keyword
https://read.qxmd.com/read/38489162/polysaccharide-from-pleurotus-tuber-regium-mycelium-improves-dss-induced-colitis-in-mice-by-regulating-inflammatory-cytokines-oxidative-stress-and-gut-microbiota
#21
JOURNAL ARTICLE
Cuiyuan Mo, Ruofan Liu, Zhenhua Yang, Aimin Ma
Pleurotus tuber-regium (PTR) has been proved to have obvious pharmacological properties. In this study, a polysaccharide was extracted from the mycelium of PTR and administered to DSS-induced colitis mice to clarify the protective effect and mechanism of the PTR polysaccharide (PTRP) on colitis. The results showed that PTRP significantly improved the clinical symptoms and intestinal tissue damage caused by colitis and inhibited the secretion of pro-inflammatory cytokines and myeloperoxidase activity, while the levels of oxidative stress factors in mice decreased and the antioxidant capacity increased...
March 15, 2024: Food & Function
https://read.qxmd.com/read/38485738/chicoric-acid-alleviates-colitis-via-targeting-the-gut-microbiota-accompanied-by-maintaining-intestinal-barrier-integrity-and-inhibiting-inflammatory-responses
#22
JOURNAL ARTICLE
Yan Di, Yi Song, Kejia Xu, Qianxu Wang, Li Zhang, Qian Liu, Min Zhang, Xuebo Liu, Yutang Wang
Polyphenols have shown great potential to prevent ulcerative colitis. As a natural plant polyphenol, chicoric acid (CA) has antioxidant and anti-inflammatory properties. This study explored the intervention effects and potential mechanism of CA on dextran sodium sulfate (DSS)-induced colitis mice. The results showed that CA alleviated the symptoms of colitis and maintained the intestinal barrier integrity. CA significantly downregulated the mRNA expression levels of inflammatory factors including IL-6, IL-1β, TNF-α, IFN-γ, COX-2, and iNOS...
March 14, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38463553/robust-reactive-oxygen-species-modulator-hitchhiking-yeast-microcapsules-for-colitis-alleviation-by-trilogically-intestinal-microenvironment-renovation
#23
JOURNAL ARTICLE
Jintao Li, Jian Song, Zhichao Deng, Jian Yang, Xiaoqin Wang, Bowen Gao, Yuanyuan Zhu, Mei Yang, Dingpei Long, Xiaoqin Luo, Mingxin Zhang, Mingzhen Zhang, Runqing Li
Ulcerative colitis (UC) is characterized by chronic inflammatory processes of the intestinal tract of unknown origin. Current treatments lack understanding on how to effectively alleviate oxidative stress, relieve inflammation, as well as modulate gut microbiota for maintaining intestinal homeostasis synchronously. In this study, a novel drug delivery system based on a metal polyphenol network (MPN) was constructed via metal coordination between epigallocatechin gallate (EGCG) and Fe3+ . Curcumin (Cur), an active polyphenolic compound, with distinguished anti-inflammatory activity was assembled and encapsulated into MPN to generate Cur-MPN...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38461332/a-single-agent-fusion-of-human-il-2-and-anti-il-2-antibody-that-selectively-expands-regulatory-t-cells
#24
JOURNAL ARTICLE
Yuan Lin, Xue Wang, Yuhao Qin, Chengpan Wang, Tang Zhou, Long Zhang, Lu Su, Wenming Ren, Cheng Liao
The occurrence of many autoimmune diseases takes root on the disrupted balance among Treg cells, Teff cells, etc. Low-dose interleukin-2 (IL-2) cytokine demonstrates promising clinical efficacy in the expansion of Treg cells and the treatment of autoimmune diseases. However, its clinical application is hindered by the small therapeutic index and short half-life. Previous studies have shown that non-covalent complex of human IL-2 and anti-IL-2 antibody biases cytokine activity towards Treg cells and extends IL-2's half-life...
March 9, 2024: Communications Biology
https://read.qxmd.com/read/38447847/screening-and-characterization-of-an-anti-inflammatory-pectic-polysaccharide-from-cucurbita-moschata-duch
#25
JOURNAL ARTICLE
Linlin Huang, Qi Sun, Quanhong Li, Xin Li
Pectin polysaccharides have demonstrated diverse biological activities, however, the inflammatory potential of pectin polysaccharides extracted from Cucurbita moschata Duch remains unexplored. This study aims to extract, characterize and evaluate the effects of pumpkin pectin polysaccharide on lipopolysaccharide (LPS)-induced inflammatory response in RAW264.7 cells and dextran sulfate sodium (DSS)-induced colitis in mice, along with its underlying mechanism of action. Initially, we extracted three fractions of pectin polysaccharides from pumpkin and screened them for anti-inflammatory activity in LPS-induced macrophages, identifying CMDP-3a as the most potent anti-inflammatory fraction...
March 4, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38445918/somatostatin-alleviates-diversion-colitis-after-fecal-stream-bypass-colostomy-surgeries-in-rats
#26
JOURNAL ARTICLE
Yonghao Chen, Xiaoxi Xie, Yaoyu Guo, Yanni Li, Chong Geng, Xiao Li, Chunhui Wang
BACKGROUND: Diversion colitis (DC) is a prevalent complication of colostomy characterized by intestinal inflammation. This study aimed to investigate the therapeutic potential of somatostatin (SST) in managing DC. METHODS: After establishing a rat DC model, SST was administered via Mini Osmotic Pumps 2001W at a pumping rate of 1.0 μL/h. Various techniques, including hematoxylin and eosin staining, periodic acid-Schiff staining, immunofluorescence staining, and electron microscopy were employed to assess the effects of SST...
March 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38435393/essential-oils-a-systematic-review-on-revolutionizing-health-nutrition-and-omics-for-optimal-well-being
#27
REVIEW
Camila Pezantes-Orellana, Fátima German Bermúdez, Carmen Matías De la Cruz, José Luis Montalvo, Andrea Orellana-Manzano
PURPOSE: Essential oils from various plants have diverse therapeutic properties and are researched extensively. They have applications in medicine, aromatherapy, microbiology, agriculture, livestock, and the food industry, benefiting the population. METHODS: This systematic review followed the PRISMA verification protocol. The study focused on the anti-inflammatory effects, nutraceutical properties, antioxidant and antibacterial activity of essential oils in lemon, orange, cumin, cinnamon, coriander, rosemary, thyme, and parsley...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38431929/dual-ros-sensitive-moieties-conjugate-inhibits-curcumin-oxidative-degradation-for-colitis-precise-therapy
#28
JOURNAL ARTICLE
Dunsheng Liang, Xiaofan Shen, Lu Han, Hao Ren, Tao Zang, Lulu Tan, Zhaoxiang Lu, Xiaoping Liao, Berwin Singh Swami Vetha, Yahong Liu, Chaoqun Zhang, Jian Sun
Curcumin, a natural bioactive polyphenol with diverse molecular targets, is well known for its anti-oxidation and anti-inflammatory potential. However, curcumin exhibits low solubility (<1 µg mL-1 ), poor tissue-targeting ability, and rapid oxidative degradation, resulting in poor bioavailability and stability for inflammatory therapy. Here, poly(diselenide-oxalate-curcumin) nanoparticle (SeOC-NP) with dual-reactive oxygen species (ROS) sensitive chemical moieties (diselenide and peroxalate ester bonds) is fabricated by a one-step synthetic strategy...
March 3, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38425112/ranunculin-protoanemonin-and-anemonin-pharmacological-and-chemical-perspectives
#29
JOURNAL ARTICLE
Betelhem Sirak, Misgana Aragaw, Solomon Tadesse
Ranunculin, a glucoside, serves as a chemotaxonomic marker in Ranunculaceae plants. When these plants are damaged, an enzyme β-glucosidase triggers the conversion of ranunculin into protoanemonin through hydrolysis. Subsequently, protoanemonin undergoes cyclodimerization to form anemonin. The inherent instability of ranunculin and the rapid dimerization of protoanemonin render them unsuitable for use in biological assays. Conversely, anemonin stands out as the optimal molecule for bioassays and demonstrates diverse biological properties, including anti-inflammatory, anti-infective, and anti-oxidant effects...
February 28, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38423807/modified-2-stage-ipaa-has-similar-postoperative-complication-rates-and-functional-outcomes-compared-to-3-stage-ipaa
#30
JOURNAL ARTICLE
E Clement, W Lin, D Shojaei, P Au-Yeung, A Motamedi, P T Phang
INTRODUCTION: Reconstructive ileal-pouch anal anastomosis (IPAA) for ulcerative colitis (UC) is often created in 3-stages: colectomy ​+ ​ileostomy, proctectomy ​+ ​pouch creation with diverting loop ileostomy, then subsequent ileostomy closure. Modified 2-stage IPAA is without pouch diversion, thus avoiding a third operation. This study compares perioperative complications, quality of life (QOL) and functional outcomes of 3- versus modified 2-stage IPAA...
February 24, 2024: American Journal of Surgery
https://read.qxmd.com/read/38423412/banxia-xiexin-decoction-modulates-gut-microbiota-and-gut-microbiota-metabolism-to-alleviate-dss-induced-ulcerative-colitis
#31
JOURNAL ARTICLE
Yuting Luo, Sai Fu, Yuling Liu, Shasha Kong, Qian Liao, Longfei Lin, Hui Li
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia Xiexin decoction (BXD) is a classic traditional Chinese medicine prescription for treating ulcerative colitis (UC). However, its potential mechanism of action is still unclear. AIM OF THE STUDY: Reveal the correlation between the beneficial impacts of BXD on UC and the composition of the gut microbiota. MATERIALS AND METHODS: The major constituents of BXD were identified using the HPLC-DAD technique. An experimental model of UC was induced in male C57BL/6 mice by administering dextran sodium sulfate (DSS)...
February 27, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38417643/ph-responsive-cus-dsf-el-pvp-nanoplatform-alleviates-inflammatory-bowel-disease-in-mice-via-regulating-gut-immunity-and-microbiota
#32
JOURNAL ARTICLE
Jinpeng Yao, Yu Chen, Liang Zhang, Yuancun Cheng, Zheng Chen, Yanhui Zhang, Xiaoyi Zheng, Yanwei Lv, Shige Wang, Zhaoshen Li, Jiulong Zhao
The clinical treatment of inflammatory bowel disease (IBD) is challenging. We developed copper sulfate (CuS)/disulfiram (DSF)/methacrylic acid-ethyl acrylate copolymer (EL)/polyvinylpyrrolidone (PVP) nanoplatform (CuS/DSF/EL/PVP) and evaluated its efficiency for treating IBD. After oral administration, the pH-sensitive EL protected the CuS/DSF/EL/PVP against degradation by acidic gastric juices. Once the colon was reached, EL was dissolved, releasing DSF and Cu2+ . Further, the main in vivo metabolite of DSF can bind to Cu2+ and form copper (II) N, N-diethyldithiocarbamate (CuET), which significantly alleviated acute colitis in mice...
February 26, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38413544/crass-like-phages-from-discovery-in-human-fecal-metagenome-to-application-as-a-microbial-source-tracking-marker
#33
REVIEW
Arun Thachappully Remesh, Rajlakshmi Viswanathan
CrAss-like phages are a diverse group of bacteriophages genetically similar to the prototypical crAssphage (p-crAssphage), which was discovered in the human gut microbiome through a metagenomics approach. It was identified as a ubiquitous and highly abundant bacteriophage group in the gut microbiome. Initial co-occurrence analysis postulated Bacteroides spp. as the prospective bacterial host. Subsequent studies have confirmed multiple host species under Phylum Bacteroidetes and some Firmicutes. Detection of crAss-like phages in sewage-contaminated environmental water and robust correlation with enteric viruses and bacteria has culminated in their adoption as a microbial source tracking (MST) marker...
February 27, 2024: Food and Environmental Virology
https://read.qxmd.com/read/38411865/strain-specific-anti-inflammatory-effects-of-faecalibacterium-prausnitzii-strain-kbl1027-in-koreans
#34
JOURNAL ARTICLE
Boram Seo, Kyungchan Jeon, Woon-Ki Kim, You Jin Jang, Kwang Hyun Cha, GwangPyo Ko
Faecalibacterium prausnitzii is one of the most dominant commensal bacteria in the human gut, and certain anti-inflammatory functions have been attributed to a single microbial anti-inflammatory molecule (MAM). Simultaneously, substantial diversity among F. prausnitzii strains is acknowledged, emphasizing the need for strain-level functional studies aimed at developing innovative probiotics. Here, two distinct F. prausnitzii strains, KBL1026 and KBL1027, were isolated from Korean donors, exhibiting notable differences in the relative abundance of F...
February 27, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38409485/a-comprehensive-guide-to-assess-gut-mycobiome-and-its-role-in-pathogenesis-and-treatment-of-inflammatory-bowel-disease
#35
REVIEW
Amit Yadav, Renu Yadav, Vishal Sharma, Usha Dutta
Inflammatory bowel disease (IBD) is an immune mediated chronic inflammatory disorder of gastrointestinal tract, which has underlying multifactorial pathogenic determinants such as environmental factors, susceptibility genes, gut microbial dysbiosis and a dysregulated immune response. Human gut is a frequent inhabitant of complex microbial ecosystem encompassing bacteria, viruses, parasites, fungi and other microorganisms that have an undisputable role in maintaining balanced homeostasis. All of these microbes interact with immune system and affect human gut physiology either directly or indirectly with interaction of each other...
February 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38393047/epa-and-dha-alleviated-chronic-dextran-sulfate-sodium-exposure-induced-depressive-like-behaviors-in-mice-and-potential-mechanisms-involved
#36
JOURNAL ARTICLE
Xi-Yu Wang, Shu-Sen He, Miao-Miao Zhou, Xiao-Ran Li, Cheng-Cheng Wang, Ying-Cai Zhao, Chang-Hu Xue, Hong-Xia Che
Patients with ulcerative colitis (UC) have higher rates of depression. However, the mechanism of depression development remains unclear. The improvements of EPA and DHA on dextran sulfate sodium (DSS)-induced UC have been verified. Therefore, the present study mainly focused on the effects of EPA and DHA on UC-induced depression in C57BL/6 mice and the possible mechanisms involved. A forced swimming test and tail suspension experiment showed that EPA and DHA significantly improved DSS-induced depressive-like behavior...
January 31, 2024: Marine Drugs
https://read.qxmd.com/read/38392629/the-role-of-methanogenic-archaea-in-inflammatory-bowel-disease-a-review
#37
REVIEW
Agata Anna Cisek, Edyta Szymańska, Tamara Aleksandrzak-Piekarczyk, Bożena Cukrowska
Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacteria, the diversity of archaea seems to be higher in IBD patients compared to healthy subjects, whereas the prevalence and abundance of gut methanogens declines in IBD, especially in ulcerative colitis. To date, studies focusing on methanogens in pediatric IBD are very limited; nevertheless, the preliminary results provide some evidence that methanogens may be influenced by the chronic inflammatory process in IBD...
February 10, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38384110/asiaticoside-ameliorates-dss-induced-colitis-in-mice-by-inhibiting-inflammatory-response-protecting-intestinal-barrier-and-regulating-intestinal-microecology
#38
JOURNAL ARTICLE
Kunjian Liu, Yu Yin, Chong Shi, Chengqiu Yan, Yiwen Zhang, Li Qiu, Shuangyan He, Guofeng Li
Ulcerative colitis (UC) is one of the most prevalent inflammatory bowel diseases and poses a serious threat to human health. Currently, safe and effective preventive measures are unavailable. In this study, the protective effects of asiaticoside (AS) on dextran sodium sulfate (DSS)-induced colitis in mice and the underlying molecular mechanism were investigated. In this experiment, colitis was induced in mice with DSS. Subsequently, the role of AS in colitis and its underlying mechanisms were examined using H&E staining, immunofluorescence staining, western blot, Elisa, FMT, and other assays...
February 21, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38377705/tauroursodeoxycholic-acid-liposome-alleviates-dss-induced-ulcerative-colitis-through-restoring-intestinal-barrier-and-gut-microbiota
#39
JOURNAL ARTICLE
Junke Zhao, Suqi Hao, Yan Chen, Xiaoxing Ye, Pengchao Fang, Haiyan Hu
Ulcerative colitis (UC) is a chronic and progressive inflammatory disease that damages the colonic mucosa and disrupts the intestinal epithelial barrier. The current clinical treatment for UC is mainly chemotherapy, which has the limited effectiveness and severe side effects. It mainly focuses on the treatment of inflammation while neglecting the repair of the intestinal mucosa and the restoration of the microbiota balance. Here, we aimed to address these challenges by using an amphipathic bile acid -tauroursodeoxycholic acid (TUDCA) to replace cholesterol (CHL) in conventional liposomes...
February 12, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38376725/antibiotics-for-inflammatory-bowel-disease-current-status
#40
REVIEW
Daya K Jha, Shubhra Mishra, Usha Dutta, Vishal Sharma
There is abundant literature reporting about the use of antibiotics in inflammatory bowel disease (IBD), but their role in the management of IBD is not entirely clear. Diverse infectious organisms have been implicated in the pathogenesis of Crohn's disease. Also, infections are believed to be a trigger for flares of ulcerative colitis. The benefit of the routine use of antibiotics in IBD is equivocal. However, there are certain situations, where antibiotics have a clear role and evidence of benefit: perianal fistula, intra-abdominal abscesses in Crohn's disease, acute pouchitis and infection-related flares...
February 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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