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https://www.readbyqxmd.com/read/28231575/individual-biomarkers-using-molecular-personalized-medicine-approaches
#1
Hans P Zenner
Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern "omex" technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28231425/practice-patterns-regarding-multidisciplinary-cancer-management-and-suggestions-for-further-refinement-results-from-a-national-survey-in-korea
#2
Yun-Gyoo Lee, Sukjoong Oh, Heejin Kimm, Dong-Hoe Koo, Do Yeun Kim, Bong-Seog Kim, Seung-Sei Lee
Purpose: This study was conducted to explore the process and operation of a cancer multidisciplinary team (MDT) after the reimbursement decision in Korea, and to identify ways to overcome the major barriers to effective and sustainable MDTs. Materials and Methods: Approximately 1000 cancer specialists, including medical oncologists, surgical oncologists, radiation oncologists, pathologists, and radiologists in general hospitals in Korea were invited to complete the survey...
February 22, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28231311/handwashing-and-ebola-virus-disease-outbreaks-a-randomized-comparison-of-soap-hand-sanitizer-and-0-05-chlorine-solutions-on-the-inactivation-and-removal-of-model-organisms-phi6-and-e-coli-from-hands-and-persistence-in-rinse-water
#3
Marlene K Wolfe, Karin Gallandat, Kyle Daniels, Anne Marie Desmarais, Pamela Scheinman, Daniele Lantagne
To prevent Ebola transmission, frequent handwashing is recommended in Ebola Treatment Units and communities. However, little is known about which handwashing protocol is most efficacious. We evaluated six handwashing protocols (soap and water, alcohol-based hand sanitizer (ABHS), and 0.05% sodium dichloroisocyanurate, high-test hypochlorite, and stabilized and non-stabilized sodium hypochlorite solutions) for 1) efficacy of handwashing on the removal and inactivation of non-pathogenic model organisms and, 2) persistence of organisms in rinse water...
2017: PloS One
https://www.readbyqxmd.com/read/28231148/potential-use-of-gamma-irradiated-ethnic-ready-to-eat-foods-to-improve-the-nutritional-status-of-landslide-victims
#4
REVIEW
Zubaidah Irawati Koenari, Carmen M Siagian, Bona Simanungkalit, Asti Nilatany, Indra Mustika Pratama, Deudeu Lasmawati, Cecep M Nurcahya
The safety and high quality of ethnic ready-to-eat foods as a source of nourishment and food supplies chain to the remote areas become particularly important. Consuming healthy and balanced nutritional foods means eating better quality foods in proper quantities. Such foods can be developed through a preservation technique by using ionizing radiation. Although implementation of the technology for certain foodstuffs has been implemented in some countries, application of the process to a complete set of meals for selected target groups is still very limited...
July 26, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230651/hypoxia-induces-internalization-of-%C3%AE%C2%BA-opioid-receptor
#5
Chunhua Xi, Xuan Liang, Chunhua Chen, Hasan Babazada, Tianzuo Li, Renyu Liu
BACKGROUND: It has been demonstrated that κ-opioid receptor agonists can reduce hypoxia-ischemia brain injury in animal models. However, it is unclear how the κ-opioid receptor responds to hypoxia-ischemia. In the current study, the authors used an in vitro model of oxygen-glucose deprivation and reoxygenation to explore how κ-opioid receptors respond to hypoxia and reoxygenation. METHODS: Mouse neuroblastoma Neuro2A cells were stably transfected with mouse κ-opioid receptor-tdTomato fusion protein or Flag-tagged mouse κ-opioid receptor, divided into several groups (n = 6 to 12), and used to investigate the κ-opioid receptor movement...
February 23, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28229936/neurons-of-the-rat-cervical-spinal-cord-express-vimentin-and-neurofilament-after-intraparenchymal-injection-of-kainic-acid
#6
Fabián Nishida, Susana M Sisti, Carolina N Zanuzzi, Claudio G Barbeito, Enrique L Portiansky
Intermediate filaments (IF) can be altered under disorders such as neurodegenerative diseases. Kainic acid (KA) induce behavioral changes and histopathological alterations of the spinal cord of injected rats. Our goal was to evaluate the IF expression in neurons during this injury model. Animals were injected with KA at the C5 segment of the cervical spinal cord and euthanized at 1, 3 and 7 post injection (pi) days. Neuronal cell counting showed a significant loss of neurons at the injection site when compared with those of sham and non-operated animals...
February 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28229527/melanotransferrin-new-homolog-genes-and-their-differential-expression-during-intestinal-regeneration-in-the-sea-cucumber-holothuria-glaberrima
#7
Josué Hernández-Pasos, Griselle Valentín-Tirado, José E García-Arrarás
Melanotransferrin (MTf) is a protein associated with oncogenetic, developmental, and immune processes which function remains unclear. The MTf gene has been reported in numerous vertebrate and invertebrate species, including echinoderms. We now report the finding of four different MTfs in the transcriptome of the sea cucumber Holothuria glaberrima. Sequence studies and phylogenetic analyses were done to ascertain the similarities among the putative proteins and their relationship with other transferrin family members...
February 23, 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/28229497/drinkers-identification-with-varying-alcohol-consumption-prototypes
#8
Simone Pettigrew, Michelle I Jongenelis, Iain S Pratt, Terry Slevin, Tanya Chikritzhs
INTRODUCTION AND AIMS: Efforts to reduce excessive alcohol consumption need to take into account drinkers' perceptions of their risk of alcohol-related harm. The aim of the present study was to profile adult Australian drinkers according to their self-identification with various drinker prototypes to determine the extent to which these prototypes are associated with perceived and actual risk of alcohol-related harm. DESIGN AND METHODS: A large web panel provider disseminated an online survey to a national sample of 2168 drinkers aged 18+ years who consumed alcohol at least twice per month...
February 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28229473/nurses-response-to-parents-speaking-up-efforts-to-ensure-their-hospitalized-child-s-safety-an-attribution-theory-perspective
#9
Sondos Basharat, Anat Drach-Zahavy
AIM: To understand how attribution processes (control and stability), which the nurse attributes to parental involvement in maintaining child safety, determine the nurse's response to a safety alert. BACKGROUND: Participation of parents in maintaining their child's safety is shown to reduce the incidence of and risk of clinical errors. Unless nurses respond appropriately to parents' safety alerts, this potential source of support could diminish. DESIGN: A 2 (controllability: high vs...
February 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28229464/modified-atkins-diet-is-an-effective-treatment-for-children-with-doose-syndrome
#10
Adelheid Wiemer-Kruel, Edda Haberlandt, Hans Hartmann, Gabriele Wohlrab, Thomas Bast
OBJECTIVE: Children with myoclonic astatic epilepsy (MAE; Doose syndrome) whose seizures do not respond immediately to standard antiepileptic drugs (AEDs) are at high risk of developing an epileptic encephalopathy with cognitive decline. A classic ketogenic diet (KD) is a highly effective alternative to AEDs. To date, there are only limited data on the effectiveness of the modified Atkins diet (MAD), which is less restrictive and more compatible with daily life. We report findings from a retrospective study on 30 MAE patients treated with MAD...
February 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28229347/the-role-of-questioning-environment-personality-traits-depressive-and-anxiety-symptoms-in-tinnitus-severity-perception
#11
Robertas Strumila, Aistė Lengvenytė, Vija Vainutienė, Eugenijus Lesinskas
Psychological factors have been described as important for tinnitus severity, but attempts to incorporate them in one picture are sparse. This study investigated to what extent traits (personality), states (depressive and anxiety symptoms), sociodemographic factors and questioning environment influence tinnitus severity perception and how they interplay. Data were obtained from 212 subjects in a survey that was undertaken in 2016 at Vilnius University hospital and via internet. Measures included the Tinnitus Handicap Inventory (THI), Visual Analogue Scale (VAS), Hospital Anxiety and Depression Scale (HADS), Big Five Personality Dimensions Scale and sociodemographic questions...
February 23, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28229178/the-consummatory-and-motivational-behaviors-for-natural-rewards-following-long-term-withdrawal-from-morphine-no-anhedonia-but-persistent-maladaptive-behaviors-for-high-value-rewards
#12
Yingying Li, Xigeng Zheng, Na Xu, Yue Zhang, Zhengkui Liu, Yunjing Bai
RATIONALE: The negative affective state, e.g., anhedonia, emerges after abstinence from abused drugs may be linked to the motivational processes of drug craving and relapse. Although anhedonia diminishes over time with drug abstinence, it is not yet rather explicit whether anhedonia exists or not following protracted withdrawal. OBJECTIVES: The behavioral responses to natural rewards were examined after 2 to 3 weeks withdrawal from morphine. Male rats were pretreated with either a binge-like morphine paradigm or daily saline injection for 5 days...
February 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28228301/shoshin-beriberi-thiamine-responsive-pulmonary-hypertension-in-exclusively-breastfed-infants-a-study-from-northern-india
#13
Javeed Iqbal Bhat, Hilal Ahmad Rather, Ambreen Ali Ahangar, Umar Amin Qureshi, Parvez Dar, Qazi Iqbal Ahmed, Bashir Ahmed Charoo, Syed Wajid Ali
OBJECTIVE: To study the effect of thiamine administration on the resolution of pulmonary hypertension in exclusively breastfed infants. DESIGN: Prospective cohort study. SETTING: Hospital based study of a tertiary care hospital. PATIENTS: A total of 29 infants with 17 males (58.6%) and 12 females (41.4%) were included in the study. INTERVENTION: In addition to the management of shock, right heart failure and renal failure, patients received intravenous thiamine 100mg/kg IV followed by 10mg/day till introduction of supplementary feeds...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228110/a-nationwide-survey-of-first-aid-training-and-encounters-in-norway
#14
Håkon Kvåle Bakke, Tine Steinvik, Johan Angell, Torben Wisborg
BACKGROUND: Bystander first aid can improve survival following out-of-hospital cardiac arrest or trauma. Thus, providing first aid education to laypersons may lead to better outcomes. In this study, we aimed to establish the prevalence and distribution of first aid training in the populace, how often first aid skills are needed, and self-reported helping behaviour. METHODS: We conducted a telephone survey of 1000 respondents who were representative of the Norwegian population...
February 23, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#15
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226822/hidden-markov-factor-analysis-as-a-spatiotemporal-model-for-electrocorticography
#16
Akinyinka Omigbodun, Werner K Doyle, Orrin Devinsky, Daniel Friedman, Thomas Thesen, Vikash Gilja, Akinyinka Omigbodun, Werner K Doyle, Orrin Devinsky, Daniel Friedman, Thomas Thesen, Vikash Gilja, Akinyinka Omigbodun, Thomas Thesen, Vikash Gilja, Werner K Doyle, Orrin Devinsky, Daniel Friedman
We present a new approach to extracting low-dimensional neural trajectories that summarize the electrocorticographic (ECoG) signals recorded with high-channel-count electrode arrays implanted subdurally. In our approach, Hidden-Markov Factor Analysis (HMFA), a finite set of factor analyzers are used to model the relationship between the high-dimensional ECoG neural space and a low-dimensional latent neural space; the factor analyzers at different time points are in turn linked together with a hidden Markov model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226436/optimizing-rtms-treatment-of-a-balance-disorder-with-eeg-neural-synchrony-and-functional-connectivity
#17
Guofa Shou, Han Yuan, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Guofa Shou, Han Yuan, Diamond Urbano, Yoon-Hee Cha, Lei Ding, Han Yuan, Yoon-Hee Cha, Diamond Urbano, Lei Ding, Guofa Shou
Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used for its potential treatment effects across diverse mental disorders. However, the treatment effect is elusive and the rate of positive responders is not high, which make it in great demand of optimizing rTMS protocols to improve the treatment effects and the rate. In this regard, neural activity guided optimization has indicated great potential in several neuroimaging studies. In this paper, we present our ongoing work on optimizing rTMS treatment of a balance disorder, i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226414/methylene-blue-for-the-treatment-of-intractable-pain-associated-with-oral-mucositis
#18
Carlos J Roldan, Kent Nouri, Thomas Chai, Billy Huh
Oral mucositis is a common and often debilitating complication among cancer patients receiving radiation therapy to the head and neck or chemotherapy agents, or undergoing hematopoietic stem cell transplantation. Pain and decreased oral function associated with oral mucositis may persist long after the conclusion of therapy. Although most patients respond to conservative management, a subset of patients develop intractable pain with severe consequences. For some, the use of total parenteral nutrition with insertion of percutaneous endoscopic gastrostomy feeding tubes is the only alternative...
February 22, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28226305/effect-of-maternal-rumination-and-disengagement-during-childhood-on-offspring-neural-response-to-reward-in-late-adolescence
#19
Judith K Morgan, Daniel S Shaw, Rachel H Jacobs, Sarah E Romens, Stephanie L Sitnick, Erika E Forbes
Maternal rumination is a cognitive-affective trait that could influence offspring's ability to respond flexibly to positive and negative events, depending on the quality of maternal problem-solving behaviors with which rumination co-occurs. As reward circuitry is sensitive to stressors and related to risk for depression, reward circuitry is an appropriate candidate mechanism for how maternal characteristics influence offspring. We evaluated the independent and combined effect of maternal rumination and disengagement on adolescent neural response to reward win and loss...
February 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28226258/a-new-hypervolume-approach-for-assessing-environmental-risks
#20
Denys Yemshanov, Frank H Koch, Bo Lu, Ronald Fournier, Gericke Cook, Jean J Turgeon
Assessing risks of uncertain but potentially damaging events, such as environmental disturbances, disease outbreaks and pest invasions, is a key analytical step that informs subsequent decisions about how to respond to these events. We present a continuous risk measure that can be used to assess and prioritize environmental risks from uncertain data in a geographical domain. The metric is influenced by both the expected magnitude of risk and its uncertainty. We demonstrate the approach by assessing risks of human-mediated spread of Asian longhorned beetle (ALB, Anoplophora glabripennis) in Greater Toronto (Ontario, Canada)...
February 19, 2017: Journal of Environmental Management
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