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https://www.readbyqxmd.com/read/28531240/public-knowledge-and-understanding-of-dementia-evidence-from-a-national-survey-in-ireland
#1
Ronan W Glynn, Emer Shelley, Brian A Lawlor
Background: there is growing consensus around the importance of population level approaches which seek to improve public knowledge and awareness of dementia. Aim: to assess knowledge of the relationship between dementia and ageing, and of the risk and protective factors associated with it, among the general public in Ireland. Design: cross-sectional survey. Participants selected using quota sampling based on Census data. Methods: the final sample of 1,217 respondents provided estimates of dementia knowledge in the Irish population...
May 22, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28530038/hiv-treatment-and-care-services-for-adolescents-a-situational-analysis-of-218-facilities-in-23-sub-saharan-african-countries
#2
Daniella Mark, Alice Armstrong, Catarina Andrade, Martina Penazzato, Luann Hatane, Lina Taing, Toby Runciman, Jane Ferguson
INTRODUCTION: In 2013, an estimated 2.1 million adolescents (age 10-19 years) were living with HIV globally. The extent to which health facilities provide appropriate treatment and care was unknown. To support understanding of service availability in 2014, Paediatric-Adolescent Treatment Africa (PATA), a non-governmental organisation (NGO) supporting a network of health facilities across sub-Saharan Africa, undertook a facility-level situational analysis of adolescent HIV treatment and care services in 23 countries...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28529911/severe-trauma-in-the-geriatric-population
#3
REVIEW
Juan Antonio Llompart-Pou, Jon Pérez-Bárcena, Mario Chico-Fernández, Marcelino Sánchez-Casado, Joan Maria Raurich
Geriatric trauma constitutes an increasingly recognized problem. Aging results in a progressive decline in cellular function which leads to a loose of their capacity to respond to injury. Some medications commonly used in this population can mask or blunt the response to injury. Falls constitute the most common cause of trauma and the leading cause of trauma-related deaths in this population. Falls are complicated by the widespread use of antiplatelets and anticoagulants, especially in patients with brain injury...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28529418/intra-individual-right-left-comparative-study-of-medium-depth-peels-in-superficial-nail-abnormalities
#4
Deepashree Daulatabad, Soni Nanda, Chander Grover
BACKGROUND: Superficial nail abnormalities include conditions which produce nail surface changes such as trachyonychia, pitting and ridging. Mostly, this is a neglected area due to the dearth of treatment options. Glycolic acid peeling has been reported to be effective in such cases. AIM: This study aims to assess the safety and efficacy of medium depth peels (70% glycolic acid versus phenol combination peel [8% phenol with 15% trichloroacetic acid]) in patients with superficial nail abnormalities...
January 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28529220/clinical-correlates-of-treatment-response-among-patients-with-schizophrenia-in-a-tertiary-nigerian-hospital
#5
Mark Sunday Ezeme, Richard Uwakwe, Appolos Chidi Ndukuba, Monday N Igwe, Paul Chigozie Odinka, Kennedy Amadi, Nichodemus O Obayi
A significant proportion of patients treated for schizophrenia respond poorly to medication. Few studies have systematically examined the impact of clinical characteristics of patients to antipsychotic response in our environment. The study aimed to identify clinical variables associated with response in patients with schizophrenia. A total of 172 participants diagnosed with schizophrenia, placed on antipsychotics, who presented for the first time to the hospital or have stopped medication in the preceding six months, whose responses were assessed after four to six weeks were studied...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28528181/overexpression-of-long-noncoding-rna-h19-indicates-a-poor-prognosis-for-cholangiocarcinoma-and-promotes-cell-migration-and-invasion-by-affecting-epithelial-mesenchymal-transition
#6
Yi Xu, Zhidong Wang, Xingming Jiang, Yunfu Cui
Cholangiocarcinoma (CCA) is a deadly disease that poorly responds to chemotherapy and radiotherapy and whose incidence has increased worldwide. Furthermore, long noncoding RNAs (lncRNAs) play important roles in multiple biological processes, including tumorigenesis. Specifically, H19, the first discovered lncRNA, has been reported to be overexpressed in diverse human carcinomas, but the overall biological role and clinical significance of H19 in CCA remains unknown. In the present study, expression levels of H19 were investigated in CCA tissues and cell lines and were correlated with clinicopathological features...
May 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28527703/sperm-oocyte-contact-induces-outside-in-signaling-via-pyk2-activation
#7
Huizhen Wang, Jinping Luo, Carol Carlton, Lynda K McGinnis, William H Kinsey
Fertilization is a multi-step process that begins with plasma membrane interactions that enable sperm - oocyte binding followed by fusion of the sperm and oocyte plasma membranes. Once membrane fusion has occurred, sperm incorporation involves actin remodeling events within the oocyte cortex that allow the sperm head to penetrate the cortical actin layer and gain access to the ooplasm. Despite the significance for reproduction, the control mechanisms involved in gamete binding, fusion, and sperm incorporation are poorly understood...
May 17, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28527528/awareness-knowledge-and-interest-in-interventional-radiology-among-final-year-medical-students-in-england
#8
P A Atiiga, M Drozd, R Veettil
AIM: To investigate awareness, knowledge, and interests in interventional radiology (IR) among final year students. MATERIALS AND METHODS: Three hundred and fifty-nine anonymous questionnaires were distributed to final year medical students at two medical institutions in England. A total of 220 students (61%) responded. RESULTS: In the present study, 167 students (75.9%) correctly identified that interventional radiologists perform angioplasty and stenting of arteries...
May 17, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28526577/changes-in-tumor-cell-heterogeneity-after-chemotherapy-treatment-in-a-xenograft-model-of-glioblastoma
#9
Alessandra M Welker, Brian D Jaros, Min An, Christine E Beattie
Glioblastoma (GBM) is a highly aggressive brain cancer with limited treatments and poor patient survival. GBM tumors are heterogeneous containing a complex mixture of dividing cells, differentiated cells, and cancer stem cells. It is unclear, however, how these different cell populations contribute to tumor growth or whether they exhibit differential responses to chemotherapy. Here we set out to address these questions using a zebrafish xenograft transplant model (Welker et al., 2016). We found that a small population of differentiated vimentin positive tumor cells, but a majority of Sox2 positive putative cancer stem cells, were dividing during tumor growth...
May 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28525560/activity-dependent-gene-expression-in-the-mammalian-olfactory-epithelium
#10
Qiang Wang, William B Titlow, Declan A McClintock, Arnold J Stromberg, Timothy S McClintock
Activity-dependent processes are important to olfactory sensory neurons (OSNs) in several ways, such as cell survival and the specificity of axonal convergence. The identification of activity-dependent mRNAs has contributed to our understanding of OSN axon convergence, but has revealed surprisingly little about other processes. Published studies of activity-dependent mRNAs in olfactory mucosae overlap poorly, but by combining these agreements with meta-analysis of existing data we identify 443 mRNAs that respond to methods that alter OSN activity...
May 19, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28524242/women-with-vulvodynia-awareness-and-knowledge-of-its-care-among-student-healthcare-staff
#11
Minna Törnävä, Meeri Koivula, Mika Helminen, Tarja Suominen
BACKGROUND: Many women with vulvodynia are women of fertile age, and this syndrome may cause many physical and psychosexual functional disorders. Women with vulvodynia often find that healthcare professionals seem to demonstrate a lack of awareness about the syndrome and its care. These issues have not been previously studied among student healthcare staff. AIM: To investigate awareness and knowledge about vulvodynia and its care among staff in the student healthcare sector in Finland...
May 19, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28522791/career-in-vascular-surgery-the-medical-student-s-perspective
#12
Malwina K Grobelna, Hubert Stępak, Barbara Kołodziejczak, Łukasz Dzieciuchowicz, Grzegorz Oszkinis
AIM: Under the supervision of the Department of General and Vascular Surgery of Poznan University of Medical Sciences, a questionnaire was distributed online or as a paper version to medical students (MSs) in order to better understand the attitudes towards surgery as a specialty and to determine the reasons why students do and do not choose vascular surgery as their career path. MATERIALS AND METHODS: The questionnaire was distributed online or as a paper version to MSs in the 3rd, 5th, and 6th year of the PUMS 6-year M...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28521968/localized-myofascial-pain-responds-better-than-referring-myofascial-pain-to-botulinum-toxin-injections
#13
W A Abboud, S Hassin-Baer, M Joachim, N Givol, R Yahalom
Myofascial pain of the muscles of mastication is a common temporomandibular disorder. Patients unresponsive to conservative treatment modalities pose a therapeutic challenge to the treating clinician. The efficacy of intramuscular botulinum toxin injections for recalcitrant cases is still not well established due to mixed results from clinical trials. The Diagnostic Criteria of Temporomandibular Disorders (DC/TMD) classified chronic muscle pain broadly into a localized pattern (when pain is localized to the site of palpation or the muscle palpated) and a referring pattern (when the pain spreads beyond the boundary of the muscle being palpated)...
May 15, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28521729/self-rated-health-and-functional-capacity-in-individuals-reporting-overlapping-symptoms-of-gastroesophageal-reflux-disease-functional-dyspepsia-and-irritable-bowel-syndrome-a-population-based-study
#14
Dorte Ejg Jarbøl, Sanne Rasmussen, Kirubakaran Balasubramaniam, Sandra Elnegaard, Peter Fentz Haastrup
BACKGROUND: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functional gastrointestinal conditions with a significant impact on daily life. The objectives were to analyse general self-rated health and self-reported functional capacity in adults meeting the criteria for GERD, FD and IBS, respectively, and in individuals who meet the criteria for more than one of the conditions. METHODS: A nationwide study of 100,000 individuals aged 20 years and above, randomly selected in the general Danish population...
May 18, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28521652/case-report-patient-with-unexplained-high-fever-and-pancytopenia
#15
Kelly De Schuyter, Tom Lodewyck
OBJECTIVE AND IMPORTANCE: We present a case of hemophagocytic lymphohistiocytosis (HLH), giving insight in how to establish diagnosis and start appropiate treatment. CLINICAL PRESENTATION: A 45-year-old male presented at the emergency ward with high fever and pancytopenia. Repeat bone marrow aspirates showed hemophagocytosis. Extensive work-up with exclusion of other infectious and malignant diseases, eventually lead us to the diagnosis of hemophagocytic lymphohistiocytosis...
May 19, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28521284/cytokine-mediated-activation-of-human-ex-vivo-expanded-v%C3%AE-9v%C3%AE-2-t-cells
#16
Eisuke Domae, Yuya Hirai, Takashi Ikeo, Seiji Goda, Yoji Shimizu
Vγ9Vδ2 T cells, the major subset of the human peripheral blood γδ T-cell, respond to microbial infection and stressed cells through the recognition of phosphoantigens. In contrast to the growing knowledge of antigen-mediated activation mechanisms, the antigen-independent and cytokine-mediated activation mechanisms of Vγ9Vδ2 T cells are poorly understood. Here, we show that interleukin (IL) -12 and IL-18 synergize to activate human ex vivo-expanded Vγ9Vδ2 T cells. Vγ9Vδ2 T cells treated with IL-12 and IL-18 enhanced effector functions, including the expression of IFN-γ and granzyme B, and cytotoxicity...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28520898/pyrenoid-loss-impairs-carbon-concentrating-mechanism-induction-and-alters-primary-metabolism-in-chlamydomonas-reinhardtii
#17
Madeline C Mitchell, Gergana Metodieva, Metodi V Metodiev, Howard Griffiths, Moritz T Meyer
Carbon-concentrating mechanisms (CCMs) enable efficient photosynthesis and growth in CO2-limiting environments, and in eukaryotic microalgae localisation of Rubisco to a microcompartment called the pyrenoid is key. In the model green alga Chlamydomonas reinhardtii, Rubisco preferentially relocalises to the pyrenoid during CCM induction and pyrenoid-less mutants lack a functioning CCM and grow very poorly at low CO2. The aim of this study was to investigate the CO2 response of pyrenoid-positive (pyr+) and pyrenoid-negative (pyr-) mutant strains to determine the effect of pyrenoid absence on CCM induction and gene expression...
May 18, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28518222/the-effect-of-initial-molecular-profile-on-response-to-recombinant-interferon-%C3%AE-rifn%C3%AE-treatment-in-early-myelofibrosis
#18
Richard T Silver, Ariella C Barel, Elena Lascu, Ellen K Ritchie, Gail J Roboz, Paul J Christos, Attilio Orazi, Duane C Hassane, Wayne Tam, Nicholas C P Cross
BACKGROUND: Although recombinant interferon-α (rIFNα) effectively treats patients with early myelofibrosis, the effect of driver and high molecular risk (HMR) mutations has not been considered. In this phase 2 study, for the first time, the authors correlate response to rIFNα treatment with driver and HMR mutations. METHODS: Patients were diagnosed using World Health Organization or International Working Group for Myeloproliferative Neoplasms Research and Treatment criteria...
May 18, 2017: Cancer
https://www.readbyqxmd.com/read/28516468/association-between-the-frequency-and-autonomy-of-social-participation-and-self-rated-health
#19
Kimiko Tomioka, Norio Kurumatani, Hiroshi Hosoi
AIM: Although numerous studies have reported that social participation (SP) has favorable effects on older people's health, no studies have focused on the autonomy of SP. We investigated the cross-sectional relationship between the type, frequency, and autonomy of SP and self-rated health (SRH). METHODS: A postal survey was mailed to 19 354 citizens born between 1945 and 1949 in a city in Nara prefecture (response rate: 65.9%). A total of 12 157 respondents (5114 men and 7043 women) with independent basic activities of daily living made up the analytical participants...
May 18, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28515591/the-current-status-of-pediatric-radiology-in-india-a-conference-based-survey
#20
Jacob Therakathu, Vikas K Yadav, Shyamkumar N Keshava, Sridhar Gibikote, Govind B Chavan, Manohar Shroff
INTRODUCTION: Like most other developing countries, India has a large proportion of children among its population. However, the facilities for adequate treatment of this large population is inadequate. The development of pediatric radiology as a subspecialty is still at an infant stage in India. The goal of our study was to assess the awareness about the current status of pediatric radiology in India. MATERIALS AND METHODS: A questionnaire was handed over to all attendees of a pediatric radiology conference to assess their opinion regarding the adequacy of pediatric training and practice in India...
January 2017: Indian Journal of Radiology & Imaging
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