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https://www.readbyqxmd.com/read/28750295/effect-of-zearalenone-on-circulating-testosterone-concentration-testicular-and-epididymal-morphology-and-epididymal-sperm-characteristics-in-wild-boars
#1
W Bielas, W Niżański, J Nicpoń, J E Nicpoń, A Partyka, R Mordak, M Nowak, R Ciaputa
This study investigated the effect of exposure to zearalenone (ZEN) and its metabolites on the characteristics of epididymal spermatozoa, testicular and epididymal biometry and histology, and the concentration of testosterone in blood plasma in male wild boars. The study was performed during more than one year on 18 clinically healthy male wild boars with initial and final body weight, of 39 ± 4 kg and 59 ± 3 kg, respectively. The animals were divided into two experimental groups (group I and group II) and one control group (group C) comprising 6 boars per group...
July 18, 2017: Theriogenology
https://www.readbyqxmd.com/read/28750294/freezability-genetics-in-rabbit-semen
#2
R Lavara, E Mocé, M Baselga, J S Vicente
The aim of this study was to estimate the heritability of semen freezability and to estimate the genetic correlation between frozen-thawed sperm traits and the growth rate in a paternal rabbit line. Estimated heritabilities showed that frozen-thawed semen traits are heritable (ranged between 0.08 and 0.15). In the case of Live-FT (percentage of viable sperm after freezing), the estimated heritability is the highest one, and suggests the possibility of effective selection. After the study of genetic correlations it seems that daily weight gain (DG) was negatively correlated with sperm freezability, but no further conclusions could be drawn due to the high HPD95%...
July 17, 2017: Theriogenology
https://www.readbyqxmd.com/read/28749400/a-novel-approach-for-characterizing-variations-in-serum-peptides-in-rheumatic-heart-disease
#3
Xiaochen Wu, Qin Yue, Weikun Jia, Jinbao Zhang, Hui Ouyang, Dong Xin, Yingbin Xiao
BACKGROUND & OBJECTIVES: Acute rheumatic fever and rheumatic heart disease (RHD) are important public health problems in developing countries. In this study, peptidomic analyses on RHD patients and healthy individuals were performed to characterize variations in serum peptide levels using label-free quantitation approaches. METHODS: Blood samples were obtained from 160 healthy controls and 160 RHD patients. Of the 448 identified peptides, 272 were analyzed by two label-free mass spectrometry methods, the spectral count and spectral index...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28749007/reactive-oxygen-species-as-mediators-of-sperm-capacitation-and-pathological-damage
#4
REVIEW
R J Aitken
Oxidative stress plays a major role in the life and death of mammalian spermatozoa. These gametes are professional generators of reactive oxygen species (ROS), which appear to derive from three potential sources: sperm mitochondria, cytosolic L-amino acid oxidases, and plasma membrane nicotinamide adenine dinucleotide phosphate oxidases. The oxidative stress created via these sources appears to play a significant role in driving the physiological changes associated with sperm capacitation through the stimulation of a cyclic adenosine monophosphate/Protein kinase A phosphorylation cascade, including the activation of Extracellular signal regulated kinase-like proteins, massive up-regulation of tyrosine phosphorylation in the sperm tail, as well as the induction of sterol oxidation...
July 27, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28748416/cryoprotective-effect-of-resveratrol-on-dna-damage-and-crucial-human-sperm-messenger-rnas-possibly-through-5-amp-activated-protein-kinase-activation
#5
Maryam Shabani Nashtaei, Saeid Nekoonam, Mohammad Naji, Shabnam Bakhshalizadeh, Fardin Amidi
This work aimed at investigating the effect of resveratrol on (1) DNA integrity and (2) fertilizing capacity of sperm by quantifying the presence of key paternal transcripts considered as markers for male fertility (protamine 1 [PRM1] and protamine 2 [PRM2]) and pregnancy success (adducin 1 alpha [ADD1]) in cryopreserved human spermatozoa through modulation of AMP-activated protein kinase (AMPK). The study populations was drawn from 22 normozoospermic healthy volunteers which were incubated with or without AMPK activator (resveratrol [RSV], 15 µM) or inhibitor (Compound C [CC], 30 µM) for 1 h and were then cryopreserved...
July 26, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28748329/impact-of-thiamethoxam-on-honey-bee-queen-apis-mellifera-carnica-reproductive-morphology-and-physiology
#6
Ivana Tlak Gajger, Martina Sakač, Aleš Gregorc
High honey bee losses around the world have been linked in part by the regular use of neonicotinoids in agriculture. In light of the current situation, the aim of this study was to investigate the effects of thiamethoxam on the development of the reproductive system and physiology in the honey bee queen. Two experimental groups of honey bee queen larvae were treated with thiamethoxam during artificial rearing, applied via artificial feed in two cycles. In the first rearing cycle, honey bee larvae received a single treatment dose (4...
July 26, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28747985/comparative-study-of-fertilization-rates-of-c57bl-6nkorl-and-c57bl-6n-mice-obtained-from-two-other-sources
#7
Woo Bin Yun, Hye Ryeong Kim, Ji Eun Kim, Jun Young Choi, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Young Suk Jung, Hyun Keun Song, Joon Young Cho, Kil Soo Kim, Dae Youn Hwang
C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. To compare the fertilization rates of C57BL/6NKorl mice with two commercial C57BL/6N stocks, differences in reproductive organ structures, sperm and egg numbers, fertilization rates, and embryo development rates among C57BL/6NKorl (Korea FDA source), C57BL/6NA (USA source), and C57BL/6NB (Japan source) mice were determined...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28747541/obesity-a-serious-etiologic-factor-for-male-subfertility-in-modern-society
#8
Yue Liu, Zhide Ding
Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder resulting from behavioral, environmental and heritable causes. Such malfunction increases the risk of developing hypertension, diabetes, cardiovascular disease, respiratory problems, osteoarthritis and cancer. Meanwhile, the negative impact of obesity on male reproduction is gradually being recognized. According to clinical investigations and animal experiments, obesity is correlated with reductions in sperm concentration and motility, increases in sperm DNA damage and changes in reproductive hormonal levels...
July 26, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28747474/male-female-relatedness-at-specific-snp-linkage-groups-influences-cryptic-female-choice-in-chinook-salmon-oncorhynchus-tshawytscha
#9
Cornelia Geßner, Sheri L Johnson, Paul Fisher, Shannon Clarke, Kim Rutherford, Jane Symonds, Neil J Gemmell
In a range of taxa, the relatedness between mates influences both pre- and post-mating processes of sexual selection. However, relatively little is known about the genetic loci facilitating such a bias, with the exception of the major histocompatibility complex. Here, we performed tightly controlled replicated in vitro fertilization trials to explore the impact of relatedness on two possible mechanisms of cryptic female choice (CFC) in Chinook salmon (Oncorhynchus tshawytscha). We tested (i) whether relatedness of mates, assessed using 682 single nucleotide polymorphisms (SNPs) on 29 SNP-linkage groups (LGs), biases a male's sperm velocity in ovarian fluid (a parameter previously shown to predict male fertilization success), and (ii) whether relatedness of mates governs fertilization success via other mechanisms, probably via sperm-egg interactions...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28747381/rapid-evolution-of-female-biased-genes-among-four-species-of-anopheles-malaria-mosquitoes
#10
Francesco Papa, Nikolai Windbichler, Robert M Waterhouse, Alessia Cagnetti, Rocco D'Amato, Tania Persampieri, Mara K N Lawniczak, Tony Nolan, Philippos A Papathanos
Understanding how phenotypic differences between males and females arise from the sex-biased expression of nearly identical genomes can reveal important insights into the biology and evolution of a species. Among Anopheles mosquito species, these phenotypic differences include vectorial capacity, as it is only females that blood feed and thus transmit human malaria. Here, we use RNA-seq data from multiple tissues of four vector species spanning the Anopheles phylogeny to explore the genomic and evolutionary properties of sex-biased genes...
July 26, 2017: Genome Research
https://www.readbyqxmd.com/read/28746727/idiopathic-male-infertility-related-to-periodontal-and-caries-status
#11
Nándor Práger, Norbert Pásztor, Ákos Várnagy, Zoltan Kozinszky, Zoltán Baráth, István Gorzó, Márta Radnai
OBJECTIVES: The present study was undertaken to evaluate the possible correlation between the periodontal and dental status and sperm pathology in idiopathic male infertility. METHODS: The periodontal and caries status and semen quality of 199 men presented with unexplained male infertility were examined. Periodontal and dental factors were analyzed by sperm pathology categories. RESULTS: 106 men had normal sperm parameters, whereas 93 men had some type of spermpathology; 27...
July 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28746190/vasa-mrna-ddx4-detection-is-more-specific-than-immunohistochemistry-using-poly-or-monoclonal-antibodies-for-germ-cells-in-the-male-urogenital-tract
#12
Willem P A Boellaard, Hans Stoop, Ad J M Gillis, J Wolter Oosterhuis, Leendert H J Looijenga
VASA, also known as DDX4, is reported to be specifically expressed in cells belonging to the germ cell lineage, both in males and females. Therefore, it could be an informative protein biomarker to be applied on semen to differentiate between obstructive and nonobstructive azoospermia (OA and NOA, respectively). In addition, it could be of value to predict sperm retrieval based on testicular sperm extraction. Immunocytochemistry of proven OA semen using both polyclonal and monoclonal antibodies against VASA showed positive staining of both cells and cell sized particles...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28744698/association-of-basal-serum-androgen-levels-with-ovarian-response-and-icsi-cycle-outcome
#13
C Abide Yayla, E Ozkaya, S Kayatas Eser, I Sanverdi, B Devranoglu, T Kutlu
BACKGROUND: The purpose of this study was to assess the predictive value of basal serum testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) levels during follicular phase for ovarian response and outcome in intracytoplasmic sperm injection (ICSI) cycles of women with diminished ovarian reserve. METHODS: We prospectively gathered data of basal serum androgen levels and ICSI cycle characteristics of 120 women with diminished ovarian reserve. Association of basal serum T and DHEAS levels with ovarian response was analyzed...
July 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28744317/podophyllotoxin-extracted-from-juniperus-sabina-fruit-inhibits-rat-sperm-maturation-and-fertility-by-promoting-epididymal-epithelial-cell-apoptosis
#14
Shuwu Xie, Guoting Li, Lijuan Qu, Ruihua Zhong, Ping Chen, Zhigang Lu, Jieyun Zhou, Xiangjie Guo, Zhao Li, Aying Ma, Yueying Qian, Yan Zhu
This study aimed to investigate the antifertility effect of Juniperus sabina fruit on male rats and its possible mechanism, and hence it might be developed as a potential nonhormonal male contraceptive. Male rats were intragastrically fed for consecutive 8-week and 4-week recovery with the fruit of J. Sabina, and sperm maturation, serum testosterone level, and histopathology were analyzed. Epididymal epithelial cell culture was prepared for detection of podophyllotoxin activities. Furthermore, cell proliferation, transmission electron microscopy, Annexin V/Propidium iodide, TUNEL, RT-PCR, ELISA, and western blotting were examined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28743739/ip6k1-is-essential-for-chromatoid-body-formation-and-temporal-regulation-of-tnp2-and-prm2-expression-in-mouse-spermatids
#15
Aushaq Bashir Malla, Rashna Bhandari
Inositol hexakisphosphate kinases (IP6Ks) are enzymes that synthesise the inositol pyrophosphate 5-IP7, which is known to regulate several physiological processes. Deletion of IP6K1, but not other IP6K isoforms, causes sterility in male mice. Here, we present a detailed investigation of the specific function of IP6K1 in spermatogenesis. Within the mouse testis, IP6K1 is expressed at high levels in late stage pachytene spermatocytes and in round spermatids. We found IP6K1 to be a novel component of the chromatoid body, a cytoplasmic granule in round spermatids composed of RNA and RNA binding proteins, and noted that this structure is absent in Ip6k1(-/-) round spermatids...
July 25, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28743557/a-high-fat-high-protein-diet-attenuates-the-negative-impact-of-casein-induced-chronic-inflammation-on-testicular-steroidogenesis-and-sperm-parameters-in-adult-mice
#16
Jing-Lu Zhao, Yu-Yun Zhao, Wei-Jie Zhu
Theinteractionbetweenobesityandchronicinflammationhasbeenstudied. Diet-induced obesity or chronic inflammation could reduce the testicular functions of males. However, the mechanism underlying the reproductive effects of fattening foods in males with or without chronic inflammation still needs further discussion. This study was aimed to investigate the effects of high-fat, high-protein diet on testicular steroidogenesis and sperm parameters in adult mice under physiological and chronic inflammatory conditions...
July 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28743544/sodium-dependent-organic-anion-transporter-slc10a6-knockout-mice-show-normal-spermatogenesis-and-reproduction-but-elevated-serum-levels-for-cholesterol-sulfate
#17
Katharina Bakhaus, Josefine Bennien, Daniela Fietz, Alberto Sánchez-Guijo, Michaela Hartmann, Rosanna Serafini, Charles C Love, Andrei Golovko, Stefan A Wudy, Martin Bergmann, Joachim Geyer
The sodium-dependent organic anion transporter SOAT (gene name SLC10A6 in man and Slc10a6 in mice) is a plasma membrane transporter for sulfated steroids, which is highly expressed in germ cells of the testis. SOAT can transport biologically inactive sulfated steroids into specific target cells, where they can be reactivated by the steroid sulfatase (STS) to biologically active, unconjugated steroids known to regulate spermatogenesis. Significantly reduced SOAT mRNA expression was previously found in different forms of impaired spermatogenesis in man...
July 22, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28743513/chronic-exposure-to-the-fungicide-propiconazole-behavioral-and-reproductive-evaluation-of-f1-and-f2-generations-of-male-rats
#18
Milene Leivas Vieira, Nathália Orlandini Costa, Marina Rangel F Pereira, Suzana de Fátima Paccola Mesquita, Estefânia Gastaldello Moreira, Daniela Cristina Ceccatto Gerardin
Several studies have suggested that propiconazole (PROP) may be an endocrine disruptor; possibly altering the activity of the CYP51 enzyme, which is part of the cholesterol biosynthesis pathway required for the production of sexual steroid hormones. Another PROP effect is inhibition of the aromatase enzyme that converts androgens into estrogens, which could lead to negative effects on reproductive parameters. Therefore, the present study evaluated the reproductive and developmental toxicity of PROP by exposing two generations (F1 and F2) of male rats to this fungicide, since a previous study from our lab reported that PROP has anti-estrogenic and anti-androgenic activities (Costa et al...
July 22, 2017: Toxicology
https://www.readbyqxmd.com/read/28743233/erratum-to-conserved-gene-expression-in-sperm-reservoirs-between-birds-and-mammals-in-response-to-mating
#19
Mohammad Atikuzzaman, Manuel Alvarez-Rodriguez, Alejandro Vicente-Carrillo, Martin Johnsson, Dominic Wright, Heriberto Rodriguez-Martinez
No abstract text is available yet for this article.
July 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28742876/expression-of-uncharacterized-male-germ-cell-specific-genes-and-discovery-of-novel-sperm-tail-proteins-in-mice
#20
Jun Tae Kwon, Sera Ham, Suyeon Jeon, Youil Kim, Seungmin Oh, Chunghee Cho
The identification and characterization of germ cell-specific genes are essential if we hope to comprehensively understand the mechanisms of spermatogenesis and fertilization. Here, we searched the mouse UniGene databases and identified 13 novel genes as being putatively testis-specific or -predominant. Our in silico and in vitro analyses revealed that the expressions of these genes are testis- and germ cell-specific, and that they are regulated in a stage-specific manner during spermatogenesis. We generated antibodies against the proteins encoded by seven of the genes to facilitate their characterization in male germ cells...
2017: PloS One
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