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JOURNAL ARTICLE
Jonathan Z Pan, Zhanqiang Wang, Wei Sun, Peipei Pan, Wei Li, Yongtao Sun, Shoulin Chen, Amity Lin, Wulin Tan, Liangliang He, Jacob Greene, Virginia Yao, Lijun An, Rich Liang, Qifeng Li, Jessica Yu, Lingyi Zhang, Nikolaos Kyritsis, Xuan Duong Fernandez, Sara Moncivais, Esmeralda Mendoza, Pamela Fung, Gongming Wang, Xinhuan Niu, Qihang Du, Zhaoyang Xiao, Yuwen Chang, Peiyuan Lv, J Russell Huie, Abel Torres-Espin, Adam R Ferguson, Debra D Hemmerle, Jason F Talbott, Philip R Weinstein, Lisa U Pascual, Vineeta Singh, Anthony M DiGiorgio, Rajiv Saigal, William D Whetstone, Geoffrey T Manley, Sanjay S Dhall, Jacqueline C Bresnahan, Mervyn Maze, Xiangning Jiang, Neel S Singhal, Michael S Beattie, Hua Su, Zhonghui Guan
BACKGROUND: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions...
April 2024: Clinical and Translational Medicine
#22
JOURNAL ARTICLE
W Mamai, O Bueno-Masso, T Wallner, S A Nikièma, S Meletiou, L Deng, F Balestrino, H Yamada, J Bouyer
This study provides a comparative analysis of two state-of-the-art automatic mosquito pupae sex sorters currently available: the ORINNO and the WOLBAKI Biotech pupae sex separation systems, which both exploit the sexual size dimorphism of pupae. In Aedes aegypti, the WOLBAKI sex sorter and the ORINNO with a sieve mesh size of 1.050 mm achieved sex separation with female contamination rates below 1%, low pupae mortality rates and high male flight capacity. However, in Ae. albopictus, there was more variability, with female contamination rates above the 1% threshold and pupae mortality reaching 27% when using the ORINNO sorter...
April 22, 2024: Scientific Reports
#23
REVIEW
S Peters, S Loi, F André, S Chandarlapaty, E Felip, S P Finn, P A Jänne, K M Kerr, E Munzone, A Passaro, M Pérol, E F Smit, C Swanton, G Viale, R A Stahel
Following the approval of the first antibody-drug conjugates (ADCs) in the early 2000s, development has increased dramatically, with 14 ADCs now approved and >100 in clinical development. In lung cancer, trastuzumab deruxtecan (T-DXd) is approved in human epidermal growth factor receptor 2 (HER2)-mutated, unresectable or metastatic non-small cell lung cancer, with ADCs targeting HER3 (patritumab deruxtecan), trophoblast cell-surface antigen 2 (datopotamab deruxtecan and sacituzumab govitecan [SG]) and mesenchymal-epithelial transition factor (telisotuzumab vedotin) in late-stage clinical development...
April 20, 2024: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#24
JOURNAL ARTICLE
J Verdaguer-Faja, L Borrego, P Mercader-García, R González Pérez, S Córdoba-Guijarro, A M Giménez-Arnau, I Ruiz-González, J Miquel-Miquel, J Francisco Silvestre, F J Ortiz de Frutos, F Tous-Romero, T Sanz Sánchez, M Rodríguez-Serna, J Sánchez-Pérez, E Serra Baldrich, V Zaragoza-Ninet, M A Pastor-Nieto, M E Gatica-Ortega, A Sánchez Gilo, Gemma Melé-Ninot, P Sánchez-Pedreño Guillén, M Munera-Campos, M Á Descalzo, I García-Doval, J M Carrascosa
BACKGROUND: Psoriasis is a chronic inflammatory dermatosis whose clinical and topographic distribution requires differential diagnosis, or the possible association with allergic contact dermatitis (ACD), requiring patch testing (PT) as part of the diagnostic procedure. OBJECTIVES: To describe the epidemiological, clinical, and allergic profile of patients with a primary or secondary diagnosis of psoriasis undergoing PT and compare them with patients with a diagnosis of ACD at the end of the diagnostic process...
April 20, 2024: Actas Dermo-sifiliográficas
#25
JOURNAL ARTICLE
S Okur, L E Yanmaz, H Çınar, A Gölgeli, Ö T Orhun, F Turgut, M G Şenocak, T Arslan
The aim of this study was to evaluate the intraocular pressure (IOP) measurements obtained from first, second, and third probe-cornea touch (PCT) and compare them with the average of six PCTs using two rebound tonometers in horses. This study enrolled a total of thirty-eight stallions, comprising of 24 Arabian horses and 14 cross-breeds (with an average age of 8 ± 3 years). The IOP measurements of first, second, and third, as well as the average of six PCTs were obtained using either Tonovet (TV) or Tonovet Plus (TV+) rebound tonometers...
April 20, 2024: Journal of Equine Veterinary Science
#26
JOURNAL ARTICLE
S L Coburn, K M Crossley, J L Kemp, F Gassert, J Luitjens, S J Warden, A G Culvenor, M J Scholes, M G King, P Lawrenson, T Link, J J Heerey
OBJECTIVE: To explore associations between hip muscle strength and cartilage defects (presence and severity) on magnetic resonance imaging (MRI) in young adults with hip/groin pain participating in sub-elite football. DESIGN: Sub-elite football players with hip/groin pain (> 6 months) completed assessments of isometric hip strength and functional task performance. Hip cartilage defects were assessed using the Scoring Hip Osteoarthritis with MRI (SHOMRI) tool...
April 20, 2024: Osteoarthritis and Cartilage
#27
JOURNAL ARTICLE
Jacques Donnez, Christian Becker, Hugh Taylor, Francisco Carmona Herrera, Olivier Donnez, Andrew Horne, Maciej Paszkowski, Felice Petraglia, Stefan P Renner, Amisha Patel, Mitra Boolell, Elke Bestel, Marie-Madeleine Dolmans
STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone acetate [NETA]) demonstrate better efficacy than placebo in the management of endometriosis-related dysmenorrhea and non-menstrual pelvic pain? SUMMARY ANSWER: Combining 200 mg linzagolix with ABT was found to significantly reduce dysmenorrhea and non-menstrual pelvic pain at 3 months of therapy, while a daily dose of 75 mg linzagolix yielded a significant decrease only in dysmenorrhea at 3 months...
April 22, 2024: Human Reproduction
#28
JOURNAL ARTICLE
Tight Junction Proteins as Therapeutic Targets to Treat Liver Fibrosis and Hepatocellular Carcinoma.
Antonio Saviano, Natascha Roehlen, Thomas F Baumert
In the last decade tight junction proteins exposed at the surface of liver or cancer cells have been uncovered as mediators of liver disease biology: Claudin-1 and Occludin are host factors for hepatitis C virus entry and Claudin-1 has been identified as a driver for liver fibrosis and hepatocellular carcinoma (HCC). Moreover, Claudins have emerged as therapeutic targets for liver disease and HCC. CLDN1 expression is upregulated in liver fibrosis and HCC. Monoclonal antibodies (mAbs) targeting Claudin-1 have completed preclinical proof-of-concept studies for treatment of liver fibrosis and HCC and are currently in clinical development for advanced liver fibrosis...
April 22, 2024: Seminars in Liver Disease
#29
JOURNAL ARTICLE
Mohamed T El Halawani, Yelhla S Aboushady, Sally M Abdel Kader, Stefano Benedicenti, Luca Solimei, Antonio Signore
PURPOSE: To evaluate the marginal integrity of three inlay-retained fixed dental prosthesis (IRFDP) designs fabricated using monolithic zirconia. MATERIALS AND METHODS: In total, 30 IRFDPs were fabricated using 4-YTZP monolithic zirconia and randomly divided into three groups according to the cavity design. Groups ID2 and ID1.5 received an inlay cavity preparation, which includes a proximal box and an occlusal extension with a depth of 2 mm or 1.5 mm, respectively...
April 22, 2024: International Journal of Prosthodontics
#30
JOURNAL ARTICLE
Anna Laura Knoblauch, B-I Blaß, C Steiert, N Neidert, A Puzik, E Neumann-Haefelin, A Ganner, F Kotsis, T Schäfer, H P H Neumann, S Elsheikh, J Beck, J-H Klingler
PURPOSE: Von Hippel-Lindau (VHL) disease is an autosomal-dominantly inherited tumor predisposition syndrome. One of the most common tumors are central nervous system (CNS) hemangioblastomas. Recommendations on the initiation and continuation of the screening and surveillance program for CNS tumors in pediatric VHL patients are based on small case series and thus low evidence level. To derive more robust screening recommendations, we report on the largest monocentric pediatric cohort of VHL patients...
April 22, 2024: Journal of Neuro-oncology
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JOURNAL ARTICLE
Wei Guo, Nan Wang, Kai-Yue Zhang, Pei-Pei Song, Zhan-Qiang Ma
Metal nanoparticles could be accumulated in soils, which threatens the ecological stability of crops. Investigating the effects of cuprous oxide nanoparticles (Cu2 O-NPs) on photosystem Ⅱ (PSⅡ) of wheat seedling leaves holds considerable importance in comprehending the implications of Cu2 O-NPs on crop photosynthesis. Following the hydroponic method, we investigated the effects of 0, 10, 50, 100, and 200 mg·L-1 Cu2 O-NPs on chlorophyll fluorescence induction kinetics and photosynthetic-related genes in wheat seedlings of "Zhoumai 18"...
March 18, 2024: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
#32
JOURNAL ARTICLE
Data on electroconvulsive seizure in mice, effects of anesthesia on immediate early gene expression.
A B Ozols, K T Meyers, C C Damphousse, J M Campbell, R Khoshaba, S G Wallace, C Hu, D F Marrone, A L Gallitano
Although electroconvulsive therapy (ECT) is one of the most effective treatments for severe mood and psychotic disorders, the mechanisms underlying its therapeutic effects remain unknown. Electroconvulsive stimulation (ECS), the animal model for ECT, can be used to investigate the potential therapeutic mechanisms of ECT in rodents. ECS produces numerous effects in the brain, such as increasing levels of growth factors, inducing dendritic sprouting, and stimulating neurogenesis. It also induces high-level expression of immediate early genes (IEGs) that have been implicated in the pathogenesis of schizophrenia, such as early growth response 3 ( Egr3 ) and activity-regulated cytoskeleton-associated protein ( Arc ), a validated downstream target of Egr3 [1-3]...
June 2024: Data in Brief
#33
JOURNAL ARTICLE
Kavin Teenakul, Sayed Ali Ahmad Alem, Ritambhara Gond, Anupma Thakur, Babak Anasori, Amirreza Khataee
One of the significant challenges of vanadium redox flow batteries is connected to the negative electrode where the main reaction of V(ii)/V(iii) and the side reaction of hydrogen evolution compete. To address this issue, we used titanium carbide (Ti3 C2 T x ) MXene coating via drop-casting to introduce oxygen functional groups and metals on the carbon electrode surface. Characterization through scanning electron microscopy and X-ray photoelectron spectroscopy confirmed the even distribution of Ti3 C2 T x MXene on the electrodes and the presence of titanium and termination groups (-O, -Cl, and -F)...
April 16, 2024: RSC Advances
#34
Yuyang Chen, Ruebena Dawes, Hyung Chul Kim, Sarah L Stenton, Susan Walker, Alicia Ljungdahl, Jenny Lord, Vijay S Ganesh, Jialan Ma, Alexandra C Martin-Geary, Gabrielle Lemire, Elston N D'Souza, Shan Dong, Jamie M Ellingford, David R Adams, Kirsten Allan, Madhura Bakshi, Erin E Baldwin, Seth I Berger, Jonathan A Bernstein, Natasha J Brown, Lindsay C Burrage, Kimberly Chapman, Alison G Compton, Chloe A Cunningham, Precilla D'Souza, Emmanuèle C Délot, Kerith-Rae Dias, Ellen R Elias, Carey-Anne Evans, Lisa Ewans, Kimberly Ezell, Jamie L Fraser, Lyndon Gallacher, Casie A Genetti, Christina L Grant, Tobias Haack, Alma Kuechler, Seema R Lalani, Elsa Leitão, Anna Le Fevre, Richard J Leventer, Jan E Liebelt, Paul J Lockhart, Alan S Ma, Ellen F Macnamara, Taylor M Maurer, Hector R Mendez, Stephen B Montgomery, Marie-Cécile Nassogne, Serena Neumann, Melanie O'Leary, Elizabeth E Palmer, John Phillips, Georgia Pitsava, Ryan Pysar, Heidi L Rehm, Chloe M Reuter, Nicole Revencu, Angelika Riess, Rocio Rius, Lance Rodan, Tony Roscioli, Jill A Rosenfeld, Rani Sachdev, Cas Simons, Sanjay M Sisodiya, Penny Snell, Laura St Clair, Zornitza Stark, Tiong Yang Tan, Natalie B Tan, Suzanna El Temple, David R Thorburn, Cynthia J Tifft, Eloise Uebergang, Grace E VanNoy, Eric Vilain, David H Viskochil, Laura Wedd, Matthew T Wheeler, Susan M White, Monica Wojcik, Lynne A Wolfe, Zoe Wolfenson, Changrui Xiao, David Zocche, John L Rubenstein, Eirene Markenscoff-Papadimitriou, Sebastian M Fica, Diana Baralle, Christel Depienne, Daniel G MacArthur, Joanna Mm Howson, Stephan J Sanders, Anne O'Donnell-Luria, Nicola Whiffin
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed after comprehensive genetic testing, primarily of protein-coding genes 1 . Increasingly, large genome-sequenced cohorts are improving our ability to discover new diagnoses in the non-coding genome. Here, we identify the non-coding RNA RNU4-2 as a novel syndromic NDD gene. RNU4-2 encodes the U4 small nuclear RNA (snRNA), which is a critical component of the U4/U6.U5 tri-snRNP complex of the major spliceosome 2 . We identify an 18 bp region of RNU4-2 mapping to two structural elements in the U4/U6 snRNA duplex (the T-loop and Stem III) that is severely depleted of variation in the general population, but in which we identify heterozygous variants in 119 individuals with NDD...
April 9, 2024: medRxiv
#35
JOURNAL ARTICLE
Katheryn A Q Cousins, Jeffrey S Phillips, Sandhitsu R Das, Kyra O'Brien, Thomas F Tropea, Alice Chen-Plotkin, Leslie M Shaw, Ilya M Nasrallah, Dawn Mechanic-Hamilton, Corey T McMillan, David J Irwin, Edward B Lee, David A Wolk
INTRODUCTION: We investigate pathological correlates of plasma phosphorylated tau 181 (p-tau181 ), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) across a clinically diverse spectrum of neurodegenerative disease, including normal cognition (NormCog) and impaired cognition (ImpCog). METHODS: Participants were NormCog (n = 132) and ImpCog (n = 461), with confirmed β-amyloid (Aβ+/-) status (cerebrospinal fluid, positron emission tomography, autopsy) and single molecule array plasma measurements...
April 21, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#36
JOURNAL ARTICLE
Y M Zhao, W H Wang, W Zhang, L Wang, S Li, J W Wang, L E Liao, G Y Yu, Z Sun, Y L Qu, Y Gong, Y Lu, T Wu, Y F Li, Q Wang, G H Zhao, Y Xiao, P R Ding, Z Zhang, A W Wu
Objective: To report the long-term outcomes of Chinese rectal cancer patients after adopting a Watch and Wait (W&W) strategy following neoadjuvant therapy (NAT). Methods: This multicenter, cross-sectional study was based on real-world data. The study cohort comprised rectal cancer patients who had achieved complete or near complete clinical responses (cCRs, near-cCRs) after NAT and were thereafter managed by a W&W approach, as well as a few patients who had achieved good responses after NAT and had then undergone local excision for confirmation of pathological complete response...
April 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
#37
JOURNAL ARTICLE
James H Paxton, Kevin J Keenan, John M Wilburn, Stefanie L Wise, Howard A Klausner, Matthew T Ball, Robert B Dunne, K Derek Kreitel, Larry F Morgan, William D Fales, Debbie Madhok, Nobl Barazangi, Steven T McLean, Katherine Cross, Lisa Distenfield, Jordan Sykes, Paul Lovoi, Beth Johnson, Wade S Smith
BACKGROUND: Large-vessel occlusion (LVO) stroke represents one-third of acute ischemic stroke (AIS) in the United States but causes two-thirds of poststroke dependence and >90% of poststroke mortality. Prehospital LVO stroke detection permits efficient emergency medical systems (EMS) transport to an endovascular thrombectomy (EVT)-capable center. Our primary objective was to determine the feasibility of using a cranial accelerometry (CA) headset device for prehospital LVO stroke detection...
April 21, 2024: Academic Emergency Medicine
#38
JOURNAL ARTICLE
S De Vincentis, C Greco, F Fanelli, M C Decaroli, C Diazzi, M Mezzullo, J Milic, M C De Santis, L Roli, U Pagotto, G Guaraldi, V Rochira
PURPOSE: Sex steroids play a key role on male bone homeostasis and body composition (BC), their role in men living with HIV (MLWH) is less recognized. This study aimed at investigating the prevalence of low BMD, sarcopenia, and sarcopenic obesity (SO) and their relationship with sex steroids in MLWH aged < 50. METHODS: Prospective, cross-sectional, observational study on MLWH younger than 50 (median age 47.0 years). BC and BMD were evaluated with DXA...
April 20, 2024: Journal of Endocrinological Investigation
#39
REVIEW
Marcio Y Ferreira, Lucas P Mitre, Anthony E Bishay, Sávio Batista, Lucca B Palavani, Leonardo B Oliveira, Gabriel Semione, Filipi F Andreão, Silvio Porto Junior, Marcelo P Sousa, Pedro G L B Borges, Raphael Camerotte, Raphael Bertani, Michael T Lawton, Eberval G Figueiredo
Brain Arteriovenous Malformations (bAVMs) are rare but high-risk developmental anomalies of the vascular system. Microsurgery through craniotomy is believed to be the mainstay standard treatment for many grades of bAVMs. However, a significant challenge emerges in the existing body of clinical studies on open surgery for bAVMs: the lack of reproducibility and comparability. This study aims to assess the quality of studies reporting clinical and surgical outcomes for bAVMs treated by open surgery and develop a reporting guideline checklist focusing on essential elements to ensure comparability and reproducibility...
April 21, 2024: Neurosurgical Review
#40
JOURNAL ARTICLE
D Adams, P Cintas, G Solé, C Tard, C Labeyrie, A Echaniz-Laguna, C Cauquil, Y Pereon, L Magy, R Juntas Morales, J C Antoine, E Lagrange, P Petiot, M Mallaret, B Francou, A Guiochon-Mantel, A Coste, O Demarcq, C Geffroy, V Famelart, J Rudant, M Bartoli, E Donal, O Lairez, J C Eicher, M Kharoubi, S Oghina, J N Trochu, J Inamo, G Habib, F Roubille, A Hagège, F Morio, E Cariou, J Adda, M S Slama, P Charron, V Algalarrondo, T Damy, S Attarian
OBJECTIVE: We aimed to describe characteristics of patients with ATTR variant polyneuropathy (ATTRv-PN) and ATTRv-mixed and assess the real-world use and safety profile of tafamidis meglumine 20mg. METHODS: Thirty-eight French hospitals were invited. Patient files were reviewed to identify clinical manifestations, diagnostic methods, and treatment compliance. RESULTS: Four hundred and thirteen patients (296 ATTRv-PN, 117 ATTRv-mixed) were analyzed...
April 19, 2024: Revue Neurologique
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