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https://www.readbyqxmd.com/read/29130588/effects-of-astragalus-extract-mixture-ht042-on-height-growth-in-children-with-mild-short-stature-a-multicenter-randomized-controlled-trial
#1
Donghun Lee, Sun Haeng Lee, Jungbin Song, Hee-Jung Jee, Sung Ho Cha, Gyu Tae Chang
HT042 is a standardized functional food ingredient approved by Korean Food and Drug Administration with a claim 'HT042 can help height growth of children'. We aimed to evaluate the safety and efficacy of HT042 on height growth in children with mild short stature. A multicenter, randomized, double-blind, placebo-controlled parallel study was performed on children aged 6-8 years with height ranked below the 25th percentile. In 129 children, height gain was significantly higher in HT042 group than placebo group after 24 weeks (mean difference, 0...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29128795/chemosensitive-effects-of-astragaloside-iv-in-osteosarcoma-cells-via-induction-of-apoptosis-and-regulation-of-caspase-dependent-fas-fasl-signaling
#2
Tongzhou Hu, Zhenghua Fei, Nan Wei
BACKGROUND: The response of conventional chemotherapy for osteosarcoma treatment is usually poor, and chemotherapy-related severe side effects and drug resistance remain a problem. Abundant evidence has shown that Astragaloside IV, extracted from Astragalus membranaceus Bunge, strongly inhibits the growth of many carcinomas. We aimed to investigate the chemosensitive effects of Astragaloside IV in osteosarcoma in vitro and in vivo. METHODS: Human osteosarcoma cell lines MG-63 and 143B, and BALB/c nu/nu mice xenograft were used...
July 5, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29104457/the-extracts-of-astragalus-membranaceus-inhibit-melanogenesis-through-the-erk-signaling-pathway
#3
Yu-Tzu Tsao, Chun-Yu Kuo, Yu-Diao Kuan, Han-Chen Lin, Li-Hsien Wu, Che-Hsin Lee
Melanin is a normal production protecting skin from environment-causing damage. Plants produce some agents in response to their environment. These agents could be applied in cosmetic production. Some Chinese herbals have immunomodulatory activities and modulate the symptoms of several diseases. Melanogenesis represents a complex group of conditions that are thought to be mediated through a complex network of regulatory processes. Previously, some studies found that the extracts of Astragalus membranaceus (PG2) regulated immunity and supported hematopoiesis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29103194/astragalus-polysaccharides-increase-the-sensitivity-of-skov3-cells-to-cisplatin
#4
Caihong Li, Li Hong, Cheng Liu, Jie Min, Ming Hu, Wenjun Guo
BACKGROUND: Multidrug resistance in malignant tumours hinders the treatment of tumours. Studies showed that astragalus polysaccharides (APS), one major active ingredient of astragalus, enhanced the sensitivity of non-small cell lung cancer and liver cancer cells to chemotherapeutic drug. However, the effect of APS on ovarian cancer is still unclear. In this study, we will examine the sensitizing effect of APS on SKOV3 cells to cisplatin and explore the possible mechanism. METHODS: MTT assay was employed to examine the viability of SKOV3 after treatment with APS and cisplatin...
November 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29102246/quantification-of-isoflavonoids-and-triterpene-saponins-in-astragali-radix-the-root-of-astragalus-membranaceus-via-reverse-phase-high-performance-liquid-chromatography-coupled-with-integrated-pulsed-amperometric-detection
#5
Seung-Min Lee, Ji-Seon Jeong, Ha-Jeong Kwon, Seon-Pyo Hong
Astragali Radix, the root of Astragalus membranaceus Bunge, is one of the most frequently used crude drugs in Asian medicine. We developed a quantification method for 6 components (calycosin, formononetin, astragaloside I-IV) of Astragali Radix and Hwanggi-gyeji-omul-tang (HGOT) using reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection (RP-HPLC-IPAD). The plants were extracted in 80% ethanol for 2h. All target components were detected with good sensitivity using sodium hydroxide (as a post-column eluent)...
October 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29091441/rapid-analysis-and-guided-isolation-of-astragalus-isoflavonoids-by-uhplc-dad-msn-and-their-cellular-antioxidant-defense-on-high-glucose-induced-mesangial-cells-dysfunction
#6
Dan Tang, Ying-Bin Shen, Zhi-Hua Wang, Bao He, You-Hua Xu, Hong Nie, Quan Zhu
Isoflavonoids including isoflavones, isoflavans and pterocarpans, the principal components in Astragalus membranaceus, have a great deal of versatile health-promoting benefits. In this work, as a continuation of our searching for bioactive constituents from A. membranaceus, a fast UHPLC-DAD-MSn method was firstly used to analyze the isoflavonoids profile of A. membranaceus roots extract. Twelve diverse isoflavonoids with subclass of isoflavones, isoflavans and pterocarpans occurred in glycoside/aglycone pairs forms were tentatively characterized, of them eight major isoflavonoids were finally isolated guided and simultaneously quantified by the established fast UHPLC method...
November 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29082684/-evolution-and-characteristics-of-system-assessing-quality-by-distinguishing-features-of-traditional-chinese-medicinal-materials-of-dao-di-herbs-of-astragali-radix
#7
Hua-Sheng Peng, He-Ting Zhang, Dai-Yin Peng, Ming-En Cheng, Liang-Ping Zha, Lu-Qi Huang
"Assessing the quality by distinguishing features of traditional Chinese medicinal materials" is a characteristic quality evaluation system of traditional Chinese medicine, and it is also the basis of "Rating according to characters and setting the price by the grade" on the market. Astragali Radix was regarded as a famous traditional Chinese medicine (TCM), and this paper has carried out herbal textual research on the development and formation of the concept, "assessing the quality by distinguishing features of traditional Chinese medicinal materials", of Astragali Radix...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29070910/molecular-phylogeny-and-divergence-times-of-astragalus-section-hymenostegis-an-analysis-of-a-rapidly-diversifying-species-group-in-fabaceae
#8
Ali Bagheri, Ali Asghar Maassoumi, Mohammad Reza Rahiminejad, Jonathan Brassac, Frank R Blattner
The taxa of Astragalus section Hymenostegis are an important element of mountainous and steppe habitats in Southwest Asia. A phylogenetic hypothesis of sect. Hymenostegis has been obtained from nuclear ribosomal DNA internal transcribed spacer (ITS) and plastid ycf1 sequences of up to 303 individuals from 106 species, including all 89 taxa currently assigned to sect. Hymenostegis, 14 species of other Astragalus sections, and two species of Oxytropis and one Biserrula designated as outgroups. Bayesian phylogenetic inference and parsimony analyses reveal that three species from two other closely related sections group within sect...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051733/system-pharmacology-based-dissection-of-the-synergistic-mechanism-of-huangqi-and-huanglian-for-diabetes-mellitus
#9
Shi-Jun Yue, Juan Liu, Wu-Wen Feng, Fei-Long Zhang, Jian-Xin Chen, Lan-Ting Xin, Cheng Peng, Hua-Shi Guan, Chang-Yun Wang, Dan Yan
The rapidly increasing diabetes mellitus (DM) is becoming a major global public health issue. Traditional Chinese medicine (TCM) has a long history of the treatment of DM with good efficacy. Huangqi and Huanglian are one of the most frequently prescribed herbs for DM, and the combination of them occurs frequently in antidiabetic formulae. However, the synergistic mechanism of Huangqi (Radix Astragali) and Huanglian (Rhizoma Coptidis) has not been clearly elucidated. To address this problem, a feasible system pharmacology model based on chemical, pharmacokinetic and pharmacological data was developed via network construction approach to clarify the synergistic mechanisms of these two herbs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29047177/selected-hepatoprotective-herbal-medicines-evidence-from-ethnomedicinal-applications-animal-models-and-possible-mechanism-of-actions
#10
REVIEW
Muhammad Ali, Tariq Khan, Kaneez Fatima, Qurat Ul Ain Ali, Muhammad Ovais, Ali Talha Khalil, Ikram Ullah, Abida Raza, Zabta Khan Shinwari, Muhammad Idrees
Insight into the hepatoprotective effects of medicinally important plants is important, both for physicians and researchers. Main reasons for the use of herbal medicine include their lesser cost compared with conventional drugs, lesser undesirable drug reactions and thus high safety, and reduced side effects. The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants: Silybum marianum (L.) Gaertn., Glycyrrhiza glabra, Phyllanthus amarus Schumach...
October 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29044703/a-comparative-study-on-the-effect-of-promoting-the-osteogenic-function-of-osteoblasts-using-isoflavones-from-radix-astragalus
#11
Xianghe Kong, Fang Wang, Yinbo Niu, Xianglong Wu, Yalei Pan
Radix Astragalus has been shown to exert beneficial effects regarding the prevention postmenopausal osteoporosis. However, its mechanism of action remains to be investigated. Calycosin, formononetin, and calycosin-7-O-β-d-glucoside are the main isoflavone constituents of Astragalus. In this study, the abilities of these 3 compounds to promote osteogenic function of osteoblasts were compared, and the structure-activity relationships of these osteotrophic isoflavones were determined. Calycosin exhibited a greater effect than formononetin and calycosin-7-O-β-d-glucoside regarding improvements in osteogenic function of osteoblasts, as demonstrated by cell proliferation, alkaline phosphatase activity, collagen I and osteocalcin secretion, and the number and area of mineralized bone nodules...
October 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29039448/astragaloside-iv-attenuates-the-h2o2-induced-apoptosis-of-neuronal-cells-by-inhibiting-%C3%AE-synuclein-expression-via-the-p38-mapk-pathway
#12
Xiang Liu, Jun Zhang, Shibo Wang, Jinfu Qiu, Chao Yu
An oxidative stress insult is one of the principal causes of Parkinson's disease. Astragaloside IV (AS-IV), a constituent extracted from Astragalus membranaceus, has been demonstrated to exert antioxidant effects. However, the mechanisms responsible for the antioxidant properties and neuroprotective effects of AS-IV remain unclear. In this study, we examined the protective effects of AS-IV against the apoptosis of human neuronal cells (SH-SY5Y cells) induced by hydrogen peroxide (H2O2). The results revealed that AS-IV pre-treatment attenuated the H2O2‑induced loss of SH-SY5Y cells in a dose-dependent manner; AS-IV exerted significant protecitve effects by decreasing the apoptotic ratio and attenuating reactive oxygen species overproduction in H2O2-exposed SH-SY5Y cells...
September 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29018607/effects-of-astragalus-polysaccharide-on-the-adhesion-related-immune-response-of-endothelial-cells-stimulated-with-csfv-in-vitro
#13
Zengyu Zhuge, Yanpeng Dong, Liuan Li, Tianming Jin
BACKGROUND: Astragalus polysaccharide (APS) has immunomodulatory activities on porcine peripheral blood mononuclear cells. The immunomodulatory effects of APS on porcine endothelial cells (ECs) expose to classical swine fever virus (CSFV) remain unknown. METHODS: The virus was titrated using an indirect immune biotin enzyme standard method to confirm that porcine ECs were susceptible to CSFV infection and to determine the TCID50 of CSFV (C-strain). Porcine ECs were cultured with CSFV in the presence of APS...
2017: PeerJ
https://www.readbyqxmd.com/read/28990065/inhibition-of-cardiotrophin%C3%A2-1-overexpression-is-involved-in-the-anti%C3%A2-fibrotic-effect-of-astrogaloside%C3%A2-iv
#14
Guizhi Jia, Bin Leng, Hongxin Wang, Hongliang Dai
Astragaloside IV (AsIV), one of the major active ingredients in Astragalus membranaceus, has demonstrated remarkable antifibrotic effects via its antioxidative activity. Cardiac fibrosis is an important pathological mechanism during cardiac remodelling associated with heart failure. In the present study, the mechanism underlying the antifibrotic effect of AsIV upon isoprenaline (ISO) stimulation was investigated. AsIV significantly improved cardiac fibrosis in vivo and dose‑dependently inhibited ISO‑induced CF proliferation in vitro...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28986937/effects-of-chinese-herbal-medicine-and-cold-exposure-on-plasma-glucose-leucine-and-energy-metabolism-in-sheep
#15
X Liang, J Jin, X Bi, M Kamruzzaman, T Kudo, H Sano
An experiment was carried out to assess the feeding effect of Chinese herbal medicine on N balance, ruminal fermentation characteristics, kinetics of plasma glucose, leucine and energy metabolism in sheep kept at thermoneutral environment (23°C) or exposed to cold (2-4°C). Four sheep were subjected to either mixed hay (MH-diet) or hay supplemented with 2% of a traditional nourishing Chinese herbal medicine mixture (Astragalus root, Angelica root and Atractylodes rhizome; CHM-diet) over two 23-day periods using a crossover design...
October 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28979690/multifaceted-effects-of-astragaloside-iv-on-promotion-of-random-pattern-skin-flap-survival-in-rats
#16
Renjin Lin, Huanwen Chen, Daniel Callow, Shihen Li, Lei Wang, Shi Li, Long Chen, Jian Ding, Weiyang Gao, Huazi Xu, Jianzhong Kong, Kailiang Zhou
Random pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery, but the distal part of skin flaps often suffers necrosis due to ischemia. Astragaloside IV (AS-IV), a natural saponin purified from Astragalus membranaceus, may have beneficial functions for flap survival. In this study, rats were divided into a control group and an AS-IV treatment group, and underwent surgery using a modified "McFarlane flap" model. After intragastric administration of vehicle control or AS-IV for their respective groups, flap survival area and water content were measured 7 days after surgery...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28978164/comparative-efficacy-and-safety-of-chinese-herbal-injections-combined-with-the-folfox-regimen-for-treating-gastric-cancer-in-china-a-network-meta-analysis
#17
Dan Zhang, Jiewen Zheng, Mengwei Ni, Jiarui Wu, Kuaihuan Wang, Xiaojiao Duan, Xiaomeng Zhang, Bing Zhang
BACKGROUND: Chinese herbal injections (CHIs) have been proven beneficial to patients with gastric cancer for improving clinical efficacy and relieving adverse reactions (ADRs) of chemotherapy. A network meta-analysis (NMA) was conducted in this study to assess the comparative efficacy and safety of CHIs combined with FOLFOX regimen for treating gastric cancer. RESULTS: A total of 2316 records were searched, and 81 eligible RCTs involving 15 types of CHIs and 5978 patients were included in the NMA...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28964750/screening-for-swainsonine-among-south-american-astragalus-species
#18
Daniel Cook, Dale R Gardner, Agustin Martinez, Carlos A Robles, James A Pfister
Swainsonine is a toxic alkaloid found in several plant genera worldwide. The objective of this study was to screen several South American Astragalus species for the toxin swainsonine. Swainsonine was detected in 16 of 30 Astragalus species using liquid and gas chromatography coupled with mass spectrometry. Information in regard to the swainsonine content of these species may provide important information on the risk of grazing these toxic species.
December 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28962174/vascular-protective-effects-of-astragalus-membranaceus-and-its-main-constituents-in-rats-with-chronic-hyperhomocysteinemia
#19
Li-Hong Qiu, Bi-Qi Zhang, Miao-Jun Lian, Xian-Ji Xie, Peng Chen
Hyperhomocysteinemia (HHcy) is an important factor in cardiovascular disease. However, is currently no cure available in western medicine for HHcy-evoked cardiovascular disease. The present study explored the vascular protective effects of Astragalus membranaceus (AM), a traditional Chinese medicine. Rats with HHcy were induced by feeding high-methionine diets and treated with total extract of AM (TEA) and its constituents, including Astragalus saponins (ASP), Astragalus total flavonoids (ATF) and Astragalus polysaccharides (APS)...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28960309/pain-relieving-and-protective-effects-of-astragalus-hydroalcoholic-extract-in-rat-arthritis-models
#20
Mario Maresca, Laura Micheli, Lorenzo Cinci, Anna Rita Bilia, Carla Ghelardini, Lorenzo Di Cesare Mannelli
OBJECTIVES: The evaluation of the pharmacological profile of the dried 50% hydroalcoholic extract (50%HA) of Astragali radix in two different animal models of articular damage resembling osteoarthritis and rheumatoid arthritis. METHODS: Sodium monoiodoacetate (MIA) or complete Freund's adjuvant (CFA) was intra-articular injected (day 0) in the rat tibiotarsal joint to induce damages mimicking osteoarthritis or rheumatoid arthritis. Pain measurements (responses to non-noxious and noxious stimuli, spontaneous pain, articular pain) were assessed on days 7 and 14...
September 29, 2017: Journal of Pharmacy and Pharmacology
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