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Yaling Li, Yun Ye, Hongyan Chen
Astragaloside IV (AS-IV), the major active component of Astragalus membranaceus, has shown attractive anticancer effects in certain cancers. However, the roles and action mechanisms of AS-IV in hepatocellular carcinoma (HCC) are largely unclear. Long noncoding RNAs (lncRNAs) are recently revealed to have crucial roles in HCC initiation and progression, but whether lncRNAs participate in the anticancer roles of AS-IV are unknown. In this study, we demonstrated that AS-IV significantly downregulated lncRNA-ATB expression in a dose- and time-dependent manner in HCC cells...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Debin Liu, Lei Chen, Jianye Zhao, Kang Cui
Astragalus polysaccharides (ASP) is extracted from Astragalus, and is the main active ingredient of Astragalus membranaceus. The purpose of this study was to investigate the protective effect of ASP on rat cardiomyocytes damage induced by myocardial ischemia and reperfusion injury (MVRI) and isoprenaline(ISO) in vivo and in vitro. The model of cardiomyocytes damage was induced using MVRI in a rat in vivo and also using ISO in cell. After ASP intervention, the protective effect of ASP on cardiomyocytes was evaluated by animal experimental and cell experimental...
January 9, 2018: International Journal of Biological Macromolecules
Dan Xie, Yu Wu, Jia-Wei Xiao, Zheng-Xin Xie, Yong-Xin Chen, Wen-Qi He, Dai-Gui Zhang
In this paper, we make a report on new records of medicinal plants in Hubei, which include one newly recorded genera and seven newly recorded species and a newly recorded variety. The newly recorded genera is Anoectochilus and its corresponding species is Anoectochilus roxburghii; These newly recorded species are Euphorbia micractina, Astragalus wulingensis, Blumea megacephala, Potentilla saundersiana, Blumea formosana, Lycoris houdyshelii and Colocasia gigantea ; The newly recorded variety is Neottia puberula var...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Tao Nie, Shiting Zhao, Liufeng Mao, Yiting Yang, Wei Sun, Xiaoliang Lin, Shuo Liu, Kuai Li, Yirong Sun, Peng Li, Zhiguang Zhou, Shaoqiang Lin, Xiaoyan Hui, Aimin Xu, Chung Wah Ma, Yong Xu, Cunchuan Wang, P Rod Dunbar, Donghai Wu
BACKGROUND AND PURPOSE: Increasing energy expenditure through adipocyte thermogenesis is generally accepted as a promising strategy to mitigate obesity and its related diseases, however, few effective and safe agents are available clinically that promote adipocyte thermogenesis. In this study, 20 traditional Chinese herbal medicines were screened to examine whether they induced adipocyte thermogenesis. EXPERIMENTAL APPROACH: The effects of Chinese herbal medicines or indicated components from Astragalus membranaceus on adipocyte thermogenesis were analyzed by qPCR...
January 7, 2018: British Journal of Pharmacology
Chung-Chia Chen, Ling-Chuan Chang, Chun-Hsu Yao, Yuan-Man Hsu, Jia-Horng Lin, Tse-Yen Yang, Yung-Hsiang Chen, Yueh-Sheng Chen
Astragalus membranaceus (AM) is one of 50 fundamental herbs in traditional Chinese medicine. Previous studies have shown that AM extract can be a potential nerve growth-promoting factor, being beneficial for the growth of peripheral nerve axons. We further investigated the effects of AM extract on regeneration in a rat sciatic nerve transection model. Rats were divided into three groups ([Formula: see text]): normal saline (intraperitoneal) as the control, and 1.5[Formula: see text]g/kg or 3.0[Formula: see text]g/kg of AM extract (every other day for four weeks), respectively...
January 3, 2018: American Journal of Chinese Medicine
An-Jun Liu, Juan Yu, Hai-Yu Ji, Hong-Cui Zhang, Yan Zhang, Hui-Ping Liu
The polysaccharides of Astragalus membranaceus have received extensive study and attention, but there have been few reports on the extraction of these polysaccharides using cold water (4 °C). In this study, we fractionated a novel cold-water-soluble polysaccharide (cAMPs-1A) from Astragalus membranaceus with a 92.00% carbohydrate content using a DEAE-cellulose 52 anion exchange column and a Sephadex G-100 column. Our UV, Fourier-transform infrared spectroscopy (FTIR), high-performance gel permeation chromatography, and ion chromatography analysis results indicated the monosaccharide composition of cAMPs-1A with 1...
December 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Zahra Bahaeddin, Asal Yans, Fariba Khodagholi, Shamim Sahranavard
Allium hirtifolium Boiss and Astragalus hamosus L. are mentioned in Iranian traditional medicine ‎documentation as therapy for a kind of dementia with the features and symptoms similar to those ‎of Alzheimer's disease (AD). In the present study, the effects of these herbs on neuro-‎inflammation and memory have been evaluated as new therapies in amyloid beta (Aβ) induced ‎memory impairment model. Separate groups of rats were fed with A. hirtifolium or A. hamosus ‎extract (both 100 mg/kg/day) started one week before stereotaxic surgery to 24 hours before ‎behavioral ‎testing (totally, for 16 successive days)...
December 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Yung-Cheng Huang, Huey-Jen Tsay, Mei-Kuang Lu, Chien-Hung Lin, Chih-Wen Yeh, Hui-Kang Liu, Young-Ji Shiao
Astragalus membranaceus is commonly used in traditional Chinese medicine for strengthening the host defense system. Astragalus membranaceus-polysaccharides is an effective component with various important bioactivities, such as immunomodulation, antioxidant, anti-diabetes, anti-inflammation and neuroprotection. In the present study, we determine the effects of Astragalus membranaceus-polysaccharides on metabolically stressed transgenic mice in order to develop this macromolecules for treatment of sporadic Alzheimer's disease, a neurodegenerative disease with metabolic risk factors...
December 18, 2017: International Journal of Molecular Sciences
Hui Liao, Ling Hu, Xingnuo Cheng, Xiaocheng Wang, Jiarui Li, Linda Banbury, Rongshan Li
Objective: To investigate the correlation between the clinical effects of Huangqi (Astragalus membranaceus) on different stages of diabetic nephropathy (DN) and the pharmacological effect of Huangqi on the activity of inducible nitric oxide synthase (iNOS) in macrophages in different states. Methods: The PubMed, China National Knowledge Infrastructure, and Wanfang databases were searched. Clinical data was sourced from papers on treatment of different stages of DN with Huangqi, and pharmacological data was from papers on the effects of Huangqi on the iNOS activity of macrophages in a resting or an activated state...
2017: Journal of Immunology Research
Merilin Al Sharif, Petko Alov, Antonia Diukendjieva, Vessela Vitcheva, Rumyana Simeonova, Ilina Krasteva, Aleksandar Shkondrov, Ivanka Tsakovska, Ilza Pajeva
The metabolic syndrome, which includes hypertension, type 2 diabetes (T2D) and obesity, has reached an epidemic-like scale. Saponins and sapogenins are considered as valuable natural products for ameliorating this pathology, possibly through the nuclear receptor PPARγ activation. The aims of this study were: to look for in vivo antidiabetic effects of a purified saponins' mixture (PSM) from Astragalus corniculatus Bieb; to reveal by in silico methods the molecular determinants of PPARγ partial agonism, and to investigate the potential PPARγ participation in the PSM effects...
December 13, 2017: Food and Chemical Toxicology
Magdalena Kondeva-Burdina, Aleksandar Shkondrov, Rumyana Simeonova, Vessela Vitcheva, Ilina Krasteva, Iliana Ionkova
The aim of the current study was to evaluate the effect of a defatted extract (EAS) and three flavonoids, isolated from Astragalus spruneri Boiss. (Fabaceae) using in vitro/in vivo models of liver injury. The EAS was characterized by HPLC and flavonoids (14 mg/g dw) and saponins (8 mg/g dw) were proved. The flavonoids (ASF1, ASF3 and ASF5) were isolated from the same extract and partially identified by LC-MS. In in vitro models of non-enzyme induced (Fe2+/AA) lipid peroxidation in isolated liver microsomes and CCl4-induced metabolic bioactivation and t-BuOOH-induced oxidative stress in isolated rat hepatocytes, both EAS and the flavonoids exerted similar to silybin (positive control) an antioxidant and cytoprotective activity, discerned by decreased MDA production in the microsomes and by preserved cell viability and GSH levels as well as by decreased LDH activity and MDA quantity in isolated rat hepatocytes...
December 13, 2017: Food and Chemical Toxicology
Mingmin Tian, Huang Huang
RATIONALE: Multiple myeloma (MM) is a hematologic malignancy characterized by proliferation of clonal plasma cells in the bone marrow. The median survival has increased to 6 years in recent years. But MM remains incurable. Some studies about the effects of Chinese herb medicine on MM have been carried out. Long survival in MM patients through Traditional Chinese Medicine (TCM) therapies has been reported rarely before. PATIENT CONCERNS: We report a case of a female patient who was diagnosed with MM in 2000 at the age of 49...
December 2017: Medicine (Baltimore)
Sayed Mosayeb Mahdavi, Mahdieh Asadi, Malihe Latifi
A new species of the genus Tenuipalpoides (Tetranychidae: Tenuipalpoidini), Tenuipalpoides iraniensis sp. nov. is described and illustrated based on females and deutonymphs collected from Astragalus spp. (Leguminoseae) in Southern Iran (Hormozgan Province). This is the fifth report of this genus for the world and the first report of the tribe Tenuipalpoidini from Iran. The deutonymph of this genus is described for the first time and a key to the species of Tenuipalpoidini of the world is also provided.
October 3, 2017: Zootaxa
Hualiang Jin, Limin Wang, Bei Li, Cui Cai, Jian Ye, Junbo Xia, Shenglin Ma
Astragaloside IV (AS-IV), a main active constituent of Astragalus membranaceus, has been confirmed to have antiasthmatic effects. However, it remained unclear whether the beneficial effects of AS-IV on asthma were attributed to the mTOR inhibition; this issue was the focus of the present work. BALB/c mice were sensitized and challenged with ovalbumin followed with 3 weeks of rest/recovery and then reexposure to ovalbumin. AS-IV was administrated during the time of rest and reexposure. The characteristic features of allergic asthma, including airway hyperreactivity, histopathology, cytokines (IL-4, IL-5, IL-13, IL-17, and INF-γ), and CD4+CD25+Foxp3+Treg cells in bronchoalveolar lavage fluid (BALF), and downstream proteins of mTORC1/2 signaling were examined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Jieli Fu, Qiangzhen Yang, Yuhua Li, Peifei Li, Lirui Wang, Xinhong Li
Numerous studies have shown that Astragalus polysaccharide (APS) has strong antioxidant effects and high practical value for preserving semen at low temperatures in vitro. However, to date, little attention has been paid to the precise mechanism of APS in sperm preservation at 4 °C. Thus, to gain further insight into the protective effects of APS, the present study was performed to assess the changes in sperm quality parameters, antioxidant capacity, ATP content and protein phosphorylation levels. Here, we demonstrated that supplementation with APS could effectively preserve boar sperm quality parameters such as sperm motility, acrosome integrity and mitochondrial membrane potential...
December 12, 2017: Journal of Cellular Physiology
Chao-Yan Wu, Yuan Ke, Yi-Fei Zeng, Ying-Wen Zhang, Hai-Jun Yu
Background: We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles in genesis, growth, development and metastasis of cancer. NF-κB is also involved in the development of treatment resistance in tumors. Here we investigated the antitumor activity of APS in human non-small cell lung cells (A549 and NCI-H358) and the related mechanisms of action...
2017: Cancer Cell International
Yongxia Guo, Qiang Zhang, Zonghui Zuo, Jun Chu, Hongzhi Xiao, M Tariq Javed, Cheng He
Protocatechuic acid (PCA) is an antiviral agent against Avian Influenza virus (AIV) and Infectious Bursal Disease (IBD) virus but its antiviral mechanism is unknown. In this study, we evaluated the humoral and cellular responses to PCA in specific pathogen-free (SPF) chickens. One hundred forty 35-day-old SPF chickens were randomly divided into 7 groups. The birds were inoculated with the commercial, attenuated Newcastle Disease Virus (NDV) vaccine and then received orally with 10, 20 or 40 mg/kg body weight of PCA for 21 days...
December 4, 2017: Microbial Pathogenesis
Dandan Liu, Jing Xu, Gang Qian, Mohammed Hamid, Fang Gan, Xingxiang Chen, Kehe Huang
Our previous studies have shown that oxidative stress could promote the porcine circovirus type 2 (PCV2) replication, and astragalus polysaccharide (APS)/selenium could suppress PCV2 replication. However, whether selenizing astragalus polysaccharide (sAPS) provides protection against oxidative stress-induced PCV2 replication promotion and the mechanism involved remain unclear. The present study aimed to explore the mechanism of the PCV2 replication promotion induced by oxidative stress and a novel pharmacotherapeutic approach involving the regulation of autophagy of sAPS...
December 4, 2017: International Journal of Biological Macromolecules
Yao Kong, Xiangkun Li, Na Zhang, Yu Miao, Haiyan Feng, Tao Wu, Zhihong Cheng
A new agar-free bioautographic assay for xanthine oxidase (XO) inhibitors and superoxide scavengers on TLC layers was developed and validated. Compared to the first version of TLC bioautographic agar overlay method, our bioautographic assay greatly improved the sensitivity and quantification ability. The limit of detection (LOD) of this assay was 0.017ng for allopurinol. Quantitative estimation of XO inhibitors and superoxide scavengers was achieved by densitometry scanning, expressed as allopurinol equivalents in millimoles on a per sample weight basis...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
Hui Yan, Jian Bo Xie, Zhao Jun Ji, Na Yuan, Chang Fu Tian, Shou Kun Ji, Zhong Yu Wu, Liang Zhong, Wen Xin Chen, Zheng Lin Du, En Tao Wang, Wen Feng Chen
Mesorhizobium species are the main microsymbionts associated with the medicinal or sand-fixation plants Astragalus membranaceus and Caragana intermedia (AC) in temperate regions of China, while all the Mesorhizobium strains isolated from each of these plants could nodulate both of them. However, Rhizobium yanglingense strain CCBAU01603 could nodulate AC plants and it's a high efficiency symbiotic and competitive strain with Caragana. Therefore, the common features shared by these symbiotic rhizobia in genera of Mesorhizobium and Rhizobium still remained undiscovered...
2017: Frontiers in Microbiology
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