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Astragalus

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https://www.readbyqxmd.com/read/28071725/astragalus-polysaccharides-attenuate-pcv2-infection-by-inhibiting-endoplasmic-reticulum-stress-in-vivo-and-in-vitro
#1
Hongxia Xue, Fang Gan, Gang Qian, Junfa Hu, Shu Hao, Jing Xu, Xingxiang Chen, Kehe Huang
This study explored the effects of Astragalus polysaccharide (APS) on porcine circovirus type 2 (PCV2) infections and its mechanism in vivo and vitro. First, fifty 2-week-old mice were randomly divided into five groups: a group without PCV2 infection and groups with PCV2 infections at 0, 100, 200 or 400 mg/kg APS treatments. The trial lasted for 28 days. The results showed that APS treatments at 200 and 400 mg/kg reduced the pathological injury of tissues, inhibited PCV2 infection and decreased glucose-regulated protein 78 (GRP78) and GADD153/CHOP gene mRNA and protein expression significantly (P < 0...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28054553/effect-of-dietary-astragalus-polysaccharide-supplements-on-testicular-mirna-expression-profiles-and-enzymatic-changes-of-breeder-cocks
#2
Shengru Wu, Xiaochun Ren, Yulong Li, Wei Guo, Xinyu Lei, Junhu Yao, Xiaojun Yang
Astragalus Polysaccharide (APS) is an important feed additive due to its immunomodulatory functions. Previous studies have proven that miRNAs play important roles in posttranscriptional gene regulation. Our goals were to identify differentially expressed miRNAs in testes in responses to APS dietary supplements and to find the effects of APS on breeder cock testes. We measured several enzymatic activities in testes and sperm samples and further generated miRNA expression profiles of testes from breeder cocks fed with control diets and extra APS...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28011393/astragaloside-iv-attenuates-cognitive-impairments-induced-by-transient-cerebral-ischemia-and-reperfusion-in-mice-via-anti-inflammatory-mechanisms
#3
Min Li, Hongyan Li, Fang Fang, Xueyang Deng, Shiping Ma
Astragaloside IV (AS-IV) is the main active component isolated from the traditional Chinese medicinal herb Astragalus membranaceus. Studies have demonstrated that AS-IV has neuroprotective effects in cerebral ischemic models. In this study, we aimed to investigate the effects of AS-IV on memory impairment induced by transient cerebral ischemia and reperfusion in mice, as well as the associated signaling mechanisms. Severe memory deficits were induced by bilateral common carotid artery occlusion (BCCAO) in mice as indicated in the Morris water maze test in this study...
December 21, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28002602/effect-of-astragalus-polysaccharides-on-ovariectomy-induced-osteoporosis-in-mice
#4
J Huo, X Sun
Postmenopausal osteoporosis, a common type of osteoporosis in women, has become a serious public health issue. Astragalus polysaccharides (APS), possessing various pharmacological activities, are the active ingredients of Radix Astragali. It can be advantageous in the treatment of postmenopausal osteoporosis. In the present study, we evaluated the potential therapeutic effects of APS on postmenopausal osteoporosis by using a mice model induced by ovariectomy (OVX). Forty-eight female 6-week-old outbred ICR mice were randomly divided into six groups (N = 8): Sham group, OVX group, 17 β-estradiol (E2, 0...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27960166/astragaloside-iv-enhances-cisplatin-chemosensitivity-in-non-small-cell-lung-cancer-cells-through-inhibition-of-b7-h3
#5
Cheng-Shi He, Yi-Cheng Liu, Zhi-Peng Xu, Peng-Chen Dai, Xiao-Wei Chen, De-Hai Jin
BACKGROUND: Chemoresistance is a major obstacle to successful chemotherapy for human non-small cell lung cancer (NSCLC). Astragaloside IV, the component of Astragalus membranaceus, has been reported to exhibit anti-inflammation, anti-cancer and immunoregulatory properties. In the present study, we investigated the role of astragaloside IV in the chemoresistance to cisplatin in NSCLC cells. METHODS: We established astragaloside IV-suppressed NSCLC cell lines including A549, HCC827, and NCI-H1299 and evaluated their sensitivity to cisplatin in vitro...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27939530/diverse-mesorhizobium-bacteria-nodulate-native-astragalus-and-oxytropis-in-arctic-and-subarctic-areas-in-eurasia
#6
Osei Yaw Ampomah, Seyed Abdollah Mousavi, Kristina Lindström, Kerstin Huss-Danell
Rhizobia nodulating native Astragalus and Oxytropis spp. in Northern Europe are not well-studied. In this study, we isolated bacteria from nodules of four Astragalus spp. and two Oxytropis spp. from the arctic and subarctic regions of Sweden and Russia. The phylogenetic analyses were performed by using sequences of three housekeeping genes (16S rRNA, rpoB and recA) and two accessory genes (nodC and nifH). The results of our multilocus sequence analysis (MLSA) of the three housekeeping genes tree showed that all the 13 isolates belonged to the genus Mesorhizobium and were positioned in six clades...
November 30, 2016: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/27927199/sh003-induces-apoptosis-of-du145-prostate-cancer-cells-by-inhibiting-erk-involved-pathway
#7
Yu-Jeong Choi, Youn Kyung Choi, Kang Min Lee, Sung-Gook Cho, Soo-Yeon Kang, Seong-Gyu Ko
BACKGROUND: Herbal medicines have been used in cancer treatment, with many exhibiting favorable side effect and toxicity profiles compared with conventional chemotherapeutic agents. SH003 is a novel extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes Kirilowii Maximowicz combined at a 1:1:1 ratio that impairs the growth of breast cancer cells. This study investigates anti-cancer effects of SH003 in prostate cancer cells. METHODS: SH003 extract in 30% ethanol was used to treat the prostate cancer cell lines DU145, LNCaP, and PC-3...
December 7, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27924510/global-protein-expression-analysis-of-molecular-markers-of-ds-1-47-a-component-of-implantation-promoting-traditional-chinese-medicine
#8
Yan-Ling Li, Xiao-Yan Zhang, Yu Leng, Yan-Li Wu, Jing Li, Yun-Xia Wu
This study investigated the molecular markers of DS-1-47, a component of an implantation- promoting traditional Chinese medicine consisting of Astragalus mongholicus, Atractylodes macrocephala, Scutellaria baicalensis and Dipsacales, in an attempt to clarify the molecular mechanism and action targets of DS-1-47. Controlled ovarian stimulation (COS) method was used to establish the implantation dysfunction models of mice. Animals were divided into normal pregnant group, COS model group and DS-1-47 group. Laser capture microdissection-double dimensional electrophoresis-mass spectrum (LCM-DE-MS) was used to analyze the uterine protein molecules that were possibly involved in the promotion of implantation...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27905672/oral-astragalus-huang-qi-for-preventing-frequent-episodes-of-acute-respiratory-tract-infection-in-children
#9
REVIEW
Guobin Su, Xiankun Chen, Zhuangzhu Liu, Lihong Yang, La Zhang, Cecilia Stålsby Lundborg, Zehuai Wen, Xinfeng Guo, Xindong Qin, Jueyao Liang, Xusheng Liu
BACKGROUND: Acute respiratory tract infections (ARTIs) are common in children and can involve both upper and lower airways. Many children experience frequent ARTI episodes or recurrent respiratory tract infections (RRTIs) in early life, which creates challenges for paediatricians, primary care physicians, parents and carers of children.In China, Astragalus (Huang qi), alone or in combination with other herbs, is used by Traditional Chinese Medicine (TCM) practitioners in the form of a water extract, to reduce the risk of ARTIs; it is believed to stimulate the immune system...
1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27902477/astragalus-polysaccharide-restores-autophagic-flux-and-improves-cardiomyocyte-function-in-doxorubicin-induced-cardiotoxicity
#10
Yuan Cao, Tao Shen, Xiuqing Huang, Yajun Lin, Beidong Chen, Jing Pang, Guoping Li, Que Wang, Sylvia Zohrabian, Chao Duan, Yang Ruan, Yong Man, Shu Wang, Jian Li
Doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. Unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. Previous studies demonstrated that Astragalus polysaccharide (APS), the extracts of Astragalus membranaceus, had strong anti-tumor activities and anti-inflammatory effects. However, whether APS could mitigate chemotherapy-induced cardiotoxicity is unclear thus far. We used a doxorubicin-induced neonatal rat cardiomyocyte injury model and a mouse heart failure model to explore the function of APS...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27895702/ameliorating-effect-of-erxian-decoction-combined-with-fructus-schisandrae-chinensis-wu-wei-zi-on-menopausal-sweating-and-serum-hormone-profiles-in-a-rat-model
#11
Shi Wei Wang, Fei Hua Wu, Yan Bo Zhang, Liang Zhang, Jing Su, Hei Kei Wong, Ai Hua Liu, Ho Pan Cheung, Tzi Bun Ng, Yao Tong, Stephen Cho Wing Sze
BACKGROUND: Modified Erxian decoction (MEXD), i.e., Erxian decoction (EXD) with Fructus Schisandrae chinensis (Wu Wei Zi) added, has been used to alleviate menopausal symptoms. This study aimed to investigate the effects of MEXD on menopausal sweating and serum hormone levels in a rat model of menopause after oral administration of MEXD. METHODS: Quality control of MEXD was conducted by employing a reversed-phase high performance liquid chromatography column. The three treatment groups received oral administration of MEXD in 0...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27885333/astragalus-polysaccharide-suppresses-6-hydroxydopamine-induced-neurotoxicity-in-caenorhabditis-elegans
#12
Haifeng Li, Ruona Shi, Fei Ding, Hongyu Wang, Wenjing Han, Fangli Ma, Minghua Hu, Chung Wah Ma, Zebo Huang
Astragalus membranaceus is a medicinal plant traditionally used in China for a variety of conditions, including inflammatory and neural diseases. Astragalus polysaccharides are shown to reduce the adverse effect of levodopa which is used to treat Parkinson's disease (PD). However, the neuroprotective effect of Astragalus polysaccharides per se in PD is lacking. Using Caenorhabditis elegans models, we investigated the protective effect of astragalan, an acidic polysaccharide isolated from A. membranaceus, against the neurotoxicity of 6-hydroxydopamine (6-OHDA), a neurotoxin that can induce parkinsonism...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27868250/effects-of-astragalus-membranaceus-codonopsis-pilosula-and-allicin-mixture-on-growth-performance-nutrient-digestibility-faecal-microbial-shedding-immune-response-and-meat-quality-in-finishing-pigs
#13
R X Lan, J W Park, D W Lee, I H Kim
A 12-week trial with 120 [(Landrace×Yorkshire)×Duroc] pigs (45.65 ± 1.93 kg) was conducted to evaluate the effects of Astragalus membranaceus, Codonopsis pilosula and allicin mixture (HM) supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. Pigs were allocated to one of three treatments with 0, 0.025% (HM1) and 0.05% (HM2) HM supplementation in a randomized complete block design according to sex and BW. Each treatment contained 10 replications with four pigs (two barrows and two gilts) per pen...
November 21, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27858488/cycloartane-type-triterpenoids-from-astragalus-hoantchy-french
#14
Kai Guo, Xiaofeng He, Dengxue Lu, Yanping Zhang, Xiuzhuang Li, Zhiqiang Yan, Bo Qin
A new cycloartane-type triterpenoid, 3β-acetoxy-9β,19-cyclolanost-24E-ene-1α,16β-diol-27-O-β-d-glucopyranoside (1), together with three known ones (2-4) were isolated from the aerial parts of Astragalus hoantchy. The structure of compound 1 was elucidated by detailed spectroscopic analyses including 1D and 2D NMR, HRESIMS, and IR experiments. All of the four compounds were isolated from A. hoantchy for the first time. The antifungal activities of compounds 1-4 against a phytopathogenic fungus (Alternaria solani) were evaluated with the result that compound 3 exhibited a moderate activity with an IC50 value of 284 μg/mL...
February 2017: Natural Product Research
https://www.readbyqxmd.com/read/27855303/astragaloside-iv-from-astragalus-membranaceus-ameliorates-renal-interstitial-fibrosis-by-inhibiting-inflammation-via-tlr4-nf-%C3%B0%C2%BAb-in-vivo-and-in-vitro
#15
Xiangjun Zhou, Xinbo Sun, Xiaoxin Gong, Yong Yang, Congbo Chen, Guang Shan, Qisheng Yao
Renal fibrosis is characterized by infiltration of inflammatory cells, activation and proliferation of fibroblasts, and accumulation of extracellular matrix (ECM). Astragalus membranaceus (AM) is traditional Chinese medicine and has a range of pharmacological effects. Astragaloside IV (As IV) is the main compound of AM and has anti-inflammation activities. Whether As IV ameliorates renal interstitial fibrosis by inhibiting inflammation remains unknown. Accordingly, this study investigated the ameliorating effect of As IV on renal fibrosis...
January 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27833803/germination-pretreatments-to-break-hard-seed-dormancy-in-astragalus-cicer-l-fabaceae
#16
Joseph M Statwick
Conservationists often propagate rare species to improve their long-term population viability. However, seed dormancy can make propagation efforts challenging by substantially lowering seed germination. Here I statistically compare several pretreatment options for seeds of Astragalus cicer L.: unscarified controls and scarification via physical damage, hot water, acid, and hydrogen peroxide. Although only 30% of unscarified seeds germinated, just physical scarification significantly improved germination, whereas one treatment, hot water, resulted in no germination at all...
2016: PeerJ
https://www.readbyqxmd.com/read/27814708/neuroprotective-effect-of-a-novel-chinese-herbal-decoction-on-cultured-neurons-and-cerebral-ischemic-rats
#17
Fanny Chui-Fun Ip, Yu-Ming Zhao, Kim-Wan Chan, Elaine Yee-Ling Cheng, Estella Pui-Sze Tong, Oormila Chandrashekar, Guang-Miao Fu, Zhong-Zhen Zhao, Nancy Yuk-Yu Ip
BACKGROUND: Historically, traditional Chinese medicine has been widely used to treat stroke. Based on the theory of Chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called Post-Stroke Rehabilitation (PSR), comprising seven herbs - Astragalus membranaceus (Fisch.) Bunge, Salvia miltiorrhiza Bunge, Paeonia lactiflora Pall., Cassia obtusifolia L., Ligusticum chuanxiong Hort., Angelica sinensis (Oliv.) Diels, and Glycyrrhiza uralensis Fisch...
November 4, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27794507/a-novel-survey-of-the-ethno-medicinal-knowledge-of-dental-problems-in-manoor-valley-northern-himalaya-pakistan
#18
Inayat Ur Rahman, Farhana Ijaz, Zafar Iqbal, Aftab Afzal, Niaz Ali, Muhammad Afzal, Muhammad Azhar Khan, Said Muhammad, Ghulam Qadir, Muhammad Asif
ETHNOPHARMACOLOGICAL RELEVANCE: In the study area, the traditional knowledge and cultural practices of utilizing medicinal plants in the human healthcare is primarily restricted to the old age members of the community, while younger generation is mostly unaware of the natural wealth usage. AIM OF THE STUDY: We provide the first ever ethno medicinal insights into the management of dental disorders in Pakistan. The prime objective of the study was to explore novel knowledge of these local and remote community members and share it with rest of the world in documented form...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27773802/effects-of-the-traditional-chinese-herb-astragalus-membranaceus-in-patients-with-poststroke-fatigue-a-double-blind-randomized-controlled-preliminary-study
#19
Chung-Hsiang Liu, Chang-Hai Tsai, Tsai-Chung Li, Yu-Wan Yang, Wei-Shih Huang, Ming-Kui Lu, Chun-Hung Tseng, Hui-Chun Huang, Kuan-Fei Chen, Thih-Shan Hsu, Yi-Ting Hsu, Chon-Haw Tsai, Ching-Liang Hsieh
BACKGROUND AND PURPOSE: Astragalus membranaceus (AM) is the first-choice herb for fatigue treatment in traditional Chinese medicine and the main herb used for stroke treatment in China and Taiwan. The purpose of this study was to evaluate the effect of AM on poststroke fatigue (PSF). MATERIALS AND METHODS: This study was designed as a double-blind, randomized, controlled preliminary study. Sixty-four patients with PSF were assigned to treatment group (TG; 31 patients), which received oral administration of AM (2...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27768989/effects-of-astragalus-and-codonopsis-pilosula-polysaccharides-on-alveolar-macrophage-phagocytosis-and-inflammation-in-chronic-obstructive-pulmonary-disease-mice-exposed-to-pm2-5
#20
Xu Chu, Xiao-Ju Liu, Jing-Man Qiu, Xiao-Li Zeng, Hai-Rong Bao, Juan Shu
Astragalus and Codonopsis pilosula are used for their immunomodulatory and anti-inflammatory effects. Here, we investigated the effects of Astragalus polysaccharides (APS) and Codonopsis pilosula polysaccharides (CPP) on alveolar macrophage (AM) phagocytosis and inflammation in chronic obstructive pulmonary disease (COPD) associated with exposure to particulate matter with a mean aerodynamic diameter ≤2.5μm (PM2.5). A mouse model of COPD was established by cigarette smoke exposure. PM2.5 exposure was performed by inhalation of a PM2...
December 2016: Environmental Toxicology and Pharmacology
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