerol-lipase-inhibition-in-a-model-of-osteoarthritis-pain
#8
James J Burston, Paul I Mapp, Sarir Sarmad, David A Barrett, Micah J Niphakis, Benjamin F Cravatt, David A Walsh, Victoria Chapman
BACKGROUND AND PURPOSE: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain relief. We evaluated the effects of a potent and selective monoacylglycerol (MAG) lipase inhibitor (MJN110) on OA pain behaviour, spinal mechanisms of action and joint histopathology in the rat. EXPERIMENTAL APPROACH: Intra-articular injection of monosodium iodoacetate (MIA) models OA pain and mimics clinical joint pathology...
November 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27448444/accumulating-nanoparticles-by-epr-a-route-of-no-return
#9
Romeo Ngoune, Annette Peters, Dominik von Elverfeldt, Karl Winkler, Gerhard Pütz
Nanoparticle-based drug delivery to ease anticancer therapy relies primarily on the enhanced permeability and retention effect (EPR). The leaky vascular structure in tumors allows extravasation of nanoparticles, often termed passive targeting. Long term retention of nanoparticles is attributed to the lack of lymphatic drainage, and unidirectional extravasation has been implied. Fluorescent liposomes with a plasma half-life of 29h were injected into tumor-bearing rats, and biodistribution in tumor, skin, paws and ears was monitored via in vivo fluorescence measurements...
September 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27394749/taxonomy-of-euconnus-complex-part-viii-subgenera-napoconnus-%C3%A2-himaloconnus-and-nepaloconnus-removed-from-euconnus-br-coleoptera-staphylinidae-scydmaeninae
#10
Paweł Jałoszyński
Examination of the type species of Napoconnus, Himaloconnus and Nepaloconnus, taxa previously placed as subgenera of Euconnus, revealed characters remarkably different from those diagnostic for Euconnus. Napoconnus and Himaloconnus have narrowly separated metacoxae, with the metaventral intercoxal process bearing a pair of long and pointed spines touching at middle; this character alone excludes these taxa from Euconnus. Consequently, Napoconnus and Himaloconnus are elevated to the genus rank and redefined...
2016: Zootaxa
https://www.readbyqxmd.com/read/27345362/calcitonin-attenuates-cartilage-degeneration-and-nociception-in-an-experimental-rat-model-of-osteoarthritis-role-of-tgf-%C3%AE-in-chondrocytes
#11
Zhi-Hong Wen, Chi-Chieh Tang, Yi-Chen Chang, Shi-Ying Huang, Yen-You Lin, Shih-Peng Hsieh, Hsin-Pai Lee, Sung-Chun Lin, Wu-Fu Chen, Yen-Hsuan Jean
We investigated the role of the calcitonin (Miacalcin) in the progression of osteoarthritis (OA) and in nociceptive behavior in an experimental rat model of OA and osteoporosis. OA was induced by anterior cruciate ligament transection (ACLT) of the right knee and by bilateral ovariectomy (OVX) in Wistar rats. Nociceptive behaviors (secondary mechanical allodynia and weight-bearing distribution of the hind paws) were analyzed prior to surgery and every week, beginning at 12 weeks after surgery, up to 20 weeks...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27234864/-treatment-methods-of-atypical-gunshot-wounds-to-the-head-case-reports
#12
Paweł Mielniczek, Grzegorz Zieliński, Andrzej Koziarski
Due to a high mortality rate, headshot injuries pose serious diagnostic and clinical problems. In this work, we wanted to describe four atypical headshot injuries. The first patient with a headshot injury using a nail gun mishap; the second one after a headshot injury, as a result of attempted murder (the bullet came to a parasagittal halt in the left parietal area); the third victim, after a suicide attempt (the bullet was removed from clivus area, below the pituitary gland); in the case of the fourth patient, after shooting himself with a self-constructed weapon in the chin, the metal body was surgically removed - a bearing pellet from the corpus callosum...
May 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27216235/exploring-anti-inflammatory-potential-of-thiazolidinone-derivatives-of-benzenesulfonamide-via-synthesis-molecular-docking-and-biological-evaluation
#13
Sanjay B Bari, Sandip D Firake
BACKGROUND: The present study reports the synthesis and biological evaluation of thiazolidinone derivatives bearing benzenesulfonamide investigated for cyclooxygenase-2 (COX-2) inhibitory activity and in vivo anti-inflammatory activity. METHODS: The synthesis of 4-(4-oxo-2-substituted-1,3-thiazolidin-3-yl) benzenesulfonamide derivatives were carried out by conventional synthesis, involves the one-pot condensation reaction of sulfanilamide. The synthesized compounds were evaluated against COX-1 and human recombinant COX-2 by using colorimetric enzyme assay kit and in-vivo study was carried out by carageenan induced rat paw edema method...
May 24, 2016: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27214709/the-monoiodoacetate-model-of-osteoarthritis-pain-in-the-mouse
#14
Thomas Pitcher, João Sousa-Valente, Marzia Malcangio
A major symptom of patients with osteoarthritis (OA) is pain that is triggered by peripheral as well as central changes within the pain pathways. The current treatments for OA pain such as NSAIDS or opiates are neither sufficiently effective nor devoid of detrimental side effects. Animal models of OA are being developed to improve our understanding of OA-related pain mechanisms and define novel pharmacological targets for therapy. Currently available models of OA in rodents include surgical and chemical interventions into one knee joint...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27158400/activation-of-spinal-mrgc-gi-nr2b-nnos-signaling-pathway-by-mas-oncogene-related-gene-c-receptor-agonist-bovine-adrenal-medulla-8-22-attenuates-bone-cancer-pain-in-mice
#15
Yu'e Sun, Juan Zhang, Yishan Lei, Cui'e Lu, Bailing Hou, Zhengliang Ma, Xiaoping Gu
OBJECTIVES: In the present study, we investigate the effects of Mas oncogene-related gene (Mrg) C receptors (MrgC) on the expression and activation of spinal Gi protein, N-methyl-D-aspartate receptor subunit 2B (NR2B), and neuronal nitric oxide synthase (nNOS) in mouse model of bone cancer pain. METHODS: The number of spontaneous foot lift (NSF) and paw withdrawal mechanical threshold (PWMT) were measured after inoculation of tumor cells and intrathecal injection of MrgC agonist bovine adrenal medulla 8-22 (BAM8-22) or MrgC antagonist anti-MrgC for 14 days after operation...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27153086/an-immunosuppressant-peptide-from-the-hard-tick-amblyomma-variegatum
#16
Yufeng Tian, Wenlin Chen, Guoxiang Mo, Ran Chen, Mingqian Fang, Gabriel Yedid, Xiuwen Yan
Ixodid ticks are well known for spreading transmitted tick-borne pathogens while being attached to their hosts for almost 1-2 weeks to obtain blood meals. Thus, they must secrete many immunosuppressant factors to combat the hosts' immune system. In the present work, we investigated an immunosuppressant peptide of the hard tick Amblyomma variegatum. This peptide, named amregulin, is composed of 40 residues with an amino acid sequence of HLHMHGNGATQVFKPRLVLKCPNAAQLIQPGKLQRQLLLQ. A cDNA of the precursor peptide was obtained from the National Center for Biotechnology Information (NCBI, Bethesda, MD, USA)...
2016: Toxins
https://www.readbyqxmd.com/read/27145816/selective-inhibition-of-tropomyosin-receptor-kinase-a-trka-reduces-pain-and-joint-damage-in-two-rat-models-of-inflammatory-arthritis
#17
Sadaf Ashraf, Karyn S Bouhana, Jed Pheneger, Steven W Andrews, David A Walsh
BACKGROUND: Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA). NGF blockade has reduced arthritis pain in clinical trials. We explored the mechanisms within the joint which may contribute to the analgesic effects of NGF by selectively inhibiting TrkA in carrageenan-induced or collagen-induced joint pain behaviour...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27094782/biphalin-preferentially-recruits-peripheral-opioid-receptors-to-facilitate-analgesia-in-a-mouse-model-of-cancer-pain-a-comparison-with-morphine
#18
Anna Lesniak, Marta Bochynska-Czyz, Mariusz Sacharczuk, Sandor Benhye, Aleksandra Misicka, Magdalena Bujalska-Zadrozny, Andrzej W Lipkowski
The search for new drugs for cancer pain management has been a long-standing goal in basic and clinical research. Classical opioid drugs exert their primary antinociceptive effect upon activating opioid receptors located in the central nervous system. A substantial body of evidence points to the relevance of peripheral opioid receptors as potential targets for cancer pain treatment. Peptides showing limited blood-brain-barrier permeability promote peripheral analgesia in many pain models. In the present study we examined the peripheral and central analgesic effect of intravenously administered biphalin - a dimeric opioid peptide in a mouse skin cancer pain model, developed by an intraplantar inoculation of B16F0 melanoma cells...
June 30, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27053308/the-effect-of-comprehensive-musculoskeletal-rehabilitation-on-clinical-status-of-ankylosing-spondylitis-patients
#19
Krystyna Księżopolska-Orłowska, Anna Pacholec, Joanna Bugajska, Teresa Sadura-Sieklucka, Katarzyna Kowalik, Karolina Pawłowska-Cyprysiak, Elżbieta Łastowiecka-Moras
BACKGROUND: This study aimed to compare the effectiveness of conventional and cryotherapy-based rehabilitation with respect to its impact on selected clinical parameters in AS patients. MATERIAL AND METHODS: Fifty working males aged 22-66 years were included in this study. Twenty-five of them underwent cryotherapy-based rehabilitation (cryogenic chamber, local cryotherapy; individual, instrumental, and nonweight-bearing exercises) for 3 weeks. The others received 3 weeks of conventional rehabilitation (magnetic field therapy; electrotherapy; individual and instrumental exercises)...
January 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/26997161/studies-on-influence-of-polymer-modifiers-for-fluorescent-nanocrystals-cytotoxicity
#20
Ilona Grabowska-Jadach, Marcin Drozd, Joanna Biegala, Mariusz Pietrzak, Marta Mazurkiewicz-Pawlicka, Paweł G Parzuchowski, Zbigniew Brzózka
The presented studies aimed at investigation of the effect of CdSeS/ZnS quantum dots (QDs) stabilized with hyperbranched polyglycidol and its carboxylated derivative on adenocarcinomic human alveolar basal epithelial cells (A549). The first stage of studies concerned the modification of quantum dots with both types of the tested polymers with the use of pyridine as an intermediate agent. Subsequently, cytotoxic effect of the prepared nanoparticles was examined after various incubation time using MTT test (cell metabolic activity assay)...
August 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
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