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https://www.readbyqxmd.com/read/29892142/ovarian-hyperstimulation-syndrome-a-narrative-review-of-its-pathophysiology-risk-factors-prevention-classification-and-management
#1
REVIEW
Bahia Namavar Jahromi, Mohammad Ebrahim Parsanezhad, Zahra Shomali, Pardis Bakhshai, Mahshid Alborzi, Najmeh Moin Vaziri, Zahra Anvar
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovulation induction that usually occurs after gonadotropin stimulation, followed by human chorionic gonadotropin administration, for infertility treatment. The existing knowledge about the pathophysiology, risk factors, and primary and secondary methods for the prevention of OHSS is reviewed in this manuscript. The clinical manifestations and characteristics of mild, moderate, severe, and critical forms of the syndrome are defined. The methods of handling affected cases as outpatient or in-hospital management methods as well as indications for hospitalization are summarized in this review...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29881888/clinical-outcomes-of-frozen-embryo-versus-fresh-embryo-transfer-following-in-vitro-fertilization-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Wanlin Zhang, Xifeng Xiao, Junyan Zhang, Wenjun Wang, Jing Wu, Ling Peng, Xiaohong Wang
PURPOSE: To examine available data from randomized controlled trials to assess if the freeze-all embryo and subsequent frozen-thawed embryo transfer (FET) results in better clinical outcomes than fresh embryo transfer (ET). METHODS: Meta-analysis. RESULTS: We conducted an electronic literature search on PubMed and Embase databases and manually supplemented another 2 articles from relevant citations. Seven studies were finally included in the meta-analysis,including 1141 women who underwent fresh embryo transfer and 1079 who underwent frozen embryo transfer...
June 7, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29880170/the-effects-of-resveratrol-on-ovarian-hyperstimulation-syndrome-in-a-rat-model
#3
Sebnem Ozgur, Mesut Oktem, S Ozlem Altinkaya, Emel Ozalp Oktem, Cahit Cenksoy, Ozlem Erdem, Sehri Elbeg, Ayse Helvaci, Ahmet Erdem, Mehmet Erdem
OBJECTIVE: The aim of the present study was to investigate effects of resveratrol (RSV) over ovarian hyperstimulation syndrome (OHSS) in rat model. MATERIALS AND METHODS: 24 female Wistar rats (22 days old) were divided into four groups. Group 1 (control group; n = 6) received 0.1 ml intraperitoneal (IP) saline from days 22-26; group 2 (mild-stimulated group; n = 6) received 10 IU pregnant mare serum gonadotropin (PMSG) on day 24 and 10 IU of hCG 48 h later (day 26); group 3 (OHSS group; n = 6) was given 10 IU of PMSG for 4 consecutive days from day 22 and 30 IU hCG on the fifth day to induce OHSS; group 4 (OHSS + RSV group; n = 6) was treated the same as group 3, but received 60 mg/kg RSV 2 h before PMSG injection for 4 consecutive days and 2 h before the hCG injection on the fifth day...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29869218/genome-wide-screening-differential-long-non-coding-rnas-expression-profiles-discloses-its-roles-involved-in-ohss-development
#4
Haiyan Lin, Yu Li, Weijie Xing, Qi Qiu, Wenjun Wang, Qingxue Zhang
OBJECTIVE: To screen differentially expressed lncRNAs involved in OHSS. OHSS is defined as ovarian hyperstimulation syndrome. It is characterized as enlarged ovary and increased vascular permeability. DESIGN: Case-control study. SETTING: University-affiliated hospital. PATIENT(S): Patients with OHSS high risk (n = 30) and low risk (n = 30) were included in this study. INTERVENTION(S): None...
June 4, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29843716/the-vegf-and-pedf-levels-in-the-follicular-fluid-of-patients-co-treated-with-letrozole-and-gonadotropins-during-the-stimulation-cycle
#5
Jigal Haas, Rawad Bassil, Noa Gonen, Jim Meriano, Andrea Jurisicova, Robert F Casper
BACKGROUND: Previous studies have shown that androgens, in addition to serving as precursors for ovarian estrogen synthesis, also have a fundamental role in primate ovarian follicular development by augmentation of FSH receptor expression on granulosa cells. Recent studies have shown that aromatase inhibitor, letrozole, improves ovarian response to FSH in normal and poor responder patients, possibly by increasing intraovarian androgen levels. Studies in mice also showed an effect of letrozole to increase pigment epithelium-derived factor (PEDF) and to lower vascular epithelial growth factor (VEGF), which might be expected to reduce the risk of ovarian hyperstimulation syndrome (OHSS) with stimulation...
May 29, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29807533/progestin-primed-milder-stimulation-with-clomiphene-citrate-yields-fewer-oocytes-and-suboptimal-pregnancy-outcomes-compared-with-the-standard-progestin-primed-ovarian-stimulation-in-infertile-women-with-polycystic-ovarian-syndrome
#6
Hongjuan Ye, Hui Tian, Wen He, Qifeng Lyu, Yanping Kuang, Qiuju Chen, Lihua Sun
BACKGROUND: Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed ovarian stimulation (PPOS) is effective and safe in patients with different ovarian reserves. The current data are lacking regarding how to individualize the gonadotropin dose and regimen for women with polycystic ovarian syndrome (PCOS). A retrospective cohort trial was performed to evaluate the efficacy of progestin-primed milder stimulation with clomiphene citrate (CC) compared to the standard progestin-primed ovarian stimulation (PPOS) protocol for infertile women with PCOS...
May 28, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29797697/aromatase-inhibitors-letrozole-for-subfertile-women-with-polycystic-ovary-syndrome
#7
REVIEW
Sebastian Franik, Stephanie M Eltrop, Jan Am Kremer, Ludwig Kiesel, Cindy Farquhar
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common cause of infrequent periods (oligomenorrhoea) and absence of periods (amenorrhoea). It affects about 4% to 8% of women worldwide and often leads to anovulatory subfertility. Aromatase inhibitors (AIs) are a class of drugs that were introduced for ovulation induction in 2001. Since about 2001 clinical trials have reached differing conclusions as to whether the AI letrozole is at least as effective as the first-line treatment clomiphene citrate (CC)...
May 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29781072/ascites-index-a-novel-technique-to-evaluate-ascites-in-ovarian-hyperstimulation-syndrome-a-concept-proof-study
#8
Piotr Robert Szkodziak, Piotr Czuczwar, Wojciech Wrona, Tomasz Paszkowski, Filip Szkodziak, Sławomir Woźniak
OBJECTIVES: Controlled ovarian hyperstimulation is an important step in infertility treatment. In some cases, however, ovar-ian hyperstimulation syndrome (OHSS) can occur. In its severe forms, ascites is likely to develop, associated with dyspnea. The aim of this study was to explore the usefulness of Ascites Index (AsI), a new tool for quantitative determination of ascites in patients with OHSS, to obtain data for planning further trials. MATERIAL AND METHODS: Twelve patients with OHSS and ascites were included in the study...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29730813/predictive-factors-of-gestational-diabetes-in-pregnancies-following-assisted-reproductive-technology-a-nested-case-control-study
#9
Azam Kouhkan, Mohammad E Khamseh, Ashraf Moini, Reihaneh Pirjani, Ameneh Ebrahim Valojerdi, Arezoo Arabipoor, Roya Hosseini, Hamid Reza Baradaran
PURPOSE: To evaluate predictive factors for gestational diabetes mellitus (GDM) in singleton pregnancy following assisted reproductive technology (ART). METHODS: This nested case-control study was performed during October 2016-June 2017. Pregnant women who conceived following ART procedures referred to infertility clinic were selected and categorized into GDM and non-GDM based on ADA/IAPDSG criteria. The study variables including age, educational status, first-degree family history of chronic diseases, systolic and diastolic blood pressure, previous obstetric and perinatal outcomes, infertility history, and ART cycle characteristics were collected from medical records...
May 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29718716/complex-chromosomal-aberrations-in-a-fetus-originating-from-oocytes-with-smooth-endoplasmic-reticulum-ser-aggregates
#10
Ioannis A Sfontouris, George T Lainas, Tryfon G Lainas, Efthimios Faros, Maria Banti, Katerina Kardara, Katerina Anagnostopoulou, Harris Kontos, George K Petsas, Efstratios M Kolibianakis
The presence of smooth endoplasmic reticulum aggregates (SERa) in the ooplasm is considered as the most severe oocyte dysmorphism due to its serious and potentially lethal outcomes in offspring. In the present case report, a couple underwent their first intracytoplasmic sperm injection (ICSI) cycle using a gonadotrophin releasing hormone (GnRH) antagonist protocol, followed by fetal ultrasound scanning and amniocentesis. SERa were observed in all oocytes retrieved. A singleton pregnancy was established. The second trimester fetal ultrasound scan revealed a female fetus with overlapping fingers in both hands, and amniocentesis was performed for the detection of chromosomal abnormalities...
May 2, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29714057/large-for-gestational-age-and-macrosomia-in-singletons-born-after-frozen-thawed-embryo-transfer-fet-in-assisted-reproductive-technology-art
#11
REVIEW
Sine Berntsen, Anja Pinborg
Increase in success rates with frozen embryo transfer (FET) and reduced risk of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancies has lead to a steady rise in FET. Further, FET is associated with lower risk of prematurity and low birth weight in singletons, when compared with fresh transfer. However, there is a growing concern of increased risk of large for gestational (LGA) and/or macrosomic children after FET. Macrosomic/LGA births have a higher risk of cesarean section, fetal hypoxia and stillbirth...
May 1, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29696918/-efficacy-of-acupuncture-as-adjunctive-treatment-on-infertility-patients-with-polycystic-ovary-syndrome
#12
Juan Xu, Yu Zuo
OBJECTIVE: To observe the efficacy differences between acupuncture combined with medication and medication alone for infertility patients with polycystic ovary syndrome (PCOS). METHODS: According to random number table, a total of 60 infertility patients with PCOS were randomly assigned into an observation group and a control group, 30 cases in each one. The patients in the control group were treated with diane-35 from the 3rd day into menstruation, and one menstrual cycle was taken as a session of treatment...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29696192/the-dual-trigger-study-rationale-and-study-design-of-a-prospective-double-blind-randomized-clinical-trial-comparing-pregnancy-rates-after-co-administration-of-low-dose-hcg-at-the-time-of-gnrh-agonist-trigger-or-35-h-later-for-the-prevention-of-ohss
#13
Daniel Griffin, Claudio Benadiva, Tara Budinetz, Carolina Sueldo, Andrea DiLuigi, John Nulsen, Lawrence Engmann
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of controlled ovarian stimulation. The use of gonadotropin releasing hormone (GnRH) agonist for the trigger of oocyte maturation is effective in the prevention of OHSS although it may result in a lower pregnancy rate. The use of adjuvant low dose human chorionic gonadotropin (hCG) at the time of trigger or at the time of oocyte retrieval may improve pregnancy rates. The goal of this dual trigger study is to evaluate the safety and efficacy of the use of low dose hCG administered at the time of GnRH agonist trigger or 35 h later as well as the potential impact on pregnancy rates...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29675483/fresh-versus-frozen-embryo-transfer-after-gonadotropin-releasing-hormone-agonist-trigger-in-gonadotropin-releasing-hormone-antagonist-cycles-among-high-responder-women-a-randomized-multi-center-study
#14
Abbas Aflatoonian, Mahnaz Mansoori-Torshizi, Maryam Farid Mojtahedi, Behrouz Aflatoonian, Mohammaad Ali Khalili, Mohammad Hossein Amir-Arjmand, Mehrdad Soleimani, Nastaran Aflatoonian, Homa Oskouian, Nasim Tabibnejad, Peter Humaidan
Background: The use of embryo cryopreservation excludes the possible detrimental effects of ovarian stimulation on the endometrium, and higher reproductive outcomes following this policy have been reported. Moreover, gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone (GnRH) antagonist cycles as a substitute for standard human chorionic gonadotropin trigger, minimizes the risk of ovarian hyperstimulation syndrome (OHSS) in fresh as well as frozen embryo transfer cycles (FET)...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29673660/comparison-of-antagonist-mild-and-long-agonist-protocols-in-terms-of-follicular-fluid-total-antioxidant-capacity
#15
Begum Aydogan Mathyk, Berna Aslan Cetin, Duygu Vardagli, Emel Zengin, Nigar Sofiyeva, Tulay Irez, Pelin Ocal
OBJECTIVE: A high dose of prolonged gonadotropins can yield higher numbers of oocytes and embryos. The high dose or prolonged regimens can be associated with ovarian hyperstimulation syndrome (OHSS), multiple gestations, emotional stress, economical burden and treatment dropout. In mild stimulation lower doses and shorter duration times of gonadotropin are used in contrast to the conventional long stimulation protocol in IVF. It has been proposed that supraphysiologic levels of hormones may adversely affect endometrium and oocyte/embryo...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29658351/high-estrogen-exposure-may-not-be-detrimental-on-endometrial-receptivity-in-women-with-pcos
#16
Cigdem Abide Yayla, Enis Ozkaya, Gulay Beydilli Nacak, Ilhan Sanverdi, Belgin Devranoglu, Evrim Bostanci Ergen, Cetin Kilicci, Tayfun Kutlu
The study aimed to assess the effect of high estrogen exposure and coasting on cycle outcome in women at risk for developing ovarian hyperstimulation syndrome (OHSS). Retrospective case-control study was conducted to figure out the outcomes of GnRH antagonist cycles in which women were at risk to develop OHSS. Women who underwent coasting (n = 100) were compared with a control group of women who did not undergo coasting (n = 287). Effect of endometrial estrogen exposure was determined by calculating area under curve of temporal estrogen measurements (AUCEM) through the cycle...
April 14, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29655999/ovarian-hyperstimulation-syndrome-leading-to-ventriculoperitoneal-shunt-malfunction-case-report
#17
Amit Azriel, Benjamin Fleming, Uri P Dior, Samuel Moscovici, Yuval Sufaro, Mohammed Awad, Kate Drummond
Ventriculoperitoneal shunt (VPS) insertion is a common neurosurgical procedure for hydrocephalus. Unfortunately, VPS malfunction is not uncommon, with an estimated cumulative rate of 32% at 5 years. As flow through the shunt is influenced by the pressure gradient between the ventricles and the peritoneal cavity, malfunction may be caused by elevated intra-abdominal pressure. We present a rare patient with ascites following ovarian hyperstimulation syndrome (OHSS) leading to shunt malfunction. OHSS is a potentially life-threatening complication of controlled ovarian stimulation caused by the administration of exogenous gonadotropins...
June 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29605411/efficacy-and-safety-of-pulsatile-gonadotropin-releasing-hormone-therapy-among-patients-with-idiopathic-and-functional-hypothalamic-amenorrhea-a-systematic-review-of-the-literature-and-a-meta-analysis
#18
Anastasios Tranoulis, Alexandros Laios, Andreas Pampanos, Drakoulis Yannoukakos, Dimitrios Loutradis, Lina Michala
OBJECTIVE: To systematically review and appraise the existing evidence in relation to the efficacy and safety of pulsatile gonadotropin-releasing hormone (pGnRH) for the treatment of women with hypothalamic amenorrhea (HA). DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): A total of 35 studies (three randomized and 32 observational) encompassing 1,002 women with HA. INTERVENTION(S): None...
April 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29602141/is-thromboprophylaxis-cost-effective-in-ovarian-hyperstimulation-syndrome-a-systematic-review-and-cost-analysis
#19
REVIEW
Kelly Comerford Wormer, Ayesha A Jangda, Farah A El Sayed, Katherine I Stewart, Sunni L Mumford, James H Segars
BACKGROUND: The majority of serious thromboembolic events occurring in assisted reproductive technologies (ART) are in women with ovarian hyperstimulation syndrome (OHSS). OBJECTIVES: The purpose of this study was to present a thorough review and cost analysis regarding the use of venous thromboembolism (VTE) prophylaxis in OHSS to inform clinical management. DATA SOURCES: Databases used were Pubmed and Embase, in addition to checking reference lists of retrieved articles (inception to November 2017)...
May 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29587552/work-disability-negotiations-supervisors-view-of-work-disability-and-collaboration-with-occupational-health-services
#20
Liisa Lappalainen, Juha Liira, Anne Lamminpää, Tanja Rokkanen
PURPOSE: To introduce the Finnish practice of collaboration aiming to enhance work participation, to ask supervisors about its reasons and usefulness, to study supervisors' needs when they face work disability, and to compare the experiences of supervisors whose profiles differ. MATERIALS AND METHODS: An online questionnaire based on the Finnish practice of collaboration between supervisor and occupational health services (OHS) went to supervisors in six public and private organizations...
March 28, 2018: Disability and Rehabilitation
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