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Animal qe

Dongdong Sun, Weiwei Zhang, Nuan Li, Zhiwei Zhao, Zhipeng Mou, Endong Yang, Weiyun Wang
Quercetin (Qe) exhibited extremely low water solubility, and thus, it was modified using silver nanoparticles (AgNPs). We fabricated AgNPs combined with Qe (AgNPs-Qe). The modification suggested that the synergistic properties of Qe enhanced the antibacterial activity of AgNPs. However, AgNPs-Qe exerted no effect on many kinds of drug-resistant bacteria, including Pseudomonas aeruginosa and Bacillus subtilis. RNA interference has considerable therapeutic potential because of its high specificity and potential capability to evade drug resistance...
June 2016: Materials Science & Engineering. C, Materials for Biological Applications
Oluwatosin Adekunle Adaramoye, Olubukola Oyebimpe Akanni
BACKGROUND: Cadmium (Cd) is an environmental risk factor with an established toxicity in animals. Therefore, natural antioxidants may be protective against Cd-toxicity. The study was designed to investigate the modulatory effects of methanol extract of Artocarpus altilis (AA) on oxidant-antioxidant balance and lipid profile in liver and kidney of Cd-exposed rats while quercetin (QE) served as standard. METHODS: Total phenolic content (TPC) and 2,2-diphenyl-1-picryldydrazyl (DPPH) radical scavenging activity of AA were assessed in vitro...
March 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Ting Qi, Yujie Cao, Liyong Cao, Yongming Gao, Shuijin Zhu, Xiangyang Lou, Haiming Xu
The seeds of flowering plants develop from double fertilization and play a vital role in reproduction and supplying human and animal food. The genetic variation of seed traits is influenced by multiple genetic systems, e.g., maternal, embryo, and/or endosperm genomes. Understanding the genetic architecture of seed traits is a major challenge because of this complex mechanism of multiple genetic systems, especially the epistasis within or between different genomes and their interactions with the environment...
January 2015: Genetics
Nikolaos E Ioannidis, Kiriakos Kotzabasis
Non photochemical quenching is a fundamental mechanism in photosynthesis, which protects plants against excess excitation energy and is of crucial importance for their survival and fitness. In the last decades hundreds of papers have appeared that describe the role of antenna regulation in protection or the so called qE response. However, the exact quenching site is still obscure. Previously overlooked features of the antenna may provide hints towards the elucidation of its functionality and of the quenching mechanism...
January 7, 2015: Journal of Theoretical Biology
Jean Paul Dzoyem, Victor Kuete, Lyndy J McGaw, Jacobus N Eloff
ETHNOPHARMACOLOGICAL RELEVANCE: Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their traditional use and safety. In this study, the 15-lipoxygenase inhibitory, antioxidant, antimycobacterial and the cytotoxic activities, total phenolic and flavonoid contents of fourteen edible plants were investigated...
October 28, 2014: Journal of Ethnopharmacology
Aliyu Muhammad, Oyeronke A Odunola, Michael A Gbadegesin, Ayodeji M Adegoke, J Olorunjuwon Olugbami, Ndidi S Uche
Effect of Acacia honey from north-west Nigeria on sodium arsenite-induced oxidative damage and clastogenicity in male Wistar rats was investigated. Animals were divided into four groups and were treated daily via oral gavage for one week before they were sacrificed. Brain, liver and blood serum were collected for antioxidant and protein assays. Clastogenicity, in vitro antioxidant activity, vitamins and minerals were also evaluated. From the results, co-administration of Acacia honey with sodium arsenite on the animals increased (P < 0...
2015: Natural Product Research
Meryem Gencer, Turan Karaca, Ayşe N C Güngör, Servet Ö Hacıvelioğlu, Selim Demirtaş, Hakan Turkon, Ahmet Uysal, Fatma Korkmaz, Emine Coşar, Volkan Hancı
OBJECTIVE: To investigate the protective effect of quercetin (QE), an anti-inflammatory and anti-oxidant agent, on torsion-detorsion induced histopathological changes and blood IMA levels in experimental ovarian ischemia-reperfusion (IR) injury. STUDY DESIGN: Twenty-four female Wistar rats were randomly divided into four groups in this study (n=6). Group I, (sham operation); Group II, torsion-detorsion plus saline (IR); Group III, torsion-detorsion plus solvent (dimethylsulfoxide: DMSO, IR+DMSO); Group IV, torsion-detorsion plus 15 mg/kg/bw quercetin (IR+QE) injected intraperitoneally 30 min prior to detorsion...
June 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Mehmet Kanter, Cuneyt Unsal, Cevat Aktas, Mustafa Erboga
The purpose of the present investigation was to evaluate cadmium (Cd)-induced neurotoxicity in hippocampal tissues and beneficial effect of quercetin (QE) against neuronal damage. A total of 30 male rats were divided into 3 groups: control, Cd-treated, and Cd + QE-treated groups. After the treatment, the animals were killed and hippocampal tissues were removed for biochemical and histopathological investigation. Cd significantly increased tissue malondialdehyde (MDA) and protein carbonyl (PC) levels and also decreased superoxide dismutase (SOD) and catalase (CAT) enzyme activities in hippocampal tissue compared with the control...
March 2016: Toxicology and Industrial Health
R Jeyadevi, T Sivasudha, A Rameshkumar, D Arul Ananth, G Smilin Bell Aseervatham, K Kumaresan, L Dinesh Kumar, S Jagadeeswari, R Renganathan
In this present study, we investigated thio glycolic acid-capped cadmium telluride quantum dots (TGA-CdTe QDs) as nano carrier to study the antiarthritic activity of quercetin on adjuvant induced arthritic Wistar rats. The free radical scavenging activity of QDs-QE complex was evaluated by 2,2'-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and superoxide anion scavenging assays. Fifteen days after adjuvant induction, arthritic rats received QDs-QE complex orally at the dose of 0...
December 1, 2013: Colloids and Surfaces. B, Biointerfaces
Chan-Min Liu, Gui-Hong Zheng, Chao Cheng, Jian-Mei Sun
Quercetin (QE), the major bioflavonoid in the human diet, has been reported to have many benefits and medicinal properties. However, its protective effects against lead (Pb)-induced neurotoxicity have not been clarified. The aim of the present study was to investigate the effects of QE on neurotoxicity in mice exposed to Pb. Mice were exposed to lead acetate (20 mg/kg body weight/day) intragastrically with or without QE (15 and 30 mg/kg body weight/day) coadministration for 3 months. The data showed that QE significantly prevented Pb-induced neurotoxicity in a dose-dependent manner...
August 7, 2013: Journal of Agricultural and Food Chemistry
Cüneyt Unsal, Mehmet Kanter, Cevat Aktas, Mustafa Erboga
The present study was carried out to evaluate the neuroprotective effect of quercetin (QE) in protecting the cadmium (Cd)-induced neuronal injury in frontal cortex of rats. A total of 30 adult male Sprague-Dawley rats were randomly divided into three groups of 10 animals each: control, Cd treated and Cd treated with QE. The Cd-treated group was injected subcutaneously with cadmium chloride (CdCl2) dissolved in saline at a dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in QE-treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection, during the study period...
December 2015: Toxicology and Industrial Health
S Milton Prabu, M Muthumani, K Shagirtha
BACKGROUND: Cadmium is one of the potent cardiotoxic heavy metals in the environment, which induces oxidative stress, dyslipidemia and membrane disturbances in heart. Quercetin is an effective antioxidant and free radical scavenger against oxidative stress. This study was designed to evaluate the protective effect of quercetin (QE) on cardiac marker enzymes, lipid peroxidation products, lipid profile, membrane bound ATPases and antioxidant status in cadmium (Cd)-intoxicated rats. MATERIALS AND METHODS: Twenty four male albino rats were used...
March 2013: European Review for Medical and Pharmacological Sciences
Mir Z Gul, Farhan Ahmad, Anand K Kondapi, Insaf A Qureshi, Irfan A Ghazi
BACKGROUND: The use of traditional medicine at the primary health care level is widespread and plant-based treatments are being recommended for curing various diseases by traditional medical practitioners all over the world. The phytochemicals present in the fruits, vegetables and medicinal plants are getting attention day-by-day for their active role in the prevention of several human diseases. Abrus precatorius is a widely distributed tropical medicinal plant with several therapeutic properties...
2013: BMC Complementary and Alternative Medicine
A Gohlke, C J Ingelmann, G Nürnberg, A Starke, S Wolffram, C C Metges
Because of their health-promoting properties, flavonoids are used in feed supplements for ruminants, although scientific evidence for their efficacy in vivo is limited. It has been shown recently that bioavailability of quercetin is low after ruminal administration in cows because of degradation by the ruminal microbiota. It is unknown whether quercetin could be absorbed from the small intestine in ruminants if degradation is prevented; therefore, we investigated the bioavailability of quercetin after duodenal administration in 6 German Holstein cows...
April 2013: Journal of Dairy Science
Saikat Sen, Raja Chakraborty, B Rekha, D Revathi, S Chinna Ayyanna, G Hemalatha, G Ashok Kumar Reddy, S Hyndavi, P Jeevan Ikhyatha Babu, P Ravi Prakash, C Sridhar
CONTEXT: Pisonia aculeata leaves (Nyctagenaceae), a Folk medicinal plant used in the treatment of several inflammation, pain, and oxidative stress associated diseases. OBJECTIVE: To evaluate anti-inflammatory, analgesic, and antioxidant potential of crude methanol extract of P. aculeata leaves (MEPA). MATERIALS AND METHODS: Analgesic and anti-inflammatory activities of MEPA (250 and 500 mg/kg) were evaluated using writhing, formalin, hot plate, tail flick, carrageenan-induced paw edema test, and membrane stabilizing activity...
April 2013: Pharmaceutical Biology
Hanna Johansson Jänkänpää, Martin Frenkel, Ismayil Zulfugarov, Michael Reichelt, Anja Krieger-Liszkay, Yogesh Mishra, Jonathan Gershenzon, Jon Moen, Choon-Hwan Lee, Stefan Jansson
Under natural conditions, plants have to cope with numerous stresses, including light-stress and herbivory. This raises intriguing questions regarding possible trade-offs between stress defences and growth. As part of a program designed to address these questions we have compared herbivory defences and damage in wild type Arabidopsis thaliana and two "photoprotection genotypes", npq4 and oePsbS, which respectively lack and overexpress PsbS (a protein that plays a key role in qE-type non-photochemical quenching)...
2013: PloS One
Xiaohui Lv, Yongwang Guo, Dazhao Shi
The effects of the two sterilants, quinestrol (QE) and levonorgestrel (LNG) on serum prolactin (PRL) level in lactating Mongolian gerbils and reproductive parameters of their offspring were examined in the study. Both sterilants increased the serum PRL level in lactating gerbils. The body weight as well as weights of the ovary, testis, epididymides, and seminal vesicles were lower, whereas that of the uterus was higher in the pups originating from QE-treated mothers in comparison to controls. Histological ovarian sections of the offspring from QE-treated mothers contained only growing follicles, whereas their uterine sections showed a thinner endometrium, thicker myometrium, and greater epithelial-cell height than in controls...
November 2012: Reproductive Biology
Mohamed Ahmed Abdelmoaty, M A Ibrahim, N S Ahmed, M A Abdelaziz
Quercetin (QE), one of natural flavanoid group, was widely distributed as a secondary metabolite in plant kingdom. It has been believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus (DM). The aim of the present study was the evaluation of possible effects of QE on blood glucose and antioxidant enzymes in experimental streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally with single dose of 50 mg/kg for diabetes induction. QE (15 mg/kg bw day, intraperitoneal (i...
April 2010: Indian Journal of Clinical Biochemistry: IJCB
Nikolaos E Ioannidis, Oriol Lopera, Mireya Santos, Josep M Torné, Kiriakos Kotzabasis
Transglutaminases function as biological glues in animal cells, plant cells and microbes. In energy producing organelles such as chloroplasts the presence of transglutaminases was recently confirmed. Furthermore, a plastidial transglutaminase has been cloned from maize and the first plants overexpressing tgz are available (Nicotiana tabacum TGZ OE). Our hypothesis is that the overexpression of plastidal transglutaminase will alter photosynthesis via increased polyamination of the antenna of photosystem II. We have used standard analytical tools to separate the antenna from photosystem II in wild type and modified plants, 6 specific antibodies against LHCbs to confirm their presence and sensitive HPLC method to quantify the polyamination level of these proteins...
2012: PloS One
Chan-Min Liu, Yun-Zhi Sun, Jian-Mei Sun, Jie-Qiong Ma, Chao Cheng
BACKGROUND: Lead (Pb) exposure is considered as a risk factor for the development of renal dysfunction. The flavonoid quercetin (QE) in diets exerts the nephroprotective effects. This study investigated the effects of quercetin on renal oxidative stress and inflammation in rats exposed to Pb. METHODS: Wistar rats were divided into normal, lead exposure groups, lead plus quercetin groups and quercetin groups. Rats were exposed to lead acetate in the drinking water (500mgPb/L) with or without quercetin co-administration (25 and 50mgQU/kg intragastrically once daily)...
October 2012: Biochimica et Biophysica Acta
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