Wilhelmina C M Duivenvoorden, David Margel, Vishal Subramony Gayathri, Emmanuelle Duceppe, Sadiya Yousef, Magda Naeim, Mohammad Khajehei, Sarah Hopmans, Snezana Popovic, Yaara Ber, Diane Heels-Ansdell, Philip J Devereaux, Jehonathan H Pinthus
Low testosterone (T), common in aging men, associates with cardiovascular disease. We investigated whether follicle-stimulating hormone (FSH), which is affected by T, modulates the cardiovascular effects associated with low T or castration. FSHβ-/- :low-density lipoprotein receptor (LDLR)-/- mice, untreated or castrated (orchiectomy, gonadotropin-releasing hormone agonist or antagonist), demonstrated significantly less atherogenesis compared with similarly treated LDLR-/- mice, but not following FSH delivery...
March 2024: JACC. Basic to Translational Science