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https://www.readbyqxmd.com/read/28339712/effect-of-chinese-herbal-medicine-treatment-on-plasma-lipid-profile-and-hepatic-lipid-metabolism-in-hetian-broiler
#1
Z Xie, J Zhang, S Ma, X Huang, Y Huang
The purpose of this study was to investigate whether adding a Chinese herbal hedicine (CHM, including astragalus membranaceus, codonopsis pilosula, poria cocos, bighead atractylodes rhizome, fructus crataegi, folium epimedii, radix saposhnikoviae, and pericarpium citri reticulatae) diet has effects on lipid metabolism in the liver of the broiler. Six-hundred-thirty Hetian broilers were divided into 3 groups including base diet (control), 0.3%, or 1% CHM diets, for 130 days. The results showed that CHM treatment significantly increased the slaughter performance...
February 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28303957/astragalus-polysaccharides-exerts-immunomodulatory-effects-via-tlr4-mediated-myd88-dependent-signaling-pathway-in-vitro-and-in-vivo
#2
Lijing Zhou, Zijing Liu, Zhixue Wang, Shuang Yu, Tingting Long, Xing Zhou, Yixi Bao
Astragalus polysaccharides (APS), which is widely used as a remedy to promote immunity of breast cancer patients, can enhance immune responses and exert anti-tumor effects. In this study, we investigated the effects and mechanisms of APS on macrophage RAW 264.7 and EAC tumor-bearing mice. Griess reaction and ELISA assays revealed that the concentrations of nitric oxide, TNF-α, IL-1β and IL-6 were increased by APS. However, this effect was diminished in the presence of TAK-242 (TLR4 inhibitor) or ST-2825(MyD88 inhibitor)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290732/cycloastragenol-mediates-activation-and-proliferation-suppression-in-concanavalin-a-induced-mouse-lymphocyte-pan-activation-model
#3
Chenghong Sun, Mingmin Jiang, Li Zhang, Jian Yang, Guimin Zhang, Bingyuan Du, Yushan Ren, Xin Li, Jingchun Yao
CONTEXT: Cycloastragenol (CAG) is a molecule isolated from various species in the genus Astragalus. Although the regulatory activity of Astragalus on immune system has been investigated, the effect of CAG on activated lymphocytes is poorly understood. OBJECTIVE: We aimed to biologically address the possible anti-inflammation potential of CAG on concanavalin A (Con A)-mediated mouse lymphocyte pan-activation model. MATERIALS AND METHODS: Mouse lymphocytes were obtained from spleens and subjected to Con A for 24 h...
March 14, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28262116/its2-barcoding-dna-region-combined-with-high-resolution-melting-hrm-analysis-of-hyoscyami-semen-the-mature-seed-of-hyoscyamus-niger
#4
Chao Xiong, Zhi-Gang Hu, Yuan Tu, He-Gang Liu, Ping Wang, Ming-Ming Zhao, Yu-Hua SHIi, Lan Wu, Wei Sun, Shi-Lin Chen
Hyoscyami Semen, the mature dried seed of Hyoscyamus niger L., has long been used as a traditional Chinese medicine to treat human diseases. Hyoscyami Semen is found in local markets in China. In markets, sellers and buyers commonly inadvertently mix the seeds of H. niger with the seeds of related species such as Hygrophila salicifolia (Vahl) Nees, Astragalus complanatus R. Br., Cuscuta australis R. Br., Cuscuta chinensis Lam., and Impatiens balsamina L. because of their similar morphologies or similar names...
December 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28260010/astragaloside-iv-inhibits-isoprenaline%C3%A2-induced-cardiac-fibrosis-by-targeting-the-reactive-oxygen-species-mitogen%C3%A2-activated-protein-kinase-signaling-axis
#5
Hongliang Dai, Guizhi Jia, Meili Lu, Chunguang Liang, Yue Wang, Hongxin Wang
Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. Astragaloside IV (AsIV) is a major active ingredient in Astragalus membranaceus. In a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotective effects via preventing cardiomyocyte hypertrophy and apoptosis. The present study aimed to investigate the effects of AsIV on β‑adrenergic receptor (β‑AR)‑mediated cardiac fibrosis, and the associated mechanism...
February 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28243851/inactivation-of-kupffer-cells-by-selenizing-astragalus-polysaccharides-prevents-ccl4-induced-hepatocellular-necrosis-in-the-male-wistar-rat
#6
Mohammed Hamid, Dandan Liu, Yassin Abdulrahim, Alamzeb Khan, Gang Qian, Kehe Huang
Selenizing astragalus polysaccharides-3 (sAPS3) was prepared by nitric acid-sodium selenite method. The effects of sAPS3 on carbon tetrachloride (CCl4) induced hepatocellular necrosis, and its underlying mechanisms were studied in male Wistar rats. Hepatic damage was induced by intraperitoneal injection of CCl4 twice a week, for 3 weeks. Meanwhile, the rats in addition to CCl4 were also exposed to sodium selenite (SS), astragalus polysaccharides (APS), SS + APS or sAPS3, in parallel by oral gavage once a day for 3 weeks...
February 27, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28242544/antibacterial-evaluation-of-sliver-nanoparticles-synthesized-by-polysaccharides-from-astragalus-membranaceus-roots
#7
Yihua Ma, Congyan Liu, Ding Qu, Yan Chen, Mengmeng Huang, Yuping Liu
This work introduced an eco-friendly approach for the synthesis of sliver nanoparticles (AgNPs) with a water-soluble fraction of polysaccharides extracted from the roots of Astragalus membranaceus (AMWP). AMWP mediated AgNPs (AMWP-AgNPs) were successfully synthesized using 1.0mM AgNO3 and 1.25mg/mL AMWP, reacting in aqueous environment at 25°C for 6h. The synthesized AMWP-AgNPs exhibited a broad surface plasmon resonance peak (SPR) at 445nm in Ultraviolet-visible (UV-vis) spectrum, which was characteristic of a poly-dispersed AMWP-AgNPs...
February 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28210201/therapeutic-effect-of-astragalus-polysaccharides-on-hepatocellular-carcinoma-h22-bearing-mice
#8
Xiaoyu Lai, Weibiao Xia, Jing Wei, Xinghong Ding
The purpose of this study was to investigate the effect of astragalus polysaccharides (APSs), active constituents of astragalus, in the treatment of hepatocellular carcinoma (HCC) and their potential as a promising candidate for future anticancer drug development. Astragalus polysaccharide was administered at different doses to HCC H22-bearing mice to investigate their antitumor effects. Results revealed that APS inhibited the growth of H22 cells with a tumor inhibition rate in the APS 400 mg·kg(-1) group of 59...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28209394/ensifer-shofinae-sp-nov-a-novel-rhizobial-species-isolated-from-root-nodules-of-soybean-glycine-max
#9
Wen Hao Chen, Sheng Hui Yang, Zhao Hu Li, Xiao Xia Zhang, Xin Hua Sui, En Tao Wang, Wen Xin Chen, Wen Feng Chen
Two bacterial strains isolated from root nodules of soybean were characterized phylogenetically as members of a distinct group in the genus Ensifer based on 16S rRNA gene comparisons. They were also verified as a separated group by the concatenated sequence analyses of recA, atpD and glnII (with similarities ≤93.9% to the type strains for defined species), and by the average nucleotide identities (ANI) between the whole genome sequence of the representative strain CCBAU 251167(T) and those of the closely related strains in Ensifer glycinis and Ensifer fredii (90...
February 2, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/28188801/astragalus-polysaccharides-protect-against-dextran-sulfate-sodium-induced-colitis-by-inhibiting-nf-%C3%AE%C2%BA%C3%B0-activation
#10
Jun Lv, Yahong Zhang, Zhiqiang Tian, Fang Liu, Ying Shi, Yao Liu, Peiyuan Xia
Astragalus polysaccharide (APS) is a bioactive extract of Astragalus membranaceus (AM), which possess a wide range of medicinal benefits, including anti-inflammatory, anti-oxidative, anti-tumor and anti-diabetic effects. The present work evaluated the therapeutic effect of APS and its potential mechanisms in a mouse model of dextran sulfate sodium (DSS)-induced colitis. The APS treatment led to significant improvements in colitis disease activity index (DAI) and histological scores, as well as significantly increased weight and colon length in mice as compared to the control group...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28164139/dietary-supplementation-of-astragalus-polysaccharides-enhanced-immune-components-and-growth-factors-egf-and-igf-1-in-sow-colostrum
#11
Lunbo Tan, Ting Wei, Anwen Yuan, Jun He, Jinhui Liu, Daojun Xu, Qing Yang
Colostrum is the main external resource providing piglets with nutrients and maternal immune molecules. Astragalus polysaccharides (APS) have been used as immunopotentiators in vitro and several animal models. This study aimed to determine the effects of APS on immune factors in sow colostrum and milk. The sow diet was supplemented with APS one week before the expected delivery date. Colostrum and milk were collected and designated as 0 h- (onset of parturition), 12 h-, and 24 h-colostrum and 36 h-milk postpartum...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28163960/screening-for-antibacterial-and-antibiofilm-activities-in-astragalus-angulosus
#12
Hussein Kanaan, Majid El-Mestrah, Alaa Sweidan, Falah As-Sadi, Ali Al Bazzal, Ali Chokr
AIM: In a search for finding novel therapeutic agents, extracts from an endemic Lebanese plant, Astragalus angulosus, were evaluated for their potential in-vitro antibacterial and antibiofilm activities against three Gram-positive bacterial strains; Staphylococcus epidermidis (CIP444), Staphylococcus aureus (ATCC25923), and Enterococcus faecalis (ATCC29212); in addition to two Gram-negative strains, Escherichia coli (ATCC35218) and Pseudomonas aeruginosa (ATCC27853). MATERIALS AND METHODS: The plant was collected in April of 2013 and divided into several different portions, then its extracts were obtained by maceration using two different solvents...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28155255/a-screen-for-swainsonine-in-select-north-american-astragalus-species
#13
Daniel Cook, Dale R Gardner, James A Pfister, Stephen T Lee, Kevin D Welch, Stanley L Welsh
Swainsonine is found in several plant species worldwide, and causes severe toxicosis in livestock grazing these plants, leading to a chronic condition characterized by weight loss, altered behavior, depression, decreased libido, infertility, and death. Swainsonine has been detected in 13 North American Astragalus species of which eight belong to taxa in four taxonomic sections, the Densifolii, Diphysi, Inflati, and Trichopodi. These sections belong to two larger groups representing several morphologically related species, the Pacific Piptolobi and the small-flowered Piptolobi...
February 2, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28150820/astragaloside-iv-ameliorates-2-4-6-trinitrobenzene-sulfonic-acid-tnbs-induced-colitis-implicating-regulation-of-energy-metabolism
#14
Xu-Guang Jiang, Kai Sun, Yu-Ying Liu, Li Yan, Ming-Xia Wang, Jing-Yu Fan, Hong-Na Mu, Chong Li, Yuan-Yuan Chen, Chuan-She Wang, Jing-Yan Han
Dysfunction of energy metabolism is involved in inflammatory bowel disease (IBD). This study was designed to investigate the potential of astragaloside IV (ASIV), an active ingredient of Radix Astragalus, to ameliorate colonic mucosal injury, with focusing on the implication of energy restoration in the underlying mechanism. Experimental colitis model was established in rats by injecting 2,4,6-trinitrobenzene sulfonic acid (TNBS) through anus. After 24 hours, ASIV was administrated once daily by gavage for 6 days...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28139929/chlorinated-dehydrocurvularins-and-alterperylenepoxide-a-from-alternaria-sp-ast0039-a-fungal-endophyte-of-astragalus-lentiginosus
#15
Bharat P Bashyal, E M Kithsiri Wijeratne, Joseph Tillotson, A Elizabeth Arnold, Eli Chapman, A A Leslie Gunatilaka
Investigation of Alternaria sp. AST0039, an endophytic fungus obtained from the leaf tissue of Astragalus lentiginosus, led to the isolation of (-)-(10E,15S)-4,6-dichloro-10(11)-dehydrocurvularin (1), (-)-(10E,15S)-6-chloro-10(11)-dehydrocurvularin (2), (-)-(10E,15S)-10(11)-dehydrocurvularin (3), and alterperylenepoxide A (4) together with scytalone and α-acetylorcinol. Structures of 1 and 4 were established from their spectroscopic data, and the relative configuration of 4 was determined with the help of nuclear Overhauser effect difference data...
February 24, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28139790/formononetin-inhibits-human-bladder-cancer-cell-proliferation-and-invasiveness-via-regulation-of-mir-21-and-pten
#16
Yiying Wu, Xing Zhang, Zhengzhao Li, Haibiao Yan, Jian Qin, Tianyu Li
The isoflavone formononetin is the main active component of Astragalus membranaceus and possesses anti-tumorigenic properties. However, the role of formononetin in human bladder cancer (BCa) has not been fully elucidated. The aim of the present study was to investigate the anti-tumor effects of formononetin on BCa cells and its potential molecular mechanism. T24 cells were treated with different concentrations of formononetin, and then the cell proliferation was assessed by MTT assay, cell apoptosis by Hoechst 33258 stain assay, cell invasiveness by transwell invasion assay, microRNA-21 (miR-21) expression by real-time PCR and the protein level of phosphatase and tensin homolog (PTEN) and phosphorylated homolog of Akt (p-Akt) by western blotting...
January 31, 2017: Food & Function
https://www.readbyqxmd.com/read/28126039/rhizobium-arenae-sp-nov-isolated-from-the-sand-of-desert-mu-us-china
#17
Shengnan Zhang, Shanshan Yang, Wei Chen, Yong Chen, Mingjuan Zhang, Xinai Zhou, Guohua Fan, Fu Ying Feng
A Gram-strain-negative, rod-shaped, motile bacterium, designated MIM27T, was isolated from the sand of Desert Mu Us, China. The strain could grow at 4-45 °C (optimum, 37 °C), at pH 6.5-9.0 (optimum, 8.0) and in the presence of 0-3 % (w/v) NaCl (optimum, 0 %). Phylogenetic analysis on 16S rRNA gene sequence demonstrated that the strain was belonged to the genus Rhizobium, with the highest similarity (96.5 %) to Rhizobium pakistanensis BN-19T. Analysis of nitrogen fixation gene nifH and three housekeeping gene sequences of recA, atpD and glnII were also showed that strain MIM27T was mostly related to the recognized species of the genus Rhizobium but the similarities were low ( 90...
January 23, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28124680/chemosensitizing-effect-of-astragalus-polysaccharides-on-nasopharyngeal-carcinoma-cells-by-inducing-apoptosis-and-modulating-expression-of-bax-bcl-2-ratio-and-caspases
#18
Zhen Zhou, Minhua Meng, Haifeng Ni
BACKGROUND Platinum-based chemotherapy is the most effective regimen for nasopharyngeal carcinoma, which presents highly invasive and metastatic activity. However, the dose-related toxicity of chemotherapy agents limits the dose administration. Astragalus polysaccharide (APS) is the major active ingredient extracted from Chinese herb Radix Astragali and is proven to be active against carcinomas. We aimed to assess the chemosensitizing effects of Astragalus polysaccharides on nasopharyngeal carcinoma in vitro and in vivo and to explore the underlying mechanism...
January 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28122556/therapeutic-effects-of-qian-yu-decoction-and-its-three-extracts-on-carrageenan-induced-chronic-prostatitis-chronic-pelvic-pain-syndrome-in-rats
#19
Keda Zhang, Xiaobin Zeng, Yonggang Chen, Rong Zhao, Hui Wang, Jinhu Wu
BACKGROUND: Qian-Yu decoction (QYD) is a traditional Chinese medicinal recipe composed of Radix astragali (Astragalus membranaceus (Fisch.) Bunge var. mongholicus (Bunge) P.K. Hsiao, Fabaceae ), Herba epimedii (Epimedium brevicornum Maxim., Berberidaceae), Herba leonuri (Leonurus japonicus Houtt., Lamiaceae), Cortex phellodendri (Phellodendron chinense Schneid., Rutaceae) and Radix achyranthis bidentatae (Achyranthes bidentata Bl., Amaranthaceae). This study aimed to evaluate the therapeutic activity of QYD against carrageenan-induced chronic prostatic/chronic pelvic pain syndrome (CP/CPPS) in rats and further elucidate its effective components...
January 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28115285/luhong-formula-inhibits-myocardial-fibrosis-in-a-paracrine-manner-by-activating-the-gp130-jak2-stat3-pathway-in-cardiomyocytes
#20
Huiyan Qu, Yong Wang, Yingjie Wang, Tao Yang, Zhou Feng, Yang Qu, Hua Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Luhong formula (LHF)-a traditional Chinese medicine containing Cervus nippon Temminck,Carthamus tinctorius L., Cinnamomum cassia Presl,Codonopisis pilosula( Franch.) Nannf., Astragalus membranaceus ( Fisch.) Bge. var. mongholicus ( Bge.) Hsiao, Lepidium apetalum Willd-is used in the treatment of heart failure. AIM OF THE STUDY: To investigate the antifibrotic efficacy of LHF in a myocardial infarction-induced rat model of heart failure and to determine its mechanism of action...
January 20, 2017: Journal of Ethnopharmacology
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