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https://www.readbyqxmd.com/read/28906363/predictors-of-noninstitutionalized-survival-1-year-after-hip-fracture-a-prospective-observational-study-to-develop-the-marburg-rehabilitation-tool-for-hip-fractures-marthi
#1
Benjamin Buecking, Daphne Eschbach, Matthias Knobe, Ludwig Oberkircher, Monika Balzer-Geldsetzer, Richard Dodel, Robert Sielski, Bettina Doering, Steffen Ruchholtz, Christopher Bliemel
Hip fractures are frequent fractures in geriatric patients. These fractures have great socioeconomic implications because of the significantly higher risk of mortality and institutionalization. The aim of this study was to develop a prognostic tool to predict survival without institutionalization within 1 year after hip fracture.A total of 402 hip fracture patients aged >60 years (84% community-dwelling) were included in a prospective observational cohort study. Multiple regression analyses determined independent predictors for noninstitutionalized 1-year survival...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28892520/knowledge-and-attitude-towards-ebola-and-marburg-virus-diseases-in-uganda-using-quantitative-and-participatory-epidemiology-techniques
#2
Luke Nyakarahuka, Eystein Skjerve, Daisy Nabadda, Doreen Chilolo Sitali, Chisoni Mumba, Frank N Mwiine, Julius J Lutwama, Stephen Balinandi, Trevor Shoemaker, Clovice Kankya
BACKGROUND: Uganda has reported five (5) Ebola virus disease outbreaks and three (3) Marburg virus disease outbreaks from 2000 to 2016. Peoples' knowledge and attitude towards Ebola and Marburg virus disease impact on control and prevention measures especially during outbreaks. We describe knowledge and attitude towards Ebola and Marburg virus outbreaks in two affected communities in Uganda to inform future outbreak responses and help in the design of health education and communication messages...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28881271/factor-vii-activating-protease-fsap-regulates-the-expression-of-inflammatory-genes-in-vascular-smooth-muscle-and-endothelial-cells
#3
Kristina Byskov, Thomas Boettger, Paul F Ruehle, Nis Valentin Nielsen, Michael Etscheid, Sandip M Kanse
BACKGROUND AND AIMS: The factor VII activating protease (FSAP) knockout mice have a bigger neointima after vascular injury and a larger infarct volume after stroke. The Marburg I (MI) single nucleotide polymorphism (SNP) in the FSAP-encoding gene is associated with an increased risk of stroke and carotid stenosis in humans. We hypothesize that the regulation of gene expression by FSAP in vascular cells accounts for its vasculo-regulatory properties. METHODS: Vascular smooth muscle cells (VSMC) and endothelial cells (EC) were stimulated with FSAP and a microarray-based expression analysis was performed...
August 25, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28872156/indications-of-cone-beam-ct-in-head-and-neck-imaging-in-children
#4
U Walliczek-Dworschak, I Diogo, L Strack, M Mandapathil, A Teymoortash, J A Werner, C Güldner
For imaging of bony structures, especially for the anterior and lateral skull base in ORL medicine, cone beam computed tomography (CBCT) is an increasingly used alternative to CT, with a lower exposition to plain radiography that makes its use for imaging, particularly in children, very interesting. The aim of this study was to analyse possible indications and settings for CBCT in children and compare them to those of adults. A total of 554 patients (age range 0-18 years, mean age 10.36 years), who underwent CBCT between 01/2004-06/2013 in the ENT department at the university clinic of Marburg were enrolled in this retrospective analysis to evaluate technical parameters and indications...
August 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28854581/unexplained-recurrent-miscarriages-are-associated-with-an-aberrant-sperm-protamine-mrna-content
#5
Nina Rogenhofer, Johannes Ott, Adrian Pilatz, Julia Wolf, Christian J Thaler, Lisa Windischbauer, Undraga Schagdarsurengin, Klaus Steger, Viktoria von Schönfeldt
STUDY QUESTION: Are unexplained recurrent miscarriages associated with abnormal protamine-1 and protamine-2 mRNA levels in spermatozoa? SUMMARY ANSWER: Both protamine-1 and protamine-2 mRNA levels as well as the protamine-1 to protamine-2 mRNA ratio in spermatozoa from men whose female partners experienced two or more consecutive miscarriages were significantly different compared to those from both healthy control men and subfertile couples undergoing IVF/ICSI. WHAT IS KNOWN ALREADY: Aberrant sperm protamine ratios are known to be associated with male-factor infertility...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28821722/egyptian-rousette-bats-maintain-long-term-protective-immunity-against-marburg-virus-infection-despite-diminished-antibody-levels
#6
Amy J Schuh, Brian R Amman, Tara K Sealy, Jessica R Spengler, Stuart T Nichol, Jonathan S Towner
Although bats are natural reservoir hosts for numerous zoonotic viruses, little is known about the long-term dynamics of the host immune response following infection and how these viruses are maintained in nature. The Egyptian rousette bat (ERB) is a known reservoir host for Marburg virus (MARV). Following infection of ERBs with MARV, virus-specific IgG antibodies are induced but rapidly wane and by 3 months post-infection the bats are seronegative. To determine whether reinfection of ERBs plays a role in MARV maintenance, we challenge groups of ERBs that were "naturally" or experimentally infected with MARV 17-24 months prior...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28766193/filovirus-research-how-it-began
#7
Werner Slenczka
The first reported filovirus outbreak occurred in August 1967, when laboratory workers in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia (now Serbia) became infected with an unknown highly pathogenic agent. The disease was characterized by high fever, malaise, rash, hemorrhagic and tetanic manifestations, and high lethality, amounting to 25%. The disease was introduced to Europe by grivets (Chlorocebus aethiops), which were used for biomedical research and vaccine production. The causative agent, Marburg virus, was isolated and identified by scientists of the University of Marburg, Germany in cooperation with specialists for viral electron microscopy at the Bernhard Nocht Institute in Hamburg, Germany...
August 2, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28764429/non-negative-intensity-and-back-calculated-non-negative-intensity-for-analysis-of-directional-structure-borne-sound
#8
Daipei Liu, Zdeněk Havránek, Steffen Marburg, Herwig Peters, Nicole Kessissoglou
Non-negative intensity (NNI) is an approach to identify the surface areas of a structure that contribute to sound power. NNI is evaluated in terms of the acoustic impedance matrix obtained directly at the structural surface and as such can only identify surface contributions to sound power at a far-field receiver surface that fully circumscribes the structure. In contrast, back-calculated NNI is evaluated in terms of the acoustic impedance matrix obtained at a far-field receiver surface, and hence can identify surface contributions to sound power at a far-field receiver surface that does not fully circumscribe the structure...
July 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28750668/from-hybridomas-to-a-robust-microalgal-based-production-platform-molecular-design-of-a-diatom-secreting-monoclonal-antibodies-directed-against-the-marburg-virus-nucleoprotein
#9
Franziska Hempel, Michael Maurer, Björn Brockmann, Christian Mayer, Nadine Biedenkopf, Anne Kelterbaum, Stephan Becker, Uwe G Maier
BACKGROUND: The ideal protein expression system should provide recombinant proteins in high quality and quantity involving low production costs only. However, especially for complex therapeutic proteins like monoclonal antibodies many challenges remain to meet this goal and up to now production of monoclonal antibodies is very costly and delicate. Particularly, emerging disease outbreaks like Ebola virus in Western Africa in 2014-2016 make it necessary to reevaluate existing production platforms and develop robust and cheap alternatives that are easy to handle...
July 27, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28724616/marburg-virus-survivor-immune-responses-are-th1-skewed-with-limited-neutralizing-antibody-responses
#10
Spencer W Stonier, Andrew S Herbert, Ana I Kuehne, Ariel Sobarzo, Polina Habibulin, Chen V Abramovitch Dahan, Rebekah M James, Moses Egesa, Stephen Cose, Julius Julian Lutwama, Leslie Lobel, John M Dye
Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune responses. Immune responses in survivors of Ebola virus (EBOV) and Sudan virus (SUDV) infections have provided the most insight, with T cell responses as well as detailed antibody responses having been characterized. Immune responses to Marburg virus (MARV), however, remain almost entirely uncharacterized...
September 4, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28723972/correction-chaperone-mediated-autophagy-protein-bag3-negatively-regulates-ebola-and-marburg-vp40-mediated-egress
#11
Jingjing Liang, Cari A Sagum, Mark T Bedford, Sachdev S Sidhu, Marius Sudol, Ziying Han, Ronald N Harty
[This corrects the article DOI: 10.1371/journal.ppat.1006132.].
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28706276/kanyawara-virus-a-novel-rhabdovirus-infecting-newly-discovered-nycteribiid-bat-flies-infesting-previously-unknown-pteropodid-bats-in-uganda
#12
Tony L Goldberg, Andrew J Bennett, Robert Kityo, Jens H Kuhn, Colin A Chapman
Bats are natural reservoir hosts of highly virulent pathogens such as Marburg virus, Nipah virus, and SARS coronavirus. However, little is known about the role of bat ectoparasites in transmitting and maintaining such viruses. The intricate relationship between bats and their ectoparasites suggests that ectoparasites might serve as viral vectors, but evidence to date is scant. Bat flies, in particular, are highly specialized obligate hematophagous ectoparasites that incidentally bite humans. Using next-generation sequencing, we discovered a novel ledantevirus (mononegaviral family Rhabdoviridae, genus Ledantevirus) in nycteribiid bat flies infesting pteropodid bats in western Uganda...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28685291/filovirus-strategies-to-escape-antiviral-responses
#13
Judith Olejnik, Adam J Hume, Daisy W Leung, Gaya K Amarasinghe, Christopher F Basler, Elke Mühlberger
This chapter describes the various strategies filoviruses use to escape host immune responses with a focus on innate immune and cell death pathways. Since filovirus replication can be efficiently blocked by interferon (IFN), filoviruses have evolved mechanisms to counteract both type I IFN induction and IFN response signaling pathways. Intriguingly, marburg- and ebolaviruses use different strategies to inhibit IFN signaling. This chapter also summarizes what is known about the role of IFN-stimulated genes (ISGs) in filovirus infection...
July 8, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28659479/crystal-structure-of-the-marburg-virus-nucleoprotein-core-domain-chaperoned-by-a-vp35-peptide-reveals-a-conserved-drug-target-for-filovirus
#14
Tengfei Zhu, Hao Song, Ruchao Peng, Yi Shi, Jianxun Qi, George F Gao
Filovirus nucleoprotein (NP), viral protein 35 (VP35), and polymerase L are essential for viral replication and nucleocapsid formation. Here, we identify a 28-residue peptide (NP binding peptide [NPBP]) from Marburg virus (MARV) VP35 through sequence alignment with previously identified Ebola virus (EBOV) NPBP, which bound to the core region (residues 18 to 344) of the N-terminal portion of MARV NP with high affinity. The crystal structure of the MARV NP core/NPBP complex at a resolution of 2.6 Å revealed that NPBP binds to the C-terminal region of the NP core via electrostatic and nonpolar interactions...
September 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28653188/guide-to-the-correct-use-of-filoviral-nomenclature
#15
Jens H Kuhn
The International Committee on Taxonomy of Viruses (ICTV) currently recognizes three genera and seven species as part of the mononegaviral family Filoviridae. Eight distinct filoviruses (Bundibugyo virus, Ebola virus, Lloviu virus, Marburg virus, Ravn virus, Reston virus, Sudan virus, and Taï Forest virus) have been assigned to these seven species. This chapter briefly summarizes the status quo of filovirus classification and focuses on the importance of differentiating between filoviral species and filoviruses and the correct use of taxonomic and vernacular filovirus names and abbreviations in written and oral discourse...
June 27, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28647292/risk-factors-of-refeeding-syndrome-in-malnourished-older-hospitalized-patients
#16
Maryam Pourhassan, Ingeborg Cuvelier, Ilse Gehrke, Christian Marburger, Mirja Katrin Modreker, Dorothee Volkert, Hans-Peter Willschrei, Rainer Wirth
BACKGROUND & AIMS: Despite the high prevalence of malnutrition among older hospitalized persons, it is unknown how many of these malnourished patients are at risk of developing the refeeding syndrome (RFS). In this study, we sought to compare the prevalence and severity of malnutrition among older hospitalized patients with prevalence of known risk factors of RFS. METHODS: This cross-sectional multicenter-study investigated older participants who were consecutively admitted to the geriatric acute care ward...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28645623/identification-of-a-coumarin-based-antihistamine-like-small-molecule-as-an-anti-filoviral-entry-inhibitor
#17
Han Cheng, Adam Schafer, Veronica Soloveva, Dima Gharaibeh, Tara Kenny, Cary Retterer, Rouzbeh Zamani, Sina Bavari, Norton P Peet, Lijun Rong
Filoviruses, consisting of Ebola virus, Marburg virus and Cuevavirus, cause severe hemorrhagic fevers in humans with high mortality rates up to 90%. Currently, there is no approved vaccine or therapy available for the prevention and treatment of filovirus infection in humans. The recent 2013-2015 West African Ebola epidemic underscores the urgency to develop antiviral therapeutics against these infectious diseases. Our previous study showed that GPCR antagonists, particularly histamine receptor antagonists (antihistamines) inhibit Ebola and Marburg virus entry...
September 2017: Antiviral Research
https://www.readbyqxmd.com/read/28636653/the-ebola-virus-vp35-protein-binds-viral-immunostimulatory-and-host-rnas-identified-through-deep-sequencing
#18
Kari A Dilley, Alexander A Voorhies, Priya Luthra, Vinita Puri, Timothy B Stockwell, Hernan Lorenzi, Christopher F Basler, Reed S Shabman
Ebola virus and Marburg virus are members of the Filovirdae family and causative agents of hemorrhagic fever with high fatality rates in humans. Filovirus virulence is partially attributed to the VP35 protein, a well-characterized inhibitor of the RIG-I-like receptor pathway that triggers the antiviral interferon (IFN) response. Prior work demonstrates the ability of VP35 to block potent RIG-I activators, such as Sendai virus (SeV), and this IFN-antagonist activity is directly correlated with its ability to bind RNA...
2017: PloS One
https://www.readbyqxmd.com/read/28622346/flavivirus-and-filovirus-evoprinters-new-alignment-tools-for-the-comparative-analysis-of-viral-evolution
#19
Thomas Brody, Amarendra S Yavatkar, Dong Sun Park, Alexander Kuzin, Jermaine Ross, Ward F Odenwald
BACKGROUND: Flavivirus and Filovirus infections are serious epidemic threats to human populations. Multi-genome comparative analysis of these evolving pathogens affords a view of their essential, conserved sequence elements as well as progressive evolutionary changes. While phylogenetic analysis has yielded important insights, the growing number of available genomic sequences makes comparisons between hundreds of viral strains challenging. We report here a new approach for the comparative analysis of these hemorrhagic fever viruses that can superimpose an unlimited number of one-on-one alignments to identify important features within genomes of interest...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28618802/non-negative-intensity-for-coupled-fluid-structure-interaction-problems-using-the-fast-multipole-method
#20
Daniel R Wilkes, Herwig Peters, Paul Croaker, Steffen Marburg, Alec J Duncan, Nicole Kessissoglou
The non-negative intensity (NNI) method is applied to large-scale coupled fluid-structure interaction (FSI) problems using the fast multipole boundary element method (FMBEM). The NNI provides a field on the radiating structure surface that consists of positive-only contributions to the radiated sound power, thus avoiding the near-field cancellation effects that otherwise occur with the sound intensity field. Thus far the NNI has been implemented with the boundary element method (BEM) for relatively small problem sizes to allow for the full BEM coefficient and inverse matrices to be explicitly constructed and stored...
June 2017: Journal of the Acoustical Society of America
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