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https://www.readbyqxmd.com/read/29219816/nephrotic-syndrome-due-to-lupus-like-glomerulonephritis-in-an-hiv-positive-patient
#1
J S Wiegersma, C F M Franssen, A Diepstra
Lupus nephritis, a well-known complication in systemic lupus erythematosus, is characterised by a proliferative glomerulonephritis or membranous nephropathy along with a full-house immunofluorescence pattern on renal biopsy. There are very few exceptions in which similar histopathological findings are present, but case reports show that an increasing number of HIV-positive patients (mostly black Africans, but also white patients) have HIV-immune complex disease (HIVICK), which can mimic lupus nephritis. Lupus-like HIVICK is treated differently than 'true' lupus nephritis, so distinction is warranted...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29216396/short-term-efficacy-and-safety-of-rituximab-therapy-in-refractory-systemic-lupus-erythematosus-results-from-the-british-isles-lupus-assessment-group-biologics-register
#2
Eoghan M McCarthy, Emily Sutton, Stephanie Nesbit, James White, Ben Parker, David Jayne, Bridget Griffiths, David A Isenberg, Anisur Rahman, Caroline Gordon, David P D'Cruz, Benjamin Rhodes, Peter Lanyon, Edward M Vital, Chee-Seng Yee, Christopher J Edwards, Lee-Suan Teh, Mohammed Akil, Neil J McHugh, Asad Zoma, Ian N Bruce
Objectives: To describe the baseline characteristics of SLE patients requiring biologic therapy in the UK and to explore short term efficacy and infection rates associated with rituximab (RTX) use. Methods: Patients commencing biologic therapy for refractory SLE and who consented to join BILAG-BR were analysed. Baseline characteristics, disease activity (BILAG 2004/SLEDAI-2K) and rates of infection over follow-up were analysed. Response was defined as loss of all A and B BILAG scores to ⩽ 1 B score with no new A/B scores in other organ systems at 6 months...
December 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/29208014/plasma-c4d-as-marker-for-lupus-nephritis-in-systemic-lupus-erythematosus
#3
Myriam Martin, Karolina I Smoląg, Albin Björk, Birgitta Gullstrand, Marcin Okrój, Jonatan Leffler, Andreas Jönsen, Anders A Bengtsson, Anna M Blom
BACKGROUND: In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). METHODS: C4d levels were determined by enzyme-linked immunosorbent assay in plasma samples of patients with established SLE using a novel approach based on detection of a short linear cleavage neoepitope. Cross-sectional associations were studied in 98 patients with SLE with samples taken at lower or higher respective disease activity...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29204758/antiphospholipid-antibodies-steroid-dose-arterial-hypertension-relapses-and-late-onset-predict-organ-damage-in-a-population-of-colombian-patients-with-systemic-lupus-erythematosus
#4
Luis F Pinto-Peñaranda, C Muñoz-Grajales, A F Echeverri Garcia, C J Velásquez-Franco, M A Mesa-Navas, M Zuluaga Quintero, S Herrera-Uribe, J D Márquez-Hernández
Organ damage predicts mortality, increased accrual of detriment, and poor quality of life in systemic lupus erythematosus patients. The objective of this study is to determine the damage-free survival and its predictive factors in a population of Colombian subjects. The method used in this study is the retrospective follow-up of a cohort; damage was measured with SLICC/ACR index. Predictors of impairment were assessed by logistic regression and survival analysis. One hundred sixty-one individuals were included; 28...
December 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29196292/gut-microbiota-in-human-sle-and-a-mouse-model-of-lupus
#5
Xin M Luo, Michael R Edwards, Qinghui Mu, Yang Yu, Miranda D Vieson, Christopher M Reilly, S Ansar Ahmed, Adegbenga A Bankole
Gut microbiota dysbiosis has been observed in a number of autoimmune diseases. However, the role of gut microbiota in systemic lupus erythematosus (SLE), a prototypical autoimmune disease characterized by persistent inflammation in multiple organs of the body, remains elusive. Here we report the dynamics of gut microbiota in a murine lupus model, NZB/W F1, as well as intestinal dysbiosis in a small group of SLE patients with active disease. The composition of gut microbiota changed markedly before and after the onset of lupus disease in NZB/W F1 mice, with higher diversity and increased representation of several bacterial species as lupus progressed from pre-disease to the diseased stage...
December 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29195017/high-health-care-utilization-preceding-diagnosis-of-systemic-lupus-erythematosus-in-youth
#6
Joyce C Chang, David S Mandell, Andrea M Knight
OBJECTIVE: Childhood-onset systemic lupus erythematosus (SLE) is associated with high risk for organ damage, which may be mitigated by early diagnosis and treatment. We characterized health care utilization for youth in the year preceding SLE diagnosis compared to controls. METHODS: Using Clinformatics™ DataMart (OptumInsight, Eden Prairie, MN) de-identified administrative data from 2000 to 2013, we identified 682 youth ages 10-24 years with new-onset SLE (≥3 International Classification of Diseases, Ninth Revision (ICD-9) codes for SLE 710...
December 1, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29193883/economic-evaluation-of-lupus-nephritis-in-the-systemic-lupus-international-collaborating-clinics-inception-cohort-using-a-multistate-model-approach
#7
Megan R W Barber, John G Hanly, Li Su, Murray B Urowitz, Yvan St Pierre, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Sasha Bernatsky, Daniel J Wallace, David A Isenberg, Anisur Rahman, Ellen M Ginzler, Michelle Petri, Ian N Bruce, Paul R Fortin, Dafna D Gladman, Jorge Sanchez-Guerrero, Rosalind Ramsey-Goldman, Munther A Khamashta, Cynthia Aranow, Meggan Mackay, Graciela S Alarcón, Susan Manzi, Ola Nived, Andreas Jönsen, Asad A Zoma, Ronald F van Vollenhoven, Manuel Ramos-Casals, Guillermo Ruiz-Irastorza, S Sam Lim, Kenneth C Kalunian, Murat Inanc, Diane L Kamen, Christine A Peschken, Soren Jacobsen, Anca Askanase, Chris Theriault, Vernon Farewell, Ann E Clarke
OBJECTIVE: Little is known about the long-term costs of lupus nephritis (LN). These were compared between patients with and without LN based on multistate modelling. METHODS: Patients from 32 centres in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis and provided annual data on renal function, hospitalizations, medications, dialysis, and selected procedures. LN was diagnosed by renal biopsy or the American College of Rheumatology classification criteria...
November 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29190882/functional-polymorphisms-in-pre-mir146a-and-pre-mir499-are-associated-with-systemic-lupus-erythematosus-but-not-with-rheumatoid-arthritis-or-graves-disease-in-mexican-patients
#8
Isidro Alemán-Ávila, Mayra Jiménez-Morales, Olga Beltrán-Ramírez, Rosa Elda Barbosa-Cobos, Silvia Jiménez-Morales, Fausto Sánchez-Muñoz, Guillermo Valencia-Pacheco, Luis M Amezcua-Guerra, Yaneli Juárez-Vicuña, Dulce Milagro Razo-Blanco Hernández, María Concepción Aguilera-Cartas, Ricardo F López-Villanueva, Oscar Peralta-Zaragoza, Carlos Tovilla-Zárate, Julian Ramírez-Bello
Recently, different microRNA (miRNA) gene polymorphisms have been evaluated in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Graves' disease (GD). In the present study, we examined three single-nucleotide polymorphisms (SNPs) located in the pre-miR-146a (rs2910164G/C), pre-miR-196a-2 (rs11614913C/T), and pre-miR-499 (rs3746444A/G) genes. Our study population included 900 Mexican patients with RA, SLE, or GD, as well as 486 healthy control individuals with no family history of inflammatory or autoimmune diseases...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29180749/clonal-evolution-and-antigen-recognition-of-anti-nuclear-antibodies-in-acute-systemic-lupus-erythematosus
#9
Shuhei Sakakibara, Takao Arimori, Kazuo Yamashita, Hideyuki Jinzai, Daisuke Motooka, Shota Nakamura, Songling Li, Kazuya Takeda, Jun Katayama, Marwa Ali El Hussien, Masashi Narazaki, Toshio Tanaka, Daron M Standley, Junichi Takagi, Hitoshi Kikutani
The evolutional process of disease-associated autoantibodies in systemic lupus erythematosus (SLE) remains to be established. Here we show intraclonal diversification and affinity maturation of anti-nuclear antibody (ANA)-producing B cells in SLE. We identified a panel of monoclonal ANAs recognizing nuclear antigens, such as double-stranded DNA (dsDNA) and ribonucleoproteins (RNPs) from acute SLE subjects. These ANAs had relatively few, but nonetheless critical mutations. High-throughput immunoglobulin sequencing of blood lymphocytes disclosed the existence of sizable ANA lineages shearing critical mutations intraclonally...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29179258/increased-risk-of-autoimmune-disorders-in-infertile-men-analysis-of-us-claims-data
#10
W D Brubaker, S Li, L C Baker, M L Eisenberg
Aberrations in reproductive fitness may be a harbinger of medical diseases in men. Existing data suggest that female infertility is associated with autoimmune disorders; however, this has not been examined in men. As immune surveillance and hormonal factors can impact male fertility and autoimmunity, we sought to determine the association between male infertility and incident autoimmune disorders. We analyzed subjects from the Truven Health MarketScan claims database from 2001 to 2008. Infertile men were identified through diagnosis and treatment codes...
November 27, 2017: Andrology
https://www.readbyqxmd.com/read/29178890/cytokine-and-autoantibody-clusters-interaction-in-systemic-lupus-erythematosus
#11
Yovana Pacheco, Julián Barahona-Correa, Diana M Monsalve, Yeny Acosta-Ampudia, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Rubén D Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González, Juan-Manuel Anaya
BACKGROUND: Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine...
November 25, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29165796/international-bullous-diseases-group-consensus-on-diagnostic-criteria-for-epidermolysis-bullosa-acquisita
#12
REVIEW
C Prost-Squarcioni, F Caux, E Schmidt, M F Jonkman, S Vassileva, S C Kim, P Iranzo, M Daneshpazhooh, J Terra, J Bauer, J Fairley, R Hall, M Hertl, J S Lehman, B Marinovic, A Patsatsi, D Zillikens, V Werth, D T Woodley, D F Murrell
BACKGROUND: Epidermolysis bullosa acquisita (EBA) is a complex autoimmune bullous disease disease with variable clinical presentations and multiple possible diagnostic tests making an international consensus on diagnosis of EBA needed. OBJECTIVES: To obtain an international consensus on the clinical and diagnostic criteria for EBA. METHODS: The international bullous diseases group (IBDG) met three times to discuss the clinical and diagnostic criteria for EBA...
November 22, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29165607/an-evidence-based-approach-to-pre-pregnancy-counselling-for-patients-with-systemic-lupus-erythematosus
#13
Y K Onno Teng, Edwin O W Bredewold, Ton J Rabelink, Tom W J Huizinga, H C Jeroen Eikenboom, Maarten Limper, Ruth D E Fritsch-Stork, Kitty W M Bloemenkamp, Marieke Sueters
Patients with SLE are often young females of childbearing age and a pregnancy wish in this patient group is common. However, SLE patients are at high risk for adverse pregnancy outcomes that require adequate guidance. It is widely acknowledged that pre-pregnancy counselling is the pivotal first step in the management of SLE patients with a wish to become pregnant. Next, management of these patients is usually multidisciplinary and often requires specific expertise from the different physicians involved. Very recently a EULAR recommendation was published emphasizing the need for adequate preconception counselling and risk stratification...
November 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/29161964/suicidal-ideation-in-systemic-lupus-erythematous-nr2a-gene-polymorphism-clinical-and-psychosocial-factors
#14
R I Buji, N A Abdul Murad, L F Chan, T Maniam, M S Mohd Shahrir, M Rozita, A S Shamsul, R Mohamad Hussain, N Abdullah, R Jamal, N R Nik Jaafar
Background Systemic lupus erythematous (SLE) patients are a high-risk population for suicide. Glutamatergic neurosystem genes have been implicated in the neurobiology of depression in SLE and suicidal behaviour in general. However, the role of glutamate receptor gene polymorphisms in suicidal behaviour among SLE patients remains unclear in the context of established clinical and psychosocial factors. We aimed to investigate the association of NR2A gene polymorphism with suicidal ideation in SLE while accounting for the interaction between clinical and psychosocial factors...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29161471/peer-to-peer-mentoring-for-african-american-women-with-lupus-a-feasibility-pilot
#15
Edith M Williams, J Madison Hyer, Ramakrishnan Viswanathan, Trevor D Faith, Delia Voronca, Mulugeta Gebregzaibher, Jim C Oates, Leonard Egede
OBJECTIVE: To examine the feasibility and potential benefits of peer mentoring to improve the disease self-management and quality of life of individuals with systemic lupus erythematosus (SLE). METHODS: Peer mentors were trained and paired with up to three mentees to receive self-management education and support by telephone over 12 weeks. This study took place at an academic teaching hospital in Charleston, South Carolina. Seven quads consisting of one peer mentor and three mentees were matched based on factors such as age, area of residence, marital and work status...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29157178/compliance-and-persistence-with-hydroxychloroquine-in-south-korean-patients-with-systemic-lupus-erythematosus
#16
S-G Lee, E-K Park, J-H Park, S-M Kweon, Y-K Kim, G-T Kim
We aimed to analyze compliance and persistence with hydroxychloroquine (HCQ) in real practice and identify risk factors for poor adherence in South Korean patients with systemic lupus erythematosus (SLE). This retrospective longitudinal study evaluated 235 SLE patients in whom oral HCQ was newly started from 2002 to 2016 at a tertiary hospital in South Korea. Compliance was assessed using one-year medication possession ratio (MPR) and non-compliance was defined as a one-year MPR < 0.8. Persistence was determined as the time from HCQ treatment initiation to discontinuation without interruption for ≥56 days...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29152675/a-randomized-double-blind-placebo-controlled-trial-of-vitamin-d-supplementation-in-juvenile-onset-systemic-lupus-erythematosus-positive-effect-on-trabecular-microarchitecture-using-hr-pqct
#17
G L Lima, J A Paupitz, N E Aikawa, J C Alvarenga, R M Rodrigues Pereira
In this randomized double-blind placebo-controlled 24-week trial, cholecalciferol supplementation at 50,000 IU/week effectively improved bone microarchitecture parameters in juvenile-onset systemic lupus erythematosus (JoSLE) patients, as assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at tibia site. An increase in the trabecular number and a decrease in the trabecular separation were observed, suggesting that vitamin D supplementation may be recommended for JoSLE patients with its deficiency...
November 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29150407/disease-trends-over-time-and-cd4-ccr5-t-cells-expansion-predict-carotid-atherosclerosis-development-in-patients-with-systemic-lupus-erythematosus
#18
A Baragetti, G A Ramirez, M Magnoni, K Garlaschelli, L Grigore, M Berteotti, I Scotti, E Bozzolo, A Berti, P G Camici, A L Catapano, A A Manfredi, E Ammirati, G D Norata
BACKGROUND AND AIM: Patients with Systemic Lupus Erythematosus (SLE) present increased cardiovascular mortality compared to the general population. Few studies have assessed the long-term development and progression of carotid atherosclerotic plaque in SLE patients. Our aim was to investigate the association of clinical and laboratory markers of disease activity and classical cardiovascular risk factors (CVRF) with carotid atherosclerosis development in SLE patients in a prospective 5-year study...
September 18, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29145701/tnf-antagonists-killing-two-birds-with-one-biologic-stone
#19
EDITORIAL
Joan M Bathon, Jon T Giles, Daniel H Solomon
Forty years have passed since it was first recognized that patients with autoimmune rheumatic disease have an increased risk of fatal and non-fatal cardiovascular (CV) events (1) Although initial reports focused on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), similar findings were verified subsequently in patients with psoriasis (Ps) and/or psoriatic arthritis (PsA) and spondyloarthritis. An early feature of the atherosclerotic lesion is infiltration with inflammatory cells, particularly monocytes/macrophages, and the presence of these cells in mature plaque elevates the risk of plaque rupture and thrombosis (2)...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29145159/potential-link-between-m-6-a-modification-and-systemic-lupus-erythematosus
#20
REVIEW
Lian-Ju Li, Yin-Guang Fan, Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye
The field of m(6)A modification and epitranscriptomics has recently attracted much attention. More methods allowing for precise m(6)A site profiling and location are developed and crucial players of m(6)A modification machinery are increasingly identified. Although some challenges remain, m(6)A modification is found to modulate almost all aspects of RNA metabolism, such as splicing, stability, structure, translation, and export. Thus, m(6)A modification adds a new layer of post-transcriptional gene expression regulation, and it is implicated in T cell response to HIV infection, type I interferon production, and T cell differentiation and homeostasis...
November 13, 2017: Molecular Immunology
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