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https://www.readbyqxmd.com/read/29145212/does-anaemia-have-major-public-health-importance-in-children-aged-6-59-months-in-the-duggina-fanigo-district-of-wolaita-zone-southern-ethiopia
#1
Yohannes Samuel Tiku, Tefera Chane Mekonnen, Shimelash Bitew Workie, Endale Amare
BACKGROUND: Globally, a large number of children aged 6-59 months are affected by anaemia. In Ethiopia, like other developing countries, more than 40% of children under 5 years are affected by anaemia. Anaemia during infancy and childhood period is associated with poor health and impaired cognitive development, leading to reduced academic achievement and earning potential in their adult life. The aim of this research was to assess whether anaemia remained a major public health problem among children aged 6-59 months or not in Duggina Fanigo District of Wolaita Zone, South Ethiopia in 2016...
November 16, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28836341/effect-of-late-prophylaxis-in-hemophilia-on-joint-status-a-randomized-trial
#2
M J Manco-Johnson, B Lundin, S Funk, C Peterfy, D Raunig, M Werk, C L Kempton, M T Reding, S Goranov, L Gercheva, L Rusen, V Uscatescu, M Pierdominici, S Engelen, J Pocoski, D Walker, W Hong
Essentials High-quality data are lacking on use of prophylaxis in adults with hemophilia and arthropathy. SPINART was a 3-year randomized clinical trial of late/tertiary prophylaxis vs on-demand therapy. Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI. Prophylaxis improves function but must start before joint bleeding onset to prevent arthropathy. SUMMARY: Background Limited data exist on the impact of prophylaxis on adults with severe hemophilia A and pre-existing joint disease...
August 24, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28806864/study-of-physical-function-in-adolescents-with-haemophilia-the-so-fit-study
#3
K Khair, M Holland, M Bladen, A Griffioen, P McLaughlin, S von Mackensen
INTRODUCTION: Contemporary haemophilia care demands Patient-Reported Outcomes. SO-FIT is a UK multi-centre study, assessing self-reported function, health-related quality of life (HRQoL) and joint health in boys with severe haemophilia. METHODS: Subjective physical function (PedHAL, HEP-Test-Q) and HRQoL (Haemo-QoL Short Form [SF]) were assessed alongside joint health using the objective Haemophilia Joint Health Score (HJHS v2.1). Demographic and clinical data were collected...
November 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28783594/antigenic-characterization-of-52-55kda-protein-isolated-from-trypanosoma-evansi-and-its-application-in-detection-of-equine-trypanosomosis
#4
S C Yadav, Ritesh Kumar, Jaideep Kumar, Meetali Singh, B C Bera, Rajender Kumar, U Tatu, Kanika Tehri
Trypanosoma evansi is a haemo-protozoan parasite responsible for the disease surra, an economically important disease of wide range of domestic and wild animals. The present diagnostic methods using soluble antigens have inherent problems like lack of standardized and reproducible antigens, as well as ethical issues. This entails further efforts for search of defined antigenic molecules with satisfying sensitivity and specificity for sero-epidemiology of trypanosomosis. In present investigation, we have identified and purified 52-55kDa immuno-dominant protein cluster in molecular mass ranges by preparatory SDS-PAGE methods from T...
August 1, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28778063/coaxial-electrospun-pcl-gelatin-ma-fibers-as-scaffolds-for-vascular-tissue-engineering
#5
P Coimbra, P Santos, P Alves, Sónia P Miguel, Marco P Carvalho, Kevin D de Sá, I J Correia, P Ferreira
Coaxial electrospinning is a technique that allows the production of nanofibers with a core-shell structure. Such fibers present several advantages as materials for the preparation of scaffolds, namely due to the possibility of combining a core with the desired mechanical properties with a shell prepared from biocompatible materials that will establish proper interactions with the host. Herein, core-shell fibrous meshes, composed of a polycaprolactone (PCL) core and a functionalized gelatin shell, were prepared by coaxial electrospinning and then photocrosslinked under UV light aiming to be used in vascular tissue regeneration...
July 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28743653/a-review-of-arterio-venous-fistulae-creation-in-octogenarians
#6
Jennifer Clarissa Diandra, Zhiwen Joseph Lo, Wei-Wen Ang, Jue Fei Feng, Sriram Narayanan, Glenn Wei Leong Tan, Sadhana Chandrasekar
BACKGROUND: To analyse the outcomes of arterio-venous fistulae (AVF) creation in Octogenarians. METHODS: Retrospective study of 47 AVFs created in patients aged 80 years and above from 2008 to 2014. Patient and AVF characteristics and outcomes were evaluated. Predictors of patency were analysed with multivariate analysis and Kaplan-Meier patency and survival analysis was performed. RESULTS: 47 of 1,259 AVFs created were for Octogenarians (4%)...
July 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28728770/don-t-push-your-luck-educational-family-board-not-bored-game-for-school-age-children-living-with-chronic-conditions
#7
Andrea Kennedy, Lisa Semple, Kerri Alderson, Vanessa Bouskill, Janice Karasevich, Brenda Riske, Sheri van Gunst
PURPOSE: Children who are living with chronic conditions may be supported in self-care through enjoyable active learning and family social processes. This research focused on development and evaluation of "Don't Push Your Luck!", an educational board game designed to inspire family discussion about chronic conditions, and help affected children learn about self-care choices and consequences. DESIGN AND METHODS: Mixed-method research was conducted with families from one outpatient Cystic Fibrosis Clinic and four Hemophilia Treatment Centres in Canada and United States (N=72)...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28429867/health-related-quality-of-life-questionnaires-in-individuals-with-haemophilia-a-systematic-review-of-their-measurement-properties
#8
REVIEW
P F Limperg, C B Terwee, N L Young, V E Price, S C Gouw, M Peters, M A Grootenhuis, V Blanchette, L Haverman
BACKGROUND: The evaluation of health related quality of life (HRQOL) is essential for a full assessment of the influence of an illness on patients' lives. The aim of this paper is to critically appraise and compare the measurement properties of HRQOL questionnaires studied in haemophilia. METHODS: Bibliographic databases (Embase, Medline, Cinahl and PsycInfo) were searched for articles evaluating measurement properties of HRQOL questionnaires in haemophilia. Articles were excluded that did not report HRQOL measurement properties, or when <50% of the study population had haemophilia...
July 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28363552/acacia-gum-polysaccharide-based-hydrogel-wound-dressings-synthesis-characterization-drug-delivery-and-biomedical-properties
#9
Baljit Singh, Sushma Sharma, Abhishek Dhiman
Keeping in view the importance of polysaccharide gums for wound care, in the present article, an attempt has been made to explore antioxidant nature of gum acacia in designing hydrogel wound dressing to improve its wound healing potential. These polymers were prepared by using acacia gum-polyvinylpyrollidone/carbopol and were characterized by (13)C NMR, FTIR, SEM, AFM, cryo-SEM, XRD, TGA, DSC and elemental analysis techniques. Some important biomaterial properties of wound dressings such as wound fluid absorption, haemo-compatibility, bioactive assessment, gaseous/water/microbial permeability, mechanical properties, bio-adhesion, drug release, and histology of wound healing were also determined...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28183609/conjugation-of-poly-ethylene-glycol-to-poly-lactide-based-polyelectrolytes-an-effective-method-to-modulate-cytotoxicity-in-gene-delivery
#10
Xiaoshan Fan, Shan Jiang, Zibiao Li, Xian Jun Loh
Positively charged amphiphilic polymers comprising of poly(N,N-dimethylaminoethyl methacrylate) segments on both sides of a poly(l-lactic acid) segment was conjugated with poly(ethylene glycol) (DMA-PLLA-DMA@PEG). Efficient condensation of plasmid DNA by these polymers was shown. Cell toxicity studies demonstrated that the positively charged polymers with attached PEG exhibited much less cytotoxicity than polymers with no PEG in both HEK293 and Hela cell lines. PEGylation also resulted in polymers with enhanced haemo-compatibility...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27943510/low-dose-prophylaxis-in-tunisian-children-with-haemophilia
#11
E Gouider, L Jouini, M Achour, H Elmahmoudi, K Zahra, W Saied, B Meddeb
INTRODUCTION: Low dose prophylaxis could be recommended in countries with limited resources. AIM: We report our single centre experience in children with haemophilia. PATIENTS: Fifty-five children were included in our study with a weekly median dose of 30 UI kg(-1) given once, twice or thrice a week. Age of initiation of prophylaxis is 5.32 years (0.64-11.44). Outcome assessment used were number of bleeding before and after initiating prophylaxis, haemophilia joint health score (HJHS), functional independence score in haemophilia (FISH) and quality of life with the Haemo-QoL...
January 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27875793/detection-and-quantification-of-aggregatibacter-actinomycetemcomitans-porphyromonas-gingivalis-and-streptococcus-oralis-in-blood-samples-with-different-microbiological-identification-methods-an-in-vitro-study
#12
María José Marin, Nagore Ambrosio, Leire Virto, Pedro Diz, Maximiliano Álvarez, David Herrera, Mariano Sanz, Elena Figuero
BACKGROUND: Culture-based methods (culture broth bottles or lysis methods) have been the standard for detecting bacteremia. More recently, quantitative polymerase chain reaction (qPCR) was proposed as a more sensitive and specific test although none of them has been validated for the identification of periodontal pathogens (fastidious growing bacteria) in blood samples. OBJECTIVE: To compare the ability to detect and quantify Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Streptococcus oralis (alone or in combination) in blood samples with three culture techniques [direct anaerobic culturing (DAC), haemo-culture (BACTEC), and lysis-centrifugation (LC)] and a non-culture dependent approach (qPCR) in an in vitro study...
February 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27778434/optimization-of-home-treatment-in-haemophilia-effects-of-transmural-support-by-a-haemophilia-nurse-on-adherence-and-quality-of-life
#13
MULTICENTER STUDY
J Lock, H Raat, M Peters, M Scholten, M Beijlevelt, R Oostenbrink, F W G Leebeek, H A Moll, M H Cnossen
BACKGROUND: Transmural support by a haemophilia nurse may improve treatment and may empower parents and patients. AIM: To measure the effect of structured home visits by a haemophilia nurse in (parents of) patient on aspects of prophylactic home treatment. METHODS: A multicentre intervention study in two paediatric haemophilia treatment centres was performed. Primary outcome measures were: adherence to prescribed treatment, health-related quality of life and behavioural scores...
November 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27566422/parents-perception-of-quality-of-life-in-their-sons-with-haemophilia
#14
Vaughan K Williams, Georgia Antoniou, Anne Jackson, Andrew Atkins
AIM: Quality of life (QOL) in haemophilia involves both physical and psychological issues. This study was performed to determine parents' perceptions of the QOL of their sons with haemophilia and compare this to their children's own assessment. METHODS: In this study, we used the Haemo-QoL questionnaire for haemophilia, to compare the responses of 22 parents to the responses of their children within the age groups 4-7, 8-12 and 13-16 and also for the severity groups mild versus moderate-severe...
December 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27499983/when-size-matters-changing-opinion-in-the-management-of-pleural-space-the-rise-of-small-bore-pleural-catheters
#15
REVIEW
Pier Luigi Filosso, Alberto Sandri, Francesco Guerrera, Andrea Ferraris, Filippo Marchisio, Giulia Bora, Lorena Costardi, Paolo Solidoro, Enrico Ruffini, Alberto Oliaro
Tube thoracostomy is usually the first step to treat several thoracic/pleural conditions such as pneumothorax, pleural effusions, haemothorax, haemo-pneumothorax and empyema. Today, a wide range of drains is available, ranging from small to large bore ones. Indications for an appropriate selection remains yet matter of debate, especially regarding the use of small bore catheters. Through this paper, we aimed to retrace the improvements of drains through the years and to review the current clinical indications for chest drain placement in pleural/thoracic diseases, comparing the effectiveness of small-bore drains vs...
July 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27495754/organ-pretreatment-with-cytotopic-endothelial-localising-peptides-to-ameliorate-microvascular-thrombosis-perfusion-deficits-in-ex-vivo-renal-haemo-reperfusion-models
#16
Karim Hamaoui, Sally Gowers, Martyn Boutelle, Terry Cook, George Hanna, Ara Darzi, Richard Smith, Anthony Dorling, Vassilios Papalois
BACKGROUND: Hypothermic machine organ perfusion (HMP) offers opportunity to manipulate grafts with pharmacological agents prior to transplantation. Pretreating organs with novel cytotopic anti-coagulant peptides that localise to endothelial cell membranes could ameliorate microvascular thrombotic sequelae posttransplantation. We describe experiments testing Thrombalexin (TLN), a novel cell binding thrombin-inhibitor, using porcine and unused human kidneys in a series of ex-vivo normothermic haemo-reperfusion models...
August 5, 2016: Transplantation
https://www.readbyqxmd.com/read/27352908/improvement-in-health-related-quality-of-life-in-patients-with-haemophilia-b-treated-with-nonacog-beta-pegol-a-new-extended-half-life-recombinant-fix-product
#17
MULTICENTER STUDY
P Chowdary, S Kearney, A Regnault, C S Hoxer, D L Yee
INTRODUCTION: Health-related quality of life (HRQoL) of individuals with haemophilia has greatly improved with the use of factor replacement and routine prophylaxis. AIM: To explore the HRQoL of individuals with haemophilia B treated with nonacog beta pegol, an extended half-life recombinant factor IX, in a single-blind, randomized multinational phase III pivotal trial (paradigm(™) 2) and its open-label extension (paradigm(™) 4). METHODS: In the pivotal trial, adolescents and adults with haemophilia B were allocated to 28-week on-demand treatment or randomized to 52 weeks of prophylaxis with 10 or 40 IU kg(-1) nonacog beta pegol administered every seven days...
July 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27158500/generic-and-disease-specific-quality-of-life-among-youth-and-young-men-with-hemophilia-in-canada
#18
J St-Louis, D J Urajnik, F Ménard, S Cloutier, R J Klaassen, B Ritchie, G E Rivard, M Warner, V Blanchette, N L Young
BACKGROUND: This study was undertaken to explore the longitudinal patterns of health-related quality of life (HRQoL) among youth and young adults with Hemophilia A (HA) over a 3-year period. This report presents the baseline characteristics of the study cohort. METHODS: Males, 14 to 29 years of age, with predominantly severe HA were recruited from six treatment centres in Canada. Subjects completed a comprehensive survey. HRQoL was measured using: the CHO-KLAT2...
2016: BMC Hematology
https://www.readbyqxmd.com/read/27150881/cellulitis-and-bacteremia-due-to-corynebacterium-striatum-identified-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#19
Sho Saito, Ichiro Kawamura, Mika Tsukahara, Keiichi Uemura, Kiyofumi Ohkusu, Hanako Kurai
Corynebacterium striatum has been described as a pathogen in immunocompromised patients; however, correctly identifying Corynebacterium spp. is often difficult, and cases of cellulitis caused by C. striatum are only rarely reported. We herein describe a case of cellulitis and bacteremia due to C. striatum identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Antimicrobial susceptibility testing was performed using the Strepto-Haemo Supplement method, and vancomycin was replaced by a narrow-spectrum oral amoxicillin...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27126976/impact-of-previous-open-renal-surgery-on-the-outcomes-of-subsequent-percutaneous-nephrolithotomy-a-meta-analysis
#20
COMPARATIVE STUDY
Henglong Hu, Yuchao Lu, Lei Cui, Jiaqiao Zhang, Zhenyu Zhao, Baolong Qin, Yufeng Wang, Qing Wang, Shaogang Wang
OBJECTIVE: The aim of this study was to systematically compare the perioperative outcomes of percutaneous nephrolithotomy in patients with or without previous ipsilateral open renal surgery (POS). DESIGN: Systematic searches of the PubMed, Web of Science and Cochrane Library databases were used to identify relevant studies, and, following literature screening and data extraction, a meta-analysis was performed. RESULTS: 17 retrospective cohort studies involving 4833 procedures (4784 patients) were included...
April 28, 2016: BMJ Open
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