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Luteal phase support

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https://www.readbyqxmd.com/read/27865788/testosterone-and-immune-reproductive-tradeoffs-in-healthy-women
#1
Tierney K Lorenz, Julia R Heiman, Gregory E Demas
Although testosterone (T) has been characterized as universally immunosuppressive across species and sexes, recent ecoimmunology research suggests that T's immunomodulatory effects (enhancing/suppressing) depend on the organism's reproductive context. Very little is known about the immune effects of T in healthy females, and even less about how reproductive effort modulates the immune effects of T in humans. We investigated how the interaction between endogenous T and sexual activity predicted menstrual cycle-related changes in several measures of immunity: inflammation (indexed by interleukin-6, IL-6), adaptive immunity (indexed by immunoglobulin A, IgA), and functional immunity (indexed by bactericidal assay)...
November 17, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27856803/tubal-patency-during-the-menstrual-cycle-and-during-treatment-with-hormonal-contraceptives-a-pilot-study-in-women
#2
Jeffrey T Jensen, Eva Patil, Jacqueline Seguin, Amy Thurmond
BACKGROUND: Hysterosalpingram (HSG) evaluation of tubal patency is typically performed in the follicular phase, but data to support this timing are lacking. PURPOSE: To determine whether menstrual cycle phase or hormonal treatments affect observation of tubal patency during HSG. MATERIAL AND METHODS: Ten participants underwent repeated HSG examinations: during the follicular and luteal phase of a natural menstrual cycle; 30 days following continuous administration of a combined oral contraceptive (COC); and 30 days after an intramuscular injection of depo medroxyprogesterone (DMPA) acetate...
November 17, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27825533/no-need-for-luteal-phase-support-in-ivf-cycles-after-mild-stimulation-proof-of-concept-study
#3
Anna Pia Ferraretti, Paul Devroey, M Cristina Magli, Luca Gianaroli
This is a pilot study performed in a private IVF unit. The objective of the study was to investigate whether luteal support is required in IVF cycles after mild stimulation with clomiphene citrate and low FSH doses. The study included 15 patients with good prognosis (defined as ≤38 years old with normal ovarian reserve and normovulatory cycles, body mass index <29 kg/m(2), no previous cycles, no severe endometriosis, no history of recurrent miscarriage, no endocrine/autoimmune diseases and no surgical semen extraction from the partner) undergoing IVF with mild stimulation...
October 18, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27806512/investigation-of-premenstrual-syndrome-among-the-students-of-medical-sciences
#4
Ameneh Safarzadeh, Gholamreza Ghoreishinia, Marzieh Rakhshkhorshid, Sadegh Zare, Saeedeh Rigi Yousefabadi
INTRODUCTION: Premenstrual syndrome (PMS) is the advent of physical and psychological symptoms related to the menstrual cycle, the symptoms of this syndrome start in luteal phase and ends at the end of menstrual period. During the last decades, the patterns of PMS (PMS) have studied in a wide range. But those researches had had different methodologies and definitions and the results were not well comparable. Hence, the researchers decided to conduct a study with the aim of investigation of the prevalent of PMS among the students of the Zahedan University of Medical Sciences...
July 21, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27803582/impact-of-gonadotropin-releasing-hormone-antagonist-addition-on-pregnancy-rates-in-gonadotropin-stimulated-intrauterine-insemination-cycles
#5
Shikha Jain, Abha Majumdar
OBJECTIVES: The objective of the study is to evaluate the efficacy of gonadotropin-releasing hormone (GnRH) antagonist in improving clinical pregnancy rate in gonadotropin-stimulated intrauterine insemination (IUI) cycles in patients of unexplained infertility. STUDY DESIGN: This was a prospective, randomized case-controlled study. SETTINGS: The study was conducted in the infertility clinic of a tertiary care center. MATERIALS AND METHODS: Four hundred twenty-seven women undergoing IUI following controlled ovarian stimulation with gonadotropins (recombinant follicle-stimulating hormone [r-FSH] 75 IU/day) were randomly divided into two groups...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27798046/frozen-thawed-embryo-transfers-in-natural-cycles-with-spontaneous-or-induced-ovulation-the-search-for-the-best-protocol-continues
#6
M Montagut, S Santos-Ribeiro, M De Vos, N P Polyzos, P Drakopoulos, S Mackens, A van de Vijver, L van Landuyt, G Verheyen, H Tournaye, C Blockeel
STUDY QUESTION: Is natural cycle frozen-thawed embryo transfer (NC-FET) associated with better clinical pregnancy rates (CPR) when compared to modified natural cycle frozen-thawed embryo transfer (mNC-FET)? SUMMARY ANSWER: NC-FET is associated with a higher CPR compared to mNC-FET. WHAT IS KNOWN ALREADY: There is conflicting evidence regarding the impact of hCG triggering on clinical outcomes after frozen-thawed embryo transfer (FET), and information on the effect of luteal phase support (LPS) is lacking...
October 25, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27761732/comparison-of-four-protocols-for-luteal-phase-support-in-frozen-thawed-embryo-transfer-cycles-a-randomized-clinical-trial
#7
Afsoon Zarei, Parastoo Sohail, Mohammad Ebrahim Parsanezhad, Saeed Alborzi, Alamtaj Samsami, Maryam Azizi
PURPOSE: To compare the pregnancy outcomes between four regimens of luteal phase support (LPS), including vaginal progesterone, oral dydrogesterone, combination of oral dydrogesterone and gonadotropin releasing hormone analog (GnRH-α), and combination of oral dydrogesterone and human chorionic gonadotrophin (hCG), in Frozen-thawed Embryo Transfer (FET) cycles. METHODS: This randomized clinical trial was performed during a 6-month period, including candidates for FET...
October 19, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27738657/gnrh-agonist-trigger-versus-hcg-trigger-in-gnrh-antagonist-in-ivf-icsi-cycles-a-review-article
#8
Ashraf Alyasin, Shayesteh Mehdinejadiani, Marzieh Ghasemi
Routinely, a bolus of 5.000-10.000 IU human chorionic gonadotropin (hCG) is used for the final follicular maturation and ovulation as a standard method. HCG has the same effect of luteinizing hormone (LH) with long half-life. It has the long lutheotrophic effect which increases the risk of ovarian hyper stimulation syndrome (OHSS). Recently, gonadotropin-releasing hormone agonist (GnRH-a) trigger has been used for the induction of final follicular maturation and ovulation with the aim of reducing the OHSS risk...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27738654/pregnancy-predictors-after-intrauterine-insemination-in-cases-of-unexplained-infertility-a-prospective-study
#9
Ishita Ganguly, Aparna Singh, Shilpa Bhandari, Pallavi Agrawal, Nitika Gupta
Introduction. Aim of the study was to find the effect of various prognostic factors in cases of unexplained infertility undergoing controlled ovarian stimulation (COS) with intrauterine insemination (IUI). Methods. 146 cases of unexplained infertility were included. A maximum of 3 cycles of IUI were done with clomiphene citrate/HMG. Ovulation trigger was given when the largest follicle diameter was >18 mm, and IUI was planned 36 hours later. Luteal phase support was given for 15 days, urine pregnancy test was done on day 15, ultrasonography was done at 7 weeks, and pregnancy was followed up till delivery...
2016: International Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27662646/progesterone-in-normal-and-pathological-pregnancy
#10
Gian Carlo Di Renzo, Irene Giardina, Graziano Clerici, Eleonora Brillo, Sandro Gerli
Progesterone is an essential hormone in the process of reproduction. It is involved in the menstrual cycle, implantation and is essential for pregnancy maintenance. It has been proposed and extensively used in the treatment of different gynecological pathologies as well as in assisted reproductive technologies and in the maintenance of pregnancy. Called "the pregnancy hormone", natural progesterone is essential before pregnancy and has a crucial role in its maintenance based on different mechanisms such as: modulation of maternal immune response and suppression of inflammatory response (the presence of progesterone and its interaction with progesterone receptors at the decidua level appears to play a major role in the maternal defense strategy), reduction of uterine contractility (adequate progesterone concentrations in myometrium are able to counteract prostaglandin stimulatory activity as well as oxytocin), improvement of utero-placental circulation and luteal phase support (it has been demonstrated that progesterone may promote the invasion of extravillous trophoblasts to the decidua by inhibiting apoptosis of extravillous trophoblasts)...
July 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27662416/gnrh-agonist-trigger-with-intensive-luteal-phase-support-vs-human-chorionic-gonadotropin-trigger-in-high-responders-an-observational-study-reporting-pregnancy-outcomes-and-incidence-of-ovarian-hyperstimulation-syndrome
#11
Georgios Christopoulos, Antonios Vlismas, Anna Carby, Stuart Lavery, Geoffrey Trew
A retrospective, cohort study of high-risk patients undergoing IVF treatment was performed to assess if there is a difference in clinical pregnancy rate, live birth rate and the incidence of ovarian hyperstimulation syndrome, when a GnRH agonist (GnRHa) trigger with intensive luteal support is compared to human chorionic gonadotropin (hCG) with standard luteal support. The control group consisted of 382 high-risk patients having a GnRH antagonist protocol with 194 receiving an hCG trigger. All patients had ≥18 follicles ≥11mm or serum oestradiol >18,000pmol/l on the day of trigger...
September 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27641676/progesterone-estrogen-and-androgen-receptors-in-the-corpus-luteum-of-the-domestic-cat-iberian-lynx-lynx-pardinus-and-eurasian-lynx-lynx-lynx
#12
Olga Amelkina, Lina Zschockelt, Johanna Painer, Rodrigo Serra, Francisco Villaespesa, Eberhard Krause, Katarina Jewgenow, Beate C Braun
In contrast to the species studied, the corpus luteum (CL) of Iberian and Eurasian lynx physiologically persists in the ovary for more than 2 years and continues to secrete progesterone. Such persistent CL (perCL) transition into the next cycle and are present in the ovary together with the freshly formed CL (frCL) of a new ovulation. To date, the mechanisms supporting such CL persistence are not known. We analyzed the potential receptivity of feline CL to sex steroids through mRNA measurements of progesterone receptor (PGR), progesterone receptor membrane components (PGRMC) 1 and 2, estrogen receptor (ESR) 1 and ESR2, G protein-coupled estrogen receptor 1 (GPER1), and androgen receptor (AR)...
July 5, 2016: Theriogenology
https://www.readbyqxmd.com/read/27617751/women-with-premenstrual-dysphoria-lack-the-seemingly-normal-premenstrual-right-sided-relative-dominance-of-5-htp-derived-serotonergic-activity-in-the-dorsolateral-prefrontal-cortices-a-possible-cause-of-disabling-mood-symptoms
#13
Olle Eriksson, Anders Wall, Ulf Olsson, Ina Marteinsdottir, Maria Holstad, Hans Ågren, Per Hartvig, Bengt Långström, Tord Naessén
STUDY OBJECTIVE: To investigate potential quantitative and qualitative differences in brain serotonergic activity between women with Premenstrual Dysphoria (PMD) and asymptomatic controls. BACKGROUND: Serotonin-augmenting drugs alleviate premenstrual mood symptoms in the majority of women with PMD while serotonin-depleting diets worsen PMD symptoms, both indicating intrinsic differences in brain serotonergic activity in women with PMD compared to asymptomatic women...
2016: PloS One
https://www.readbyqxmd.com/read/27565253/impact-of-luteal-phase-support-with-vaginal-progesterone-on-the-clinical-pregnancy-rate-in-intrauterine-insemination-cycles-stimulated-with-gonadotropins-a-randomized-multicenter-study
#14
Karen Peeraer, Thomas D'Hooghe, Pascale Laurent, Sofie Pelckmans, Annick Delvigne, Annouschka Laenen, M Welkenhuysen, Christine Wyns, Diane De Neubourg
OBJECTIVE: To evaluate the effect of luteal phase support (LPS) in intrauterine insemination (IUI) cycles stimulated with gonadotropins. DESIGN: Randomized multicenter trial. SETTING: Academic tertiary care centers and affiliated secondary care centers. PATIENT(S): Three hundred and ninety-three normo-ovulatory patients, <43 years, with body mass index ≤30 kg/m(2), in their first IUI cycle, with at least one patent tube, a normal uterine cavity, and a male partner with total motile sperm count ≥5 million after capacitation...
August 23, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27520293/effects-of-periovulatory-gonadotrophin-treatment-on-luteal-function-and-endometrial-expression-of-selected-genes-in-cyclic-pony-mares
#15
Martin Köhne, Natascha Ille, Regina Erber, Mahsa S Adib Razavi, Ingrid Walter, Christine Aurich
Progestin concentration in plasma during the early luteal phase is crucial for endometrial function and conceptus development. We hypothesized that periovulatory gonadotrophin treatment via support of luteal function affects endometrial gene expression in horses. Effect of age was analyzed as well. Shetland mares (n = 8, age 4-25 years) were assigned to the following treatments during five consecutive cycles in alternating order following a cross-over design: treatment hCG/-: preovulatory injection of hCG, but no gonadotrophin injection at detection of ovulation, treatment -/hCG: no preovulatory gonadodrophin injection, but injection of hCG at detection of ovulation, treatment eCG/-: preovulatory injection of eCG, but no gonadotrophin injection at detection of ovulation, treatment -/eCG: no preovulatory gonadotrophin injection, but injection of eCG at detection of ovulation, treatment control: no treatment...
July 15, 2016: Theriogenology
https://www.readbyqxmd.com/read/27448021/micro-dose-hcg-as-luteal-phase-support-without-exogenous-progesterone-administration-mathematical-modelling-of-the-hcg-concentration-in-circulation-and-initial-clinical-experience
#16
C Yding Andersen, R Fischer, V Giorgione, Thomas W Kelsey
For the last two decades, exogenous progesterone administration has been used as luteal phase support (LPS) in connection with controlled ovarian stimulation combined with use of the human chorionic gonadotropin (hCG) trigger for the final maturation of follicles. The introduction of the GnRHa trigger to induce ovulation showed that exogenous progesterone administration without hCG supplementation was insufficient to obtain satisfactory pregnancy rates. This has prompted development of alternative strategies for LPS...
October 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27434094/luteal-phase-support-with-estradiol-and-progesterone-versus-progesterone-alone-in-gnrh-antagonist-icsi-cycles-a-randomized-controlled-study
#17
Wael A Ismail Madkour, Bassel Noah, Amr M S Abdel Hamid, Hena Zaheer, Awatif Al-Bahr, Mahmoud Shaeer, Ashraf Moawad
In vitro fertilization (IVF) cycles are associated with a defective luteal phase. Although progesterone supplementation to treat this problem is standard practice, estrogen addition is debatable. Our aim was to compare pregnancy outcomes in 220 patients undergoing antagonist intracytoplasmic sperm injection (ICSI) cycles protocol. The patients were randomly assigned into two equal groups to receive either vaginal progesterone alone (90 mg once daily) starting on the day of oocyte retrieval for up to 12 weeks if pregnancy occurred or estradiol addition (2 mg twice daily) starting on the same day and continuing up to seven weeks (foetal viability scan)...
June 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27385728/id2-mediates-the-transforming-growth-factor-%C3%AE-1-induced-warburg-like-effect-seen-in-the-peritoneum-of-women-with-endometriosis
#18
Vicky J Young, Syed F Ahmad, Jeremy K Brown, W Colin Duncan, Andrew W Horne
STUDY QUESTION: Is inhibitor of DNA-binding protein 2 (ID2) a mediator of the transforming growth factor (TGF)-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis? SUMMARY ANSWER: The TGF-β1-induced changes in the metabolic phenotype of peritoneal mesothelial cells from women with endometriosis are mediated through the ID2 pathway. WHAT IS KNOWN ALREADY: TGF-β1 induces the metabolic conversion of glucose to lactate via aerobic glycolysis (the 'Warburg effect') in the peritoneum of women with endometriosis, through increased expression of the transcription factor hypoxia inducible factor α (HIF-1α)...
September 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27356792/-study-of-the-effects-of-three-luteal-phase-supporting-strategies-on-clinical-outcomes-of-intrauterine-insemination
#19
H B Chi, L L Xin, R Li, L X Chen, N N Li
OBJECTIVE: To explore the effects of three luteal phase supporting strategies on clinical outcomes of intrauterine insemination (IUI). METHODS: 1 779 subjects who underwent IUI at the Center of Reproductive Medicine, Peking University Third Hospital from November 2014 to June 2015 were enrolled in this retrospectively study.According to the luteal phase supporting strategies, all the subjects were divided into three groups: subjects receiving Dydrogesterone were group A; subjects receiving oral micronized progesterone were group B; subjects receiving vaginal micronized progesterone were group C...
June 21, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27348542/effect-of-mid-luteal-phase-gnrh-agonist-on-frozen-thawed-embryo-transfers-during-natural-menstrual-cycles-a-randomised-clinical-pilot-study
#20
Jaana Seikkula, Leena Anttila, Päivi Polo-Kantola, Risto Bloigu, Janne Engblom, Helena Tinkanen, Varpu Jokimaa
This prospective randomised crossover study evaluated the effect of mid-luteal single-dose gonadotropin-releasing hormone agonist (triptoreline) on pregnancy outcomes in natural-cycle frozen embryo transfers (FETs). Ninety-eight women were randomised to receive either standard luteal support with vaginal micronised progesterone or an additional single dose of 0.1 mg triptoreline at the time of implantation. The intervention group was composed of 65 FET cycles and the control group of 62 cycles. In the intervention group, there were more positive pregnancy tests, clinical pregnancies and live births, but the differences did not reach statistical significance...
June 27, 2016: Gynecological Endocrinology
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