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https://www.readbyqxmd.com/read/29775897/the-gastric-mucosal-protective-effects-of-astragaloside-iv-in-mnng-induced-gpl-rats
#1
Tiantian Cai, Chengzhe Zhang, Ziming Zhao, Siyi Li, Haobin Cai, Xiaodong Chen, Dake Cai, Wei Liu, Yan Yan, Kaifeng Xie, Huafeng Pan, Xiaohui Zeng
Gastric Cancer is one of the most common types of cancer. And the occurrence of gastric carcinoma is an evolutionary histopathological stage. As a result, further research of GPL, which is a borderline of gastric cancer, is indispensable for preventing the formation and development of gastric carcinoma. Several studies have demonstrated a correlation between the expression of autophagy, apoptosis and Gastric cancer (GC). However, the effects of autophagy and apoptosis on human gastric cancer progression, particularly on gastric precancerous lesions (GPL), have not totally been investigated...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29738446/quantitative-and-discriminative-evaluation-of-contents-of-phenolic-and-flavonoid-and-antioxidant-competence-for-chinese-honeys-from-different-botanical-origins
#2
Shi Shen, Jingbo Wang, Qin Zhuo, Xi Chen, Tingting Liu, Shuang-Qing Zhang
Phenolics and flavonoids in honey are considered as the main phytonutrients which not only act as natural antioxidants, but can also be used as floral markers for honey identification. In this study, the chemical profiles of phenolics and flavonoids, antioxidant competences including total phenolic content, DPPH and ABTS assays and discrimination using chemometric analysis of various Chinese monofloral honeys from six botanical origins (acacia, Vitex , linden, rapeseed, Astragalus and Codonopsis ) were examined...
May 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29729707/swainsonine-induces-apoptosis-of-rat-cardiomyocytes-via-mitochondria%C3%A2-mediated-pathway
#3
Xiang Zheng, Shushu Wang, Dakai Chen, Xiaoming Yang
Swainsonine is an Astragalus membranaceus extract. It is indole, alkaloid, and soluble in water. Its effect on rat cardiomyocytes apoptosis, and the mechanisms underlying that effect, were investigated by inducing apoptosis in H9c2 cells. This was detected by MTT assay, Annexin V-FITC/propidium iodide double staining and western blotting. Flow cytometry and fluorescence microscopy were used to confirm swainsonine's effect on mitochondrial membrane potential and levels of reactive oxygen species, while an ATP-dependent bioluminescence assay kit served to find the ATP contents...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29729701/molecular-cloning-and-biotic-elicitation-response-of-phenylalanine-ammonia-lyase-gene-of-astragalus-chrysochlorus
#4
Neslihan Turgut Kara, Özgür Çakır, Burcu Arıkan, Şule Arı
Phenylalanine ammonia lyase (PAL) is the first enzyme of the phenylpropanoid pathway, and it is necessary to upregulate flavonoid biosynthesis in most of the plant species. In this study, we have cloned PAL gene from endemic Astragalus chrysochlorus which is a producer of phenolic nicotiflorin (kaempferol-3-O-rutinoside). The cDNA encoding PAL was cloned from A. chrysochlorus using RT-PCR (reverse transcription-polymerase chain reaction) with conserved primer pairs. Amino acid sequence alignments showed that AcPAL (2160 bp, Accession number: KM189182) has more than 95% amino acid identity with their homologues in other Astragalus species...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29722328/compound-of-icariin-astragalus-and-puerarin-mitigates-iron-overload-in-the-cerebral-cortex-of-alzheimer-s-disease-mice
#5
Yu Zhang, Wei-Na Kong, Xi-Qing Chai
Increasing evidence indicates that disruption of normal iron homeostasis may contribute to pathological development of Alzheimer's disease. Icariin, astragalus, and puerarin have been shown to suppress iron overload in the cerebral cortex and improve spatial learning and memory disorders in Alzheimer's disease mice, although the underlying mechanism remains unclear. In the present study, APPswe/PS1ΔE9 transgenic mice were administered icariin, astragalus, and puerarin (120, 80, and 80 mg/kg, respectively, once a day, for 3 months)...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29719380/astragalus-polysaccharides-protect-cardiac-stem-and-progenitor-cells-by-the-inhibition-of-oxidative-stress-mediated-apoptosis-in-diabetic-hearts
#6
Wei Chen, Jing Ju, Yehong Yang, Hao Wang, Wenjie Chen, Xuelan Zhao, Hongying Ye, Yu Zhang
Introduction: Diabetic cardiomyopathy is characterized by an imbalance between myocyte death and regeneration mediated by the progressive loss of cardiac stem and progenitor cells (CSPCs) by apoptosis and necrosis due to the activation of oxidative stress with diabetes. In this study, we evaluated the beneficial effect of astragalus polysaccharides (APS) therapy on the protection of CSPCs through its antioxidative capacity in diabetic hearts. Materials and methods: Streptozotocin (STZ)-induced diabetic mice and heterozygous (SOD2+/-) knockout mice were employed and administered with APS...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29713833/astragalus-affects-fecal-microbial-composition-of-young-hens-as-determined-by-16s-rrna-sequencing
#7
Hongxing Qiao, Liheng Zhang, Hongtao Shi, Yuzhen Song, Chuanzhou Bian
The gut microbiota play important roles in the degradation of chemical compounds of herbal medicines (HMs). However, little information regarding the interplay between HMs and the gut microbiota is available. Thus, the aim of this study was to investigate the composition of the fecal microbiota of young (age, 11 weeks) hens fed a conventional diet containing a crude Astragalus (0.5%) additive for 21 days (group A) vs. controls (group B) that were fed only conventional feed. The fecal contents of 14-week-old hens were collected for DNA extraction, and then the V3 and V4 hyper-variable regions of the 16S rRNA gene were amplified and analyzed using high-throughput sequencing technology...
April 30, 2018: AMB Express
https://www.readbyqxmd.com/read/29703390/concurrent-administration-of-anticancer-chemotherapy-drug-and-herbal-medicine-on-the-perspective-of-pharmacokinetics
#8
REVIEW
Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer drugs with traditional herbs is rare. Pharmacokinetic investigations are an efficient way to understand the influence of concomitant remedies. Therefore, this study aimed to collect the results of pharmacokinetic studies relating to the concurrent use of cancer chemotherapy and complementary and alternative therapies...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29700792/preventive-effect-of-shenkang-injection-against-high-glucose-induced-senescence-of-renal-tubular-cells
#9
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
Shenkang injection (SKI) is a classic prescription composed of Radix Astragali, rhubarb, Astragalus, Safflower, and Salvia. This treatment was approved by the State Food and Drug Administration of China in 1999 for treatment of chronic kidney diseases based on good efficacy and safety. This study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescence and its underlying mechanism. Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), medium containing 5 mmol/L glucose; (2) mannitol medium (mannitol group), medium containing 5 mmol/L glucose, and 25 mmol/L mannitol; (3) HG medium (HG group) containing 30 mmol/L glucose; (4) SKI treatment at high (200 mg/L), medium (100 mg/L), or low (50 mg/L) concentration in HG medium (HG + SKI group); or (5) 200 mg/L SKI treatment in control medium (control + SKI group) for 72 h...
April 25, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29696523/occurrence-of-ochratoxin-a-in-astragalus-propinquus-root-and-its-transfer-to-decoction
#10
Jakub Toman, Vladimir Ostry, Yann Grosse, Tomas Roubal, Frantisek Malir
The aim of this study was to conduct a survey assessing (a) the ochratoxin A (OTA) content in different samples of Astragalus propinquus root (AR), one of the fundamental herbs in traditional Chinese medicine, and (b) the rate of OTA transfer to AR decoctions that are traditionally used to reduce general weakness and increase overall vitality. A validated method of high-performance liquid chromatography with fluorescence detection (HPLC-FLD) was used to determine OTA concentrations in AR samples and AR decoctions...
April 25, 2018: Mycotoxin Research
https://www.readbyqxmd.com/read/29677643/biotransformation-of-cyclocanthogenol-by-the-endophytic-fungus-alternaria-eureka-1e1bl1
#11
Güner Ekiz, Seda Duman, Erdal Bedir
The microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus angustifolius was investigated. Hydroxylation, oxidation, epoxidation, O-methylation, ring-expansion and methyl migration reactions were observed on the triterpenoid skeleton. As a result, eight metabolites were isolated and the structures of the previously undescribed compounds were established by 1-D, 2-D NMR and HR-MS analyses.
April 17, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29672953/astragalus-polysaccharides-exerts-anti-infective-activity-by-inducing-human-cathelicidin-antimicrobial-peptide-ll-37-in-respiratory-epithelial-cells
#12
Lin Zhao, Shuai Tan, Hai Zhang, Peng Liu, Yu-Zhu Tan, Jia-Chuan Li, Da Jia, Xiao-Fei Shen
Astragalus polysaccharides (APS), one of the major active components in Astragalus membranaceus, is an effective immunomodulator used in the treatment of immunological diseases in China. However, the anti-infective action and mechanism of APS is not fully known. In the present study, we found that APS induced the expression of human cathelicidin antimicrobial peptide LL-37, a key host anti-infective molecule, in both mRNA and protein levels in respiratory epithelial cells HBE16 and A549. Furthermore, the lysate and supernatant from APS-treated HBE16 cells both exhibited an obvious antibacterial action, which was partially neutralizated by LL-37 monoclonal antibody...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29664452/protective-role-of-astragalus-injection-in-spinal-cord-ischemia-reperfusion-injury-in-rats
#13
Liya Zhou, Zhenfei Song, Liwen Zhou, Yongchi Qiu, Nan Hu, Yong Hu, Xingming Hu
OBJECTIVE: To investigate the neuroprotective effect of Astragalus injection in a spinal cord ischemia-reperfusion (I/R) injury model. METHODS: A total of 27 Sprague Dawley rats were randomly divided into 3 groups: control group (n=3), I/R group (n=12), and Astragalus injection group (Ast group, n=12). Spinal cord ischemia was induced by occlusion of the abdominal aorta above the right renal artery for 32 min. Animals in the Ast group were administered Astragalus injection (6...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29660466/formononetin-an-isoflavone-from-astragalus-membranaceus-inhibits-proliferation-and-metastasis-of-ovarian-cancer-cells
#14
Jing Zhang, Likun Liu, Jing Wang, Baoyin Ren, Lin Zhang, Weiling Li
ETHNOPHARMACOLOGICAL RELEVANCE: Astragalus membranaceus which was originally described in the Shennong's Classic of Materia Medica, the earliest complete Pharmacopoeia of China written from the Warring States Period to Han Dynasty, has been widely used in Chinese medicine for>2,000 years, especially in the prescription of curing cancer. A. membranaceus has various bioactivities, such as anti-tumor, anti-viral, anti-oxidant, anti-diabetes, anti-inflammation, anti-atherosclerosis, immunomodulation, hepatoprotection, hematopoiesis, neuroprotection and so on...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29655852/aidi-injection-plus-platinum-based-chemotherapy-for-stage-iiib-iv-non-small-cell-lung-cancer-a-meta-analysis-of-42-rcts-following-the-prisma-guidelines
#15
Jue Wang, Guochun Li, Lili Yu, Tingting Mo, Qibiao Wu, Zhou Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Aidi injection is one of the most commonly used Chinese patent medicines for advanced non-small cell lung cancer (NSCLC). It is made from an extraction of Mylabris Phalerata, Radix Astragalus, Radix Ginseng, and Acanthopanax Senticosus. AIM OF THE STUDY: The objective of this study is to evaluate the efficacy and safety of Aidi injection in combination with platinum-based chemotherapy for stage IIIB/IV NSCLC. MATERIALS AND METHODS: A systematic review and meta-analysis were performed following the PRISMA (the Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
April 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29649754/a-rapid-method-for-sensitive-profiling-of-bioactive-triterpene-and-flavonoid-from-astragalus-mongholicus-and-astragalus-membranaceus-by-ultra-pressure-liquid-chromatography-with-tandem-mass-spectrometry
#16
Yang Liu, Jia Liu, Ke-Xin Wu, Xiao-Rui Guo, Zhong-Hua Tang
Astragalus is one of the most popular Chinese herbal. Control of Astragalus quantity is most important, since that various varieties and ages largely affect bioactive metabolites and different pharmacological effects. Astragalus mongholicus and Astragalus membranaceus are both major sources of Astragalus according to the provisions in the Chinese Pharmacopoeia. Thus, a sensitive and rapid UPLC-MS/MS method for the simultaneous determination of l-Phenylalanine, Isoliquiritigenin, Liquiritigenin, Daidzein, Formononetin, Ononin, Calycosin, Calycosin-7-glucoside, Cycloastragenol, Astragaloside I, Astragaloside II, Astragaloside III and Astragaloside IV was established in this study...
April 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29626604/transgenerational-effects-of-paternal-dietary-astragalus-polysaccharides-on-spleen-immunity-of-broilers
#17
Yulong Li, Xinyu Lei, Zhenchen Yin, Wei Guo, Shengru Wu, Xiaojun Yang
Our previous study indicated that paternal dietary Astragalus polysaccharides (APS) could induce endotoxin tolerance-like response in jejunum of offspring chickens. There exist positive interaction between intestinal mucosal immunity and systemic immunity. So we studied the transgenerational effect and nutri-epigenetic role of paternal dietary APS on spleen immunity. 64 one-day-old Avein breeder cocks were used in a single-factor design with 0 and 10 g/kg APS, respectively, 4 replicated cages each group, and 8 birds each cage...
April 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29620230/formononetin-inhibits-colon-carcinoma-cell-growth-and-invasion-by-microrna%C3%A2-149%C3%A2-mediated-ephb3-downregulation-and-inhibition-of-pi3k-akt-and-stat3-signaling-pathways
#18
Ai-Lei Wang, Yong Li, Qun Zhao, Li-Qiao Fan
Formononetin (Form), a phytoestrogen extracted from the roots of Astragalus membranaceus, is one of the fundamental herbs used in traditional Chinese medicine because of its protective effects against certain malignant tumors. However, its role in colon carcinoma cells and the underlying molecular mechanisms have not been completely elucidated. The present study aimed to demonstrate that Form significantly inhibited the proliferation and invasion of the colon carcinoma cell lines SW1116 and HCT116. Mechanistic studies have suggested that Form suppresses colon carcinoma cell growth by downregulating cell cycle‑associated protein (cyclin D1) expression and arresting the cell cycle at the G0‑G1 checkpoint...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29619068/-astragalus-membranaceus-and-salvia-miltiorrhiza-ameliorate-lipopolysaccharide-induced-acute-lung-injury-in-rats-by-regulating-the-toll-like-receptor-4-nuclear-factor-kappa-b-signaling-pathway
#19
Li Qin, Hong-Ling Tan, Yu-Guo Wang, Cheng-Yong Xu, Jian Feng, Min Li, Yong-Qi Dou
Astragalus membranaceus and Salvia miltiorrhiza (AM/SM) are well used in Traditional Chinese Medicines (TCM) for nourishing Qi and activating blood circulation method. From TCM theory, the pathogenesis of acute lung injury (ALI) was determined as Qi deficiency and blood stagnation. In this study, we are aiming to investigate the protective and therapeutic effects of AM/SM on a rat model of lipopolysaccharide- (LPS-) induced ALI in rats and to elucidate potential molecular mechanisms. ALI was induced by intratracheal instillation of LPS (5 mg/kg) in Sprague-Dawley rats...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29607874/astraglaus-polysaccharide-protects-diabetic-cardiomyopathy-by-activating-nrg1-erbb-pathway
#20
Xiao Chang, Kang Lu, Ling Wang, Min Lv, Wenjun Fu
Diabetic cardiomyopathy (DCM) is one of the main cardiac complications among diabetic patients. According to previous studies, the pathogenesis of DCM is associated with oxidative stress, apoptosis and proliferation of local cardiac cells. It showed, NRG1 can improve the function of mitochondria, and thereby, increasing proliferation and decreasing apoptosis of cardiac muscle cell via ErbB/AKT signaling, also, exert antioxidative function. Besides, NRG1/ErbB pathway was impaired in the DCM model which suggested this signaling played key role in DCM...
April 2, 2018: Bioscience Trends
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