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https://www.readbyqxmd.com/read/29145766/environmental-samples-make-soiled-bedding-sentinels-dispensable-for-hygienic-monitoring-of-ivc-reared-mouse-colonies
#1
Manuel Miller, Markus Brielmeier
Accurate knowledge of the health status of experimental animals is pivotal to high scientific and ethical standards in biomedical research. Individually ventilated cages (IVCs) are becoming the predominant system for housing laboratory mice, as they prevent cage-to-cage infections. However, this feature constitutes a major drawback for hygienic monitoring of mouse colonies, as traditional screening programs build on reliable transmission of infectious agents from experimental animals to sentinel mice commonly tested as representatives for the mouse colonies...
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/29138228/low-protein-diet-induced-hyperphagia-and-adiposity-are-modulated-through-interactions-involving-thermoregulation-motor-activity-and-protein-quality-in-mice
#2
Anne Blais, Catherine Chaumontet, Dalila Azzout-Marniche, Julien Piedcoq, Gilles Fromentin, Claire Gaudichon, Daniel Tomé, Patrick C Even
Low-protein (LP) containing diets can induce overeating in rodents and possibly in humans in an effort to meet protein requirement but the consequences on energy expenditure (EE) are unclear. The present study evaluated the changes induced by reducing dietary protein from 20% to 6%, using either soy protein or casein, on energy intake, body composition and EE in mice housed at 22°C or at 30°C (thermal-neutrality). LP feeding increased energy intake and adiposity, more in soy fed than in casein fed mice, but also increased EE thus limiting fat accumulation...
November 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29107289/disruption-of-the-homeodomain-transcription-factor-orthopedia-homeobox-otp-is-associated-with-obesity-and-anxiety
#3
Lee Moir, Elena G Bochukova, Rebecca Dumbell, Gareth Banks, Rasneer S Bains, Patrick M Nolan, Cheryl Scudamore, Michelle Simon, Kimberly A Watson, Julia Keogh, Elana Henning, Audrey Hendricks, Stephen O'Rahilly, Inês Barroso, Adrienne E Sullivan, David C Bersten, Murray L Whitelaw, Susan Kirsch, Elizabeth Bentley, I Sadaf Farooqi, Roger D Cox
OBJECTIVE: Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. METHODS: In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in a mouse line identified as part of a dominant N-ethyl-N-nitrosourea (ENU) mutagenesis screen. We characterized the metabolic and behavioral phenotype of obese mutant mice and examined changes in hypothalamic gene expression...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29101373/ecological-and-sanitary-impacts-of-bacterial-communities-associated-to-biological-invasions-in-african-commensal-rodent-communities
#4
Christophe Diagne, Maxime Galan, Lucie Tamisier, Jonathan d'Ambrosio, Ambroise Dalecky, Khalilou Bâ, Mamadou Kane, Youssoupha Niang, Mamoudou Diallo, Aliou Sow, Philippe Gauthier, Caroline Tatard, Anne Loiseau, Sylvain Piry, Mbacké Sembène, Jean-François Cosson, Nathalie Charbonnel, Carine Brouat
Changes in host-parasite ecological interactions during biological invasion events may affect both the outcome of invasions and the dynamics of exotic and/or endemic infections. We tested these hypotheses, by investigating ongoing house mouse (Mus musculus domesticus) and black rat (Rattus rattus) invasions in Senegal (West Africa). We used a 16S gene rRNA amplicon sequencing approach to study potentially zoonotic bacterial communities in invasive and native rodents sampled along two well-defined independent invasion routes...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29083162/evaluating-metabolite-related-dna-oxidation-and-adduct-damage-from-aryl-amines-using-a-microfluidic-ecl-array
#5
Itti Bist, Snehasis Bhakta, Di Jiang, Tia E Keyes, Aaron Martin, Robert J Forster, James F Rusling
Damage to DNA from the metabolites of drugs and pollutants constitutes a major human toxicity pathway known as genotoxicity. Metabolites can react with metal ions and NADPH to oxidize DNA or participate in SN2 reactions to form covalently linked adducts with DNA bases. Guanines are the main DNA oxidation sites, and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) is the initial product. Here we describe a novel electrochemiluminescent (ECL) microwell array that produces metabolites from test compounds and measures relative rates of DNA oxidation and DNA adduct damage...
November 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29062204/repertoire-of-noncoding-rnas-in-corpus-luteum-of-early-pregnancy-in-buffalo-bubalus-bubalis
#6
A Jerome, S M K Thirumaran, S N Kala
AIM: The present study was designed to identify other noncoding RNAs (ncRNAs) in the corpus luteum (CL) during early pregnancy in buffalo. MATERIALS AND METHODS: For this study, CL (n=2) from two buffalo gravid uteri, obtained from the slaughter house, was transported to laboratory after snap freezing in liquid nitrogen (-196°C). The stage of pregnancy was determined by measuring the crown-rump region of the fetus. This was followed by isolation of RNA and deep sequencing...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29061385/modified-single-prolonged-stress-reduces-cocaine-self-administration-during-acquisition-regardless-of-rearing-environment
#7
Rebecca S Hofford, Mark A Prendergast, Michael T Bardo
Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration...
February 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29049082/inhibiting-social-support-from-massage-like-stroking-increases-morphine-dependence
#8
M L Shawn Bates, Michael A Emery, Paul J Wellman, Shoshana Eitan
Our previous studies showed that altering solely the drug experience of the cage mates with which rodents are housed affects the development of morphine dependence. In this study, we used designer receptors exclusively activated by designer drugs to artificially increase or decrease the activity of peripheral dorsal root ganglia sensory neurons expressing the G-protein-coupled receptor MRGPRB4. This is because sensory MRGPRB4-expressing neurons were shown to specifically detect the sensation of massage-like stroking resulting from social grooming, which is an important affiliative social behavior in the rodent...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29033473/impact-of-atra-on-ovalbumin-and-mold-sensitized-f344-rats-and-reversal-of-health-related-implications-by-citral
#9
Ibrahim O Farah, Carlene Holt-Gray, Joseph A Cameron, Michelle Tucci, Hamed Benghuzzi
The role of retinoic acid (All Trans Retinoic Acid; ATRA) in the development of hypervitaminosis A pathophysiology is not well understood or established in the literature. As well, the role of Citral (inhibitor of retinoid function; a non-toxic chemical that exists in two forms (diethyl; C1 or cis-trans dimethyl; C2).) in the reversal of pathophysiological implications is also not ascertained under an in vivo setting. Therefore, it is hypothesized that ovalbumin exposure will sensitize the body to supra-physiologic levels of retinoic acid leading to a negative pathophysiological impact and that Citrals 1 and 2 will reverse or ameliorate the related damage to the body's pathophysiology...
March 2017: Biomedical Sciences Instrumentation
https://www.readbyqxmd.com/read/29033472/histopathological-analysis-of-the-f344-rat-lung-upon-exposure-to-retenoic-acid-ovalbumin-mold-spores-and-citral
#10
Ibrahim O Farah, Carlene Holt-Gray, Joseph A Cameron, Michelle Tucci, Hamed Benghuzzi
The paradoxical role of retinoic acid (All Trans Retinoic Acid; ATRA) in the development of allergic and/or inflammatory complications in contrast to a therapeutic modality for lung pathology is not well understood or established in the literature. As well, the role of Citral (inhibitor of retinoid function; a non-toxic chemical that exists in two forms (diethyl; C1 or cis-trans dimethyl; C2), in the reversal of retinoic acid, ovalbumin and allergic mold spore pathophysiology is also not well ascertained under an in vivo setting...
March 2017: Biomedical Sciences Instrumentation
https://www.readbyqxmd.com/read/29031549/assessment-of-social-behavior-directed-toward-sick-partners-and-its-relation-to-central-cytokine-expression-in-rats
#11
Eduardo Kenji Hamasato, Dennis Lovelock, João Palermo-Neto, Terrence Deak
Acute illness not only reduces the expression of social behavior by sick rodents, but can also lead to avoidance responses when detected by healthy, would-be social partners. When healthy animals interact with a sick partner, an intriguing question arises: does exposure to a sick conspecific elicit an anticipatory immune response that would facilitate defense against future infection? To address this question, healthy adult male Sprague-Dawley rats (N=64) were given a brief social interaction (30min) with a partner that was either sick (250μg/kg injection with lipopolysaccharide [LPS] 3h prior to test) or healthy (sterile saline injection)...
December 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28972544/assessing-monkeypox-virus-prevalence-in-small-mammals-at-the-human-animal-interface-in-the-democratic-republic-of-the-congo
#12
Jeffrey B Doty, Jean M Malekani, Lem's N Kalemba, William T Stanley, Benjamin P Monroe, Yoshinori U Nakazawa, Matthew R Mauldin, Trésor L Bakambana, Tobit Liyandja Dja Liyandja, Zachary H Braden, Ryan M Wallace, Divin V Malekani, Andrea M McCollum, Nadia Gallardo-Romero, Ashley Kondas, A Townsend Peterson, Jorge E Osorio, Tonie E Rocke, Kevin L Karem, Ginny L Emerson, Darin S Carroll
During 2012, 2013 and 2015, we collected small mammals within 25 km of the town of Boende in Tshuapa Province, the Democratic Republic of the Congo. The prevalence of monkeypox virus (MPXV) in this area is unknown; however, cases of human infection were previously confirmed near these collection sites. Samples were collected from 353 mammals (rodents, shrews, pangolins, elephant shrews, a potamogale, and a hyrax). Some rodents and shrews were captured from houses where human monkeypox cases have recently been identified, but most were trapped in forests and agricultural areas near villages...
October 3, 2017: Viruses
https://www.readbyqxmd.com/read/28967544/wild-rodents-and-shrews-are-natural-hosts-of-staphylococcus-aureus
#13
Daniel M Mrochen, Daniel Schulz, Stefan Fischer, Kathrin Jeske, Heba El Gohary, Daniela Reil, Christian Imholt, Patricia Trübe, Josef Suchomel, Emilie Tricaud, Jens Jacob, Marta Heroldová, Barbara M Bröker, Birgit Strommenger, Birgit Walther, Rainer G Ulrich, Silva Holtfreter
Laboratory mice are the most commonly used animal model for Staphylococcus aureus infection studies. We have previously shown that laboratory mice from global vendors are frequently colonized with S. aureus. Laboratory mice originate from wild house mice. Hence, we investigated whether wild rodents, including house mice, as well as shrews are naturally colonized with S. aureus and whether S. aureus adapts to the wild animal host. 295 animals of ten different species were caught in different locations over four years (2012-2015) in Germany, France and the Czech Republic...
September 22, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28948547/peptides-epigenetic-regulators-in-the-structure-of-rodents-with-a-long-and-short-lifespan
#14
V Kh Khavinson, D Yu Kormilets, A T Mar'yanovich
We have discovered motives of short-chain epigenetically active peptides in some proteins of long-lived African mole rat Heterocephalus glaber. These epigenetic regulators are located in the protein structure between lysine and arginine residues, thus facilitating their release in limited proteolysis. Some of these epigenetic regulators are not found in the proteins of short-lived species - Norway rat Rattus norvegicus and house mouse Mus musculus.
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28946315/effect-of-processing-on-the-in-vitro-and-in-vivo-protein-quality-of-red-and-green-lentils-lens-culinaris
#15
Matthew G Nosworthy, Gerardo Medina, Adam J Franczyk, Jason Neufeld, Paulyn Appah, Alphonsus Utioh, Peter Frohlich, James D House
In order to determine the effect of extrusion, baking and cooking on the protein quality of red and green lentils, a rodent bioassay was conducted and compared to an in vitro method of protein quality determination. On average, the Protein Digestibility-Corrected Amino Acid Score of red lentils (55.0) was higher than that of green lentils (50.8). Extruded lentil flour had higher scores (63.01 red, 57.09 green) than either cooked (57.40 red, 52.92 green) or baked (53.84 red, 47.14 green) flours. The average Digestible Indispensable Amino Acid Score of red lentils (0...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28916995/effects-of-environmental-enrichment-on-self-administration-of-the-short-acting-opioid-remifentanil-in-male-rats
#16
Rebecca S Hofford, Jonathan J Chow, Joshua S Beckmann, Michael T Bardo
BACKGROUND: Opioid abuse is a major problem around the world. Identifying environmental factors that contribute to opioid abuse and addiction is necessary for decreasing this epidemic. In rodents, environmental enrichment protects against the development of low dose stimulant self-administration, but studies examining the effect of enrichment and isolation (compared to standard housing) on the development of intravenous opioid self-administration have not been conducted. The present study investigated the role of environmental enrichment on self-administration of the short-acting μ-opioid remifentanil...
December 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28903835/soyabean-oil-supplementation-effects-on-perivascular-inflammation-in-lungs-induced-by-bisphenol-a-a-histological-study
#17
Sadia Shaukat, Shabnam Hamid, Faiza Umbreen
OBJECTIVE: To determine the effect of soyabean oil supplementation on perivascular inflammation in lungs of adult mice induced by Bisphenol A(BPA). STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with the Animal House, National Institute of Health, Islamabad, from June to November 2016. METHODOLOGY: Thirty male and female BALB/c mice were divided into three groups, of 10 animals each...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28893674/seroepidemiology-of-leptospirosis-among-febrile-patients-in-a-rapidly-growing-suburban-slum-and-a-flood-vulnerable-rural-district-in-mozambique-2012-2014-implications-for-the-management-of-fever
#18
Policarpo Ribeiro, Nilesh Bhatt, Sádia Ali, Vanessa Monteiro, Edmilson da Silva, Ilana Teruszkin Balassiano, Carolina Aquino, Nilsa de Deus, Onelia Guiliche, Argentina Felisbela Muianga, Pascoal Jorge Alho, Virginia Lara Evaristo, Ivan Manhiça, Marco Medeiros, Eduardo Samo Gudo
OBJECTIVE: Leptospirosis is one of the most widespread zoonoses in the world and is caused by spirochetes of the genus Leptospira. In Mozambique, the disease is largely ignored and its epidemiology is unknown. The objective of this study was to investigate the occurrence of leptospirosis in febrile patients. METHODS: This cross-sectional study was performed between July 2012 and September 2015 among febrile patients. A total of 373 paired serum samples were drawn from febrile patients; 208 were from Caia District Hospital (rural setting) in Sofala Province and 165 were from Polana Caniço General Hospital (suburban setting) in Maputo City...
September 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28877172/automated-recording-of-home-cage-activity-and-temperature-of-individual-rats-housed-in-social-groups-the-rodent-big-brother-project
#19
William S Redfern, Karen Tse, Claire Grant, Amy Keerie, David J Simpson, John C Pedersen, Victoria Rimmer, Lauren Leslie, Stephanie K Klein, Natasha A Karp, Rowland Sillito, Agis Chartsias, Tim Lukins, James Heward, Catherine Vickers, Kathryn Chapman, J Douglas Armstrong
Measuring the activity and temperature of rats is commonly required in biomedical research. Conventional approaches necessitate single housing, which affects their behavior and wellbeing. We have used a subcutaneous radiofrequency identification (RFID) transponder to measure ambulatory activity and temperature of individual rats when group-housed in conventional, rack-mounted home cages. The transponder location and temperature is detected by a matrix of antennae in a baseplate under the cage. An infrared high-definition camera acquires side-view video of the cage and also enables automated detection of vertical activity...
2017: PloS One
https://www.readbyqxmd.com/read/28872575/partner-loss-in-monogamous-rodents-modulation-of-pain-and-emotional-behavior-in-male-prairie-voles
#20
Yoji Osako, Reiko Nobuhara, Young-Chang P Arai, Kenjiro Tanaka, Larry J Young, Makoto Nishihara, Shinichi Mitsui, Kazunari Yuri
OBJECTIVE: Pain is modulated by psychosocial factors and social stress-induced hyperalgesia is a common clinical symptom in pain disorders. To provide a new animal model for studying social modulation of pain, we examined pain behaviors in monogamous prairie voles experiencing partner loss. METHODS: After cohabitation with novel females, males (n=79) were divided into two groups on the basis of preference test scores. Half of the males of each group were separated from their partner (loss group), while the other half remained paired (paired group)...
September 1, 2017: Psychosomatic Medicine
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