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JOURNAL ARTICLE
D D Cruz Nieto, N E Muguruza Crispin, C M Caira Mamani, H J Castro Bartolomé, M A Inga Sotelo, M N M Alberto, A S Valderrama Romero, V C Vargas Godoy, J M More López, H E Chanducas Tantaleán, N E Menacho Javier, M A Lara Castillo, W Flores Casanova, E R Benavente Ramírez, L A Apolín Montes, F Diestra Salinas
The increase in prices of fertilizers, energy and other materials necessary for the industry triggered a global economic crisis. Reason that was investigated on the biological and chemical characteristics in relation to the yield of radish nourished with humus from plant residue. The objective was to determine the appropriate dose of humus to obtain greater yield and its relationship with the chemical and biological characteristics of the radish. It is based on applied methodology with an experimental approach; Therefore, the Completely Random Block Design model was used, which consisted of 3 blocks and 5 treatments that were T1 with 0, T2 with 4, T3 with 6, T4 with 8 and T5 with 10 t/ha of humus and They applied 15 days after sowing...
2024: Brazilian Journal of Biology
#2
JOURNAL ARTICLE
Alice M Martino, Eric O Yeates, Areg Grigorian, Justine Chinn, Hayley Young, Jessica Colin Escobar, Justin Glavis-Bloom, Arash Anavim, Vahid Yaghmai, Ninh T Nguyen, Matthew Dolich, Sebastian D Schubl, Laura F Goodman, Yigit S Guner, Jeffry Nahmias
Background: Overnight radiology coverage for pediatric trauma patients (PTPs) is addressed with a combination of on-call radiology residents (RRs) and/or attending teleradiologists (ATs); however, the accuracy of these two groups has not been investigated for PTPs. We aimed to compare the accuracy of RRs vs AT interpretations of computed tomography (CT) scans for PTPs. Methods: Pediatric trauma patients (<18 years old) at a single level-I adult/level-II pediatric trauma center were studied in a retrospective analysis (3/2019-5/2020)...
April 24, 2024: American Surgeon
#3
JOURNAL ARTICLE
Leonardo Ortega, Crisleri Carrera, Carolina Muñoz-Flores, Santiago Salazar, Milton F Villegas, María F Starck, Ariel Valenzuela, Niza Agurto, Raquel Montesino, Allisson Astuya, Natalie Parra, Ercilia T Pérez, Natacha Santibáñez, Alex Romero, Pamela Ruíz, Emilio Lamazares, Fátima Reyes, Oliberto Sánchez, Jorge R Toledo, Jannel Acosta
NK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria, fungi, viruses, and parasites. NK-lysin is a type of granulysin, a member of the saposin-like proteins family first isolated from a pig's small intestine. In previous work, for the first time, we identified four variants of nk-lysin from Atlantic salmon ( Salmo salar ) using EST sequences. In the present study, we reported and characterized two additional transcripts of NK-lysin from S. salar . Besides, we evaluated the tissue distribution of three NK-lysins from S...
2024: Frontiers in Immunology
#4
JOURNAL ARTICLE
Guilherme S Lira, Victor A Ota, Mariana Q S Melo, Anna C P Castiñeiras, Isabela C Leitão, Bianca O Silva, Diana Mariani, Cássia C A Gonçalves, Liane J Ribeiro, Marcia Halpern, Thalita F Abreu, Fabiana A Carneiro, Helena T Scheid, Leonardo A V Souza, Débora G M Rodrigues, Nádia V G Cruz, Andrea Cony, Silvia Carvalho, Loyze P O de Lima, Vincent L Viala, Lucio A Caldas, Wanderley de Souza, Luiza M Higa, Carolina M Voloch, Orlando C Ferreira, Clarissa R Damaso, Rafael M Galliez, Débora S Faffe, Amilcar Tanuri, Terezinha M P P Castiñeiras
Mpox is a zoonotic disease historically reported in Africa. Since 2003, limited outbreaks have occurred outside Africa. In 2022, the global spread of cases with sustained interhuman transmission and unusual disease features raised public health concerns. We explore the mpox outbreak in Rio de Janeiro (RJ) state, Brazil, in an observational study of mpox-suspected cases from June to December 2022. Data collection relied on a public healthcare notification form. Diagnosis was determined by MPXV-PCR. In 46 confirmed cases, anti-OPXV IgG was determined by ELISA, and seven MPXV genomes were sequenced...
May 2024: Journal of Medical Virology
#5
JOURNAL ARTICLE
Maíra C Scarpelli, João G A Bergamasco, Joshua S Godwin, Paulo H C Mesquita, Talisson S Chaves, Deivid G Silva, Diego Bittencourt, Nathalia F Dias, Ricardo A Medalha Junior, Paulo C Carello Filho, Vitor Angleri, Luiz A R Costa, Andreas N Kavazis, Carlos Ugrinowitsch, Michael D Roberts, Cleiton A Libardi
PURPOSE: Resistance training (RT) induces muscle growth at varying rates across RT phases, and evidence suggests that the muscle-molecular responses to training bouts become refined or attenuated in the trained state. This study examined how proteolysis-related biomarkers and extracellular matrix (ECM) remodeling factors respond to a bout of RT in the untrained (UT) and trained (T) state. METHODS: Participants (19 women and 19 men) underwent 10 weeks of RT...
April 23, 2024: European Journal of Applied Physiology
#6
JOURNAL ARTICLE
D Martin, F Rödel, S Hehlgans, M Looso, P K Ziegler, M Fleischmann, M Diefenhardt, L Fries, G Kalinauskaite, I Tinhofer, D Zips, C Gani, C Rödel, E Fokas
Anal squamous cell carcinoma (ASCC) is associated with immunosuppression and infection with human papillomavirus (HPV). Response to standard chemoradiotherapy (CRT) varies considerably. A comprehensive molecular characterization of CRT resistance is lacking, and little is known about the interplay between tumor immune contexture, host immunity, and immunosuppressive and/or immune activating effects of CRT. Patients with localized ASCC, treated with CRT at three different sites of the German Cancer Consortium (DKTK) were included...
April 23, 2024: NPJ Precision Oncology
#7
JOURNAL ARTICLE
W S Yiu, T S M Chu, Y Meng, F-M Spring Kong
AIMS: ERCC1 rs11615 and ERCC2 rs238406 single nuclear polymorphism (SNPs) are known for their association with treatment outcome, likely related to radiosensitivity of both tumor and normal tissue in patients with non-small-cell lung cancer. This study aimed to review the effect of 1) these ERCC1/2 SNPs and 2) other SNPs of DNA repair genes on radiation pneumonitis (RP) in patients with lung cancer. MATERIALS AND METHODS: SNPs of our interest included ERCC1 rs11615 and ERCC2 rs238406 and other genes of DNA repair pathways that are functional and biologically active...
March 24, 2024: Clinical Oncology: a Journal of the Royal College of Radiologists
#8
JOURNAL ARTICLE
Junfen Zhang, Celeste M Boesjes, Laura Loman, Esmé Kamphuis, Margreet L E Romeijn, Lotte S Spekhorst, Inge Haeck, Lian F van der Gang, Coco C Dekkers, Lisa P van der Rijst, Albert J Oosting, Paula van Lumig, Anneke M T van Lynden-van Nes, Ron A Tupker, Annieke Nijssen, Annebeth Flinterman, Klaziena Politiek, Wouter R H Touwslager, Wianda A Christoffers, Shiarra M Stewart, Marijke Kamsteeg, Marlies de Graaf, Marjolein S de Bruin-Weller, Marie-Louise A Schuttelaar
BACKGROUND: Long-term daily practice data on patient-reported benefits of dupilumab for atopic dermatitis (AD) remains limited. OBJECTIVE: To evaluate patient-reported outcome measures (PROMs) and the safety of dupilumab in patients with moderate-to-severe AD over a follow-up period of up to 5 years. METHODS: Data were extracted from the prospective, multicenter BioDay registry (October 2017 - 2022) of patients with moderate-to-severe AD treated with dupilumab in daily practice...
April 21, 2024: Journal of the American Academy of Dermatology
#9
JOURNAL ARTICLE
J Remon, E Auclin, L Zubiri, S Schneider, D Rodriguez-Abreu, N Minatta, O Gautschi, F Aboubakar, E Muñoz-Couselo, T Pierret, S I Rothschild, F Cortiula, K L Reynolds, C Thibault, A Gavralidis, N Blais, F Barlesi, D Planchard, B M D Besse
BACKGROUND: Patients with solid organ transplant (SOT) and solid tumors are usually excluded from clinical trials testing immune checkpoint blockers (ICB). As transplant rates are increasing, we aimed to evaluate ICB outcomes in this population, with a special focus on lung cancer. METHODS: We conducted a multicenter retrospective cohort study collecting real data of ICB use in patients with SOT and solid tumors. Clinical data and treatment outcomes were assessed by using retrospective medical chart reviews in every participating center...
April 22, 2024: ESMO Open
#10
JOURNAL ARTICLE
Lora I Dimitrova, Andrew J Lawrence, Eline M Vissia, Sima Chalavi, Andreana F Kakouris, Dick J Veltman, Antje A T S Reinders
INTRODUCTION: Dissociative identity disorder (DID) is characterised by, among others, subjectively reported inter-identity amnesia, reflecting compromised information transfer between dissociative identity states. Studies have found conflicting results regarding memory transfer between dissociative identity states. Here, we investigated inter-identity amnesia in individuals with DID using self-relevant, subject specific stimuli, and behavioural and neural measures. METHODS: Data of 46 matched participants were included; 14 individuals with DID in a trauma-avoidant state, 16 trauma-avoiding DID simulators, and 16 healthy controls...
April 16, 2024: Journal of Psychiatric Research
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JOURNAL ARTICLE
D C Malta, N Romero-Sandoval, L S de M Cardoso, P Arcos, M Gualán, J M Pescarini, E B Brickley, G A Veloso, R T I Bernal, C S Gomes, L R F S Kerr, M Naghavi, P J Cooper, M L Barreto, A H Leyland
OBJECTIVE: This article aims to analyse the evolution of 40 Sustainable Development Goals' (SDGs) health-related indicators in Brazil and Ecuador from 1990 to 2019. STUDY DESIGN: Epidemiological study of long-term trends in 40 SDGs' health-related indicators for Brazil and Ecuador from 1990 to 2019, using estimates from the Global Burden of Disease Study. METHODS: Forty SDGs' health-related indicators and an index from 1990 to 2017 for Brazil and Ecuador, and their projections up to 2030 were extracted from the Institute for Health Metrics and Evaluation's Global Burden of Disease website and analysed...
April 22, 2024: Public Health
#12
JOURNAL ARTICLE
Zacchaeus S Ololade, Olayinka F Onifade, John C Eze, Olawumi T Oyebanji, Anikeola C Olaniran, Iyaduni A Anuoluwa, Oluwatope O Idowu, Bessie E Tommy
This study was aimed at investigating the ability of extract of Annona muricata (AM) flower-petals in ameliorating the toxic effects of acetaminophen on the kidneys of albino rats. The biochemical results showed a marked increase in AM 200 mg (32.84 ± 0.14) and AM 400 mg (32.64 ± 0.78). Increase levels of total protein in AM 200 mg (77.00 ± 5.65) displays nephroprotective potential of the flower extract. Reduction of renal activities of serum urea in AM 400 mg group (6...
April 23, 2024: Natural Product Research
#13
JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
#14
JOURNAL ARTICLE
Ashley M Fuller, Hawley C Pruitt, Ying Liu, Valerie M Irizarry-Negron, Hehai Pan, Hoogeun Song, Ann DeVine, Rohan S Katti, Samir Devalaraja, Gabrielle E Ciotti, Michael V Gonzalez, Erik F Williams, Ileana Murazzi, Dimitris Ntekoumes, Nicolas Skuli, Hakon Hakonarson, Daniel J Zabransky, Jose G Trevino, Ashani Weeraratna, Kristy Weber, Malay Haldar, Joseph A Fraietta, Sharon Gerecht, T S Karin Eisinger-Mathason
CD8+ T cell dysfunction impedes anti-tumor immunity in solid cancers but the underlying mechanisms are diverse and poorly understood. Extracellular matrix (ECM) composition has been linked to impaired T cell migration and enhanced tumor progression; however, impacts of individual ECM molecules on T cell function in the tumor microenvironment (TME) are only beginning to be elucidated. Upstream regulators of aberrant ECM deposition and organization in solid tumors are equally ill-defined. Therefore, we investigated how ECM composition modulates CD8+ T cell function in undifferentiated pleomorphic sarcoma (UPS), an immunologically active desmoplastic tumor...
April 23, 2024: Journal of Clinical Investigation
#15
JOURNAL ARTICLE
Danielle Novetsky Friedman, Joanne F Chou, Jeanne M Clark, Chaya S Moskowitz, Jennifer S Ford, Gregory T Armstrong, Nidha Z Mubdi, Aaron McDonald, Paul C Nathan, Charles A Sklar, Lakshmi V Ramanathan, Leslie L Robison, Kevin C Oeffinger, Emily S Tonorezos
BACKGROUND: Obesity is prevalent in childhood cancer survivors and interacts with cancer treatments to potentiate risk for cardiovascular (CV) death. We tested a remote weight-loss intervention that was effective among adults with CV risk factors in a cohort of adult survivors of childhood acute lymphoblastic leukemia (ALL) with overweight/obesity. METHODS: In this phase 3 efficacy trial, survivors of ALL enrolled in the Childhood Cancer Survivor Study with body mass index (BMI)≥25 kg/m2 were randomized to a remotely-delivered weight-loss intervention versus self-directed weight loss, stratified by history of cranial radiotherapy (CRT)...
April 23, 2024: Cancer Epidemiology, Biomarkers & Prevention
#16
JOURNAL ARTICLE
Kamila F Lima, Rayanne B S Lima, Victor M T Ruiz, Elizamar R R Mendes, Deyse M A Rocha, Leandro C S Brito, Monyka B L Santos, Luzia C C Ferreira, Maria W G Gaspar, Regina C O Melo, Camila B Dalcin, Lorena P Barbosa
BACKGROUND: Asthma is the most common chronic disease in childhood which accounts for numerous annual hospitalizations due to a lack of management and proper management of the disease. Thus, this study aimed to evaluate the effect of using an educational booklet with or without combination with motivational interviewing (MI) on the self-efficacy of parents/caregivers in the control and management of childhood asthma. METHODS: A clinical trial was carried out with 86 parents/caregivers of children with asthma aged between 2 and 12 years who were followed up in primary health care units from March 2019 to December 2020...
April 2024: International Journal of Community Based Nursing and Midwifery
#17
JOURNAL ARTICLE
Ricardo T Lippke, Elisa R De Conti, Luciana F Hernig, Angélica P Teixeira, Fernando A de Quadros, Aparecida T Fiúza, Juliana B Pereira, Rafael da Rosa Ulguim, David E S N Barcellos, Karine Ludwig Takeuti
Porcine circovirus type 2 (PCV-2) is the agent of one of the most important diseases in the swine industry. Although it has been controlled through vaccination, viremic piglets at birth may represent a risk by reducing vaccination efficacy. Since there are few reports on the viremic status of pre-suckling piglets regarding PCV-2 infection, we assessed the PCV-2 frequency in sows housed in 18 breeding farms with no history of clinical PCVAD in Brazil, using placental umbilical cord serum (PUCS). The selection criteria were: breeding farms with more than 1,000 sows; sows not vaccinated for PCV-2 at least for 2 years prior to the study; farms with no history of PCV-2 clinical disease in the last 12 months; and production systems with a maximum of two sites...
2024: Frontiers in Veterinary Science
#18
JOURNAL ARTICLE
S Rutten, M Hulscher, R E Boeschoten, I Keuning, J F van Eck van der Sluijs, M Rikkers, C den Boer, J Maarseveen, T Olde Hartman, L M Tak
BACKGROUND: In the care of patients with persevering (‘treatment-resistant’) persistant physical symptoms (PPS), problems are common. With this study, we want to identify starting points for improvement of care, including suggestions for the role of mental health care. AIM: Using the profile for persevering PPS we will estimate the prevalence, describe characteristics of this patient group and map problems encountered in their care. METHOD: Online survey in general practitioners (GPs)...
2024: Tijdschrift Voor Psychiatrie
#19
Justin E Juskewitch, Lynne Briggs, Jenna Khan, Patrick C Mathias, Terri S Coyle, Vicki L Courson, James T Hansen, Nageswar Madde, Mandy F O'Leary, Hamilton C Tsang
BACKGROUND: With the widespread adoption of Blood Establishment Computer Systems and other Blood Collection and Transfusion Service (BCTS) clinical information systems (CIS), electronic blood donor, product, and patient data are now routinely required for clinical, regulatory, operational, and quality needs. That data are often not readily accessible for such secondary use within CIS databases, particularly for applications with significant data availability requirements such as machine learning and artificial intelligence...
April 22, 2024: Transfusion
#20
JOURNAL ARTICLE
S Y Wang, S J Zhang, H F Meng, H Q Xu, Z X Guo, J F Yan, J L Gao, L N Niu, S L Wang, K Jiao
BACKGROUND: Oral submucous fibrosis (OSF) is a precancerous lesion characterized by fibrous tissue deposition, the incidence of which correlates positively with the frequency of betel nut chewing. Prolonged betel nut chewing can damage the integrity of the oral mucosal epithelium, leading to chronic inflammation and local immunological derangement. However, currently, the underlying cellular events driving fibrogenesis and dysfunction are incompletely understood, such that OSF has few treatment options with limited therapeutic effectiveness...
April 23, 2024: Stem Cell Research & Therapy
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