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https://www.readbyqxmd.com/read/28719780/venous-thromboembolic-prophylaxis-in-foot-and-ankle-surgery-a-review-of-current-literature-and-practice
#1
Martin H S Weisman, James R Holmes, Todd A Irwin, Paul G Talusan
Venous thromboembolism (VTE) is a well-known and feared complication following foot and ankle surgery, as it is a source of morbidity and mortality in the perioperative phase. The most recent CHEST guidelines recommended against the use of chemoprophylaxis and the majority of the literature has found a low incidence of VTE following foot and ankle surgery. Some authors prefer screening patients for risk factors and recommend the use of chemoprophylaxis on a case-by-case basis. Interestingly, studies that found high incidence of VTE were unable to determine a statistically significant difference between the prophylaxis and placebo groups...
August 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28719628/salt-tolerant-and-sensitive-alfalfa-medicago-sativa-cultivars-have-large-variations-in-defense-responses-to-the-lepidopteran-insect-spodoptera-litura-under-normal-and-salt-stress-condition
#2
Yunting Lei, Qing Liu, Christian Hettenhausen, Guoyan Cao, Qing Tan, Weiye Zhao, Honghui Lin, Jianqiang Wu
In nature, plants are often exposed to multiple stress factors at the same time. Yet, little is known about how plants modulate their physiology to counteract simultaneous abiotic and biotic stresses, such as soil salinity and insect herbivory. In this study, insect performance bioassays, phytohormone measurements, quantification of transcripts, and protein determination were employed to study the phenotypic variations of two alfalfa (Medicago sativa) cultivars in response to insect Spodoptera litura feeding under normal and salt stress condition...
2017: PloS One
https://www.readbyqxmd.com/read/28719256/therapeutic-dilemma-of-refractory-erythema-nodosum-leprosum
#3
Jianyu Zhu, Degang Yang, Chao Shi, Zhichun Jing
AbstractErythema nodosum leprosum (ENL), also known as type II leprosy reaction, is a severe immune-mediated complication of multibacillary leprosy. For ENL, corticosteroids and thalidomide are the mainstays of treatment. Other immunosuppressants, such as clofazimine, cyclosporine, and azathioprine have also been used. Although most patients with ENL respond well to conventional treatments, a small number are refractory to these therapies and have severe morbidity or mortality. We report the case of a 24-year-old man with refractory ENL treated with high-dose corticosteroids for 15 months...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718878/deep-brain-and-cortical-stimulation-for-epilepsy
#4
REVIEW
Mathieu Sprengers, Kristl Vonck, Evelien Carrette, Anthony G Marson, Paul Boon
BACKGROUND: Despite optimal medical treatment, including epilepsy surgery, many epilepsy patients have uncontrolled seizures. Since the 1970s interest has grown in invasive intracranial neurostimulation as a treatment for these patients. Intracranial stimulation includes both deep brain stimulation (DBS) (stimulation through depth electrodes) and cortical stimulation (subdural electrodes). This is an updated version of a previous Cochrane review published in 2014. OBJECTIVES: To assess the efficacy, safety and tolerability of DBS and cortical stimulation for refractory epilepsy based on randomized controlled trials (RCTs)...
July 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28718831/management-effectiveness-of-a-secondary-coniferous-forest-for-landscape-appreciation-and-psychological-restoration
#5
Norimasa Takayama, Akio Fujiwara, Haruo Saito, Masahiro Horiuchi
We investigated the influence of forest management on landscape appreciation and psychological restoration in on-site settings by exposing respondents to an unmanaged, dense coniferous (crowding) forest and a managed (thinned) coniferous forest; we set the two experimental settings in the forests of the Fuji Iyashinomoroi Woodland Study Center. The respondents were individually exposed to both settings while sitting for 15 min and were required to answer three questionnaires to analyze the psychological restorative effects before and after the experiment (feeling (the Profile of Mood States), affect (the Positive and Negative Affect Schedule), and subjective restorativeness (the Restorative Outcome Scale)...
July 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28718252/use-of-complementary-and-alternative-medicine-among-asthmatic-patients
#6
Fawad Ahmed, Ayaz Ayub, Hamid Hussain
BACKGROUND: The prevalence of complementary and alternative medicine (CAM) use in some developed countries is on the rise as surveys conducted on large scale vouch for. This study was conducted with the aim to determine the frequency of complementary and alternative medicine (CAM) use among asthmatic patients at outpatient department of tertiary care hospitals in Peshawar, Khyber Pakhtunkhwa, Pakistan. METHODS: This cross-sectional study was conducted in outpatient department of two tertiary care hospitals...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28718188/weaning-premature-infants-from-nasal-continuous-positive-airway-pressure-current-practice-and-scientific-evidence
#7
André Kidszun, Christine Arnold, Julia Winter, Catharina Whybra-Trümpler, Eva Mildenberger
Objective In the past decade, a number of trials have been conducted to determine the optimal strategy of weaning premature infants from nasal continuous airway pressure (nCPAP). However, a paucity of information exists on how weaning is actually performed in clinical routine. Aim of this study was to investigate the current practice of weaning premature infants from nCPAP in Germany. Methods An online survey was performed in German tertiary care neonatal units. Results All 160 German tertiary care units were contacted...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28717877/temporal-envelope-coding-by-inferior-colliculus-neurons-with-cochlear-implant-stimulation
#8
Kenneth E Hancock, Yoojin Chung, Martin F McKinney, Bertrand Delgutte
Modulations in temporal envelopes are a ubiquitous property of natural sounds and are especially important for hearing with cochlear implants (CIs) because these devices typically discard temporal fine structure information. With few exceptions, neural temporal envelope processing has been studied in both normal hearing (NH) and CI animals using only pure sinusoidal amplitude modulation (SAM) which poorly represents the diversity of envelope shapes contained in natural sounds because it confounds repetition rate and the width of each modulation cycle...
July 17, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28717805/relationship-between-diet-related-indicators-and-overweight-and-obesity-in-older-adults-in-rural-japan
#9
M Ishikawa, S Moriya, T Yokoyama
OBJECTIVES: To identify the relationship between diet-related indicators and overweight and obesity in older adults in rural Japan. DESIGN: Cross-sectional survey. SETTING: Obira, Hokkaido, Japan. PARTICIPANTS: Local residents aged between 65 and 74 years, except for those with poor health, were included. INTERVENTION: A health- and diet-related questionnaire was applied to participants house-to-house by trained health professionals...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28717786/setting-priorities-for-diabetic-retinopathy-clinical-research-and-identifying-evidence-gaps
#10
Jimmy T Le, Susan Hutfless, Tianjing Li, Neil M Bressler, James Heyward, Ava K Bittner, Adam Glassman, Kay Dickersin
PURPOSE: Prioritizing comparative effectiveness research may contribute to obtaining answers that clinicians perceive they need and may minimize research that could be considered wasteful. Our objective was to identify evidence gaps and set priorities for new systematic reviews and randomized controlled trials for managing diabetic retinopathy (DR), including diabetic macular edema (DME). DESIGN: Cross-sectional study. PARTICIPANTS: Diabetic Retinopathy Clinical Research Network (DRCR...
March 2017: Ophthalmology retina
https://www.readbyqxmd.com/read/28717698/neuroblastoma-in-africa-a-survey-by-the-franco-african-pediatric-oncology-group
#11
Fousseyni Traoré, Francis Eshun, Boubacar Togo, Jean Jacques Atteby Yao, Mbuli Robert Lukamba
PURPOSE: Neuroblastoma is a sympathoadrenal lineage neural crest-derived tumor. It is the third most common childhood malignancy in the Western world. Studies from the United States show that black patients with neuroblastoma have a greater proportion of high-risk neuroblastoma with poorer prognosis compared with white patients. In Africa, there are few published data on the epidemiology and management of neuroblastoma. The primary aim of this study was to assess the diagnostic and therapeutic resources available for the management of neuroblastoma within the Franco-African Pediatric Oncology Group (GFAOP)...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717658/targeting-breast-cancer-outcomes-what-about-the-primary-relatives
#12
Alison Johnston, Michael Sugrue
BACKGROUND: Up to 65% of newly diagnosed breast cancer patients had not been screened correctly before diagnosis resulting in increased stage of cancer at presentation. This study assessed whether their primary relatives are, in turn, assessed appropriately. METHODS: An ethically approved prospective study involving 274 primary relatives of women diagnosed with breast cancer, between 2009-2012, at a symptomatic breast unit in Ireland. Telephone interview established: demographics, menstrual history, family history verification, breast screening history...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28716720/met-signaling-mediates-intestinal-crypt-villus-development-regeneration-and-adenoma-formation-and-is-promoted-by-stem-cell-cd44-isoforms
#13
Sander P J Joosten, Jurrit Zeilstra, Harmen van Andel, R Clinton Mijnals, Joost Zaunbrecher, Annet A M Duivenvoorden, Marc van de Wetering, Hans Clevers, Marcel Spaargaren, Steven T Pals
BACKGROUND & AIMS: Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor receptor (EGFR) signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the receptor for hepatocyte growth factor (HGF). We investigated how MET signaling, and its interaction with CD44 (a putative MET co-receptor regulated by Wnt signaling and highly expressed by intestinal stem cells [ISCs] and adenomas) affects intestinal homeostasis, regeneration, and adenoma formation in mini-gut organoids and mice...
July 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28716555/attitudes-about-vaccines-to-prevent-ebola-virus-disease-in-guinea-at-the-end-of-a-large-ebola-epidemic-results-of-a-national-household-survey
#14
Kathleen L Irwin, Mohamed F Jalloh, Jamaica Corker, Barry Alpha Mahmoud, Susan J Robinson, Wenshu Li, Nyuma E James, Musa Sellu, Mohammad B Jalloh, Alpha Ahmadou Diallo, LaRee Tracy, Rana Hajjeh, Amanda VanSteelandt, Rebecca Bunnell, Lise Martel, Pratima L Raghunathan, Barbara Marston
INTRODUCTION: In 2014-2016, an Ebola epidemic devastated Guinea; more than 3800 cases and 2500 deaths were reported to the World Health Organization. In August 2015, as the epidemic waned and clinical trials of an experimental, Ebola vaccine continued in Guinea and neighboring Sierra Leone, we conducted a national household survey about Ebola-related knowledge, attitudes, and practices (KAP) and opinions about "hypothetical" Ebola vaccines. METHODS: Using cluster-randomized sampling, we selected participants aged 15+ years old in Guinea's 8 administrative regions, which had varied cumulative case counts...
July 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28716105/characterization-of-four-rice-uev1-genes-required-for-lys63-linked-polyubiquitination-and-distinct-functions
#15
Qian Wang, Yuepeng Zang, Xuan Zhou, Wei Xiao
BACKGROUND: The error-free branch of the DNA-damage tolerance (DDT) pathway is orchestrated by Lys63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA), and this polyubiquitination is mediated by a Ubc13-Uev complex in yeast. We have previously cloned OsUBC13 from rice, whose product functions as an E2 to promote Lys63-linked ubiquitin chain assembly in the presence of yeast or human Uev. RESULTS: Here we identify four highly conserved UEV1 genes in rice whose products are able to form stable heterodimers with OsUbc13 and mediate Lys63-linked ubiquitin chain assembly...
July 17, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28716093/c-elegans-sup-46-an-hnrnpm-family-rna-binding-protein-that-prevents-paternally-mediated-epigenetic-sterility
#16
Wendy L Johnston, Aldis Krizus, Arun K Ramani, Wade Dunham, Ji Young Youn, Andrew G Fraser, Anne-Claude Gingras, James W Dennis
BACKGROUND: In addition to DNA, gametes contribute epigenetic information in the form of histones and non-coding RNA. Epigenetic programs often respond to stressful environmental conditions and provide a heritable history of ancestral stress that allows for adaptation and propagation of the species. In the nematode C. elegans, defective epigenetic transmission often manifests as progressive germline mortality. We previously isolated sup-46 in a screen for suppressors of the hexosamine pathway gene mutant, gna-2(qa705)...
July 17, 2017: BMC Biology
https://www.readbyqxmd.com/read/28716048/transcriptome-analysis-uncovers-arabidopsis-f-box-stress-induced-1-as-a-regulator-of-jasmonic-acid-and-abscisic-acid-stress-gene-expression
#17
Lauren E Gonzalez, Kristen Keller, Karen X Chan, Megan M Gessel, Bryan C Thines
BACKGROUND: The ubiquitin 26S proteasome system (UPS) selectively degrades cellular proteins, which results in physiological changes to eukaryotic cells. F-box proteins are substrate adaptors within the UPS and are responsible for the diversity of potential protein targets. Plant genomes are enriched in F-box genes, but the vast majority of these have unknown roles. This work investigated the Arabidopsis F-box gene F-BOX STRESS INDUCED 1 (FBS1) for its effects on gene expression in order elucidate its previously unknown biological function...
July 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28715314/optimizing-electric-field-delivery-for-tdcs-virtual-humans-help-to-design-efficient-noninvasive-brain-and-spinal-cord-electrical-stimulation
#18
Pedro C Miranda, Ricardo Salvador, Cornelia Wenger, Sofia R Fernandes
Noninvasive electrical stimulation of the central nervous system is attracting increasing interest from the clinical and academic communities as well as from high-tech companies. This interest was sparked by two landmark studies conducted in 2000 and 2001 at the University of G?ttingen, Germany. Michael Nitsche and Walter Paulus showed that by passing a weak, almost imperceptible electric current between two electrodes on the scalp, they could alter the way the human brain responds to stimuli and that the effect persisted for some time after the current was stopped...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28715249/durable-molecular-remissions-in-chronic-lymphocytic-leukemia-treated-with-cd19-specific-chimeric-antigen-receptor-modified-t-cells-after-failure-of-ibrutinib
#19
Cameron J Turtle, Kevin A Hay, Laïla-Aïcha Hanafi, Daniel Li, Sindhu Cherian, Xueyan Chen, Brent Wood, Arletta Lozanski, John C Byrd, Shelly Heimfeld, Stanley R Riddell, David G Maloney
Purpose We evaluated the safety and feasibility of anti-CD19 chimeric antigen receptor-modified T (CAR-T) cell therapy in patients with chronic lymphocytic leukemia (CLL) who had previously received ibrutinib. Methods Twenty-four patients with CLL received lymphodepleting chemotherapy and anti-CD19 CAR-T cells at one of three dose levels (2 × 10(5), 2 × 10(6), or 2 × 10(7) CAR-T cells/kg). Nineteen patients experienced disease progression while receiving ibrutinib, three were ibrutinib intolerant, and two did not experience progression while receiving ibrutinib...
July 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28714919/overcoming-oncogenic-mediated-tumor-immunity-in-prostate-cancer
#20
REVIEW
Geoffrey Bryant, Lin Wang, David J Mulholland
Immunotherapy is being tested intensively in clinical trials for prostate cancer; it includes immune checkpoint inhibition, prostate specific antigen (PSA) vaccines and dendritic cell-based strategies. Despite increasing evidence for clinical responses, the consensus of multiple trials is that prostate cancers are poorly responsive to immunotherapy. Prostate cancer has a high degree of pathological and genetic heterogeneity compared to other cancer types, which may account for immunotherapeutic resistance. This hypothesis also implies that select types of prostate tumors may be differentially responsive to immune-based strategies and that the clinical stage, pathological grade and underlying genetic landscape may be important criteria in identifying tumors that respond to immune therapies...
July 17, 2017: International Journal of Molecular Sciences
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