Dunsheng Liang, Xiaofan Shen, Lu Han, Hao Ren, Tao Zang, Lulu Tan, Zhaoxiang Lu, Xiaoping Liao, Berwin Singh Swami Vetha, Yahong Liu, Chaoqun Zhang, Jian Sun
Curcumin, a natural bioactive polyphenol with diverse molecular targets, is well known for its anti-oxidation and anti-inflammatory potential. However, curcumin exhibits low solubility (<1 µg mL-1 ), poor tissue-targeting ability, and rapid oxidative degradation, resulting in poor bioavailability and stability for inflammatory therapy. Here, poly(diselenide-oxalate-curcumin) nanoparticle (SeOC-NP) with dual-reactive oxygen species (ROS) sensitive chemical moieties (diselenide and peroxalate ester bonds) is fabricated by a one-step synthetic strategy...
March 3, 2024: Advanced Healthcare Materials