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https://www.readbyqxmd.com/read/28306589/older-adult-kidney-function-assessment-and-rounding-creatinine-led-to-medication-dosing-error
#1
Timothy Nguyen, Yanique Foster, Shpres Cekaj
BACKGROUND/AREAS OF UNCERTAINTY: Kidney function assessment in older adults can be unreliable because of many factors, and inaccurate assessment can lead to medication dosing error. Practitioners may have adopted the method of rounding creatinine to an arbitrary number 1.0 because of change in muscle mass and age-related change. This has in fact proven to cause more harm than good, potentially leading to underdosing of many medications. DATA SOURCES: A literature search performed using PubMed with the following key words (rounding serum creatinine, rounding serum creatinine AND pharmacist or pharmacy, rounding serum creatinine AND doctor or physician or healthcare, rounding serum creatinine AND kidney function) with no restrictions (dates or any other requirement)...
March 1, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28298956/phosphorus-regulation-in-chronic-kidney-disease
#2
Wadi N Suki, Linda W Moore
Serum phosphorus levels stay relatively constant through the influence of multiple factors-such as parathyroid hormone, fibroblast growth factor 23, and vitamin D-on the kidney, bone, and digestive system. Whereas normal serum phosphorus ranges between 3 mg/dL to 4.5 mg/dL, large cross-sectional studies have shown that even people with normal kidney function are sometimes found to have levels ranging between 1.6 mg/dL and 6.2 mg/dL. While this may partially be due to diet and the factors mentioned above, total understanding of these atypical ranges of serum phosphorus remains uncertain...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28291795/experimental-chronic-kidney-disease-attenuates-ischemia-reperfusion-injury-in-an-ex-vivo-rat-lung-model
#3
Chung-Kan Peng, Kun-Lun Huang, Chou-Chin Lan, Yu-Juei Hsu, Geng-Chin Wu, Chia-Hui Peng, Chin-Pyng Wu, Khee-Siang Chan
Lung ischemia reperfusion injury (LIRI) is one of important complications following lung transplant and cardiopulmonary bypass. Although patients on hemodialysis are still excluded as lung transplant donors because of the possible effects of renal failure on the lungs, increased organ demand has led us to evaluate the influence of chronic kidney disease (CKD) on LIRI. A CKD model was induced by feeding Sprague-Dawley rats an adenine-rich (0.75%) diet for 2, 4 and 6 weeks, and an isolated rat lung in situ model was used to evaluate ischemia reperfusion (IR)-induced acute lung injury...
2017: PloS One
https://www.readbyqxmd.com/read/28287463/stirring-the-pot-can-dietary-modification-alleviate-the-burden-of-ckd
#4
REVIEW
Matthew Snelson, Rachel E Clarke, Melinda T Coughlan
Diet is one of the largest modifiable risk factors for chronic kidney disease (CKD)-related death and disability. CKD is largely a progressive disease; however, it is increasingly appreciated that hallmarks of chronic kidney disease such as albuminuria can regress over time. The factors driving albuminuria resolution remain elusive. Since albuminuria is a strong risk factor for GFR loss, modifiable lifestyle factors that lead to an improvement in albuminuria would likely reduce the burden of CKD in high-risk individuals, such as patients with diabetes...
March 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28285313/oxidative-balance-score-and-the-risk-of-end-stage-renal-disease-and-cardiovascular-disease
#5
Titilayo O Ilori, Xiao Wang, Morong Huang, Orlando M Gutierrez, K M Venkat Narayan, Michael Goodman, William McClellan, Laura Plantinga, Akinlolu O Ojo
BACKGROUND: Oxidative balance score (OBS) is a composite measure of oxidative stress-related exposures. The aim of this study was to investigate the association between OBS, end-stage renal disease (ESRD), and cardiovascular disease (CVD). METHODS: Using data from the Chronic Renal Insufficiency Cohort, we calculated the main exposure OBS by summing up 12 apriori-defined pro- and antioxidant factors obtained from the diet history questionnaire and lifestyle assessment...
March 11, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28274240/effect-of-48-week-pegylated-interferon-%C3%AE-2a-or-nucleos-t-ide-analogue-therapy-on-renal-function-in-chinese-patients-with-chronic-hepatitis-b
#6
Ye Zhang, Wei-Lu Zhang, Xiao-Wen Pang, Lin-Xu Wang, Xin Wei, Chang-Xing Huang, Xue-Fan Bai, Shuai Han, Lin-Na Liu, Jian-Qi Lian
BACKGROUND: Controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis B virus (HBV) infection. Thus, the aim of study was to analyze the changes in renal function of chronic hepatitis B (CHB) patients in response to anti-HBV therapy and the association with treatments. METHOD: We performed a retrospective observational cohort study to investigate factors associated with renal function in 249 Chinese CHB patients who were treated with pegylated interferon α-2a (PEG-IFN-α-2a) or nucleos(t)ide analogues for 48 weeks...
March 9, 2017: Virology Journal
https://www.readbyqxmd.com/read/28273960/unusual-dyslipidemia-in-patients-with-chronic-kidney-diseases
#7
Rashmi Rekha Phukan, Rohini K Goswami
INTRODUCTION: Chronic Kidney Disease (CKD) is a major and globally increasing health problem in the general population arising from a spectrum of diseases. Majority of the patients die even before reaching End Stage Renal Disease (ESRD) due to cardiovascular complications which arise due to altered lipoprotein compositions. AIM: Present study was aimed at evaluating the serum lipid profile in CKD patients and to find the pattern of its alteration in both haemodialyzed and conservatively treated CKD patients...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28248961/effects-of-different-phosphate-lowering-strategies-in-patients-with-ckd-on-laboratory-outcomes-a-systematic-review-and-nma
#8
Nigar Sekercioglu, Argie Angeliki Veroniki, Lehana Thabane, Jason W Busse, Noori Akhtar-Danesh, Alfonso Iorio, Luciane Cruz Lopes, Gordon H Guyatt
BACKGROUND: Chronic kidney disease-mineral and bone disorder (CKD-MBD), a complication of chronic kidney disease, has been linked to reduced quality and length of life. High serum phosphate levels that result from CKD-MBD require phosphate-lowering agents, also known as phosphate binders. The objective of this systematic review is to compare the effects of available phosphate binders on laboratory outcomes in patients with CKD-MBD. METHODS: Data sources included MEDLINE and EMBASE from January 1996 to April 2016, and the Cochrane Register of Controlled Trials up to April 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28248635/health-risk-assessment-of-dietary-cadmium-intake-do-current-guidelines-indicate-how-much-is-safe
#9
Soisungwan Satarug, David A Vesey, Glenda C Gobe
BACKGROUND: Cadmium (Cd), a food-chain contaminant, is a significant health hazard. The kidney is one of the primary sites of injury after chronic Cd exposure. Kidney-based risk assessment establishes the urinary Cd threshold at 5.24 μg/g creatinine, and tolerable dietary intake of Cd at 62 μg/day per 70-kg person. However, cohort studies show that dietary Cd intake below a threshold limit and that tolerable levels may increase the risk of death from cancer, cardiovascular disease, and Alzheimer's disease...
March 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28241912/end-stage-renal-disease-outcomes-among-the-kaiser-permanente-southern-california-creatinine-safety-program-creatinine-surenet-opportunities-to-reflect-and-improve
#10
John J Sim, Michael Batech, Kim N Danforth, Mark P Rutkowski, Steven J Jacobsen, Michael H Kanter
OBJECTIVES: The Kaiser Permanente Southern California (KPSC) creatinine safety program (Creatinine SureNet) identifies and outreaches to thousands of people annually who may have had a missed diagnosis for chronic kidney disease (CKD). We sought to determine the value of this outpatient program and evaluate opportunities for improvement. METHODS: Longitudinal cohort study (February 2010 through December 2015) of KPSC members captured into the creatinine safety program who were characterized using demographics, laboratory results, and different estimations of glomerular filtration rate...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28240423/nutritional-issues-with-incremental-dialysis-the-role-of-low-protein-diets
#11
Francesco Locatelli, Lucia Del Vecchio, Valeria Aicardi
A gentle start of dialysis is a welcome possibility for both patients and physicians. Incident dialysis patients often maintain residual kidney function (RKF) for a considerable period of time; the start of dialysis is often driven mainly by uremic symptoms. Recently, the combination of a low-protein diet, along with a less-frequent dialysis schedule, has regained interest as an alternative option in selected and motivated patients. In addition, there is renewed interest in a low-protein diet in patients with moderate to advanced chronic kidney disease (CKD)...
February 27, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28237532/ureteral-reconstruction-with-ileum-long-term-follow-up-of-renal-function
#12
Joshua D Roth, M Francesca Monn, Konrad M Szymanski, Richard J Bihrle, Matthew J Mellon
OBJECTIVE: To assess long-term renal preservation and surgical outcomes in patients undergoing ureteric substitution with ileum. This has been a mainstay of reconstruction options for lengthy ureteral defects. METHODS: Consecutive patients aged 18 or older undergoing ileal ureters at our institution were retrospectively reviewed (1989-June 2013). Patients with <6 months of follow-up were excluded. Demographic, surgical and renal functional outcomes were reviewed...
February 22, 2017: Urology
https://www.readbyqxmd.com/read/28235417/accuracy-of-glomerular-filtration-rate-equations-for-chronic-kidney-disease-patients-at-the-g3a-stage-a-single-center-cross-sectional-study
#13
Yanna Dou, Xiran Sun, Dong Liu, Li Zhang, Jing Xiao, Genyang Cheng, Dahai Yu, Zhanzheng Zhao
BACKGROUND: Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR) and estimated GFR (eGFR). One of the mGFR was (99m)Tc-DTPA scintigraphy method and eGFR using GFR equations were used clinically. Equations were modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Chinese adapted MDRD (C-MDRD)...
February 24, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28231583/prevalence-of-impaired-kidney-function-in-the-german-elderly-results-from-the-berlin-aging-study-ii-base-ii
#14
Maximilian König, Maik Gollasch, Ilja Demuth, Elisabeth Steinhagen-Thiessen
BACKGROUND: In aging populations with an ever-growing burden of risk factors such as obesity, diabetes, and hypertension, chronic kidney disease (CKD) is on the rise. However, little is known about its exact prevalence among elderly adults, and often albuminuria is not included in the definition of CKD. Moreover, novel equations for the estimated glomerular filtration rate (eGFR) have recently emerged, which have not been applied comprehensively to older adults. Data on CKD awareness among the elderly are sparse...
February 24, 2017: Gerontology
https://www.readbyqxmd.com/read/28225809/the-renal-consequences-of-maternal-obesity-in-offspring-are-overwhelmed-by-postnatal-high-fat-diet
#15
Sarah J Glastras, Hui Chen, Michael Tsang, Rachel Teh, Rachel T McGrath, Amgad Zaky, Jason Chen, Muh Geot Wong, Carol A Pollock, Sonia Saad
AIMS/HYPOTHESIS: Developmental programming induced by maternal obesity influences the development of chronic disease in offspring. In the present study, we aimed to determine whether maternal obesity exaggerates obesity-related kidney disease. METHODS: Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow or HFD. At postnatal Week 8, HFD-fed offspring were administered one dose streptozotocin (STZ, 100 mg/kg i...
2017: PloS One
https://www.readbyqxmd.com/read/28223818/an-evidence-based-review-on-urate-lowering-treatments-implications-for-optimal-treatment-of-chronic-hyperuricemia
#16
REVIEW
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi
Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved in the pathogenesis of different systemic disorders that affect cardiovascular and renal systems, such as hypertension, obesity, hypercholesterolemia, atherosclerosis, metabolic syndrome, chronic heart failure, and chronic kidney disease. Recent epidemiological evidence has shown an increasing trend in the prevalence of hyperuricemia and gout in the Western world: a number of population-based studies estimate a prevalence of up to 21% for hyperuricemia and 1%-4% for gout...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28215947/food-insecurity-ckd-and-subsequent-esrd-in-us-adults
#17
Tanushree Banerjee, Deidra C Crews, Donald E Wesson, Sai Dharmarajan, Rajiv Saran, Nilka Ríos Burrows, Sharon Saydah, Neil R Powe
BACKGROUND: Poor access to food among low-income adults has been recognized as a risk factor for chronic kidney disease (CKD), but there are no data for the impact of food insecurity on progression to end-stage renal disease (ESRD). We hypothesized that food insecurity would be independently associated with risk for ESRD among persons with and without earlier stages of CKD. STUDY DESIGN: Longitudinal cohort study. SETTING & PARTICIPANTS: 2,320 adults (aged ≥ 20 years) with CKD and 10,448 adults with no CKD enrolled in NHANES III (1988-1994) with household income ≤ 400% of the federal poverty level linked to the Medicare ESRD Registry for a median follow-up of 12 years...
February 15, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28211108/evaluation-of-the-quality-and-health-literacy-demand-of-online-renal-diet-information
#18
K Lambert, J Mullan, K Mansfield, A Koukomous, L Mesiti
BACKGROUND: Dietary modification is critical in the self-management of chronic kidney disease. The present study describes the accuracy, quality and health literacy demand of renal diet information for adults with kidney disease obtained from the Internet and YouTube (www.youtube.com). METHODS: A comprehensive content analysis was undertaken in April and July 2015 of 254 eligible websites and 161 YouTube videos. The accuracy of the renal diet information was evaluated by comparing the key messages with relevant evidence-based guidelines for the dietary management of people with kidney disease...
February 16, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28209636/a-randomized-crossover-trial-of-dietary-sodium-restriction-in-stage-3-4-ckd
#19
Rajiv Saran, Robin L Padilla, Brenda W Gillespie, Michael Heung, Scott L Hummel, Vimal Kumar Derebail, Bertram Pitt, Nathan W Levin, Fansan Zhu, Samer R Abbas, Li Liu, Peter Kotanko, Philip Klemmer
BACKGROUND AND OBJECTIVES: Patients with chronic kidney disease (CKD) are often volume expanded and hypertensive. Few controlled studies have assessed the effects of a sodium-restricted diet (SRD) in CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a randomized crossover trial to evaluate the effect of SRD (target <2 g sodium per day) versus usual diet on hydration status (by bioelectrical impedance spectroscopy) and blood pressure (BP) between May of 2009 and May of 2013...
March 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28196295/association-of-pre-transplant-kidney-function-with-outcomes-after-lung-transplantation
#20
Amit Banga, Manish Mohanka, Jessica Mullins, Srinivas Bollineni, Vaidehi Kaza, Fernando Torres, Bekir Tanriover
PURPOSE: There is a lack of data regarding the independent association of pre-transplant kidney function with early and late outcomes among lung transplant (LT) recipients. METHODS: We queried the UNOS database for adult patients (≥ 18 years of age) undergoing LT between 1987 and 2013. Glomerular filtration rate (GFR) was estimated using the Modification of diet in renal disease (MDRD) and the Chronic kidney disease epidemiology collaboration (CKD-EPI) equations...
February 14, 2017: Clinical Transplantation
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