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Luteal phase support

Paulina A Santander Pérez, Álvaro P Ceschin, Daniela M P de Moraes, Lucileine K S N de Oliveira, Nathan I Ceschin, Nathan Ichikawa
OBJECTIVE: To analyze progesterone and prolactin plasma levels nine days after oocyte retrieval and evaluate their correlation with pregnancy rates in in vitro fertilization cycles. To achieve pregnancy, several factors are analyzed before and during the in vitro fertilization cycle. Progesterone supplementation for adequate luteal phase support is indicated despite the presence of multiple corpus luteum in IVF stimulation cycles because of blockage caused by hypothalamic agonists and antagonists...
March 15, 2018: JBRA Assisted Reproduction
Barbara Lawrenz, Suzan Samir, Nicolas Garrido, Laura Melado, Nils Engelmann, Human M Fatemi
Ovarian stimulation in a gonadotropin-releasing hormone (GnRH) antagonist protocol with the use of GnRH agonist for final oocyte maturation is the state-of-the-art treatment in patients with an expected or known high response to avoid or at least reduce significantly the risk for development of ovarian hyperstimulation syndrome (OHSS). Due to a shortened LH surge after administration of GnRH agonist in most patients, the luteal phase will be characterized by luteolysis and luteal phase insufficiency. Maintaining a sufficient luteal phase is crucial for achievement of a pregnancy; however, the optimal approach is still under debate...
2018: Frontiers in Endocrinology
Marina Wanderley Paes Barbosa, Natália Paes Barbosa Valadares, Antônio César Paes Barbosa, Adelino Silva Amaral, José Rubens Iglesias, Carolina Oliveira Nastri, Wellington de Paula Martins, Hitomi Miura Nakagawa
OBJECTIVE: To identify, appraise, and summarize the evidence from randomized controlled trials (RCTs) comparing oral dydrogesterone to vaginal progesterone capsules for luteal-phase support (LPS) in women offered fresh or frozen embryo transfers following in vitro fertilization. METHODS: Two independent authors screened the literature for papers based on titles and abstracts, then selected the studies, extracted data, and assessed the risk of bias. Dydrogesterone and progesterone were compared based on risk ratios (RR) and the precision of the estimates was assessed through the 95% confidence interval (CI)...
February 28, 2018: JBRA Assisted Reproduction
C V Bishop, R L Stouffer, D L Takahashi, E C Mishler, M C Wilcox, O D Slayden, C A True
STUDY QUESTION: What are the impacts of elevated testosterone (T) and an obesogenic western-style diet (WSD), either independently or together, on fertility and metabolic adaptations of pregnancy in primates? SUMMARY ANSWER: Testosterone increases the time to achieve pregnancy, while a WSD reduces overall fertility, and the combination of testosterone and WSD additionally impairs glucose tolerance and causes pregnancy loss. WHAT IS KNOWN ALREADY: Both hyperandrogenemia and obesity are hallmarks of polycystic ovary syndrome, which is a leading cause of infertility among women worldwide...
February 1, 2018: Human Reproduction
Jesper Friis Petersen, Anders Nyboe Andersen, Bjarke Mirner Klein, Lisbeth Helmgaard, Joan-Carles Arce
Research has focused on optimizing luteal phase support and endometrial receptivity in ovarian stimulation cycles. In this study, serial endocrine measurements were taken in 600 patients after a gonadotrophin-releasing hormone antagonist stimulation protocol. On the day of blastocyst transfer, serum progesterone and oestradiol were similar irrespective of a subsequent positive or negative pregnancy test (median 99 ng/ml versus 103 ng/ml for progesterone, respectively) or a subsequent live birth or pregnancy loss...
January 17, 2018: Reproductive Biomedicine Online
Helene Hjelmervik, Markus Hausmann, Marco Hirnstein, Alexander R Craven, Kenneth Hugdahl, Karsten Specht
Creatine is a key regulator of brain energy homeostasis, and well-balanced creatine metabolism is central in healthy brain functioning. Still, the variability of brain creatine metabolism is largely unattended in magnetic resonance spectroscopy (MRS) research. In the human brain, marginal sex differences in creatine levels have been found in the prefrontal cortex. It is however not known to what degree these sex differences are stable or change with varying gonadal hormone levels. The current study therefore investigated creatine in the prefrontal cortex across the menstrual cycle...
January 29, 2018: NeuroImage
Sinem Sari, Betul Kozanhan, Ayse Ilksen Egilmez, Aykut Soyder, Osman Nuri Aydin, Fabrizio Galimberti, Daniel Sessler, Alparslan Turan
BACKGROUND AND OBJECTIVES: Fluctuations of female sex hormones during menstrual cycle influence pain perception. Endogenous pain inhibition is impaired in follicular phase of menstrual cycle. We tested the primary hypothesis that the women having surgery during their follicular phase have more acute pain and require higher opioids than those in the luteal phase, and secondarily we tested that women who have surgery during their follicular phase have more incisional pain at 3 month postoperatively...
January 16, 2018: Revista Brasileira de Anestesiologia
Muyun Wei, Ying Gao, Bingru Lu, Yulian Jiao, Xiaowen Liu, Bin Cui, Shengnan Hu, Linying Sun, Shaowei Mao, Jing Dong, Lei Yan, Zijiang Chen, Yueran Zhao
Defective decidualization of human endometrial stromal cells (ESCs) has recently been highlighted as an underlying cause of implantation failure. FK-506 binding protein 51 (FKBP51) has been shown to participate in the steroid hormone response and the protein kinase B (AKT) regulation process, which both are important pathways involved in decidualization. The objective of the present study was to investigate the potential effects and mechanisms of FKBP51 in the regulation of ESC decidualization. By performing immunohistochemical staining on an endometrial tissue microarray (TMA) derived from normal females, we found that FKBP51 expression was much higher in the luteal phase than in the follicular phase in ESCs...
January 23, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Rung-Chi Li, Kathleen M Buchheit, Jonathan A Bernstein
PURPOSE OF REVIEW: Progestogen hypersensitivity (PH) is a rare disorder which usually occurs in women of childbearing age with symptoms ranging from urticaria with or without angioedema, multiple organ involvement consistent with allergic anaphylaxis, to a spectrum of other non-evanescent skin eruptions. In this review, we present a clinical vignette of PH and discuss the clinical presentation and proposed pathomechanisms, diagnosis, and treatment of PH. RECENT FINDINGS: The hypersensitivity symptoms are associated with exogenous progestin exposure (e...
January 19, 2018: Current Allergy and Asthma Reports
Anne Marie Z Jukic, Allen J Wilcox, D Robert McConnaughey, Clarice R Weinberg, Anne Z Steiner
BACKGROUND: Vitamin D insufficiency is associated with subfertility and prolonged estrus cycles in animals, but humans have not been well studied. METHODS: A prospective time-to-pregnancy study, Time to Conceive (2010-2015), collected up to 4 months of daily diary data. Participants were healthy, late reproductive-aged women in North Carolina who were attempting pregnancy. We examined menstrual cycle length as a continuous variable, as well as in categories: long (35+ days) and short (≤25 days)...
January 15, 2018: Epidemiology
Dominique de Ziegler, Jean Marc Ayoubi, René Frydman, Renato Fanchin
No abstract text is available yet for this article.
January 2018: Fertility and Sterility
Shoji Kokeguchi, Naoki Hayashi, Daniela Rogoff, Shin Shimizu, Osamu Ishihara
Aim: This study evaluated the efficacy and safety of vaginal progesterone gel that was administered daily for luteal phase support as part of in vitro fertilization/embryo transfer (IVF/ET) cycles in Japanese women. Methods: This was a phase III, multicenter, open-label, single-arm trial in Japanese women undergoing IVF/ET, using the Japanese Society of Obstetrics and Gynecology 2009 registry as a historical control. The primary objective was to demonstrate the non-inferiority, with regard to the clinical pregnancy rate per ET, of vaginal progesterone gel that was administered once daily, compared with the historical standard value in IVF/ET cycles in Japan...
January 2017: Reproductive Medicine and Biology
Cecily V Bishop, Emily C Mishler, Diana L Takahashi, Taylor E Reiter, Kise R Bond, Cadence A True, Ov D Slayden, Richard L Stouffer
STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD). WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms...
January 1, 2018: Human Reproduction
Jun Gao, Fang Gu, Ben-Yu Miao, Ming-Hui Chen, Can-Quan Zhou, Yan-Wen Xu
OBJECTIVE: To analyze the influence of the start point of luteal support on clinical pregnancy rate, implantation rate, and live birth rate of in vitro fertilization and embryo transfer (IVF-ET) cycles. DESIGN: Single-center prospective randomized controlled trial. SETTING: University-affiliated IVF unit. PATIENT(S): Women ≤35 years of age with day 3 FSH levels <15 mIU/mL, who were undergoing their first IVF-ET cycles and received ovarian stimulation with the use of a GnRH agonist long protocol...
January 2018: Fertility and Sterility
Amal Yaseen Zaman, Serdar Coskun, Ahmed Abdullah Alsanie, Khalid Arab Awartani
Background: The requirement for luteal phase support (LPS) in stimulated IVF cycles is well established, however drug choice, and route of administration and duration of use are not. This report evaluates patients' preference and satisfaction by using either vaginal or intramuscular (IM) progesterone (P) supplementation for luteal phase support after in vitro fertilization and embryo transfer (IVF-ET). Methods: It is a prospective cohort study done in a reproductive and infertility unit in a tertiary care hospital from March 2013 through February 2015 for four hundred and nine patients undergoing IVF-ET...
2017: Fertility Research and Practice
Hang-Wun Raymond Li, Ying-Xing Li, Tian-Tian Li, Hongjie Fan, Ernest Hung-Yu Ng, William Shu-Biu Yeung, Pak-Chung Ho, Kai-Fai Lee
STUDY QUESTION: Do both ulipristal acetate (UPA) and mifepristone inhibit embryo-endometrial attachment at concentrations corresponding to the emergency contraception (EC) dose? SUMMARY ANSWER: Both UPA and mifepristone at concentrations corresponding to the EC dose do not have an inhibitory effect on embryo implantation, although mifepristone at a higher concentration appeared to have such an effect. WHAT IS KNOWN ALREADY: Levonorgestrel is commonly used for EC, but it only acts through inhibition of ovulation...
December 1, 2017: Human Reproduction
George T Lainas, Tryfon G Lainas, Christos A Venetis, Ioannis A Sfontouris, Ioannis Z Zorzovilis, Efthymia Alexopoulou, Basil C Tarlatzis, Efstratios M Kolibianakis
OBJECTIVE: To assess ultrasound and haematological changes in ovarian hyperstimulation syndrome (OHSS) during the early luteal phase in women at high risk for developing OHSS. METHODS: This is a retrospective cohort study of 319 women undergoing in-vitro fertilisation (IVF), at high risk for OHSS following human chorionic gonadotrophin (hCG) triggering of final oocyte maturation. Patients were treated with GnRH agonist or antagonist protocol and were monitored for 5 days post oocyte retrieval...
November 6, 2017: Ultrasound in Obstetrics & Gynecology
Barbara Lawrenz, Peter Humaidan, Shahar Kol, Human M Fatemi
Final oocyte maturation using gonadotrophin-releasing hormone agonist (GnRHa) is increasingly common as it almost eliminates the risk of developing ovarian hyperstimulation syndrome (OHSS) in high-responder patients. The first studies using this approach showed a poor reproductive outcome when only vaginal progesterone was used as luteal phase support, due to the luteolysis that will develop as a result of LH withdrawal. Timely luteal administration of human chorionic gonadotrophin (HCG) will counterbalance the low LH concentrations and therefore maintain progesterone production from the corpora lutea, however, some patients with a high number of follicles will develop OHSS using this approach...
October 14, 2017: Reproductive Biomedicine Online
B Lawrenz, S Samir, L Melado, F Ruiz, H M Fatemi
In the past years, individualization of assisted reproductive technique (ART)-treatment is increasingly common to customize the treatment protocol to the patient's specific conditions. The use of GnRH-agonist for final oocyte maturation in a gonadotropin-releasing hormone (GnRH)-antagonist protocol is the best approach to reduce the risk for ovarian hyperstimulation in high responder patients. However, due to severe luteolysis, the reproductive outcome with this approach in combination with the use of vaginal progesterone as luteal phase support, was poor...
October 16, 2017: Gynecological Endocrinology
Jay L Lieberman, Mary Jane De Souza, David A Wagstaff, Nancy I Williams
INTRODUCTION: Chronic reductions in energy availability (EA) suppress reproductive function. A particular calculation of EA quantifies the dietary energy remaining after exercise for all physiological functions. Reductions in LH pulse frequency have been demonstrated when EA using this calculation is < 30 kcal/ kg ffm·d. PURPOSE: We determined whether menstrual disturbances (MD) are induced when EA is < 30 kcal/ kg ffm·d. METHODS: Thirty-five sedentary, ovulatory women 18-24 yr (weight= 59...
October 10, 2017: Medicine and Science in Sports and Exercise
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