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https://www.readbyqxmd.com/read/28226231/cell-biology-of-the-plant-nucleus
#1
Iris Meier, Eric J Richards, David E Evans
The eukaryotic nucleus is enclosed by the nuclear envelope, which is perforated by the nuclear pores, the gateways of macromolecular exchange between the nucleoplasm and cytoplasm. The nucleoplasm is organized in a complex three-dimensional fashion that changes over time and in response to stimuli. Within the cell, the nucleus must be viewed as an organelle (albeit a gigantic one) that is a recipient of cytoplasmic forces and capable of morphological and positional dynamics. The most dramatic reorganization of this organelle occurs during mitosis and meiosis...
February 22, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/28220886/earth-s-oldest-bobbit-worm-gigantism-in-a-devonian-eunicidan-polychaete
#2
Mats E Eriksson, Luke A Parry, David M Rudkin
Whilst the fossil record of polychaete worms extends to the early Cambrian, much data on this group derive from microfossils known as scolecodonts. These are sclerotized jaw elements, which generally range from 0.1-2 mm in size, and which, in contrast to the soft-body anatomy, have good preservation potential and a continuous fossil record. Here we describe a new eunicidan polychaete, Websteroprion armstrongi gen. et sp. nov., based primarily on monospecific bedding plane assemblages from the Lower-Middle Devonian Kwataboahegan Formation of Ontario, Canada...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217162/a-rare-case-of-giant-occipital-meningocele-with-dandy-walker-syndrome-can-it-grow-bigger-than-this
#3
Dipanker Singh Mankotia, Guru Dutta Satyarthee, Bhoopendra Singh, Bhawani Shankar Sharma
Association of Dandy-Walker syndrome with occipital meningocele (OMC) is extremely rare and about thirty cases are reported till date in the Western literature. However, OMC is classified by Talamonti et al. into small, large, and giant categories with respective diameters were upto 5 cm in small, large with 5-9 cm, and giant with >9 cm. Usually the size of OMC progressively increases as raised intracranial pressure leads to compensatory cerebrospinal fluid escape into sac with the growth of children. Authors report an interesting case of an 18-month-old female child with extra-gigantic OMC, whose size was almost same since birth, representing the first case of its kind, who underwent successful surgical repair...
October 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28216640/the-ubiquitin-ligase-cullin5-socs2-regulates-ndr1-stk38-stability-and-nf-%C3%AE%C2%BAb-transactivation
#4
Indranil Paul, Tanveer S Batth, Diego Iglesias-Gato, Amna Al-Araimi, Ibrahim Al-Haddabi, Amira Alkharusi, Gunnar Norstedt, Jesper V Olsen, Fahad Zadjali, Amilcar Flores-Morales
SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our unawareness of its protein substrates. We performed a mass spectrometry based proteomic profiling upon SOCS2 depletion and yield quantitative data for ~4200 proteins. Through this screen we identify a novel target of SOCS2, the serine-threonine kinase NDR1. Over-expression of SOCS2 accelerates turnover, while its knockdown stabilizes, endogenous NDR1 protein...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28215037/the-italian-dystonia-registry-rationale-design-and-preliminary-findings
#5
Giovanni Defazio, M Esposito, G Abbruzzese, C L Scaglione, G Fabbrini, G Ferrazzano, S Peluso, R Pellicciari, A F Gigante, G Cossu, R Arca, L Avanzino, F Bono, M R Mazza, L Bertolasi, R Bacchin, R Eleopra, C Lettieri, F Morgante, M C Altavista, L Polidori, R Liguori, S Misceo, G Squintani, M Tinazzi, R Ceravolo, E Unti, L Magistrelli, M Coletti Moja, N Modugno, M Petracca, N Tambasco, M S Cotelli, M Aguggia, A Pisani, M Romano, M Zibetti, A R Bentivoglio, A Albanese, P Girlanda, A Berardelli
The Italian Dystonia Registry is a multicenter data collection system that will prospectively assess the phenomenology and natural history of adult-onset dystonia and will serve as a basis for future etiological, pathophysiological and therapeutic studies. In the first 6 months of activity, 20 movement disorders Italian centres have adhered to the registry and 664 patients have been recruited. Baseline historical information from this cohort provides the first general overview of adult-onset dystonia in Italy...
February 18, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28195215/the-structural-switch-of-nucleotide-free-kinesin
#6
Luyan Cao, Soraya Cantos-Fernandes, Benoît Gigant
Kinesin-1 is an ATP-dependent motor protein that moves towards microtubules (+)-ends. Whereas structures of isolated ADP-kinesin and of complexes with tubulin of apo-kinesin and of ATP-like-kinesin are available, structural data on apo-kinesin-1 in the absence of tubulin are still missing, leaving the role of nucleotide release in the structural cycle unsettled. Here, we identified mutations in the kinesin nucleotide-binding P-loop motif that interfere with ADP binding. These mutations destabilize the P-loop (T87A mutant) or magnesium binding (T92V), highlighting a dual mechanism for nucleotide release...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194009/a-metamorphic-inorganic-framework-that-can-be-switched-between-eight-single-crystalline-states
#7
Caihong Zhan, Jamie M Cameron, David Gabb, Thomas Boyd, Ross S Winter, Laia Vilà-Nadal, Scott G Mitchell, Stefan Glatzel, Joachim Breternitz, Duncan H Gregory, De-Liang Long, Andrew Macdonell, Leroy Cronin
The design of highly flexible framework materials requires organic linkers, whereas inorganic materials are more robust but inflexible. Here, by using linkable inorganic rings made up of tungsten oxide (P8W48O184) building blocks, we synthesized an inorganic single crystal material that can undergo at least eight different crystal-to-crystal transformations, with gigantic crystal volume contraction and expansion changes ranging from -2,170 to +1,720 Å(3) with no reduction in crystallinity. Not only does this material undergo the largest single crystal-to-single crystal volume transformation thus far reported (to the best of our knowledge), the system also shows conformational flexibility while maintaining robustness over several cycles in the reversible uptake and release of guest molecules switching the crystal between different metamorphic states...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28176633/hypothyroidism-and-nephrotic-syndrome-why-when-and-how-to-treat
#8
Francesca Di Mario, Riccardo Pofi, Antonietta Gigante, Laura Rivoli, Edoardo Rosato, Andrea Maria Isidori, Rosario Cianci, Biagio Barbano
Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS). This is a common feature of primary and secondary glomerular diseases and comprises loss of protein in the urine and increased urinary excretion of thyroid hormones and thyroxine-binding globulin. With a normal thyroid reserve, this scenario is associated with the development of subclinical hypothyroidism, with a slight increase in TSH and normal free fractions...
February 7, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28174825/diet-induced-overweight-and-obesity-and-periodontitis-risk-an-application-of-the-parametric-g-formula-in-the-1982-pelotas-birth-cohort
#9
Gustavo G Nascimento, Marco A Peres, Murthy N Mittinty, Karen G Peres, Loc G Do, Bernardo L Horta, Denise P Gigante, Marcos B Corrêa, Flávio F Demarco
No abstract text is available yet for this article.
February 8, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28168104/an-early-geikiid-dicynodont-from-the-tropidostoma-assemblage-zone-late-permian-of-south-africa
#10
Christian F Kammerer, Roger M H Smith
Based on specimens previously identified as Tropidostoma, a new taxon of dicynodont (Bulbasaurus phylloxyron gen. et sp. nov.) from the Karoo Basin of South Africa is described. Bulbasaurus is a medium-sized dicynodont (maximum dorsal skull length 16.0 cm) restricted to the Tropidostoma Assemblage Zone (early Lopingian) of the Beaufort Group. Bulbasaurus can be distinguished from Tropidostoma by an array of characters including the presence of a tall, sharp premaxillary ridge, large, rugose, nearly-confluent nasal bosses, a nasofrontal ridge, massive tusks, robust pterygoids, prominently twisted subtemporal bar, and absence of a distinct postfrontal...
2017: PeerJ
https://www.readbyqxmd.com/read/28165555/nutritional-status-and-intrarenal-arterial-stiffness-in-cardiorenal-syndrome-a-pilot-study
#11
A Gigante, F Di Mario, B Barbano, E Rosato, G Di Lazzaro Giraldi, R Pofi, M L Gasperini, D Amoroso, R Cianci, A Laviano
OBJECTIVE: Cardio-Renal Syndrome (CRS) is a condition, which is more frequently observed in clinical practice. The aim of this study is to explore nutritional status and intrarenal arterial stiffness in patients affected by CRS. PATIENTS AND METHODS: 14 consecutive CRS patients, screened for anthropometry, biochemistry, nutritional and metabolic status underwent renal Doppler ultrasound and whole-body bioimpedance spectroscopy (BIS). RESULTS: We found a positive correlation between phase angle (PA) and CKD-EPI and MDRD (p=0...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28160289/melanopsin-expressing-human-retinal-ganglion-cells-subtypes-distribution-and-intraretinal-connectivity
#12
Jens Hannibal, Anders Tolstrup Christensen, Steffen Heegaard, Jan Fahrenkrug, Jens Folke Kiilgaard
Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin belong to a heterogenic population of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupillary light reflex and sleep/wake cycles. The different functions seem to be associated to different subtypes of melanopsin cells. In rodents, subtype classification has associated subtypes to function. In primate and human retina such classification has so far, not been applied. In the present study using antibodies against N- and C-terminal parts of human melanopsin, confocal microscopy and 3D reconstruction of melanopsin immunoreactive (-ir) RGCs, we applied the criteria used in mouse on human melanopsin-ir RGCs...
February 3, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28125662/serum-fatty-acids-desaturase-activities-and-abdominal-obesity-a-population-based-study-of-60-year-old-men-and-women
#13
Zayed D Alsharari, Ulf Risérus, Karin Leander, Per Sjögren, Axel C Carlsson, Max Vikström, Federica Laguzzi, Bruna Gigante, Tommy Cederholm, Ulf De Faire, Mai-Lis Hellénius, Matti Marklund
Abdominal obesity is a key contributor of metabolic disease. Recent trials suggest that dietary fat quality affects abdominal fat content, where palmitic acid and linoleic acid influence abdominal obesity differently, while effects of n-3 polyunsaturated fatty acids are less studied. Also, fatty acid desaturation may be altered in abdominal obesity. We aimed to investigate cross-sectional associations of serum fatty acids and desaturases with abdominal obesity prevalence in a population-based cohort study. Serum cholesteryl ester fatty acids composition was measured by gas chromatography in 60-year old men (n = 1883) and women (n = 2015)...
2017: PloS One
https://www.readbyqxmd.com/read/28120548/ds6-anticandidal-antibiofilm-peptide-against-candida-tropicalis-and-exhibit-synergy-with-commercial-drug
#14
Kusum Singh, Shashank Shekhar, Yudhishthir Yadav, Immaculata Xess, Sharmistha Dey
Antifungal peptides have gained interest as therapeutic agents in recent years because of increased multidrug resistance against present antifungal drugs. This study designed, synthesized and characterized antifungal activity of a small peptide analogue, DS6. This peptide was designed using the template from the N-terminal part of the antifungal protein, Aspergillus giganteous. DS6 inhibited Candida tropicalis (ATCC 13803), as well as its clinical isolates. DS6 was found to be a fungicidal, killing the fungus very rapidly...
January 25, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28117477/hard-metal-lung-disease-a-case-series
#15
Rafael Futoshi Mizutani, Mário Terra-Filho, Evelise Lima, Carolina Salim Gonçalves Freitas, Rodrigo Caruso Chate, Ronaldo Adib Kairalla, Regiani Carvalho-Oliveira, Ubiratan Paula Santos
Objective: To describe diagnostic and treatment aspects of hard metal lung disease (HMLD) and to review the current literature on the topic. Methods: This was a retrospective study based on the medical records of patients treated at the Occupational Respiratory Diseases Clinic of the Instituto do Coração, in the city of São Paulo, Brazil, between 2010 and 2013. Results: Of 320 patients treated during the study period, 5 (1.56%) were diagnosed with HMLD...
November 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28107992/designing-of-ordered-two-dimensional-gold-nanoparticles-film-for-cocaine-detection-in-human-urine-using-surface-enhanced-raman-spectroscopy
#16
Juan Meng, Xianghu Tang, Binbin Zhou, Qiwen Xie, Liangbao Yang
A novel and rapid method to detect cocaine in human urine has been developed by using self-assembly ordered two dimensional (2D) gold nanoparticles (GNPs) film as surface-enhanced Raman spectroscopy (SERS) substrates. In order to obtain high sensitivity, uniformity, and reproducibility of SERS platform, quasi-spherical, uniform GNPs were firstly synthesis using seed growth method, in which the GNPs have been functionalized with CTAB to form orderly close-packed GNPs film as SERS substrate. Importantly, the high-performance GNPs on solid substrates can produce a high yield of sub-10-nm gaps which can generate gigantic signals enhancement for analytes adsorbed GNPs surface...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28103659/-a-case-of-giant-prostate-carcinoma-effectively-treated-with-external-beam-radiation-therapy
#17
Sohei Kanda, Shintaro Narita, Naoki Komine, Seiichi Kitajima, Misa Yamauchi, Akihiro Sugita, Yutaka Saito, Tomonori Habuchi
We present a case of gigantic prostate tumor in a patient with castration-resistant prostate cancer with successful local control by external-beam radiation therapy. A 71-year-old man was shown to have a prostate specific antigen (PSA)level of 24.5 ng/ml, Gleason 9, cT2N1M1a, prostate adenocarcinoma with an estimated prostate volume of 26.9 g. He achieved a PSA nadir at 4 months after the initial androgen deprivation therapy and was diagnosed with castration-resistant prostate cancer three years later. Eight months after the diagnosis of castration-resistant prostate cancer, he visited our hospital due to urinary retention...
December 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28101876/extraction-of-actionable-information-from-crowdsourced-disaster-data
#18
Rungsun Kiatpanont, Uthai Tanlamai, Prabhas Chongstitvatana
Natural disasters cause enormous damage to countries all over the world. To deal with these common problems, different activities are required for disaster management at each phase of the crisis. There are three groups of activities as follows: (1) make sense of the situation and determine how best to deal with it, (2) deploy the necessary resources, and (3) harmonize as many parties as possible, using the most effective communication channels. Current technological improvements and developments now enable people to act as real-time information sources...
November 2016: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28098943/a-survey-of-the-peptide-profile-in-prato-cheese-as-measured-by-maldi-ms-and-capillary-electrophoresis
#19
Débora Parra Baptista, Francisca Diana da Silva Araújo, Marcos Nogueira Eberlin, Mirna Lúcia Gigante
In this study, we describe the characterization of the peptide profile in commercial Prato cheese by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) and capillary electrophoresis (CE). Ten commercial Prato cheese brands were characterized via their physicochemical composition and subjected to fractionation according to solubility at pH 4.6. The pH 4.6 insoluble fraction was evaluated by CE, whereas MALDI-MS was applied to the fraction soluble at pH 4.6 and in 70% ethanol. CE revealed a characteristic pattern of hydrolysis, with formation of para-κ-casein, hydrolysis of αs1 -casein at the Phe23 - Phe24 bond, and hydrolysis of β-casein...
January 18, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28081126/a-pan-lyssavirus-taqman-real-time-rt-pcr-assay-for-the-detection-of-highly-variable-rabies-virus-and-other-lyssaviruses
#20
Ashutosh Wadhwa, Kimberly Wilkins, Jinxin Gao, Rene Edgar Condori Condori, Crystal M Gigante, Hui Zhao, Xiaoyue Ma, James A Ellison, Lauren Greenberg, Andres Velasco-Villa, Lillian Orciari, Yu Li
Rabies, resulting from infection by Rabies virus (RABV) and related lyssaviruses, is one of the most deadly zoonotic diseases and is responsible for up to 70,000 estimated human deaths worldwide each year. Rapid and accurate laboratory diagnosis of rabies is essential for timely administration of post-exposure prophylaxis in humans and control of the disease in animals. Currently, only the direct fluorescent antibody (DFA) test is recommended for routine rabies diagnosis. Reverse-transcription polymerase chain reaction (RT-PCR) based diagnostic methods have been widely adapted for the diagnosis of other viral pathogens, but there is currently no widely accepted rapid real-time RT-PCR assay for the detection of all lyssaviruses...
January 2017: PLoS Neglected Tropical Diseases
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