keyword
https://read.qxmd.com/read/38536028/insights-on-obstetric-outcomes-in-pregnant-individuals-with-marfan-syndrome-evidence-from-the-national-inpatient-sample
#1
JOURNAL ARTICLE
Saeed Baradwan, Majed S Alshahrani, Khalid Khadawardi, Maha Tulbah, Osama Alomar, Abdullah Alyousef, Ibtihal A Bukhari, Ahmed Abu-Zaid
BACKGROUND: We investigated the potential association between Marfan Syndrome (MFS) and adverse obstetric outcomes using the National Inpatient Sample (NIS) database. METHODS: We utilized the International Classification of Diseases (ICD-10) system to identify relevant codes and extracted data from the NIS database covering the period 2016-2019. Descriptive statistics and χ2 tests were employed to summarize and compare baseline characteristics. Univariate and multivariate regression analyses (adjusted for age, race, hospital region, smoking status, and alcohol misuse) were conducted to evaluate association between MFS and adverse obstetric outcomes...
March 27, 2024: Minerva obstetrics and gynecology
https://read.qxmd.com/read/38534428/probiotics-supplementation-during-pregnancy-can-they-exert-potential-beneficial-effects-against-adverse-pregnancy-outcomes-beyond-gestational-diabetes-mellitus
#2
JOURNAL ARTICLE
Efthymios Poulios, Eleni Pavlidou, Sousana K Papadopoulou, Kalliopi Rempetsioti, Athanasios Migdanis, Maria Mentzelou, Maria Chatzidimitriou, Ioannis Migdanis, Odysseas Androutsos, Constantinos Giaginis
BACKGROUND: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics' healthy effects are related with the prevention of many diseases, as well as decreasing symptom severity. Currently, the most available data concerning their potential health effects are associated with metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may exert beneficial effects against diverse adverse pregnancy outcomes...
February 28, 2024: Biology
https://read.qxmd.com/read/38533951/impact-of-an-impaired-maternal-fetal-environment-on-death-in-children-with-congenital-heart-defects-undergoing-surgery-in-denmark-from-1994-to-2018
#3
JOURNAL ARTICLE
Rasmus Kristensen, Camilla Omann, Charlotte K Ekelund, J William Gaynor, Vibeke E Hjortdal
BACKGROUND: Studies show that an impaired maternal-fetal environment (iMFE) increases the mortality risk in children with single-ventricle congenital heart defects (CHDs). We investigated the impact of an iMFE on death in children with various surgically corrected CHDs. METHODS AND RESULTS: In this nationwide register-based study, we examined the association between an iMFE (including preeclampsia, gestational hypertension, gestational diabetes, maternal smoking during pregnancy) and death in a large cohort of children with surgically corrected CHDs in Denmark (1994-2018)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533846/longitudinal-management-of-cardiovascular-risk-factors-among-postpartum-women
#4
JOURNAL ARTICLE
Rebecca Lumsden, Courtney B Page, Matthew Phelan, Sarahn Wheeler, Neha Pagidipati
Background: Pregnancy-related cardiovascular (CV) conditions, including hypertensive disorders of pregnancy (HDP) and gestational diabetes (GDM), are associated with increased long-term CV risk. Methods: This retrospective cohort study defined the prevalence of HDP and GDM within a large, academic health system in the southeast United States between 2012 and 2015 and described health care utilization and routine CV screening up to 1-year following delivery among those with pregnancy-related CV conditions. Rates of follow-up visits and blood pressure, hemoglobin A1c (HbA1c), and lipid screening in the first postpartum year were compared by provider type and pregnancy-related CV condition...
March 27, 2024: Journal of Women's Health
https://read.qxmd.com/read/38533763/serum-from-pregnant-donors-induces-human-beta-cell-proliferation
#5
JOURNAL ARTICLE
Kendra R Sylvester-Armstrong, Callie F Reeder, Andrece Powell, Matthew W Becker, D Walker Hagan, Jing Chen, Clayton E Mathews, Clive H Wasserfall, Mark A Atkinson, Robert Egerman, Edward A Phelps
Pancreatic beta cells are among the slowest replicating cells in the human body and have not been observed to increase in number except during the fetal and neonatal period, in cases of obesity, during puberty, as well as during pregnancy. Pregnancy is associated with increased beta cell mass to meet heightened insulin demands. This phenomenon raises the intriguing possibility that factors present in the serum of pregnant individuals may stimulate beta cell proliferation and offer insights into expansion of the beta cell mass for treatment and prevention of diabetes...
December 31, 2024: Islets
https://read.qxmd.com/read/38533754/the-rs2018736-fibulin-5-polymorphism-as-a-determinant-for-pelvic-organ-prolapse-a-case-control-study
#6
JOURNAL ARTICLE
Juliana B Teixeira, Maria A T Bortolini, Rebecca S P Silva, Nilce C Batista, Carolina L Costa E Silva, Kristina Allen-Brady, Rodrigo A Castro
OBJECTIVE: Fibulin-5 is a connective tissue component and may play a role in pelvic organ prolapse (POP) pathogenesis. This study aimed to verify the association of the rs2018736 polymorphism of the fibulin-5 gene with POP in postmenopausal Brazilian women, and to determine the risk factors for POP. METHOD: This observational, cross-sectional, case-control study assessed postmenopausal women with advanced POP (stages III and IV) and control women (stages 0 and I) by examination and peripheral blood sample collection...
March 27, 2024: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/38533283/insulin-sensitivity-islet-cell-function-and-incretin-axis-in-pregnant-women-with-and-without-gestational-diabetes-mellitus
#7
JOURNAL ARTICLE
Niya Narayanan, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Haritha Sagili, Bobby Zachariah, Dukhabandhu Naik, Ayan Roy, Chandhana Merugu
INTRODUCTION: The aim of this study was to compare insulin sensitivity, islet cell function, and incretin axes in pregnant subjects with GDM and normal healthy controls. METHODS: Pregnant women at 24 to 28 weeks of gestation were subjected to a 75 g oral glucose tolerance test (OGTT). Samples for glucose, insulin, glucagon, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) were collected at 0, 30, 60, and 120 min during the OGTT...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532976/retinol-binding-protein-4-rbp4-circulating-levels-and-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#8
Bianca M Leca, Chris Kite, Lukasz Lagojda, Allan Davasgaium, Alex Dallaway, Kamaljit Kaur Chatha, Harpal S Randeva, Ioannis Kyrou
BACKGROUND: Gestational diabetes mellitus (GDM) is a prevalent condition where diabetes is diagnosed during pregnancy, affecting both maternal and fetal outcomes. Retinol-binding protein 4 (RBP4) is a circulating adipokine which belongs to the lipocalin family and acts as a specific carrier protein that delivers retinol (vitamin A) from the liver to the peripheral tissues. Growing data indicate that circulating RBP4 levels may positively correlate with GDM. Thus, this systematic review and meta-analysis aimed to investigate the potential relationship between circulating RBP4 levels and GDM when measured at various stages of pregnancy...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38532420/recent-advances-in-endothelial-colony-forming-cells-from-the-transcriptomic-perspective
#9
REVIEW
Yaqiong Liu, Caomhán J Lyons, Christine Ayu, Timothy O'Brien
Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral artery disease. However, some barriers hinder the clinical application of ECFC therapeutics. One of the current obstacles is that ECFCs are dysfunctional due to the underlying disease states. ECFCs exhibit dysfunctional phenotypes in pathologic states, which include but are not limited to the following: premature neonates and pregnancy-related diseases, diabetes mellitus, cancers, haematological system diseases, hypoxia, pulmonary arterial hypertension, coronary artery diseases, and other vascular diseases...
March 26, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38532128/liver-chrebp-deficiency-inhibits-fructose-induced-insulin-resistance-in-pregnant-mice-and-female-offspring
#10
JOURNAL ARTICLE
Jiaqi Li, Shuang Zhang, Yuyao Sun, Jian Li, Zian Feng, Huaxin Li, Mengxue Zhang, Tengteng Yan, Jihong Han, Yajun Duan
High fructose intake during pregnancy increases insulin resistance (IR) and gestational diabetes mellitus (GDM) risk. IR during pregnancy primarily results from elevated hormone levels. We aim to determine the role of liver carbohydrate response element binding protein (ChREBP) in insulin sensitivity and lipid metabolism in pregnant mice and their offspring. Pregnant C57BL/6J wild-type mice and hepatocyte-specific ChREBP-deficient mice were fed with a high-fructose diet (HFrD) or normal chow diet (NC) pre-delivery...
March 26, 2024: EMBO Reports
https://read.qxmd.com/read/38531998/is-there-an-advantage-to-delayed-molar-implant-placement-in-those-with-chronic-apical-periodontitis
#11
JOURNAL ARTICLE
Rabab Ahmad
DESIGN: This paper is a single-centre, double-blinded, prospective randomised control trial, comparing immediate vs delayed implant placement clinically and radiographically in patients with chronic periodontitis, specifically assessing the molar region. Seventy-four patients were recruited to the study over a one-year period, all of whom returned for follow up throughout the study. STUDY SELECTION: The study adhered to the principles outlined in the Declaration of Helsinki and obtained ethical approval from the affiliated University Hospital of Qingdao...
March 26, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38531673/natural-proliferative-phase-frozen-embryo-transfer-a-new-approach-which-may-facilitate-scheduling-without-hindering-pregnancy-outcomes
#12
JOURNAL ARTICLE
Catarina Mendes Godinho, Sérgio Reis Soares, Sofia Gouveia Nunes, Juan M Mascarós Martínez, Samuel Santos-Ribeiro
STUDY QUESTION: How does a natural proliferative phase (NPP) strategy for frozen embryo transfer (FET) compare with the conventional artificial (AC) and natural (NC) endometrial preparation protocols in terms of live birth rates (LBR)? SUMMARY ANSWER: This study supports the hypothesis that, just as for NC, NPP-FET may be a superior alternative to AC in terms of LBR. WHAT IS KNOWN ALREADY: Although FETs are increasing worldwide, the optimal FET protocol is still largely controversial...
March 26, 2024: Human Reproduction
https://read.qxmd.com/read/38531591/peer-support-continuity-and-coordinated-care-between-health-professionals-are-valued-by-women-with-type-1-diabetes-in-pregnancy
#13
JOURNAL ARTICLE
Sonia Butalia, Lois Donovan
No abstract text is available yet for this article.
March 26, 2024: Evidence-based Nursing
https://read.qxmd.com/read/38531582/effectiveness-of-metformin-to-pregnant-women-with-pcos-to-reduce-spontaneous-abortion-and-gestational-diabetes-mellitus-a-protocol-for-an-overview-of-reviews
#14
JOURNAL ARTICLE
Darmaris Souza Nassif, Bianca Lúcia Januário, Bianca Antunes Sousa, Lehana Thabane, Joelcio Francisco Abbade
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a globally prevalent endocrinological disorder and has been associated with poor pregnancy outcomes, including a higher rate of gestational diabetes and miscarriage. Metformin is among the drugs investigated to improve the prognosis of pregnant women with PCOS. OBJECTIVE: To conduct an overview of systematic reviews examining the effects of metformin versus placebo or no intervention throughout pregnancy among pregnant women with a preconception PCOS diagnosis to reduce the incidence of miscarriage and gestational diabetes...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531390/factors-associated-with-maternal-morbidity-among-black-women-in-the-united-states
#15
JOURNAL ARTICLE
Catrine Ibrahim Ibrahim Sous, William Moravec, Emily A DeFranco, Elizabeth Kelly, Robert M Rossi
OBJECTIVE: Non-Hispanic Black people (NHBP) have a 3-fold higher rate of maternal mortality compared to other racial groups. Racial disparities in maternal morbidity are well described however there are substantial differences in cultural, economic, and social determinants of health among racial groups. We sought to study the, at-risk, non-Hispanic Black population as its own cohort to identify factors most associated with severe maternal morbidity (SMM). METHODS: This is a population-based retrospective case control study of all livebirths in the U...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38530824/clinical-performance-of-170-frictional-morse-taper-implants-2-years-follow-up
#16
JOURNAL ARTICLE
Lara Steiner Back, Joseane Silva, Carolina Schäffer Morsch, Margherita Tumedei, Ricardo de Souza Magini, Adriano Piatelli, Cesar Augusto Magalhães Benfatti
This study evaluated clinical survival rates of 170 Morse taper implants through clinical and mechanical parameters in different therapeutic approaches such as single crowns, fixed partial prostheses and fixed full-arch prostheses. Patients referred to the Center on Education and Research on Dental Implants from May 2017 to July 2018 with the indication for dental implants therapy, aged >18 years, without periodontal disease, recent evidence of inflammatory activity or other oral disorders, current pregnancy, uncontrolled diabetes mellitus or heavy smoking habit were included in this study...
March 26, 2024: Journal of Oral Implantology
https://read.qxmd.com/read/38529718/a-case-of-pregnancy-with-severe-polyhydramnios-related-to-long-term-use-of-lithium
#17
JOURNAL ARTICLE
Aldo Stoppa, Ester Roda, Lluïsa Garcia-Esteve, Alba Roca-Lecumberri
OBJECTIVES: Severe polyhydramnios during pregnancy may be associated with long-term lithium use and presents considerable challenges. This complication, which has been linked to induced nephrogenic diabetes insipidus (NDI), underscores the necessity for cautious management of pregnant women with bipolar disorder. This case report aims to elucidate the relationship between long-term lithium use, pregnancy, and the development of severe polyhydramnios, emphasizing the importance of diagnosing NDI in order to prevent obstetric and neonatal complications...
March 26, 2024: Bipolar Disorders
https://read.qxmd.com/read/38528861/pre-pregnancy-body-mass-index-gestational-diabetes-mellitus-and-gestational-weight-gain-individual-and-combined-effects-on-fetal-growth
#18
JOURNAL ARTICLE
Yanyu Lyu, Mingming Cui, Lingling Zhang, Guang Zheng, Hanxiao Zuo, Qingyong Xiu, Prakesh S Shah
BACKGROUND: Pre-pregnancy body mass index (BMI), gestational diabetes mellitus (GDM), and gestational weight gain (GWG) are interlinked and may play a complex role in fetal growth. We aimed to examine the relationship between pre-pregnancy BMI, GDM, GWG, and fetal growth outcomes and explore the contribution of GDM and GWG to the relationship between Pre-pregnancy obesity/overweight and large-for-gestational-age (LGA) in a prospective cohort. METHODS: We prospectively recruited women in the first trimester and having one-step GDM screened with a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation ( n  = 802)...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38528518/mendelian-randomization-analysis-reveals-causal-relationship-between-obstetric-related-diseases-and-covid-19
#19
JOURNAL ARTICLE
Yan Fang, Dajun Fang
BACKGROUND: Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes. METHODS: A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based on genome-wide association studies (GWAS) dataset...
March 25, 2024: Virology Journal
https://read.qxmd.com/read/38528508/triglyceride-glucose-index-in-early-pregnancy-predicts-the-risk-of-gestational-diabetes-a-prospective-cohort-study
#20
JOURNAL ARTICLE
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
OBJECTIVE: This study aimed to investigate the association between the triglyceride-glucose (TyG) index in early pregnancy and the development of gestational diabetes mellitus (GDM) in the second trimester. The primary objectives were to evaluate the predictive potential of the TyG index for GDM, determine the optimal threshold value of the TyG index for GDM assessment, and compare the predictive performance of the TyG index alone versus its combination with maternal age and pre-pregnancy body mass index on GDM...
March 25, 2024: Lipids in Health and Disease
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