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Q L Li, J L Liu, J R Wang, X D Jian, B T Kan, Z C Zhang
Objective: To study the therapy of cordyceps-astragalus-salvia miltiorrhiza in treating acute lung injury and pulmonary interstitial fibrosis induced by paraquat poisoning. Methods: All 120 adult Wister male rats were randomly assigned to three groups, the paraquat poisoning group (rats were intragastric administration paraquat 50 mg/kg body weight once at the beginning) , the cordyceps-astragalus-salvia miltiorrhiza therapy group (rats were given cordyceps-astragalus-salvia miltiorrhiza 90 mg/kg body weight intragastric administration half an hour after paraquat was given, then the same dose was given once a day) ; control group (rats were intragastric administration with physiological saline) ...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
Shuqin Sun, Shuo Yang, Min Dai, Xiujuan Jia, Qiyan Wang, Zheng Zhang, Yongjun Mao
BACKGROUND: Apoptosis plays a critical role in the progression of diabetic cardiomyopathy (DC). Astragalus polysaccharides (APS), an extract of astragalus membranaceus (AM), is an effective cardioprotectant. Currently, little is known about the detailed mechanisms underlying cardioprotective effects of APS. The aims of this study were to investigate the potential effects and mechanisms of APS on apoptosis employing a model of high glucose induction of apoptosis in H9C2 cells. METHODS: A model of high glucose induction of H9C2 cell apoptosis was adopted in this research...
June 13, 2017: BMC Complementary and Alternative Medicine
J C Zimmers, M Thomas, L Yang, A Bombarely, M M Mancuso, M F Wojciechowski, J F Smith
Understanding the source of phenotypic variability is a challenge in the biological sciences. Variation in phenotypes is the result of variation in the genetics and environment the organism experiences, but elucidating the relative contribution of these two parameters can pose problems, especially in the field of systematics. Systematists are challenged to classify biological diversity into groups that share common ancestry. Phenotypic variation can be useful to demonstrate common ancestry, but only when the primary contributor to the variation is under strong genetic control, and thus heritable...
June 8, 2017: Molecular Phylogenetics and Evolution
Mei-Mi Zhao, Wen-Wen Lian, Zhuo Li, Dong-Xue Shao, Si-Chong Chen, Xue-Fei Sun, Hui-Yuan Hu, Rui Feng, Feng Guo, Li-Ying Hao
Astragaloside IV (AS-IV) is one of the active ingredients in Astragalus membrananceus (Huangqi), a traditional Chinese medicine. The present study investigated the effects of AS-IV on Ca[Formula: see text] handling in cardiac myocytes to elucidate its possible mechanism in the treatment of cardiac disease. The results showed that AS-IV at 1 and 10[Formula: see text][Formula: see text]M reduced KCl-induced [Ca[Formula: see text]]i increase ([Formula: see text] from 1.33[Formula: see text][Formula: see text][Formula: see text]0...
2017: American Journal of Chinese Medicine
Keqiong Li, Yi Chen, Rong Jiang, Dilong Chen, Hong Wang, Wei Xiong, Danyang Li, Zehong Liu, Xiaopeng Li, Jing Li, Ke Yuan
3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranosyl-cycloastragenol, or Astragaloside IV (AST), is one of the major active ingredients isolated from Astragalus membranaceous with distinct pharmacological effects, and possesses anti-inflammatory, immunoregulatory and antifibrotic properties. However, the effects of AST on allergic rhinitis remain to be elucidated. The present study aimed to examine the effects of AST on immunoglobulin (Ig) E‑mediated allergic reactions in vivo, by using a mouse model of allergic rhinitis established via repetitive sensitization and intranasal challenge with ovalbumin (OVA)...
June 6, 2017: Molecular Medicine Reports
Erping Xu, Shuo Tian, Mingsan Miao, Xiao Cheng
Our purpose is to study the effect of different component ratio of Astragalus Total Saponins (ATS) and Verbena Total Glycosides (VTG) on the cerebral infarction area and the serum biochemical indicators in the focal cerebral ischemia-reperfusion rat model. Compared with the model group, different component ratio of ATS and VTG could significantly improve the neurological deficit scores to the focal cerebral ischemia-reperfusion rat model, and the group of 7:3, 6:4, 5:5 got the best results; it could reduce the mortality of rat model to a certain extent, and the group of 5:5 group got the best results; it can significantly reduce the cerebral infarction area, and the group of 7:3, 5:5, 4:6 got the best results; it could significantly reduce the content of TNF-α, and the group of 8:2, 6:4 got the best results; it could significantly reduce the content of NO, and the group of 7:3, 5:5 got the best results; it could significantly increase the content of SOD, and the group of 6:4, 5:5 got the best results...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Xiaoli Yan, Xiao Li, Mingsan Miao
Through the study of the effect of different ratio of Astragalus Total Saponins (ATS) and curcumin on Diabetes Mellitu (DM) model rats, we want to improve the screening model of the distribution ratio in Chinese Medicine, screening out the optimal proportion of the prevention and control of DM. By injecting streptozotocin (STZ) in the tail vein of rats to induct the DM rats model, we measured the dynamic change, insulin and insulin antibody (IAA) levels, glycosylated serum protein (GSP) content, lipid metabolism and the changes of renal pathology in DM model rats...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Fanxin Meng, Panju Xu, Xue Wang, Yu Huang, Liyan Wu, Yiling Chen, Lirong Teng, Di Wang
Aims: Sarcodon imbricatus, an edible fungus, is widely used in Asian medicine because of its significant pharmacological activities. In the present study, we investigated the immunomodulatory effects of polysaccharide-enriched S. imbricatus extracts (SP) in cyclophosphamide (CTX)-induced immunosuppressed mice. Results: Astragalus polysaccharide (AP) was used as a positive control. Compared with CTX-induced immunosuppressed mice, thirty-day SP treatment strongly enhanced the organ indexes of spleen and thymus and suppressed hind paw swelling...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Jungbin Song, Sung Hyun Lee, Donghun Lee, Hocheol Kim
Astragalus extract mixture HT042 is a standardized multiherbal mixture comprising Astragalus membranaceus, Eleutherococcus senticosus, and Phlomis umbrosa, which has proven to promote children's height growth. The aim of this study was to investigate the effects of HT042 on longitudinal bone growth, bone mass, and bone microstructure in growing rats using a high-resolution microcomputed tomography system. Four-week-old female rats were fed an HT042-containing diet for 2 weeks. Tibial length was measured at baseline and weekly in vivo...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Bin Ke, Xiao Ke, Xuesi Wan, Yubin Yang, Yingjuan Huang, Jian Qin, Chengheng Hu, Lin Shi
Insulin resistance is associated with obesity and type 2 diabetes. The aim of this study was to explore the mechanism of how Astragalus Polysaccharides (APS) improves insulin resistance in 3T3-L1 adipocytes. A cell culture model of insulin resistance was established in mature 3T3-L1 adipocytes by treating them with TNF-α, high glucose and insulin. Glucose uptake levels were detected in each group. To determine the mechanism by which APS improves insulin resistance in 3T3-L1 adipocytes, qRT-PCR was used to detect the expression of miR-721, and Western blots were used to detect the expression or activity of PPAR-γ, PAKT, PI3K, AKT, and GLUT4...
2017: American Journal of Translational Research
Ai-Ping Li, Zhen-Yu Li, Ting-Li Qu, Xue-Mei Qin, Guan-Hua DU
Astragali Radix (AR) is one of the most popular herbal medicines in traditional Chinese medicine (TCM). Wild AR is believed to be of high quality, and substitution with cultivated AR is frequently encountered in the market. In the present study, two types of ARs (wild and cultivated) from Astragalus membranaceus (Fisch.) Bge. and A. membranaceus var. mongholicus (Bge.) Hsiao, growing in different regions of China, were analyzed by NMR profiling coupled with multivariate analysis. Results showed that both could be differentiated successfully and cultivation patterns or growing years might have greater impact on the metabolite compositions than the variety; the metabolites responsible for the separation were identified...
May 2017: Chinese Journal of Natural Medicines
Jun Lu, Quan-Yi Wang, Yang Zhou, Xiao-Chun Lu, Yong-Hui Liu, Yan Wu, Qiao Guo, Yun-Tian Ma, Yi-Qun Tang
BACKGROUND: Astragaloside Ⅳ (ASG-Ⅳ, (Fig. 1) is the most active component of Chinese sp. Astragalus membranaceus Bunge (Fabaceae) that has showed antioxidant, antiapoptotic and antiviral activities among others. It is reported to play an important role in cardiac fibrosis (CF), but the mechanism remains unclear. PURPOSE: To investigate the mechanism of ASG-Ⅳ on inhibiting myocardial fibrosis induced by hypoxia. STUDY DESIGN: We studied the relationship between anti-fibrotic effect of ASG-Ⅳ and transient receptor potential cation channel, subfamily M, member 7 (TRPM7) by in vivo and in vitro experiments...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Shengru Wu, Yulong Li, Si Chen, Saisai Liang, Xiaochun Ren, Wei Guo, Qingzhu Sun, Xiaojun Yang
Astragalus Polysaccharide (APS), as the main active ingredient of Astragalus membranaceus, has extensive biological activities related to immune, metabolic, and anti-oxidative regulatory processes. Previous studies have proven that piRNAs could play important roles in genital gland. This study aimed to identify the differentially expressed piRNAs in chicken testes in response to dietary APS supplements and further evaluate the roles of these piRNAs related to the effect of dietary APS supplements on testicular changes...
May 20, 2017: International Journal of Biological Macromolecules
Hua-Sheng Peng, Jun Wang, He-Ting Zhang, Hai-Yan Duan, Xiao-Mei Xie, Ling Zhang, Ming-En Cheng, Dai-Yin Peng
BACKGROUND: The content of medicinal bioactive constituents in huangqi is affected by plant age. In this study, we devised a quick and convenient method for determining the age of huangqi, which was cultivated in Hunyuan County (Shanxi Province). METHODS: 1, 2, 3, 4, 5, 8, 10 growth years huangqi had 38 samples, all samples were collected separately. The growth rings in these samples were observed after making paraffin section and freehand-section. The relationship between growth rings and its growth years was analyzed by SPSS 19...
2017: Chinese Medicine
Jin-Ni Hong, Wei-Wei Li, Lin-Lin Wang, Hao Guo, Yong Jiang, Yun-Jia Gao, Peng-Fei Tu, Xue-Mei Wang
BACKGROUND: Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms...
2017: Chinese Medicine
Yao-Wu Fu, Bin Wang, Qi-Zhong Zhang, De-Hai Xu, De-Jie Lin, Xing-Ya Yang, Shu-Qun Zhu, Jing-Yang Pan, Qian Deng, Yan-Meng Liu, Sheng-Yu Zhou
Dactylogyrus ctenopharyngodonid and Ichthyophthirius multifiliis are two important ectoparasites of freshwater fish. Co-infection by the two parasites leads to high fish mortality and results in heavy economic losses. This study aimed to evaluate the efficacy of medicated feed and a ginger extract bath against D. ctenopharyngodonid and I. multifiliis on grass carp and investigate the hematological response of grass carp co-infected by the two parasites. These results demonstrated that red blood cell (RBC) and thrombocyte percentage among leucocytes significantly decreased after grass carp were co-infected by D...
July 2017: Parasitology Research
Lin-Bo Yuan, Chun-Yan Hua, Sheng Gao, Ya-Ling Yin, Mao Dai, Han-Yan Meng, Piao-Piao Li, Zhong-Xin Yang, Qing-Hua Hu
Astragalus polysaccharides (APS) have been shown to possess a variety of biological activities including anti-oxidant and anti-inflammation functions in a number of diseases. However, their function in pulmonary arterial hypertension (PAH) is still unknown. Rats received APS (200[Formula: see text]mg/kg once two days) for 2 weeks after being injected with monocrotaline (MCT; 60[Formula: see text]mg/kg). The pulmonary hemodynamic index, right ventricular hypertrophy, and lung morphological features of the rat models were examined, as well as the NO/eNOS ratio of wet lung and dry lung weight and MPO...
May 18, 2017: American Journal of Chinese Medicine
Ruili Zhang, Qun Yu, Guangliang Shi, Rui Liu, Weiqian Zhang, Xia Zhao, Guangxing Li, Ming Ge
No abstract text is available yet for this article.
May 10, 2017: BMC Veterinary Research
Ronghui Han, Futian Tang, Meili Lu, Chonghua Xu, Jin Hu, Meng Mei, Hongxin Wang
Endothelial dysfunction caused by reactive oxygen species (ROS) has been implicated in numerous cardiovascular diseases. Astragalus polysaccharide (APS), an important bioactive component extracted from the Chinese herb Astragalus membranaceus, has been widely used for the treatment of cardiovascular disease. The present study aimed to investigate the effects of APS on hydrogen peroxide (H2O2)‑induced human umbilical vein endothelial cell (HUVEC) injury. Following treatment with 400 µM H2O2 for 24 h, cell viability was decreased and apoptosis was increased...
June 2017: Molecular Medicine Reports
Mohammed Hamid, Dandan Liu, Yassin Abdulrahim, Yunhuan Liu, Gang Qian, Alamzeb Khan, Fang Gan, Kehe Huang
Selenizing Astragalus polysaccharides (sAPS) were prepared by nitric acid-sodium selenite method. Effect of sAPS on carbon tetrachloride (CCl4)-induced liver injury and the underlying mechanisms were investigated in the rat. Forty male Wistar rats were divided into five equal groups as follows: control group; CCl4 group; CCl4+Astragalus polysaccharides group; CCl4+sodium selenite group and CCl4+selenizing Astragalus polysaccharides group. The results showed that sAPS significantly decreased the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase in the serum, malondialdehyde and hydroxyproline content in liver (P<0...
May 2, 2017: Research in Veterinary Science
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