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https://www.readbyqxmd.com/read/27922279/clinical-experience-with-an-ovarian-stimulation-protocol-for-intrauterine-insemination-adopting-a-gonadotropin-releasing-hormone-antagonist-at-low-dose
#1
Adalisa Ponzano, Enrica Concetta Colangelo, Lucia Di Biase, Federica Romani, Gian Mario Tiboni
Studies testing the effectiveness of GnRH antagonists in controlled ovarian stimulation (COS) for intrauterine insemination (IUI) have provided controversial results. The present study was undertaken to evaluate, whether the use of a half of the conventional dose of the GnRH antagonist cetrorelix can be effective in increasing the successful rate of IUI cycles. Patients started COS with human menopausal gonadotropin (hMG) on day three of the menstrual cycle. Cetrorelix was started when at least one follicle of ≥14 mm, was detected at the ultrasound scan, according to the flexible multiple daily dose protocol, and continued until the trigger day with recombinant hCG...
December 6, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27803588/ficoll-400-density-gradient-method-as-an-effective-sperm-preparation-technique-for-assisted-reproductive-techniques
#2
Hyacinth N Highland, A Sharma Rishika, S Shaikh Almira, P Bansal Kanthi
BACKGROUND: Infertility being a burning issue, the male itself contributes about 40% as a cause, as evident by statistical data. However, Assisted Reproductive Technology (ART) has emerged as a powerful tool in the management of infertility. Sperm preparation techniques govern the selection procedure to separate functional spermatozoa which can then be used in IUI, IVF, and ART and for cryopreservation. AIM: The present study was aimed at evaluation of sperm preparation techniques for reliability, performance and to determine the most effective, feasible and economical technique...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803582/impact-of-gonadotropin-releasing-hormone-antagonist-addition-on-pregnancy-rates-in-gonadotropin-stimulated-intrauterine-insemination-cycles
#3
Shikha Jain, Abha Majumdar
OBJECTIVES: The objective of the study is to evaluate the efficacy of gonadotropin-releasing hormone (GnRH) antagonist in improving clinical pregnancy rate in gonadotropin-stimulated intrauterine insemination (IUI) cycles in patients of unexplained infertility. STUDY DESIGN: This was a prospective, randomized case-controlled study. SETTINGS: The study was conducted in the infertility clinic of a tertiary care center. MATERIALS AND METHODS: Four hundred twenty-seven women undergoing IUI following controlled ovarian stimulation with gonadotropins (recombinant follicle-stimulating hormone [r-FSH] 75 IU/day) were randomly divided into two groups...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27766362/ultrasensitive-and-rapid-detection-of-%C3%AE-conglutin-combining-aptamers-and-isothermal-recombinase-polymerase-amplification
#4
Miriam Jauset-Rubio, Jonathan Sabaté Del Río, Teresa Mairal, Markéta Svobodová, Mohammad S El-Shahawi, Abdulaziz S Bashammakh, Abdulrahman O Alyoubi, Ciara K O'Sullivan
Lupin is increasingly being used in a variety of food products due to its nutritional, functional and nutraceutical properties. However, several examples of severe and even fatal food-associated anaphylaxis due to lupin inhalation or ingestion have been reported, resulting in the lupin subunit β-conglutin, being defined as the Lup an 1 allergen by the International Union of Immunological Societies (IUIS) in 2008. Here, we report an innovative method termed aptamer-recombinase polymerase amplification (Apta-RPA) exploiting the affinity and specificity of a DNA aptamer selected against the anaphylactic β-conglutin allergen termed β-conglutin binding aptamer II (β-CBA II), facilitating ultrasensitive detection via isothermal amplification...
October 20, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27747683/difficulty-using-smart-pump-logs-to-recreate-a-patient-safety-event-case-study-and-considerations-for-pump-enhancements
#5
Andrew A M Ibey, Derek Andrews, Barb Ferreira
The authors present a case in which a physical anomaly with an infusion pump resulted in an unforeseen fault that the nurse's attempts to resolve unknowingly exacerbated. This case study presents the first report in the literature to detail the difficulty in recreating a patient safety event using smart pump logs, support server continuous quality improvement (CQI) data, and the drug order entry system to elucidate the clinical scenario. A 75-year-old male patient presented to a major teaching hospital and was admitted to the intensive care unit (ICU) with a massive gastrointestinal bleed and myocardial infarction, then stabilized...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27738660/does-intrauterine-saline-infusion-by-intrauterine-insemination-iui-catheter-as-endometrial-injury-during-ivf-cycles-improve-pregnancy-outcomes-among-patients-with-recurrent-implantation-failure-an-rct
#6
Saghar Salehpour, Marzieh Zamaniyan, Nasrin Saharkhiz, Shahrzad Zadeh Modares, Sedighe Hosieni, Samira Seif, Narges Malih, Parinaz Rezapoor, Mohammad-Reza Sohrabi
BACKGROUND: Recurrent implantation failure is one of the most issues in IVF cycles. Some researchers found that beneficial effects of endometrial Scratching in women with recurrent implantation failure, while some authors demonstrated contrary results. OBJECTIVE: The present study aimed to investigate the effect of intrauterine. Saline infusion as a form of endometrial injury, during fresh in vitro fertilization-embryo transfer cycle, among patients with recurrent implantation failure...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27738654/pregnancy-predictors-after-intrauterine-insemination-in-cases-of-unexplained-infertility-a-prospective-study
#7
Ishita Ganguly, Aparna Singh, Shilpa Bhandari, Pallavi Agrawal, Nitika Gupta
Introduction. Aim of the study was to find the effect of various prognostic factors in cases of unexplained infertility undergoing controlled ovarian stimulation (COS) with intrauterine insemination (IUI). Methods. 146 cases of unexplained infertility were included. A maximum of 3 cycles of IUI were done with clomiphene citrate/HMG. Ovulation trigger was given when the largest follicle diameter was >18 mm, and IUI was planned 36 hours later. Luteal phase support was given for 15 days, urine pregnancy test was done on day 15, ultrasonography was done at 7 weeks, and pregnancy was followed up till delivery...
2016: International Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27729968/tadalafil-for-endometrial-growth-in-clomiphene-citrate-stimulated-cycles-in-an-iui-programma-a-pilot-study
#8
D H Mendez Lozano, M V Lenero, R L Gonzalez, J B Scheffer, M T Gonzalez, Y Barron, R Frydman
AIM OF THE STUDY: The objective of this study was to assess the impact of tadalafil on endometrial growth, the uterine artery pulsatility index (PI) and the uterine artery resistance index (RI) in patients under clomiphene ovarian stimulation for intrauterine insemination (IUI). METHODS: This randomized crossover study included 30 patients with a normal endometrium over 53 cycles, and 46 of those cycles in 23 patients were included in the analysis. In group A the patients were under 100 mg clomiphene daily for five days (2-6) and 5 mg tadalafil daily for 7 days (4-10)...
December 28, 2015: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27717929/ultrasonographic-peculiarities-of-fetoplacental-complex-in-pregnancy-complicated-by-intrauterine-infection
#9
Nicholay A Shcherbina, Liudmyla A Vygovskaya
INTRODUCTION: the relevance of intrauterine infections is determined by significant peri- and postnatal loss as well as health impairment, which often results in disability and reduced quality of life. Ultrasonography is employed in order to provide a reliable assessment of the functional state of the fetoplacental system secondary to intrauterine fetal infection in the course of pregnancy. Ultrasound imaging is essential in diagnosis of various preclinical complications of pregnancy and detection of abnormalities in the developing fetus...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27695610/assisted-reproductive-technology-in-iran-the-first-national-report-on-centers-2011
#10
Mehrandokht Abedini, Azadeh Ghaheri, Reza Omani Samani
BACKGROUND: Due to the worldwide increase in infertility, it is both necessary and important to have assisted reproductive technology (ART) registries. In Iran, donation and surrogacy programs are approved by decrees from religious scholars. ART has been used since 1984 in Iran and the first Iranian infant conceived by gamete intra-fallopian transfer (GIFT) was born in 1989. This report, however, is the first national report on Iranian ART centers. MATERIALS AND METHODS: This cross-sectional study, conducted under the supervision of the Iranian Ministry of Health, presented a summary of the numbers and percentages of centers that provided infertility services in Iran, as well as the status of ART in Iran during 2011...
October 2016: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/27686502/does-intrauterine-insemination-timing-matter-for-achieving-pregnancy-during-ovulation-induction-using-gonadotropins-a-retrospective-cohort-study
#11
Omer Hamid Yumusak, Serkan Kahyaoglu, Meryem Kuru Pekcan, Esra Isci, Mehmet Cinar, Yasemin Tasci
BACKGROUND: Intrauterine insemination (IUI) is a commonly used procedure to increase the infertile couples' chance of pregnancy. Single or double insemination and different timing choices are modifications of this intervention. The aim of this study was to elucidate the effect of the IUI procedure on clinical pregnancy rates when performed at 24 hours or 36 hours after ovulation triggered by human chorionic gonadotropin (hCG) following ovulation induction with gonadotropins. METHODS: One hundred and thirteen women diagnosed with polycystic ovarian syndrome (PCOS) (as per Rotterdam's criteria) or unexplained infertility, who were treated using gonadotropins for ovulation induction and IUI for increasing fertilization potential, were recruited from the medical records of the infertility clinic...
September 26, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27676719/outcomes-of-cryopreserved-sperm-in-case-of-spinal-cord-injury-in-lyon-france
#12
Perrine Séguin, Kathleen Charvier, Frédérique Courtois, Corinne Del Aguila, Bruno Fernandez, Gilles Rode, Jacqueline Lornage, Alain Ruffion, Sandrine Giscard d'Estaing
OBJECTIVE: Sperm cryopreservation can be offered to men with spinal cord injury, as only 10% of spinal cord injured men (SCI) can have a child without assistive reproductive technologies (ART). Very few studies are dedicated to the outcomes of these cryopreservations. Our study aims to analyze the outcomes of these cryopreservation, namely their use or not for an ART, and to evaluate the success rate in case of ART. MATERIAL/PATIENTS AND METHODS: In May 2015, we retrospectively identified all people with stable spinal cord injury sent to the CECOS (Centre d'études de la conservation des œufs et du sperme: Egg, Sperm Embryo banking) by the department of neuroperineology based in the hospital Henry Gabrielle, for the first time between 1st January 2009 and 31st December 2013, to undergo a sperm cryopreservation of spermatozoa...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27666567/utilization-of-fertility-treatment-and-reproductive-choices-by-lesbian-couples
#13
Olivia J Carpinello, Mary Casey Jacob, John Nulsen, Claudio Benadiva
OBJECTIVE: To describe intentions and outcomes of lesbian couples requesting reproductive assistance; and report number of cycles needed to achieve a live birth. DESIGN: Retrospective chart review. SETTING: University-based fertility center. PATIENT(S): A total of 306 lesbian couples who sought reproductive assistance between 2004 and 2015. INTERVENTION(S): Intrauterine insemination or IVF using donor sperm...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27664205/iui-and-ivf-for-unexplained-subfertility-where-did-we-go-wrong
#14
R I Tjon-Kon-Fat, A J Bensdorp, I Scholten, S Repping, M van Wely, B W J Mol, F van der Veen
IUI is a first-line treatment for couples with unexplained or mild male subfertility and has become one of the most widely used fertility-enhancing treatments. The results of a recent trial comparing IVF to IUI, demonstrating similar live birth rates, have been used to build a case supporting the effectiveness of IUI. Yet, this conclusion might be somewhat premature, as the superiority of neither IUI nor IVF over no treatment has ever been proven. The evidence on the effectiveness and safety of IUI and IVF has been evaluated in two Cochrane reviews which both suggested that there is insufficient evidence to conclude that IUI or IVF is effective compared to sexual intercourse in couples with unexplained subfertility...
September 22, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27651720/factors-affecting-clinical-pregnancy-rates-after-iui-for-the-treatment-of-unexplained-infertility-and-mild-male-subfertility
#15
Melahat Atasever, Müberra Namlı Kalem, Şafak Hatırnaz, Ebru Hatırnaz, Ziya Kalem, Zeynep Kalaylıoğlu
OBJECTIVE: The aim of the present retrospective study was to evaluate intrauterine insemination (IUI) clinical experiences and to define the variables for predicting success. MATERIAL AND METHODS: The present study was an observational trial performed in a private IVF center on subfertile couples who had applied for treatment between 2002 and 2012, in which the data of 503 IUI cases were retrospectively reviewed. Couples who had been diagnosed with unexplained and mild male subfertility were included...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27651655/factors-leading-to-pregnancies-in-stimulated-intrauterine-insemination-cycles-and-the-use-of-consecutive-ejaculations-within-a-small-clinic-environment
#16
Gulam Bahadur, Ofran Almossawi, Afeeza IIlahibuccus, Ansam Al-Habib, Stanley Okolo
INTRODUCTION: Understanding and improving IUI pregnancy rates has enormous global appeal and application. This pilot study goes one step further by utilising consecutive ejaculates from men with oligozoospermia and comparing with normozoospermic male group. MATERIALS AND METHODS: A retrospective analysis was performed on 117 IUI-stimulated treatment cycles in a small fertility clinic in North Middlesex University Hospitals Trust, UK, within a NHS setting. Risks of OHSS and multiple births are carefully controlled...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27651646/evaluation-of-role-of-gnrh-antagonist-in-intrauterine-insemination-iui-cycles-with-mild-ovarian-hyperstimulation-moh-a-prospective-randomised-study
#17
Leena Wadhwa, Rupali Khanna, Taru Gupta, Sangeeta Gupta, Sarika Arora, Sumi Nandwani
AIMS AND OBJECTIVE: To evaluate the role of GnRH antagonist in prevention of premature LH surge and increasing pregnancy rates in IUI cycle with mild ovarian hyperstimulation (MOH). STUDY DESIGN: Prospective parallel, randomised controlled study. MATERIAL AND METHODS: Couples diagnosed with unexplained, male factor subfertility and with one or both tubes patent were randomised to receive either a GnRH antagonist (study group) or no intervention (control group)...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27646677/improving-icsi-a-review-from-the-spermatozoon-perspective
#18
Mara Simopoulou, Laertis Gkoles, Panagiotis Bakas, Polina Giannelou, Theodoros Kalampokas, Konstantinos Pantos, Michael Koutsilieris
: Intracytoplasmic sperm injection (ICSI) is the most frequently applied method for fertilization making the process of identifying the perfect spermatozoon fundamental. Herein we offer a critical and thorough presentation on the techniques reported regarding (i) handling and preparing semen samples, (ii) identifying and 'fishing' spermatozoa, and (iii) improving key factors, such as motility for a successful ICSI practice. These approaches are suggested to make the process easier and more effective especially in atypical and challenging circumstances...
December 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27628955/in-vitro-fertilization-versus-mild-stimulation-intrauterine-insemination-in-women-aged-40-and-older
#19
Laurice Bou Nemer, Vanessa N Weitzman, Kristopher L Arheart, Marcelo J Barrionuevo, Daniel R Christie, Youssef Mouhayar, David I Hoffman, Wayne S Maxson, Steven J Ory
INTRODUCTION: The objective of this study was to compare clinical pregnancy rates (PRs) and pregnancy outcomes (POs) in patients undergoing in vitro fertilization (IVF) and a specific controlled ovarian hyperstimulation (mild-stimulation or mini-stim) and intrauterine insemination (IUI) protocol in women older than 40. METHODS: It is a retrospective chart review of 770 cycles of all women aged 40 and older who underwent a first cycle of either IVF or mini-stim IUI between the years 2007 and 2012 at a single infertility center...
September 14, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27627603/the-impact-of-ovarian-stimulation-on-the-outcome-of-intrauterine-insemination-treatment-an-analysis-of-8893-cycles
#20
Jinyong Liu, Tin-Chiu Li, Jing Wang, Wei Wang, Zhen Hou, Jiayin Liu
OBJECTIVE: To evaluate the impact of ovarian stimulation on the outcome of intrauterine insemination (IUI). DESIGN: Retrospective analysis. SETTING: A single university-based centre. POPULATION: A total of 5109 couples with 8893 cycles. METHODS: The outcome of IUI with different protocols for ovarian stimulation was examined. MAIN OUTCOME MEASURES: The live birth rate (LBR), twin pregnancy rate and ovarian hyperstimulation syndrome (OHSS)...
September 2016: BJOG: An International Journal of Obstetrics and Gynaecology
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