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https://www.readbyqxmd.com/read/28320720/moraxella-species-as-potential-sources-of-mcr-like-polymyxin-resistance-determinants
#1
Nicolas Kieffer, Patrice Nordmann, Laurent Poirel
Plasmid-mediated resistance to polymyxins mediated by the MCR-1/-2 determinants has been recently reported in Enterobacteriaceae worldwide. Using PCR-based and cloning strategies, a series of Moraxella species were screened for mcr-like genes. Moraxella spp. that are mainly animal pathogens but may also be human pathogens were identified as potential reservoirs of mcr-like genes.
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28316780/screening-for-fecal-carriage-of-mcr-producing-enterobacteriaceae-in-healthy-humans-and-primary-care-patients
#2
Katrin Zurfluh, Roger Stephan, Andreas Widmer, Laurent Poirel, Patrice Nordmann, Hans-Jakob Nüesch, Herbert Hächler, Magdalena Nüesch-Inderbinen
BACKGROUND: The extent of the occurrence of the plasmid-encoded colistin resistance genes mcr-1 and mcr-2 among humans is currently sparsely studied in Western Europe. OBJECTIVES: To determine the occurrence of MCR-producing Enterobacteriaceae in fecal samples of healthy humans with high occupational exposure to food and primary care patients in Switzerland. METHODS: Stool samples from 1091 healthy individuals and fecal swabs from 53 primary care patients were screened for polymyxin-resistant Enterobacteriaceae using LB agar containing 4 mg/L colistin...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28287910/transferability-of-the-mcr-1-colistin-resistance-gene
#3
Valérie Dénervaud Tendon, Laurent Poirel, Patrice Nordmann
No abstract text is available yet for this article.
March 13, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28276793/lack-of-polymyxin-resistance-among-carbapenemase-producing-enterobacteriaceae-in-a-university-hospital-in-china
#4
Xiaofei Jiang, Laurent Poirel, Patrice Nordmann
No abstract text is available yet for this article.
March 3, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28275006/polymyxins-antibacterial-activity-susceptibility-testing-and-resistance-mechanisms-encoded-by-plasmids-or-chromosomes
#5
REVIEW
Laurent Poirel, Aurélie Jayol, Patrice Nordmann
SUMMARYPolymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin-resistant bacteria...
April 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28143782/esbl-ampc-and-carbapenemase-producing-enterobacteriaceae-in-animals-a-threat-for-humans
#6
REVIEW
Jean-Yves Madec, Marisa Haenni, Patrice Nordmann, Laurent Poirel
There has been a great and long-term concern that ESBL/AmpC- and carbapenemase-producing Enterobacteriaceae occurring in animals may constitute a public health issue. A large number of factors with complex interrelations contribute to the spread of those bacteria among animals and humans. ESBL/AmpC- or carbapenemase-encoding genes are most often located onto mobile genetic elements favouring their dissemination. Some shared reservoirs of ESBL/AmpC or carbapenemase genes, plasmids or clones have been identified and suggest cross-transmissions...
January 28, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28135893/recent-advances-in-biochemical-and-molecular-diagnostics-for-the-rapid-detection-of-antibiotic-resistant-enterobacteriaceae-a-focus-on-%C3%A3-lactam-resistance
#7
Jean-Winoc Decousser, Laurent Poirel, Patrice Nordmann
The rapid detection of resistance is a challenge for clinical microbiologists who wish to prevent deleterious individual and collective consequences such as (i) delaying efficient antibiotic therapy, which worsens the survival rate of the most severely ill patients, or (ii) delaying the isolation of the carriers of multidrug-resistant bacteria and promoting outbreaks; this last consequence is of special concern, and there are an increasing number of approaches and market-based solutions in response. Areas covered: From simple, cheap biochemical tests to whole-genome sequencing, clinical microbiologists must select the most adequate phenotypic and genotypic tools to promptly detect and confirm β-lactam resistance from cultivated bacteria or from clinical specimens...
February 20, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28100594/rapid-aminoglycoside-np-test-for-rapid-detection-of-multiple-aminoglycoside-resistance-in-enterobacteriaceae
#8
Patrice Nordmann, Aurélie Jayol, Jan Dobias, Laurent Poirel
The Rapid Aminoglycoside NP (Nordmann/Poirel) test was developed to rapidly identify multiple aminoglycoside (AG) resistance in Enterobacteriaceae It is based on the detection of the glucose metabolism related to enterobacterial growth in presence of a defined concentration of amikacin plus gentamicin. Formation of acid metabolites was evidenced by a color change (orange to yellow) of the red phenol pH indicator. The Rapid Aminoglycoside NP test was evaluated by using bacterial colonies of 18 AG-resistant isolates producing 16S rRNA methylases, 20 AG-resistant isolates expressing AG-modifying enzymes (acetyl, adenyl and phospho transferases), and 10 isolates susceptible to AG...
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28069656/characterization-of-brpmbl-the-bleomycin-resistance-protein-associated-with-the-carbapenemase-ndm
#9
Laurent Dortet, Delphine Girlich, Anne-Laure Virlouvet, Laurent Poirel, Patrice Nordmann, Bogdan I Iorga, Thierry Naas
The metallo-β-lactamase NDM-1 is among the most worrisome resistance determinants and is spreading worldwide among Gram-negative bacilli. A bleomycin resistance gene, bleMBL, downstream of the blaNDM-1 gene has been associated with resistance almost systematically. Here, we characterized the corresponding protein, BRPMBL, conferring resistance to bleomycin, an antitumoral glycopeptide molecule. We have determined whether the expression of the blaNDM-1-bleMBL operon is inducible in the presence of carbapenems and/or bleomycin-like molecules using quantitative reverse transcription-PCR (qRT-PCR), determination of imipenem and zeocin MICs, and carbapenemase-specific activity assays...
March 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27866944/occurrence-of-carbapenemase-producing-klebsiella-pneumoniae-and-escherichia-coli-in-the-european-survey-of-carbapenemase-producing-enterobacteriaceae-euscape-a-prospective-multinational-study
#10
Hajo Grundmann, Corinna Glasner, Barbara Albiger, David M Aanensen, Chris T Tomlinson, Arjana Tambić Andrasević, Rafael Cantón, Yehuda Carmeli, Alexander W Friedrich, Christian G Giske, Youri Glupczynski, Marek Gniadkowski, David M Livermore, Patrice Nordmann, Laurent Poirel, Gian M Rossolini, Harald Seifert, Alkiviadis Vatopoulos, Timothy Walsh, Neil Woodford, Dominique L Monnet
BACKGROUND: Gaps in the diagnostic capacity and heterogeneity of national surveillance and reporting standards in Europe make it difficult to contain carbapenemase-producing Enterobacteriaceae. We report the development of a consistent sampling framework and the results of the first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in European hospitals. METHODS: National expert laboratories recruited hospitals with diagnostic capacities, who collected the first ten carbapenem non-susceptible clinical isolates of K pneumoniae or E coli and ten susceptible same-species comparator isolates and pertinent patient and hospital information...
2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27685838/national-survey-of-colistin-resistance-among-carbapenemase-producing-enterobacteriaceae-and-outbreak-caused-by-colistin-resistant-oxa-48-producing-klebsiella-pneumoniae-france-2014
#11
Aurélie Jayol, Laurent Poirel, Laurent Dortet, Patrice Nordmann
From January 2014 to December 2014, 972 consecutive non-replicate carbapenemase-producing Enterobacteriaceae isolates from colonised or infected patients were collected at the Associated French National Reference Centre as part of the French national survey on antimicrobial resistance. It included 577 Klebsiella spp. (59%), 236 Escherichia coli (24%), 108 Enterobacter spp. (11%), 50 Citrobacter spp. (5%), and a single Salmonella spp. isolate (0.1%). Of 561 K. pneumoniae isolates, 35 were found to be resistant to colistin (6...
September 15, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27671060/crystal-structure-of-the-pseudomonas-aeruginosa-bel-1-extended-spectrum-%C3%AE-lactamase-and-its-complexes-with-moxalactam-and-imipenem
#12
Cecilia Pozzi, Filomena De Luca, Manuela Benvenuti, Laurent Poirel, Patrice Nordmann, Gian Maria Rossolini, Stefano Mangani, Jean-Denis Docquier
BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes). This enzyme is efficiently inhibited by clavulanate, imipenem, and moxalactam. Crystals of BEL-1 were obtained at pH 5.6, and the structure of native BEL-1 was determined from orthorhombic and monoclinic crystal forms at 1.60-Å and 1.48-Å resolution, respectively. By soaking native BEL-1 crystals, complexes with imipenem (monoclinic form, 1...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27671058/transposition-of-tn125-encoding-the-ndm-1-carbapenemase-in-acinetobacter-baumannii
#13
Séverine Bontron, Patrice Nordmann, Laurent Poirel
The blaNDM-1 gene encodes a carbapenemase that confers resistance to almost all β-lactams, including last-resort carbapenems. This is increasingly reported worldwide in nosocomial and community-acquired Gram-negative bacteria. Acinetobacter baumannii is an important opportunistic pathogen that is considered an intermediate reservoir for the blaNDM-1 gene. In this species, the blaNDM-1 gene is located within the Tn125 composite transposon. The mechanism driving the mobility of Tn125 has not yet been elucidated...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27544715/very-low-prevalence-of-mcr-1-mcr-2-plasmid-mediated-colistin-resistance-in-urinary-tract-enterobacteriaceae-in-switzerland
#14
Nadia Liassine, Laetititia Assouvie, Marie-Christine Descombes, Valérie Dénervaud Tendon, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann
No abstract text is available yet for this article.
August 17, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27527082/features-of-the-mcr-1-cassette-related-to-colistin-resistance
#15
LETTER
Katrin Zurfluh, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann, Roger Stephan
No abstract text is available yet for this article.
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27504841/occurrence-and-features-of-chromosomally-encoded-carbapenemases-in-gram-negative-bacteria-in-farm-animals-sampled-at-slaughterhouse-level
#16
K Zurfluh, D Hindermann, M Nüesch-Inderbinen, L Poirel, P Nordmann, R Stephan
No abstract text is available yet for this article.
June 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27503638/high-prevalence-of-carbapenemase-producing-enterobacteriaceae-among-hospitalized-children-in-luanda-angola
#17
Nicolas Kieffer, Patrice Nordmann, Marta Aires-de-Sousa, Laurent Poirel
This study aimed to evaluate the prevalence of carbapenemase-producing Enterobacteriaceae in Luanda, Angola. A total of 157 rectal samples were collected from children visiting a pediatric hospital in Luanda in March 2015. Fifty-seven imipenem-nonsusceptible enterobacterial isolates were recovered, most of which were non-clonally related. The blaOXA-181 (50/57) and blaNDM-1 (7/57) carbapenemase genes were identified. Notably, OXA-181-producing Escherichia coli isolates rarely coproduced extended-spectrum β-lactamases and consequently remained susceptible to broad-spectrum cephalosporins...
October 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27491979/draft-genome-sequence-of-escherichia-coli-s51-a-chicken-isolate-harboring-a-chromosomally-encoded-mcr-1-gene
#18
Katrin Zurfluh, Taurai Tasara, Laurent Poirel, Patrice Nordmann, Roger Stephan
We present the draft genome of Escherichia coli S51, a colistin-resistant extended-spectrum β-lactamase-producing strain isolated in 2015 from raw chicken meat imported from Germany. Assembly and annotation of this draft genome resulted in a 4,994,918-bp chromosome and revealed a chromosomally encoded mcr-1 gene responsible for the colistin resistance of the strain.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27307457/rapid-detection-of-polymyxin-resistant-enterobacteriaceae-from-blood-cultures
#19
Aurélie Jayol, Véronique Dubois, Laurent Poirel, Patrice Nordmann
Enterobacterial strains resistant to polymyxins are being increasingly reported worldwide. The conventional methods for detection of colistin-resistant isolates such as broth microdilution remain time-consuming (24 to 48 h), and methods such as disc diffusion and Etest are not reliable. Recently, the rapid polymyxin NP test was developed for rapid identification of polymyxin-resistant Enterobacteriaceae This test is based on the detection of glucose metabolism related to bacterial growth in the presence of a defined concentration of colistin (or polymyxin B)...
September 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27191712/rapid-detection-of-polymyxin-resistance-in-enterobacteriaceae
#20
Patrice Nordmann, Aurélie Jayol, Laurent Poirel
For identification of polymyxin resistance in Enterobacteriaceae, we developed a rapid test that detects glucose metabolization associated with bacterial growth in the presence of a defined concentration of colistin or polymyxin B. Formation of acid metabolites is evidenced by a color change (orange to yellow) of a pH indicator (red phenol). To evaluate the test, we used bacterial colonies of 135 isolates expressing various mechanisms of colistin resistance (intrinsic, chromosomally encoded, and plasmid-mediated MCR-1) and 65 colistin-susceptible isolates...
June 2016: Emerging Infectious Diseases
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