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Laxminarayan

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https://www.readbyqxmd.com/read/28009290/inhibition-of-ror%C3%AE-t-skews-tcr%C3%AE-gene-rearrangement-and-limits-t-cell-repertoire-diversity
#1
Yanxia Guo, Kenzie D MacIsaac, Yi Chen, Richard J Miller, Renu Jain, Barbara Joyce-Shaikh, Heidi Ferguson, I-Ming Wang, Razvan Cristescu, John Mudgett, Laura Engstrom, Kyle J Piers, Gretchen A Baltus, Kenneth Barr, Hongjun Zhang, Huseyin Mehmet, Laxminarayan G Hegde, Xiao Hu, Laura L Carter, Thomas D Aicher, Gary Glick, Dennis Zaller, Abbas Hawwari, Craig C Correll, Dallas C Jones, Daniel J Cua
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4(+)CD8(+) (DP) thymocytes. While RORγ antagonists are currently being developed to treat autoimmunity, it remains unclear how RORγT inhibition may impact thymocyte development. In this study, we show that in addition to regulating DP thymocytes survival, RORγT also controls genes that regulate thymocyte migration, proliferation, and T cell receptor (TCR)α selection...
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/27959471/lumbar-sympathectomy-techniques-for-critical-lower-limb-ischaemia-due-to-non-reconstructable-peripheral-arterial-disease
#2
REVIEW
Veena Kl Karanth, Tulasi Kota Karanth, Laxminarayan Karanth
BACKGROUND: Critical lower limb ischaemia (CLI) is a manifestation of peripheral arterial disease (PAD) that is seen in patients with typical chronic ischaemic rest pain or patients with ischaemic skin lesions - ulcers or gangrene - for longer than 2 weeks. Critical lower limb ischaemia is the most severe form of PAD, and interventions to improve arterial perfusion become necessary. Although surgical bypass has been the gold standard for revascularisation, the extent or the site of disease may be such that the artery cannot be reconstructed or bypassed...
December 13, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27915108/how-should-we-respond-to-the-emergence-of-plasmid-mediated-colistin-resistance-in-humans-and-animals
#3
REVIEW
Jaffar A Al-Tawfiq, Ramanan Laxminarayan, Marc Mendelson
OBJECTIVE: The widespread use of antibiotics in humans and animals has contributed to growing rates of antibiotic resistance. Previously treatable bacterial infections now require the last line of antibiotics or are untreatable. The current antibiotic of last resort for carbapenem-resistant Gram-negative bacterial infections is often colistin. Evidence for the shifting pattern of colistin resistance and how the international community should respond are discussed in this review. METHODS: The literature on colistin resistance was reviewed...
January 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27856730/multidrug-and-carbapenem-resistant-pseudomonas-aeruginosa-in-children-united-states-1999-2012
#4
Latania K Logan, Sumanth Gandra, Siddhartha Mandal, Eili Y Klein, Jordan Levinson, Robert A Weinstein, Ramanan Laxminarayan
BACKGROUND: Pseudomonas aeruginosa is a common cause of healthcare-associated infection. Multidrug-resistant (MDR) (>3 classes) and carbapenem-resistant (CR) P aeruginosa are significant threats globally. We used a large reference-laboratory database to study the epidemiology of P aeruginosa in children in the United States. METHODS: Antimicrobial susceptibility data from the Surveillance Network were used to phenotypically identify MDR and CR P aeruginosa isolates in children aged 1 to 17 years between January 1999 and July 2012...
November 16, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27748306/current-costs-projected-financial-needs-of-india-s-universal-immunization-programme
#5
Susmita Chatterjee, Manish Pant, Pradeep Haldar, Mahesh Kumar Aggarwal, Ramanan Laxminarayan
BACKGROUND & OBJECTIVES: India's Universal Immunization Programme (UIP) is one of the largest programmes in the world in terms of quantities of vaccines administered, number of beneficiaries, number of immunization sessions, and geographical extent and diversity of areas covered. Strategic planning for the Programme requires credible information on the cost of achieving the objectives and the financial resources needed at national, State, and district levels. We present here expenditures on immunization services in India in 2012 (baseline) and projected costs for five years (2013-2017)...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27717858/poverty-and-prevalence-of-antimicrobial-resistance-in-invasive-isolates
#6
Gerardo Alvarez-Uria, Sumanth Gandra, Ramanan Laxminarayan
OBJECTIVES: To evaluate the association between the income status of a country and the prevalence of antimicrobial resistance (AMR) in the three most common bacteria causing infections in hospitals and in the community: third-generation cephalosporin (3GC)-resistant Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), and 3GC-resistant Klebsiella species. METHODS: Using 2013-2014 country-specific data from the ResistanceMap repository and the World Bank, the association between the prevalence of AMR in invasive samples and the gross national income (GNI) per capita was investigated through linear regression with robust standard errors...
November 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27647658/a-global-antimicrobial-conservation-fund-for-low-and-middle-income-countries
#7
Marc Mendelson, Osman A Dar, Steven J Hoffman, Ramanan Laxminarayan, Mirfin M Mpundu, John-Arne Røttingen
No abstract text is available yet for this article.
September 16, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27633421/antimicrobial-resistance-a-threat-to-neonate-survival
#8
Ramanan Laxminarayan, Zulfiqar A Bhutta
No abstract text is available yet for this article.
October 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27614366/reduced-burden-of-childhood-diarrheal-diseases-through-increased-access-to-water-and-sanitation-in-india-a-modeling-analysis
#9
Arindam Nandi, Itamar Megiddo, Ashvin Ashok, Amit Verma, Ramanan Laxminarayan
Each year, more than 300,000 children in India under the age of five years die from diarrheal diseases. Clean piped water and improved sanitation are known to be effective in reducing the mortality and morbidity burden of diarrhea but are not yet available to close to half of the Indian population. In this paper, we estimate the health benefits (reduced cases of diarrheal incidence and deaths averted) and economic benefits (measured by out-of-pocket treatment expenditure averted and value of insurance gained) of scaling up the coverage of piped water and improved sanitation among Indian households to a near-universal 95% level...
August 31, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27604934/use-antimicrobials-wisely
#10
Peter S Jørgensen, Didier Wernli, Scott P Carroll, Robert R Dunn, Stephan Harbarth, Simon A Levin, Anthony D So, Maja Schlüter, Ramanan Laxminarayan
No abstract text is available yet for this article.
8, 2016: Nature
https://www.readbyqxmd.com/read/27549404/antibiotic-resistance-mitigation-opportunities-in-livestock-sector-development
#11
T P Robinson, D P Bu, J Carrique-Mas, E M Fèvre, M Gilbert, D Grace, S I Hay, J Jiwakanon, M Kakkar, S Kariuki, R Laxminarayan, J Lubroth, U Magnusson, P Thi Ngoc, T P Van Boeckel, M E J Woolhouse
No abstract text is available yet for this article.
January 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27540009/achieving-global-targets-for-antimicrobial-resistance
#12
Ramanan Laxminarayan, Devi Sridhar, Martin Blaser, Minggui Wang, Mark Woolhouse
No abstract text is available yet for this article.
August 26, 2016: Science
https://www.readbyqxmd.com/read/27522002/trends-in-antibiotic-resistance-among-major-bacterial-pathogens-isolated-from-blood-cultures-tested-at-a-large-private-laboratory-network-in-india-2008-2014
#13
Sumanth Gandra, Nestor Mojica, Eili Y Klein, Ashvin Ashok, Vidya Nerurkar, Mamta Kumari, Uma Ramesh, Sunanda Dey, Viral Vadwai, Bibhu R Das, Ramanan Laxminarayan
OBJECTIVE: There have been no long-term studies on trends in antibiotic resistance (ABR) on a national scale in India. Using a private laboratory network, the ABR patterns of organisms most commonly associated with bacteremia, obtained from patients across India between 2008 and 2014, were examined. METHODS: A retrospective study of patient blood cultures collected over a 7-year period (January 1, 2008-December 31, 2014) was conducted. Data on the microorganism(s) identified and their antimicrobial susceptibility were obtained from SRL Diagnostics (Mumbai, India)...
September 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27479554/un-high-level-meeting-on-antimicrobials-what-do-we-need
#14
Ramanan Laxminarayan, Carlos F Amábile-Cuevas, Otto Cars, Timothy Evans, David L Heymann, Steven Hoffman, Alison Holmes, Marc Mendelson, Devi Sridhar, Mark Woolhouse, John-Arne Røttingen
No abstract text is available yet for this article.
July 16, 2016: Lancet
https://www.readbyqxmd.com/read/27475987/antibiotic-resistance-is-the-quintessential-one-health-issue
#15
T P Robinson, D P Bu, J Carrique-Mas, E M Fèvre, M Gilbert, D Grace, S I Hay, J Jiwakanon, M Kakkar, S Kariuki, R Laxminarayan, J Lubroth, U Magnusson, P Thi Ngoc, T P Van Boeckel, M E J Woolhouse
No abstract text is available yet for this article.
July 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27454638/pedicled-oblique-para-umbilical-perforator-opup-flap-for-upper-limb-reconstruction
#16
Praveen Naduthodikayil, Laxminarayan Bhandari, Sreelesh Lalitha Sreedhar
BACKGROUND: Groin flap has been considered the workhorse flap for hand reconstruction. However it has certain drawbacks when covering defects over elbow or proximal forearm. Pedicled oblique paraumbilical perforator (OPUP) based flaps provide a good alternative in such cases. METHODS: We performed OPUP flap in 11 cases of complex upper limb reconstructions over the past one year. We report our experience with this flap. RESULTS: All flaps survived...
June 2016: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/27257501/corrigendum-to-the-global-threat-of-antimicrobial-resistance-science-for-intervention-new-microbes-new-infect-6-2015-22-29
#17
I Roca, M Akova, F Baquero, J Carlet, M Cavaleri, S Coenen, J Cohen, D Findlay, I Gyssens, O E Heuer, G Kahlmeter, H Kruse, R Laxminarayan, E Liébana, L López-Cerero, A MacGowan, M Martins, J Rodríguez-Baño, J-M Rolain, C Segovia, B Sigauque, E Tacconelli, E Wellington, J Vila
[This corrects the article DOI: 10.1016/j.nmni.2015.02.007.].
November 2015: New Microbes and New Infections
https://www.readbyqxmd.com/read/27192102/a-role-for-private-sector-laboratories-in-public-health-surveillance-of-antimicrobial-resistance
#18
Sumanth Gandra, Anjali T Merchant, Ramanan Laxminarayan
No abstract text is available yet for this article.
June 2016: Future Microbiology
https://www.readbyqxmd.com/read/27187922/reducing-stunting-in-india-what-investments-are-needed
#19
Rasmi Avula, Neha Raykar, Purnima Menon, Ramanan Laxminarayan
No abstract text is available yet for this article.
May 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27103509/treatment-of-dental-complications-in-sickle-cell-disease
#20
REVIEW
Priti Mulimani, Samir K Ballas, Adinegara B L Abas, Laxminarayan Karanth
BACKGROUND: Sickle cell disease is the most common single gene disorder and the commonest haemoglobinopathy found with high prevalence in many populations across the world. Management of dental complications in people with sickle cell disease requires special consideration for three main reasons. Firstly, dental and oral tissues are affected by the blood disorder resulting in several oro-facial abnormalities. Secondly, living with a haemoglobinopathy and coping with its associated serious consequences may result in individuals neglecting their oral health care...
2016: Cochrane Database of Systematic Reviews
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