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https://www.readbyqxmd.com/read/29149017/the-ms6-mycolyl-arabinogalactan-esterase-lysb-is-essential-for-an-efficient-mycobacteriophage-induced-lysis
#1
Adriano M Gigante, Cheri M Hampton, Rebecca S Dillard, Filipa Gil, Maria João Catalão, José Moniz-Pereira, Elizabeth R Wright, Madalena Pimentel
All dsDNA phages encode two proteins involved in host lysis, an endolysin and a holin that target the peptidoglycan and cytoplasmic membrane, respectively. Bacteriophages that infect Gram-negative bacteria encode additional proteins, the spanins, involved in disruption of the outer membrane. Recently, a gene located in the lytic cassette was identified in the genomes of mycobacteriophages, which encodes a protein (LysB) with mycolyl-arabinogalactan esterase activity. Taking in consideration the complex mycobacterial cell envelope that mycobacteriophages encounter during their life cycle, it is valuable to evaluate the role of these proteins in lysis...
November 17, 2017: Viruses
https://www.readbyqxmd.com/read/29134094/the-evolution-of-giant-flightless-birds-and-novel-phylogenetic-relationships-for-extinct-fowl-aves-galloanseres
#2
Trevor H Worthy, Federico J Degrange, Warren D Handley, Michael S Y Lee
The extinct dromornithids, gastornithids and phorusrhacids are among the most spectacular birds to have ever lived, with some giants exceeding 500 kg. The affinities and evolution of these and other related extinct birds remain contentious, with previous phylogenetic analyses being affected by widespread convergence and limited taxon sampling. We address these problems using both parsimony and tip-dated Bayesian approaches on an expansive taxon set that includes all key extinct flightless and flighted (e...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133572/drug-repositioning-meets-precision-in-glioblastoma
#3
Wolfgang Wick, Tobias Kessler
Glioblastoma has a gigantic unmet medical need. Molecular knowledge has evolved substantially, including data on clonal selection with progression. Past trials for all-comers may have produced false negative results. Molecular precision at progression needs workup of new tissue and revisiting drugs with focus on brain tumor penetration may yield surprises.
November 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29132687/pliocene-crocodiles-from-kanapoi-turkana-basin-kenya
#4
Christopher A Brochu
Three crocodylid species are known from the Pliocene Kanapoi locality in the western Turkana Basin. One of these, Crocodylus thorbjarnarsoni, includes material previously referred to Crocodylus niloticus (the modern Nile crocodile currently living in Lake Turkana) and Rimasuchus lloydi. C. thorbjarnarsoni was a gigantic horned crocodile similar in overall shape to most other generalized crocodylids, but its closest known relative is another extinct species, Crocodylus anthropophagus from the Pleistocene of Olduvai Gorge in Tanzania...
November 10, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29124259/correction-a-metal-free-fluorescence-turn-on-molecular-probe-for-detection-of-nucleoside-triphosphates
#5
Debabrata Maity, Mao Li, Martin Ehlers, Alba Gigante, Carsten Schmuck
Correction for 'A metal-free fluorescence turn-on molecular probe for detection of nucleoside triphosphates' by Debabrata Maity et al., Chem. Commun., 2017, 53, 208-211.
November 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29108078/-big-data-and-public-health-results-of-the-working-group-1-of-the-forum-future-public-health-berlin-2016
#6
Susanne Moebus, Joseph Kuhn, Wolfgang Hoffmann
Big Data is a diffuse term, which can be described as an approach to linking gigantic and often unstructured data sets. Big Data is used in many corporate areas. For Public Health (PH), however, Big Data is not a well-developed topic. In this article, Big Data is explained according to the intention of use, information efficiency, prediction and clustering. Using the example of application in science, patient care, equal opportunities and smart cities, typical challenges and open questions of Big Data for PH are outlined...
November 6, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29106927/desquamating-rash-in-a-patient-with-undiagnosed-netherton-syndrome
#7
Matthew A De Niear, Joseph Gigante
No abstract text is available yet for this article.
October 26, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29100090/exome-wide-association-study-identifies-greb1l-mutations-in-congenital-kidney-malformations
#8
Simone Sanna-Cherchi, Kamal Khan, Rik Westland, Priya Krithivasan, Lorraine Fievet, Hila Milo Rasouly, Iuliana Ionita-Laza, Valentina P Capone, David A Fasel, Krzysztof Kiryluk, Sitharthan Kamalakaran, Monica Bodria, Edgar A Otto, Matthew G Sampson, Christopher E Gillies, Virginia Vega-Warner, Katarina Vukojevic, Igor Pediaditakis, Gabriel S Makar, Adele Mitrotti, Miguel Verbitsky, Jeremiah Martino, Qingxue Liu, Young-Ji Na, Vinicio Goj, Gianluigi Ardissino, Maddalena Gigante, Loreto Gesualdo, Magdalena Janezcko, Marcin Zaniew, Cathy Lee Mendelsohn, Shirlee Shril, Friedhelm Hildebrandt, Joanna A E van Wijk, Adela Arapovic, Marijan Saraga, Landino Allegri, Claudia Izzi, Francesco Scolari, Velibor Tasic, Gian Marco Ghiggeri, Anna Latos-Bielenska, Anna-Materna Kiryluk, Shrikant Mane, David B Goldstein, Richard P Lifton, Nicholas Katsanis, Erica E Davis, Ali G Gharavi
Renal agenesis and hypodysplasia (RHD) are major causes of pediatric chronic kidney disease and are highly genetically heterogeneous. We conducted whole-exome sequencing in 202 case subjects with RHD and identified diagnostic mutations in genes known to be associated with RHD in 7/202 case subjects. In an additional affected individual with RHD and a congenital heart defect, we found a homozygous loss-of-function (LOF) variant in SLIT3, recapitulating phenotypes reported with Slit3 inactivation in the mouse...
November 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29091914/a-new-giraffid-mammalia-ruminantia-pecora-from-the-late-miocene-of-spain-and-the-evolution-of-the-sivathere-samothere-lineage
#9
María Ríos, Israel M Sánchez, Jorge Morales
Giraffids include the only living giraffomorph ruminants and are diagnosed by the presence of bi-lobed canines and a special type of epiphyseal cranial appendages called ossicones. The family Giraffidae ranges from the latest early Miocene until today. However they are currently extant relics with only two living representatives, the African genera Okapia and Giraffa. Giraffids were much more diverse and widespread in the past, with more than 30 fossil species described. For the past decades a number of studies intended to resolve the phylogenetic relationships of the family, but due to the lack of really good cranial material no clear consensus was reached regarding the phylogenetic relationships amongst the different members of the group...
2017: PloS One
https://www.readbyqxmd.com/read/29090008/automated-flow-cytometry-an-alternative-to-urine-culture-in-a-routine-clinical-microbiology-laboratory
#10
REVIEW
Patricia Mejuto, Mariam Luengo, Julio Díaz-Gigante
The urine culture is the "gold standard" for the diagnosis of urinary tract infections (UTI) but constitutes a significant workload in the routine clinical laboratory. Due to the high percentage of negative results, there is a need for an efficient screening method, with a high negative predictive value (NPV) that could reduce the number of unnecessary culture tests. With the purpose of improving the efficiency of laboratory work, several methods for screening out the culture-negative samples have been developed, but none of them has shown adequate sensitivity (SE) and high NPV...
2017: International Journal of Microbiology
https://www.readbyqxmd.com/read/29074612/aip-mutations-in-brazilian-patients-with-sporadic-pituitary-adenomas-a-single-center-evaluation
#11
Paula Bruna Araujo, Leandro Kasuki, Carlos Henrique de Azeredo Lima, Liana Lumi Ogino, Aline H S Camacho, Leila Chimelli, Marta Korbonits, Monica R Gadelha
Aryl hydrocarbon receptor-interacting protein (AIP) gene mutations (AIPmut) are the most frequent germline mutations found in apparently sporadic pituitary adenomas (SPA). Our aim was to evaluate the frequency of AIPmut among young Brazilian patients with SPA. We performed an observational cohort study between 2013-2016 in a single referral center. AIPmut screening was carried out in 132 SPA patients with macroadenomas diagnosed up to 40 years, or in adenomas of any size diagnosed until 18 years of age. Twelve tumor samples were also analyzed...
October 26, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29067735/an-as4-cu4-cu-h2-o-12-cluster-incorporated-within-four-nb7-o22-9-units
#12
Li Li, Kaili Dong, Pengtao Ma, Chao Zhang, Jingyang Niu, Jingping Wang
A gigantic 16-copper-containing 28-niobate cluster, Na14 K7 H5 {As4 Cu4 [Cu(H2 O)]12 Nb28 O109 }⋅37.5 H2 O (1), has been prepared by a one-pot reaction, which is the first example of arsenic copper clusters containing polyoxoniobate, and the first tetrahedral arrangement of both the Cu cluster and the [Nb7 O22 ](9-) subunits.
October 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29059986/energy-efficient-lora-gps-tracker-for-dementia-patients
#13
Tim Hadwen, Vanessa Smallbon, Qing Zhang, Matthew D'Souza
Continuous GPS tracking devices always suffer short battery life when used by caregivers to reduce the risk of wandering to dangerous areas by dementia patients. Currently the best existing tracker for dementia patients on the market only supports less than 10 hours battery life with a gigantic battery. It not only requires daily battery charging from patients/caregivers, but also becomes a very restrictive device. In this paper we inspected individual energy consumption of the components in a GPS tracker and proposed a novel energy efficient, small wristband by integrating the latest LoRa communication and GPS duty cycling technologies...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058024/management-of-renal-transplant-urolithiasis-a-multicentre-study-by-the-french-urology-association-transplantation-committee
#14
J Branchereau, M O Timsit, Y Neuzillet, T Bessède, R Thuret, M Gigante, X Tillou, R Codas, J Boutin, A Doerfler, F Sallusto, T Culty, V Delaporte, N Brichart, B Barrou, L Salomon, G Karam, J Rigaud, L Badet, F Kleinklauss
PURPOSE: Urolithiasis is rare among renal transplant recipients and its management has not been clearly defined. METHODS: This multicentre retrospective study was organised by the Comité de Transplantation de l'Association Française d'Urologie (French Urology Association transplantation committee). Statistical analysis was performed with SPSS 19 software. RESULTS: Ninety-five patients were included in this study. Renal transplant urolithiasis was an incidental finding in 55% of cases, mostly on a routine follow-up ultrasound examination...
October 22, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29032841/circulating-fatty-acids-in-relation-to-alcohol-consumption-cross-sectional-results-from-a-cohort-of-60-year-old-men-and-women
#15
F Laguzzi, U Risérus, M Marklund, M Vikström, P Sjögren, B Gigante, Z D Alsharari, M-L Hellénius, T Cederholm, P Frumento, U de Faire, K Leander
BACKGROUND & AIMS: Alcohol consumption is considered to affect circulating fatty acids (FAs) but knowledge about specific associations is limited. We aimed to assess the relation between alcohol consumption and serum FAs in 60-year-old Swedish men and women. METHODS: In a random sample of 1917 men and 2058 women residing in Stockholm county, cross-sectional associations between different categories of alcohol consumption and FAs were assessed using linear regression; β1 coefficients with 95% confidence interval (CI) were calculated...
September 25, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29027525/-gigantic-aneurysm-of-the-coronary-artery
#16
P V Chumachenko, M A Afanasyev, I E Galankina, L N Ilyina, A Yu Postnov
The paper describes a clinical case of gigantic aneurysm of one of the coronary arteries. It considers the morphological and immunohistochemical characteristics of the wall of the blood vessel with the detected signs of coronaritis. The authors have determined that Kawasaki disease could be retrospectively diagnosed in early childhood.
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29025393/molecular-basis-of-african-yam-domestication-analyses-of-selection-point-to-root-development-starch-biosynthesis-and-photosynthesis-related-genes
#17
Roland Akakpo, Nora Scarcelli, Hana Chaïr, Alexandre Dansi, Gustave Djedatin, Anne-Céline Thuillet, Bénédicte Rhoné, Olivier François, Karine Alix, Yves Vigouroux
BACKGROUND: After cereals, root and tuber crops are the main source of starch in the human diet. Starch biosynthesis was certainly a significant target for selection during the domestication of these crops. But domestication of these root and tubers crops is also associated with gigantism of storage organs and changes of habitat. RESULTS: We studied here, the molecular basis of domestication in African yam, Dioscorea rotundata. The genomic diversity in the cultivated species is roughly 30% less important than its wild relatives...
October 12, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28992707/-overgrowth-in-children-and-in-adults-novel-clinical-view-novel-genes-novel-phenotypes
#18
Jan Lebl, Lukáš Plachý, Květa Bláhová, Lenka Elblová, Filip Fencl, Stanislava Koloušková, Štěpánka Průhová
Novel genetic findings allow to more reliably elucidate the aetiology and pathogenesis of overgrowth syndromes in children and in adults. The relatively prevalent overgrowth syndromes in foetuses and neonates include Beckwith-Wiedemann (BWS) and Sotos syndromes; in addition, several rare conditions may occur e.g. Simpson-Golabi-Behmel and Weaver syndromes. These syndromes are not connected with overproduction of growth hormone. Their carriers are at risk of hypoglycaemia (in BWS), of congenital malformations and of childhood tumours...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28992140/inflammation-induces-osteoclast-differentiation-from-peripheral-mononuclear-cells-in-chronic-kidney-disease-patients-crosstalk-between-the-immune-and-bone-systems
#19
Cesira Cafiero, Margherita Gigante, Giacomina Brunetti, Simona Simone, Nada Chaoul, Angela Oranger, Elena Ranieri, Silvia Colucci, Giovanni B Pertosa, Maria Grano, Loreto Gesualdo
Background: Inflammation and immune system alterations contribute to bone damage in many pathologies by inducing the differentiation of osteoclasts (OCs), the bone resorbing cells. This link is largely unexplored in chronic kidney disease (CKD) and haemodialysis (HD) patients, in which reduced renal function is accompanied by an increased inflammatory state and skeletal abnormality. Methods: We used ex vivo culture experiments to investigate the osteoclastogenic potential of peripheral blood mononuclear cells (PBMCs) of CKD and HD patients, focusing on immune cell subsets and inflammatory cytokines such as LIGHT and receptor activator of nuclear factor κB ligand (RANKL)...
July 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28989967/tailoring-tricolor-structure-of-magnetic-topological-insulator-for-robust-axion-insulator
#20
Masataka Mogi, Minoru Kawamura, Atsushi Tsukazaki, Ryutaro Yoshimi, Kei S Takahashi, Masashi Kawasaki, Yoshinori Tokura
Exploration of novel electromagnetic phenomena is a subject of great interest in topological quantum materials. One of the unprecedented effects to be experimentally verified is the topological magnetoelectric (TME) effect originating from an unusual coupling of electric and magnetic fields in materials. A magnetic heterostructure of topological insulator (TI) hosts such exotic magnetoelectric coupling and can be expected to realize the TME effect as an axion insulator. We designed a magnetic TI with a tricolor structure where a nonmagnetic layer of (Bi, Sb)2Te3 is sandwiched by a soft ferromagnetic Cr-doped (Bi, Sb)2Te3 and a hard ferromagnetic V-doped (Bi, Sb)2Te3...
October 2017: Science Advances
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