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https://www.readbyqxmd.com/read/29029169/a-family-affair-family-typologies-of-problems-and-midlife-well-being
#1
Karen L Fingerman, Meng Huo, Jamie L Graham, Kyungmin Kim, Kira S Birditt
Background and Objectives: Midlife adults are a "pivot" generation, responding to parents' and grown children's problems. Yet, some midlife adults may have families where multiple members suffer sorrows, whereas other midlife adults may have families with few problems. This study examined: (a) typologies of problems across generations and (b) associations between profiles of problems and midlife adults' well-being. Research Design and Methods: Midlife adults (N = 633) reported their own, each parent's (n = 868), and grown child's (n = 1,785) physical (e...
September 23, 2017: Gerontologist
https://www.readbyqxmd.com/read/29028812/occurrence-of-the-middle-east-respiratory-syndrome-coronavirus-mers-cov-across-the-gulf-corporation-council-countries-four-years-update
#2
Mahmoud Aly, Mohamed Elrobh, Maha Alzayer, Sameera Aljuhani, Hanan Balkhy
The emergence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections has become a global issue of dire concerns. MERS-CoV infections have been identified in many countries all over the world whereas high level occurrences have been documented in the Middle East and Korea. MERS-CoV is mainly spreading across the geographical region of the Middle East, especially in the Arabian Peninsula, while some imported sporadic cases were reported from the Europe, North America, Africa, and lately Asia...
2017: PloS One
https://www.readbyqxmd.com/read/29028576/bioelectrochromic-hydrogel-for-fast-antibiotic-susceptibility-testing
#3
Ferran Pujol-Vila, Jiri Dietvorst, Laura Gall-Mas, María Díaz-González, Núria Vigués, Jordi Mas, Xavier Muñoz-Berbel
Materials science offers new perspectives in the clinical analysis of antimicrobial sensitivity. However, a biomaterial with the capacity to respond to living bacteria has not been developed to date. We present an electrochromic iron(III)-complexed alginate hydrogel sensitive to bacterial metabolism, here applied to fast antibiotic-susceptibility determination. Bacteria under evaluation are entrapped -and pre-concentrated- in the hydrogel matrix by oxidation of iron (II) ions to iron (III) and in situ formation of the alginate hydrogel in less than 2min and in soft experimental conditions (i...
September 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028272/dietary-carbohydrates-components-of-energy-balance-and-associated-health-outcomes
#4
Harry A Smith, Javier T Gonzalez, Dylan Thompson, James A Betts
The role of dietary carbohydrates in the development of obesity and associated metabolic dysfunction has recently been questioned. Within the last decade, the Scientific Advisory Committee on Nutrition carried out a comprehensive evaluation of the role of dietary carbohydrates in human health. The current review aims to complement and extend this report by providing specific consideration of the effects of the component parts of energy balance, their interactions, and their culmination on energy storage and health...
October 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29028074/efficacy-and-safety-of-5-lidocaine-medicated-plasters-in-localized-pain-with-neuropathic-and-or-inflammatory-characteristics-an-observational-real-world-study
#5
F Amato, G Duse, L Consoletti, C Lo Presti, V Firetto, G Ciliberto, L A Parigi, V Palmieri, M Mazza
OBJECTIVE: Based on clinical study results, 5% lidocaine-medicated plaster (5% LMP) is currently recommended for the treatment of localized peripheral neuropathic pain, such as post-herpetic neuralgia (PHN). However, its effective action, as well as the high safety, have indeed led to its use in clinical practice for pain conditions with similar pathophysiological mechanisms. In this study, the efficacy and safety of 5% LMP were investigated in patients with localized pain with neuropathic and/or inflammatory characteristics, such as PHN, post-traumatic/surgical or musculoskeletal pain...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027508/practice-based-small-group-learning-pbsgl-in-scotland-a-survey-of-registered-pharmacy-staff-and-general-practice-nurses
#6
David E Cunningham, Leon Zlotos
INTRODUCTION: Practice-based small group learning (PBSGL) has grown in primary healthcare in Scotland, and is used regularly by 2244 GPs and GP specialist trainees. The programme has been available to general practice nurses (GPNs) and pharmacy staff since uni-professional and inter-professional pilot studies were considered successful. Growth has been slower compared to GPs uptake but has now reached significant levels. It seemed timely to evaluate the use of the programme by these professions...
October 13, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/29027498/relationships-between-presenteeism-and-work-related-musculoskeletal-disorders-among-physical-therapists-in-the-republic-of-korea
#7
Young-Hyeon Bae
This study investigated the relationship between presenteeism and work-related musculoskeletal disorders (WMSDs) among physical therapists (PTs) in the Republic of Korea. Questionnaires were given to 600 PTs in Republic of Korea. General and occupational characteristics and the prevalence of presenteeism and absenteeism were self-reported on the questionnaire. Stepwise regression analyses were used to evaluate the effects of presenteeism and other variables on general and occupational characteristics. Of the 490 PTs who responded, 394 (81...
October 13, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29027004/blood-lymphocyte-subsets-identify-optimal-responders-to-ifn-beta-in-ms
#8
Raquel Alenda, Lucienne Costa-Frossard, Roberto Alvarez-Lafuente, Carmen Espejo, Eulalia Rodríguez-Martín, Susana Sainz de la Maza, Noelia Villarrubia, Jordi Río, María I Domínguez-Mozo, Xavier Montalban, José C Álvarez-Cermeño, Luisa M Villar
Response to interferon-beta (IFN-beta) treatment is heterogeneous in multiple sclerosis (MS). We aimed to search for biomarkers predicting no evidence of disease activity (NEDA) status upon IFN-beta treatment in MS. 119 patients with relapsing-remitting MS (RRMS) initiating IFN-beta treatment were included in the study, and followed prospectively for 2 years. Neutralizing antibodies (NAb) were explored in serum samples obtained after 6 and 12 months of IFN-beta treatment. Soluble cytokines and blood lymphocytes were studied in basal samples by ELISA and flow cytometry, respectively...
October 12, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29026745/psychometric-properties-of-the-trust-in-physician-scale-in-tamil-nadu-india
#9
Maria Jusler Kalsingh, Geetha Veliah, Vijayaprasad Gopichandran
CONTEXT: Trust in health care is of high intrinsic value. It also leads to positive outcomes such as better treatment adherence and disclosure of sensitive information. Therefore, there is a need to measure trust in health care objectively. AIMS: To assess the psychometric properties of the Trust in Physician Scale in Tamil Nadu, India. SETTINGS AND DESIGN: The study was conducted in a private tertiary hospital setting in Tamil Nadu by a cross-sectional survey design...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026111/distraction-and-expressive-suppression-strategies-in-regulation-of-high-and-low-intensity-negative-emotions
#10
Ping Li, Wei Wang, Cong Fan, Chuanlin Zhu, Shuaixia Li, Zhao Zhang, Zhengyang Qi, Wenbo Luo
The current study compared the effectiveness of distraction, an antecedent-focused strategy that involves diverting an individual's attention away from affective terms, and expressive suppression, a response-focused strategy that involves inhibiting conscious emotion-expressive behavior during an emotionally aroused state, in the regulation of high- and low-intensity unpleasant stimuli, using event-related potentials (ERPs). Sixteen participants completed an emotion regulation experiment in which they passively viewed high- or low-intensity unpleasant images (view), solved a mathematical equation presented on high- or low-intensity negative images (distraction), or suppressed their emotional expression in response to high- or low-intensity unpleasant images (suppression)...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29026056/patient-opinion-of-lower-urinary-tract-symptoms-and-their-treatment-a-cross-sectional-survey-in-hong-kong-public-urology-clinics
#11
L Y Ho, C K Chan, P Sk Chu
INTRODUCTION: Lower urinary tract symptoms collectively represent a common condition among ageing men. There are, however, limited data on the frequency of individual symptoms in patients who seek specialist care. We conducted a multinational survey in South-East Asia to evaluate patients' self-reported prevalence, bother, treatment, and treatment satisfaction of four lower urinary tract symptoms namely, urgency, nocturia, slow stream, and post-micturition dribble. This report presents the analysis of the Hong Kong subpopulation...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29025820/well-being-of-family-medicine-graduates
#12
Olga Szafran, Wayne Woloschuk, Jacqueline M I Torti, Douglas Myhre
OBJECTIVE: To determine family medicine graduates' professional and personal well-being, general health status, stress levels, coping strategies, and the degree to which they felt supported or isolated in professional life; and to compare findings by sex, practice location, and location of medical school (Canadian medical graduates [CMGs] vs international medical graduates [IMGs]). DESIGN: Retrospective, cross-sectional survey. SETTING: University of Alberta in Edmonton and the University of Calgary in Alberta...
October 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29025729/live-cell-imaging-of-cytosolic-nadh-nad-ratio-in-hepatocytes-and-liver-slices
#13
Ricard Masia, William J McCarty, Carolina Lahmann, Jay Luther, Raymond T Chung, Martin L Yarmush, Gary Yellen
Fatty liver disease (FLD), the most common chronic liver disease in the US, may be caused by alcohol or the metabolic syndrome. Alcohol is oxidized in the cytosol of hepatocytes by alcohol dehydrogenase (ADH), which generates NADH and increases cytosolic NADH/NAD(+) ratio. The increased ratio may be important for development of FLD, but our ability to examine this question is hindered by methodological limitations. To address this, we used the genetically-encoded fluorescent sensor Peredox to obtain dynamic, real-time measurements of cytosolic NADH/NAD(+) ratio in living hepatocytes...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29025373/the-prognostic-value-of-high-sensitive-cardiac-troponin-i-in-patients-receiving-cardiac-resynchronisation-therapy
#14
Michal Kerekanič, Marek Hudák, Silvia Mišíková, Erika Komanová, Alexander Bohó, Ján Kyselovič, Branislav Stančák
BACKGROUND: Cardiac troponin I (cTnI) is a valuable prognostic biomarker in patients with chronic heart failure (CHF). However, the prognostic importance of cTnI in patients who received cardiac resynchronisation therapy (CRT) remains unknown. The aim of this prospective study was to determine the prognostic value of high-sensitive cTnI (hs-cTnI) in CHF patients receiving CRT. METHODS: We performed measurements of baseline hs-cTnI levels in CRT patients with ischaemic as well as nonischaemic aetiology of CHF, and we investigated their possible association with response to CRT and survival of patients...
October 12, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29025136/predictors-of-responsivity-to-interdisciplinary-pain-management
#15
Melissa A Day, Melissa Brinums, Nathan Craig, Laurence Geffen, Saul Geffen, Miriam Lovai, Gina Geffen
Objective: This study investigated for whom interdisciplinary pain management (IPM) is most effective. Identification of predictors of treatment responsivity would facilitate development of patient-treatment matching algorithms to optimize outcomes. Design: Repeated measures prospective study of consecutive admissions to a two-week IPM program. Setting: Brisbane Pain Rehabilitation Service in Brisbane, Australia. Subjects: A total of 163 adults referred for chronic pain management...
July 25, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29025125/how-well-do-general-practitioners-manage-laboratory-test-results-for-patients-with-diabetes-mellitus-and-cardiovascular-disease-a-systematic-review
#16
Euan J McCaughey, Julie Li, Tony C Badrick, Johanna I Westbrook, Andrew Georgiou
Purpose: To evaluate how well general practitioners (GPs) manage and respond to laboratory results for patients with diabetes mellitus (DM) and cardiovascular disease (CVD). Data sources: MEDLINE, CINAHL, Embase, EBM reviews, ProQuest and Scopus. Study selection: Peer-reviewed journal articles published between 2000 and 2015 that assessed GPs' management of laboratory results for patients with DM or CVD. Data extraction: Study design and demographics, laboratory tests and key findings relating to GP management of laboratory results were extracted from studies...
August 28, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29025076/impact-of-smoking-alcohol-consumption-and-nsaid-use-on-risk-for-and-phenotypes-of-eosinophilic-esophagitis
#17
Nathaniel T Koutlas, Swathi Eluri, Spencer Rusin, Irina Perjar, Johnathan Hollyfield, John T Woosley, Nicholas J Shaheen, Evan S Dellon
There are few data exploring modifiable risk factors for eosinophilic esophagitis (EoE). We aimed to determine if smoking, alcohol consumption, and NSAID use were risk factors for EoE, and to assess their impact on EoE phenotypes and treatment outcomes. We performed a case-control study analyzing data collected from a prospective cohort of adults undergoing upper endoscopy for symptoms of esophageal dysfunction. Incident EoE cases were diagnosed via consensus guidelines. Exposure data were collected via standardized patient questionnaire...
August 30, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29025020/doctors-views-of-patient-expectations-of-medical-care-in-zhejiang-province-china
#18
Dan Wu, Tai Pong Lam, Kwok Fai Lam, Xu Dong Zhou, Kai Sing Sun
Objective: Physicians' prescribing patterns may be influenced by how they perceive their patients' expectations of medical care. This study explored doctors' perceptions of patient expectations of medical care. Design: Qualitative interviews and a cross-sectional survey (September 2014-September 2015). Setting: Primary- and tertiary-care facilities in Zhejiang province, China. Participants: Primary care practitioners (PCPs) and hospital specialists...
September 7, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29024973/re-employment-job-quality-health-and-allostatic-load-biomarkers-prospective-evidence-from-the-uk-household-longitudinal-study
#19
Tarani Chandola, Nan Zhang
Background: There is little evidence on whether becoming re-employed in poor quality work is better for health and well-being than remaining unemployed. We examined associations of job transition with health and chronic stress-related biomarkers among a population-representative cohort of unemployed British adults. Methods: A prospective cohort of 1116 eligible participants aged 35 to 75 years, who were unemployed at wave 1 (2009/10) of the UK Household Longitudinal Study, were followed up at waves 2 (2010/11) and 3 (2011/12) for allostatic load biomarkers and self-reported health...
August 10, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024871/brain-energetics-during-the-sleep-wake-cycle
#20
REVIEW
Mauro DiNuzzo, Maiken Nedergaard
Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid...
October 9, 2017: Current Opinion in Neurobiology
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