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https://www.readbyqxmd.com/read/28647445/the-value-of-anti-m%C3%A3-llerian-hormone-in-predicting-clinical-pregnancy-after-intrauterine-insemination
#1
Yelena Dondik, Nassim Virji, Thomas S Butler, Jeremy T Gaskins, Kelly Pagidas, Linda Sung
OBJECTIVES: To evaluate the utility of anti-Müllerian hormone (AMH) in predicting clinical pregnancy with intrauterine insemination (IUI) and compare it to other markers of quantitative ovarian reserve. METHODS: Retrospective cohort study of women undergoing natural and stimulated IUI cycles. All patients achieved a clinical pregnancy within three IUI cycles or completed three IUI cycles without pregnancy. Receiver operating curves were generated to determine the ability of AMH, antral follicle count, age, BMI, and day 3 FSH to predict clinical pregnancy with IUI...
June 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28646941/postwash-total-motile-sperm-count-should-it-be-included-as-a-standard-male-infertility-work-up
#2
Khaled Madbouly, Ahmed Isa, Mohamad Habous, Raed Almannie, Basim Abu-Rafea, Saleh Binsaleh
INTRODUCTION: Pregnancy rates after intrauterine insemination (IUI) varies greatly. We aimed to identify pre and post processing semen analysis parameters that may be predictive of successful pregnancy in couples undergoing IUI. MATERIALS AND METHODS: A retrospective study of the records of all couples underwent IUI for a 2 year period at our infertility center. Different characteristics of female subjects, pre and post processing semen parameters and treatment parameters were compared statistically...
June 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28625022/ethical-moral-and-theological-insights-into-advances-in-male-pediatric-and-adolescent-fertility-preservation
#3
REVIEW
J J Ramstein, J Halpern, A J Gadzinski, R E Brannigan, J F Smith
The successful treatment of boys with cancer has led to increasing attention to preserving their quality of life after completing cancer therapy. One of the top priorities for living a full life is keeping open the opportunity to have children. While sperm banking for males facing sterilizing cancer treatment can be effective, this approach requires subsequent use of reproductive procedures such as in vitro fertilization (IVF) or intrauterine insemination (IUI) to achieve a pregnancy. Advances in fertility preservation techniques may allow pre-pubertal boys to conceive using advanced stem cell technologies and stem cell transplantation in the future...
June 18, 2017: Andrology
https://www.readbyqxmd.com/read/28612975/the-effect-of-endometrial-scratch-injury-on-pregnancy-outcome-in-women-with-previous-intrauterine-insemination-failure-a-randomized-clinical-trial
#4
Mahnaz Ashrafi, Ensieh Shahrokh Tehraninejad, Mansooreh Haghiri, Masoumeh Masomi, Shahideh Jahanian Sadatmahalleh, Arezoo Arabipoor
AIM: Endometrial scratch injury (ESI) has been recently proposed to enhance the implantation rate in assisted reproductive technology cycles. The present study was conducted to determine the effect of ESI on pregnancy rate in women with intrauterine insemination (IUI) failure. METHODS: This prospective randomized controlled study was carried out in Imam-Khomeini Hospital and Royan Institute, Tehran, during a 12-month period from January 2013 to January 2014. After assessment, 169 patients who had IUI failure twice or more (no chemical or clinical pregnancy) with normal uterine anatomy and hysterosalpingography, were enrolled...
June 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28605667/single-versus-double-intrauterine-insemination-iui-for-pregnancy-a-systematic-review-and-meta-analysis
#5
REVIEW
Morteza Arab-Zozani, Carolina O Nastri
This study is focused in appraising the current evidence comparing double and single IUI for achieving a pregnancy. The primary outcomes were live birth and ectopic pregnancy per women randomized. Secondary outcomes included clinical pregnancy and miscarriage. The evaluation of the risk of bias within each study was structured using the Cochrane risk of bias and the overall quality of the body of evidence was assessed through the GRADE criteria. Electronic searches were run in 4 databases and resulted in 15 studies included encompassing 3795 women...
May 26, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28598138/unexplained-infertility-live-birth-s-prognostic-factors-to-determine-the-art-management
#6
Alexandra Ohannessian, Anderson Loundou, Audrey Gnisci, Odile Paulmyer-Lacroix, Jeanne Perrin, Blandine Courbiere
BACKGROUND: The purpose of this retrospective observational study was to identify prognostic factors that lead to a live birth (LB) in couples with unexplained infertility in order to define the best ART strategy. METHODS: Prognostic factors of couples with unexplained infertility managed initially with gonadotropin intrauterine inseminations (IUI) at a single university fertility center were analyzed. Infertility was not considered "unexplained" in case of mild male infertility and suspicion of diminished ovarian reserve (FSH>10IU/L)...
June 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28591847/implementing-targeted-expectant-management-in-fertility-care-using-prognostic-modelling-a-cluster-randomized-trial-with-a-multifaceted-strategy
#7
F A M Kersten, W L D M Nelen, N M van den Boogaard, M M van Rumste, C A Koks, J IntHout, H R Verhoeve, M J Pelinck, D E S Boks, J Gianotten, F J M Broekmans, M Goddijn, D D M Braat, B W J Mol, R P G M Hermens
STUDY QUESTION: What is the effectiveness of a multifaceted implementation strategy compared to usual care on improving the adherence to guideline recommendations on expectant management for couples with unexplained infertility? SUMMARY ANSWER: The multifaceted implementation strategy did not significantly increase adherence to guideline recommendations on expectant management compared to care as usual. WHAT IS KNOWN ALREADY: Intrauterine insemination (IUI) with or without ovarian hyperstimulation has no beneficial effect compared to no treatment for 6 months after the fertility work-up for couples with unexplained infertility and a good prognosis of natural conception...
June 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28588634/in-silico-identification-of-epitopes-from-house-cat-and-dog-proteins-as-peptide-immunotherapy-candidates-based-on-human-leukocyte-antigen-binding-affinity
#8
H N Tipu, D Ahmed, S A H Gardezi
The objective of this descriptive study was to determine Felis domesticus (cat) and Canis familiaris (dog) protein epitopes that bind strongly to selected HLA class II alleles to identify synthetic vaccine candidate epitopes and to identify individuals/populations who are likely to respond to vaccines. FASTA amino acid sequences of experimentally validated allergenic proteins of house cat and dog were identified using International Union of Immunological Societies (IUIS) allergen nomenclature database. NetMHCII 2...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/28551840/pregnancy-after-endometrial-scratching-in-infertile-couples-undergoing-ovulation-induction-and-intrauterine-insemination-cycles-a-randomized-controlled-trial
#9
Tuhina Goel, Reeta Mahey, Neerja Bhatla, Mani Kalaivani, Sangeeta Pant, Alka Kriplani
PURPOSE: To study the effect of endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination (IUI) cycles. METHODS: A prospective randomized controlled trial was conducted in the Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India. One hundred forty-four women with primary/secondary infertility were recruited. Couples were either unexplained or male factor infertility. Subjects were randomized into intervention (scratching) and control group...
May 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28550023/the-super-study-protocol-for-a-randomised-controlled-trial-comparing-follicle-stimulating-hormone-and-clomiphene-citrate-for-ovarian-stimulation-in-intrauterine-insemination
#10
N A Danhof, M van Wely, Cam Koks, J Gianotten, J P de Bruin, B J Cohlen, D P van der Ham, N F Klijn, Mha van Hooff, Fjm Broekmans, K Fleischer, Cah Janssen, J M Rijn van Weert, J van Disseldorp, M Twisk, M Traas, Mfg Verberg, M J Pelinck, J Visser, Dam Perquin, DES Boks, H R Verhoeve, C F van Heteren, Bwj Mol, S Repping, F van der Veen, M H Mochtar
OBJECTIVE: To study the effectiveness of four cycles of intrauterine insemination (IUI) with ovarian stimulation (OS) by follicle-stimulating hormone (FSH) or by clomiphene citrate (CC), and adherence to strict cancellation criteria. SETTING: Randomised controlled trial among 22 secondary and tertiary fertility clinics in the Netherlands. PARTICIPANTS: 732 women from couples diagnosed with unexplained or mild male subfertility and an unfavourable prognosis according to the model of Hunault of natural conception...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28530327/-clinical-aspects-of-intrauterine-insemination
#11
REVIEW
Eliezer Girsh, Semion Meltzer, Buzhena Saar-Ryss, Gad Liberty, Jaakov Rabinson, Shevach Friedler
Intrauterine insemination (IUI) is an intervention performed frequently in the treatment of couples suffering from subfertility and women treated using donor sperm. The factors predicting its success include female parameters such as age and ovarian function and male parameters such as sperm quality. However, many details regarding its clinical application such as the methodology of sperm preparation, timing of IUI, the number of inseminations in the same cycle, the recommended number of cycles to be performed and the minimal threshold values of the sperm sample profile required are controversial...
August 2016: Harefuah
https://www.readbyqxmd.com/read/28501361/intrauterine-insemination-with-gonadotropin-stimulation-or-in%C3%A2-vitro-fertilization-for-the-treatment-of-unexplained-subfertility-a-randomized-controlled-trial
#12
Anupa Nandi, Priya Bhide, Richard Hooper, Anil Gudi, Amit Shah, Khalid Khan, Roy Homburg
OBJECTIVE: To evaluate the best first line management option for the treatment of unexplained subfertility-controlled ovarian hyperstimulation (COH) with gonadotropins and IUI or IVF. DESIGN: Randomized controlled trial. SETTING: Single center trial in a tertiary referral unit. PATIENT(S): Couples with unexplained subfertility. INTERVENTION(S): Couples were randomized to receive either three cycles of IUI + COH or one cycle of IVF...
June 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28495501/semen-modulated-secretory-activity-of-oviductal-epithelial-cells-is-linked-to-cellular-proteostasis-network-remodeling-proteomic-insights-into-the-early-phase-of-interaction-in-the-oviduct-in-vivo
#13
Birgit Steinberger, Hans Yu, Theodor Brodmann, Daniela Milovanovic, Ursula Reichart, Urban Besenfelder, Konstantin Artemenko, Ebrahim Razzazi-Fazeli, Gottfried Brem, Corina Mayrhofer
The oviductal epithelium is crucial for the integrity of the female organ. Previously we got evidence that the surface proteome of oviductal epithelial cells (Oecs) is promptly altered in response to insemination and thus suggested that this early phase plays a notable regulatory role in maintaining cellular function. This study further aimed to assess the effect of semen on the cellular and molecular mechanisms in rabbit Oecs. A quantitative gel-based proteomic approach was applied to analyze changes at three time points (0h, 1h, 2h) after intrauterine insemination (IUI) compared to time matched controls...
May 8, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28472455/the-long-term-prognosis-for-live-birth-in-couples-initiating-fertility-treatments
#14
S S Malchau, A A Henningsen, A Loft, S Rasmussen, J Forman, A Nyboe Andersen, A Pinborg
STUDY QUESTION: What are the long-term chances of having a child for couples starting fertility treatments and how many conceive with ART, IUI and without treatment? SUMMARY ANSWER: Total 5-year live birthrates were strongly influenced by female age and ranged from 80% in women under 35-26% in women ≥40 years, overall, 14% of couples conceived naturally and one-third of couples starting treatments with intrauterine insemination delivered from that treatment. WHAT IS KNOWN ALREADY: Few studies report success rates in fertility treatments across a couple's complete fertility treatment history, across clinics, evaluating live births after insemination, ART and natural conceptions...
May 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28461075/rfsh-in-medically-assisted-procreation-evidence-for-ovarian-follicular-hyperplasia-and-interest-of-mass-spectrometry-to-measure-17-hydroxyprogesterone-and-%C3%AE-4-androstenedione-in-serum
#15
M C Menet, M L Hebert-Schuster, N Lahlou, L Marcellin, M C Leguy, V Gayet, J Guibourdenche
Ovarian monitoring requires the determination of serum estradiol and progesterone levels. We investigated whole follicular steroidogenesis under rFSH in medically assisted procreation (MAP: 26 IVF, 24 ICSI) compared to 11 controls (IUI). Estrone, estradiol, Δ4-androstenedione, testosterone, progesterone and 17-hydroxyprogesterone were measured by immunoassay and mass spectrometry except for estrogens. At the start of a spontaneous or induced cycle, steroids levels fluctuated within normal ranges: estradiol (314-585 pmol/L), estrone (165-379 pmol/L) testosterone (1...
April 28, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28456806/navigating-through-the-jungle-of-allergens-features-and-applications-of-allergen-databases
#16
Christian Radauer
The increasing number of available data on allergenic proteins demanded the establishment of structured, freely accessible allergen databases. In this review article, features and applications of 6 of the most widely used allergen databases are discussed. The WHO/IUIS Allergen Nomenclature Database is the official resource of allergen designations. Allergome is the most comprehensive collection of data on allergens and allergen sources. AllergenOnline is aimed at providing a peer-reviewed database of allergen sequences for prediction of allergenicity of proteins, such as those planned to be inserted into genetically modified crops...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28452247/predictive-value-of-repeated-measurements-of-luteal-progesterone-and-estradiol-levels-in-patients-with-intrauterine-insemination-and-controlled-ovarian-stimulation
#17
Panagiotis Bakas, Maria Simopoulou, Maria Giner, Petros Drakakis, Perikles Panagopoulos, Nikolaos Vlahos
OBJECTIVE: The objective of this study is to assess if the difference of repeated measurements of estradiol and progesterone during luteal phase predict the outcome of intrauterine insemination. DESIGN: Prospective study. SETTING: Reproductive clinic. PATIENTS: 126 patients with infertility. INTERVENTION(S): Patients underwent controlled ovarian stimulation with recombinant FSH (50-150 IU/d)...
April 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28439939/identification-of-a-polygalacturonase-cup-s-2-as-the-major-ccd-bearing-allergen-in-cupressus-sempervirens-pollen
#18
Y Shahali, J-P Sutra, C Hilger, K Swiontek, I Haddad, J Vinh, L Guilloux, D Charpin, H Sénéchal, P Poncet
As IgE glyco-epitopes, also referred to as cross-reactive carbohydrate determinants (CCDs), can share significant structural homologies between different plants, they are prone to extensive cross-reactivity among allergen pollen extracts. Here, cypress pollen allergens, especially a polygalacturonase (PG), were further characterized using double one-dimensional electrophoresis (D1-DE). The presence of specific IgE directed against CCDs was investigated by bromelain IgE inhibition and concanavalin A binding assays using sera of cypress pollen-sensitized patients...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28405113/a-new-dawn-for-intrauterine-insemination-efficient-and-prudent-practice-will-benefit-patients-the-fertility-industry-and-the-healthcare-bodies
#19
REVIEW
Gulam Bahadur, Roy Homburg, Ansam Al-Habib
This review addresses the misplaced facts about the IUI procedure within a lucrative fertility industry. Evidence suggests IUI must be a first-line treatment option for most couples except in cases of bilateral tubal blockage and severe oligozoospermia. We introduce the concept of using 'consecutive ejaculation' in men with subfertility and one which can radically alter the male infertility definition, thereby providing a new approach to examining and managing male factor infertility. The review also explores various aspects affecting the IUI procedure, its determinants of success, risks and areas for future improvements...
April 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28396044/predictive-factors-influencing-pregnancy-rates-after-intrauterine-insemination-with-frozen-donor-semen-a-prospective-cohort-study
#20
Annelies Thijssen, An Creemers, Wim Van der Elst, Eva Creemers, Eva Vandormael, Nathalie Dhont, Willem Ombelet
The extent to which certain parameters can influence pregnancy rates after intrauterine insemination with frozen donor semen was examined prospectively. Between July 2011 and September 2015, 402 women received 1264 IUI cycles with frozen donor semen in a tertiary referral infertility centre. A case report form was used to collect data prospectively. The primary outcome measure was clinical pregnancy rate (CPR), confirmed by detection of a gestational sac and fetal heartbeat using ultrasonography at 7-8 weeks of gestation...
March 23, 2017: Reproductive Biomedicine Online
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