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GNRH Agonist

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https://www.readbyqxmd.com/read/29782310/putative-gonadotropin-releasing-hormone-agonist-therapy-and-dementia-an-application-of-medicare-hospitalization-claims-data
#1
Mark A Smith, Richard L Bowen, Richard Q Nguyen, George Perry, Craig S Atwood, Alfred A Rimm
BACKGROUND: Estrogen and hormone replacement therapies to reduce Alzheimer's disease (AD) have yielded conflicting results. However, this study proposes that the well-characterized increase in serum gonadotropins following menopause or andropause are accountable for the increased risk of developing AD among the elderly population. OBJECTIVE: To determine the role of gonadotropins in the development of AD and investigate gonadotropin-releasing hormone (GnRH) agonist therapy as a potential preventative and/or disease-modifying approach to AD management...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29778367/role-of-gonadotropin-releasing-hormone-agonists-human-chorionic-gonadotropin-hcg-progesterone-and-estrogen-in-luteal-phase-support-after-hcg-triggering-and-when-in-pregnancy-hormonal-support-can-be-stopped
#2
REVIEW
Dominique de Ziegler, Paul Pirtea, Claus Yding Andersen, Jean Marc Ayoubi
Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG-used for triggering ovulation-vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29765929/gonadotropin-releasing-hormone-agonist-plus-aromatase-inhibitor-in-the-treatment-of-uterine-leiomyoma-in-near-menopause-patient-a-case-series-study
#3
Sanam Moradan
Objectives: There are many drugs for of symptomatic fibroids. Gonadotropin-releasing hormone (GnRH) agonists are the well known drugs. Also, aromatase inhibitors are effective. All published studies surveyed the effect of one of these two drugs. In this study as the first study decided to evaluate the effectiveness of the combination of GnRH agonists + aromatise inhibitor on the uterine fibroids. Methods: A cross-sectional prospective case series study was performed on 10 known cases of uterine fibroids late perimenopause, at least 3 myomas >5 cm, abnormal uterine bleeding and anemia due to fibroids, candidate for hysterectomy, no tendency to surgery...
April 2018: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29754425/effects-of-oestradiol-for-luteal-phase-support-in-fresh-embryo-transfer-cycles-a-retrospective-cohort-study
#4
Wei Zhao, Yifeng Liu, Peng Xu, Yiqing Wu, Kai Chen, Xiaoyan Guo, Fan Zhang, Yun Huang, Linlin Zhu, Runjv Zhang, Dan Zhang
OBJECTIVE: Any benefit of oestradiol supplementation with progesterone for luteal support after fresh embryo transfer in in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) cycles remains controversial. In this study, we further addressed this question in cycles using gonadotropin-releasing hormone (GnRH) agonist for ovarian stimulation. DESIGN: A retrospective cohort study in a tertiary teaching and research hospital. PATIENT(S): A total of 1602 patients were given oestradiol valerate (E) in addition to progesterone(P) as luteal support...
May 12, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29747158/delayed-return-to-estrus-following-treatment-with-the-gonadotrophin-releasing-hormone-agonist-lucrin-%C3%A2-depot-in-the-tammar-wallaby
#5
Ryan R Witt, Lyn A Hinds, John C Rodger
Gonadotrophin-releasing hormone agonists that induce a reversible contraceptive state in several marsupials have the potential to be used to synchronize estrus. We used a model macropod, the tammar wallaby (Notamacropus eugenii), to investigate whether Lucrin Depot (AbbVie), a GnRH agonist microsphere preparation, could (1) inhibit follicular development and estrus in a cycle reactivated by removal of pouch young (RPY) and (2) facilitate a synchronous return to estrus. Our results show that females reactivated with bromocriptine and RPY in early seasonal quiescence (July 2015) were inhibited by Lucrin Depot (0...
April 30, 2018: Theriogenology
https://www.readbyqxmd.com/read/29743877/follicle-size-on-day-of-trigger-most-likely-to-yield-a-mature-oocyte
#6
Ali Abbara, Lan N Vuong, Vu N A Ho, Sophie A Clarke, Lisa Jeffers, Alexander N Comninos, Rehan Salim, Tuong M Ho, Tom W Kelsey, Geoffrey H Trew, Peter Humaidan, Waljit S Dhillo
Objective: To identify follicle sizes on the day of trigger most likely to yield a mature oocyte following hCG, GnRH agonist (GnRHa), or kisspeptin during IVF treatment. Design: Retrospective analysis to determine the size of follicles on day of trigger contributing most to the number of mature oocytes retrieved using generalized linear regression and random forest models applied to data from IVF cycles (2014-2017) in which either hCG, GnRHa, or kisspeptin trigger was used...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29738181/-repeated-superovulation-induction-after-failure-in-previous-ivf-et-cycles-with-the-ultra-long-protocol-analysis-of-outcomes-of-clinical-pregnancy
#7
Bin Wang, Na Kong, Jing-Yu Liu, Ning-Yuan Zhang, Ying-Chun Zhu, Jian-Jun Zhou
Objective: To analyze the clinical outcomes of repeated superovulation induction in patients with adenomyosis or moderate to severe pelvic endometriosis after failure in previous IVF-ET cycles with the ultra-long protocol. METHODS: We retrospectively analyzed the clinical data about 37 patients with adenomyosis or moderate to severe pelvic endometriosis in our center from 2009 to 2013, who underwent repeated IVF-ET after failure in the previous cycles with the ultra-long protocol, namely by injection of 2-6 ampoules of 3...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29728130/low-dose-clomiphene-citrate-as-a-mild-stimulation-protocol-in-women-with-unsuspected-poor-in-vitro-fertilization-result-can-generate-more-oocytes-with-optimal-cumulative-pregnancy-rate
#8
Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui, Jiayin Liu
BACKGROUND: The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dose gonadotropins could be useful alternative regimen to address such problems. This study evaluated the efficacy of low dose clomiphene citrate based protocol plus low dose gonadotropins on predicted normal responder patients who had unsuspected poor in vitro fertilization (IVF) result, following an initial stimulation with long gonadotropin-releasing hormone (GnRH) agonist protocol...
May 4, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29725582/circulating-thyrotropin-is-upregulated-by-estradiol
#9
Salvatore Benvenga, Flavia Di Bari, Roberta Granese, Irene Borrielli, Grazia Giorgianni, Loredana Grasso, Maria Le Donne, Roberto Vita, Alessandro Antonelli
After encountering two women with serum thyrotropin (TSH) levels greater in periovulatory phase than in other days of the menstrual cycle, we hypothesized that TSH levels could be sensitive to changes in circulating estrogens in women. The objective of this study was to evaluate whether serum TSH increases after an induced acute increase of serum estradiol, and compare serum TSH increase with that of prolactin (PRL) which is a classic estradiol-upregulated pituitary hormone. In this retrospective study, we resorted to stored frozen sera from 55 women who had undergone the GnRH agonist (buserelin)-acute stimulation test of ovarian steroidogenesis...
March 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29718788/vilaprisan-for-treating-uterine-fibroids
#10
Gian Benedetto Melis, Manuela Neri, Bruno Piras, Anna Maria Paoletti, Silvia Ajossa, Monica Pilloni, Maria Francesca Marotto, Valentina Corda, Alessandra Saba, Elena Giancane, Valerio Mais
Introduction The medical strategy to antagonize myoma size and related-symptoms is to reduce estrogen and progesterone activity on myomas. This can be obtained with the GnRH agonist (GnRHa) or with compounds that antagonize progesterone stimulatory activity on myomas. Selective progesterone receptor modulators (SPRMs) bind progesterone receptor (PR), leading to both agonist and antagonist effects. The result of SPRMs's action is tissue-specific and it depends on the particular affinity and strength of each SPRM...
May 2, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29709317/estrus-suppression-in-dogs
#11
REVIEW
Michelle Anne Kutzler
Since 1952, scientists have studied estrus suppression in dogs. Estrus suppression in dogs must be safe and reliable. Medications used for estrus suppression in bitches include gonadotropin-releasing hormone (GnRH) agonists, GnRH antagonists, progestogens, and androgens. Despite widespread availability of these medications throughout the rest of the world, there are no drugs currently labeled for canine estrus induction in the United States.
April 27, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29696351/the-effects-of-superovulation-with-gonadotropins-on-autoantibody-levels-in-patients-undergoing-assisted-reproductive-cycles
#12
Mahnaz Ashrafi, Elham Amirchaghmaghi, Arezoo Arabipoor, Samira Vesali, Reza Salman-Yazdi
PURPOSE: To evaluate the effect of controlled ovarian stimulation (COH) with gonadotropins on the serum levels of autoantibodies in the women who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles and to compare basal levels of these autoantibodies between groups according to history of COH. METHODS: This prospective cohort study was performed from October 2014 to March 2016 in the Royan Institute. The volunteered infertile women with regard to the inclusion criteria, who underwent IVF/ICSI cycles, were recruited...
April 25, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29696192/the-dual-trigger-study-rationale-and-study-design-of-a-prospective-double-blind-randomized-clinical-trial-comparing-pregnancy-rates-after-co-administration-of-low-dose-hcg-at-the-time-of-gnrh-agonist-trigger-or-35-h-later-for-the-prevention-of-ohss
#13
Daniel Griffin, Claudio Benadiva, Tara Budinetz, Carolina Sueldo, Andrea DiLuigi, John Nulsen, Lawrence Engmann
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of controlled ovarian stimulation. The use of gonadotropin releasing hormone (GnRH) agonist for the trigger of oocyte maturation is effective in the prevention of OHSS although it may result in a lower pregnancy rate. The use of adjuvant low dose human chorionic gonadotropin (hCG) at the time of trigger or at the time of oocyte retrieval may improve pregnancy rates. The goal of this dual trigger study is to evaluate the safety and efficacy of the use of low dose hCG administered at the time of GnRH agonist trigger or 35 h later as well as the potential impact on pregnancy rates...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29695208/comparison-of-modified-agonist-mild-stimulation-and-antagonist-protocols-for-in-vitro-fertilization-in-patients-with-diminished-ovarian-reserve
#14
Rong Yu, Hao Jin, Xuefeng Huang, Jinju Lin, Peiyu Wang
Objective To compare the efficacy of three protocols for ovarian stimulation in patients with diminished ovarian reserve during in vitro fertilization (IVF) treatment. Methods This prospective randomized study enrolled patients with diminished ovarian reserve who underwent cycles of IVF or intracytoplasmic sperm injection. The patients were randomly divided into three groups: a modified gonadotrophin releasing hormone (GnRH) agonist protocol (group A); (ii) a mild stimulation protocol (group B); or (iii) an antagonist protocol (group C)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29692679/clinical-outcomes-of-assisted-reproductive-technology-treatment-by-using-a-self-injection-of-recombinant-human-chorionic-gonadotropin-as-the-final-maturation-trigger
#15
Koji Nakagawa, Midori Oba, Kaori Ehara, Nozomi Ishigaki, Nao Ino, Akiko Itakura, Ryo Tsutsumi, Katsuki Nakao, Yuko Ojiro, Rikikazu Sugiyama
Purpose: To evaluate the efficacy and safety of self-injections of the prefilled recombinant human chorionic gonadotropin (r-hCG) in a syringe in assisted reproductive technology (ART) treatment for the maturation trigger (MT), as compared to self-injections of conventional hCG and intranasal administration of gonadotropin-releasing hormone agonist (GnRH-a). Methods: Between January and April, 2017, 396 patients who underwent oocyte retrieval were recruited. Of these, 396 patients were classified into three groups, according to the types of MT: (1) the urinary human chorionic gonadotropin (u-hCG) group that consisted of patients who had a self-injection of u-hCG (n = 127); (2) the GnRH-a group that received nasal administration of GnRH-a (n = 159); and (3) the r-hCG group that had a self-injection of r-hCG (n = 110)...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29681889/role-of-kisspeptin-and-neurokinin-b-in-puberty-in-female-non-human-primates
#16
REVIEW
Ei Terasawa, James P Garcia, Stephanie B Seminara, Kim L Keen
In human patients, loss-of-function mutations in the genes encoding kisspeptin ( KISS1 ) and neurokinin B ( NKB) and their receptors ( KISS1R and NK3R , respectively) result in an abnormal timing of puberty or the absence of puberty. To understand the neuroendocrine mechanism of puberty, we investigated the contribution of kisspeptin and NKB signaling to the pubertal increase in GnRH release using rhesus monkeys as a model. Direct measurements of GnRH and kisspeptin in the median eminence of the hypothalamus with infusion of agonists and antagonists for kisspeptin and NKB reveal that kisspeptin and NKB signaling stimulate GnRH release independently or collaboratively by forming kisspeptin and NKB neuronal networks depending on the developmental age...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29680315/luteal-phase-support-after-gonadotropin-releasing-hormone-agonist-triggering-does-it-still-matter
#17
REVIEW
Claudio Benadiva, Lawrence Engmann
Despite the increasing utilization of freeze-only IVF protocols, there is still a need for adequate management of the luteal phase after GnRH agonist trigger for patients who desire a fresh embryo transfer. Two approaches, intensive luteal support with E2 and P, and the use of adjuvant low-dose hCG either at the time of GnRH agonist trigger (dual trigger) or at the time of oocyte retrieval, have been shown to be effective in maintaining adequate pregnancy outcomes. The addition of low-dose hCG should be used with caution, because it may increase the risk of ovarian hyperstimulation syndrome...
April 18, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29675483/fresh-versus-frozen-embryo-transfer-after-gonadotropin-releasing-hormone-agonist-trigger-in-gonadotropin-releasing-hormone-antagonist-cycles-among-high-responder-women-a-randomized-multi-center-study
#18
Abbas Aflatoonian, Mahnaz Mansoori-Torshizi, Maryam Farid Mojtahedi, Behrouz Aflatoonian, Mohammaad Ali Khalili, Mohammad Hossein Amir-Arjmand, Mehrdad Soleimani, Nastaran Aflatoonian, Homa Oskouian, Nasim Tabibnejad, Peter Humaidan
Background: The use of embryo cryopreservation excludes the possible detrimental effects of ovarian stimulation on the endometrium, and higher reproductive outcomes following this policy have been reported. Moreover, gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone (GnRH) antagonist cycles as a substitute for standard human chorionic gonadotropin trigger, minimizes the risk of ovarian hyperstimulation syndrome (OHSS) in fresh as well as frozen embryo transfer cycles (FET)...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29674281/effects-of-tocotrienol-from-bixa-orellana-annatto-on-bone-histomorphometry-in-a-male-osteoporosis-model-induced-by-buserelin
#19
Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin
INTRODUCTION: Osteoporosis is a debilitating skeletal side effect of androgen deprivation therapy based on gonadotropin-releasing hormone (GnRH) agonist in men. Tocotrienol from Bixa orellana (annatto) has been demonstrated to offer protection against osteoporosis by exerting anabolic effects on bone. Thus, it may prevent osteoporosis among GnRH agonist users. OBJECTIVE: This study aimed to determine the effectiveness of annatto-tocotrienol on the bone turnover markers and bone histomorphometry in a model of male osteoporosis induced by buserelin (a GnRH agonist)...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29669803/growth-hormone-in-combination-with-leuprorelin-in-pubertal-children-with-idiopathic-short-stature
#20
Imane Benabbad, Myriam Rosilio, Maithe Tauber, Emmanuel Paris, Anne Fjellestad-Paulsen, Lovisa Berggren, Hiren Patel, Jean-Claude Carel
OBJECTIVE: There is a scarcity of data from randomised controlled trials on the association of growth hormone (GH) with gonadotrophin-releasing hormone (GnRH) agonists in idiopathic short stature (ISS), although this off-label use is common. We aimed to test whether delaying pubertal progression could increase near-adult height (NAH) in GH-treated patients with ISS. METHODS: Patients with ISS at puberty onset were randomised to GH with leuprorelin (combination, n=46) or GH alone (n=45)...
April 18, 2018: Endocrine Connections
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