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https://www.readbyqxmd.com/read/28103659/-a-case-of-giant-prostate-carcinoma-effectively-treated-with-external-beam-radiation-therapy
#1
Sohei Kanda, Shintaro Narita, Naoki Komine, Seiichi Kitajima, Misa Yamauchi, Akihiro Sugita, Yutaka Saito, Tomonori Habuchi
We present a case of gigantic prostate tumor in a patient with castration-resistant prostate cancer with successful local control by external-beam radiation therapy. A 71-year-old man was shown to have a prostate specific antigen (PSA)level of 24.5 ng/ml, Gleason 9, cT2N1M1a, prostate adenocarcinoma with an estimated prostate volume of 26.9 g. He achieved a PSA nadir at 4 months after the initial androgen deprivation therapy and was diagnosed with castration-resistant prostate cancer three years later. Eight months after the diagnosis of castration-resistant prostate cancer, he visited our hospital due to urinary retention...
December 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28101876/extraction-of-actionable-information-from-crowdsourced-disaster-data
#2
Rungsun Kiatpanont, Uthai Tanlamai, Prabhas Chongstitvatana
Natural disasters cause enormous damage to countries all over the world. To deal with these common problems, different activities are required for disaster management at each phase of the crisis. There are three groups of activities as follows: (1) make sense of the situation and determine how best to deal with it, (2) deploy the necessary resources, and (3) harmonize as many parties as possible, using the most effective communication channels. Current technological improvements and developments now enable people to act as real-time information sources...
November 2016: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28098943/a-survey-of-the-peptide-profile-in-prato-cheese-as-measured-by-maldi-ms-and-capillary-electrophoresis
#3
Débora Parra Baptista, Francisca Diana da Silva Araújo, Marcos Nogueira Eberlin, Mirna Lúcia Gigante
In this study, we describe the characterization of the peptide profile in commercial Prato cheese by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) and capillary electrophoresis (CE). Ten commercial Prato cheese brands were characterized via their physicochemical composition and subjected to fractionation according to solubility at pH 4.6. The pH 4.6 insoluble fraction was evaluated by CE, whereas MALDI-MS was applied to the fraction soluble at pH 4.6 and in 70% ethanol. CE revealed a characteristic pattern of hydrolysis, with formation of para-κ-casein, hydrolysis of αs1 -casein at the Phe23 - Phe24 bond, and hydrolysis of β-casein...
January 18, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28081126/a-pan-lyssavirus-taqman-real-time-rt-pcr-assay-for-the-detection-of-highly-variable-rabies-virus-and-other-lyssaviruses
#4
Ashutosh Wadhwa, Kimberly Wilkins, Jinxin Gao, Rene Edgar Condori Condori, Crystal M Gigante, Hui Zhao, Xiaoyue Ma, James A Ellison, Lauren Greenberg, Andres Velasco-Villa, Lillian Orciari, Yu Li
Rabies, resulting from infection by Rabies virus (RABV) and related lyssaviruses, is one of the most deadly zoonotic diseases and is responsible for up to 70,000 estimated human deaths worldwide each year. Rapid and accurate laboratory diagnosis of rabies is essential for timely administration of post-exposure prophylaxis in humans and control of the disease in animals. Currently, only the direct fluorescent antibody (DFA) test is recommended for routine rabies diagnosis. Reverse-transcription polymerase chain reaction (RT-PCR) based diagnostic methods have been widely adapted for the diagnosis of other viral pathogens, but there is currently no widely accepted rapid real-time RT-PCR assay for the detection of all lyssaviruses...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28076606/giant-gastric-lipossarcoma-case-report-and-review-of-the-literature
#5
Jacques Matone, Samuel Okazaki, Gabriel Naman Maccapani, Thiago Trolez Amancio, Renée Zon Filippi, Antonio Luiz de Vasconcellos Macedo
Liposarcoma is one of the most common soft tissue sarcomas in adults, occurring in 15 to 20% of all patients with sarcoma. Primary liposarcoma of the stomach is rare. We report a case of patient with giant gastric liposarcoma who underwent surgery after a gastrointestinal bleeding. Preoperative hystopathological diagnosis was not established, even after three biopsy attempts. We discuss differential diagnosis, genetic causes, diagnosis strategies and treatment. RESUMO O lipossarcoma é um tipo comum de sarcomas em adultos, com incidência entre 15 e 20% entre os sarcomas...
October 2016: Einstein
https://www.readbyqxmd.com/read/28063689/associations-of-linear-growth-and-relative-weight-gain-in-early-life-with-human-capital-at-30-years-of-age
#6
Bernardo Lessa Horta, Cesar G Victora, Christian Loret de Mola, Luciana Quevedo, Ricardo Tavares Pinheiro, Denise P Gigante, Janaina Vieira Dos Santos Motta, Fernando C Barros
OBJECTIVE: To assess the associations of birthweight, nutritional status and growth in childhood with IQ, years of schooling, and monthly income at 30 years of age. STUDY DESIGN: In 1982, the 5 maternity hospitals in Pelotas, Brazil, were visited daily and 5914 live births were identified. At 30 years of age, 3701 subjects were interviewed. IQ, years of schooling, and income were measured. RESULTS: On average, their IQ was 98 points, they had 11...
January 4, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28060282/isolation-of-giant-lampbrush-chromosomes-from-living-oocytes-of-frogs-and-salamanders
#7
Joseph G Gall, Zehra F Nizami
We describe methods for studying the giant transcriptionally active lampbrush chromosomes (LBCs) found in the oocyte, or unlaid egg, of frogs and salamanders. Individual LBCs can be up to 1 mm in length and they reside in a gigantic nucleus, itself up to 0.5 mm in diameter. The large size of the chromosomes permits unparalleled observations of active genes by light optical microscopy, but at the same time special techniques are required for isolating the nucleus, removing the nuclear envelope, and spreading the chromosomes on a microscope slide...
December 5, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28051799/%C3%A2-sarcopenia-predicts-reduced-survival-in-patients-with-hepatocellular-carcinoma-at-first-diagnosis
#8
Paola Begini, Elia Gigante, Giulio Antonelli, Francesco Carbonetti, Elsa Iannicelli, Giulia Anania, Barbara Imperatrice, Adriano Maria Pellicelli, Gianfranco Delle Fave, Massimo Marignani
:  Background. Sarcopenia is a complication and independent risk factor for mortality in patients with liver cirrhosis. AIM: To assess the prevalence and influence of sarcopenia on overall survival in a cohort of cirrhotic patients with hepatocellular carcinoma managed in a tertiary center. MATERIAL AND METHODS: Abdominal computed tomography of 92 consecutive hepatocellular carcinoma cirrhotic patients, enrolled and followed from 2004 to 2014, were retrospectively studied with a software analyzing the cross-sectional areas of muscles at third lumbar vertebra level...
January 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28050489/gigantic-hand-a-rare-case-of-macrodystrophia-lipomatosa
#9
Kamal Kant Sahu, Gitesh Upender Sawatkar, Deba Prasad Dhibar, Tarun Narang
No abstract text is available yet for this article.
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049632/paleogenetic-study-of-ancient-dna-suggestive-of-x-linked-acrogigantism
#10
Albert Beckers, Daniel Fernandes, Frederic Fina, Mario Novak, Angelo Abati, Liliya Rostomyan, Albert Thiry, L'Houcine Ouafik, Bertrand Pasture, Ron Pinhasi, Adrian F Daly
Extract: Dear Editor, Pituitary gigantism is caused by chronic growth hormone (GH) hypersecretion by a pituitary lesion before epiphyseal fusion. Genetic causes have been identified in nearly 50% of patients with pituitary gigantism, with germline mutations in the AIP gene being the most frequent cause (Rostomyan et al. 2015). Recently, a new form of pituitary gigantism, X-linked acrogigantism (X-LAG), was described (Trivellin et al. 2014). X-LAG is due to chromosome Xq26.3 duplication and GPR101 is the disease-associated gene (Trivellin et al...
January 3, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28032174/septum-inferior-medial-sim-based-pedicle-a-safe-pedicle-with-well-preserved-nipple-sensation-for-reduction-in-gigantomastia
#11
Ercan Karacaoglu, Richard J Zienowicz
BACKGROUND: Reduction in breasts with well-preserved nipple sensation and a viable nipple-areola complex (NAC) is one of the basic core concepts of reduction mammoplasty. Many techniques have been described with enthusiasm advocating full achievement of the aforementioned goals. The goal of this study is to introduce a novel technique that provides an intact neurovascular source to the nipple-areola complex for reduction in gigantic breasts. PATIENTS AND METHODS: Twenty-six patients operated on from December 2010 through April 2015 were included in the study...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28031496/arthroscopic-transphyseal-anterior-cruciate-ligament-reconstruction-in-adolescent-athletes
#12
Luca Dei Giudici, Roberto Fabbrini, Luca Garro, Serena Arima, Antonio Gigante, Agostino Tucciarone
PURPOSE: To evaluate the 5-year outcome of arthroscopic transphyseal anterior cruciate ligament (ACL) reconstruction in 19 adolescent athletes. METHODS: 14 male and 5 female adolescent athletes aged 12 to 16 (mean, 13.9) years with Tanner stage 2 or 3 open physes underwent arthroscopic transphyseal ACL reconstruction by a single surgeon and were followed up for 5 years. Patients were evaluated using the numerical rating score (NRS) for pain, knee osteoarthritis outcome score (KOOS), International Knee Documentation Committee (IKDC) score, Tegner Activity Scale, and Lysholm Score, as well as the leg length discrepancy, femorotibial alignment, varus or valgus deformities, active and passive knee range of motion...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28002901/homologous-platelet-rich-plasma-for-the-treatment-of-knee-involvement-in-primary-sj%C3%A3-gren%C3%A2-s-syndrome
#13
C Bottegoni, L Farinelli, A Aquili, E Chiurazzi, A Gigante
Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by dry eyes, dry mouth, and other clinical manifestations. The most common extraglandular manifestation of pSS is articular involvement and to date their management is unclear. The aims of the current pilot study were to assess the safety and the outcomes of homologous platelet-rich plasma (HPRP) injections in pSS cohort affected by knee arthralgia/arthritis at short-term follow up. This pilot study provides the first evidence that HPRP injections are a safe treatment and induce a short-term clinical improvement...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28002894/effect-of-nerve-growth-factor-on-cultured-human-chondrocytes
#14
A Gigante, L Senesi, S Manzotti, A Palmieri, E Skrami, V Sollazzo
Nerve growth factor (NGF) is involved in several joint diseases. It participates in nociception and neurogenic inflammation and its concentrations increase in synovial fluid and tissue from arthritis. However, data about its role in articular cartilage are scant and conflicting. This study analysed effects of different NGF concentrations on cultured human chondrocytes by evaluating cell proliferation, cell phenotype, and gene expression. The MTT test excluded an influence on cell viability. Alcian blue and S100 staining demonstrated that NGF may induce de-differentiation of the chondrocyte phenotype...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27998914/human-igm-antibodies-to-malondialdehyde-conjugated-with-albumin-are-negatively-associated-with-cardiovascular-disease-among-60-year-olds
#15
Divya Thiagarajan, Anna G Frostegård, Sudhir Singh, Mizanur Rahman, Anquan Liu, Max Vikström, Karin Leander, Bruna Gigante, Mai-Lis Hellenius, Bo Zhang, Roman A Zubarev, Ulf de Faire, Susanna L Lundström, Johan Frostegård
BACKGROUND: Malondialdehyde (MDA) is generated during lipid peroxidation as in oxidized low-density lipoprotein, but antibodies against oxidized low-density lipoprotein show variable results in clinical studies. We therefore studied the risk of cardiovascular disease (CVD) associated with IgM antibodies against MDA conjugated with human albumin (anti-MDA). METHODS AND RESULTS: In a 5- to 7-year follow-up of 60-year-old men and women from Stockholm County previously screened for cardiovascular risk factors (2039 men, 2193 women), 209 incident CVD cases (defined as new events of coronary heart disease, fatal and nonfatal myocardial infarction, ischemic stroke, and hospitalization for angina pectoris) and 620 age- and sex-matched controls were tested for IgM anti-MDA by ELISA...
December 20, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27989673/phylogenomics-and-morphology-of-extinct-paleognaths-reveal-the-origin-and-evolution-of-the-ratites
#16
Takahiro Yonezawa, Takahiro Segawa, Hiroshi Mori, Paula F Campos, Yuichi Hongoh, Hideki Endo, Ayumi Akiyoshi, Naoki Kohno, Shin Nishida, Jiaqi Wu, Haofei Jin, Jun Adachi, Hirohisa Kishino, Ken Kurokawa, Yoshifumi Nogi, Hideyuki Tanabe, Harutaka Mukoyama, Kunio Yoshida, Armand Rasoamiaramanana, Satoshi Yamagishi, Yoshihiro Hayashi, Akira Yoshida, Hiroko Koike, Fumihito Akishinonomiya, Eske Willerslev, Masami Hasegawa
The Palaeognathae comprise the flightless ratites and the volant tinamous, and together with the Neognathae constitute the extant members of class Aves. It is commonly believed that Palaeognathae originated in Gondwana since most of the living species are found in the Southern Hemisphere [1-3]. However, this hypothesis has been questioned because the fossil paleognaths are mostly from the Northern Hemisphere in their earliest time (Paleocene) and possessed many putative ancestral characters [4]. Uncertainties regarding the origin and evolution of Palaeognathae stem from the difficulty in estimating their divergence times [1, 2] and their remarkable morphological convergence...
January 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/27982127/tuning-magnetic-spirals-beyond-room-temperature-with-chemical-disorder
#17
Mickaël Morin, Emmanuel Canévet, Adrien Raynaud, Marek Bartkowiak, Denis Sheptyakov, Voraksmy Ban, Michel Kenzelmann, Ekaterina Pomjakushina, Kazimierz Conder, Marisa Medarde
In the past years, magnetism-driven ferroelectricity and gigantic magnetoelectric effects have been reported for a number of frustrated magnets featuring ordered spiral magnetic phases. Such materials are of high-current interest due to their potential for spintronics and low-power magnetoelectric devices. However, their low-magnetic ordering temperatures (typically <100 K) greatly restrict their fields of application. Here we demonstrate that the onset temperature of the spiral phase in the perovskite YBaCuFeO5 can be increased by more than 150 K through a controlled manipulation of the Fe/Cu chemical disorder...
December 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27975292/network-tools-for-the-analysis-of-proteomic-data
#18
David Chisanga, Shivakumar Keerthikumar, Suresh Mathivanan, Naveen Chilamkurti
Recent advancements in high-throughput technologies such as mass spectrometry have led to an increase in the rate at which data is generated and accumulated. As a result, standard statistical methods no longer suffice as a way of analyzing such gigantic amounts of data. Network analysis, the evaluation of how nodes relate to one another, has over the years become an integral tool for analyzing high throughput proteomic data as they provide a structure that helps reduce the complexity of the underlying data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27930299/imaging-the-he2-quantum-halo-state-using-a-free-electron-laser
#19
Stefan Zeller, Maksim Kunitski, Jörg Voigtsberger, Anton Kalinin, Alexander Schottelius, Carl Schober, Markus Waitz, Hendrik Sann, Alexander Hartung, Tobias Bauer, Martin Pitzer, Florian Trinter, Christoph Goihl, Christian Janke, Martin Richter, Gregor Kastirke, Miriam Weller, Achim Czasch, Markus Kitzler, Markus Braune, Robert E Grisenti, Wieland Schöllkopf, Lothar Ph H Schmidt, Markus S Schöffler, Joshua B Williams, Till Jahnke, Reinhard Dörner
Quantum tunneling is a ubiquitous phenomenon in nature and crucial for many technological applications. It allows quantum particles to reach regions in space which are energetically not accessible according to classical mechanics. In this "tunneling region," the particle density is known to decay exponentially. This behavior is universal across all energy scales from nuclear physics to chemistry and solid state systems. Although typically only a small fraction of a particle wavefunction extends into the tunneling region, we present here an extreme quantum system: a gigantic molecule consisting of two helium atoms, with an 80% probability that its two nuclei will be found in this classical forbidden region...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27915246/neutrophil-dependent-pentraxin-3-and-reactive-oxygen-species-production-modulate-endothelial-dysfunction-in-haemodialysis-patients
#20
Maria Pia dell'Oglio, Simona Simone, Marco Ciccone, Roberto Corciulo, Michele Gesualdo, Annapaola Zito, Francesca Cortese, Giuseppe Castellano, Margherita Gigante, Loreto Gesualdo, Giuseppe Grandaliano, Giovanni Battista Pertosa
BACKGROUND: The aim of this study was to investigate neutrophil activation and its role in long pentraxin-3 (PTX3) release and oxidative stress generation during haemodialysis (HD) and to correlate neutrophil PTX3 and oxidant expression with endothelial dysfunction. METHODS: Forty-seven uraemic patients on stable HD, 12 healthy subjects and 15 patients with congestive heart failure (New York Heart Association classes III and IV) were enrolled. Neutrophil PTX3 protein expression was evaluated by confocal microscopy...
December 3, 2016: Nephrology, Dialysis, Transplantation
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