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https://www.readbyqxmd.com/read/28738542/protective-effects-of-tannic-acid-on-acute-doxorubicin-induced-cardiotoxicity-involvement-of-suppression-in-oxidative-stress-inflammation-and-apoptosis
#1
Jianping Zhang, Lijing Cui, Xue Han, Yuanyuan Zhang, Xuan Zhang, Xi Chu, Fenghua Zhang, Ying Zhang, Li Chu
Doxorubicin (DOX) is a highly effective drug, but its cardiotoxicity restricts its therapeutic index. Oxidative stress is the major etiopathological factor in DOX-induced cardiotoxicity. Tannic acid (TA) has various anti-cancer, antioxidant, and anti-inflammatory activities. The purpose of the study was to survey the possible effects of TA against acute DOX-induced cardiotoxicity. Male Sprague-Dawleyrats were randomly divided into five groups: control, DOX (10mg/kg) alone, DOX with TA (20 and 40mg/kg), or DOX withcaptopril (30mg/kg) treatments...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738538/diosmin-improved-cognitive-deficit-and-amplified-brain-electrical-activity-in-the-rat-model-of-traumatic-brain-injury
#2
Mohammad Ali Mirshekar, Hamed Fanaei, Fereshteh Keikhaei, Fatemeh Sargolzaee Javan
OBJECTIVE: Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities in humans. Clinically, it is essential to limit the progress of cognitive impairment after TBI. It is reported that diosmin has a neuroprotective effect that can limit the progress of the impairment. The aim of this study was to evaluate the effects of diosmin on neurological score, memory, tumor necrosis factor-α (TNF-α) level and long-term potentiation in hippocampal dentate gyrus after the injury...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738487/-circadian-blood-pressure-characteristics-in-hospitalized-unstable-angina-pectoris-patients-with-hypertension
#3
W Zhang, H Zhu, S Y Yao, Y Li, J Liu, H Xue
Objective: To define the characteristic of circadian rhythm of blood pressure in unstable angina pectoris (UAP)patients with hypertension and its effects on the cardiovascular events. Methods: It was a prospective study.Based on coronary angiographic results, 742 consecutive hospitalized UAP patients with hypertension and 89 consecutive hospitalized hypertensive patients were recruited between September 2014 and December 2015 in this study. Clinical data and the results of 24-hour ambulatory blood pressure monitoring (ABPM) were analyzed...
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28738467/-epidemiological-survey-of-prevalence-of-hiv-infection-syphilis-and-hepatitis-c-in-female-sex-workers-and-other-6-risk-populations-in-tibet-autonomous-region
#4
S Lu, Y Cui, W Guo, D M Li, J Sun
Objective: To understand the prevalence of HIV infection, syphilis and hepatitis C and related behavioral factors in female sex workers (FSWs) and other 6 risk populations in Tibet Autonomous Region. Methods: A cross-sectional survey was conducted among 2 000 FSWs, 200 men who have sex with men (MSM), 200 drug users, 1 200 male migrants, 5 600 young students, as well as hospital patients and pregnant women in Lhasa, Qamdo, Nyingchi, Xigaze Shannan, Ali and Nagqum from June to December 2015. Face to face interviews were conducted to collect their demographic and behavioral information, and blood samples were collected for the tests of HIV, syphilis and hepatitis C virus (HCV) antibodies...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738466/-a-large-scale-cohort-study-on-aids-in-communities-in-dali-yunnan-province-2014-2015
#5
M Y Xiao, X M Chen, Y L Ma, L R Fu, J Niu, Z J Chen, H Y Li, Q L Wang, L J Song, H B Luo
Objective: To understand HIV incidence in community residents and epidemiological characteristics of newly detected HIV infection cases in Dali, Yunnan province. Methods: A cohort study was conducted among 146 720 community residents who were tested to be HIV negative during 2010-2011, they were followed-up from June 1, 2014 to May 31, 2015. Results: A total of 136 356 community residents received follow up (92.9%). The follow-up time was 0.23-5.40 years (medium: 3.43 years), cumulatively 459 675 person years, and 78 people were found to be HIV positive...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738462/-risk-factors-of-gout-in-jinchang-cohort-a-cox-regression-analysis
#6
C L He, N Cheng, Y M Rong, H Y Li, J S Li, J Ding, X B Hu, H Q Pu, X W Ren, Y N Bai
Objective: To explore the incidence and risk factors of gout in Jinchang cohort and provide scientific evidence for the prevention and control of gout. Methods: People without gout detected by baseline survey in Jinchang cohort were selected as study subjects. All the subjects were followed up through questionnaire interview, physical examination as well as laboratory test from January 24, 2013 to November 24, 2015. Cox regression model was used to analyze the risk factors for gout in Jinchang cohort. In addition, log-linear model was used to analyze the interaction between risk factors...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738356/thermal-preconditioning-may-prevent-tendon-adhesion-by-up-regulating-hsp72-in-rats
#7
Yang Tan, Qin-Fen Wu, Qiang Wu, Xin-Ti Tan, Liao-Bin Chen, Xin Wang
BACKGROUND/AIMS: The study aims to determine the effects of thermal preconditioning on tendon adhesion by regulating the expression of heat shock protein 72 (HSP72) in rat models. METHODS: Sixty male Wistar rats were collected and randomly assigned into the thermal preconditioning and control groups. During the 4th and 8th weeks following surgery, 15 rats were sacrificed in each period respectively, and their tendon adhesion was observed and evaluated. Biomechanical testing was performed to measure the tensile strength and gliding distance of tendons...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28738286/emodin-suppresses-cadmium-induced-osteoporosis-by-inhibiting-osteoclast-formation
#8
Xiao Chen, Shuai Ren, Guoying Zhu, Zhongqiu Wang, Xiaolin Wen
Environmental level of cadmium (Cd) exposure can induce bone loss. Emodin, a naturally compound found in Asian herbal medicines, could influence osteoblast/osteoclast differentiation. However, the effects of emodin on Cd-induced bone damage are not clarified. The aim of this study was to investigate the role of emodin on Cd-induced osteoporosis. Sprague-Dawley male rats were divided into three groups which were given 0mg/L, 50mg Cd/L and 50mg Cd/L plus emodin (50mg/kg body weight). Bone histological investigation, microCT analysis, metabolic biomarker determination and immunohistochemical staining were performed at the 12th week...
July 18, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28738259/reasons-associated-with-treatment-non-adherence-in-schizophrenia-in-a-pakistan-cohort
#9
Irshad Ahmad, Muhammad Tahir Khalily, Brian Hallahan
non-adherence in patients with schizophrenia is the most common reason for a relapse of psychosis. In a cohort of participants in Pakistan who suffered a relapse of psychosis, we aimed to identify the principal factors associated with non-adherence, including any culture specific factors that might not be as significant in other jurisdictions. Semi-structured interviews were undertaken at four psychiatric hospitals in the Peshawar region in Pakistan with 55 participants (44 male and 11 female) diagnosed with schizophrenia, who had suffered a relapse of psychosis subsequent to treatment non-adherence...
July 13, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28738246/crocin-modulates-il-4-il-13-signaling-and-ameliorates-experimentally-induced-allergic-airway-asthma-in-a-murine-model
#10
Haidy Yosri, Wagdi F Elkashef, Eman Said, Nariman M Gameil
Allergic asthma is a chronic respiratory disease with a prevalent T helper (Th2)-mediated immune reaction. Crocin, the major bioactive constituent of saffron, has been reported in multiple studies to have numerous pharmacological activities, including prominent anti-oxidant activities. In the current study, the anti-asthmatic potential of crocin was evaluated. Adult male Swiss Albino mice were administered 10mg of ovalbumin (OVA) mixed with 1mg of aluminum hydroxide intraperitoneally on days 0 and 7 and were administered crocin (25mg/kg) orally daily for 16days...
July 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28738193/degree-of-keratinization-is-an-independent-prognostic-factor-in-oral-squamous-cell-carcinoma
#11
Susanne Wolfer, Stefan Elstner, Stefan Schultze-Mosgau
PURPOSE: Keratinization is a routinely reported histologic feature in head and neck cancer. In contrast to numerous clinicopathologic parameters, the prognostic value of keratinization in oral squamous cell carcinoma (OSCC) is rarely reported in the literature. The purpose of this study was to review the outcome of patients with OSCC with a special focus on the degree of keratinization. PATIENTS AND METHODS: In this retrospective cohort study, we evaluated the medical records at the Department of Oral and Maxillofacial Surgery, Jena University Hospital, and investigated the outcome of patients with OSCC with disease-free survival and disease-specific survival according to the degree of keratinization...
June 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28738121/incidence-risks-and-types-of-infections-in-pediatric-long-term-care-facilities
#12
Lisa Saiman, Philip Maykowski, Meghan Murray, Bevin Cohen, Natalie Neu, Haomioa Jia, Gordon Hutcheon, Edwin Simpser, Linda Mosiello, Luis Alba, Elaine Larson
Importance: The population of infants, children, and adolescents cared for at pediatric long-term care facilities is increasing in complexity and size and thus consumes substantial health care resources. Infections are a significant cause of morbidity and mortality in this population, but few recent data describe their incidence and effects. Objectives: To describe the types of infections diagnosed in residents of pediatric long-term care facilities, calculate infection rates, and identify risk factors for respiratory tract infections (RTIs)...
July 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28738014/enhancer-of-zeste-homologue-2-ezh2-expression-in-synovial-sarcomas-as-a-promising-indicator-of-prognosis
#13
Ulviye Yalçınkaya, Nesrin Uğraş, Gonca Özgün, Gökhan Ocakoğlu, Adem Deligönül, Sibel Kahraman Çetintaş, Muhammed Sadık Bilgen
Synovial sarcoma (SS) is a type of soft tissue sarcoma, often linked to poor survival. Although overexpression of enhancer of zeste homologue 2 (EZH2) has been associated with poor prognosis in different tumors, a few studies investigated this link in SS. Here, we analyzed the relationship between EZH2 expression and prognostic factors in SS. We included 29 patients with SS. Immunostaining of EZH2 was performed with (D2C9) XPTM Rabbit mAb antibody, and the results were classified as low EZH2 expression (negative or weak expression) and high EZH2 expression category (moderate or strong expression)...
July 24, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28737959/influence-of-patient-related-factors-on-number-of-mesenchymal-stromal-cells-reached-after-in-vitro-culture-expansion-for-clinical-treatment
#14
Abbas Ali Qayyum, Kamal Preet Kaur, Anders Bruun Mathiasen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup
BACKGROUND: Number of stromal cells injected in patients with ischaemic heart disease (IHD) may be of importance for the treatment efficacy, which in turn may be influenced by various patient-related factors. In this study, we investigate whether patient-related factors influence the number of autologous stromal cells reached after in vitro culture expansion for clinical therapy. METHODS: Culture expansion data from 111 patients with IHD treated with autologous stromal cells in three clinical trials were used...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28737874/-brain-abscess-in-children-ten-years-of-experience-in-a-third-level-pediatric-hospital
#15
Martín Brizuela, Guadalupe Pérez, Soledad Martiren, Ana N Varela Baino, Carola Cedillo, Silvina Ruvinsky, Carolina Epelbaum, Adela Isasmendi, Mirta Litterio, José L Pinheiro, Rosa Bologna
Brain abscess is a focal infection that occurs with a frequency of 0.3-1.3 cases per 100,000 people/year. We describe the epidemiology, clinical and microbiology characteristics of 38 children diagnosed with brain abscess hospitalized between 4/1/2005 and 12/31/2015 at Hospital de Pediatría "Prof. Dr. Juan P. Garrahan" in Buenos Aires City. Twenty-four patients were male. The median age was 132 months. Predisposing factors were detected in 25 children. The median evolution from onset of symptoms to the visit was 7 days...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737591/hiv-incidence-and-predictors-of-hiv-acquisition-from-an-outside-partner-in-serodiscordant-couples-in-lusaka-zambia-1995-2012
#16
Dvora L Joseph Davey, Kristin M Wall, William Kilembe, Htee Khu Naw, Ilene Brill, Bellington Vwalika, Elwyn Chomba, Joseph Mulenga, Amanda Tichacek, Marjan Javanbakt, Pamina Gorbach, Susan Allen
OBJECTIVE: Evaluate the incidence and predictors of HIV acquisition from outside partners in serodiscordant couples. METHODS: Demographic, behavioral, and clinical exposures were measured quarterly in a cohort of serodiscordant cohabiting couples in Zambia from 1995-2012 (n=3049). Genetic analysis classified incident infections as those acquired from the study partner (linked) or acquired from an outside partner (unlinked). Factors associated with time to unlinked HIV infection were evaluated using multivariable Cox proportional hazards regression stratified by gender...
July 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28737507/leukotrienes-and-sex-strange-bedfellows
#17
Lewis J Smith
Leukotrienes are proinflammatory lipid mediators that have been shown to be upregulated in several diseases, including asthma, aspirin-exacerbated respiratory disease (AERD), inflammatory bowel disease, and acute respiratory distress syndrome. Leukotrienes have been explored as therapeutic targets for these diseases and others; however, leukotriene inhibitors have had limited success in the clinic. There are noted differences in the incidence of leukotriene-mediated diseases in males and females, but sex as a factor in the response to leukotriene inhibitors has not been fully explored...
July 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28737505/androgen-mediated-sex-bias-impairs-efficiency-of-leukotriene-biosynthesis-inhibitors-in-males
#18
Simona Pace, Carlo Pergola, Friederike Dehm, Antonietta Rossi, Jana Gerstmeier, Fabiana Troisi, Helmut Pein, Anja M Schaible, Christina Weinigel, Silke Rummler, Hinnak Northoff, Stefan Laufer, Thorsten J Maier, Olof Rådmark, Bengt Samuelsson, Andreas Koeberle, Lidia Sautebin, Oliver Werz
Proinflammatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FLAP). LT biosynthesis inhibitors are currently under clinical investigation as treatments for respiratory and cardiovascular diseases. Here, we have revealed a sex bias in the efficiency of clinically relevant LT biosynthesis inhibitors, showing that their effects are superior in females. We found that androgens cause these sex differences by impeding the LT-biosynthetic 5-LO/FLAP complex assembly. Lower doses of the FLAP inhibitor MK886 were required to reduce LTB4 levels in exudates of female versus male mice and rats...
July 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28737485/risk-taking-during-feeding-between-and-within-population-variation-and-repeatability-across-contexts-among-wild-zebrafish
#19
Tamal Roy, Rohitashva Shukla, Anuradha Bhat
Behavioral responses are shaped by a complex interplay of extrinsic factors, such as predation and flow conditions, and intrinsic properties such as metabolic state. We investigated variations in boldness among four populations of zebrafish collected from widely varying habitat conditions across India. We measured feeding latencies of fish in four contexts: in a novel environment; in an environment with refuge and predators; in the presence of a shoal; and in the presence of a shoal and predators. The population from a high-flow and high-predation habitat was significantly bolder than populations from low-predation and low-flow/stagnant habitats...
July 24, 2017: Zebrafish
https://www.readbyqxmd.com/read/28737273/recovery-free-of-heart-failure-after-acute-coronary-syndrome-and-coronary-revascularization
#20
Alec Falkenham, Manu K Saraswat, Chloe Wong, Kareem Gawdat, Tanya Myers, Jahanara Begum, Karen J Buth, Ian Haidl, Jean Marshall, Jean-Francois Légaré
AIMS: Previous studies have examined risk factors for the development of heart failure (HF) subsequent to acute coronary syndrome (ACS). Our study seeks to clarify the clinical variables that best characterize patients who remain free from HF after coronary artery bypass grafting (CABG) surgery for ACS to determine novel biological factors favouring freedom from HF in prospective translational studies. METHODS AND RESULTS: Nova Scotia residents (1995-2012) undergoing CABG within 3 weeks of ACS were included...
July 24, 2017: ESC Heart Failure
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