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Astragalus

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https://www.readbyqxmd.com/read/28545665/astragaloside%C3%A2-against-cardiac-fibrosis-by-inhibiting-trpm7-channel
#1
Jun Lu, Quan-Yi Wang, Yang Zhou, Xiao-Chun Lu, Yong-Hui Liu, Yan Wu, Qiao Guo, Yun-Tian Ma, Yi-Qun Tang
BACKGROUND: Astragaloside Ⅳ (ASG-Ⅳ, (Fig. 1) is the most active component of Chinese sp. Astragalus membranaceus Bunge (Fabaceae) that has showed antioxidant, antiapoptotic and antiviral activities among others. It is reported to play an important role in cardiac fibrosis (CF), but the mechanism remains unclear. PURPOSE: To investigate the mechanism of ASG-Ⅳ on inhibiting myocardial fibrosis induced by hypoxia. STUDY DESIGN: We studied the relationship between anti-fibrotic effect of ASG-Ⅳ and transient receptor potential cation channel, subfamily M, member 7 (TRPM7) by in vivo and in vitro experiments...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28536021/effect-of-dietary-astragalus-polysaccharide-supplements-on-testicular-pirna-expression-profiles-of-breeding-cocks
#2
Shengru Wu, Yulong Li, Si Chen, Saisai Liang, Xiaochun Ren, Wei Guo, Qingzhu Sun, Xiaojun Yang
Astragalus polysaccharide (APS), as the main active ingredient of Astragalus membranaceus, has extensive biological activities related to immune, metabolic, and anti-oxidative regulatory processes. Previous studies have proven that piRNAs could play important roles in genital gland. This study aimed to identify the differentially expressed piRNAs in chicken testes in response to dietary APS supplements and further evaluate the roles of these piRNAs related to the effect of dietary APS supplements on testicular changes...
May 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28533813/rapid-identification-of-growth-years-and-profiling-of-bioactive-ingredients-in-astragalus-membranaceus-var-mongholicus-huangqi-roots-from-hunyuan-shanxi
#3
Hua-Sheng Peng, Jun Wang, He-Ting Zhang, Hai-Yan Duan, Xiao-Mei Xie, Ling Zhang, Ming-En Cheng, Dai-Yin Peng
BACKGROUND: The content of medicinal bioactive constituents in huangqi is affected by plant age. In this study, we devised a quick and convenient method for determining the age of huangqi, which was cultivated in Hunyuan County (Shanxi Province). METHODS: 1, 2, 3, 4, 5, 8, 10 growth years huangqi had 38 samples, all samples were collected separately. The growth rings in these samples were observed after making paraffin section and freehand-section. The relationship between growth rings and its growth years was analyzed by SPSS 19...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28529539/jiangtang-decoction-ameliorate-diabetic-nephropathy-through-the-regulation-of-pi3k-akt-mediated-nf-%C3%AE%C2%BAb-pathways-in-kk-ay-mice
#4
Jin-Ni Hong, Wei-Wei Li, Lin-Lin Wang, Hao Guo, Yong Jiang, Yun-Jia Gao, Peng-Fei Tu, Xue-Mei Wang
BACKGROUND: Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28528516/combined-effects-of-chinese-medicine-feed-and-ginger-extract-bath-on-co-infection-of-ichthyophthirius-multifiliis-and-dactylogyrus-ctenopharyngodonid-in-grass-carp
#5
Yao-Wu Fu, Bin Wang, Qi-Zhong Zhang, De-Hai Xu, De-Jie Lin, Xing-Ya Yang, Shu-Qun Zhu, Jing-Yang Pan, Qian Deng, Yan-Meng Liu, Sheng-Yu Zhou
Dactylogyrus ctenopharyngodonid and Ichthyophthirius multifiliis are two important ectoparasites of freshwater fish. Co-infection by the two parasites leads to high fish mortality and results in heavy economic losses. This study aimed to evaluate the efficacy of medicated feed and a ginger extract bath against D. ctenopharyngodonid and I. multifiliis on grass carp and investigate the hematological response of grass carp co-infected by the two parasites. These results demonstrated that red blood cell (RBC) and thrombocyte percentage among leucocytes significantly decreased after grass carp were co-infected by D...
May 20, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28521513/astragalus-polysaccharides-attenuate-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats
#6
Lin-Bo Yuan, Chun-Yan Hua, Sheng Gao, Ya-Ling Yin, Mao Dai, Han-Yan Meng, Piao-Piao Li, Zhong-Xin Yang, Qing-Hua Hu
Astragalus polysaccharides (APS) have been shown to possess a variety of biological activities including anti-oxidant and anti-inflammation functions in a number of diseases. However, their function in pulmonary arterial hypertension (PAH) is still unknown. Rats received APS (200[Formula: see text]mg/kg once two days) for 2 weeks after being injected with monocrotaline (MCT; 60[Formula: see text]mg/kg). The pulmonary hemodynamic index, right ventricular hypertrophy, and lung morphological features of the rat models were examined, as well as the NO/eNOS ratio of wet lung and dry lung weight and MPO...
May 18, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28490383/erratum-to-chtlr4-pathway-activation-by-astragalus-polysaccharide-in-bursa-of-fabricius
#7
Ruili Zhang, Qun Yu, Guangliang Shi, Rui Liu, Weiqian Zhang, Xia Zhao, Guangxing Li, Ming Ge
No abstract text is available yet for this article.
May 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28487940/astragalus-polysaccharide-ameliorates-h2o2-induced-human-umbilical-vein-endothelial-cell-injury
#8
Ronghui Han, Futian Tang, Meili Lu, Chonghua Xu, Jin Hu, Meng Mei, Hongxin Wang
Endothelial dysfunction caused by reactive oxygen species (ROS) has been implicated in numerous cardiovascular diseases. Astragalus polysaccharide (APS), an important bioactive component extracted from the Chinese herb Astragalus membranaceus, has been widely used for the treatment of cardiovascular disease. The present study aimed to investigate the effects of APS on hydrogen peroxide (H2O2)‑induced human umbilical vein endothelial cell (HUVEC) injury. Following treatment with 400 µM H2O2 for 24 h, cell viability was decreased and apoptosis was increased...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28482267/amelioration-of-ccl4-induced-liver-injury-in-rats-by-selenizing-astragalus-polysaccharides-role-of-proinflammatory-cytokines-oxidative-stress-and-hepatic-stellate-cells
#9
Mohammed Hamid, Dandan Liu, Yassin Abdulrahim, Yunhuan Liu, Gang Qian, Alamzeb Khan, Fang Gan, Kehe Huang
Selenizing Astragalus polysaccharides (sAPS) were prepared by nitric acid-sodium selenite method. Effect of sAPS on carbon tetrachloride (CCl4)-induced liver injury and the underlying mechanisms were investigated in the rat. Forty male Wistar rats were divided into five equal groups as follows: control group; CCl4 group; CCl4+Astragalus polysaccharides group; CCl4+sodium selenite group and CCl4+selenizing Astragalus polysaccharides group. The results showed that sAPS significantly decreased the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase in the serum, malondialdehyde and hydroxyproline content in liver (P<0...
May 2, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28480132/osteology-of-galeamopus-pabsti-sp-nov-sauropoda-diplodocidae-with-implications-for-neurocentral-closure-timing-and-the-cervico-dorsal-transition-in-diplodocids
#10
Emanuel Tschopp, Octávio Mateus
Diplodocids are among the best known sauropod dinosaurs. Numerous specimens of currently 15 accepted species belonging to ten genera have been reported from the Late Jurassic to Early Cretaceous of North and South America, Europe, and Africa. The highest diversity is known from the Upper Jurassic Morrison Formation of the western United States: a recent review recognized 12 valid, named species, and possibly three additional, yet unnamed ones. One of these is herein described in detail and referred to the genus Galeamopus...
2017: PeerJ
https://www.readbyqxmd.com/read/28469657/fermented-chinese-formula-shuan-tong-ling-attenuates-ischemic-stroke-by-inhibiting-inflammation-and-apoptosis
#11
Zhi-Gang Mei, Ling-Jing Tan, Jin-Feng Wang, Xiao-Li Li, Wei-Feng Huang, Hua-Jun Zhou
The fermented Chinese formula Shuan-Tong-Ling is composed of radix puerariae (Gegen), salvia miltiorrhiza (Danshen), radix curcuma (Jianghuang), hawthorn (Shanzha), salvia chinensis (Shijianchuan), sinapis alba (Baijiezi), astragalus (Huangqi), panax japonicas (Zhujieshen), atractylodes macrocephala koidz (Baizhu), radix paeoniae alba (Baishao), bupleurum (Chaihu), chrysanthemum (Juhua), rhizoma cyperi (Xiangfu) and gastrodin (Tianma), whose aqueous extract was fermented with lactobacillus, bacillus aceticus and saccharomycetes...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28464901/chtlr4-pathway-activation-by-astragalus-polysaccharide-in-bursa-of-fabricius
#12
Ruili Zhang, Qun Yu, Guangliang Shi, Rui Liu, Weiqian Zhang, Xia Zhao, Guangxing Li, Ming Ge
BACKGROUND: The Toll-like receptor 4 (TLR4) pathway involves in the pathogen recognition and defense against infection in mammals. Considering that avian and mammalian TLR are differentially mediated, the action of a natural product on avian TLR4 pathway was unclear. High, medium and low doses of Astragalus polysaccharide (APS), were treated the chicken at 7-days-old age by gavage. The sIgA level in the intestinal fluid, the expression of chTLR4 mRNA/protein in bursa of Fabricius as well as the expression of downstream molecules of chTLR4 (chMyD88, chTRIF, chNF-κB, chIRF3, chIFN-β and chTNF-α) were measured on alternate days...
May 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28460429/cardioprotective-mechanisms-of-phytochemicals-against-doxorubicin-induced-cardiotoxicity
#13
REVIEW
Abdelrahman Ibrahim Abushouk, Ammar Ismail, Amr Muhammad Abdo Salem, Ahmed M Afifi, Mohamed M Abdel-Daim
Doxorubicin (DOX) is an anthracycline antibiotic, which is effectively used in the treatment of different malignancies, such as leukemias and lymphomas. Its most serious side effect is dose-dependent cardiotoxicity, which occurs through inducing oxidative stress apoptosis. Due to the myelosuppressive effect of dexrazoxane, a commonly-used drug to alleviate DOX-induced cardiotoxicity, researchers investigated the potential of phytochemicals for prophylaxis and treatment of this condition. Phytochemicals are plant chemicals that have protective or disease preventive properties...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28458344/effects-of-astragalus-combined-with-angelica-on-bone-marrow-hematopoiesis-suppression-induced-by-cyclophosphamide-in-mice
#14
Fei Li, Rong Tang, Ling-Bo Chen, Ke-Sheng Zhang, Xiao-Ping Huang, Chang-Qing Deng
Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28454485/cheminformatics-based-anticoagulant-study-of-traditionally-used-medicinal-plants
#15
Mahdi Alikhani Pour, Soroush Sardari, Ali Eslamifar, Abid Azhar, Mohammad Rezvani, Milad Nazari
Backgroung: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. Methods: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists...
April 29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28443459/astragaloside-iv-sensitizes-non-small-cell-lung-cancer-cells-to-gefitinib-potentially-via-regulation-of-sirt6
#16
Peng-Chen Dai, De-Ling Liu, Lei Zhang, Jia Ye, Qing Wang, Hong-Wen Zhang, Xiu-Hua Lin, Guo-Xiang Lai
Astragaloside IV, the active component of Astragalus membranaceus, exhibits diverse biological roles including the anti-tumor activity. In this study, we evaluated the chemosensitive role of astragaloside IV in non-small cell lung cancer cells. Cell Counting Kit-8 analysis was performed to determine cell viability. Real-time polymerase chain reaction and western blot were used to measure the messenger RNA and protein expression. Results showed that astragaloside IV treatment could suppress the proliferation of non-small cell lung cancer cells...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28440420/wound-healing-effect-of-an-astragalus%C3%A2-membranaceus-polysaccharide-and-its-mechanism
#17
Bingjiang Zhao, Xuanfen Zhang, Wei Han, Ju Cheng, Yonghong Qin
In the present study, a novel polysaccharide, APS2-1, was isolated and purified from Astragalus membranaceus using DEAE-cellulose and Sephadex G-100 chromatography. The effect of APS2‑1 on the promotion of wound healing was evaluated and its preliminary mechanism was investigated. In vitro experiments showed that APS2‑1 was able to promote human skin fibroblast (HSF) propagation and accelerate cell cycle progression. For further examination, a scalded mice model was used to verify the effect of APS2‑1 and investigate its mechanism of action...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28417089/demographic-and-medication-characteristics-of-traditional-chinese-medicine-users-among-colorectal-cancer-survivors-a-nationwide-database-study-in-taiwan
#18
Chien-Tung Wu, Yueh-Ting Tsai, Jung-Nien Lai
Chinese herbal product (CHP) is the major type of traditional Chinese medicine (TCM) and widely used to relief the symptom of colorectal cancer. The aim of the study was to analyze the utilization of CHP for treating patients with colorectal cancer in Taiwan. The usage of CHP, frequency of services, and prescription pattern for colorectal cancer were analyzed from a randomly sampled cohort of 1 million beneficiaries from the National Health Insurance Research Database. The odds ratios for utilization of CHP were estimated with logistic regression model...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28412682/application-frequency-and-therapeutic-effect-of-astragalus-in-treating-ischemic-cerebrovascular-disease
#19
Yajie Dong, Kaifeng Lu, Weijuan Gao
In recent years, Traditional Chinese Medicine (TCM) therapy has achieved substantial progress and development, playing an important role in clinical practice. In this paper, to explore the therapeutic effect of Astragalus in treating ischemic cerebrovascular disease, 2687 patients with ischemic cerebrovascular disease who had been treated with Astragalus therapy from Jan 2014-Oct 2015 were selected as the research objects. Through retrospective analysis of their medical records, we analyzed the application frequency of Astragalus using quantitative method of information, and conducted specific analysis on the therapeutic effect of Astragalus after fully surveyed patients' physical conditions after treatment...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28395722/-inhibitory-effect-and-the-mechanism-of-astragalus-polysaccharide-combined-with-cisplatin-on-growth-of-inplanted-lewis-lung-carcinoma-in-mice
#20
Mengjie Zhuang, Dan Liu, Yanwen Chen, Haixia Ming, Yang Li
Objective To observe the effect of Astragalus polysaccharides (APS) combined with cisplatin (DDP) on the expressions of cytochrome C (CytC) and high temperature required serine protease A2 (Omi/HtrA2) in the mice with Lewis lung carcinoma (LLC) transplantated tumors. Methods Ninty C57BL/6J mice were randomly divided into normal control group, model group, and (50, 100, 200) μg/mL APS groups, 6 mg/kg DDP group, 3 mg/kg DDP combined with (50, 100, 200) μg/mL APS groups. Each group included 10 mice. Except the mice in the normal group, the rest mice were inoculated subcutaneously with LLC cells (1×10(7) mL) at the right fore axillary fossa to establish tumor-bearing mouse models...
April 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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