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https://www.readbyqxmd.com/read/29311060/transposition-of-tn1213-encoding-the-per-1-extended-spectrum-%C3%AE-lactamase
#1
Stefano Mancini, Laurent Poirel, Nicolas Kieffer, Patrice Nordmann
PER-1 is an extended-spectrum β-lactamase that is encoded by a gene located into the composite transposon Tn1213 made by two distinct insertion sequences, namely ISPa12 and ISPa13 In vitro mobilization performed in Escherichia coli shows that Tn1213 is functional and is able to mobilize the blaPER-1 gene although at a very low frequency (ca 1x10-9).
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29198372/klebsiella-pneumoniae-co-producing-kpc-and-rmtg-finally-targeting-switzerland
#2
Stefano Mancini, Laurent Poirel, Myriam Corthesy, Gilbert Greub, Patrice Nordmann
A carbapenem- and pan-aminoglycoside-resistant Klebsiella pneumoniae strain was isolated from a Brazilian patient hospitalized in a Swiss hospital. The clinical isolate carried genes encoding the KPC-2 carbapenemase and the RmtG 16S rRNA methyltransferase. This is the first report of a carbapenem-resistant K. pneumoniae producing RmtG in Europe.
November 6, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29194479/emergence-of-an-mdr-klebsiella-pneumoniae-st231-producing-oxa-232-and-rmtf-in-switzerland
#3
Stefano Mancini, Laurent Poirel, Marie-Lise Tritten, Reto Lienhard, Cécile Bassi, Patrice Nordmann
No abstract text is available yet for this article.
November 29, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29165563/ceftazidime-avibactam-alone-or-in-combination-with-aztreonam-against-colistin-resistant-and-carbapenemase-producing-klebsiella-pneumoniae
#4
Aurélie Jayol, Patrice Nordmann, Laurent Poirel, Véronique Dubois
No abstract text is available yet for this article.
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29150373/chromagar-msupercarba-and-rapidec%C3%A2-carba-np-test-for-detection-of-carbapenemase-producing-enterobacteriaceae
#5
Meritxell Garcia-Quintanilla, Laurent Poirel, Patrice Nordmann
A novel chromogenic medium CHROMagar mSuperCARBA was evaluated to detect carbapenem-resistant Gram-negatives. This medium is as sensitive and as specific as the SUPERCARBA medium for detecting KPC, MBL and OXA-48-type producers (100% and 100%, respectively) and is compatible with subsequent testing of carbapenemase activity using the RAPIDEC(®) CARBA NP.
October 19, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29148380/high-rate-of-mcr-1-producing-escherichia-coli-and-klebsiella-pneumoniae-among-pigs-portugal
#6
Nicolas Kieffer, Marta Aires-de-Sousa, Patrice Nordmann, Laurent Poirel
The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1-producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29146285/rapid-polymyxin-np-test-for-the-detection-of-polymyxin-resistance-mediated-by-the-mcr-1-mcr-2-genes
#7
Laurent Poirel, Yu Larpin, Jan Dobias, Roger Stephan, Jean-Winoc Decousser, Jean-Yves Madec, Patrice Nordmann
The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR-1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains either recovered from the environment, animals, or humans. Sensitivity and specificity were found to be 100%.
September 22, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29091226/plazomicin-activity-against-polymyxin-resistant-enterobacteriaceae-including-mcr-1-producing-isolates
#8
Valérie Denervaud-Tendon, Laurent Poirel, Lynn E Connolly, Kevin M Krause, Patrice Nordmann
Objectives: Plazomicin, a novel aminoglycoside with in vitro activity against MDR Gram-negative organisms, is under development to treat patients with serious enterobacterial infections. We evaluated the activity of plazomicin and comparators against colistin-resistant enterobacterial isolates. Methods: Susceptibility to plazomicin and comparators was tested by broth microdilution for a collection of 95 colistin-resistant enterobacterial isolates collected from 29 hospitals in eight countries...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29091193/mcr-2-mediated-plasmid-borne-polymyxin-resistance-most-likely-originates-from-moraxella-pluranimalium
#9
Laurent Poirel, Nicolas Kieffer, José F Fernandez-Garayzabal, Ana Isabel Vela, Yu Larpin, Patrice Nordmann
No abstract text is available yet for this article.
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28978685/detection-of-colistin-resistant-mcr-1-positive-escherichia-coli-using-inhibition-by-edta-and-zeta-potential-assays
#10
Fernanda Esposito, Miriam R Fernandes, Ralf Lopes, Maria Muñoz, Caetano P Sabino, Marcos P Cunha, Ketrin C Silva, Rodrigo Cayô, Willames M Martins, Andrea M Moreno, Terezinha Knöbl, Ana C Gales, Nilton Lincopan
The emergence and rapid dissemination of colistin-resistant Escherichia coli carrying the plasmid-mediated mcr-1 gene has created an urgent need to develop specific screening methods. In this study, we evaluate four assays based on the inhibition of the MCR-1 activity by EDTA: i) a combined disk test (CDT) comparing the inhibition zones of colistin (10 μg) and colistin-plus-EDTA (10 μg-plus-100 mM); ii) reduction of colistin MIC (CMR) in the presence of EDTA (80 μg/mL); iii) a modified rapid polymyxin Nordmann/Poirel test (MPNP) and; iv) alteration of Zeta potential (RZP= ZP+EDTA/ZP-EDTA)...
October 4, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28966489/evaluation-of-nordmann-dortet-and-poirel-test-for-the-identification-of-extended-spectrum-betalactamase-production-among-urinary-isolates-of-escherichia-coli
#11
R Deepa, Mythry Ravichandran, S Thasneem Banu, R Sharmila
CONTEXT: Current phenotypic techniques for extended spectrum beta lactamase (ESBL) detection can be interpreted after 24 h of incubation only, resulting in a delay in initiating therapy. Nordmann, Dortet, and Poirel (NDP) in 2012 proposed a novel test named ESBL NDP to overcome this limitation. AIMS: This study aimed to evaluate the ESBL NDP test for the identification of ESBL among Escherichia coli isolates against the Clinical Laboratory Standards Institute-recommended phenotypic confirmatory method...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28878890/key-features-of-mcr-1-bearing-plasmids-from-escherichia-coli-isolated-from-humans-and-food
#12
Katrin Zurfluh, Magdalena Nüesch-Inderbinen, Jochen Klumpp, Laurent Poirel, Patrice Nordmann, Roger Stephan
BACKGROUND: Mcr-1-harboring Enterobacteriaceae are reported worldwide since their first discovery in 2015. However, a limited number of studies are available that compared full-length plasmid sequences of human and animal origins. METHODS: In this study, mcr-1-bearing plasmids from seven Escherichia coli isolates recovered from patients (n = 3), poultry meat (n = 2) and turkey meat (n = 2) in Switzerland were further analyzed and compared. Isolates were characterized by multilocus sequence typing (MLST)...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28874377/high-level-resistance-to-colistin-mediated-by-various-mutations-in-the-crrb-gene-among-carbapenemase-producing-klebsiella-pneumoniae
#13
Aurélie Jayol, Patrice Nordmann, Adrian Brink, Maria-Virginia Villegas, Véronique Dubois, Laurent Poirel
Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the susceptibility to colistin in all cases, confirming the involvement of the identified substitutions in the resistance phenotype...
November 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28748397/activity-of-the-novel-siderophore-cephalosporin-cefiderocol-against-multidrug-resistant-gram-negative-pathogens
#14
J Dobias, V Dénervaud-Tendon, L Poirel, P Nordmann
The novel siderophore cephalosporin cefiderocol (S-649266) with potent activity against Gram-negative pathogens was recently developed (Shionogi & Co., Ltd.). Here, we evaluated the activity of this new molecule and comparators against a collection of previously characterized Gram-negative isolates using broth microdilution panels. A total of 753 clinical multidrug-resistant Gram-negative isolates collected from hospitals worldwide were tested against cefiderocol and antibiotic comparators (ceftolozane-tazobactam [CT], meropenem [MEM], ceftazidime [CAZ], ceftazidime-avibactam [CZA], colistin [CST], aztreonam [ATM], amikacin [AMK], ciprofloxacin [CIP], cefepime [FEP], and tigecycline [TGC]) for their susceptibility...
December 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28747375/evaluation-of-the-rapid-polymyxin-np-test-for-polymyxin-b-resistance-detection-using-enterobacter-cloacae-and-enterobacter-aerogenes-isolates
#15
Shelby Simar, Diane Sibley, Deborah Ashcraft, George Pankey
Polymyxin resistance is an increasing problem worldwide. Currently, determining susceptibility to polymyxins is problematic and lengthy. Polymyxins diffuse poorly into agar, potentially giving inaccurate disk diffusion and Etest results. A rapid screening test (2 h) for the detection of polymyxin resistance in Enterobacteriaceae, developed by P. Nordmann and L. Poirel (rapid polymyxin NP test) in 2016, detects glucose metabolization in the presence of polymyxin E (PE) and PB via pH-induced color change. The sensitivity and specificity were 99...
October 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28606644/comparison-of-methods-for-detection-of-plasmid-mediated-and-chromosomally-encoded-colistin-resistance-in-enterobacteriaceae
#16
A Jayol, P Nordmann, P Lehours, L Poirel, V Dubois
OBJECTIVES: Because of the emergence of plasmid-mediated (mcr-1 and mcr-2 genes) and chromosomally encoded colistin resistance, reliable methods for detecting colistin resistance/susceptibility in routine laboratories are required. We evaluated the respective performances of the BD Phoenix automated system, the newly developed Rapid Polymyxin NP test and the broth microdilution (BMD) reference method to detect colistin resistance in Enterobacteriaceae, and particularly those producing mcr-1 and mcr-2...
June 9, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28598315/prevalence-of-faecal-carriage-of-colistin-resistant-gram-negative-rods-in-a-university-hospital-in-western-france-2016
#17
Marion Saly, Aurelie Jayol, Laurent Poirel, Francis Megraud, Patrice Nordmann, Veronique Dubois
Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university hospital in western France. From February to May 2016, rectal swabs from 653 patients hospitalized in various clinical settings were recovered and subsequently screened for colistin resistance using the SuperPolymyxin medium. Antimicrobial susceptibilities were determined according to EUCAST guidelines...
June 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28586429/hafnia-an-enterobacterial-genus-naturally-resistant-to-colistin-revealed-by-three-susceptibility-testing-methods
#18
Aurélie Jayol, Marion Saly, Patrice Nordmann, Armelle Ménard, Laurent Poirel, Véronique Dubois
Objectives: To determine the susceptibility to colistin of Hafnia alvei and Hafnia paralvei, and to compare methods for colistin resistance detection in the Hafnia genus. Methods: A collection of 25 Hafnia isolates was studied. Species were identified by using 16S rRNA gene sequencing with subsequent phylogeny analysis. Susceptibility to colistin was determined using the broth microdilution (BMD) reference method, the Phoenix automated system, the Rapid Polymyxin NP test, the Etest system and the disc diffusion method...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28533001/evaluation-of-the-rapidec%C3%A2-carba-np-and-%C3%AE-carba%C3%A2-tests-for-rapid-detection-of-carbapenemase-producing-enterobacteriaceae
#19
Stefano Mancini, Nicolas Kieffer, Laurent Poirel, Patrice Nordmann
The analytical performances of the RAPIDEC CARBA NP® (bioMérieux) and the β-CARBA® (Bio-Rad) tests were evaluated for the rapid detection of any known type of carbapenemases in Enterobacteriaceae. An international collection of 149 enterobacterial isolates comprising 111 Carbapenemase-Producing Enterobacteriaceae (CPE) and 38 non-carbapenemase producers was used. CPE included 32 carbapenemase producers of class A (18 KPC-2, 1 FRI-1, 5 SME and 8 IMI), 33 of class B (13 NDM, 11 VIM and 9 IMP) and 46 of class D (15 OXA-48, 14 OXA-181, 10 OXA-204, 3 OXA-232 and 4 OXA-162)...
May 13, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28479312/a-modified-esbl-nordmann-dortet-poirel-based-protocol-to-optimize-early-sepsis-management
#20
Jorge Arca-Suárez, Fátima Galán-Sánchez, César Del Prado Montoro, Manuel A Rodríguez-Iglesias
We evaluated a modification of a colorimetric test recently described by Dortet et al. (2015) for the rapid detection of ESBL-producing Enterobacteriaceae directly from positive blood cultures that requires less manipulation, materials and hands-on time. The simplified protocol showed a sensitivity and specificity of 100% and 95.7% respectively.
August 2017: Journal of Microbiological Methods
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