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https://www.readbyqxmd.com/read/28742191/high-progesterone-levels-during-the-luteal-phase-related-to-the-use-of-an-aromatase-inhibitor-in-breast-cancer-patients
#1
C Alviggi, R Marci, R Vallone, A Conforti, F Di Rella, I Strina, S Picarelli, P De Rosa, M De Laurentiis, C Yding Andersen, G De Placido
OBJECTIVE: To evaluate the hormonal profile in three breast cancer patients who underwent controlled ovarian stimulation in the presence of the aromatase inhibitor letrozole. PATIENTS AND METHODS: In IVF University referral center, a case series of three breast cancer patients who underwent controlled ovarian stimulation (COS) with recombinant FSH and letrozole were investigated. Ovulation was induced with hCG (case No. 1) or with GnRH agonist (case No. 2-3). The primary outcome of our study was the detection of progesterone levels in the luteal phase...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28737050/efficacy-of-elagolix-in-the-treatment-of-endometriosis
#2
Alexandra Perricos, René Wenzl
Much research has gone into developing medications that can be used to alleviate endometriosis-associated symptoms. In addition to already established medications, a new GnRH antagonist, elagolix, is in development. The novelty of this drug compared to other GnRH antagonists, is its nonpeptide structure, allowing it to be administered orally. Areas covered: We analyzed several Phase I, II and III clinical trials that have evaluated the safety and efficacy of this new medication. Expert opinion: Since many medications have been put on the market and have gained popularity for the treatment of endometriosis-associated symptoms, the demonstration of equality or superiority of effect, tolerability, as well as patient compliance should be assessed when introducing a new drug...
July 24, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28736136/prostaglandin-e2-modulates-presynaptic-regulation-of-gnrh-neurons-via-ep4-receptors-in-accordance-with-estrogen-milieu
#3
Hitomi Fujioka, Toshiya Funabashi, Tatsuo Akema
Prostaglandin E2 (PGE2) promotes gonadotropin secretion by regulating the activity of neurons that release gonadotropin-releasing hormone (GnRH) in the hypothalamus. However, the mechanisms of action of PGE2 at these neurons have yet to be fully explored. We examined the effects of PGE2 on the generation of miniature excitatory postsynaptic currents (mEPSCs) at GnRH neurons as measured by whole-cell, patch-clamp recordings. GnRH neurons were identified in slices prepared from the preoptic areas of female GnRH-EGFP rats...
July 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28721180/adenomyosis-back-to-the-future
#4
Z Ferraz, N Nogueira-Martins, F Nogueira-Martins
Adenomyosis is a benign invasion of endometrium into the myometrium. It produces a diffusely enlarged uterus and predominantly affects women in the late reproductive age. It has recently been associated with a negative impact on female fertility. Diagnosis is challenging because nonspecific symptoms can be present. However, it is asymptomatic in the majority of women. Medical treatment with GnRH agonist seems to be promising, particularly in subfertile women. A retrospective study was performed (182 patients) by examination of histopathological results with "adenomyosis" between January/2013 and September/2016...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28715965/dual-triggering-with-gonadotropin-releasing-hormone-agonist-and-standard-dose-human-chorionic-gonadotropin-in-patients-with-a-high-immature-oocyte-rate
#5
Alberta Maria Fabris, M Cruz, V Legidos, C Iglesias, M Muñoz, J A García-Velasco
In in vitro fertilization (IVF) cycles, some patients show a high rate of immature oocytes retrieved after controlled ovarian stimulation. In vitro oocyte maturation is an experimental technique, with poorer results than conventional IVF. For this reason, improving in vivo maturation could meliorate the reproductive outcome of these patients. We performed a retrospective, not interventional, study analyzing the difference in the number and percentage of mature oocytes retrieved in patients with more than 50% immature oocytes in a previous IVF cycle triggered with human chorionic gonadotropin (hCG) compared to the number and rate of mature oocytes retrieved in subsequent cycles, triggered with both gonadotropin-releasing hormone agonist (GnRH-a) and hCG...
August 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28711383/gonadotropin-releasing-hormone-agonists-orchiectomy-and-risk-of-cardiovascular-disease-semi-ecologic-nationwide-population-based-study
#6
Frederik Birkebæk Thomsen, Fredrik Sandin, Hans Garmo, Ingela Franck Lissbrant, Göran Ahlgren, Mieke Van Hemelrijck, Jan Adolfsson, David Robinson, Pär Stattin
BACKGROUND: In observational studies, men with prostate cancer treated with gonadotropin-releasing hormone (GnRH) agonists had a higher risk of cardiovascular disease (CVD) compared to men who had undergone orchiectomy. However, selection bias may have influenced the difference in risk. OBJECTIVE: To investigate the association of type of androgen deprivation therapy (ADT) with risk of CVD while minimising selection bias. DESIGN, SETTING, AND PARTICIPANTS: Semi-ecologic study of 6556 men who received GnRH agonists and 3330 men who underwent orchiectomy as primary treatment during 1992-1999 in the Prostate Cancer Database Sweden 3...
July 12, 2017: European Urology
https://www.readbyqxmd.com/read/28710674/what-is-the-best-predictor-of-severe-ovarian-hyperstimulation-syndrome-in-ivf-a-cohort-study
#7
Theoni B Tarlatzi, Christos A Venetis, Fabienne Devreker, Yvon Englert, Anne Delbaere
PURPOSE: The purpose of the present study is to study what is the best predictor of severe ovarian hyperstimulation syndrome (OHSS) in IVF. METHODS: This is a retrospective analysis of all consecutive IVF/intracytoplasmic injection cycles performed during a 5-year period (2009-2014) in a single university fertility centre. All fresh IVF cycles where ovarian stimulation was performed with gonadotrophins and GnRH agonists or antagonists and triggering of final oocyte maturation was induced with the administration of urinary or recombinant hCG were analyzed (2982 patients undergoing 5493 cycles)...
July 14, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28706366/gnrh-antagonist-cetrorelix-administration-before-hcg-for-protection-of-ovarian-hyperstimulation-syndrome
#8
Sherif A Hebisha, Banan A Aboelazm, H N Sallam
OBJECTIVE: Studying the effect of GnRH antagonist administration on the day of hCG to cases of IVF/ICSI with estradiol level above 5000 ng/dl for protection of ovarian hyperstimulation syndrome. DESIGN: Prospective study. MATERIALS AND METHODS: Sixty patients undergoing controlled hyperstimulation COH, for IVF/ICSI using long agonist and E2 level on the day of hCG, are above 5000 ng/dl, 52 patients received single dose of cetrorelix 0.25 mg on the day of hCG, and 8 patients received two doses of 0...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28697910/duphaston-and-human-menopausal-gonadotropin-protocol-in-normally-ovulatory-women-undergoing-controlled-ovarian-hyperstimulation-during-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-treatments-in-combination-with-embryo-cryopreservation
#9
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
OBJECTIVE: To evaluate endocrine characteristics and clinical outcomes in normal ovulatory patients undergoing controlled ovarian hyperstimulation (COH) with the use of a Duphaston and hMG protocol during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments in combination with frozen-thawed embryo transfer (FET) compared with the characteristics and outcomes of patients undergoing an Utrogestan and hMG protocol. DESIGN: Prospective controlled study...
July 8, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28683602/postoperative-levonorgestrel-releasing-intrauterine-system-insertion-after-gonadotropin-releasing-hormone-agonist-treatment-for-preventing-endometriotic-cyst-recurrence-a-prospective-observational-study
#10
Min Kyoung Kim, Seung Joo Chon, Jae Hoon Lee, Bo Hyon Yun, SiHyun Cho, Young Sik Choi, Byung Seok Lee, Seok Kyo Seo
OBJECTIVE: The aim of this study was to evaluate the effectiveness of postoperative levonorgestrel-releasing intrauterine system (LNG-IUS) insertion after gonadotropin-releasing hormone agonist (GnRH-a) treatment for preventing endometriotic cyst recurrence. STUDY DESIGN: The LNG-IUS was applied to 28 women who had undergone surgery for endometriosis followed by 6 cycles of GnRH-a treatment. Clinical characteristics, endometriosis recurrence, and adverse effects were analyzed...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28680360/oxidative-stress-markers-in-gnrh-agonist-and-antagonist-protocols-in-ivf
#11
Lidija Tulić, Snežana Vidaković, Ivan Tulić, Marijana Ćurčić, Jelena Stojnić, Katarina Jeremić
BACKGROUND: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. METHODS: This prospective study included 82 patients who underwent IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation...
April 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28674785/follicular-sensitivity-index-fsi-a-novel-tool-to-predict-clinical-pregnancy-rate-in-ivf-icsi-cycles
#12
AbdelGany M A Hassan, Mohamed M M Kotb, Ahmed M A AwadAllah, Nesreen A A Shehata, Amr Wahba
PURPOSE: This study aims to introduce a new tool (the Follicular Sensitivity Index; FSI) for objective assessment of follicular responsiveness to exogenous gonadotropins and to evaluate its ability to predict the clinical pregnancy rate in women with unexplained infertility or tubal factor undergoing IVF/ICSI. METHODS: FSI was calculated as preovulatory follicle count (PFC) × 100,000/[antral follicle count (AFC) × total received FSH doses]. One thousand women were included and were divided according to the FSI tertile values into three groups...
July 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28670424/a-comparison-of-outcomes-from-in-vitro-fertilization-cycles-stimulated-with-follicle-stimulating-hormone-plus-either-recombinant-luteinizing-hormone-or-human-menopausal-gonadotropins-in-subjects-treated-with-long-gonadotropin-releasing-hormone-agonist-protocols
#13
Nathalie Bleau, Mohammed Agdi, WeonYoung Son, SeangLin Tan, Michael H Dahan
BACKGROUND: This study compared rates of pregnancy and in vitro fertilization (IVF) parameters in subjects stimulated with follicle stimulating hormone (FSH) plus either recombinant human luteinizing hormone (r-LH) or human menopausal gonadotropin (hMG) in a long gonadotropin releasing hormone (GnRH) agonist IVF protocol. MATERIALS AND METHODS: This cohort study enrolled patients who underwent IVF stimu- lation with a long GnRH agonist protocol and received FSH plus r-LH or hMG...
July 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28665507/participation-of-hypothalamic-cb1-receptors-in-reproductive-axis-disruption-during-immune-challenge
#14
Pablo Nicolás Surkin, María Emilia Di Rosso, Fernando Correa, Juan Carlos Elverdin, Ana María Genaro, Andrea De Laurentiis, Javier Fernández-Solari
It is known that immune challenge inhibits reproductive function and that endocannabinoids (eCB) modulate sexual hormones. However, no studies have been performed to assess whether the endocannabinoid system mediates the inhibition of hormones that control reproduction due to immune system activation during systemic infections. For that reason, we evaluated the participation of the hypothalamic cannabinoid receptor CB1 on hypothalamic-pituitary-gonadal (HPG) axis activity in rats submitted to immune challenge...
June 30, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28663739/impact-of-mid-luteal-phase-gnrh-agonist-administration-on-reproductive-outcomes-in-gnrh-agonist-triggered-cycles-a-randomized-controlled-trial
#15
Abdelhamid Benmachiche, Sebti Benbouhedja, Abdelali Zoghmar, Amel Boularak, Peter Humaidan
OBJECTIVE: To explore whether the addition of a mid-luteal bolus of GnRH agonist (GnRHa) improves the implantation rate (IR) in in vitro fertilization (IVF) cycles. DESIGN: A randomized controlled trial. SETTING: Private IVF center. PATIENTS: 328 IVF/intracytoplasmic sperm injection patients were triggered with GnRHa and received 1,500 IU HCG on the day of oocyte pick-up (OPU) in addition to a standard luteal phase support (LPS)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28649232/ion-channels-of-pituitary-gonadotrophs-and-their-roles-in-signaling-and-secretion
#16
REVIEW
Stanko S Stojilkovic, Ivana Bjelobaba, Hana Zemkova
Gonadotrophs are basophilic cells of the anterior pituitary gland specialized to secrete gonadotropins in response to elevation in intracellular calcium concentration. These cells fire action potentials (APs) spontaneously, coupled with voltage-gated calcium influx of insufficient amplitude to trigger gonadotropin release. The spontaneous excitability of gonadotrophs reflects the expression of voltage-gated sodium, calcium, potassium, non-selective cation-conducting, and chloride channels at their plasma membrane (PM)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28647447/dienogest-therapy-as-a-treatment-for-catamenial-pneumothorax-case-report-and-review-of-hormonal-options
#17
Shifana Lalani, Amanda Black, Meryl C Hodge, Togas Tulandi, Innie Chen
BACKGROUND: Catamenial pneumothorax is a rare but serious condition for women of reproductive age. We describe a trial of dienogest as hormonal therapy for catamenial pneumothorax and review the literature on hormonal suppressive therapy for this condition. CASE: A 39-year-old female, gravida 0 para 0, presented with recurrent pneumothoraces coinciding with her menses. After surgical therapy, she was started on leuprolide acetate injections for 6 months to reduce recurrence...
June 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28638367/gnrh-agonist-trigger-and-lh-activity-luteal-phase-support-versus-hcg-trigger-and-conventional-luteal-phase-support-in-fresh-embryo-transfer-ivf-icsi-cycles-a-systematic-prisma-review-and-meta-analysis
#18
REVIEW
Thor Haahr, Matheus Roque, Sandro C Esteves, Peter Humaidan
INTRODUCTION: The use of GnRH agonist (GnRHa) for final oocyte maturation trigger in oocyte donation and elective frozen embryo transfer cycles is well established due to lower ovarian hyperstimulation syndrome (OHSS) rates as compared to hCG trigger. A recent Cochrane meta-analysis concluded that GnRHa trigger was associated with reduced live birth rates (LBRs) in fresh autologous IVF cycles compared to hCG trigger. However, the evidence is not unequivocal, and recent trials have found encouraging reproductive outcomes among couples undergoing GnRHa trigger and individualized luteal LH activity support...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28625761/impact-of-vitamin-d-levels-on-ovarian-reserve-and-ovarian-response-to-ovarian-stimulation-in-oocyte-donors
#19
Alberta Maria Fabris, Maria Cruz, Carlos Iglesias, Alberto Pacheco, Azadeh Patel, Jayesh Patel, Human Fatemi, Juan Antonio García-Velasco
Recently, growing interest in vitamin D has emerged from findings that demonstrate a low vitamin D status in populations. Similarly, much interest has been shown in the role that anti-Müllerian hormone (AMH) plays in reproductive physiology. Considerable confusion as to whether vitamin D status is related to ovarian function can be found in the literature. Our retrospective study was performed from June 2014 to April 2015. Oocyte donors were recruited and stimulated under the antagonist protocol with gonadotrophin-releasing hormone (GnRH) agonist to trigger ovulation...
May 19, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28620352/efficacy-of-follicle-stimulating-hormone-fsh-alone-fsh%C3%A2-%C3%A2-luteinizing-hormone-human-menopausal-gonadotropin-or-fsh%C3%A2-%C3%A2-human-chorionic-gonadotropin-on-assisted-reproductive-technology-outcomes-in-the-personalized-medicine-era-a-meta-analysis
#20
Daniele Santi, Livio Casarini, Carlo Alviggi, Manuela Simoni
SETTING: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) act on the same receptor, activating different signal transduction pathways. The role of LH or hCG addition to follicle-stimulating hormone (FSH) as well as menopausal gonadotropins (human menopausal gonadotropin; hMG) in controlled ovarian stimulation (COS) is debated. OBJECTIVE: To compare FSH + LH, or FSH + hCG or hMG vs. FSH alone on COS outcomes. DESIGN: A meta-analysis according to PRISMA statement and Cochrane Collaboration was performed, including prospective, controlled clinical trials published until July 2016, enrolling women treated with FSH alone or combined with other gonadotropins...
2017: Frontiers in Endocrinology
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