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https://www.readbyqxmd.com/read/28905978/redesign-of-computerized-decision-support-to-improve-antimicrobial-prescribing-a-controlled-before-and-after-study
#1
Melissa Baysari, Melissa T Baysari, Jessica Del Gigante, Maria Moran, Indy Sandaradura, Ling Li, Katrina L Richardson, Anmol Sandhu, Elin C Lehnbom, Johanna I Westbrook, Richard O Day
OBJECTIVE: To determine the impact of the introduction of new pre-written orders for antimicrobials in a computerized provider order entry (CPOE) system on 1) accuracy of documented indications for antimicrobials in the CPOE system, 2) appropriateness of antimicrobial prescribing, and 3) compliance with the hospital's antimicrobial policy. Prescriber opinions of the new decision support were also explored to determine why the redesign was effective or ineffective in altering prescribing practices...
September 13, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28884905/macrodystrophia-lipomatosa
#2
Tyler Willenbrink, Lindsay Thelin, Gregory Connor, Lucia Diaz
Macrodystrophia lipomatosa is an exceedingly rare overgrowth of mesenchymal and fibroadipose tissue manifesting as a form of gigantism affecting one or more digits on the distal upper or lower extremities. We present a 25-year-old man who presented with overgrowth of the right hand associated with occasional pain, numbness, and limited function who was found to have macrodystrophia lipomatosa with fibrolipomatous hamartoma of the median nerve. Reports of this condition are limited in the dermatology literature, and early recognition can lead to better outcomes...
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28880329/exploiting-le-chatelier-s-principle-for-a-one-pot-synthesis-of-nontoxic-hhoggnps-with-the-sharpest-nanoscopic-features-suitable-for-tunable-plasmon-spectroscopy-and-high-throughput-sers-sensing
#3
M Bhattacharya, V Mazov, B Satpati, P Jena, S Das Chakraborty, S Kumar, B Pathak, D V Kuznetsov, D Senapati
Applying Le Chatelier's principle, a one-pot synthesis method is reported that generates highly anisotropic hedgehog gold nanoparticles (HHogGNPs), undemanding of a preformed seed or surfactant. These non-toxic HHogGNPs are potent candidates for nanomedicinal applications owing to their broad-band plasmon tunability, gigantic Raman enhancement and remarkable retention in a highly salted physiological environment.
September 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28833295/employment-of-modified-fe%C3%A2-o%C3%A2-nanoparticles-using-thermo-sensitive-polymer-for-extraction-and-pre-concentration-of-cefexime-in-biological-samples
#4
Saman Naghibi, Hamed Sahebi
Cefexime as a useful antibiotic can be prescribed to treat infections resulted by bacteria. Nowadays nanoparticles have been widely marked as a universal utopia among many scientists. Variety of researches has been taken place to modify nanoparticles to make them functional as extraction and pre-concentration agents and drug carriers. Temperature-sensitive polymer belongs to a group of substances which perform a gigantic change in their physical features in response to the temperature. Recent polymer can be widely used in different areas, including modification of nanoparticles...
August 19, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28821782/rapid-dwarfing-of-an-insular-mammal-the-feral-cattle-of-amsterdam-island
#5
Roberto Rozzi, Mark V Lomolino
The island rule describes a graded trend in insular populations of vertebrates from gigantism in small species to dwarfism in large species. The dwarfing of large mammals on islands has been observed both in the present fauna and in the fossil record. Elephants, hippopotami, deer, and other species became dwarfed on islands scattered all over the world, from the Mediterranean Sea to Indonesia, from the Eastern to Western Pacific Ocean, from the Caribbean to Canary Islands. The most rapid and well documented cases of island dwarfing known thus far took place over thousands of years...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817218/bmi-nephroangiosclerosis-and-glomerulonephritis-is-there-any-meeting-point
#6
Antonietta Gigante, Konstantinos Giannakakis, Francesca Di Mario, Biagio Barbano, Edoardo Rosato, Riccardo Pofi, Marcello Di Paolo, Anna Rachele Rocca, Rosario Cianci
BACKGROUND: Overweight has been related to renal arteriolosclerosis and is able to modify intrarenal hemodynamics. Increasing evidences suggest an association between weight excess and primary glomerulonephritis (GN). The aim of this study was to evaluate the relationship between nutritional status and intrarenal arterial stiffness in primary GN associated to arteriolosclerosis. We have considered the glomerular diameter (GD) as morphological parameter in overweight and obese patients...
August 17, 2017: Nephrology
https://www.readbyqxmd.com/read/28816991/a-case-report-of-tracheal-inflammatory-myofibroblastic-tumor-in-a-34-week-pregnant-woman-misdiagnosed-with-asthma
#7
Xiaochen Li, Juan Li, Xiaoling Rao, Qilin Ao, Xiaopei Cao, Yali Huang, Shengding Zhang, Xiaoyu Fang, Xiansheng Liu, Min Xie
RATIONALE: Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplastic entity with a tendency of local recurrence and a low risk of distant metastasis. Involvement of trachea is extremely rare. PATIENT CONCERNS: A 34-week pregnant woman previously diagnosed with asthma for 2 months was admitted with persistent wheezing and hemoptysis. A computed tomography scan and bronchoscopy revealed a gigantic polyp in the trachea. DIAGNOSES: Tracheal inflammatory myofibroblastic tumor...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28794222/a-new-giant-titanosaur-sheds-light-on-body-mass-evolution-among-sauropod-dinosaurs
#8
José L Carballido, Diego Pol, Alejandro Otero, Ignacio A Cerda, Leonardo Salgado, Alberto C Garrido, Jahandar Ramezani, Néstor R Cúneo, Javier M Krause
Titanosauria was the most diverse and successful lineage of sauropod dinosaurs. This clade had its major radiation during the middle Early Cretaceous and survived up to the end of that period. Among sauropods, this lineage has the most disparate values of body mass, including the smallest and largest sauropods known. Although recent findings have improved our knowledge on giant titanosaur anatomy, there are still many unknown aspects about their evolution, especially for the most gigantic forms and the evolution of body mass in this clade...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28780279/personality-disorders-and-somatization-in-functional-and-organic-movement-disorders
#9
Giovanni Defazio, Adriana Pastore, Roberta Pellicciari, Grazia Pierri, Angelo F Gigante, Giada Fabio, Maria Superbo, Francesco Margari
Psychiatric disturbances and somatizations are both criteria which support the diagnosis of functional movement disorders. It is unclear, however, whether these factors are helpful in differentiating functional and organic movement disorders. To address this issue, the Structured Clinical Interview for DSM-IV Axis I and II psychiatric disorders, the State-Trait Anxiety Inventory, the Beck Depression Inventory and the "somatization section" of the Dissociative Disorders Interview Schedule were administered to 31 functional movement disorder patients diagnosed, according to Fahn and Williams criteria and 31 sex- and age-matched control outpatients, with adult-onset dystonia...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28762208/two-novel-poxviruses-with-unusual-genome-rearrangements-ny_014-and-murmansk
#10
Chad Smithson, Hermann Meyer, Crystal M Gigante, Jinxin Gao, Hui Zhao, Dhwani Batra, Inger Damon, Chris Upton, Yu Li
The genome sequence and annotation of two novel poxviruses, NY_014 and Murmansk, are presented. Despite being isolated on different continents and from different hosts, the viruses are relatively similar, albeit distinct species. The closest known relative of the novel viruses is Yoka poxvirus. Five novel genes were found in these genomes, two of which were MHC class I homologs. Although the core of these genomes was well conserved, the terminal regions showed significant variability with large deletions and surprising evidence of recombination with orthopoxviruses...
July 31, 2017: Virus Genes
https://www.readbyqxmd.com/read/28758856/clinicopathological-characteristics-and-experience-in-the-treatment-of-giant-retroperitoneal-liposarcoma-a-case-report-and-review-of-the-literature
#11
Xiangyu Zeng, Weizhen Liu, Xiuli Wu, Jinbo Gao, Peng Zhang, Xiaoming Shuai, Kaixiong Tao
Retroperitoneal liposarcoma (RPLS) is a rare tumor, especailly those over 20 kg that are called "giant liposarcoma," whose characteristics and treatments remain relatively unknown. Herein, we report a giant RPLS measuring 65 × 45 × 30 cm in diameter and 31 kg in weight, which we successfully performed complete excision through interdisciplinary cooperation. The patient had an uneventful postoperative course and was discharged without complications. Afterwards he underwent radiotherapy and had no evidence of tumor recurrence or symptoms of metastasis at 3-month CT scan and 8-month follow-up...
July 31, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28746591/the-therapeutic-challenge-of-giant-splenic-artery-aneurysm-a-case-repport
#12
Paulo Kauffman, Antonio Luiz de Vasconcellos Macedo, Roberto Sacilotto, Adriano Tachibana, Sergio Kuzniec, Lucas Lembrança Pinheiro, Nelson Wolosker
Giant splenic artery aneurysm is a rare condition that represents an eminent life threatening for the patient, requiring, therefore, urgent surgical correction. A 61-year-old woman, former smoker, hypertensive, hypercholesterolemic and multipara sought our service because of a large tumor in the mesogastrium, which was an abdominal ultrasound finding. Despite the size of the tumor, the patient was asymptomatic. The angiotomography and the magnetic resonance image of the abdomen were suggestive of giant splenic artery aneurysm with more than 10cm in diameter that was confirmed by an angiography...
July 24, 2017: Einstein
https://www.readbyqxmd.com/read/28726888/a-gigantic-polyoxozirconate-with-visible-photoactivity
#13
Tingting Xu, Xudong Hou, Yang Wang, Jun Zhang, Junxiang Zhang, Bo Liu
We present a gigantic polyoxozirconate nanocluster (Zr18O21(μ2-OH)2(OOCPh)28), involving 6, 7 and 8-coordinated Zr atoms. It exhibits visible light driven photocatalytic activity for H2 evolution. The current results could represent a prelude of polyoxozirconate-based photocatalysis.
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28723385/grey-zone-urinary-incontinence
#14
Andrea Tubaro, Arjun K Nambiar
Providing high-quality evidence in the field of urinary incontinence is difficult because the value of diagnostic tests must be evaluated through the filter of treatment outcome, and surgical treatments include an unavoidable amount of intrinsic variability. The scientific community should be commended for the gigantic effort made over the years to provide evidence upon which proper patient management can be based.
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722322/advanced-methods-for-dose-and-regimen-finding-during-drug-development-summary-of-the-ema-efpia-workshop-on-dose-finding-london-4-5-december-2014
#15
F T Musuamba, E Manolis, N Holford, Sya Cheung, L E Friberg, K Ogungbenro, M Posch, Jwt Yates, S Berry, N Thomas, S Corriol-Rohou, B Bornkamp, F Bretz, A C Hooker, P H Van der Graaf, J F Standing, J Hay, S Cole, V Gigante, K Karlsson, T Dumortier, N Benda, F Serone, S Das, A Brochot, F Ehmann, R Hemmings, I Skottheim Rusten
Inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and postmarketing commitments required by regulatory institutions. In an effort to shift the current paradigm in dose and regimen selection and highlight the availability and usefulness of well-established and regulatory-acceptable methods, the European Medicines Agency (EMA) in collaboration with the European Federation of Pharmaceutical Industries Association (EFPIA) hosted a multistakeholder workshop on dose finding (London 4-5 December 2014)...
July 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28716925/symmetry-related-proton-transfer-pathways-in-respiratory-complex-i
#16
Andrea Di Luca, Ana P Gamiz-Hernandez, Ville R I Kaila
Complex I functions as the initial electron acceptor in aerobic respiratory chains of most organisms. This gigantic redox-driven enzyme employs the energy from quinone reduction to pump protons across its complete approximately 200-Å membrane domain, thermodynamically driving synthesis of ATP. Despite recently resolved structures from several species, the molecular mechanism by which complex I catalyzes this long-range proton-coupled electron transfer process, however, still remains unclear. We perform here large-scale classical and quantum molecular simulations to study the function of the proton pump in complex I from Thermus thermophilus The simulations suggest that proton channels are established at symmetry-related locations in four subunits of the membrane domain...
August 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28713720/a-rare-case-of-extra-gigantic-digit-of-sole
#17
Chetan Satish, Subhash Reddy
No abstract text is available yet for this article.
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28705195/peto-s-paradox-how-has-evolution-solved-the-problem-of-cancer-prevention
#18
Marc Tollis, Amy M Boddy, Carlo C Maley
The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto's Paradox. We discuss what is known about Peto's Paradox and provide hints of what is yet to be discovered.
July 13, 2017: BMC Biology
https://www.readbyqxmd.com/read/28694425/insight-into-microtubule-disassembly-by-kinesin-13s-from-the-structure-of-kif2c-bound-to-tubulin
#19
Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang, Benoît Gigant
Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functional construct of the kinesin-13 Kif2C/MCAK in an ATP-like state and bound to the αβ-tubulin heterodimer, a complex mimicking the species that dissociates from microtubule ends during catalytic disassembly. Our results picture how Kif2C stabilizes a curved tubulin conformation. The Kif2C α4-L12-α5 region undergoes a remarkable 25° rotation upon tubulin binding to target the αβ-tubulin hinge...
July 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28693499/conditions-of-gestation-childbirth-and-childhood-associated-with-c-peptide-in-young-adults-in-the-1982-birth-cohort-in-pelotas-rs-brazil
#20
Romildo Luiz Monteiro Andrade, Denise Petrucci Gigante, Isabel Oliveira de Oliveira, Bernardo Lessa Horta
BACKGROUND: The connecting peptide in insulin has been associated with cardiovascular risk and overall mortality in the adult population. However, its early determinants are unknown. Assess the association of exposures during pregnancy, delivery, and childhood with C-peptide among 22-23 years old individuals prospectively followed since birth, in a southern Brazilian city. METHODS: In 1982, all hospital births in the city were identified and those livebirths whose families lived in the urban area were evaluated (n = 5914)...
July 11, 2017: BMC Cardiovascular Disorders
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