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https://www.readbyqxmd.com/read/28944324/surgeons-approach-toward-clinical-nutrition-a-survey-based-study
#1
Bahadır Osman Bozkırlı, Rıza Haldun Gündoğdu, Soner Akbaba, Turgay Sayın, Pamir Eren Ersoy
OBJECTIVE: Although many surgical patients face postoperative problems due to a poor nutritional status, there is evidence that many cases of malnutrition still go unnoticed and untreated in surgical wards. This study aims to define the current attitudes of surgeons toward nutritional screening and support. MATERIAL AND METHODS: A questionnaire with 13 questions was e-mailed to 1500 surgeons. Cross-queries were made over the responses. RESULTS: The response rate was 20...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28944163/weathering-the-storm-improving-therapeutic-interventions-for-cytokine-storm-syndromes-by-targeting-disease-pathogenesis
#2
Lehn K Weaver, Edward M Behrens
Cytokine storm syndromes require rapid diagnosis and treatment to limit the morbidity and mortality caused by the hyperinflammatory state that characterizes these devastating conditions. Herein, we discuss the current knowledge that guides our therapeutic decision-making and personalization of treatment for patients with cytokine storm syndromes. Firstly, ICU-level supportive care is often required to stabilize patients with fulminant disease while additional diagnostic evaluations proceed to determine the underlying cause of cytokine storm...
March 2017: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28944157/problem-gambling-among-ethnic-minorities-results-from-an-epidemiological-study
#3
Kyle R Caler, Jose Ricardo Vargas Garcia, Lia Nower
A few studies have examined gambling behavior and problem gambling among minorities and reported higher rates of both participation and gambling problems among particular minority groups in comparison to Whites who gamble. The present study utilized a representative, epidemiological sample of adults in New Jersey to explore gambling behavior, gambling problem severity, substance use, problem behavior, and mental health issues among minorities. Univariate analyses were conducted, comparing Whites (n = 1341) to respondents who identified as Hispanic (n = 394), Black (n = 261), or Asian/other (n = 177)...
2017: Asian journal of gambling issues and public health
https://www.readbyqxmd.com/read/28944112/excellent-response-with-ado-trastuzumab-emtansine-in-a-patient-with-relapsed-metastatic-breast-cancer-presenting-with-pulmonary-lymphangitic-carcinomatosis
#4
Zhou Yu, Shobana Sankar, Marianne Huben
In breast cancer, aggressive tumor biology and the corresponding poor prognosis is associated with amplification or overexpression of the human epidermal growth factor receptor 2 (HER2). Trastuzumab has significantly changed the natural history of HER2-positive breast cancer. However, resistance to trastuzumab remains a substantial clinical problem. Ado-trastuzumab emtansine (T-DM1), an antibody-drug conjugate, has demonstrated impressive results in second- or later-line treatment of HER2-positive breast cancer...
July 14, 2017: Curēus
https://www.readbyqxmd.com/read/28943423/long-term-efficacy-of-nerve-combing-for-the-patients-with-trigeminal-neuralgia-who-failed-prior-microvascular-decompression
#5
Xin Zhang, Ling Xu, Hua Zhao, Yin-Da Tang, Jin Zhu, Yan Yuan, Ping Zhou, Shi-Ting Li
BACKGROUND: Microvascular decompression (MVD) of the trigeminal nerve is the most effective treatment for trigeminal neuralgia (TN). However, there are many patients responded poorly to initial MVD. For those patients, redo MVD is the common method. At present, there has been no research regarding the effective of nerve combing (NC) plus MVD for TN patients who failed prior MVD. In this study, we compare the clinical outcome of NC plus MVD and simple MVD for those cases. METHODS: We performed a retrospective analysis of 148 patients with recurrent or persistent TN symptoms who underwent surgery at our hospital between January 2007 and December 2015...
September 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28942731/factors-influencing-trainee-doctor-emigration-in-a-high-income-country-a-mixed-methods-study
#6
Nicholas Clarke, Sophie Crowe, Niamh Humphries, Ronan Conroy, Simon O'Hare, Paul Kavanagh, Ruairi Brugha
BACKGROUND: The Global Code of Practice on the International Recruitment of Health Personnel focuses particularly on migration of doctors from low- and middle-income countries. Less is understood about migration from high-income countries. Recession has impacted several European countries in recent years, and in some cases emigration has reached unprecedented levels. This study measures and explores the predictors of trainee doctor emigration from Ireland. METHODS: Using a partially mixed sequential dominant (quantitative) study design, a nationally representative sample of 893 trainee doctors was invited to complete an online survey...
September 25, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28942016/positron-emission-tomography-based-assessment-of-metabolic-tumor-volume-predicts-survival-after-autologous-hematopoietic-cell-transplantation-for-hodgkin-lymphoma
#7
Vít Procházka, Rakhee S Gawande, Zuzan Cayci, Jerry W Froelich, Qing Cao, Chris Wilke, Kathryn Dusenbery, Daniel J Weisdorf, Veronika Bachanova
Autologous hematopoietic cell transplantation (AHCT) is curative for 60% of patients with relapsed or refractory Hodgkin lymphoma (R/R HL). A more precise assessment of the depth of remission prior to AHCT may help to identify patients likely to benefit from AHCT. We aimed to determine whether PET-based quantitative parameters of total metabolic tumor volume (TMTV), total lesion glycolysis (TLG), and maximal standardized uptake volume (SUVmax) measured prior to AHCT predict progression-free survival (PFS) after transplant...
September 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28941220/coping-strategies-psychological-impact-and-support-preferences-of-men-with-rheumatoid-arthritis-a-multicentre-survey
#8
Caroline A Flurey, Sarah Hewlett, Karen Rodham, Alan White, Robert Noddings, John R Kirwan
OBJECTIVES: To investigate the existence and distribution of two typologies (termed 'Factors') of men with RA identified through our previous Q-methodology study (n=30) in a larger sample of men with RA, and whether differences in psychosocial impact or support preferences exist between the two factors, and between men and women with RA. METHODS: A postal survey was sent to 620 men with RA from 6 rheumatology units across England, and the support preferences section of the survey was given to 232 women with RA...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28941151/recurrent-desmoplastic-small-round-cell-tumor-responding-to-an-mtor-inhibitor-containing-regimen
#9
Nidale Tarek, Andrea Hayes-Jordan, Laura Salvador, Mary F McAleer, Cynthia E Herzog, Winston W Huh
Desmoplastic small round cell tumor (DSRCT) is a rare mesenchymal tumor that typically presents with multiple abdominal masses. Initial treatment is multimodal in nature. Patients with relapsed DSRCT have a poor prognosis, and there are no standard therapies. We report our experience with five patients treated with vinorelbine, cyclophosphamide, and temsirolimus (VCT). Median number of VCT courses delivered was 7 (range 4-14 courses), and partial response was observed in all patients. Median time to progression or relapse was 8...
September 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28941150/brentuximab-vedotin-exerts-profound-antiproliferative-and-pro-apoptotic-efficacy-in-cd30-positive-as-well-as-cocultured-cd30-negative-germ-cell-tumour-cell-lines
#10
Stefan Schönberger, Cornelius van Beekum, Barbara Götz, Daniel Nettersheim, Hubert Schorle, Dominik T Schneider, Anna Casati, Rogerio B Craveiro, Gabriele Calaminus, Dagmar Dilloo
Prognosis in patients suffering from high-risk, refractory and relapsed germ cell tumours (GCT) often comprising of CD30-positive embryonal carcinoma (EC) components remains poor. Thus, novel treatment strategies are warranted. The antibody-drug conjugate (ADC) brentuximab vedotin delivers the potent antimitotic drug monomethyl auristatin E (MMAE) to CD30-expressing tumour cells. After CD30 binding, internalization and intracellular linker cleavage cytotoxic MMAE can efflux and eradicate neighbouring CD30-negative cells...
September 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28940539/financial-and-health-barriers-and-caregiving-related-difficulties-among-rural-and-urban-caregivers
#11
Erin D Bouldin, Lynn Shaull, Elena M Andresen, Valerie J Edwards, Lisa C McGuire
PURPOSE: To assess whether financial or health-related barriers were more common among rural caregivers and whether rural caregivers experienced more caregiving-related difficulties than their urban peers. METHODS: We used data from 7,436 respondents to the Caregiver Module in 10 states from the 2011-2013 Behavioral Risk Factor Surveillance System. Respondents were classified as caregivers if they reported providing care to a family member or friend because of a long-term illness or disability...
September 23, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28940254/nowhere-to-hide-effects-of-linear-features-on-predator-prey-dynamics-in-a-large-mammal-system
#12
Craig A DeMars, Stan Boutin
Rapid landscape alteration associated with human activity is currently challenging the evolved dynamical stability of many predator-prey systems by forcing species to behaviorally respond to novel environmental stimuli. In many forested systems, linear features (LFs) such as roads, pipelines and resource exploration lines (i.e. seismic lines) are a ubiquitous form of landscape alteration that have been implicated in altering predator-prey dynamics. One hypothesized effect is that LFs facilitate predator movement into and within prey refugia, thereby increasing predator-prey spatial overlap...
September 22, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28940023/cells-of-origin-of-ovarian-cancer-ovarian-surface-epithelium-or-fallopian-tube
#13
REVIEW
Daniel Martin Klotz, Pauline Wimberger
OBJECTIVE: Ovarian cancer is the fifth most common cancer in women and one of the leading causes of death from gynecological malignancies. Despite of its clinical importance, ovarian tumorigenesis is poorly understood and prognosis remains poor. This is particularly true for the most common type of ovarian cancer, high-grade serous ovarian cancer. RESULTS: Two models are considered, whether it arises from the ovarian surface epithelium or from the fallopian tube...
September 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28939560/plastic-responses-of-bryozoans-to-ocean-acidification
#14
Daniel S Swezey, Jessica R Bean, Tessa M Hill, Brian Gaylord, Aaron T Ninokawa, Eric Sanford
Phenotypic plasticity has the potential to allow organisms to respond rapidly to global environmental change, but the range and effectiveness of these responses are poorly understood across taxa and growth strategies. Colonial organisms might be particularly resilient to environmental stressors, as organizational modularity and successive asexual generations can allow for distinctively flexible responses in the aggregate form. We performed laboratory experiments to examine the effects of increasing dissolved carbon dioxide (i...
September 22, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28939454/outcome-and-minimal-residual-disease-monitoring-in-t-16-21-acute-myeloid-leukemia-patients-receiving-allogeneic-hematologic-stem-cell-transplantation
#15
Ya-Zhen Qin, Yao Chen, Lan-Ping Xu, Yu Wang, Xiao-Hui Zhang, Huan Chen, Xiao-Su Zhao, Kai-Yan Liu, Xiao-Jun Huang
Patients with t(16;21) acute myeloid leukemia (AML) who receive chemotherapy have poor outcomes. The treatment efficacy of allogeneic hematologic stem cell transplantation (allo-HSCT) must be identified, and the usefulness of minimal residual disease (MRD) monitoring requires evaluation. Fourteen t(16;21) AML patients consecutively receiving allo-HSCT at our institute were included in this study. The TLS-ERG transcript levels were serially monitored for a median of 15 (3-51) months after allo-HSCT. Eight patients relapsed, 7 patients died from relapse-related causes, and 1 patient died from a non-relapse-related cause...
September 19, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28939210/toward-a-blood-borne-biomarker-of-chronic-hypoxemia-red-cell-distribution-width-and-respiratory-disease
#16
Joseph W Yčas
Hypoxemia (systemic oxygen desaturation) marks the presence, risk, and progression of many diseases. Episodic or nocturnal hypoxemia can be challenging to detect and quantify. A sensitive, specific, and convenient marker of recent oxygen desaturation represents an unmet medical need. Observations of acclimatization to high altitude in humans and animals reveals several proteosomic, ventilatory, and hematological responses to low oxygen tension. Of these, increased red cell distribution width (RDW) appears to have the longest persistence...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28938895/-it-is-good-to-take-her-early-to-the-doctor-mothers-understanding-of-childhood-pneumonia-symptoms-and-health-care-seeking-in-kilimanjaro-region-tanzania
#17
Florida Muro, Judith Meta, Jenny Renju, Adiel Mushi, Hilda Mbakilwa, Raimos Olomi, Hugh Reyburn, Helena Hildenwall
BACKGROUND: Pneumonia is among the leading causes of avoidable deaths for young children globally. The main burden of mortality falls on children from poor and rural families who are less likely to obtain the treatment they need, highlighting inequities in access to effective care and treatment. Caretakers' illness perceptions and care-seeking practices are of major importance for children with pneumonia to receive adequate care. This study qualitatively explores the caretaker concepts of childhood pneumonia in relation to treatment seeking behaviour and health worker management in Moshi urban district, Tanzania...
September 22, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28938543/predictive-clinical-model-of-tumor-response-after-chemoradiation-in-rectal-cancer
#18
Marisa D Santos, Cristina Silva, Anabela Rocha, Carlos Nogueira, Fernando Castro-Poças, António Araujo, Eduarda Matos, Carina Pereira, Rui Medeiros, Carlos Lopes
Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937068/knowledge-of-acute-kidney-injury-among-nurses-in-two-government-hospitals-in-ondo-city-southwest-nigeria
#19
Oluseyi A Adejumo, Ayodeji A Akinbodewa, Oladimeji E Alli, Olufemi B Pirisola, Olatunji S Abolarin
Adequate knowledge of acute kidney injury (AKI) among all health-care providers is essential for early diagnosis and management to reduce the associated burden. This study determined the knowledge of AKI among nurses in two government hospitals in Ondo City, Southwest Nigeria. This cross-sectional descriptive study was carried out in two government hospitals in Ondo City using a self-administered pretested questionnaire that assessed knowledge of AKI and associated factors. A total of 156 respondents participated in the study...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28935292/clinical-significance-of-reversal-of-flow-in-the-vertebral-artery-identified-on-cerebrovascular-duplex-ultrasound
#20
Aleksandra Policha, Melissa Baldwin, Victoria Lee, Mark A Adelman, Caron Rockman, Todd Berland, Neal S Cayne, Thomas S Maldonado
BACKGROUND: Reversal of flow in the vertebral artery (RFVA) is an uncommon finding on cerebrovascular duplex ultrasound examination. The clinical significance of RFVA and the natural history of patients presenting with it are poorly understood. Our objective was to better characterize the symptoms and outcomes of patients presenting with RFVA. METHODS: A retrospective review was performed of all cerebrovascular duplex ultrasound studies performed at our institution between January 2010 and January 2016 (N = 2927 patients)...
September 18, 2017: Journal of Vascular Surgery
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