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https://www.readbyqxmd.com/read/28109900/microcystin-lr-retards-gonadal-maturation-through-disrupting-the-growth-hormone-insulin-like-growth-factors-system-in-zebrafish
#1
Jie Hou, Yujing Su, Wang Lin, Honghui Guo, Ping Xie, Jun Chen, Zemao Gu, Li Li
Recent studies have documented that microcystins (MCs) have potential toxic effects on growth and reproduction in fish. However, no systematic data exist on whether MCs cause gonadal development retardation through disrupting the growth hormone/insulin-like growth factors (GH/IGFs) system. To this end, zebrafish hatchlings (5 d post-fertilization) were exposed to 0, 0.3, 3 and 30µg/L microcystin-LR (MC-LR) for 90 d until they reached sexual maturity. Life-cycle exposure to MC-LR caused delayed ovarian maturation and sperm development along with ultrapathological lesions in the brain and liver...
January 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28109753/using-game-theory-to-investigate-the-epigenetic-control-mechanisms-of-embryo-development-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#2
Le Zhang, Shaoxiang Zhang
A body of research [1-7] has already shown that epigenetic reprogramming plays a critical role in maintaining the normal development of embryos. However, the mechanistic quantitation of the epigenetic interactions between sperms and oocytes and the related impact on embryo development are still not clear [6,7]. In this study, Wang et al., [8] develop a modeling framework that addresses this question by integrating game theory and the latest discoveries of the epigenetic control of embryo development.
January 18, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28109274/the-role-of-fatty-acids-on-icsi-outcomes-a-prospective-cohort-study
#3
Parvaneh Mirabi, Mohammad Javad Chaichi, Sedighe Esmaeilzadeh, Seyed Gholam Ali Jorsaraei, Ali Bijani, Mahjoobeh Ehsani, Seyedeh Fezzeh Hashemi Karooee
BACKGROUND: Our objective was to determine the effect of fatty acids (FAs) in serum and follicular fluid (FF) on fertilization and intracytoplasmic sperm injection (ICSI) outcomes. METHODS: One hundred five women aged 18-38 years undergoing ICSI were recruited in this prospective cohort study. oocyte and emberyo quality was morphologically assessed. FAs in serum and FF were analyzed, using gas chromatography-mass spectrometry (GC-MS). RESULTS: The mean number of mature oocytes was associated with serum levels of oleic acid (r = 0...
January 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28108487/transition-zone-migration-a-mechanism-for-cytoplasmic-ciliogenesis-and-postaxonemal-centriole-elongation
#4
Tomer Avidor-Reiss, Andrew Ha, Marcus L Basiri
The cilium is an elongated and continuous structure that spans two major subcellular domains. The cytoplasmic domain contains a short centriole, which serves to nucleate the main projection of the cilium. This projection, known as the axoneme, remains separated from the cytoplasm by a specialized gatekeeping complex within a ciliary subdomain called the transition zone. In this way, the axoneme is compartmentalized. Intriguingly, however, this general principle of cilium biology is altered in the sperm cells of many animals, which instead contain a cytoplasmic axoneme domain...
January 20, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28108009/which-factors-are-most-predictive-for-live-birth-after-in%C3%A2-vitro-fertilization-and-intracytoplasmic-sperm-injection-ivf-icsi-treatments-analysis-of-100-prospectively-recorded-variables-in-8-400-ivf-icsi-single-embryo-transfers
#5
Katarina Kebbon Vaegter, Tatevik Ghukasyan Lakic, Matts Olovsson, Lars Berglund, Thomas Brodin, Jan Holte
OBJECTIVE: To construct a prediction model for live birth after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment and single-embryo transfer (SET) after 2 days of embryo culture. DESIGN: Prospective observational cohort study. SETTING: University-affiliated private infertility center. PATIENT(S): SET in 8,451 IVF/ICSI treatments in 5,699 unselected consecutive couples during 1999-2014. INTERVENTION(S): A total of 100 basal patient characteristics and treatment data were analyzed for associations with live birth after IVF/ICSI (adjusted for repeated treatments) and subsequently combined for prediction model construction...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28107742/heavy-rare-earth-elements-affect-early-life-stages-in-paracentrotus-lividus-and-arbacia-lixula-sea-urchins
#6
Rahime Oral, Giovanni Pagano, Antonietta Siciliano, Maria Gravina, Anna Palumbo, Immacolata Castellano, Oriana Migliaccio, Philippe J Thomas, Marco Guida, Franca Tommasi, Marco Trifuoggi
BACKGROUND: Heavy rare earth elements (HREEs) have been scarcely studied for their toxicity, in spite of their applications in several technologies. Thus HREEs require timely investigations for their adverse health effects. METHODS: Paracentrotus lividus and Arbacia lixula embryos and sperm were exposed to trichloride salts of five HREEs (Dy, Ho, Er, Yb and Lu) and to Ce(III) as a light REE (LREE) reference to evaluate: 1) developmental defects (% DD) in HREE-exposed larvae or in the offspring of HREE-exposed sperm; 2) mitotic anomalies; 3) fertilization success; and 4) reactive oxygen species (ROS) formation, and nitric oxide (NO) and malondialdehyde (MDA) levels...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28107741/building-related-symptoms-are-linked-to-the-in-vitro-toxicity-of-indoor-dust-and-airborne-microbial-propagules-in-schools-a-cross-sectional-study
#7
J T Salin, M Salkinoja-Salonen, P J Salin, K Nelo, T Holma, P Ohtonen, H Syrjälä
INTRODUCTION: Indoor microbial toxicity is suspected to cause some building-related symptoms, but supporting epidemiological data are lacking. OBJECTIVE: We examined whether the in vitro toxicity of indoor samples from school buildings was associated with work-related health symptoms (building-related symptoms, BRS). METHODS: Administrators of the Helsinki City Real Estate Department selected 15 schools for the study, and a questionnaire on symptoms connected to work was sent to the teachers in the selected schools for voluntary completion...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28107061/the-evolution-of-reproductive-phenology-in-broadcast-spawners-and-the-maintenance-of-sexually-antagonistic-polymorphism
#8
Colin Olito, Dustin J Marshall, Tim Connallon
Reproductive phenology is a crucial life-history trait that evolves in response to external environmental conditions and frequency- and density-dependent interactions within species. Broadcast spawners-which represent a large fraction of aquatic biodiversity-evolve phenologies that balance strong density-dependent fertilization success against abiotic environmental conditions that are required for successful reproduction. The overall balance between these processes may be particularly complex in dioecious species, where selection on reproductive timing potentially differs between the sexes...
February 2017: American Naturalist
https://www.readbyqxmd.com/read/28105298/the-right-to-know-one-s-genetic-origins-and-cross-border-medically-assisted-reproduction
#9
EDITORIAL
Vardit Ravitsky
The use of donor sperm or egg for reproduction raises the issue of the right of donor-conceived individuals to know their genetic origins. This paper argues in favor of acknowledging such a right and explores the challenges that cross-border medically assisted reproduction would raise in relation to it. It first explores possible justifications for such a right by discerning its possible conceptual and empirical groundings. It describes some key ethical and policy implications of the removal of donor anonymity...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28105107/long-time-vs-short-time-insemination-of-sibling-eggs
#10
Jing Liu, Xiao Zhang, Yue Yang, Junliang Zhao, Dayong Hao, Jianrui Zhang, Yanli Liu, Wenbin Wu, Xingling Wang
This study aimed to evaluate the impact of a short insemination procedure on embryo development, assess the reliability of a fertilization check prior to the appearance of pronuclei and elucidate the role of rescue intracytoplasmic sperm injection (R-ICSI). Patients who had ≥9 eggs, were aged <38 years and had normal semen samples were included. The sibling eggs of each patient were divided into two groups; one half for conventional in vitro fertilization (IVF; insemination time, 20 h) and the other half for short insemination (insemination time, 5 h)...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104747/the-goddard-and-saturn-genes-are-essential-for-drosophila-male-fertility-and-may-have-arisen-de-novo
#11
Anna M Gubala, Jonathan F Schmitz, Michael J Kearns, Tery T Vinh, Erich Bornberg-Bauer, Mariana F Wolfner, Geoffrey D Findlay
New genes arise through a variety of mechanisms, including the duplication of existing genes and the de novo birth of genes from non-coding DNA sequences. While there are numerous examples of duplicated genes with important functional roles, the functions of de novo genes remain largely unexplored. Many newly evolved genes are expressed in the male reproductive tract, suggesting that these evolutionary innovations may provide advantages to males experiencing sexual selection. Using testis-specific RNA interference, we screened 11 putative de novo genes in Drosophila melanogaster for effects on male fertility and identified two, goddard and saturn, that are essential for spermatogenesis and sperm function...
January 19, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28104697/male-birthweight-semen-quality-and-birth-outcomes
#12
B W Whitcomb, M S Bloom, S Kim, Z Chen, G M Buck Louis
STUDY QUESTION: What are the relations among birthweight (BW), semen parameters and birth outcomes in a population-based sample? SUMMARY ANSWER: BW is unrelated to semen parameters, which are in turn unrelated to birth outcomes. WHAT IS KNOWN ALREADY: In clinical settings, there has been suggestion that semen parameters are related to BW when comparing fertile and infertile men; however, findings have been less clear in more general populations...
January 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28104696/systematic-characterization-of-human-testis-specific-actin-capping-protein-%C3%AE-3-as-a-possible-biomarker-for-male-infertility
#13
T Soda, Y Miyagawa, N Ueda, K Takezawa, H Okuda, S Fukuhara, K Fujita, H Kiuchi, M Uemura, Y Okamoto, A Tsujimura, H Tanaka, N Nonomura
STUDY QUESTION: Is actin capping protein (CP) β3 involved in human spermatogenesis and male infertility? SUMMARY ANSWER: Human CPβ3 (hCPβ3) is expressed in testis, changes its localization dynamically during spermatogenesis, and has some association with male infertility. WHAT IS KNOWN ALREADY: The testis-specific α subunit of CP (CPα3) was previously identified in human, and mutations in the cpα3 gene in mouse were shown to induce malformation of the sperm head and male infertility...
January 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28104681/copy-number-variations-of-e2f1-a-new-genetic-risk-factor-for-testicular-cancer
#14
Maria Santa Rocca, Andrea Di Nisio, Arianna Marchiori, Marco Ghezzi, Giuseppe Opocher, Carlo Foresta, Alberto Ferlin
Testicular germ cell tumor (TGCT) is one of the most heritable forms of cancer. In last years many evidence suggested that constitutional genetic factors, mainly single nucleotide polymorphisms, can increase its risk. However, the possible contribution of copy-number variations (CNVs) in TGCT susceptibility has not been substantially addressed. Indeed, an increasing number of studies have focused on the effect of CNVs on gene expression and on the role of these structural genetic variations as risk factors for different forms of cancer...
January 19, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28104241/cardiovascular-and-metabolic-profiles-of-offspring-conceived-by-assisted-reproductive-technologies-a-systematic-review-and-meta-analysis
#15
Xiao-Yan Guo, Xin-Mei Liu, Li Jin, Ting-Ting Wang, Kamran Ullah, Jian-Zhong Sheng, He-Feng Huang
OBJECTIVE: To evaluate cardiovascular and metabolic features of offspring conceived by in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI). DESIGN: Literature review and meta-analysis. SETTING: Not applicable. PATIENT(S): Offspring from IVF-ICSI versus natural conception. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Systolic and diastolic blood pressure (SBP and DBP), cardiovascular function, body mass index (BMI), and lipid and glucose profiles...
January 16, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28103141/modification-of-the-genome-of-domestic-animals
#16
Samantha N Lotti, Kathryn M Polkoff, Marcello Rubessa, Matthew B Wheeler
In the past few years, new technologies have arisen that enable higher efficiency of gene editing. With the increase ease of using gene editing technologies, it is important to consider the best method for transferring new genetic material to livestock animals. Microinjection is a technique that has proven to be effective in mice but is less efficient in large livestock animals. Over the years, a variety of methods have been used for cloning as well as gene transfer including; nuclear transfer, sperm mediated gene transfer (SMGT), and liposome-mediated DNA transfer...
January 19, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28103109/impaired-spermatogenesis-in-the-twitcher-mouse-a-morphological-evaluation-from-the-seminiferous-tubules-to-epididymal-transit
#17
Alice Luddi, Martina Gori, Laura Crifasi, Camilla Marrocco, Giuseppe Belmonte, Elvira Costantino-Ceccarini, Piomboni Paola
: Spermatogenesis is a complex process of proliferation and differentiation during male germ cell development whereby undifferentiated spermatogonial germ cells evolve into maturing spermatozoa. In this developmental process the interactions between different cell types are finely regulated, hence any disruption in these relationships leads to male infertility. The twitcher mouse, the murine model of Krabbe disease, is characterized by deficiency of galactosylceramidase, an enzyme also involved in the metabolism of the galactosyl-alkyl-acyl-glycerol, the precursor of sulfogalactosyl-alkyl-acyl-glycerol, the most abundant glycolipid in spermatozoa...
January 19, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28102433/advanced-forensic-validation-for-human-spermatozoa-identification-using-sperm-hy-liter%C3%A2-express-with-quantitative-image-analysis
#18
Ayari Takamura, Ken Watanabe, Tomoko Akutsu
Identification of human semen is indispensable for the investigation of sexual assaults. Fluorescence staining methods using commercial kits, such as the series of SPERM HY-LITER™ kits, have been useful to detect human sperm via strong fluorescence. These kits have been examined from various forensic aspects. However, because of a lack of evaluation methods, these studies did not provide objective, or quantitative, descriptions of the results nor clear criteria for the decisions reached. In addition, the variety of validations was considerably limited...
January 19, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28102396/zinc-sparks-induce-physiochemical-changes-in-the-egg-zona-pellucida-that-prevent-polyspermy
#19
Emily L Que, Francesca E Duncan, Amanda R Bayer, Steven J Philips, Eric W Roth, Reiner Bleher, Sophie C Gleber, Stefan Vogt, Teresa K Woodruff, Thomas V O'Halloran
During fertilization or chemically-induced egg activation, the mouse egg releases billions of zinc atoms in brief bursts known as 'zinc sparks.' The zona pellucida (ZP), a glycoprotein matrix surrounding the egg, is the first structure zinc ions encounter as they diffuse away from the plasma membrane. Following fertilization, the ZP undergoes changes described as 'hardening', which prevent multiple sperm from fertilizing the egg and thereby establish a block to polyspermy. A major event in zona hardening is cleavage of ZP2 proteins by ovastacin; however, the overall physiochemical changes contributing to zona hardening are not well understood...
January 19, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28102039/a-dispermic-chimerism-detected-in-a-taiwanese-potential-unrelated-hematopoietic-stem-cell-donor
#20
E K L Yang, S G E Marsh, P-Y Chen, C-P Chen, S-P Chen, P Y Lin
Chimerism is defined as the presence of 2 or more than 1 genetically distinct cell populations in an organism. Dispermic chimeras are derived from the fertilization of 1 or 2 matured nuclei by 2 sperms. We here report detection of a healthy and phenotypically normal female with normal ABO red blood cell typing in whom dispermic chimerism was suspected after 3 alleles were identified at multiple human leukocyte antigen (HLA) loci using molecular HLA analysis. Molecular HLA typing showed the donor to have 3 HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 alleles in blood, saliva and nail samples...
February 2017: HLA
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