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https://www.readbyqxmd.com/read/28726888/a-gigantic-polyoxozirconate-with-visible-photoactivity
#1
Tingting Xu, Xudong Hou, Yang Wang, Jun Zhang, Junxiang Zhang, Bo Liu
We present a gigantic polyoxozirconate nanocluster (Zr18O21(μ2-OH)2(OOCPh)28), involving 6, 7 and 8-coordinated Zr atoms. It exhibits visible light driven photocatalytic activity for H2 evolution. The current results could represent a prelude of polyoxozirconate-based photocatalysis.
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28723385/grey-zone-urinary-incontinence
#2
Andrea Tubaro, Arjun K Nambiar
Providing high-quality evidence in the field of urinary incontinence is difficult because the value of diagnostic tests must be evaluated through the filter of treatment outcome, and surgical treatments include an unavoidable amount of intrinsic variability. The scientific community should be commended for the gigantic effort made over the years to provide evidence upon which proper patient management can be based.
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722322/advanced-methods-for-dose-and-regimen-finding-during-drug-development-summary-of-the-ema-efpia-workshop-on-dose-finding-london-4-5-december-2014
#3
F T Musuamba, E Manolis, N Holford, Sya Cheung, L E Friberg, K Ogungbenro, M Posch, Jwt Yates, S Berry, N Thomas, S Corriol-Rohou, B Bornkamp, F Bretz, A C Hooker, P H Van der Graaf, J F Standing, J Hay, S Cole, V Gigante, K Karlsson, T Dumortier, N Benda, F Serone, S Das, A Brochot, F Ehmann, R Hemmings, I Skottheim Rusten
Inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and postmarketing commitments required by regulatory institutions. In an effort to shift the current paradigm in dose and regimen selection and highlight the availability and usefulness of well-established and regulatory-acceptable methods, the European Medicines Agency (EMA) in collaboration with the European Federation of Pharmaceutical Industries Association (EFPIA) hosted a multistakeholder workshop on dose finding (London 4-5 December 2014)...
July 19, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28716925/symmetry-related-proton-transfer-pathways-in-respiratory-complex-i
#4
Andrea Di Luca, Ana P Gamiz-Hernandez, Ville R I Kaila
Complex I functions as the initial electron acceptor in aerobic respiratory chains of most organisms. This gigantic redox-driven enzyme employs the energy from quinone reduction to pump protons across its complete approximately 200-Å membrane domain, thermodynamically driving synthesis of ATP. Despite recently resolved structures from several species, the molecular mechanism by which complex I catalyzes this long-range proton-coupled electron transfer process, however, still remains unclear. We perform here large-scale classical and quantum molecular simulations to study the function of the proton pump in complex I from Thermus thermophilus The simulations suggest that proton channels are established at symmetry-related locations in four subunits of the membrane domain...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28713720/a-rare-case-of-extra-gigantic-digit-of-sole
#5
Chetan Satish, Subhash Reddy
No abstract text is available yet for this article.
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28705195/peto-s-paradox-how-has-evolution-solved-the-problem-of-cancer-prevention
#6
Marc Tollis, Amy M Boddy, Carlo C Maley
The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto's Paradox. We discuss what is known about Peto's Paradox and provide hints of what is yet to be discovered.
July 13, 2017: BMC Biology
https://www.readbyqxmd.com/read/28694425/insight-into-microtubule-disassembly-by-kinesin-13s-from-the-structure-of-kif2c-bound-to-tubulin
#7
Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang, Benoît Gigant
Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functional construct of the kinesin-13 Kif2C/MCAK in an ATP-like state and bound to the αβ-tubulin heterodimer, a complex mimicking the species that dissociates from microtubule ends during catalytic disassembly. Our results picture how Kif2C stabilizes a curved tubulin conformation. The Kif2C α4-L12-α5 region undergoes a remarkable 25° rotation upon tubulin binding to target the αβ-tubulin hinge...
July 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28693499/conditions-of-gestation-childbirth-and-childhood-associated-with-c-peptide-in-young-adults-in-the-1982-birth-cohort-in-pelotas-rs-brazil
#8
Romildo Luiz Monteiro Andrade, Denise Petrucci Gigante, Isabel Oliveira de Oliveira, Bernardo Lessa Horta
BACKGROUND: The connecting peptide in insulin has been associated with cardiovascular risk and overall mortality in the adult population. However, its early determinants are unknown. Assess the association of exposures during pregnancy, delivery, and childhood with C-peptide among 22-23 years old individuals prospectively followed since birth, in a southern Brazilian city. METHODS: In 1982, all hospital births in the city were identified and those livebirths whose families lived in the urban area were evaluated (n = 5914)...
July 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28691411/kupffer-cell-in-the-immune-activation-and-tolerance-toward-hbv-hcv-infection
#9
REVIEW
Yuan Fangchao, Zhang Wenfeng, Mu Di, Gong Jianping
Kupffer cells(KCs) largely found in the sinusoids are the macrophages which specifically reside in liver. KC is a crucial part of innate immune system, acting as scavenger and phagocyte. KCs and sinusoidal endothelial cells together form the first immune barrier of the portal system. Studies show that KCs can not only maintain homeostasis in immune response, but also facilitate the pathogenesis of type B and type C hepatitis through their antigen-presenting function and secretion of soluble mediators. KCs can express TLRs (Toll-like receptors), FasL, Programmed cell death ligand 1 (PD-L1) and secrete large amount of inflammatory factors to lead to the tolerant state of immune response toward HBV/HCV...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28690926/razanandrongobe-sakalavae-a-gigantic-mesoeucrocodylian-from-the-middle-jurassic-of-madagascar-is-the-oldest-known-notosuchian
#10
Cristiano Dal Sasso, Giovanni Pasini, Guillaume Fleury, Simone Maganuco
Razanandrongobe sakalavae Maganuco, Dal Sasso & Pasini, 2006 is a large predatory archosaur from the Middle Jurassic (Bathonian) of the Mahajanga Basin, NW Madagascar. It was diagnosed on the basis of teeth and a fragmentary maxilla, but its affinities were uncertain. Here we describe new cranial remains (above all, an almost complete right premaxilla and a caudally incomplete left dentary) that greatly improve our knowledge on this enigmatic species and reveal its anatomy to be crocodylomorph. The right premaxilla indicates that the rostrum was deep, wide, and not pointed; it bears five teeth that are sub-vertical and just slightly curved lingually; the mesial teeth are U-shaped in cross-section and have serrated carinae on the lingual side; the aperturae nasi osseae (external bony nares) are confluent and face rostrally; and there is no lateral groove at the premaxillomaxillary suture for reception of a hypertrophied lower caniniform tooth...
2017: PeerJ
https://www.readbyqxmd.com/read/28671477/true-vapor-liquid-solid-process-suppresses-unintentional-carrier-doping-of-single-crystalline-metal-oxide-nanowires
#11
Hiroshi Anzai, Masaru Suzuki, Kazuki Nagashima, Masaki Kanai, Zetao Zhu, Yong He, Mickaël Boudot, Guozhu Zhang, Tsunaki Takahashi, Katsuichi Kanemoto, Takehito Seki, Naoya Shibata, Takeshi Yanagida
Single crystalline nanowires composed of semiconducting metal oxides formed via a vapor-liquid-solid (VLS) process exhibit an electrical conductivity even without an intentional carrier doping, although these stoichiometric metal oxides are ideally insulators. Suppressing this unintentional doping effect has been a challenging issue not only for metal oxide nanowires but also for various nanostructured metal oxides toward their semiconductor applications. Here we demonstrate that a pure VLS crystal growth, which occurs only at liquid-solid (LS) interface, substantially suppresses an unintentional doping of single crystalline SnO2 nanowires...
July 7, 2017: Nano Letters
https://www.readbyqxmd.com/read/28668778/solitary-fibrous-tumour-of-the-pleura-presenting-as-a-giant-intrathoracic-mass
#12
Eleeza Raafat, Deepthi Karunasiri, Nader Kamangar
Solitary fibrous tumours (SFTs) are relatively rare neoplasms thought to originate from the submesothelial connective tissue. SFTs have been described in a variety of sites, including the pleura, orbit, lower respiratory tract, peritoneal cavity and heart. These neoplasms are usually benign, though locally aggressive, and metastatic behaviour has been observed in some cases. We describe a case of a 61-year-old man presenting with weight loss, poor appetite, malaise, worsening dyspnoea on exertion and lower extremity oedema, who was found to have a gigantic-21×21 cm-tumour occupying the entire right hemithorax causing compression and displacement of the mediastinum and liver...
June 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28653481/commentary-on-the-mid3-good-practices-paper
#13
Efthymios Manolis, Jacob Brogren, Susan Cole, Justin Pittaway-Hay, Anna Nordmark, Kristin E Karlsson, Frederike Lentz, Norbert Benda, Gaby Wangorsch, Gerard Pons, Wei Zhao, Valeria Gigante, Francesca Serone, Joseph F Standing, Aris Dokoumetzidis, Juha Vakkilainen, Michiel van den Heuvel, Victor Mangas Sanjuan, Johannes Taminiau, Essam Kerwash, David Khan, Flora Tshinanu Musuamba, Ine Skottheim Rusten
No abstract text is available yet for this article.
June 27, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28650033/chloride-assisted-supramolecular-assembly-of-a-luminescent-gigantic-cluster-ag216s56cl7-c-triple-bond-length-as-m-dash-cph-98-h2o-12-with-pseudo-th-skeleton-and-five-shell-arrangement
#14
Zi-Yi Chen, Dennis Y S Tam, Thomas C W Mak
Using a chloride-assisted supramolecular building-block approach, we have employed the molecular Cl@Agm(C[triple bond, length as m-dash]CPh)n entity in the construction of a gigantic cluster namely [Ag216S56Cl7(C[triple bond, length as m-dash]CPh)98(H2O)12][Ag3(imidazole)(H2O)4](SbF6)2 (1), which contains the largest discrete organometallic cluster investigated by X-ray crystallography. Based on an icosahedral Cl@Ag12 kernel, this spheroidal cluster features an unprecedented five-shell structure Cl@Ag12@S12@Ag32@S44Cl6@Ag172 with idealized Th symmetry...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28649740/human-vs-robots-in-the-discovery-and-crystallization-of-gigantic-polyoxometalates
#15
Lee Cronin, Vasilios Duros, Jonathan Grizou, Weimin Xuan, Zied Hosni, De-Liang Long, Haralampos Miras
The discovery of new gigantic molecules formed by self-assembly using single crystal X-ray crystallography is a challenging endeavor as it combines two contingent events; first is the formation of a new molecule, and second its crystallization. Herein, we constructed a workflow that can be followed manually or by a robot to probe the envelope of both events and employed it in the chemical space of a new polyoxometalate cluster, namely Na6[Mo120Ce6O366H12(H2O)78]·200H2O (1) which has a trigonal-ring type architecture (yield 4...
June 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28634279/in-frame-seven-amino-acid-duplication-in-aip-arose-over-the-last-3000-years-disrupts-protein-interaction-and-stability-and-is-associated-with-gigantism
#16
Roberto Salvatori, Serban Radian, Yoan Diekmann, Donato Iacovazzo, Alessia David, Plamena Gabrovska, Giorgia Grassi, Anna-Marie Bussell, Karen Stals, Astrid Weber, Richard Quinton, Elizabeth C Crowne, Valentina Corazzini, Lou Metherell, Tara Kearney, Daniel Du Plessis, Ajay Kumar Sinha, Atik Baborie, Anne-Lise Lecoq, Philippe Chanson, Olaf Ansorge, Sian Ellard, Peter J Trainer, David Balding, Mark G Thomas, Márta Korbonits
OBJECTIVE: Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor or result from recurrent mutation events. DESIGN AND METHODS: Observational, inferential and experimental study, including: AIP mutation testing; reconstruction of 14 AIP-region (8.3 Mbp) haplotypes; coalescent-based approximate Bayesian estimation of the time to most recent common ancestor (tMRCA) of the derived allele; forward population simulations to estimate current number of allele carriers; proposal of mutation mechanism; protein structure predictions; co-immunoprecipitation and cycloheximide chase experiments...
September 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28623261/epitaxially-stabilized-thin-films-of-%C3%AE%C2%B5-fe2o3-001-grown-on-ysz-100
#17
Luca Corbellini, Christian Lacroix, Catalin Harnagea, Andreas Korinek, Gianluigi A Botton, David Ménard, Alain Pignolet
Epsilon ferrite (ε-Fe2O3) is a metastable phase of iron(III) oxide, intermediate between maghemite and hematite. It has recently attracted interest because of its magnetocrystalline anisotropy, which distinguishes it from the other polymorphs, and results in a gigantic coercive field and a natural ferromagnetic resonance frequency in the THz range. Moreover, it possesses a polar crystal structure, making it a potential ferroelectric, hence a potential multiferroic. Due to the need of size confinement to stabilize the metastable phase, ε-Fe2O3 has been synthesized mainly as nanoparticles...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619679/antiviral-activity-of-1-2-3-triazolo-4-5-d-pyrimidin-7-6h-ones-against-chikungunya-virus-targeting-the-viral-capping-nsp1
#18
Alba Gigante, Asier Gómez-SanJuan, Leen Delang, Changqing Li, Oskía Bueno, Ana-María Gamo, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Etienne Decroly, Bruno Coutard, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez
Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted to humans by Aedes mosquitoes. Since 2005, CHIKV has been spreading worldwide resulting in epidemics in Africa, the Indian Ocean islands, Asia and more recently in the Americas. CHIKV is thus considered as a global health concern. There is no specific vaccine or drug available for the treatment of this incapacitating viral infection. We previously identified 3-aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as selective inhibitors of CHIKV replication and proposed the viral capping enzyme nsP1 as a target...
June 12, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28615709/programmable-deployment-of-tensegrity-structures-by-stimulus-responsive-polymers
#19
Ke Liu, Jiangtao Wu, Glaucio H Paulino, H Jerry Qi
Tensegrity structures with detached struts are naturally suitable for deployable applications, both in terrestrial and outer-space structures, as well as morphing devices. Composed of discontinuous struts and continuous cables, such systems are only structurally stable when self-stress is induced; otherwise, they lose the original geometrical configuration (while keeping the topology) and thus can be tightly packed. We exploit this feature by using stimulus responsive polymers to introduce a paradigm for creating actively deployable 3D structures with complex shapes...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614543/cytopathologic-evaluation-of-patients-submitted-to-radiotherapy-for-uterine-cervix-cancer
#20
Cátia Martins Leite Padilha, Mário Lúcio Cordeiro Araújo, Sergio Augusto Lopes de Souza
Cervical cancer is an important public health problem. Pap smear is the leading strategy of screening programs for cervical cancer worldwide. However, delayed diagnosis leads to more aggressive and less effective treatments. Patients with uterine cervix malignancies who are referred for radiotherapy have advanced-stage disease, which results in high rates of locoregional recurrence. The use of radiotherapy as a treatment for cervical cancer causes morphological changes in neoplastic and non-neoplastic epithelial cells, as well as in stromal cells, which make it difficult to diagnose the residual lesion, resulting in a dilemma in cytopathological routine...
April 2017: Revista da Associação Médica Brasileira
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