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https://www.readbyqxmd.com/read/28701331/lassa-fever
#1
REVIEW
Catherine Houlihan, Ron Behrens
No abstract text is available yet for this article.
July 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28690743/-knowledge-and-attitudes-of-community-volunteers-on-lassa-and-ebola-viral-haemorrhagic-fevers-in-the-donga-department-north-benin
#2
Cossi Angelo Attinsounon, Cossi Athanase Hounnankan, Comlan Albert Dovonou, Cossi Adébayo Alassani, Sourakatou Salifou
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28686227/human-antibody-pieces-together-the-puzzle-of-the-trimeric-lassa-virus-surface-antigen
#3
Antra Zeltina, Thomas A Bowden
No abstract text is available yet for this article.
July 6, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28679759/mutational-analysis-of-lassa-virus-glycoprotein-highlights-regions-required-for-alpha-dystroglycan-utilization
#4
Marissa Acciani, Jacob T Alston, Guohui Zhao, Hayley Reynolds, Afroze M Ali, Brian Xu, Melinda A Brindley
Lassa virus (LASV) is an enveloped RNA virus endemic to West Africa and responsible for severe cases of hemorrhagic fever. Virus entry is mediated by the glycoprotein complex consisting of a stable signal peptide, a receptor-binding subunit GP1, and a viral-host membrane fusion subunit GP2. Several cellular receptors can interact with the GP1 subunit and mediate viral entry, including alpha-dystroglycan (αDG) and lysosomal associated membrane protein 1 (LAMP1). In order to define the regions within GP1 that interact with the cellular receptors, we implemented insertional mutagenesis, carbohydrate shielding, and alanine scanning mutagenesis...
July 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28671959/prevalence-of-lassa-virus-disease-lvd-in-nigerian-children-with-fever-or-fever-and-convulsions-in-an-endemic-area
#5
Odigie C Akhuemokhan, Rosemary O Ewah-Odiase, Nosa Akpede, Jacqueline Ehimuan, Donatus I Adomeh, Ikpomwonsa Odia, Sylvia C Olomu, Meike Pahlmann, Beate Becker-Ziaja, Christian T Happi, Danny A Asogun, Sylvanus A Okogbenin, Peter O Okokhere, Osagie S Dawodu, Irekpono U Omoike, Pardis C Sabeti, Stephan Günther, George O Akpede
BACKGROUND: Convulsions with fever in children are a common neurologic emergency in the tropics, and determining the contribution of endemic viral infections can be challenging. In particular, there is a dearth of data on the prevalence and clinical differentiation of Lassa virus disease (LVD) in febrile children in endemic areas of Nigeria, which has multiple lineages of the virus. The aim of this study was to determine the prevalence and presentation of LVD in febrile children with and without convulsions...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28638939/-consequences-of-autopsies-for-the-living-causes-of-death-in-the-clinical-diagnosis-septic-and-toxic-shock
#6
REVIEW
L Ozretić, A Schwindowski, H-P Dienes, R Büttner, U Drebber, J W U Fries
BACKGROUND: There is reason to believe that the diagnosis of septic and toxic shock, as indicated on the death certificate, cannot be confirmed as the cause of death without autopsy and subsequent histological analysis. The external examination of the corpse can therefore not represent the sole basis for a reliable statement about the infection status of a corpse, e. g. as a prerequisite for embalming. MATERIAL AND METHODS: The validity of autopsy in determining septic and toxic shock as the cause of death is demonstrated in 7 exemplary cases...
June 21, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28584177/structural-drivers-of-vulnerability-to-zoonotic-disease-in-africa
#7
Vupenyu Dzingirai, Salome Bukachi, Melissa Leach, Lindiwe Mangwanya, Ian Scoones, Annie Wilkinson
This paper argues that addressing the underlying structural drivers of disease vulnerability is essential for a 'One Health' approach to tackling zoonotic diseases in Africa. Through three case studies-trypanosomiasis in Zimbabwe, Ebola and Lassa fever in Sierra Leone and Rift Valley fever in Kenya-we show how political interests, commercial investments and conflict and securitization all generate patterns of vulnerability, reshaping the political ecology of disease landscapes, influencing traditional coping mechanisms and affecting health service provision and outbreak responses...
July 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28584172/integrative-modelling-for-one-health-pattern-process-and-participation
#8
REVIEW
I Scoones, K Jones, G Lo Iacono, D W Redding, A Wilkinson, J L N Wood
This paper argues for an integrative modelling approach for understanding zoonoses disease dynamics, combining process, pattern and participatory models. Each type of modelling provides important insights, but all are limited. Combining these in a '3P' approach offers the opportunity for a productive conversation between modelling efforts, contributing to a 'One Health' agenda. The aim is not to come up with a composite model, but seek synergies between perspectives, encouraging cross-disciplinary interactions...
July 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28584171/local-disease-ecosystem-livelihood-dynamics-reflections-from-comparative-case-studies-in-africa
#9
Melissa Leach, Bernard Bett, M Said, Salome Bukachi, Rosemary Sang, Neil Anderson, Noreen Machila, Joanna Kuleszo, Kathryn Schaten, Vupenyu Dzingirai, Lindiwe Mangwanya, Yaa Ntiamoa-Baidu, Elaine Lawson, Kofi Amponsah-Mensah, Lina M Moses, Annie Wilkinson, Donald S Grant, James Koninga
This article explores the implications for human health of local interactions between disease, ecosystems and livelihoods. Five interdisciplinary case studies addressed zoonotic diseases in African settings: Rift Valley fever (RVF) in Kenya, human African trypanosomiasis in Zambia and Zimbabwe, Lassa fever in Sierra Leone and henipaviruses in Ghana. Each explored how ecological changes and human-ecosystem interactions affect pathogen dynamics and hence the likelihood of zoonotic spillover and transmission, and how socially differentiated peoples' interactions with ecosystems and animals affect their exposure to disease...
July 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28572385/structural-basis-for-antibody-mediated-neutralization-of-lassa-virus
#10
Kathryn M Hastie, Michelle A Zandonatti, Lara M Kleinfelter, Megan L Heinrich, Megan M Rowland, Kartik Chandran, Luis M Branco, James E Robinson, Robert F Garry, Erica Ollmann Saphire
The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral surface and the critical target for antibody-mediated neutralization. Here we present the crystal structure of the trimeric, prefusion ectodomain of Lassa GP bound to a neutralizing antibody from a human survivor at 3.2-angstrom resolution. The antibody extensively anchors two monomers together at the base of the trimer, and biochemical analysis suggests that it neutralizes by inhibiting conformational changes required for entry...
June 2, 2017: Science
https://www.readbyqxmd.com/read/28572362/a-step-on-the-path-to-a-lassa-vaccine
#11
EDITORIAL
Valda Vinson
No abstract text is available yet for this article.
June 2, 2017: Science
https://www.readbyqxmd.com/read/28561264/virulence-markers-associated-with-trueperella-pyogenes-infections-in-livestock-and-companion-animals
#12
R M Risseti, E Zastempowska, M Twarużek, H Lassa, J C F Pantoja, A P C de Vargas, S T Guerra, C A D Bolaños, C L de Paula, A C Alves, B S Colhado, F V R Portilho, C Tasca, G H B Lara, M G Ribeiro
Trueperella pyogenes is an opportunistic pathogen that causes diverse pyogenic infections in livestock. The genes that encode the exotoxin pyolysin (plo) and other putative factors that promote adhesion of pathogen to host cells (fimbriae fimA, fimC, fimE, fimG, neuraminidases nanH, nanP, and collagen-binding protein cbpA) have been associated with virulence, particularly in mastitis and uterus infections of dairy cows. However, the role of these virulence markers in the pathogenicity of the agent in domestic animals infections still is incompletely understood...
May 31, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28555386/molecular-pathogenesis-of-viral-hemorrhagic-fever
#13
REVIEW
Christopher F Basler
The clinical syndrome referred to as viral hemorrhagic fever (VHF) can be caused by several different families of RNA viruses, including select members of the arenaviruses, bunyaviruses, filoviruses, and flaviviruses. VHF is characterized by malaise, fever, vascular permeability, decreased plasma volume, coagulation abnormalities, and varying degrees of hemorrhage. Study of the filovirus Ebola virus has demonstrated a critical role for suppression of innate antiviral defenses in viral pathogenesis. Additionally, antigen-presenting cells are targets of productive infection and immune dysregulation...
May 29, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28511600/knowledge-attitude-and-practices-toward-lassa-fever-control-and-prevention-among-residents-of-ile-ife-southwest-nigeria
#14
S A Olowookere, C A Adegbenro, A Idowu, A G Omisore, O M Shabi, U R Ikem, G A Ekwere, I F Oderinde
Lassa fever had been reported as a cause of death especially in endemic parts of Nigeria. This study assessed the knowledge, attitude, and practices toward Lassa fever control and prevention among residents of Ile-Ife, southwest Nigeria. Descriptive cross-sectional study was conducted among consenting randomly selected adults using an interviewer administered questionnaire. Data were analyzed using descriptive and inferential statistics. A total of 400 questionnaires with completed data were analyzed (response rate 96%)...
January 2017: International Quarterly of Community Health Education
https://www.readbyqxmd.com/read/28508222/lassa-virus-reverse-genetics
#15
Luis Martínez-Sobrido, Slobodan Paessler, Juan Carlos de la Torre
The Old World (OW) arenavirus Lassa (LASV ) is estimated to infect several hundred thousand people yearly in West Africa, resulting in high numbers of Lassa fever (LF), a viral hemorrhagic fever (HF) disease associated with high morbidity and mortality. To date, no licensed vaccines are available to LASV infections, and anti-LASV drug therapy is limited to an off-label use of ribavirin (Rib) that is only partially effective. The development of reverse genetics has provided investigators with a novel and powerful approach for the investigation of the molecular, cell biology, and pathogenesis of LASV...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28505171/rapid-deployment-of-a-mobile-biosafety-level-3-laboratory-in-sierra-leone-during-the-2014-ebola-virus-epidemic
#16
Yi Zhang, Yan Gong, Chengyu Wang, Wensen Liu, Zhongyi Wang, Zhiping Xia, Zhaoyang Bu, Huijun Lu, Yang Sun, Xiaoguang Zhang, Yuxi Cao, Fan Yang, Haoxiang Su, Yi Hu, Yongqiang Deng, Bo Zhou, Zongzheng Zhao, Yingying Fu, David Kargbo, Foday Dafae, Brima Kargbo, Alex Kanu, Linna Liu, Jun Qian, Zhendong Guo
BACKGROUND: Ebola virus emerged in West Africa in December 2013. The high population mobility and poor public health infrastructure in this region led to the development of the largest Ebola virus disease (EVD) outbreak to date. METHODOLOGY/PRINCIPAL FINDINGS: On September 26, 2014, China dispatched a Mobile Biosafety Level-3 Laboratory (MBSL-3 Lab) and a well-trained diagnostic team to Sierra Leone to assist in EVD diagnosis using quantitative real-time PCR, which allowed the diagnosis of suspected EVD cases in less than 4 hours from the time of sample receiving...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28498311/differential-immune-responses-to-new-world-and-old-world-mammalian-arenaviruses
#17
REVIEW
Hinh Ly
Some New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans. While these are closely related RNA viruses, the infected hosts appear to mount different types of immune responses against them. Lassa virus (LASV) infection, for example, results in suppressed immune function in progressive disease stage, whereas patients infected with Junín virus (JUNV) develop overt pro-inflammatory cytokine production. These viruses have also evolved different molecular strategies to evade host immune recognition and activation...
May 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28449693/no-measurable-adverse-effects-of-lassa-morogoro-and-gairo-arenaviruses-on-their-rodent-reservoir-host-in-natural-conditions
#18
Joachim Mariën, Benny Borremans, Sophie Gryseels, Barré Soropogui, Luc De Bruyn, Gédéon Ngiala Bongo, Beate Becker-Ziaja, Joëlle Goüy de Bellocq, Stephan Günther, N'Faly Magassouba, Herwig Leirs, Elisabeth Fichet-Calvet
BACKGROUND: In order to optimize net transmission success, parasites are hypothesized to evolve towards causing minimal damage to their reservoir host while obtaining high shedding rates. For many parasite species however this paradigm has not been tested, and conflicting results have been found regarding the effect of arenaviruses on their rodent host species. The rodent Mastomys natalensis is the natural reservoir host of several arenaviruses, including Lassa virus that is known to cause Lassa haemorrhagic fever in humans...
April 27, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28448640/mapping-of-the-lassa-virus-lamp1-binding-site-reveals-unique-determinants-not-shared-by-other-old-world-arenaviruses
#19
Hadar Israeli, Hadas Cohen-Dvashi, Anastasiya Shulman, Amir Shimon, Ron Diskin
Cell entry of many enveloped viruses occurs by engagement with cellular receptors, followed by internalization into endocytic compartments and pH-induced membrane fusion. A previously unnoticed step of receptor switching was found to be critical during cell entry of two devastating human pathogens: Ebola and Lassa viruses. Our recent studies revealed the functional role of receptor switching to LAMP1 for triggering membrane fusion by Lassa virus and showed the involvement of conserved histidines in this switching, suggesting that other viruses from this family may also switch to LAMP1...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28438110/temporal-progression-of-lesions-in-guinea-pigs-infected-with-lassa-virus
#20
T M Bell, C I Shaia, J J Bearss, M E Mattix, K A Koistinen, S P Honnold, X Zeng, C D Blancett, G C Donnelly, J D Shamblin, E R Wilkinson, K A Cashman
Lassa virus (LASV) infection causes an acute, multisystemic viral hemorrhagic fever that annually infects an estimated 100 000 to 300 000 persons in West Africa. This pathogenesis study evaluated the temporal progression of disease in guinea pigs following aerosol and subcutaneous inoculation of the Josiah strain of LASV as well as the usefulness of Strain 13 guinea pigs as an animal model for Lassa fever. After experimental infection, guinea pigs ( Cavia porcellus; n = 67) were serially sampled to evaluate the temporal progression of infection, gross and histologic lesions, and serum chemistry and hematologic changes...
May 2017: Veterinary Pathology
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