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https://www.readbyqxmd.com/read/27898405/n-acetyl-cysteine-attenuated-the-deleterious-effects-of-advanced-glycation-end-products-on-the-kidney-of-non-diabetic-rats
#1
Karina Thieme, Karolline S Da Silva, Nelly T Fabre, Sergio Catanozi, Maria Beatriz Monteiro, Daniele Pereira Santos-Bezerra, Juliana Martins Costa-Pessoa, Maria Oliveira-Souza, Ubiratan F Machado, Marisa Passarelli, Maria Lucia Correa-Giannella
AIM: To assess the renal effects of chronic exposure to advanced glycation end-products (AGEs) in the absence of diabetes and the potential impact of concomitant treatment with the antioxidant N-acetyl cysteine (NAC). METHODS: Wistar rats received intraperitoneally 20 mg/kg/day of albumin modified (AlbAGE) or not (AlbC) by advanced glycation for 12 weeks and oral NAC (600mg/L; AlbAGE+NAC and AlbC+NAC, respectively). Biochemical, urinary and renal morphological analyses; carboxymethyl-lysine (CML, an AGE), CD68 (macrophage infiltration), and 4-hydroxynonenal (4-HNE, marker of oxidative stress) immunostaining; intrarenal mRNA expression of genes belonging to pathways related to AGEs (Ager, Ddost, Nfkb1), renin-angiotensin system (Agt, Ren, Ace), fibrosis (Tgfb1, Col4a1), oxidative stress (Nox4, Txnip), and apoptosis (Bax, Bcl2); and reactive oxidative species (ROS) content were performed...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27898000/patient-survival-and-costs-on-moderately-restricted-low-protein-diets-in-advanced-ckd-equivalent-survival-at-lower-costs
#2
Piccoli Giorgina Barbara, Nazha Marta, Capizzi Irene, Vigotti Federica Neve, Mongilardi Elena, Bilocati Marilisa, Avagnina Paolo, Versino Elisabetta
The indications for delaying the start of dialysis have revived interest in low-protein diets (LPDs). In this observational prospective study, we enrolled all patients with chronic kidney disease (CKD) who followed a moderately restricted LPD in 2007-2015 in a nephrology unit in Italy: 449 patients, 847 years of observation. At the start of the diet, the median glomerular filtration rate (GFR) was 20 mL/min, the median age was 70, the median Charlson Index was 7. Standardized mortality rates for the "on-diet" population were significantly lower than for patients on dialysis (United States Renal Data System (USRDS): 0...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27890838/preoperative-evaluation-of-the-renal-function-before-the-treatment-of-abdominal-aortic-aneurysms
#3
Raphael Coscas, Sandra Wagner, Eve Vilaine, Albane Sartorius, Isabelle Javerliat, Olivier Goeau-Brissonniere, Marc Coggia, Ziad Massy
OBJECTIVES: Chronic impaired renal function (IRC) constitutes a major risk factor of morbi-mortality during the treatment of an abdominal aortic aneurism (AAA). The inflammatory state due to the AAA could result in a reduction in the muscular mass and an over-estimation of the glomerular filtration rate (GFR) with the usual formulas. The objective of this study was to determine if the formulae used to evaluate the estimated GFR were adapted in patients with AAA. MATERIALS AND METHODS: Between August 2013 and November 2014, we conducted an exploratory study to evaluate the renal function before surgery for AAA in 28 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27889756/liquid-chromatography-mass-spectrometry-reveals-the-effect-of-lactobacillus-treatment-on-the-faecal-metabolite-profile-of-rats-with-chronic-renal-failure
#4
Bin Wu, Hongli Jiang, Quan He, Meng Wang, Jinhong Xue, Hua Liu, Kehui Shi, Meng Wei, Shanshan Liang, Liwen Zhang
BACKGROUND/AIM: Chronic kidney disease is accompanied by changes in the gut microbiome and by an increase in the number of gut pathogenic bacteria. The aim of this study was to investigate the difference of the faecal metabolic profiles in rats with uremia, and to determine whether the altered metabolites in the rats with uremia can be restored by Lactobacillus. METHODS: Thirty rats were randomly divided into 3 groups: sham, uremia and uremia + probiotic (UP) groups...
November 26, 2016: Nephron
https://www.readbyqxmd.com/read/27872172/urea-a-true-uremic-toxin-the-empire-strikes-back
#5
REVIEW
Wei Ling Lau, Nosratola D Vaziri
Blood levels of urea rise with progressive decline in kidney function. Older studies examining acute urea infusion suggested that urea was well-tolerated at levels 8-10× above normal values. More recent in vitro and in vivo work argue the opposite and demonstrate both direct and indirect toxicities of urea, which probably promote the premature aging phenotype that is pervasive in chronic kidney disease (CKD). Elevated urea at concentrations typically encountered in uremic patients induces disintegration of the gut epithelial barrier, leading to translocation of bacterial toxins into the bloodstream and systemic inflammation...
January 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27865566/phosphorus-additives-and-albuminuria-in-early-stages-of-ckd-a-randomized-controlled-trial
#6
Alex R Chang, Edgar R Miller, Cheryl A Anderson, Stephen P Juraschek, Melissa Moser, Karen White, Bobbie Henry, Caitlin Krekel, Susan Oh, Jeanne Charleston, Lawrence J Appel
BACKGROUND: Little is known about the effects of phosphorus additives on patients with kidney disease. STUDY DESIGN: Randomized, double-blind, crossover trial. SETTING & PARTICIPANTS: 31 adults with early stages of presumed chronic kidney disease (estimated glomerular filtration rate ≥ 45mL/min/1.73m(2); urine albumin-creatinine ratio sex-specific cutoff points: men ≥ 17mg/g, women ≥ 25mg/g). INTERVENTION: Higher versus lower phosphorus intake for 3 weeks...
November 16, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27861335/response-of-fibroblast-growth-factor-23-to-volume-interventions-in-arterial-hypertension-and-diabetic-nephropathy
#7
Jelmer K Humalda, Sarah Seiler-Muler, Arjan J Kwakernaak, Marc G Vervloet, Gerjan Navis, Danilo Fliser, Gunnar H Heine, Martin H de Borst
Fibroblast growth factor 23 (FGF-23) rises progressively in chronic kidney disease and is associated with adverse cardiovascular outcomes. FGF-23 putatively induces volume retention by upregulating the sodium-chloride cotransporter (NCC). We studied whether, conversely, interventions in volume status affect FGF-23 concentrations.We performed a post hoc analysis of 1) a prospective saline infusion study with 12 patients with arterial hypertension who received 2 L of isotonic saline over 4 hours, and 2) a randomized controlled trial with 45 diabetic nephropathy (DN) patients on background angiotensin-converting enzyme -inhibition (ACEi), who underwent 4 6-week treatment periods with add-on hydrochlorothiazide (HCT) or placebo, combined with regular sodium (RS) or low sodium (LS) diet in a cross-over design...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27834801/trimethylamine-n-oxide-the-good-the-bad-and-the-unknown
#8
REVIEW
Manuel T Velasquez, Ali Ramezani, Alotaibi Manal, Dominic S Raj
Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein-destabilizing effects of urea. Plasma level of TMAO is determined by a number of factors including diet, gut microbial flora and liver flavin monooxygenase activity. In humans, a positive correlation between elevated plasma levels of TMAO and an increased risk for major adverse cardiovascular events and death is reported...
November 8, 2016: Toxins
https://www.readbyqxmd.com/read/27829582/postprandial-hyperlipidemia-and-remnant-lipoproteins
#9
Daisaku Masuda, Shizuya Yamashita
Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activation, coagulation, thrombus formation, and macrophage foam cell formation...
November 8, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27829460/renal-function-estimation-and-cockroft-gault-formulas-for-predicting-cardiovascular-mortality-in-population-based-cardiovascular-risk-heart-failure-and-post-myocardial-infarction-cohorts-the-heart-omics-in-ageing-homage-and-the-high-risk-myocardial-infarction
#10
João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A Pfeffer, John J V McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A Staessen, Javed Butler, Roberto Latini, Serge Masson, Alexandre Mebazaa, Hans Peter Brunner-La Rocca, Christian Delles, Stephane Heymans, Naveed Sattar, J Wouter Jukema, John G Cleland, Faiez Zannad, Patrick Rossignol
BACKGROUND: Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease Study (MDRD4), and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The CKD-EPI is the most accurate eGFR estimator as compared to a "gold-standard"; however, which of the latter is the best formula to assess prognosis remains to be clarified...
November 10, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27828870/association-of-chronic-kidney-disease-with-periprocedural-myocardial-injury-after-elective-stent-implantation-a-single-center-prospective-cohort-study
#11
Helena Jerkic, Tomislav Letilovic, Mario Stipinovic, Darko Pocanic, Jasmina Catic, Mladen Knotek
Coronary artery disease (CAD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Patients with CKD who undergo percutaneous coronary intervention (PCI) may have more ischemic events than patients without CKD. The aim of our study was to determine the incidence of periprocedural myocardial injury (PMI) after elective stent implantation in patients with CKD using the Third Joint ESC/ACCF/AHA/WHF PMI definition.In a single center prospective cohort study, we enrolled 344 consecutive patients who underwent elective PCI in a period of 39 months...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27825577/efficacy-and-safety-of-febuxostat-in-73-gouty-patients-with-stage-4-5-chronic-kidney-disease-a-retrospective-study-of-10-centers
#12
Pierre-Antoine Juge, Marie-Elise Truchetet, Evangeline Pillebout, Sébastien Ottaviani, Cécile Vigneau, Clotilde Loustau, Divi Cornec, Tristan Pascart, Renaud Snanoudj, Florian Bailly, Emilie Cornec-Le Gall, Thierry Schaeverbeke, Alain Saraux, Philippe Dieudé, René-Marc Flipo, Pascal Richette, Frédéric Lioté, Thomas Bardin, Gérard Chalès, Hang-Korng Ea
OBJECTIVES: The allopurinol dose is limited in chronic kidney disease, particularly stage 4/5 chronic kidney disease. Febuxostat has a hepatic metabolism and has been approved without dose adaptation in gouty patients with stage 1-3 chronic kidney disease. We aimed to study the safety and efficacy of febuxostat for stage 4/5 chronic kidney disease. METHODS: In this retrospective study, we included patients with (1) a diagnosis of gout, (2) febuxostat treatment, (3) estimated glomerular filtration rate≤30mL/min/1...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27806940/nadph-oxidase-2-mediates-zinc-deficiency-induced-oxidative-stress-and-kidney-damage
#13
Mirandy S Li, Sherry E Adesina, Jennifer L Gooch, Robert S Hoover, Clintoria R Williams
Zn(2+) deficiency (ZnD) is comorbid with chronic kidney disease (CKD) and worsens kidney complications. Oxidative stress is implicated in the detrimental effects of ZnD. However, the sources of oxidative stress continue to be identified. Since NADPH oxidases (Nox) are the primary enzymes that contribute to renal reactive oxygen species (ROS) generation, this study's objective was to determine the role of these enzymes in ZnD-induced oxidative stress. We hypothesized that ZnD promotes Nox upregulation resulting in oxidative stress and kidney damage...
November 2, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27803315/inhibition-of-gsk-3%C3%AE-increases-trabecular-bone-volume-but-not-cortical-bone-volume-in-adenine-induced-uremic-mice-with-severe-hyperparathyroidism
#14
Narihito Tatsumoto, Masaki Arioka, Shunsuke Yamada, Fumi Takahashi-Yanaga, Masanori Tokumoto, Kazuhiko Tsuruya, Takanari Kitazono, Toshiyuki Sasaguri
Patients with chronic kidney disease (CKD) are at increased risk for bone fractures compared with the general population. Repression of the Wnt/β-catenin signaling pathway is associated with bone abnormalities. Inhibition of glycogen synthase kinase (GSK)-3β, a critical component of the Wnt/β-catenin signaling pathway, increases bone volume through accumulation of β-catenin. It remains unknown whether inhibition of GSK-3β increases bone volume in CKD The present in vivo study examined the effects of GSK-3β inhibition on bone volume in CKD mice...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27802418/high-normal-estimated-glomerular-filtration-rate-in-early-onset-preeclamptic-women-10-years-postpartum
#15
Nina D Paauw, Jaap A Joles, José T Drost, Marianne C Verhaar, Arie Franx, Gerjan Navis, Angela H E M Maas, A Titia Lely
: Women with a history of preeclampsia have a 5- to 12-fold increased risk to develop end-stage kidney disease. Previous observations in small cohorts suggest that former preeclamptic (fPE) women have subtle abnormalities in renal hemodynamics and renal function, which might predispose them to renal failure in later life. In this study, we analyzed renal function in a cross-sectional cohort consisting of former early-onset preeclamptic (fPE, n=339) and former healthy pregnant women (fHP, n=332), overall with a mean age of 39 years at 10 years postpartum...
October 31, 2016: Hypertension
https://www.readbyqxmd.com/read/27801685/dietary-protein-intake-and-chronic-kidney-disease
#16
Gang Jee Ko, Yoshitsugu Obi, Amanda R Tortorici, Kamyar Kalantar-Zadeh
PURPOSE OF REVIEW: High-protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration. This can cause damage to glomerular structure leading to or aggravating chronic kidney disease (CKD). Hence, a low-protein diet (LPD) of 0.6-0.8 g/kg/day is often recommended for the management of CKD. We reviewed the effect of protein intake on incidence and progression of CKD and the role of LPD in the CKD management. RECENT FINDINGS: Actual dietary protein consumption in CKD patients remains substantially higher than the recommendations for LPD...
January 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27798197/the-closure-of-arteriovenous-fistula-in-kidney-transplant-recipients-is-associated-with-an-acceleration-of-kidney-function-decline
#17
Laurent Weekers, Pauline Vanderweckene, Hans Pottel, Diego Castanares-Zapatero, Catherine Bonvoisin, Etienne Hamoir, Sylvie Maweja, Jean-Marie Krzesinski, Pierre Delanaye, François Jouret
BACKGROUND: The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney transplant recipients (KTRs) remains unknown. METHODS: From 2007 to 2013, we retrospectively categorized 285 KTRs into three groups: no AVF (Group 0, n = 90), closed AVF (Group 1, n = 114) and left-open AVF (Group 2, n = 81). AVF closure occurred at 653 ± 441 days after kidney transplantation (KTx), with a thrombosis:ligation ratio of 19:95...
October 17, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27792654/association-between-life-s-simple-7-and-noncardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#18
Oluseye Ogunmoroti, Norrina B Allen, Mary Cushman, Erin D Michos, Tatjana Rundek, Jamal S Rana, Ron Blankstein, Roger S Blumenthal, Michael J Blaha, Emir Veledar, Khurram Nasir
BACKGROUND: The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We examined the association between the LS7 metrics and noncardiovascular disease. METHODS AND RESULTS: We studied 6506 men and women aged between 45 and 84 years, enrolled in the Multi-Ethnic Study of Atherosclerosis. Median follow-up time was 10.2 years. Each component of the LS7 metrics (smoking, body mass index, physical activity, diet, total cholesterol, blood pressure, and blood glucose) was assigned points, 0 indicates "poor" category; 1, "intermediate," and 2, "ideal...
October 20, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27782097/association-between-low-dietary-protein-intake-and-geriatric-nutrition-risk-index-in-patients-with-chronic-kidney-disease-a-retrospective-single-center-cohort-study
#19
Aki Kiuchi, Yasushi Ohashi, Reibin Tai, Toshiyuki Aoki, Sonoo Mizuiri, Toyoko Ogura, Atsushi Aikawa, Ken Sakai
Reduced dietary protein intake in malnourished patients with chronic kidney disease (CKD) may be associated with adverse clinical outcomes, which may mask any efficacy of a low-protein diet. The study included 126 patients with CKD who attended a dedicated dietary counseling clinic in 2005-2009 and were systematically followed until January 2015. Of these patients, 20 (15.9%) had moderate or severe nutrition-related risk of geriatric nutritional risk index (GNRI) < 92; these patients were more likely to be older, have a greater proteinuria, and have lower body mass index and serum albumin concentration...
October 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27779902/vitamin-d-status-and-bone-mineral-density-is-influenced-by-vitamin-d-supplementation-and-vitamin-k1-intake-in-adults-with-diabetes-and-chronic-kidney-disease
#20
Michelle R Hoffmann, Peter A Senior, Stephanie T Jackson, Guylaine Ferland, Nancy Presse, Kailash Jindal, Ping Li, Abeer S Alzaben, Diana R Mager
PURPOSE: Patients with diabetes (DM) and chronic kidney disease (CKD) are at increased risk for suboptimal bone health. The study objective was to investigate the relationships between vitamin D (vitD), vitamin K1 (vitK1), and calcium intake with bone mineral density (BMD) and vitamin D status in an ambulatory population with DM and CKD. METHODS: Adults (age 18-80 years; n = 62) with DM and CKD (stages 1-4) were recruited from the Northern Alberta Renal Program...
October 25, 2016: Canadian Journal of Dietetic Practice and Research
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