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https://www.readbyqxmd.com/read/29774854/marburg-virus-infection-in-egyptian-rousette-bats-south-africa-2013-2014-1
#1
Janusz T Pawęska, Petrus Jansen van Vuren, Alan Kemp, Nadia Storm, Antoinette A Grobbelaar, Michael R Wiley, Gustavo Palacios, Wanda Markotter
We detected a high seroprevalence of Marburg virus (MARV) antibodies in fruit bats in South Africa; 19.1% of recaptured bats seroconverted. The MARV RNA isolated closely resembled the 1975 Ozolin strain. These findings indicate endemic MARV circulation in bats in South Africa and should inform policies on MARV disease risk reduction.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29768251/balo-s-concentric-sclerosis-an-update-and-comprehensive-literature-review
#2
Ali Amini Harandi, Akram Esfandani, Hossein Pakdaman, Mehdi Abbasi, Mohammad Ali Sahraian
Balo's concentric sclerosis (BCS) is considered a variant of multiple sclerosis characterized by concentric lamella of alternating demyelinated and partially myelinated tissues. It is a rare and a relatively acute condition. Attacks may proceed rapidly over weeks or months, typically without remission, like Marburg's variant, resulting in death or severe disability. However, the majority of cases have a more benign, self-limiting course with spontaneous remission. Magnetic resonance imaging is a primary imaging modality in the diagnosis of BCS...
May 16, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29725132/post-exposure-treatments-for-ebola-and-marburg-virus-infections
#3
Robert W Cross, Chad E Mire, Heinz Feldmann, Thomas W Geisbert
This corrects the article DOI: 10.1038/nrd.2017.251.
May 4, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29719780/establishment-of-pseudovirus-infection-mouse-models-for-in-vivo-pharmacodynamics-evaluation-of-filovirus-entry-inhibitors
#4
Qing Chen, Ke Tang, Xiaoyu Zhang, Panpan Chen, Ying Guo
Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs. An HIV-based pseudovirus cell infection assay is widely used for viral entry studies in BSL-2 conditions. Here, we successfully constructed nine in vitro pseudo-filovirus models covering all filovirus genera and three in vivo pseudo-filovirus-infection mouse models using Ebola virus, Marburg virus, and Lloviu virus as representative viruses...
March 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29706541/the-egyptian-rousette-genome-reveals-unexpected-features-of-bat-antiviral-immunity
#5
Stephanie S Pavlovich, Sean P Lovett, Galina Koroleva, Jonathan C Guito, Catherine E Arnold, Elyse R Nagle, Kirsten Kulcsar, Albert Lee, Françoise Thibaud-Nissen, Adam J Hume, Elke Mühlberger, Luke S Uebelhoer, Jonathan S Towner, Raul Rabadan, Mariano Sanchez-Lockhart, Thomas B Kepler, Gustavo Palacios
Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals...
April 18, 2018: Cell
https://www.readbyqxmd.com/read/29698959/lectin-affinity-plasmapheresis-for-middle-east-respiratory-syndrome-coronavirus-and-marburg-virus-glycoprotein-elimination
#6
Benjamin Koch, Patricia Schult-Dietrich, Stefan Büttner, Bijan Dilmaghani, Dario Lohmann, Patrick C Baer, Ursula Dietrich, Helmut Geiger
BACKGROUND/AIMS: Middle East respiratory syndrome coronavirus (MERS-CoV) and Marburg virus (MARV) are among the World Health Organization's top 8 emerging pathogens. Both zoonoses share nonspecific early symptoms, a high lethality rate, and a reduced number of specific treatment options. Therefore, we evaluated extracorporeal virus and glycoprotein (GP) elimination by lectin affinity plasmapheresis (LAP). METHODS: For both MERS-CoV (pseudovirus) as well as MARV (GPs), 4 LAP devices (Mini Hemopurifiers, Aethlon Medical, San Diego, CA, USA) and 4 negative controls were tested...
April 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/29685158/ebolavirus-diagnosis-made-simple-comparable-and-faster-than-molecular-detection-methods-preparing-for-the-future
#7
Ameh S James, Shawn Todd, Nina M Pollak, Glenn A Marsh, Joanne Macdonald
BACKGROUND: The 2014/2015 Ebolavirus outbreak resulted in more than 28,000 cases and 11,323 reported deaths, as of March 2016. Domestic transmission of the Guinea strain associated with the outbreak occurred mainly in six African countries, and international transmission was reported in four countries. Outbreak management was limited by the inability to rapidly diagnose infected cases. A further fifteen countries in Africa are predicted to be at risk of Ebolavirus outbreaks in the future as a consequence of climate change and urbanization...
April 23, 2018: Virology Journal
https://www.readbyqxmd.com/read/29673573/atypical-inflammatory-demyelinating-lesions-and-atypical-multiple-sclerosis
#8
REVIEW
X Ayrignac, C Carra-Dallière, P Labauge
Atypical idiopathic inflammatory demyelinating disorders (IIDDs) of the brain have long been known to be disorders closely related to multiple sclerosis (MS), despite having distinctive clinical and radiological characteristics. Originally, they mostly corresponded to acute-onset variants of MS that classically had poor prognoses, such as Baló's concentric sclerosis, Marburg variant of MS and Schilder's disease, and their relationship with MS was based on their shared pathological findings and the co-occurrence of these variants in patients with typical MS...
April 16, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29584652/identification-of-ellagic-acid-from-plant-rhodiola-rosea-l-as-an-anti-ebola-virus-entry-inhibitor
#9
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A Davey, Han Cheng, Lijun Rong
The recent 2014-2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available for the prevention and treatment. Traditional Chinese medicines (TCMs) represent a huge reservoir of bioactive chemicals and many TCMs have been shown to have antiviral activities. 373 extracts from 128 TCMs were evaluated using a high throughput assay to screen for inhibitors of Ebola virus cell entry...
March 27, 2018: Viruses
https://www.readbyqxmd.com/read/29556997/-medical-complications-in-patients-with-neurocognitive-disorders
#10
REVIEW
W Hewer, Bernd Tomandl, Christian Marburger
No abstract text is available yet for this article.
March 2018: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29554213/scotch-subtype-a-coreceptor-tropism-classification-in-hiv-1
#11
Hannah F Löchel, Mona Riemenschneider, Dmitrij Frishman, Dominik Heider
Motivation: The V3 loop of the gp120 glycoprotein of the Human Immunodeficiency Virus 1 (HIV-1) is considered to be responsible for viral coreceptor tropism. gp120 interacts with the CD4 receptor of the host cell and subsequently V3 binds either CCR5 or CXCR4. Due to the fact that the CCR5 coreceptor is targeted by entry inhibitors, a reliable prediction of the coreceptor usage of HIV-1 is of great interest for antiretroviral therapy. Although several methods for the prediction of coreceptor tropism are available, almost all of them have been developed based on only subtype B sequences, and it has been shown in several studies that the prediction of non-B sequences, in particular subtype A sequences, are less reliable...
March 15, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29551136/filoviruses-ecology-molecular-biology-and-evolution
#12
Jackson Emanuel, Andrea Marzi, Heinz Feldmann
The Filoviridae are a family of negative-strand RNA viruses that include several important human pathogens. Ebola virus (EBOV) and Marburg virus are well-known filoviruses which cause life-threatening viral hemorrhagic fever in human and nonhuman primates. In addition to severe pathogenesis, filoviruses also exhibit a propensity for human-to-human transmission by close contact, posing challenges to containment and crisis management. Past outbreaks, in particular the recent West African EBOV epidemic, have been responsible for thousands of deaths and vaulted the filoviruses into public consciousness...
2018: Advances in Virus Research
https://www.readbyqxmd.com/read/29511143/development-and-characterization-of-a-guinea-pig-model-for-marburg-virus
#13
Gary Wong, Wen-Guang Cao, Shi-Hua He, Zi-Rui Zhang, Wen-Jun Zhu, Estella Moffat, Hideki Ebihara, Carissa Embury-Hyatt, Xiang-Guo Qiu
The Angolan strain of Marburg virus (MARV/Ang) can cause lethal disease in humans with a case fatality rate of up to 90%, but infection of immunocompetent rodents do not result in any observable symptoms. Our previous work includes the development and characterization of a MARV/Ang variant that can cause lethal disease in mice (MARV/Ang-MA), with the aim of using this tool to screen for promising prophylactic and therapeutic candidates. An intermediate animal model is needed to confirm any findings from mice studies before testing in the gold-standard non-human primate (NHP) model...
January 18, 2018: Zoological Research
https://www.readbyqxmd.com/read/29500574/-refeeding-syndrome-pathophysiology-risk-factors-prevention-and-treatment
#14
REVIEW
R Wirth, R Diekmann, G Janssen, O Fleiter, L Fricke, A Kreilkamp, M K Modreker, C Marburger, S Nels, M Pourhassan, R Schaefer, H-P Willschrei, D Volkert
Refeeding syndrome is a life-threatening complication that may occur after initiation of nutritional therapy in malnourished patients, as well as after periods of fasting and hunger. Refeeding syndrome can be effectively prevented and treated if its risk factors and pathophysiology are known. The initial measurement of thiamine level and serum electrolytes, including phosphate and magnesium, their supplementation if necessary, and a slow increase in nutritional intake along with close monitoring of serum electrolytes play an important role...
April 2018: Der Internist
https://www.readbyqxmd.com/read/29500195/design-and-evaluation-of-bi-and-trispecific-antibodies-targeting-multiple-filovirus-glycoproteins
#15
Elisabeth K Nyakatura, Samantha E Zak, Anna Z Wec, Daniel Hofmann, Sergey Shulenin, Russell R Bakken, M Javad Aman, Kartik Chandran, John M Dye, Jonathan R Lai
Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These pathogens cause a rapidly progressing and severe viral disease with high mortality rates (generally 30-90%). Outbreaks of filovirus disease are sporadic and, until recently, were limited to less than 500 cases. However, the 2013-2016 epidemic in western Africa, caused by Ebola virus (EBOV), illustrated the potential of filovirus outbreaks to escalate to a much larger scale (over 28,000 suspected cases). mAbs against the envelope glycoprotein represent a promising therapeutic platform for managing filovirus infections...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29494844/discovery-and-evolution-of-aloperine-derivatives-as-novel-anti-filovirus-agents-through-targeting-entry-stage
#16
Xin Zhang, Qiang Liu, Na Zhang, Qian-Qian Li, Zhan-Dong Liu, Ying-Hong Li, Li-Mei Gao, You-Chun Wang, Hong-Bin Deng, Dan-Qing Song
Preventing filoviruses in the entry stage is an attractive antiviral strategy. Taking aloperine, a Chinese natural herb with an endocyclic skeleton, as the lead, 23 new aloperine derivatives were synthesized and evaluated for their anti-filovirus activities including ebola virus (EBOV) and marburg virus (MARV) using pseudotyped virus model. Structure-activity relationship (SAR) analysis indicated that the introduction of a 12N-dichlorobenzyl group was beneficial for the potency. Compound 2e exhibited the most potent anti-EBOV and anti-MARV effects both in vitro and in vivo...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29484344/prevalence-of-risk-factors-for-the-refeeding-syndrome-in-older-hospitalized-patients
#17
M Pourhassan, I Cuvelier, I Gehrke, C Marburger, M K Modreker, D Volkert, H P Willschrei, R Wirth
OBJECTIVES: The incidence of refeeding syndrome (RFS) in older patients is not well-known. The aim of the study was to determine the prevalence of known risk factors for RFS in older individuals during hospitalization at geriatric hospital departments. DESIGN AND SETTING: 342 consecutive older participants (222 females) who admitted at acute geriatric hospital wards were included in a cross-sectional study. We applied the National Institute for Health and Clinical Excellence (NICE) criteria for determining patients at risk of RFS...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29475254/engineering-equations-for-characterizing-non-linear-laser-intensity-propagation-in-air-with-loss
#18
Thomas Karr, Larry B Stotts, Jason A Tellez, Jason D Schmidt, Justin D Mansell
The propagation of high peak-power laser beams in real atmospheres will be affected at long range by both linear and nonlinear effects contained therein. Arguably, J. H. Marburger is associated with the mathematical characterization of this phenomenon. This paper provides a validated set of engineering equations for characterizing the self-focusing distance from a laser beam propagating through non-turbulent air with, and without, loss as well as three source configurations: (1) no lens, (2) converging lens and (3) diverging lens...
February 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29462200/a-prophylactic-multivalent-vaccine-against-different-filovirus-species-is-immunogenic-and-provides-protection-from-lethal-infections-with-ebolavirus-and-marburgvirus-species-in-non-human-primates
#19
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn
The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections. A good prophylactic vaccine should be able to provide protection to all known filovirus species and as an upside potentially protect from newly emerging virus strains. We investigated the immunogenicity and protection elicited by multivalent vaccines expressing glycoproteins (GP) from Ebola virus (EBOV), Sudan virus (SUDV), Taï Forest virus (TAFV) and Marburg virus (MARV)...
2018: PloS One
https://www.readbyqxmd.com/read/29457711/small-animal-models-for-evaluating-filovirus-countermeasures
#20
Logan Banadyga, Gary Wong, Xiangguo Qiu
The development of novel therapeutics and vaccines to treat or prevent disease caused by filoviruses, such as Ebola and Marburg viruses, depends on the availability of animal models that faithfully recapitulate clinical hallmarks of disease as it is observed in humans. In particular, small animal models (such as mice and guinea pigs) are historically and frequently used for the primary evaluation of antiviral countermeasures, prior to testing in nonhuman primates, which represent the gold-standard filovirus animal model...
February 26, 2018: ACS Infectious Diseases
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