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https://www.readbyqxmd.com/read/28323960/fgf23-is-not-associated-with-age-related-changes-in-phosphate-but-enhances-renal-calcium-reabsorption-in-girls
#1
Deborah M Mitchell, Harald Jüppner, Sherri-Ann M Burnett-Bowie
Context: Fibroblast growth factor 23 (FGF23) is a critical determinant of phosphate homeostasis. The role of FGF23, however, in regulating physiologic changes in serum phosphate and renal phosphate handling across childhood is not well-described. In addition, animal models have suggested a role for FGF23 in regulating renal calcium excretion. Objective: To assess changes in FGF23 concentrations across childhood in relation to changes in mineral ions and hormones of mineral ion homeostasis...
January 31, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28320043/effects-of-ranolazine-in-a-model-of-doxorubicin-induced-left-ventricle-diastolic-dysfunction
#2
Donato Cappetta, Grazia Esposito, Raffaele Coppini, Elena Piegari, Rosa Russo, Loreta Pia Ciuffreda, Alessia Rivellino, Lorenzo Santini, Concetta Rafaniello, Cristina Scavone, Francesco Rossi, Liberato Berrino, Konrad Urbanek, Antonella De Angelis
BACKGROUND AND PURPOSE: Doxorubicin (DOXO) is a highly effective anticancer drug but its clinical application is impeded by cardiotoxicity. Asymptomatic diastolic dysfunction can be the earliest manifestation of DOXO cardiotoxicity. Therefore, a search for therapeutic intervention that can interfere with early manifestations and possibly prevent late cardiotoxicity is warranted. Increased DOXO-dependent reactive oxygen species may explain, in part, Ca(2+) and Na(+) overload that contributes to diastolic dysfunction and development of heart failure...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28319324/future-of-robotic-surgery-in-urology
#3
Jens J Rassweiler, Riccardo Autorino, Jan Klein, Alex Mottrie, Ali Serdar Goezen, Jens-Uwe Stolzenburg, Koon H Rha, Marc Schurr, Jihad Kaouk, Vipul Patel, Prokar Dasgupta, Evangelos Liatsikos
OBJECTIVES: To provide a comprehensive overview of the current status and future perspectives in the field of robotic systems for urologic surgery. MATERIALS AND METHODS: A non-systematic literature review was performed by using PubMed / Medline search electronic engines. Existing patents for robotic devices were researched using the Google search machine. Findings were critically analyzed also by taking into account personal experience of the authors. RESULTS: Relevant patents of the first generation of the da Vinci platform will expire in 2019...
March 20, 2017: BJU International
https://www.readbyqxmd.com/read/28315653/techniques-for-nonterminal-blood-sampling-in-black-tailed-prairie-dogs-cynomys-ludovicianus
#4
Valerie Head, David Eshar, Melissa R Nau
Black-tailed prairie dogs (Cynomys ludovicianus) are used as an animal model for research on gallbladder stones and several infectious diseases. A comprehensive, instructive resource regarding the appropriate techniques for venipuncture and collection of nonterminal blood samples in this species has not yet been published. Blood samples (1 mL or larger) were readily obtained from the jugular vein, femoral vein, or cranial vena cava, whereas peripheral sites, such as the cephalic vein, saphenous vein, and tarsal vein, mainly were useful for obtaining smaller volumes...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28301310/glass-fiber-based-mr-safe-guidewire-for-mr-imaging-guided-endovascular-interventions-in-vitro-and-preclinical-in-vivo-feasibility-study
#5
Alexander Massmann, Arno Buecker, Guenther K Schneider
Purpose To evaluate glass-fiber-based guidewires that are safe for magnetic resonance (MR) imaging-guided endovascular interventions by using a phantom and an in vivo swine model. Materials and Methods MR imaging-safe guidewires were made from micropultruded glass and/or aramid fibers and epoxy resin with diameters of 0.89 mm (0.035 inch) for standard and stiff guidewires and 0.36 mm (0.014 inch) for micro guidewires. MR imaging visibility and mechanical properties were assessed in a pulsatile flow model. After approval was obtained from the institutional animal care and use committee, MR imaging guidewires were evaluated for standard endovascular procedures in nine pigs...
March 14, 2017: Radiology
https://www.readbyqxmd.com/read/28300643/draft-genome-sequence-of-multidrug-resistant-salmonella-enterica-serovar-brancaster-strain-ps01-isolated-from-chicken-meat-malaysia
#6
Pui San Chin, Choo Yee Yu, Geik Yong Ang, Wai-Fong Yin, Kok-Gan Chan
OBJECTIVES: Salmonella spp. represent one of the main diarrhoeal pathogens that are transmitted via the food supply chain. Here we report the draft genome sequence of a multidrug-resistant Salmonella enterica serovar Brancaster (PS01) that was isolated from poultry meat in Malaysia. METHODS: Genomic DNA was extracted from Salmonella strain PS01 and was sequenced using an Illumina HiSeq 2000 platform. The generated reads were de novo assembled using CLC Genomics Workbench...
March 11, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28299547/managers-of-molecular-imaging-laboratories-momil-interest-group
#7
Michael L Nickels, Mark D Pagel
The Managers of Molecular Imaging Laboratories (MOMIL) interest group in the World Molecular Imaging Society provides a forum for exchanging information between researchers who manage molecular imaging laboratories and institutional core facilities. This information exchange includes operational procedures for acquiring and analyzing imaging results, including considerations for quality assurance and quality control, and animal handling and care for imaging studies. MOMIL also exchanges administrative policies, interactions with collaborators and clients, and industry relations...
March 15, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28299214/occupational-neurobrucellosis-mimicking-a-brain-tumor-a-case-report-and-review-of-the-literature
#8
Hussein Algahtani, Bader Shirah, Dina Abdulghani, Roiya Farhan, Raghad Algahtani
Brucellosis is a zoonotic bacterial infection which is transmitted to humans from infected animals and is endemic in many parts of the world including Saudi Arabia. In this article, we report a case of occupational neurobrucellosis that presented with a space-occupying lesion mimicking a brain tumor. We stress on the importance of obtaining detailed social history including occupation to reach the diagnosis in several conditions including brucellosis. We also stress on taking universal precautions when handling any specimens...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28298228/is-transport-distance-correlated-with-animal-welfare-and-carcass-quality-of-reindeer-rangifer-tarandus-tarandus
#9
Sauli Laaksonen, Pikka Jokelainen, Jyrki Pusenius, Antti Oksanen
BACKGROUND: Slaughter reindeer are exposed to stress caused by gathering, handling, loading and unloading, and by conditions in vehicles during transport. These stress factors can lead to compromised welfare and trauma such as bruises or fractures, aspiration of rumen content, and abnormal odour in carcasses, and causing condemnations in meat inspection and lower meat quality. We investigated the statistical association of slaughter transport distance with these indices using meat inspection data from years 2004-2016, including inspection of 669,738 reindeer originating from Finnish reindeer herding areas...
March 15, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28297585/electromechanical-conditioning-of-adult-progenitor-cells-improves-recovery-of-cardiac-function-after-myocardial-infarction
#10
Aida Llucià-Valldeperas, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Benjamin Sanchez, Ramon Bragos, Gordana Vunjak-Novakovic, Antoni Bayes-Genis
Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. Our goals were (a) to study the viability of a tissue-engineered construct with cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs) and (b) to examine the effect of electromechanically stimulated cardiac ATDPCs within a myocardial infarction (MI) model in mice for the first time...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28287791/adolescent-chronic-restraint-stress-acrs-elicits-robust-depressive-like-behavior-in-freely-cycling-adult-female-rats-without-increasing-anxiety-like-behaviors
#11
Meghan Hibicke, Martha A Graham, Renée L Hayslett
Stress during times of rapid development is a risk factor for Major Depressive Disorder, a mood disorder that disproportionately affects women. We developed an adolescent chronic restraint stress (aCRS) protocol using female rats to address the impact of adolescent stress on female adult depressive-like behavior. Animals were divided into 4 treatment groups: not restrained:saline (NRSAL), not restrained:desipramine (NRDES), restrained:saline (RSAL), and restrained:desipramine (RDES). NRSAL and NRDES rats were housed in a separate colony room from RSAL and RDES rats...
March 13, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28287594/magnetic-stirrer-method-for-the-detection-of-trichinella-larvae-in-muscle-samples
#12
Anne Mayer-Scholl, Edoardo Pozio, Jennifer Gayda, Nora Thaben, Peter Bahn, Karsten Nöckler
Trichinellosis is a debilitating disease in humans and is caused by the consumption of raw or undercooked meat of animals infected with the nematode larvae of the genus Trichinella. The most important sources of human infections worldwide are game meat and pork or pork products. In many countries, the prevention of human trichinellosis is based on the identification of infected animals by means of the artificial digestion of muscle samples from susceptible animal carcasses. There are several methods based on the digestion of meat but the magnetic stirrer method is considered the gold standard...
March 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28287586/introducing-clicker-training-as-a-cognitive-enrichment-for-laboratory-mice
#13
Charlotte Leidinger, Felix Herrmann, Christa Thöne-Reineke, Nadine Baumgart, Jan Baumgart
Establishing new refinement strategies in laboratory animal science is a central goal in fulfilling the requirements of Directive 2010/63/EU. Previous research determined a profound impact of gentle handling protocols on the well-being of laboratory mice. By introducing clicker training to the keeping of mice, not only do we promote the amicable treatment of mice, but we also enable them to experience cognitive enrichment. Clicker training is a form of positive reinforcement training using a conditioned secondary reinforcer, the "click" sound of a clicker, which serves as a time bridge between the strengthened behavior and an upcoming reward...
March 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28279642/low-intensity-400%C3%A2-mw-cm-2-500%C3%A2-khz-pulsed-transcranial-ultrasound-preconditioning-may-mitigate-focal-cerebral-ischemia-in-rats
#14
Hangdao Li, Junfeng Sun, Daqu Zhang, Daryl Omire-Mayor, Peter A Lewin, Shanbao Tong
BACKGROUND: Preconditioning methods, which could increase tolerance of brain to subsequent ischemic injuries with a small dose of non-injury stimuli, have gained attention. Capitalizing on noninvasiveness and safety of ultrasound modality, the pulsed transcranial ultrasound stimulation (pTUS) approach may provide a novel treatment for patients with high risk of stroke. OBJECTIVE: This study's goal was to investigate whether the risk of stroke could be minimized or eliminated by prior exposure to low-intensity, pulsed transcranial ultrasound stimulation (pTUS)...
February 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28273177/acute-exhaustive-aerobic-exercise-training-impair-cardiomyocyte-function-and-calcium-handling-in-sprague-dawley-rats
#15
Kristine Ljones, Henning Ofstad Ness, Karin Solvang-Garten, Svein Erik Gaustad, Morten Andre Høydal
INTRODUCTION: Recent data from long-distance endurance participants suggest that cardiac function is impaired after completion. Existing data further indicate that right ventricular function is more affected than left ventricular function. The cellular mechanisms underpinning cardiac deterioration are limited and therefore the aim of this study was to examine cardiomyocyte and molecular responses of the right and left ventricle to an acute bout of exhaustive endurance exercise. MATERIALS AND METHODS: Male Sprague-Dawley rats were assigned to sedentary controls or acute exhaustive endurance exercise consisting of a 120 minutes long forced treadmill run...
2017: PloS One
https://www.readbyqxmd.com/read/28271855/prevalence-of-foodborne-pathogens-in-food-from-selected-african-countries-a-meta-analysis
#16
REVIEW
Narayan Paudyal, Victor Anihouvi, Joseph Hounhouigan, Maitshwarelo Ignatius Matsheka, Bonno Sekwati-Monang, Wisdom Amoa-Awua, Amy Atter, Nina Bernice Ackah, Samuel Mbugua, Agnes Asagbra, Warda Abdelgadir, Jesca Nakavuma, Mogens Jakobsen, Weihuan Fang
Food safety information in the African region is insufficient and fragmented due to lack of surveillance, documentation and reporting, thereby resulting in inefficient utilization of resources, duplication of activities, and lack of synergy among the countries of the region. This paper reviews the prevalence of foodborne pathogens in seven African countries (Benin, Botswana, Ghana, Kenya, Nigeria, Sudan and Uganda) from papers in regional or international journals published between January 2000 and December 2015...
March 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28271815/wild-game-consumption-habits-among-italian-shooters-relevance-for-intakes-of-cadmium-perfluorooctanesulphonic-acid-and-137-cesium-as-priority-contaminants
#17
Mauro Ferri, Loredana Baldi, Stefania Cavallo, Roberta Pellicanò, Gianfranco Brambilla
The consumption habits of 766 Italian shooters (96% males, 4% females), on average 52 years old, have been investigated, in Italy, through the distribution of questionnaires delivered during shooters' attendance to training and teaching courses, in compliance with 853/2004/EC Regulation provisions on food hygiene. The most consumed wild species recorded were pheasant > woodcock > choke among feathered animals, and wild boar > hare > roe deer among mammals, respectively. An average of 100-200 g game per serving (four servings per month) was consumed, with highest intakes of 3000 g per month; meat, liver, and heart were the preferred food items...
March 8, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28271632/the-role-of-insufficient-copper-in-lipid-synthesis-and-fatty-liver-disease
#18
REVIEW
Austin Morrell, Savannah Tallino, Lei Yu, Jason L Burkhead
The essential transition metal copper is important in lipid metabolism, redox balance, iron mobilization, and many other critical processes in eukaryotic organisms. Genetic diseases where copper homeostasis is disrupted, including Menkes disease and Wilson disease, indicate the importance of copper balance to human health. The severe consequences of insufficient copper supply are illustrated by Menkes disease, caused by mutation in the X-linked ATP7A gene encoding a protein that transports copper from intestinal epithelia into the bloodstream and across the blood-brain barrier...
March 8, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28270538/chemotherapy-drug-handling-in-first-opinion-small-animal-veterinary-practices-in-the-united-kingdom-results-of-a-questionnaire-survey
#19
E G Edery
To investigate how first opinion small animal veterinary surgeons in the UK handled chemotherapeutic agents, a questionnaire was distributed at the 2014 British Small Animal Veterinary Association congress and by internet. Chemotherapy was regularly offered by 70.4 per cent of the respondents. Gold standards defined according to available guidelines for safe handling of antineoplastic drugs were poorly followed by general practitioners with only 2 per cent of respondents complying with all of them. Dedicated facilities for preparation and administration of cytotoxic drugs were variably available among participants...
March 7, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28269560/lab-on-chips-for-manipulation-of-small-scale-organisms-to-facilitate-imaging-of-neurons-and-organs
#20
Ramtin Ardeshiri, Pouya Rezai
Caenorhabditis elegans (C. elegans) and Drosophila melanogaster (D. melanogaster) are widely-used model organisms for neurological and cardiac studies due to their simple neuronal (302 neurons in C. elegans) and cardiac (simple tubular organ in D. melanogaster) systems. However, their small sizes and continuous mobility impede their precise and timely manipulation, hence, limiting the assays that can be done using conventional manual methods. This has resulted in a need for technologies that allow multidirectional manipulation of model organisms to enable studies on target neurons and organs throughout the body...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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